1201:
1184:
620:
597:
1264:
1045:
2621:
31:
5382:
2371:
1299:
after the medicine reached the market. In
September 2010, the FDA reversed its decision to remove midodrine from the market and allowed it to remain available to patients while Shire plc collected further data regarding the efficacy and safety of the drug. Shire announced on September 22, 2011, that
1752:
Chen JJ, Han Y, Tang J, Portillo I, Hauser RA, Dashtipour K (December 2018). "Standing and Supine Blood
Pressure Outcomes Associated With Droxidopa and Midodrine in Patients With Neurogenic Orthostatic Hypotension: A Bayesian Meta-analysis and Mixed Treatment Comparison of Randomized Trials".
915:
but that midodrine but not droxidopa increased the risk of high blood pressure when lying down. Small studies have also shown that midodrine can be used to prevent excessive drops in blood pressure in people requiring
2652:
997:
Headache, feeling of pressure or fullness in the head, vasodilation or flushing face, scalp tingling, confusion or thinking abnormality, dry mouth, nervousness or anxiety, and rash, among others.
935:; the proposed mechanism is constriction of splanchnic vessels and dilation of renal vasculature. Studies have not been sufficiently well conducted to show a clear place for midodrine.
243:
1037:-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure. Desglymidodrine does not stimulate cardiac
1874:
Narasimhan B, Aggarwal D, Satish P, Kantharia B, Aronow WS (October 2022). "Postural orthostatic tachycardia syndrome: pathophysiology, management, and experimental therapies".
2645:
1709:
Izcovich A, González Malla C, Manzotti M, Catalano HN, Guyatt G (September 2014). "Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review".
1061:
After oral administration, midodrine is rapidly absorbed. The plasma levels of the prodrug peak after about half an hour, and decline with a half-life of approximately 25
895:
Midodrine is indicated for the treatment of symptomatic orthostatic hypotension. It can reduce dizziness and faints by about a third, but can be limited by troublesome
3040:
2638:
1796:
Prakash S, Garg AX, Heidenheim AP, House AA (October 2004). "Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review".
2369:, Zoelss G, "Phenylethanolamine derivs prepn. - by reducing azides, useful as hypertensives", issued 21 April 1983, assigned to Lentia GmbH.
198:
2333:
Cao T, Martini ML, Park K, Kaniskan HÜ, Jin J (1 January 2022). "8.02 - Pyrimidines and Their Benzo
Derivatives". In Black DS, Cossy J, Stevens CV (eds.).
3117:
2416:
2390:
3982:
3962:
2136:
McClellan KJ, Wiseman LR, Wilde MI (January 1998). "Midodrine. A review of its therapeutic use in the management of orthostatic hypotension".
1065:
minutes, while the metabolite reaches peak blood concentrations about 1 to 2 hours after a dose of midodrine and has a half-life of about 3 to
5407:
69:
2490:
3033:
715:
4690:
4017:
3270:
943:
5348:
3026:
2472:
2171:
1510:
5330:
5321:
2034:
5427:
5312:
2984:
2594:
2560:
2519:
2350:
2281:
1686:
1619:
2101:
Cruz DN (May 2000). "Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension".
689:
2430:
5339:
1831:
Karwa R, Woodis CB (April 2009). "Midodrine and octreotide in treatment of cirrhosis-related hemodynamic complications".
1343:
2274:
Rote Liste 2017 – Arzneimittelverzeichnis für
Deutschland (einschließlich EU-Zulassungen und bestimmter Medizinprodukte)
1325:
760:
735:
120:
3001:
5412:
366:
228:
101:
5357:
1560:
445:
4348:
1352:
1911:"Choices and Challenges With Drug Therapy in Postural Orthostatic Tachycardia Syndrome: A Systematic Review"
615:
5437:
5303:
1277:
496:
565:
5417:
4182:
3732:
3472:
3060:
2901:
2797:
2630:
1085:
1023:
865:
576:
176:
743:
InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)
5422:
5372:
3637:
2625:
1376:
1296:
1116:
2412:
2366:
2295:
344:
5452:
5447:
2586:
Drugs
Available Abroad: A Guide to Therapeutic Drugs Available and Approved for Use Outside the U. S.
2386:
3655:
1439:
1096:
592:
4303:
2449:
Food and Drug
Administration. FDA proposes withdrawal of low blood pressure drug . August 16, 2010
1038:
977:
Midodrine is contraindicated in patients with severe organic heart disease, acute kidney disease,
2989:
1285:
1081:
793:
157:
43:
1909:
Vasavada AM, Verma D, Sheggari V, Ghetiya S, Chirumamilla PC, Kotak RA, et al. (May 2023).
5432:
4068:
3760:
3750:
3321:
3078:
2776:
1394:
1125:
Midodrine is an odorless, white, crystalline powder, soluble in water and sparingly soluble in
1089:
908:
79:
2550:
2509:
1676:
989:. Midodrine should not be used in patients with persistent and excessive supine hypertension.
4267:
4043:
3686:
1385:
1334:
1245:
1229:
1133:
786:
700:
545:
436:
187:
2555:. Index Nominum: International Drug Directory. Medpharm Scientific Publishers. p. 805.
4926:
2296:"Acetylation of dimethoxybenzenes with acetic anhydride in the presence of acidic zeolites"
1225:
932:
797:
505:
400:
321:
485:
8:
5402:
4605:
4471:
3947:
3853:
3250:
3156:
3049:
1300:
it was withdrawing completely from supplying midodrine. Midodrine remains available as a
1119:
963:
955:
858:
801:
391:
164:
2078:
2053:
1937:
1910:
619:
596:
3052:
2960:
2689:
2342:
1986:
1961:
1856:
1778:
1734:
1611:
1240:
by any set of standard schemes, and the ketone reduced to an alcohol with borohydride (
1136:
is -0.5 and its predicted log P ranges from -0.49 to -0.95. The predicted log P of its
131:
2311:
5442:
5036:
5011:
4931:
3809:
3559:
3424:
2661:
2590:
2556:
2515:
2469:
2346:
2315:
2277:
2153:
2149:
2118:
2083:
1991:
1942:
1891:
1860:
1848:
1813:
1770:
1726:
1682:
1615:
1291:
In August 2010, the FDA proposed withdrawing this approval because the manufacturer,
1200:
1183:
1137:
1100:
1015:
978:
966:
904:
903:, gastrointestinal discomfort, chills, elevated blood pressure while lying down, and
847:
839:
835:
256:
93:
1782:
1678:
The
Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies
5006:
4570:
4413:
4212:
3790:
3552:
3542:
3103:
2950:
2811:
2338:
2307:
2145:
2110:
2073:
2065:
1981:
1973:
1932:
1922:
1883:
1840:
1805:
1762:
1738:
1718:
1638:
1607:
1368:
982:
873:
632:
266:
211:
2223:
1887:
5386:
3804:
3112:
3018:
2584:
2476:
2248:
2198:
1977:
1722:
1140:
1074:
1070:
1049:
1019:
917:
850:
831:
705:
425:
311:
304:
288:
280:
274:
2665:
907:. A meta-analysis of clinical trials of midodrine or droxidopa in patients with
4916:
4585:
4550:
4271:
4027:
3937:
3690:
3555:
3275:
3230:
2995:
2905:
986:
877:
2397:
1276:
Midodrine was discovered by 1971. It was approved in the United States by the
5396:
5066:
4906:
4590:
4534:
4491:
4152:
4076:
3942:
3881:
3770:
3659:
3571:
3325:
3245:
3240:
3184:
3171:
2887:
2882:
2729:
2444:
2319:
2114:
1766:
1365:
939:
884:
608:
1962:"Postural tachycardia syndrome: a heterogeneous and multifactorial disorder"
5091:
5076:
5021:
4516:
4338:
4283:
4275:
4247:
4207:
4126:
4092:
3907:
3702:
3694:
3675:
3663:
3547:
3416:
3392:
3352:
2955:
2755:
2719:
2679:
2122:
2087:
2009:
1995:
1946:
1895:
1852:
1817:
1774:
1730:
1321:
1301:
1281:
883:
Midodrine was discovered by 1971 and was introduced for medical use in the
811:
206:
2660:
2157:
2052:
Costa-Pinto R, Jones DA, Udy AA, Warrillow SJ, Bellomo R (December 2022).
22:
5216:
5191:
5186:
5181:
5071:
5046:
5031:
5016:
4981:
4966:
4946:
4941:
4911:
4891:
4866:
4851:
4796:
4741:
4670:
4665:
4660:
4620:
4615:
4521:
4506:
4476:
4466:
4451:
4422:
4393:
4237:
4227:
4202:
4192:
4157:
4100:
4063:
3992:
3987:
3967:
3932:
3868:
3843:
3833:
3814:
3775:
3645:
3522:
3517:
3477:
3452:
3442:
3432:
3402:
3397:
3372:
3347:
3341:
3306:
3265:
3260:
3225:
3210:
3205:
3151:
3141:
3122:
3083:
2934:
2919:
2872:
2786:
2760:
2709:
2704:
2674:
1927:
1809:
896:
815:
807:
782:
191:
87:
1484:
465:
5281:
5271:
5261:
5246:
5241:
5226:
5206:
5201:
5176:
5171:
5156:
5136:
5131:
5126:
5096:
5086:
5081:
5051:
5041:
5001:
4991:
4971:
4921:
4901:
4881:
4876:
4856:
4841:
4836:
4826:
4806:
4801:
4791:
4786:
4781:
4761:
4746:
4736:
4716:
4695:
4680:
4655:
4650:
4645:
4630:
4625:
4610:
4595:
4580:
4575:
4565:
4555:
4511:
4496:
4486:
4461:
4456:
4437:
4427:
4408:
4403:
4383:
4378:
4368:
4363:
4353:
4343:
4333:
4323:
4318:
4262:
4252:
4242:
4232:
4172:
4162:
4142:
4137:
4122:
4096:
4088:
4084:
4058:
4053:
4002:
3997:
3977:
3972:
3927:
3917:
3912:
3902:
3863:
3848:
3838:
3799:
3785:
3681:
3671:
3632:
3627:
3617:
3612:
3602:
3587:
3563:
3537:
3527:
3512:
3507:
3497:
3492:
3462:
3447:
3420:
3382:
3368:
3364:
3360:
3337:
3333:
3296:
3255:
3235:
3215:
3200:
3166:
3146:
3098:
3093:
2965:
2851:
2841:
2819:
2792:
2750:
2745:
2724:
1152:
928:
854:
823:
789:
665:
476:
298:
171:
2069:
1844:
1708:
1263:
5276:
5266:
5251:
5231:
5221:
5196:
5166:
5146:
5141:
5121:
5116:
5111:
5061:
5056:
5026:
4996:
4986:
4951:
4936:
4896:
4886:
4871:
4861:
4846:
4821:
4816:
4811:
4776:
4771:
4751:
4721:
4685:
4640:
4635:
4600:
4560:
4501:
4481:
4442:
4388:
4373:
4358:
4328:
4289:
4257:
4222:
4217:
4187:
4132:
4114:
4110:
4080:
4072:
4012:
3952:
3922:
3897:
3858:
3824:
3780:
3718:
3649:
3641:
3622:
3607:
3597:
3592:
3577:
3567:
3532:
3502:
3487:
3482:
3467:
3457:
3436:
3407:
3387:
3376:
3329:
3316:
3311:
3301:
3291:
3161:
3132:
3088:
2970:
2929:
2924:
2877:
2867:
2846:
2781:
2511:
Concise
Dictionary of Pharmacological Agents: Properties and Synonyms
1292:
1252:. The halogen is then displaced with azide and the resulting product
924:
912:
411:
73:
5161:
5151:
5101:
4976:
4961:
4956:
4766:
4731:
4726:
4700:
4675:
4542:
4432:
4398:
4279:
4177:
4167:
4147:
4118:
4104:
4048:
4022:
4007:
3889:
3819:
3708:
3698:
3582:
3428:
3412:
3356:
3192:
3127:
2914:
2835:
2470:
Midodrine (ProAmatine, generic) Proposed Market
Withdrawal – Update
2176:
1442:, but no recent development for this indication has been reported.
1156:
1126:
900:
819:
525:
456:
115:
1044:
688:
5256:
5236:
5211:
5106:
4831:
4756:
4197:
3765:
3713:
3667:
1873:
1030:
1011:
911:
found that midodrine increased standing blood pressure more than
861:
843:
183:
2548:
2010:"Midodrine - FDA prescribing information, side effects and uses"
4526:
3873:
3755:
3176:
2620:
1244:). Acylation of the amino group in this last intermediate with
827:
556:
2054:"Midodrine use in critically ill patients: a narrative review"
679:
536:
2051:
1908:
1867:
581:
30:
3957:
2276:. Rote Liste Service GmbH, Frankfurt/Main, 2017, Aufl. 57,
516:
64:-acetamide; 1-2',5'-Dimethoxyphenyl-1)-2 glycinamidoethanol
2172:"DailyMed - MIDODRINE HCL- midodrine hydrochloride tablet"
1795:
1602:
2129:
1902:
1402:. The drug is also known by its developmental code names
1326:
2241:
1080:
Midodrine and desglymidodrine diffuse poorly across the
2216:
2045:
2491:"Shire Provides Update on ProAmatine® (midodrine HCl)"
2332:
1410:. Midodrine has been sold under brand names including
1344:
1151:
Midodrine contains a stereocenter and consists of two
5370:
2135:
1438:
Midodrine was under development for the treatment of
1353:
1256:
reduced catalytically to the glycinamide, midodrine (
1485:"Midodrine: Uses, Interactions, Mechanism of Action"
2544:
2542:
2540:
2538:
2035:"Midodrine (Oral Route) Side Effects - Mayo Clinic"
1751:
444:
3048:
2431:U.S. proposes withdrawal of Shire hypotension drug
2293:
1555:
1553:
1551:
1377:
1549:
1547:
1545:
1543:
1541:
1539:
1537:
1535:
1533:
1531:
1111:Midodrine, also known as 3,6-dimethoxy-β-hydroxy-
5394:
2535:
923:Midodrine has been used in the complications of
424:
1561:"ProAmatine® (midodrine hydrochloride) Tablets"
942:to increase blood pressure in the treatment of
399:
2501:
2294:Moreau P, Finiels A, Meric P (20 March 2000).
1528:
1395:
3034:
2646:
2576:
1953:
1633:
1631:
1386:
1335:
1236:. The halogen is then converted to the amine
1597:
1595:
1593:
1591:
1589:
1587:
1585:
1511:"Proamatine- midodrine hydrochloride tablet"
119:
60:-aminoethanonyl-2-phenylethylamine; 2-Amino-
48:Amatine, Gutron, Orvaten, ProAmatine, others
2552:Index Nominum: International Drug Directory
1830:
1479:
1477:
1475:
1088:and are not associated with effects in the
3041:
3027:
2653:
2639:
2507:
2300:Journal of Molecular Catalysis A: Chemical
2266:
1670:
1668:
1666:
1664:
1662:
1660:
1628:
1473:
1471:
1469:
1467:
1465:
1463:
1461:
1459:
1457:
1455:
1095:Neither midodrine nor desglymidodrine are
1033:and exerts its actions via activation of α
618:
595:
484:
2582:
2549:Schweizerischer Apotheker-Verein (2004).
2442:
2077:
1985:
1959:
1936:
1926:
1582:
1331:Tooltip International Nonproprietary Name
1115:-aminoethanonyl-2-phenylethylamine, is a
944:postural orthostatic tachycardia syndrome
504:
56:ST-1085; TS-701; 3,6-Dimethoxy-β-hydroxy-
2445:"FDA recommends withdrawal of midodrine"
2365:
2094:
1262:
1043:
2335:Comprehensive Heterocyclic Chemistry IV
2191:
1657:
1452:
796:(low blood pressure when standing) and
591:
464:
92:
5395:
1604:Primer on the Autonomic Nervous System
1601:
1349:Tooltip Dénomination Commune Française
1307:
1005:
609:
3022:
2634:
2514:. Springer Netherlands. p. 137.
2488:
2337:. Oxford: Elsevier. pp. 86–228.
1798:Nephrology, Dialysis, Transplantation
1358:Tooltip Denominazione Comune Italiana
564:
544:
250:
110:
78:
5408:Alpha-1 adrenergic receptor agonists
2401:(1965, 1967 both to Chemie Linz Ag).
2100:
1674:
972:
616:100.151.349 100.050.842, 100.151.349
210:
1280:(FDA) in 1996 for the treatment of
1056:
524:
415:
13:
2589:Gale Research. pp. 139, 356.
2343:10.1016/B978-0-12-818655-8.00041-X
1382:Tooltip United States Adopted Name
1146:
949:
14:
5464:
2614:
2272:Rote Liste Service GmbH (Hrsg.):
237:
142:
16:Vasopressor/antihypotensive agent
5380:
2619:
2150:10.2165/00002512-199812010-00007
1612:10.1016/b978-012589762-4/50113-4
1267:Synthesis of midodrine See also:
1199:
1182:
909:low blood pressure when standing
649:
643:
29:
5349:Monoamine metabolism modulators
2482:
2463:
2436:
2424:
2410:Zoelss & W. Karl-Anton Ing
2404:
2378:
2359:
2326:
2287:
2164:
2027:
2002:
1824:
1000:
992:
890:
748:Key:PTKSEFOSCHHMPD-UHFFFAOYSA-N
2664:excluding cardiac glycosides (
1960:Benarroch EE (December 2012).
1789:
1745:
1702:
1606:. Elsevier. pp. 413–415.
1570:. Food and Drug Administration
1503:
1400:Tooltip Japanese Accepted Name
954:Midodrine is available in the
655:
637:
1:
5331:Monoamine reuptake inhibitors
5304:Receptor/signaling modulators
2312:10.1016/S1381-1169(99)00373-8
1888:10.1080/13543784.2022.2121697
1833:The Annals of Pharmacotherapy
1755:The Annals of Pharmacotherapy
1445:
1391:Tooltip British Approved Name
1340:Tooltip British Approved Name
773:, sold under the brand names
5428:Peripherally selective drugs
2902:Phosphodiesterase inhibitors
2249:"Metabolite desglymidodrine"
1978:10.1016/j.mayocp.2012.08.013
1723:10.1212/WNL.0000000000000815
1681:. Springer US. p. 824.
1278:Food and Drug Administration
1219:
1106:
7:
4414:Deoxyepinephrine (epinine,
3791:Deoxyepinephrine (epinine,
3638:Tetracyclic antidepressants
3104:Deoxyepinephrine (epinine,
2508:Morton IK, Hall JM (2012).
1433:
1143:ranges from -0.01 to 0.15.
723:O=C(NCC(O)c1cc(OC)ccc1OC)CN
10:
5469:
5340:Monoamine releasing agents
1876:Expert Opin Investig Drugs
1271:
1117:substituted phenethylamine
1073:of midodrine (measured as
872:. This in turn results in
627:Chemical and physical data
5294:
4709:
4311:
4302:
4036:
3743:
3731:
3656:Tricyclic antidepressants
3284:
3071:
3059:
2979:
2943:
2900:
2860:
2828:
2810:
2769:
2738:
2697:
2688:
2673:
1177:Enantiomers of midodrine
1176:
1132:Midodrine's experimental
756:
731:
711:
699:
677:
664:
631:
626:
607:
575:
555:
535:
515:
495:
475:
455:
435:
410:
390:
362:
357:
343:
320:
310:
297:
287:
273:
265:
227:
222:
197:
170:
156:
130:
100:
86:
68:
52:
42:
37:
28:
2944:Other cardiac stimulants
2115:10.1517/14656566.1.4.835
2103:Expert Opin Pharmacother
1767:10.1177/1060028018786954
1440:chronic fatigue syndrome
1312:
4069:Atypical antipsychotics
3322:Atypical antipsychotics
1373:midodrine hydrochloride
1286:orthostatic hypotension
1232:gives the chloroketone
1212:CAS number: 133267-39-7
1195:CAS number: 133163-25-4
927:. It is also used with
814:(high blood pressure),
794:orthostatic hypotension
5413:Antihypotensive agents
4268:Typical antipsychotics
3751:(R)-3-Nitrobiphenyline
3687:Typical antipsychotics
2777:Amezinium metilsulfate
2421:(1974 to Lentia GmbH).
1371:, its generic name is
1268:
1090:central nervous system
1086:peripherally selective
1069:4 hours. The absolute
1053:
1048:Chemical structure of
1039:β-adrenergic receptors
5358:Monoamine neurotoxins
2628:at Wikimedia Commons
2583:Schlesser JL (1990).
2475:28 March 2012 at the
2398:U.S. patent 3,340,298
1364:. In the case of the
1295:, failed to complete
1266:
1246:chloroacetyl chloride
1230:chloroacetyl chloride
1047:
810:of midodrine include
188:Antihypotensive agent
4927:Dichloroisoprenaline
1928:10.7759/cureus.38887
1324:of the drug and its
1226:1,4-dimethoxybenzene
1163:, a 1:1 mixture of (
1028:-adrenergic receptor
933:hepatorenal syndrome
870:-adrenergic receptor
798:urinary incontinence
335:Desglymidodrine: 2–4
181:-Adrenergic receptor
5438:Phenylethanolamines
4606:Phenylpropanolamine
4472:Ethylnorepinephrine
3948:Phenylpropanolamine
3854:Ethylnorepinephrine
3251:Phenylpropanolamine
3157:Ethylnorepinephrine
3050:Adrenergic receptor
2690:Adrenergic agonists
2384:K. Wismayr et al.,
1308:Society and culture
1082:blood–brain barrier
1006:Mechanism of action
781:among others, is a
246:(Prescription only)
25:
5418:Cardiac stimulants
3006:Never to phase III
2961:Omecamtiv mecarbil
2662:Cardiac stimulants
2495:www.prnewswire.com
2479:10 September 2010.
2039:www.mayoclinic.org
1810:10.1093/ndt/gfh420
1491:. 31 December 1992
1269:
1248:affords the amide
1084:and are therefore
1054:
938:Midodrine is used
345:Duration of action
21:
5423:CYP2D6 inhibitors
5368:
5367:
5361:
5352:
5343:
5334:
5325:
5316:
5307:
5290:
5289:
5037:Iodocyanopindolol
5012:Hydroxytertatolol
4932:Dihydroalprenolol
4545:
4537:
4529:
4446:
4298:
4297:
3892:
3884:
3876:
3828:
3810:Dihydroergotamine
3727:
3726:
3560:hydroxynefazodone
3425:dihydroergotamine
3195:
3187:
3179:
3136:
3016:
3015:
2896:
2895:
2861:Unknown/ungrouped
2812:Dopamine agonists
2806:
2805:
2624:Media related to
2596:978-0-8103-7177-4
2562:978-3-88763-101-7
2521:978-94-011-4439-1
2433:, 16 August 2010.
2352:978-0-12-818656-5
2282:978-3-946057-10-9
2224:"Desglymidodrine"
2070:10.51893/2022.4.R
1972:(12): 1214–1225.
1882:(10): 1017–1025.
1845:10.1345/aph.1L373
1804:(10): 2553–2558.
1761:(12): 1182–1194.
1717:(13): 1170–1177.
1688:978-1-4757-2085-3
1645:. 21 October 2021
1621:978-0-12-589762-4
1217:
1216:
1213:
1196:
1138:active metabolite
1101:monoamine oxidase
1016:active metabolite
979:urinary retention
973:Contraindications
958:of 2.5, 5, and 10
905:urinary retention
848:active metabolite
842:. Midodrine is a
840:urinary frequency
836:urinary retention
768:
767:
690:Interactive image
577:CompTox Dashboard
254:
241:
146:
113:
5460:
5453:Vasoconstrictors
5448:Sympathomimetics
5385:
5384:
5383:
5376:
5355:
5346:
5337:
5328:
5319:
5310:
5298:
5007:Hydroxycarteolol
4571:Methoxyphenamine
4543:
4535:
4530:-DOPA (levodopa)
4527:
4444:
4418:-methyldopamine)
4309:
4308:
4213:Phenoxybenzamine
3890:
3882:
3877:-DOPA (levodopa)
3874:
3826:
3795:-methyldopamine)
3741:
3740:
3553:Phenylpiperazine
3543:Phenoxybenzamine
3193:
3185:
3180:-DOPA (levodopa)
3177:
3134:
3118:Dexisometheptene
3108:-methyldopamine)
3069:
3068:
3043:
3036:
3029:
3020:
3019:
2951:Angiotensinamide
2695:
2694:
2686:
2685:
2655:
2648:
2641:
2632:
2631:
2623:
2608:
2607:
2605:
2603:
2580:
2574:
2573:
2571:
2569:
2546:
2533:
2532:
2530:
2528:
2505:
2499:
2498:
2497:(Press release).
2486:
2480:
2467:
2461:
2460:
2458:
2456:
2440:
2434:
2428:
2422:
2420:
2419:
2415:
2408:
2402:
2400:
2394:
2393:
2389:
2382:
2376:
2375:
2374:
2370:
2363:
2357:
2356:
2330:
2324:
2323:
2291:
2285:
2270:
2264:
2263:
2261:
2259:
2245:
2239:
2238:
2236:
2234:
2220:
2214:
2213:
2211:
2209:
2195:
2189:
2188:
2186:
2184:
2168:
2162:
2161:
2133:
2127:
2126:
2098:
2092:
2091:
2081:
2058:Crit Care Resusc
2049:
2043:
2042:
2031:
2025:
2024:
2022:
2020:
2006:
2000:
1999:
1989:
1957:
1951:
1950:
1940:
1930:
1906:
1900:
1899:
1871:
1865:
1864:
1828:
1822:
1821:
1793:
1787:
1786:
1749:
1743:
1742:
1706:
1700:
1699:
1697:
1695:
1672:
1655:
1654:
1652:
1650:
1635:
1626:
1625:
1599:
1580:
1579:
1577:
1575:
1565:
1557:
1526:
1525:
1523:
1521:
1507:
1501:
1500:
1498:
1496:
1481:
1430:, among others.
1401:
1397:
1392:
1388:
1383:
1379:
1375:and this is its
1359:
1355:
1350:
1346:
1341:
1337:
1332:
1328:
1297:required studies
1211:
1203:
1194:
1186:
1174:
1173:
1068:
1064:
1057:Pharmacokinetics
1014:which forms the
983:pheochromocytoma
961:
874:vasoconstriction
764:
763:
692:
672:
657:
651:
645:
639:
622:
611:
600:
599:
585:
583:
568:
548:
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468:
448:
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403:
352:
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332:
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252:
249:
239:
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214:
144:
141:
123:
112:
109:
96:
82:
33:
26:
24:
20:
5468:
5467:
5463:
5462:
5461:
5459:
5458:
5457:
5393:
5392:
5391:
5381:
5379:
5371:
5369:
5364:
5286:
4705:
4294:
4032:
3805:Dexmedetomidine
3736:
3723:
3556:antidepressants
3280:
3113:Desglymidodrine
3064:
3055:
3047:
3017:
3012:
3011:
2996:Clinical trials
2975:
2939:
2892:
2856:
2824:
2802:
2765:
2734:
2678:
2669:
2659:
2617:
2612:
2611:
2601:
2599:
2597:
2581:
2577:
2567:
2565:
2563:
2547:
2536:
2526:
2524:
2522:
2506:
2502:
2487:
2483:
2477:Wayback Machine
2468:
2464:
2454:
2452:
2441:
2437:
2429:
2425:
2417:
2411:
2409:
2405:
2396:
2391:
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2383:
2379:
2372:
2364:
2360:
2353:
2331:
2327:
2292:
2288:
2271:
2267:
2257:
2255:
2253:DrugBank Online
2247:
2246:
2242:
2232:
2230:
2222:
2221:
2217:
2207:
2205:
2197:
2196:
2192:
2182:
2180:
2170:
2169:
2165:
2134:
2130:
2099:
2095:
2050:
2046:
2033:
2032:
2028:
2018:
2016:
2008:
2007:
2003:
1958:
1954:
1907:
1903:
1872:
1868:
1829:
1825:
1794:
1790:
1750:
1746:
1707:
1703:
1693:
1691:
1689:
1675:Elks J (2014).
1673:
1658:
1648:
1646:
1639:"GE Healthcare"
1637:
1636:
1629:
1622:
1600:
1583:
1573:
1571:
1563:
1559:
1558:
1529:
1519:
1517:
1509:
1508:
1504:
1494:
1492:
1489:DrugBank Online
1483:
1482:
1453:
1448:
1436:
1399:
1390:
1381:
1357:
1348:
1339:
1330:
1315:
1310:
1274:
1222:
1210:
1204:
1193:
1187:
1149:
1147:Stereochemistry
1141:desglymidodrine
1109:
1075:desglymidodrine
1071:bioavailability
1066:
1062:
1059:
1050:desglymidodrine
1036:
1027:
1020:desglymidodrine
1010:Midodrine is a
1008:
1003:
995:
975:
959:
952:
950:Available forms
893:
869:
851:desglymidodrine
832:urinary urgency
787:antihypotensive
759:
757:
752:
749:
744:
739:
738:
727:
724:
719:
718:
706:Racemic mixture
695:
670:
660:
654:
648:
642:
603:
579:
571:
551:
531:
511:
491:
471:
451:
431:
414:
406:
386:
383:
370:
369:
350:
336:
334:
330:
323:
312:Onset of action
305:Desglymidodrine
281:desglymidodrine
275:Bioavailability
267:Pharmacokinetic
261:
218:
180:
159:
152:
133:
126:
17:
12:
11:
5:
5466:
5456:
5455:
5450:
5445:
5440:
5435:
5430:
5425:
5420:
5415:
5410:
5405:
5390:
5389:
5366:
5365:
5363:
5362:
5353:
5344:
5335:
5326:
5317:
5308:
5295:
5292:
5291:
5288:
5287:
5285:
5284:
5279:
5274:
5269:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5229:
5224:
5219:
5214:
5209:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5154:
5149:
5144:
5139:
5134:
5129:
5124:
5119:
5114:
5109:
5104:
5099:
5094:
5089:
5084:
5079:
5074:
5069:
5064:
5059:
5054:
5049:
5044:
5039:
5034:
5029:
5024:
5019:
5014:
5009:
5004:
4999:
4994:
4989:
4984:
4979:
4974:
4969:
4964:
4959:
4954:
4949:
4944:
4939:
4934:
4929:
4924:
4919:
4917:Dexpropranolol
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4879:
4874:
4869:
4864:
4859:
4854:
4849:
4844:
4839:
4834:
4829:
4824:
4819:
4814:
4809:
4804:
4799:
4794:
4789:
4784:
4779:
4774:
4769:
4764:
4759:
4754:
4749:
4744:
4739:
4734:
4729:
4724:
4719:
4713:
4711:
4707:
4706:
4704:
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4668:
4663:
4658:
4653:
4648:
4643:
4638:
4633:
4628:
4623:
4618:
4613:
4608:
4603:
4598:
4593:
4588:
4586:Norepinephrine
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4551:Levosalbutamol
4548:
4540:
4538:-Phenylalanine
4532:
4524:
4519:
4514:
4509:
4504:
4499:
4494:
4489:
4484:
4479:
4474:
4469:
4464:
4459:
4454:
4449:
4440:
4435:
4430:
4425:
4420:
4411:
4406:
4401:
4396:
4391:
4386:
4381:
4376:
4371:
4366:
4361:
4356:
4351:
4346:
4341:
4336:
4331:
4326:
4321:
4315:
4313:
4306:
4300:
4299:
4296:
4295:
4293:
4292:
4287:
4272:chlorpromazine
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4135:
4130:
4108:
4066:
4061:
4056:
4051:
4046:
4040:
4038:
4034:
4033:
4031:
4030:
4028:Xylometazoline
4025:
4020:
4015:
4010:
4005:
4000:
3995:
3990:
3985:
3980:
3975:
3970:
3965:
3960:
3955:
3950:
3945:
3940:
3938:Norepinephrine
3935:
3930:
3925:
3920:
3915:
3910:
3905:
3900:
3895:
3887:
3885:-Phenylalanine
3879:
3871:
3866:
3861:
3856:
3851:
3846:
3841:
3836:
3831:
3822:
3817:
3812:
3807:
3802:
3797:
3788:
3783:
3778:
3773:
3768:
3763:
3758:
3753:
3747:
3745:
3738:
3734:
3729:
3728:
3725:
3724:
3722:
3721:
3716:
3711:
3706:
3691:chlorpromazine
3684:
3679:
3653:
3635:
3630:
3625:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3585:
3580:
3575:
3550:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3445:
3440:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3350:
3345:
3319:
3314:
3309:
3304:
3299:
3294:
3288:
3286:
3282:
3281:
3279:
3278:
3276:Xylometazoline
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3233:
3231:Norepinephrine
3228:
3223:
3218:
3213:
3208:
3203:
3198:
3190:
3188:-Phenylalanine
3182:
3174:
3169:
3164:
3159:
3154:
3149:
3144:
3139:
3130:
3125:
3120:
3115:
3110:
3101:
3096:
3091:
3086:
3081:
3075:
3073:
3066:
3062:
3057:
3056:
3046:
3045:
3038:
3031:
3023:
3014:
3013:
3010:
3009:
3008:
3007:
3004:
2993:
2987:
2981:
2980:
2977:
2976:
2974:
2973:
2968:
2963:
2958:
2953:
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2945:
2941:
2940:
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2927:
2922:
2917:
2911:
2909:
2898:
2897:
2894:
2893:
2891:
2890:
2885:
2880:
2875:
2870:
2864:
2862:
2858:
2857:
2855:
2854:
2849:
2844:
2839:
2832:
2830:
2826:
2825:
2823:
2822:
2816:
2814:
2808:
2807:
2804:
2803:
2801:
2800:
2798:Norepinephrine
2795:
2790:
2784:
2779:
2773:
2771:
2767:
2766:
2764:
2763:
2758:
2753:
2748:
2742:
2740:
2736:
2735:
2733:
2732:
2727:
2722:
2717:
2712:
2707:
2701:
2699:
2692:
2683:
2671:
2670:
2658:
2657:
2650:
2643:
2635:
2616:
2615:External links
2613:
2610:
2609:
2595:
2575:
2561:
2534:
2520:
2500:
2481:
2462:
2451:. TheHeart.org
2435:
2423:
2403:
2377:
2358:
2351:
2325:
2306:(1): 185–192.
2286:
2265:
2240:
2215:
2190:
2163:
2128:
2109:(4): 835–840.
2093:
2064:(4): 298–308.
2044:
2026:
2001:
1966:Mayo Clin Proc
1952:
1901:
1866:
1839:(4): 692–699.
1823:
1788:
1744:
1701:
1687:
1656:
1627:
1620:
1581:
1527:
1502:
1450:
1449:
1447:
1444:
1435:
1432:
1314:
1311:
1309:
1306:
1273:
1270:
1221:
1218:
1215:
1214:
1197:
1179:
1178:
1155:, making it a
1148:
1145:
1108:
1105:
1058:
1055:
1034:
1025:
1022:, which is an
1007:
1004:
1002:
999:
994:
991:
987:thyrotoxicosis
974:
971:
951:
948:
892:
889:
878:blood pressure
876:and increased
867:
800:. It is taken
792:used to treat
766:
765:
754:
753:
751:
750:
747:
745:
742:
734:
733:
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541:
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387:
385:
384:
373:
365:
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359:
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354:
347:
341:
340:
329:Midodrine: 0.5
327:
318:
317:
314:
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301:
295:
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219:
217:
216:
203:
201:
195:
194:
178:
174:
168:
167:
162:
160:administration
154:
153:
151:
150:
148:
138:
136:
128:
127:
125:
124:
106:
104:
98:
97:
90:
84:
83:
76:
66:
65:
54:
50:
49:
46:
40:
39:
35:
34:
15:
9:
6:
4:
3:
2:
5465:
5454:
5451:
5449:
5446:
5444:
5441:
5439:
5436:
5434:
5433:Phenol ethers
5431:
5429:
5426:
5424:
5421:
5419:
5416:
5414:
5411:
5409:
5406:
5404:
5401:
5400:
5398:
5388:
5378:
5377:
5374:
5360:
5359:
5354:
5351:
5350:
5345:
5342:
5341:
5336:
5333:
5332:
5327:
5324:
5323:
5322:Serotonergics
5318:
5315:
5314:
5313:Dopaminergics
5309:
5306:
5305:
5302:
5297:
5296:
5293:
5283:
5280:
5278:
5275:
5273:
5270:
5268:
5265:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5148:
5145:
5143:
5140:
5138:
5135:
5133:
5130:
5128:
5125:
5123:
5120:
5118:
5115:
5113:
5110:
5108:
5105:
5103:
5100:
5098:
5095:
5093:
5090:
5088:
5085:
5083:
5080:
5078:
5075:
5073:
5070:
5068:
5067:Levobetaxolol
5065:
5063:
5060:
5058:
5055:
5053:
5050:
5048:
5045:
5043:
5040:
5038:
5035:
5033:
5030:
5028:
5025:
5023:
5020:
5018:
5015:
5013:
5010:
5008:
5005:
5003:
5000:
4998:
4995:
4993:
4990:
4988:
4985:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4953:
4950:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4928:
4925:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4907:Cyanopindolol
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4873:
4870:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4815:
4813:
4810:
4808:
4805:
4803:
4800:
4798:
4795:
4793:
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4748:
4745:
4743:
4740:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4720:
4718:
4715:
4714:
4712:
4708:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4591:Orciprenaline
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4541:
4539:
4533:
4531:
4525:
4523:
4520:
4518:
4515:
4513:
4510:
4508:
4505:
4503:
4500:
4498:
4495:
4493:
4492:Hexoprenaline
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4473:
4470:
4468:
4465:
4463:
4460:
4458:
4455:
4453:
4450:
4448:
4441:
4439:
4436:
4434:
4431:
4429:
4426:
4424:
4421:
4419:
4417:
4412:
4410:
4407:
4405:
4402:
4400:
4397:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4320:
4317:
4316:
4314:
4310:
4307:
4305:
4301:
4291:
4288:
4285:
4281:
4277:
4273:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4153:Esmirtazapine
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4128:
4124:
4120:
4116:
4112:
4109:
4106:
4102:
4098:
4094:
4090:
4086:
4082:
4078:
4077:brexpiprazole
4074:
4070:
4067:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4041:
4039:
4035:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3994:
3991:
3989:
3986:
3984:
3981:
3979:
3976:
3974:
3971:
3969:
3966:
3964:
3961:
3959:
3956:
3954:
3951:
3949:
3946:
3944:
3943:Oxymetazoline
3941:
3939:
3936:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3888:
3886:
3880:
3878:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3830:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3794:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3772:
3771:Apraclonidine
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3752:
3749:
3748:
3746:
3742:
3739:
3737:
3730:
3720:
3717:
3715:
3712:
3710:
3707:
3704:
3700:
3696:
3692:
3688:
3685:
3683:
3680:
3677:
3673:
3669:
3665:
3661:
3660:amitriptyline
3657:
3654:
3651:
3647:
3643:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3584:
3581:
3579:
3576:
3573:
3572:triazoledione
3569:
3565:
3561:
3557:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3438:
3434:
3430:
3426:
3422:
3418:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3378:
3374:
3370:
3366:
3362:
3358:
3354:
3353:Beta blockers
3351:
3349:
3346:
3343:
3339:
3335:
3331:
3327:
3326:brexpiprazole
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3290:
3289:
3287:
3283:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3246:Phenylephrine
3244:
3242:
3241:Oxymetazoline
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3191:
3189:
3183:
3181:
3175:
3173:
3172:Isometheptene
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3140:
3138:
3131:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3107:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3077:
3076:
3074:
3070:
3067:
3065:
3058:
3054:
3051:
3044:
3039:
3037:
3032:
3030:
3025:
3024:
3021:
3005:
3003:
3000:
2999:
2997:
2994:
2991:
2988:
2986:
2983:
2982:
2978:
2972:
2969:
2967:
2964:
2962:
2959:
2957:
2954:
2952:
2949:
2948:
2946:
2942:
2936:
2933:
2931:
2928:
2926:
2923:
2921:
2918:
2916:
2913:
2912:
2910:
2907:
2903:
2899:
2889:
2888:Theodrenaline
2886:
2884:
2883:Mephentermine
2881:
2879:
2876:
2874:
2871:
2869:
2866:
2865:
2863:
2859:
2853:
2850:
2848:
2845:
2843:
2840:
2837:
2834:
2833:
2831:
2827:
2821:
2818:
2817:
2815:
2813:
2809:
2799:
2796:
2794:
2791:
2788:
2785:
2783:
2780:
2778:
2775:
2774:
2772:
2768:
2762:
2759:
2757:
2754:
2752:
2749:
2747:
2744:
2743:
2741:
2737:
2731:
2730:Phenylephrine
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2703:
2702:
2700:
2696:
2693:
2691:
2687:
2684:
2681:
2676:
2672:
2667:
2663:
2656:
2651:
2649:
2644:
2642:
2637:
2636:
2633:
2629:
2627:
2622:
2598:
2592:
2588:
2587:
2579:
2564:
2558:
2554:
2553:
2545:
2543:
2541:
2539:
2523:
2517:
2513:
2512:
2504:
2496:
2492:
2485:
2478:
2474:
2471:
2466:
2450:
2446:
2443:O'Riordan M.
2439:
2432:
2427:
2414:
2407:
2399:
2388:
2381:
2368:
2362:
2354:
2348:
2344:
2340:
2336:
2329:
2321:
2317:
2313:
2309:
2305:
2301:
2297:
2290:
2283:
2279:
2275:
2269:
2254:
2250:
2244:
2229:
2225:
2219:
2204:
2200:
2194:
2179:
2178:
2173:
2167:
2159:
2155:
2151:
2147:
2143:
2139:
2132:
2124:
2120:
2116:
2112:
2108:
2104:
2097:
2089:
2085:
2080:
2075:
2071:
2067:
2063:
2059:
2055:
2048:
2040:
2036:
2030:
2015:
2011:
2005:
1997:
1993:
1988:
1983:
1979:
1975:
1971:
1967:
1963:
1956:
1948:
1944:
1939:
1934:
1929:
1924:
1921:(5): e38887.
1920:
1916:
1912:
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1893:
1889:
1885:
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1877:
1870:
1862:
1858:
1854:
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1834:
1827:
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1784:
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1776:
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1760:
1756:
1748:
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1728:
1724:
1720:
1716:
1712:
1705:
1690:
1684:
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1663:
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1644:
1640:
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1609:
1605:
1598:
1596:
1594:
1592:
1590:
1588:
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1569:
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1486:
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1462:
1460:
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1429:
1425:
1421:
1417:
1413:
1409:
1405:
1398:
1389:
1380:
1374:
1370:
1367:
1366:hydrochloride
1363:
1356:
1347:
1338:
1329:
1323:
1319:
1305:
1303:
1298:
1294:
1289:
1287:
1283:
1279:
1265:
1261:
1259:
1255:
1251:
1247:
1243:
1239:
1235:
1231:
1227:
1224:Acylation of
1208:
1202:
1198:
1191:
1185:
1181:
1180:
1175:
1172:
1170:
1166:
1162:
1158:
1154:
1144:
1142:
1139:
1135:
1130:
1128:
1123:
1121:
1118:
1114:
1104:
1102:
1098:
1093:
1091:
1087:
1083:
1078:
1076:
1072:
1051:
1046:
1042:
1040:
1032:
1029:
1021:
1017:
1013:
998:
990:
988:
984:
980:
970:
968:
965:
957:
947:
945:
941:
936:
934:
930:
926:
921:
919:
914:
910:
906:
902:
898:
888:
886:
885:United States
881:
879:
875:
871:
863:
860:
856:
852:
849:
845:
841:
837:
833:
829:
825:
821:
817:
813:
809:
805:
803:
799:
795:
791:
788:
784:
780:
776:
772:
762:
755:
746:
741:
740:
737:
730:
721:
720:
717:
710:
707:
704:
702:
698:
691:
687:
686:
684:
681:
676:
669:
667:
663:
636:
634:
630:
625:
621:
617:
614:
612:
610:ECHA InfoCard
606:
598:
594:
593:DTXSID0023321
590:
589:
587:
578:
574:
567:
566:ChEMBL1201212
563:
562:
560:
558:
554:
547:
543:
542:
540:
538:
534:
527:
523:
522:
520:
518:
514:
507:
503:
502:
500:
498:
494:
487:
483:
482:
480:
478:
474:
467:
463:
462:
460:
458:
454:
447:
443:
442:
440:
438:
434:
427:
423:
422:
420:
413:
409:
402:
398:
397:
395:
393:
389:
381:
377:
372:
371:
368:
361:
356:
348:
346:
342:
328:
326:
319:
315:
313:
309:
306:
302:
300:
296:
293:Deglycination
292:
290:
286:
282:
278:
276:
272:
268:
264:
258:
248:
245:
235:
234:
232:
230:
226:
221:
213:
208:
205:
204:
202:
200:
196:
193:
189:
185:
182:
175:
173:
169:
166:
163:
161:
155:
149:
140:
139:
137:
135:
129:
122:
117:
108:
107:
105:
103:
99:
95:
91:
89:
85:
81:
77:
75:
71:
67:
63:
59:
55:
51:
47:
45:
41:
38:Clinical data
36:
32:
27:
19:
5356:
5347:
5338:
5329:
5320:
5311:
5300:
5299:
5092:Metipranolol
5077:Levomoprolol
5022:Idropranolol
4517:Isoprenaline
4415:
4339:Arformoterol
4284:thioridazine
4276:fluphenazine
4248:Spiroxatrine
4208:Phentolamine
4127:tandospirone
4093:paliperidone
3983:Tasipimidine
3963:Rezatomidine
3908:Medetomidine
3792:
3703:thioridazine
3695:fluphenazine
3676:trimipramine
3664:clomipramine
3548:Phentolamine
3417:acetergamine
3393:Corynanthine
3220:
3105:
2956:Levosimendan
2756:Isoprenaline
2720:Norfenefrine
2714:
2680:dopaminergic
2618:
2600:. Retrieved
2585:
2578:
2566:. Retrieved
2551:
2525:. Retrieved
2510:
2503:
2494:
2484:
2465:
2453:. Retrieved
2448:
2438:
2426:
2406:
2380:
2361:
2334:
2328:
2303:
2299:
2289:
2273:
2268:
2256:. Retrieved
2252:
2243:
2231:. Retrieved
2227:
2218:
2206:. Retrieved
2202:
2193:
2181:. Retrieved
2175:
2166:
2144:(1): 76–86.
2141:
2137:
2131:
2106:
2102:
2096:
2061:
2057:
2047:
2038:
2029:
2017:. Retrieved
2013:
2004:
1969:
1965:
1955:
1918:
1914:
1904:
1879:
1875:
1869:
1836:
1832:
1826:
1801:
1797:
1791:
1758:
1754:
1747:
1714:
1710:
1704:
1692:. Retrieved
1677:
1647:. Retrieved
1642:
1603:
1572:. Retrieved
1567:
1518:. Retrieved
1514:
1505:
1493:. Retrieved
1488:
1437:
1427:
1423:
1419:
1415:
1411:
1407:
1403:
1372:
1361:
1351:, while its
1322:generic name
1317:
1316:
1302:generic drug
1290:
1282:dysautonomia
1275:
1257:
1253:
1249:
1241:
1237:
1233:
1223:
1206:
1189:
1168:
1164:
1160:
1150:
1131:
1124:
1112:
1110:
1094:
1079:
1060:
1009:
1001:Pharmacology
996:
993:Side effects
976:
953:
937:
922:
894:
891:Medical uses
882:
812:hypertension
808:Side effects
806:
778:
774:
770:
769:
758:
382:-glycinamide
379:
375:
322:Elimination
229:Legal status
223:Legal status
102:License data
61:
57:
18:
5217:Spirendolol
5192:Propranolol
5187:Propafenone
5182:Pronethalol
5072:Levobunolol
5047:Isoxaprolol
5032:Indopanolol
5017:ICI-118,551
4982:Eugenodilol
4967:Ersentilide
4947:Draquinolol
4942:Diprafenone
4912:Dalbraminol
4892:Cicloprolol
4867:Carpindolol
4852:Butofilolol
4797:Bornaprolol
4742:Alprenoxime
4710:Antagonists
4671:Tulobuterol
4666:Tretoquinol
4661:Terbutaline
4621:Ractopamine
4616:Prenalterol
4522:Isoxsuprine
4507:Indacaterol
4477:Eugenodilol
4467:Etilevodopa
4452:Epinephrine
4443:Droxidopa (
4423:Dipivefrine
4394:Clenbuterol
4238:Setiptiline
4228:Rauwolscine
4203:Pardoprunox
4193:Mirtazapine
4158:Fenmetozole
4101:risperidone
4064:Atipamezole
4037:Antagonists
3993:Tiamenidine
3988:Tetryzoline
3968:Rilmenidine
3933:Naphazoline
3869:Guanoxabenz
3844:Epinephrine
3834:Etilevodopa
3825:Droxidopa (
3815:Dipivefrine
3776:Brimonidine
3646:maprotiline
3523:Pardoprunox
3518:Niguldipine
3478:Mepiprazole
3453:Hydroxyzine
3443:Etoperidone
3433:nicergoline
3403:Domesticine
3398:Dapiprazole
3373:eugenodilol
3348:Benoxathian
3342:risperidone
3307:Anisodamine
3285:Antagonists
3266:Tiamenidine
3261:Tetryzoline
3226:Naphazoline
3211:Methoxamine
3206:Metaraminol
3152:Etilevodopa
3142:Epinephrine
3133:Droxidopa (
3123:Dipivefrine
3084:Amidephrine
2992:from market
2935:Vesnarinone
2920:Bucladesine
2873:Dimetofrine
2787:Epinephrine
2761:Prenalterol
2710:Methoxamine
2705:Metaraminol
2489:Shire plc.
2199:"Midodrine"
2138:Drugs Aging
1643:AdisInsight
1209:)-midodrine
1192:)-midodrine
1153:enantiomers
897:goose bumps
816:paresthesia
783:vasopressor
673: g·mol
358:Identifiers
299:Metabolites
192:Vasopressor
88:MedlinePlus
53:Other names
44:Trade names
5403:Acetamides
5397:Categories
5282:Xipranolol
5272:Toliprolol
5262:Tiprenolol
5247:Tienoxolol
5242:Tertatolol
5227:Sulfinalol
5207:Soquinolol
5202:Ronactolol
5177:Procinolol
5172:Primidolol
5157:Penbutolol
5137:Pacrinolol
5132:Oxprenolol
5127:Nipradilol
5097:Metoprolol
5087:Mepindolol
5082:Medroxalol
5052:Isamoltane
5042:Iprocrolol
5002:Flusoxolol
4992:Falintolol
4972:Esatenolol
4922:Diacetolol
4902:Cloranolol
4882:Celiprolol
4877:Carvedilol
4857:Capsinolol
4842:Butaxamine
4837:Bupranolol
4827:Bunitrolol
4807:Bucindolol
4802:Brefonalol
4792:Bopindolol
4787:Bisoprolol
4782:Bevantolol
4762:Arotinolol
4747:Amosulalol
4737:Alprenolol
4717:Acebutolol
4696:Zilpaterol
4681:Vilanterol
4656:Solabegron
4651:Salmeterol
4646:Salbutamol
4631:Reproterol
4626:Procaterol
4611:Pirbuterol
4596:Oxyfedrine
4581:Mirabegron
4576:Methyldopa
4566:Melevodopa
4556:Lubabegron
4512:Isoetarine
4497:Higenamine
4487:Formoterol
4462:Etilefrine
4457:Etafedrine
4438:Dopexamine
4428:Dobutamine
4409:Denopamine
4404:Corbadrine
4384:Carmoterol
4379:Carbuterol
4369:Broxaterol
4364:Bitolterol
4354:Bambuterol
4344:Arotinolol
4334:Arbutamine
4324:Alifedrine
4319:Abediterol
4263:Tolazoline
4253:Sunepitron
4243:Spegatrine
4233:Rotigotine
4173:Ketanserin
4163:Fluparoxan
4143:Cirazoline
4138:Buflomedil
4123:ipsapirone
4111:Azapirones
4097:quetiapine
4089:olanzapine
4085:lurasidone
4059:Aptazapine
4054:Amesergide
4003:Tolonidine
3998:Tizanidine
3978:Talipexole
3973:Romifidine
3928:Moxonidine
3918:Methyldopa
3913:Melevodopa
3903:Lofexidine
3864:Guanfacine
3849:Etilefrine
3839:Ergotamine
3800:Detomidine
3786:Corbadrine
3682:Trimazosin
3672:imipramine
3633:Tolazoline
3628:Tiodazosin
3618:Tamsulosin
3613:Talipexole
3603:Spegatrine
3588:Quinazosin
3564:nefazodone
3538:Phendioxan
3528:Pelanserin
3513:Niaprazine
3508:Neldazosin
3498:Naftopidil
3493:Moxisylyte
3463:Ketanserin
3448:Fenspiride
3421:ergotamine
3383:Buflomedil
3369:carvedilol
3365:arotinolol
3361:amosulalol
3338:quetiapine
3334:olanzapine
3297:Ajmalicine
3256:Synephrine
3236:Octopamine
3216:Methyldopa
3201:Melevodopa
3167:Indanidine
3147:Etilefrine
3099:Corbadrine
3094:Cirazoline
3053:modulators
2966:Pimobendan
2852:Octopamine
2842:Dopexamine
2820:Fenoldopam
2793:Etilefrine
2751:Dobutamine
2746:Arbutamine
2675:Adrenergic
2413:DE 2523735
2367:DE 2506110
1446:References
1428:ProAmatine
1120:derivative
1097:substrates
1077:) is 93%.
929:octreotide
857:acts as a
855:metabolite
824:goosebumps
790:medication
775:ProAmatine
678:3D model (
666:Molar mass
546:CHEBI:6933
506:6YE7PBM15H
477:ChemSpider
437:IUPHAR/BPS
401:42794-76-3
392:CAS Number
367:IUPAC name
289:Metabolism
172:Drug class
5301:See also:
5277:Xibenolol
5267:Tolamolol
5252:Tilisolol
5232:Talinolol
5222:SR 59230A
5197:Ridazolol
5167:Practolol
5147:Pamatolol
5142:Pafenolol
5122:Nifenalol
5117:Nebivolol
5112:Nadoxolol
5062:Landiolol
5057:Labetalol
5027:Indenolol
4997:Flestolol
4987:Exaprolol
4952:Ecastolol
4937:Dilevalol
4897:Cinamolol
4887:Cetamolol
4872:Carteolol
4862:Carazolol
4847:Butidrine
4822:Bufuralol
4817:Bufetolol
4812:Bucumolol
4777:Betaxolol
4772:Befunolol
4752:Ancarolol
4722:Adaprolol
4686:Xamoterol
4641:Ritodrine
4636:Rimiterol
4601:PF-610355
4561:Mabuterol
4546:-Tyrosine
4502:Ibopamine
4482:Fenoterol
4389:Cimaterol
4374:Buphenine
4359:Befunolol
4329:Amibegron
4290:Yohimbine
4258:Terguride
4223:Piribedil
4218:Piperoxan
4188:Mianserin
4133:BRL-44408
4115:buspirone
4081:clozapine
4073:asenapine
4013:Vatinoxan
3953:Piperoxan
3923:Mivazerol
3898:Ibopamine
3893:-Tyrosine
3859:Guanabenz
3781:Clonidine
3719:Zolertine
3650:mianserin
3642:amoxapine
3623:Terazosin
3608:Spiperone
3598:Silodosin
3593:Quinidine
3578:Piperoxan
3568:trazodone
3533:Perlapine
3503:Nantenine
3488:Monatepil
3483:Metazosin
3468:L-765,314
3458:Indoramin
3437:terguride
3413:Ergolines
3408:Doxazosin
3388:Bunazosin
3377:labetalol
3330:clozapine
3317:Atiprosin
3312:Anisodine
3302:Alfuzosin
3292:Abanoquil
3221:Midodrine
3196:-Tyrosine
3162:Ibopamine
3089:Buspirone
3002:Phase III
2990:Withdrawn
2971:Xamoterol
2930:Milrinone
2925:Enoximone
2878:Gepefrine
2868:Cafedrine
2847:Ibopamine
2782:Droxidopa
2715:Midodrine
2626:Midodrine
2602:30 August
2568:30 August
2527:30 August
2395:; eidem,
2387:AT 241435
2320:1381-1169
2284:, S. 196.
2183:5 January
2014:Drugs.com
1861:207263346
1711:Neurology
1694:30 August
1649:28 August
1574:28 August
1520:14 August
1362:midodrina
1318:Midodrine
1293:Shire plc
1220:Synthesis
1171:)-forms:
1107:Chemistry
940:off-label
925:cirrhosis
913:droxidopa
901:skin itch
887:in 1996.
859:selective
771:Midodrine
701:Chirality
324:half-life
158:Routes of
132:Pregnancy
121:Midodrine
80:Monograph
74:Drugs.com
23:Midodrine
5443:Prodrugs
5387:Medicine
5162:Pindolol
5152:Pargolol
5102:Moprolol
4977:Esprolol
4962:Ericolol
4957:Epanolol
4767:Atenolol
4732:Afurolol
4727:Adimolol
4701:Zinterol
4676:Vibegron
4433:Dopamine
4399:Colterol
4312:Agonists
4280:loxapine
4178:Lisuride
4168:Idazoxan
4148:Efaroxan
4119:gepirone
4105:zotepine
4049:Adimolol
4023:Xylazine
4008:Urapidil
3820:Dopamine
3744:Agonists
3709:Urapidil
3699:loxapine
3583:Prazosin
3429:lisuride
3357:adimolol
3128:Dopamine
3072:Agonists
2915:Amrinone
2836:Dopamine
2725:Oxedrine
2473:Archived
2258:1 August
2233:1 August
2208:1 August
2177:DailyMed
2123:11249519
2088:38047013
2079:10692611
1996:23122672
1947:37313107
1938:10259876
1896:36094001
1853:19299324
1818:15280522
1783:49674644
1775:29972032
1731:25150287
1515:DailyMed
1495:1 August
1434:Research
1420:Midamine
1167:)- and (
1157:racemate
1127:methanol
946:(POTS).
918:dialysis
802:by mouth
761:(verify)
457:DrugBank
279:93% (as
199:ATC code
165:By mouth
134:category
116:DailyMed
5257:Timolol
5237:Tazolol
5212:Sotalol
5107:Nadolol
4832:Bunolol
4757:Arnolol
4691:XP21279
4270:(e.g.,
4198:NAN-190
4113:(e.g.,
4071:(e.g.,
4018:XP21279
3766:Amitraz
3714:WB-4101
3689:(e.g.,
3668:doxepin
3658:(e.g.,
3640:(e.g.,
3558:(e.g.,
3415:(e.g.,
3355:(e.g.,
3324:(e.g.,
3271:XP21279
2455:1 April
2228:PubChem
2203:PubChem
2158:9467688
2019:30 June
1987:3547546
1739:5439767
1568:fda.gov
1412:Amatine
1404:ST-1085
1320:is the
1272:History
1031:agonist
1012:prodrug
967:tablets
864:of the
862:agonist
853:. This
846:of its
844:prodrug
820:itching
779:Orvaten
671:254.286
633:Formula
466:DB00211
412:PubChem
316:≤1 hour
215:)
209: (
207:C01CA17
184:agonist
147: C
118::
94:a616030
5373:Portal
4447:-DOPS)
3829:-DOPS)
3756:4-NEMD
3137:-DOPS)
2985:WHO-EM
2682:agents
2593:
2559:
2518:
2418:
2392:
2373:
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2318:
2280:
2156:
2121:
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1915:Cureus
1894:
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1426:, and
1416:Gutron
1408:TS-701
1393:, and
1342:, and
1067:
1063:
960:
838:, and
828:chills
716:SMILES
557:ChEMBL
526:D08220
351:
337:
331:
257:℞-only
255:
242:
114:
3761:6-FNE
3079:6-FNE
2906:PDE3I
2770:mixed
1857:S2CID
1779:S2CID
1735:S2CID
1564:(PDF)
1424:Midon
1313:Names
1228:with
1134:log P
736:InChI
680:JSmol
537:ChEBI
353:hours
339:hours
333:hours
4349:BAAM
4183:mCPP
4044:1-PP
3958:PS75
3473:mCPP
2829:Both
2666:C01C
2604:2024
2591:ISBN
2570:2024
2557:ISBN
2529:2024
2516:ISBN
2457:2011
2347:ISBN
2316:ISSN
2278:ISBN
2260:2024
2235:2024
2210:2024
2185:2023
2154:PMID
2119:PMID
2084:PMID
2021:2022
1992:PMID
1943:PMID
1892:PMID
1849:PMID
1814:PMID
1771:PMID
1727:PMID
1696:2024
1683:ISBN
1651:2024
1616:ISBN
1576:2024
1522:2021
1497:2024
1406:and
1387:BANM
1378:USAN
1369:salt
1354:DCIT
1284:and
1161:i.e.
964:oral
956:form
931:for
777:and
517:KEGG
497:UNII
486:4050
446:7240
426:4195
269:data
70:AHFS
2677:and
2339:doi
2308:doi
2304:154
2146:doi
2111:doi
2074:PMC
2066:doi
1982:PMC
1974:doi
1933:PMC
1923:doi
1884:doi
1841:doi
1806:doi
1763:doi
1719:doi
1608:doi
1396:JAN
1360:is
1345:DCF
1336:BAN
1327:INN
1260:).
1099:of
985:or
962:mg
785:or
582:EPA
416:CID
349:2–6
212:WHO
5399::
4282:,
4278:,
4274:,
4125:,
4121:,
4117:,
4103:,
4099:,
4095:,
4091:,
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2082:.
2072:.
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2060:.
2056:.
2037:.
2012:.
1990:.
1980:.
1970:87
1968:.
1964:.
1941:.
1931:.
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1917:.
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1800:.
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647:18
641:12
378:)-
376:RS
303:•
251:US
244:S4
238:AU
190:;
186:;
143:AU
111:US
5375::
4544:L
4536:L
4528:L
4445:L
4416:N
4304:β
4286:)
4129:)
4107:)
3891:L
3883:L
3875:L
3827:L
3793:N
3735:2
3733:α
3705:)
3678:)
3652:)
3574:)
3439:)
3379:)
3344:)
3194:L
3186:L
3178:L
3135:L
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
