31:
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313:, and modENCODE projects to characterize the genes, non-coding elements, and circuits of the human genome and model organisms. A major focus of his work is understanding the effects of genetic variations on human disease, with contributions to obesity, diabetes, Alzheimer's disease, schizophrenia, and cancer.
333:, professor at MIT and received the Sprowls award for the best doctorate thesis in Computer Science, and the first Paris Kanellakis graduate fellowship. Prior to computational biology, he worked on artificial intelligence, sketch and image recognition, robotics, and computational geometry, at MIT and at the
412:
in 2015. They showed that immune cell activation and inflammation, which have long been associated with the condition, are not simply the result of neurodegeneration, as some researchers have argued. Rather, in mice engineered to develop
Alzheimer’s-like symptoms, they found that immune cells start
375:
Kellis co-led the NIH government-funded project to catalogue the human epigenome. He said during an interview with MIT Technology Review “If the genome is the book of life, the epigenome is the complete set of annotations and bookmarks.” His lab now uses this map to further the understanding of
534:
committee, the Athens
Information Technology (AIT) Niki Award for Science and Engineering, the Ruth and Joel Spira Teaching award, and the George M. Sprowls Award for the best Ph.D. thesis in Computer Science at MIT. He was named as one of Technology Review's Top 35 Innovators Under 35 for his
496:
course at MIT, titled "Computational
Biology: Genomes, Networks, Evolution." The course (6.047/6.878) is geared towards advanced undergraduate and early graduate students, seeking to learn the algorithmic and machine learning foundations of computational biology, and also be exposed to current
437:
Kellis is a member of the
Genotype-Tissue Expression (GTEx) project that seeks to elucidate the basis of disease predisposition. It is an NIH-sponsored project that seeks to characterize genetic variation in human tissues with roles in diabetes, heart disease, and cancer.
550:
TEDx
Cambridge, 2013 "MIT Computational Biologist Manolis Kellis gives us a glimpse of the doctor’s office visit of the future, and uses his own genetic mutations to show itus how a revolution in genomics is unlocking treatments that could transform medicine as we know
573:, Reddit Science AMA Series: "I’m Manolis Kellis, a professor of computer science at MIT studying the human genome to learn about what causes obesity, Alzheimer’s, cancer and other conditions. AMA about comp-bio and epigenomics, and how they impact human health".
366:
He turned from yeast to flies and ultimately to mammals, comparing multiple species to explore genes, their control elements, and their deregulation in human disease. Kellis led several comparative genomics projects in human, mammals, flies, and yeast.
505:
This course is aimed at exploring the computational challenges associated with interpreting how sequence differences between individuals lead to phenotypic differences such as gene expression, disease predisposition, or response to treatment.
2239:
Pineda, S. Sebastian; Lee, Hyeseung; Fitzwalter, Brent E.; Mohammadi, Shahin; Pregent, Luc J.; Gardashli, Mahammad E.; Mantero, Julio; Engelberg-Cook, Erica; DeJesus-Hernandez, Mariely; Blitterswijk, Marka van; Pottier, Cyril (2021-07-07).
362:
in 2003, he developed computational methods to pinpoint patterns of similarity and difference between closely related genomes. The goal was to develop methods for understanding genomes with a view to apply them to the human genome.
2668:
345:
As of July 2018, Manolis Kellis has authored 187 journal publications that have been cited 68,380 times. He has helped direct several large-scale genomics projects, including the
Roadmap Epigenomics project, the
304:
Roadmap
Epigenomics Project effort to create a comprehensive map of the human epigenome, the comparative analysis of 29 mammals to create a comprehensive map of conserved elements in the human genome, the
2186:
Linna-Kuosmanen, Suvi; Schmauch, Eloi; Galani, Kyriakitsa; Boix, Carles A.; Hou, Lei; Örd, Tiit; Toropainen, Anu; Stolze, Lindsey K.; Meibalan, Elamaran; Mantero, Julio C.; Renfro, Ashley (2021-06-24).
388:. They showed that this mechanism operates in the fat cells of both humans and mice and detailed how changes within the relevant genomic regions cause a shift from dissipating energy as heat (
1505:
Hornshøj, Henrik; Nielsen, Morten Muhlig; Sinnott-Armstrong, Nicholas A.; Świtnicki, Michał P.; Juul, Malene; Madsen, Tobias; Sallari, Richard; Kellis, Manolis; Ørntoft, Torben (2018-01-11).
2388:
1088:
Consortium, The modENCODE; Roy, Sushmita; Ernst, Jason; Kharchenko, Peter V.; Kheradpour, Pouya; Negre, Nicolas; Eaton, Matthew L.; Landolin, Jane M.; Bristow, Christopher A. (2010-12-24).
560:
Welcome Trust, 2014 "Manolis Kellis, Massachusetts
Institute of Technology, USA, gives one of the keynote lectures at Epigenomics of Common Diseases, (28-31 October 2014), organised by the
1792:
Kellis, Manolis; Patterson, Nick; Endrizzi, Matthew; Birren, Bruce; Lander, Eric S. (2003). "Sequencing and comparison of yeast species to identify genes and regulatory elements".
2005:
Stark, Alexander; Lin, Michael F.; Kheradpour, Pouya; Pedersen, Jakob S.; Parts, Leopold; Carlson, Joseph W.; Crosby, Madeline A.; Rasmussen, Matthew D.; Kellis, Manolis (2007).
956:
Kellis, Manolis; Wold, Barbara; Snyder, Michael P.; Bernstein, Bradley E.; Kundaje, Anshul; Marinov, Georgi K.; Ward, Lucas D.; Birney, Ewan; Crawford, Gregory E. (2014-04-29).
1302:
Onengut-Gumuscu, Suna; Chen, Wei-Min; Burren, Oliver; Cooper, Nick J; Quinlan, Aaron R; Mychaleckyj, Josyf C; Farber, Emily; Bonnie, Jessica K; Kellis, Manolis (2015-03-09).
1242:
Claussnitzer, Melina; Dankel, Simon N.; Kim, Kyoung-Han; Quon, Gerald; Meuleman, Wouter; Haugen, Christine; Glunk, Viktoria; Sousa, Isabel S.; Kellis, Manolis (2015-09-03).
515:
112:
266:
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Kellis, Manolis; Birren, Bruce W.; Lander, Eric S. (2004-03-07). "Proof and evolutionary analysis of ancient genome duplication in the yeast
Saccharomyces cerevisiae".
1948:
Lin, Michael F.; Carlson, Joseph W.; Crosby, Madeline A.; Matthews, Beverley B.; Yu, Charles; Park, Soo; Wan, Kenneth H.; Schroeder, Andrew J.; Kellis, Manolis (2007).
751:
Kundaje, Anshul; Meuleman, Wouter; Ernst, Jason; Bilenky, Misha; Yen, Angela; Heravi-Moussavi, Alireza; Kheradpour, Pouya; Zhang, Zhizhuo; Kellis, Manolis (2015).
1023:
Ernst, Jason; Kheradpour, Pouya; Mikkelsen, Tarjei S.; Shoresh, Noam; Ward, Lucas D.; Epstein, Charles B.; Zhang, Xiaolan; Wang, Li; Issner, Robbyn (2011-03-23).
392:) to storing energy as fat. A full understanding of the phenomenon may lead to treatments for people whose 'slow metabolism' cause them to gain excessive weight.
1158:
2643:
867:
Lindblad-Toh, Kerstin; Garber, Manuel; Zuk, Or; Lin, Michael F.; Parker, Brian J.; Washietl, Stefan; Kheradpour, Pouya; Ernst, Jason; Kellis, Manolis (2011).
2648:
1589:
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30:
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Kellis and colleagues used epigenomic data to investigate the mechanistic basis of the strongest genetic association with obesity, published in the
1696:
1507:"Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival"
498:
2364:
2189:"Single-cell dissection of live human hearts in ischemic heart disease and heart failure reveals cell-type-specific driver genes and pathways"
2628:
1883:
Xie, Xiaohui; Lu, Jun; Kulbokas, E. J.; Golub, Todd R.; Mootha, Vamsi; Lindblad-Toh, Kerstin; Lander, Eric S.; Kellis, Manolis (2005-02-27).
2658:
1304:"Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers"
570:
519:
118:
1364:
Gjoneska, Elizabeta; Pfenning, Andreas R.; Mathys, Hansruedi; Quon, Gerald; Kundaje, Anshul; Tsai, Li-Huei; Kellis, Manolis (2015).
2638:
457:
To date, his lab has developed specific domain expertise in obesity, diabetes, Alzheimer's disease, schizophrenia, heart disease,
1721:
Kellis, Manolis; Wold, Barbara; Snyder, Michael P.; Bernstein, Bradley E.; Kundaje, Anshul; Marinov, Georgi K.; Ward, Lucas D.;
425:
resolution, studying inter-individual variation associated with genetic differences and disease phenotypes, including the first
358:
Kellis started comparing the genomes of yeast species as an MIT graduate student. As part of this work, which was published in
258:
250:
88:
2608:
2412:
385:
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Kellis was born in Greece, moved with his family to France when he was 12, and came to the U.S. in 1993. He obtained his
2633:
36:
1185:
462:
2437:"NSF Award Search: Award#0644282 - CAREER: Comparative Genomics and Biological Signal Discovery in the Human Genome"
2613:
2663:
334:
2129:
Xiong, Xushen; Hou, Lei; Park, Yongjin P.; Molinie, Benoit; Gregory, Richard I.; Kellis, Manolis (August 2021).
2508:
1596:
1859:
458:
301:
293:
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1885:"Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals"
565:
446:
347:
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In addition to his research, Kellis co-taught for several years MIT's required undergraduate introductory
404:, and others at MIT used epigenomic markings in human and mouse brains to study the mechanisms leading to
422:
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523:
124:
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2225:
2557:
1159:"Kellis to lead MIT team in new phase of GTEx project to elucidate basis of disease predisposition"
477:
courses 6.006: Introduction to
Algorithms and 6.046: Design and Analysis of Algorithms with Profs.
265:. He is the head of the Computational Biology Group at MIT and is a Principal Investigator in the
1432:
2618:
1485:"NIH Grant, Network-based prediction and validation of causal schizophrenia genes and variants"
561:
502:
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148:
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frontiers of research in order to become active practitioners of the field. He started 6.881:
2265:
2212:
493:
246:
1950:"Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes"
1366:"Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease"
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2079:
2018:
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1036:
969:
880:
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Kellis is also a Principal Investigator of the enhancing GTEx (eGTEx) consortium, studying
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158:
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8:
2007:"Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures"
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1090:"Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE"
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1697:"NIH-supported researchers map epigenome of more than 100 tissue and cell types"
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Proceedings of the National Academy of Sciences of the United States of America
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Recipients of the Presidential Early Career Award for Scientists and Engineers
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2293:"6.006: Introduction to Algorithms - Massachusetts Institute of Technology"
2172:
2131:"Genetic drivers of m6A methylation in human brain, lung, heart and muscle"
2107:
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1991:
1934:
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1025:"Mapping and analysis of chromatin state dynamics in nine human cell types"
1009:
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802:
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The Kellis Lab has profiled a large number of human post-mortem brains at
2242:"Single-cell profiling of the human primary motor cortex in ALS and FTLD"
1722:
1504:
869:"A high-resolution map of human evolutionary constraint using 29 mammals"
486:
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Regulatory Genomics and Epigenomics of Complex Disease - Manolis Kellis
1965:
622:
478:
615:
Computational comparative genomics : genes, regulation, evolution
724:
474:
174:
1319:
2389:"Computational Personal Genomics: Making Sense of Complete Genomes"
273:
2460:
2185:
675:
499:
Computational Personal Genomics: Making sense of complete genomes
350:(ENCODE) project, the Genotype Tissue-Expression (GTEx) project.
310:
262:
175:
Computational Comparative Genomics: Genes, Regulation, Evolution.
1244:"FTO Obesity Variant Circuitry and Adipocyte Browning in Humans"
1301:
1022:
306:
168:
99:
77:
73:
2581:
Wellcome Genome Campus Courses and Conferences (2016-02-25),
2413:"Aaronson, Kellis recipients of PECASE 2010 Award | MIT EECS"
1791:
841:"Researchers generate a reference map of the human epigenome"
817:"Researchers generate a reference map of the human epigenome"
2238:
1087:
862:
860:
516:
Presidential Early Career Award for Scientists and Engineers
113:
Presidential Early Career Award for Scientists and Engineers
750:
2004:
1363:
449:
changes of RNA transcripts across multiple human tissues.
427:
single-cell transcriptomic analysis of Alzheimer's disease
1720:
1483:
Manolis, Kellis; Mark, Daly; Kevin, Eggan; Alkes, Price.
1241:
955:
857:
322:
217:
1947:
866:
753:"Integrative analysis of 111 reference human epigenomes"
1727:"Defining functional DNA elements in the human genome"
1590:"Manolis Kellis MIT Center for Genome Research Resume"
1186:"Identifying the gene switch that turns fat cells bad"
958:"Defining functional DNA elements in the human genome"
933:"Analysis of 29 mammals reveals genomic 'dark matter'"
556:
Regulatory Genomics and Epigenomics of Complex Disease
530:
Medal for Outstanding Achievements in Science by the
39:(ASHG) meeting in Orlando Florida on October 19, 2017
2509:"MIT School of Engineering | » Teaching Awards"
564:
Advanced Courses and Scientific Conferences team at
432:
2128:
503:
Neurogenomics: Computational Molecular Neuroscience
413:to change even before neural changes are observed.
2069:
1882:
2531:
1482:
2600:
1433:"Epigenomics of Alzheimer's disease progression"
329:, founding director of the Broad Institute, and
267:Computer Science and Artificial Intelligence Lab
2558:"Decoding A Genomic Revolution | TEDxCambridge"
962:Proceedings of the National Academy of Sciences
2644:Massachusetts Institute of Technology faculty
376:fundamental processes and disease in humans.
316:
2649:Massachusetts Institute of Technology alumni
612:
571:Manolis Kellis Reddit Ask Me Anything (AMA)
251:Massachusetts Institute of Technology (MIT)
599:
29:
2162:
2046:
1981:
1924:
1768:
1750:
1538:
1405:
1335:
1275:
1216:"A Fat-Burning Gene May Help Weight Loss"
1129:
1064:
999:
981:
908:
792:
272:Kellis is known for his contributions to
2534:"Innovator Under 35: Manolis Kellis, 29"
1457:"Manolis Kellis – Cure Alzheimer's Fund"
680:MIT Computational Biology Group Lab Head
520:National Science Foundation CAREER award
416:
353:
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1618:
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1584:
1582:
1500:
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340:
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1849:
1847:
1725:; Crawford, Gregory E. (2014-04-29).
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606:
89:Massachusetts Institute of Technology
2629:Greek emigrants to the United States
2485:"Kellis Wins Niki Award | MIT CSAIL"
1857:
746:
744:
725:"Roadmap Epigenomics Project - Home"
588:
586:
538:
509:
452:
1701:National Institutes of Health (NIH)
1648:"Kanellakis Fellowships | MIT EECS"
1613:
1579:
1495:
1473:
445:changes of regulatory elements and
13:
1844:
1785:
1422:
1352:
1292:
1232:
1203:
1175:
1146:
698:
37:American Society of Human Genetics
16:Greek-born computational biologist
14:
2680:
1563:"Getting to the root of genetics"
741:
676:"MIT Computational Biology Group"
583:
535:research in comparative genomics
433:Genotype-Tissue Expression (GTEx)
2659:21st-century American biologists
1673:"Manolis Kellis - PubMed - NCBI"
636:
2639:Human Genome Project scientists
2574:
2550:
2525:
2501:
2477:
2453:
2429:
2405:
2381:
2357:
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2309:
2285:
2232:
2179:
2122:
2063:
1998:
1941:
1876:
1714:
1689:
1664:
1640:
1555:
1449:
1248:New England Journal of Medicine
1081:
1016:
949:
925:
489:, Srinivas Devadas and others.
386:New England Journal of Medicine
335:Xerox Palo Alto Research Center
325:from MIT, where he worked with
241:; born 1977) is a professor of
833:
809:
717:
692:
668:
644:
370:
1:
1860:"Annotating the book of life"
613:Kamvysselis, Manolis (2003).
577:
546:Decoding A Genomic Revolution
652:"Manolis Kellis | MIT CSAIL"
566:Churchill College, Cambridge
348:Encyclopedia of DNA Elements
7:
2609:Greek expatriates in France
468:
10:
2685:
2461:"Sloan Foundation Fellows"
2147:10.1038/s41588-021-00890-3
729:www.roadmapepigenomics.org
379:
317:Education and early career
2634:Greek computer scientists
2317:"6.046/18.410 Class Home"
2250:10.1101/2021.07.07.451374
2197:10.1101/2021.06.23.449672
1523:10.1038/s41525-017-0040-5
524:Sloan Research Fellowship
408:’s disease, published in
238:
212:
208:
185:
167:
141:
134:
125:Sloan Research Fellowship
105:
95:
84:
55:
44:
28:
21:
2341:"6.047/6.878 Class Home"
1624:"All Awards | MIT CSAIL"
595:publications indexed by
2614:Genetic epidemiologists
2532:MIT Technology Review.
2365:"Computational Biology"
1752:10.1073/pnas.1318948111
1114:10.1126/science.1198374
983:10.1073/pnas.1318948111
514:Kellis received the US
429:(Nature, 2019), single
2664:Scientists from Athens
2273:Cite journal requires
2220:Cite journal requires
562:Wellcome Genome Campus
492:He is also teaching a
149:Computational genomics
35:Manolis Kellis at the
2538:MIT Technology Review
2297:courses.csail.mit.edu
2244:: 2021.07.07.451374.
2191:: 2021.06.23.449672.
1864:MIT Technology Review
1461:Cure Alzheimer's Fund
1260:10.1056/nejmoa1502214
494:computational biology
247:Computational Biology
1677:www.ncbi.nlm.nih.gov
1511:npj Genomic Medicine
701:"People | MIT CSAIL"
417:Single-cell Genomics
354:Comparative genomics
298:single-cell genomics
253:and a member of the
159:Comparative Genomics
2092:10.1038/nature02424
2084:2004Natur.428..617K
2031:10.1038/nature06340
2023:2007Natur.450..219S
1909:10.1038/nature03441
1901:2005Natur.434..338X
1814:10.1038/nature01644
1806:2003Natur.423..241K
1743:2014PNAS..111.6131K
1390:10.1038/nature14252
1382:2015Natur.518..365G
1106:2010Sci...330.1787R
1100:(6012): 1787–1797.
1049:10.1038/nature09906
1041:2011Natur.473...43E
974:2014PNAS..111.6131K
893:10.1038/nature10530
885:2011Natur.478..476.
777:10.1038/nature14248
769:2015Natur.518..317.
617:(PhD thesis). MIT.
501:, and 6.883/9.S99:
396:Alzheimer's disease
341:Research and career
239:Μανώλης Καμβυσέλλης
56:Μανώλης Καμβυσέλλης
49:Manolis Kamvysellis
2393:MIT OpenCourseWare
2369:MIT OpenCourseWare
1966:10.1101/gr.6679507
1858:Schaffer, Amanda.
2489:www.csail.mit.edu
2078:(6983): 617–624.
2017:(7167): 219–232.
1960:(12): 1823–1836.
1895:(7031): 338–345.
1800:(6937): 241–254.
1737:(17): 6131–6138.
1376:(7539): 365–369.
968:(17): 6131–6138.
879:(7370): 476–482.
763:(7539): 317–330.
705:www.csail.mit.edu
699:Kellis, Manolis.
656:www.csail.mit.edu
539:Media appearances
510:Awards and honors
453:Disease Mechanism
447:epitranscriptomic
294:disease mechanism
228:
227:
136:Scientific career
2676:
2654:Biotechnologists
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2141:(8): 1156–1165.
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1595:. Archived from
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483:Erik Demaine
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2441:www.nsf.gov
1671:pubmeddev.
623:1721.1/7999
487:Piotr Indyk
423:single-cell
371:Epigenomics
327:Eric Lander
282:epigenomics
195:Eric Lander
154:Epigenomics
2603:Categories
2590:2018-07-19
2567:2018-07-19
2543:2018-07-19
2518:2018-07-19
2494:2018-07-19
2470:2018-07-19
2446:2018-07-19
2422:2018-07-19
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2374:2018-07-19
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2302:2018-07-19
1869:2018-07-19
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1606:2018-07-19
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1466:2018-07-19
1442:2018-07-19
1225:2018-07-19
1196:2018-07-19
1168:2018-07-19
942:2018-07-21
850:2018-07-19
826:2018-07-18
734:2018-07-24
710:2018-07-19
685:2018-07-19
661:2018-07-19
578:References
479:Ron Rivest
443:epigenomic
63:1977-03-13
2465:sloan.org
2258:235779849
2205:235655818
2155:1546-1718
2100:0028-0836
2039:0028-0836
1974:1088-9051
1917:0028-0836
1822:0028-0836
1761:0027-8424
1531:2056-7944
1398:0028-0836
1328:1061-4036
1268:0028-4793
1122:0036-8075
1057:0028-0836
992:0027-8424
901:0028-0836
785:0028-0836
475:algorithm
406:Alzheimer
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2108:15004568
2057:17994088
1992:17989253
1935:15735639
1830:12748633
1779:24753594
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1437:MIT News
1416:25693568
1346:25751624
1286:26287746
1163:MIT News
1140:21177974
1075:21441907
1010:24753594
937:MIT News
919:21993624
845:MIT News
821:MIT News
803:25693563
631:53277177
469:Teaching
400:Kellis,
274:genomics
2164:9112289
2116:4422074
2080:Bibcode
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2019:Bibcode
1983:2099591
1926:2923337
1897:Bibcode
1838:1530261
1802:Bibcode
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1739:Bibcode
1540:5765157
1407:4530583
1378:Bibcode
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1066:3088773
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910:3207357
881:Bibcode
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765:Bibcode
380:Obesity
311:GENCODE
263:Harvard
249:at the
218:compbio
213:Website
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360:Nature
307:ENCODE
296:, and
180:(2003)
178:
169:Thesis
142:Fields
127:(2008)
121:(2007)
115:(2010)
106:Awards
100:ENCODE
78:Greece
74:Athens
2254:S2CID
2201:S2CID
2112:S2CID
1834:S2CID
1600:(PDF)
1593:(PDF)
235:Greek
91:(PhD)
52:Greek
2279:help
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627:OCLC
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