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Sympathomimetic drug

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A primary or secondary aliphatic amine separated by 2 carbons from a substituted benzene ring is minimally required for high agonist activity. The pKa of the amine is approximately 8.5-10. The presence of hydroxy group in the benzene ring at 3rd and 4th position shows maximum alpha- and
398:. The symptoms of physical withdrawal from stimulants can include fatigue, dysphoric mood, increased appetite, vivid or lucid dreams, hypersomnia or insomnia, increased movement or decreased movement, anxiety, and drug craving, as is apparent in the rebound withdrawal from certain 405:
Sympathomimetic drugs are sometimes involved in development of cerebral vasculitis and generalized polyarteritis nodosa like diseases involving immune-complex deposition. Known reports of such hypersensitivity reactions include the use of
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is tertiary, it will have poor direct action. Also, if the amine has bulky substituents, then it will have greater beta adrenergic receptor activity, but if the substituent is not bulky, then it will favor the alpha adrenergic receptors.
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If a drug causes effects similar to the activation of the sympathetic nervous system, it is called a sympathomimetic A sympathomimetic agent increases heart rate, force of cardiac contraction and blood
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Norepinephrine is synthesized by the body from the amino acid tyrosine, and is used in the synthesis of epinephrine, which is a stimulating neurotransmitter of the
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work by causing the release of dopamine and norepinephrine, along with (in some cases) blocking the reuptake of these neurotransmitters.
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The structure can be modified to alter binding. If the amine is primary or secondary, it will have direct action, but if the
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Hydroxyl groups in the meta and para position of the aromatic ring to form a catechol which is essential for receptor binding
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The mechanisms of sympathomimetic drugs can be direct-acting (direct interaction between drug and receptor), such as
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Forman, Howard P.; Levin, Stanley; Stewart, Barbara; Patel, Mahendra; Feinstein, Stuart (1989-05-01).
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of certain neurotransmitters, or stimulating production and release of catecholamines.
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chart). In addition to intended therapeutic use, many of these stimulants have
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These drugs can act through several mechanisms, such as directly activating
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A hydroxyl group at the chiral beta position in the R-configuration
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Herlihy's the Human Body in Health and Illness 1st Anz Edition
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and other drugs at prescribed doses as well as at over-doses.
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For maximum sympathomimetic activity, a drug must have:
751: 394:, although not by the same mechanism(s) as opioids or 101:) are stimulant compounds which mimic the effects of 680:
Medicinal Chemistry of Adrenergics and Cholinergics
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Amine group two carbons away from an aromatic group
209: 1748:1-Methylamino-1-(3,4-methylenedioxyphenyl)propane 4260: 2778:1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine 713:Patestas, Maria A.; Gartner, Leslie P. (2006). 712: 245: 27:Substance that mimics effects of catecholamines 4126: 3710: 858: 697: 702:(7th ed.). Pearson - Benjamin Cummings. 647:. Elsevier Health Sciences. pp. 234–. 640: 4133: 4119: 3717: 3703: 865: 851: 698:Campbell, Neil A.; Reece, Jane B. (2005). 152:. Sympathomimetic drugs are used to treat 835:at the U.S. National Library of Medicine 634: 287: 181: 14: 4261: 790: 729:"Pseudoephedrine Disease Interactions" 4114: 3698: 846: 260:can produce sympathomimetic effects. 256:Direct stimulation of the α- and β- 24: 4228:Hydroxyamphetamine (norpholedrine) 598:(Sudafed, SudoGest, also found in 339: 313: 25: 4280: 826: 797:American Journal of Roentgenology 442:) while sympathomimetics do not. 302:by dopaminergic agonists such as 1743:1-(4-Methylphenyl)-2-aminobutane 434:, but parasympatholytics reduce 324:Dopaminergic stimulants such as 240: 74: 58: 42: 3843:acetylcholinesterase inhibitors 2662:2-Phenyl-3,6-dimethylmorpholine 2356:N,alpha-Diethylphenylethylamine 641:Ellie Kirov (9 November 2021). 306:is used intravenously to treat 264:is a widely used direct-acting 210:Structure-activity relationship 3257:Troparil (β-CPT, WIN 35,065-2) 1858:2-Amino-1,2-dihydronaphthalene 872: 784: 745: 721: 706: 691: 673: 13: 1: 3895:Carbonic anhydrase inhibitors 791:Imbesi, S G (December 1999). 628: 421: 246:Adrenergic receptor agonists 122:force of cardiac contraction 7: 3366:3,3-Diphenylcyclobutanamine 2906:2-Diphenylmethylpyrrolidine 2793:3,4-Dichloromethylphenidate 2788:2-Methyl-3-phenylpiperidine 606: 445: 33:Chemical structures of the 10: 4285: 2361:N,N-Dimethylphenethylamine 809:10.2214/ajr.173.6.10584789 715:A Textbook of Neuroanatomy 618:Sympathetic nervous system 547:methylenedioxypyrovalerone 317: 291: 249: 215:beta-adrenergic activity. 144:), which function as both 110:sympathetic nervous system 4213: 4161: 4067: 4000: 3952: 3893: 3841: 3817: 3794: 3785: 3742: 3679: 3353: 3280: 3082: 3074:Phenylpiracetam hydrazide 3054: 2896: 2768: 2680: 2597: 1733: 1680: 1637: 1579: 1406: 1238: 1205: 1137: 1054: 991: 933:8-Cyclopentyltheophylline 918: 880: 320:Monoamine releasing agent 272:. Other examples include 174:, blocking breakdown and 1398:Phthalimidopropiophenone 837:Medical Subject Headings 400:substituted amphetamines 4002:Prostaglandin analogues 2808:4-Methylmethylphenidate 2803:4-Fluoromethylphenidate 1912:β-Phenylmethamphetamine 1868:5-(2-Aminopropyl)indole 1803:4-Fluoromethamphetamine 1758:2-Fluoromethamphetamine 1363:Methylenedioxycathinone 833:Amines,+Sympathomimetic 717:. Blackwell Publishing. 114:sympathomimetic effects 3132:Dichloropane (RTI-111) 1937:3-Benzhydrylmorpholine 1907:β-Methylphenethylamine 1783:3-Fluoroethamphetamine 1768:2-Phenyl-3-aminobutane 538:(Meth, Crank, Desoxyn) 372:central nervous system 164:, among other things. 3247:Salicylmethylecgonine 2883:Serdexmethylphenidate 2607:3-Fluorophenmetrazine 2306:Dextromethamphetamine 2252:MDMA (midomafetamine) 1838:a-Ethylphenethylamine 1248:3-Fluoromethcathinone 920:Adenosine antagonists 770:10.1542/peds.83.5.737 288:Dopaminergic agonists 196:dopaminergic agonists 192:β-adrenergic agonists 188:α-adrenergic agonists 116:include increases in 91:Sympathomimetic drugs 4039:Latanoprostene bunod 3954:Beta blocking agents 3787:Parasympathomimetics 3581:Naphthylaminopropane 3092:4-fluorotropacocaine 2178:5-Iodo-2-aminoindane 2173:4-Hydroxyamphetamine 2010:Dimethoxyamphetamine 1788:3-Methoxyamphetamine 1139:Arylcyclohexylamines 938:8-Phenyltheophylline 928:8-Chlorotheophylline 258:adrenergic receptors 182:Mechanisms of action 2667:Pseudophenmetrazine 2479:Phenylpropanolamine 2399:-Norpseudoephedrine 2366:Naphthylamphetamine 2310:Levomethamphetamine 2237:MDA (tenamfetamine) 2079:Ethylnorepinephrine 2015:Dimethylamphetamine 1798:4-Fluoroamphetamine 1793:3-Methylamphetamine 1778:3-Fluoroamphetamine 1753:2-Fluoroamphetamine 1026:Levopropylhexedrine 412:phenylpropanolamine 392:physical dependence 308:hypertensive crisis 298:Stimulation of the 2857:Dexmethylphenidate 2843:Isopropylphenidate 2798:4-Benzylpiperidine 2783:2-Benzylpiperidine 2188:Indanylamphetamine 1283:4-Methylpentedrone 1268:4-Methylbuphedrone 685:2010-11-04 at the 252:Adrenergic agonist 4256: 4255: 4185:Methylscopolamine 4142:Ophthalmologicals 4108: 4107: 3889: 3888: 3729:preparations and 3692: 3691: 3631:Rubidium chloride 3102:Altropane (IACFT) 3016:Indapyrophenidone 2838:Methylnaphthidate 2599:Phenylmorpholines 2519:Propylamphetamine 2398: 2210: 1999: 1887:Dextroamphetamine 1378:N-Ethylbuphedrone 1318:Dimethylcathinone 1273:4-Methylcathinone 1031:Methylhexaneamine 654:978-0-7295-8853-9 499:Erythroxylum coca 428:Parasympatholytic 380:psychoactive drug 146:neurotransmitters 99:adrenergic amines 16:(Redirected from 4276: 4269:Sympathomimetics 4215:Sympathomimetics 4163:Anticholinergics 4135: 4128: 4121: 4112: 4111: 3792: 3791: 3744:Sympathomimetics 3719: 3712: 3705: 3696: 3695: 3112:CFT (WIN 35,428) 3097:4'-Fluorococaine 2961:Diphenylprolinol 2828:Ethylnaphthidate 2823:Diphenylpyraline 2459:Phenpromethamine 2396: 2331:Methoxyphenamine 2321:Methoxyphenamine 2222:Lisdexamfetamine 2208: 2122:Levofenfluramine 1997: 1957:Chlorphentermine 1690:4-Methylaminorex 1383:N-Ethylhexedrone 867: 860: 853: 844: 843: 821: 820: 803:(6): 1494–1496. 788: 782: 781: 749: 743: 742: 740: 739: 725: 719: 718: 710: 704: 703: 695: 689: 677: 671: 670: 638: 613:Adrenergic storm 559:4-methylaminorex 532:(Ecstasy, Molly) 518:lisdexamfetamine 464:benzylpiperazine 294:Dopamine agonist 160:, or even delay 95:adrenergic drugs 78: 62: 46: 21: 18:Sympathomimetics 4284: 4283: 4279: 4278: 4277: 4275: 4274: 4273: 4259: 4258: 4257: 4252: 4209: 4167:antimuscarinics 4157: 4139: 4109: 4104: 4063: 4007: 3996: 3948: 3898: 3885: 3837: 3813: 3781: 3738: 3725:Drugs used for 3723: 3693: 3688: 3675: 3576:Methiopropamine 3349: 3276: 3202:RTI-121 (IPCIT) 3078: 3069:Phenylpiracetam 3050: 2892: 2878:Propylphenidate 2853:Methylphenidate 2813:Desoxypipradrol 2764: 2676: 2652:Phendimetrazine 2593: 2569:Tranylcypromine 2524:Pseudoephedrine 2391:Normetanephrine 2386:Norfenfluramine 2302:Methamphetamine 2118:Dexfenfluramine 1891:Levoamphetamine 1873:2-Aminotetralin 1735:Phenethylamines 1729: 1676: 1633: 1575: 1402: 1343:Isoethcathinone 1234: 1201: 1133: 1050: 1041:Propylhexedrine 987: 914: 876: 871: 829: 824: 789: 785: 750: 746: 737: 735: 727: 726: 722: 711: 707: 696: 692: 687:Wayback Machine 678: 674: 655: 639: 635: 631: 609: 596:pseudoephedrine 590:propylhexedrine 553:methylphenidate 536:methamphetamine 448: 424: 416:methamphetamine 408:pseudoephedrine 390:, and possibly 384:abuse potential 342: 340:Abuse potential 334:propylhexedrine 322: 316: 314:Indirect-acting 296: 290: 269: 254: 248: 243: 212: 204:COMT inhibitors 184: 162:premature labor 93:(also known as 88: 87: 86: 85: 84: 79: 70: 69: 68: 63: 54: 53: 52: 47: 38: 37: 28: 23: 22: 15: 12: 11: 5: 4282: 4272: 4271: 4254: 4253: 4251: 4250: 4245: 4235: 4230: 4225: 4219: 4217: 4211: 4210: 4208: 4207: 4204:+phenylephrine 4197: 4192: 4190:Cyclopentolate 4187: 4182: 4177: 4171: 4169: 4159: 4158: 4138: 4137: 4130: 4123: 4115: 4106: 4105: 4103: 4102: 4097: 4092: 4082: 4077: 4071: 4069: 4065: 4064: 4062: 4061: 4056: 4046: 4041: 4036: 4022: 4011: 4009: 4005: 3998: 3997: 3995: 3994: 3989: 3984: 3979: 3974: 3969: 3964: 3958: 3956: 3950: 3949: 3947: 3946: 3941: 3931: 3926: 3912: 3906: 3904: 3891: 3890: 3887: 3886: 3884: 3883: 3878: 3872: 3867: 3858: 3853: 3847: 3845: 3839: 3838: 3836: 3835: 3830: 3824: 3822: 3815: 3814: 3812: 3811: 3806: 3800: 3798: 3789: 3783: 3782: 3780: 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3051: 3049: 3048: 3043: 3038: 3033: 3028: 3023: 3018: 3013: 3008: 3003: 2998: 2993: 2988: 2983: 2978: 2973: 2968: 2963: 2958: 2953: 2948: 2943: 2938: 2933: 2928: 2923: 2918: 2913: 2908: 2902: 2900: 2894: 2893: 2891: 2890: 2885: 2880: 2875: 2870: 2865: 2860: 2850: 2845: 2840: 2835: 2833:Ethylphenidate 2830: 2825: 2820: 2815: 2810: 2805: 2800: 2795: 2790: 2785: 2780: 2774: 2772: 2766: 2765: 2763: 2762: 2757: 2752: 2747: 2742: 2737: 2732: 2727: 2722: 2717: 2712: 2707: 2702: 2697: 2692: 2686: 2684: 2678: 2677: 2675: 2674: 2669: 2664: 2659: 2654: 2649: 2644: 2639: 2634: 2629: 2624: 2619: 2614: 2609: 2603: 2601: 2595: 2594: 2592: 2591: 2586: 2581: 2576: 2571: 2566: 2561: 2556: 2551: 2546: 2541: 2538:Levosalbutamol 2531: 2526: 2521: 2516: 2511: 2506: 2501: 2496: 2491: 2486: 2481: 2476: 2471: 2466: 2461: 2456: 2451: 2446: 2441: 2436: 2431: 2426: 2421: 2416: 2411: 2406: 2401: 2393: 2388: 2383: 2378: 2376:Norepinephrine 2373: 2368: 2363: 2358: 2353: 2348: 2343: 2338: 2333: 2328: 2323: 2318: 2313: 2299: 2294: 2289: 2284: 2279: 2274: 2269: 2264: 2259: 2254: 2249: 2244: 2239: 2234: 2229: 2224: 2219: 2214: 2205: 2200: 2195: 2190: 2185: 2180: 2175: 2170: 2165: 2160: 2155: 2150: 2145: 2140: 2135: 2130: 2125: 2111: 2106: 2101: 2096: 2091: 2086: 2084:Etilamfetamine 2081: 2076: 2071: 2066: 2061: 2056: 2051: 2046: 2041: 2036: 2022: 2017: 2012: 2007: 2002: 1994: 1989: 1984: 1979: 1974: 1969: 1964: 1959: 1954: 1949: 1944: 1939: 1934: 1929: 1924: 1919: 1914: 1909: 1904: 1899: 1894: 1880: 1875: 1870: 1865: 1860: 1855: 1850: 1845: 1840: 1835: 1830: 1825: 1820: 1815: 1810: 1805: 1800: 1795: 1790: 1785: 1780: 1775: 1770: 1765: 1760: 1755: 1750: 1745: 1739: 1737: 1731: 1730: 1728: 1727: 1722: 1717: 1712: 1707: 1702: 1697: 1692: 1686: 1684: 1678: 1677: 1675: 1674: 1669: 1664: 1659: 1654: 1649: 1643: 1641: 1635: 1634: 1632: 1631: 1626: 1621: 1616: 1611: 1606: 1601: 1596: 1591: 1585: 1583: 1577: 1576: 1574: 1573: 1568: 1563: 1558: 1553: 1548: 1543: 1538: 1533: 1528: 1523: 1518: 1513: 1508: 1503: 1498: 1493: 1488: 1483: 1478: 1473: 1468: 1463: 1458: 1453: 1448: 1443: 1438: 1433: 1428: 1423: 1418: 1412: 1410: 1404: 1403: 1401: 1400: 1395: 1390: 1385: 1380: 1375: 1370: 1365: 1360: 1355: 1350: 1345: 1340: 1335: 1330: 1325: 1320: 1315: 1310: 1305: 1300: 1295: 1290: 1285: 1280: 1275: 1270: 1265: 1260: 1255: 1250: 1244: 1242: 1236: 1235: 1233: 1232: 1227: 1222: 1217: 1211: 1209: 1203: 1202: 1200: 1199: 1194: 1189: 1184: 1179: 1174: 1169: 1164: 1159: 1154: 1152:Dieticyclidine 1149: 1143: 1141: 1135: 1134: 1132: 1131: 1126: 1121: 1116: 1111: 1106: 1101: 1096: 1091: 1086: 1081: 1076: 1071: 1066: 1060: 1058: 1052: 1051: 1049: 1048: 1046:Tuaminoheptane 1043: 1038: 1033: 1028: 1023: 1018: 1013: 1008: 1003: 1001:Cyclopentamine 997: 995: 989: 988: 986: 985: 980: 975: 970: 965: 963:Istradefylline 960: 955: 950: 945: 940: 935: 930: 924: 922: 916: 915: 913: 912: 907: 902: 897: 892: 886: 884: 878: 877: 870: 869: 862: 855: 847: 841: 840: 828: 827:External links 825: 823: 822: 783: 764:(5): 737–741. 744: 720: 705: 690: 672: 653: 632: 630: 627: 626: 625: 620: 615: 608: 605: 604: 603: 593: 587: 581: 575: 561: 556: 550: 544: 539: 533: 527: 521: 515: 503: 491: 479: 467: 461: 455: 447: 444: 423: 420: 365:norepinephrine 341: 338: 318:Main article: 315: 312: 292:Main article: 289: 286: 267: 250:Main article: 247: 244: 242: 239: 230: 229: 226: 223: 211: 208: 183: 180: 158:blood pressure 154:cardiac arrest 138:norepinephrine 130:catecholamines 126:blood pressure 112:. Examples of 80: 73: 72: 71: 66:Norepinephrine 64: 57: 56: 55: 48: 41: 40: 39: 35:catecholamines 32: 31: 30: 29: 26: 9: 6: 4: 3: 2: 4281: 4270: 4267: 4266: 4264: 4249: 4246: 4243: 4239: 4238:Phenylephrine 4236: 4234: 4231: 4229: 4226: 4224: 4221: 4220: 4218: 4216: 4212: 4205: 4201: 4198: 4196: 4193: 4191: 4188: 4186: 4183: 4181: 4178: 4176: 4173: 4172: 4170: 4168: 4164: 4160: 4155: 4151: 4147: 4143: 4136: 4131: 4129: 4124: 4122: 4117: 4116: 4113: 4101: 4098: 4096: 4093: 4090: 4086: 4083: 4081: 4078: 4076: 4073: 4072: 4070: 4066: 4060: 4057: 4054: 4050: 4047: 4045: 4042: 4040: 4037: 4034: 4030: 4026: 4023: 4020: 4016: 4013: 4012: 4010: 4003: 3999: 3993: 3990: 3988: 3985: 3983: 3980: 3978: 3975: 3973: 3970: 3968: 3965: 3963: 3960: 3959: 3957: 3955: 3951: 3945: 3944:Methazolamide 3942: 3939: 3935: 3932: 3930: 3929:Diclofenamide 3927: 3924: 3920: 3916: 3913: 3911: 3910:Acetazolamide 3908: 3907: 3905: 3902: 3896: 3892: 3882: 3879: 3876: 3875:Physostigmine 3873: 3871: 3868: 3866: 3862: 3859: 3857: 3854: 3852: 3849: 3848: 3846: 3844: 3840: 3834: 3831: 3829: 3828:Acetylcholine 3826: 3825: 3823: 3821: 3816: 3810: 3807: 3805: 3802: 3801: 3799: 3797: 3793: 3790: 3788: 3784: 3778: 3775: 3773: 3770: 3768: 3765: 3762: 3758: 3755: 3753: 3752:Apraclonidine 3750: 3749: 3747: 3745: 3741: 3736: 3732: 3728: 3720: 3715: 3713: 3708: 3706: 3701: 3700: 3697: 3687: 3683: 3678: 3672: 3669: 3667: 3664: 3662: 3659: 3657: 3654: 3652: 3651:Thiopropamine 3649: 3647: 3644: 3642: 3639: 3637: 3634: 3632: 3629: 3627: 3624: 3622: 3619: 3617: 3614: 3612: 3609: 3607: 3604: 3602: 3599: 3597: 3594: 3592: 3589: 3587: 3584: 3582: 3579: 3577: 3574: 3572: 3569: 3567: 3564: 3562: 3559: 3557: 3554: 3552: 3551:Meclofenoxate 3549: 3547: 3544: 3542: 3539: 3537: 3534: 3532: 3529: 3527: 3524: 3522: 3519: 3517: 3514: 3512: 3509: 3507: 3504: 3502: 3501:Hexacyclonate 3499: 3497: 3494: 3492: 3489: 3487: 3484: 3482: 3479: 3477: 3474: 3472: 3469: 3467: 3464: 3462: 3459: 3457: 3454: 3452: 3449: 3447: 3444: 3442: 3439: 3437: 3434: 3432: 3429: 3427: 3424: 3422: 3419: 3417: 3416:Centanafadine 3414: 3412: 3409: 3407: 3404: 3402: 3399: 3397: 3394: 3392: 3389: 3387: 3384: 3382: 3379: 3377: 3374: 3372: 3369: 3367: 3364: 3362: 3359: 3358: 3356: 3352: 3346: 3343: 3341: 3338: 3336: 3333: 3331: 3328: 3326: 3323: 3321: 3318: 3316: 3313: 3311: 3308: 3306: 3303: 3301: 3298: 3296: 3293: 3291: 3288: 3287: 3285: 3283: 3279: 3273: 3270: 3268: 3265: 3263: 3260: 3258: 3255: 3253: 3250: 3248: 3245: 3243: 3240: 3238: 3235: 3233: 3230: 3228: 3225: 3223: 3220: 3218: 3215: 3213: 3210: 3208: 3205: 3203: 3200: 3198: 3195: 3193: 3190: 3188: 3185: 3183: 3180: 3178: 3175: 3173: 3170: 3168: 3165: 3163: 3160: 3158: 3155: 3153: 3152:Ioflupane (I) 3150: 3148: 3145: 3143: 3140: 3138: 3135: 3133: 3130: 3128: 3125: 3123: 3120: 3118: 3115: 3113: 3110: 3108: 3105: 3103: 3100: 3098: 3095: 3093: 3090: 3089: 3087: 3085: 3081: 3075: 3072: 3070: 3067: 3065: 3062: 3061: 3059: 3057: 3053: 3047: 3044: 3042: 3039: 3037: 3034: 3032: 3029: 3027: 3024: 3022: 3019: 3017: 3014: 3012: 3009: 3007: 3004: 3002: 2999: 2997: 2994: 2992: 2989: 2987: 2984: 2982: 2979: 2977: 2974: 2972: 2969: 2967: 2964: 2962: 2959: 2957: 2954: 2952: 2949: 2947: 2944: 2942: 2939: 2937: 2934: 2932: 2929: 2927: 2924: 2922: 2919: 2917: 2914: 2912: 2909: 2907: 2904: 2903: 2901: 2899: 2895: 2889: 2886: 2884: 2881: 2879: 2876: 2874: 2871: 2869: 2868:Phacetoperane 2866: 2864: 2861: 2858: 2854: 2851: 2849: 2846: 2844: 2841: 2839: 2836: 2834: 2831: 2829: 2826: 2824: 2821: 2819: 2816: 2814: 2811: 2809: 2806: 2804: 2801: 2799: 2796: 2794: 2791: 2789: 2786: 2784: 2781: 2779: 2776: 2775: 2773: 2771: 2767: 2761: 2758: 2756: 2753: 2751: 2748: 2746: 2743: 2741: 2738: 2736: 2733: 2731: 2728: 2726: 2723: 2721: 2718: 2716: 2713: 2711: 2708: 2706: 2703: 2701: 2698: 2696: 2693: 2691: 2688: 2687: 2685: 2683: 2679: 2673: 2670: 2668: 2665: 2663: 2660: 2658: 2657:Phenmetrazine 2655: 2653: 2650: 2648: 2645: 2643: 2640: 2638: 2635: 2633: 2630: 2628: 2625: 2623: 2620: 2618: 2615: 2613: 2610: 2608: 2605: 2604: 2602: 2600: 2596: 2590: 2587: 2585: 2584:Xylopropamine 2582: 2580: 2577: 2575: 2572: 2570: 2567: 2565: 2562: 2560: 2559:Theodrenaline 2557: 2555: 2552: 2550: 2547: 2545: 2542: 2539: 2535: 2532: 2530: 2527: 2525: 2522: 2520: 2517: 2515: 2512: 2510: 2507: 2505: 2502: 2500: 2497: 2495: 2492: 2490: 2487: 2485: 2482: 2480: 2477: 2475: 2474:Phenylephrine 2472: 2470: 2469:Phenylalanine 2467: 2465: 2462: 2460: 2457: 2455: 2452: 2450: 2447: 2445: 2442: 2440: 2437: 2435: 2432: 2430: 2427: 2425: 2422: 2420: 2417: 2415: 2412: 2410: 2409:Orciprenaline 2407: 2405: 2402: 2400: 2394: 2392: 2389: 2387: 2384: 2382: 2379: 2377: 2374: 2372: 2369: 2367: 2364: 2362: 2359: 2357: 2354: 2352: 2349: 2347: 2344: 2342: 2339: 2337: 2334: 2332: 2329: 2327: 2324: 2322: 2319: 2317: 2314: 2311: 2307: 2303: 2300: 2298: 2295: 2293: 2290: 2288: 2285: 2283: 2282:Mephentermine 2280: 2278: 2275: 2273: 2270: 2268: 2265: 2263: 2260: 2258: 2255: 2253: 2250: 2248: 2245: 2243: 2240: 2238: 2235: 2233: 2230: 2228: 2225: 2223: 2220: 2218: 2215: 2212: 2206: 2204: 2201: 2199: 2196: 2194: 2191: 2189: 2186: 2184: 2181: 2179: 2176: 2174: 2171: 2169: 2166: 2164: 2161: 2159: 2156: 2154: 2151: 2149: 2146: 2144: 2141: 2139: 2136: 2134: 2131: 2129: 2126: 2123: 2119: 2115: 2112: 2110: 2107: 2105: 2102: 2100: 2097: 2095: 2092: 2090: 2087: 2085: 2082: 2080: 2077: 2075: 2072: 2070: 2067: 2065: 2062: 2060: 2057: 2055: 2052: 2050: 2047: 2045: 2042: 2040: 2037: 2034: 2030: 2026: 2023: 2021: 2018: 2016: 2013: 2011: 2008: 2006: 2003: 2001: 1995: 1993: 1990: 1988: 1985: 1983: 1980: 1978: 1975: 1973: 1970: 1968: 1965: 1963: 1960: 1958: 1955: 1953: 1950: 1948: 1945: 1943: 1940: 1938: 1935: 1933: 1930: 1928: 1925: 1923: 1922:Benzphetamine 1920: 1918: 1915: 1913: 1910: 1908: 1905: 1903: 1900: 1898: 1895: 1892: 1888: 1884: 1881: 1879: 1876: 1874: 1871: 1869: 1866: 1864: 1863:2-Aminoindane 1861: 1859: 1856: 1854: 1851: 1849: 1846: 1844: 1841: 1839: 1836: 1834: 1831: 1829: 1826: 1824: 1821: 1819: 1816: 1814: 1811: 1809: 1806: 1804: 1801: 1799: 1796: 1794: 1791: 1789: 1786: 1784: 1781: 1779: 1776: 1774: 1771: 1769: 1766: 1764: 1761: 1759: 1756: 1754: 1751: 1749: 1746: 1744: 1741: 1740: 1738: 1736: 1732: 1726: 1723: 1721: 1718: 1716: 1713: 1711: 1708: 1706: 1703: 1701: 1698: 1696: 1693: 1691: 1688: 1687: 1685: 1683: 1679: 1673: 1670: 1668: 1665: 1663: 1660: 1658: 1655: 1653: 1650: 1648: 1645: 1644: 1642: 1640: 1636: 1630: 1627: 1625: 1622: 1620: 1617: 1615: 1612: 1610: 1607: 1605: 1602: 1600: 1597: 1595: 1592: 1590: 1587: 1586: 1584: 1582: 1578: 1572: 1569: 1567: 1564: 1562: 1559: 1557: 1554: 1552: 1549: 1547: 1544: 1542: 1539: 1537: 1534: 1532: 1529: 1527: 1524: 1522: 1519: 1517: 1514: 1512: 1509: 1507: 1504: 1502: 1499: 1497: 1494: 1492: 1489: 1487: 1484: 1482: 1479: 1477: 1474: 1472: 1469: 1467: 1464: 1462: 1459: 1457: 1454: 1452: 1449: 1447: 1444: 1442: 1439: 1437: 1434: 1432: 1429: 1427: 1424: 1422: 1419: 1417: 1414: 1413: 1411: 1409: 1405: 1399: 1396: 1394: 1391: 1389: 1386: 1384: 1381: 1379: 1376: 1374: 1371: 1369: 1366: 1364: 1361: 1359: 1356: 1354: 1353:Methcathinone 1351: 1349: 1346: 1344: 1341: 1339: 1336: 1334: 1331: 1329: 1326: 1324: 1321: 1319: 1316: 1314: 1311: 1309: 1306: 1304: 1301: 1299: 1296: 1294: 1291: 1289: 1286: 1284: 1281: 1279: 1276: 1274: 1271: 1269: 1266: 1264: 1261: 1259: 1256: 1254: 1251: 1249: 1246: 1245: 1243: 1241: 1237: 1231: 1228: 1226: 1223: 1221: 1218: 1216: 1213: 1212: 1210: 1208: 1204: 1198: 1195: 1193: 1192:Tenocyclidine 1190: 1188: 1187:Rolicyclidine 1185: 1183: 1182:Phencyclidine 1180: 1178: 1177:Phencyclamine 1175: 1173: 1170: 1168: 1165: 1163: 1160: 1158: 1155: 1153: 1150: 1148: 1147:Benocyclidine 1145: 1144: 1142: 1140: 1136: 1130: 1127: 1125: 1122: 1120: 1117: 1115: 1112: 1110: 1107: 1105: 1102: 1100: 1097: 1095: 1092: 1090: 1087: 1085: 1082: 1080: 1077: 1075: 1072: 1070: 1067: 1065: 1062: 1061: 1059: 1057: 1053: 1047: 1044: 1042: 1039: 1037: 1034: 1032: 1029: 1027: 1024: 1022: 1021:Isometheptene 1019: 1017: 1014: 1012: 1009: 1007: 1004: 1002: 999: 998: 996: 994: 990: 984: 981: 979: 976: 974: 971: 969: 966: 964: 961: 959: 956: 954: 951: 949: 946: 944: 943:Aminophylline 941: 939: 936: 934: 931: 929: 926: 925: 923: 921: 917: 911: 908: 906: 903: 901: 898: 896: 893: 891: 888: 887: 885: 883: 879: 875: 868: 863: 861: 856: 854: 849: 848: 845: 838: 834: 831: 830: 818: 814: 810: 806: 802: 798: 794: 787: 779: 775: 771: 767: 763: 759: 755: 748: 734: 730: 724: 716: 709: 701: 694: 688: 684: 681: 676: 669: 664: 660: 656: 650: 646: 645: 637: 633: 624: 623:Sympatholytic 621: 619: 616: 614: 611: 610: 601: 597: 594: 591: 588: 585: 584:phenmetrazine 582: 579: 576: 573: 569: 565: 564:oxymetazoline 562: 560: 557: 554: 551: 548: 545: 543: 542:methcathinone 540: 537: 534: 531: 528: 525: 522: 519: 516: 513: 512: 507: 504: 501: 500: 495: 492: 489: 488: 483: 480: 477: 476: 471: 468: 465: 462: 459: 458:benzphetamine 456: 453: 450: 449: 443: 441: 437: 436:accommodation 433: 429: 419: 417: 413: 409: 403: 401: 397: 393: 389: 386:, can induce 385: 381: 377: 373: 368: 366: 362: 358: 354: 350: 346: 345:Illegal drugs 337: 335: 331: 327: 321: 311: 309: 305: 301: 295: 285: 283: 279: 278:isoproterenol 275: 274:phenylephrine 271: 263: 259: 253: 241:Direct-acting 238: 235: 227: 224: 221: 220: 219: 216: 207: 205: 201: 197: 193: 189: 179: 177: 173: 170: 165: 163: 159: 155: 151: 147: 143: 139: 135: 131: 127: 123: 119: 115: 111: 107: 104: 100: 96: 92: 83: 77: 67: 61: 51: 45: 36: 19: 4214: 4089:+latanoprost 4080:Guanethidine 4068:Other agents 3982:Metipranolol 3923:+brimonidine 3915:Brinzolamide 3901:sulfonamides 3865:Fluostigmine 3743: 3606:Oxaprotiline 3556:Medifoxamine 3476:Fenpentadiol 3456:Dimethocaine 3451:Diclofensine 3431:Cropropamide 3426:Clofenciclan 3381:Amiphenazole 3335:7-Methyl-αET 3330:6-Fluoro-αMT 3310:5-Fluoro-αMT 3305:5-Chloro-αMT 3300:4-Methyl-αMT 3295:4-Methyl-αET 3137:Difluoropine 3122:Cocaethylene 3107:Brasofensine 3046:Pyrovalerone 2898:Pyrrolidines 2617:Fenmetramide 2612:Fenbutrazate 2589:Zylofuramine 2549:Solriamfetol 2381:Norfenefrine 2287:Metanephrine 2213:(Selegiline) 2203:Isoprenaline 2133:Feprosidnine 2114:Fenfluramine 2109:Fenethylline 2094:Famprofazone 1967:Cinnamedrine 1897:Amphetaminil 1848:Amfepentorex 1526:Sazetidine A 1491:Ispronicline 1456:Bradanicline 1408:Cholinergics 1323:Ethcathinone 1207:Benzazepines 1162:Eticyclidine 983:Theophylline 968:Paraxanthine 800: 796: 786: 761: 757: 747: 736:. Retrieved 732: 723: 714: 708: 699: 693: 675: 666: 643: 636: 599: 509: 497: 487:Catha edulis 485: 475:Catha edulis 473: 425: 404: 369: 355:also affect 343: 323: 297: 255: 231: 217: 213: 185: 169:postsynaptic 166: 113: 98: 94: 90: 89: 4200:Tropicamide 4195:Homatropine 4180:Scopolamine 4150:cycloplegia 4075:Dapiprazole 4059:Unoprostone 4029:+netarsudil 4025:Latanoprost 4015:Bimatoprost 3977:Levobunolol 3934:Dorzolamide 3870:Neostigmine 3856:Ecothiopate 3818:muscarinic/ 3809:Pilocarpine 3777:Epinephrine 3772:Dipivefrine 3757:Brimonidine 3656:Thiothinone 3641:Tametraline 3626:Rauwolscine 3596:Nomifensine 3591:Nikethamide 3536:Lomevactone 3521:JNJ-7925476 3516:Indatraline 3491:GSK1360707F 3446:Desipramine 3436:Crotetamide 3421:Ciclazindol 3401:Benzydamine 3391:Atomoxetine 3386:Atipamezole 3282:Tryptamines 3252:Tesofensine 2818:Difemetorex 2770:Piperidines 2682:Piperazines 2544:Sibutramine 2514:Prenylamine 2464:Phentermine 2419:Oxifentorex 2316:Methoxamine 2292:Metaraminol 2128:Fenproporex 2099:Fencamfamin 2064:Epinephrine 1987:Clortermine 1977:Clobenzorex 1972:Clenbuterol 1947:Camfetamine 1883:Amphetamine 1853:Amidephrine 1725:Thozalinone 1705:Cyclazodone 1652:Armodafinil 1614:Pentetrazol 1594:Bicuculline 1581:Convulsants 1571:WAY-317,538 1566:Varenicline 1556:Tebanicline 1536:SSR-180,711 1521:Rivanicline 1516:Pozanicline 1511:PNU-282,987 1506:PNU-120,596 1501:PHA-543,613 1481:Epiboxidine 1476:Epibatidine 1441:Altinicline 1333:Flephedrone 1288:Amfepramone 1167:Gacyclidine 1011:Cyprodenate 993:Alkylamines 978:Theobromine 910:Rimantadine 882:Adamantanes 592:(Benzedrex) 572:Vicks Sinex 524:maprotiline 452:amphetamine 440:cycloplegia 326:amphetamine 300:D1 receptor 134:epinephrine 50:Epinephrine 4248:Pholedrine 4242:+ketorolac 4095:Omidenepag 4085:Netarsudil 4049:Travoprost 4044:Tafluprost 3992:Mepindolol 3851:Demecarium 3804:Aceclidine 3796:muscarinic 3636:Setazindol 3621:Rasagiline 3611:PNU-99,194 3561:Mefexamide 3531:Leptacline 3526:Lazabemide 3496:GYKI-52895 3486:Gilutensin 3411:BTS 74,398 3376:Amineptine 3325:5-MeO-DIPT 3157:Norcocaine 3147:FP-β-CPPIT 3142:FE-β-CPPIT 3064:Oxiracetam 3041:Prolintane 2760:Vanoxerine 2672:Radafaxine 2647:PD-128,907 2642:Oxaflozane 2627:Manifaxine 2554:Synephrine 2534:Salbutamol 2529:Ropinirole 2484:Pholedrine 2424:Oxilofrine 2414:Ortetamine 2404:Octopamine 2371:Nisoxetine 2227:Lophophine 2217:Lefetamine 2198:Isoetarine 2193:Iofetamine 2158:Hexapradol 2148:Furfenorex 2143:Formetorex 2089:Etilefrine 2074:Etafedrine 2044:Dopexamine 2029:Dextrodopa 2020:Dobutamine 2005:Denopamine 1992:Cypenamine 1962:Cilobamine 1917:Benfluorex 1902:Arbutamine 1843:Amfecloral 1833:Alfetamine 1715:Fluminorex 1710:Fenozolone 1700:Clominorex 1682:Oxazolines 1662:CRL-40,941 1657:CRL-40,940 1624:Strychnine 1619:Picrotoxin 1589:Anatoxin-a 1471:Dianicline 1388:Pentedrone 1358:Methedrone 1348:Mephedrone 1298:Buphedrone 1293:Benzedrone 1240:Cathinones 1197:Tiletamine 1157:Esketamine 1099:LY-503,430 1094:LY-404,187 1016:Heptaminol 1006:Cypenamine 958:Dimethazan 900:Bromantane 895:Amantadine 890:Adapromine 874:Stimulants 758:Pediatrics 738:2021-11-21 663:1287761421 629:References 586:(Preludin) 526:(Ludiomil) 508:(found in 496:(found in 484:(found in 472:(found in 422:Comparison 376:stimulants 304:fenoldopam 282:dobutamine 262:Salbutamol 118:heart rate 103:endogenous 4233:Ibopamine 4223:Ephedrine 4146:mydriasis 4100:Ripasudil 3972:Carteolol 3967:Betaxolol 3962:Befunolol 3833:Carbachol 3820:nicotinic 3767:Clonidine 3671:Yohimbine 3646:Tandamine 3616:PRC200-SS 3511:Indanorex 3481:Gamfexine 3471:Fenisorex 3396:Bemegride 3320:5-MeO-αMT 3315:5-MeO-αET 3262:Tropoxane 3036:Picilorex 3026:Naphyrone 2873:Pipradrol 2735:GBR-13119 2730:GBR-13098 2725:GBR-13069 2720:GBR-12935 2715:GBR-12783 2454:Phenatine 2277:Mefenorex 2211:-Deprenyl 2183:Ibopamine 2168:Hordenine 2153:Gepefrine 2104:Fencamine 2059:Ephedrine 2049:Droxidopa 2000:-Deprenyl 1878:Acridorex 1672:Modafinil 1667:Fluorenol 1647:Adrafinil 1639:Eugeroics 1604:Flurothyl 1531:SIB-1553A 1451:Arecoline 1446:Anabasine 1436:AR-R17779 1421:A-366,833 1393:Pentylone 1373:Mexedrone 1368:Methylone 1338:Hexedrone 1313:Cathinone 1303:Bupropion 1230:SKF-82958 1225:SKF-81297 1220:SKF-77434 1124:Sunifiram 1109:Org 26576 1104:Nooglutyl 1056:Ampakines 1036:Octodrine 973:SCH-58261 953:CGS-15943 905:Memantine 817:0361-803X 778:0031-4005 733:Drugs.com 668:pressure. 555:(Ritalin) 520:(Vyvanse) 506:ephedrine 482:cathinone 432:mydriasis 396:sedatives 388:tolerance 361:serotonin 330:ephedrine 172:receptors 4263:Category 4175:Atropine 4053:+timolol 4033:+timolol 4019:+timolol 3938:+timolol 3919:+timolol 3881:Paraoxon 3861:Stigmine 3761:+timolol 3727:glaucoma 3682:ATC code 3546:Mazindol 3506:Idazoxan 3466:Etamivan 3461:Efaroxan 3290:4-HO-αMT 3084:Tropanes 3056:Racetams 2911:4-Cl-PVP 2888:SCH-5472 2848:JZ-IV-10 2740:JJC8-088 2690:2C-B-BZP 2637:Morforex 2632:Morazone 2579:Tyrosine 2574:Tyramine 2564:Tiflorex 2449:Pentorex 2351:Morforex 2297:Mesocarb 2138:Fludorex 2039:Dopamine 2033:Levodopa 1982:Cloforex 1763:2-OH-PEA 1720:Pemoline 1695:Aminorex 1609:Gabazine 1496:Nicotine 1466:Cytisine 1461:Cotinine 1416:A-84,543 1328:Ethylone 1308:Butylone 1253:3,4-DMMC 1215:6-Br-APB 1172:Ketamine 1129:Unifiram 948:Caffeine 683:Archived 607:See also 602:species) 580:(Cylert) 578:pemoline 460:(Didrex) 454:(Evekeo) 446:Examples 357:dopamine 347:such as 270:-agonist 176:reuptake 156:and low 150:hormones 142:dopamine 106:agonists 82:Dopamine 3987:Timolol 3661:Trazium 3586:Nefopam 3541:LR-5182 3242:RTI-386 3237:RTI-371 3232:RTI-354 3227:RTI-336 3222:RTI-229 3217:RTI-177 3212:RTI-150 3207:RTI-126 3197:RTI-120 3192:RTI-113 3187:RTI-112 3127:Cocaine 2916:5-DBFPV 2863:Nocaine 2710:DBL-583 2069:Epinine 1952:Cathine 1828:AL-1095 1773:2,3-MDA 1629:Thujone 1551:TC-2216 1546:TC-1827 1541:TC-1698 1431:ABT-418 1426:ABT-202 1119:S-18986 1089:IDRA-21 700:Biology 600:Ephedra 511:Ephedra 502:, coca) 494:cocaine 490:, khat) 470:cathine 349:cocaine 132:(i.e., 108:of the 3731:miosis 3666:UH-232 3601:O-2172 3354:Others 3182:RTI-51 3177:RTI-32 3172:RTI-31 2946:α-PHPP 2936:α-PHiP 2931:α-PCYP 2695:3C-PEP 2257:MDMPEA 1561:UB-165 1486:GTS-21 1278:4-MEAP 1084:CX-717 1079:CX-691 1074:CX-614 1069:CX-546 1064:CX-516 839:(MeSH) 815:  776:  661:  651:  549:(MDPV) 363:, and 332:, and 280:, and 194:, and 140:, and 124:, and 3441:D-161 3361:2-MDP 3272:WF-33 3267:WF-23 3011:MOPPP 3006:MOPVP 2986:MDPBP 2981:MDPPP 2966:DMPVP 2956:α-PVT 2951:α-PVP 2941:α-PHP 2926:α-PBP 2921:α-PPP 2745:MeOPP 2705:CM156 2622:G-130 2341:MMDMA 2272:MDPEA 1823:6-FNE 1818:4-MTA 1813:4-MMA 1263:4-CMC 1258:4-BMC 568:Afrin 466:(BZP) 378:(see 234:amine 200:MAOIs 4154:S01F 4148:and 3735:S01E 3686:N06B 3021:MDPV 3001:MPPP 2996:MPHP 2991:MPBP 2976:FPVP 2971:FPOP 2755:oMPP 2750:MBZP 2509:PPAP 2504:PMMA 2499:PMEA 2439:PCMA 2346:MMMA 2336:MMDA 2267:MDPR 2262:MDOH 2247:MDEA 2242:MDBU 2232:MBDB 2163:HMMA 2054:EBDB 2025:DOPA 1942:BPAP 1808:4-MA 1599:DMCM 1114:PEPA 813:ISSN 774:ISSN 659:OCLC 649:ISBN 530:MDMA 353:MDMA 351:and 148:and 97:and 3406:BTQ 3345:αMT 3340:αET 3167:PTT 3162:PIT 3031:PEP 2700:BZP 2494:PMA 2489:PIA 2444:PHA 2434:PCA 2429:PBA 2326:MMA 1932:BOH 1927:BDB 805:doi 801:173 766:doi 4265:: 4144:: 4031:, 4006:2α 4004:(F 3921:, 3684:: 2308:, 2120:, 2031:, 1889:, 811:. 799:. 795:. 772:. 762:83 760:. 756:. 731:. 665:. 657:. 570:, 414:, 410:, 402:. 367:. 359:, 328:, 310:. 284:. 276:, 202:, 190:, 136:, 120:, 4244:) 4240:( 4206:) 4202:( 4165:/ 4156:) 4152:( 4134:e 4127:t 4120:v 4091:) 4087:( 4055:) 4051:( 4035:) 4027:( 4021:) 4017:( 4008:) 3940:) 3936:( 3925:) 3917:( 3903:) 3899:( 3897:/ 3877:) 3863:( 3763:) 3759:( 3737:) 3733:( 3718:e 3711:t 3704:v 2859:) 2855:( 2540:) 2536:( 2397:L 2312:) 2304:( 2209:L 2124:) 2116:( 2035:) 2027:( 1998:D 1893:) 1885:( 866:e 859:t 852:v 819:. 807:: 780:. 768:: 741:. 574:) 566:( 514:) 478:) 438:( 426:" 268:2 266:β 20:)

Index

Sympathomimetics
catecholamines

Epinephrine

Norepinephrine

Dopamine
endogenous
agonists
sympathetic nervous system
heart rate
force of cardiac contraction
blood pressure
catecholamines
epinephrine
norepinephrine
dopamine
neurotransmitters
hormones
cardiac arrest
blood pressure
premature labor
postsynaptic
receptors
reuptake
α-adrenergic agonists
β-adrenergic agonists
dopaminergic agonists
MAOIs

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