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could mimic the effects of the drugs. Reflecting in 1995 about that time, Hughes said: "From my personal point of view, I think that the reason I got interested in searching for an endogenous opioid-like substance is that I had been previously involved during my PhD student work in looking at
343:. After testing many samples in Kosterlitz's assays, the two scientists were able to isolate and identify two peptides, met- and leu-enkephalin, as naturally occurring molecules from the brain, that have activity resembling
666:
Hughes, J.; Smith, T.W.; Kosterlitiz, H.W.; Fothergill, Linda A.; Morgan, B.A.; Morris, H.R. (18 December 1975). "Identification of two related pentapeptides from the brain with potent opiate agonist activity".
347:. Hughes and Kosterlitz first announced their findings at a scientific conference in May 1974, and published the structures of the two enkephalins in 1975. In 1978, they shared the Lasker award with
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non-adrenergic, noncholinergic innervation of various blood vessels and that's what my PhD thesis was eventually written on." He would bicycle daily to a
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Brain-Robbers: How
Alcohol, Cocaine, Nicotine, and Opiates Have Changed Human History
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Anatomy of a
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281:. Later, he became Director of the Parke-Davis Neuroscience Centre at the
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While working with
Kosterlitz at Aberdeen, Hughes helped discover the
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Recipients of the Albert Lasker Award for Basic
Medical Research
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532:"Hans W. Kosterlitz, 93; Found Clues in Brain on Pain Control"
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Cholecystokinin/dopamine interactions in the rat basal ganglia
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326:. Hughes sought to determine whether molecules present in
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Tansey, E.M.; Christie, D.A., eds. (7 November 1995).
261:. He took a position as lecturer in Pharmacology at
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312:for responses to opiate drugs, using pieces of
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195:Albert Lasker Award for Basic Medical Research
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372:(PhD thesis). University of Cambridge.
233:. He received BSc and PhD degrees from
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760:Academics of Imperial College London
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205:. This discovery demonstrated that
189:(born 6 January 1942) is a British
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530:Freeman, Karen (8 November 1996).
470:"Opiate receptors and enkephalins"
253:, where he studied the effects of
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209:drugs exert their effects on the
588:Frankenburg, Frances R. (2014).
745:Alumni of King's College London
265:, where he had a laboratory in
229:Hughes was born and grew up in
556:. In Pasternak, Gavril (ed.).
1:
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770:Fellows of the Royal Society
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560:. Humana Press. p. 4.
552:Snyder, Solomon H. (1988).
308:. Kosterlitz had developed
291:Fellow of the Royal Society
87:Fellow of the Royal Society
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621:. Wellcome Trust. p.
245:After his PhD, Hughes did
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594:. Praeger. p. 213.
445:"John Hughes: Biography"
368:Marshall, Fiona (1990).
297:Discovery of enkephalins
213:by mimicking endogenous
740:English pharmacologists
735:English neuroscientists
506:. Skyhorse Publishing.
500:Goldberg, Jeff (2013).
420:"Professor John Hughes"
400:, A & C Black, 2017
283:University of Cambridge
279:Imperial College London
273:. He went on to become
131:University of Cambridge
127:Imperial College London
119:Yale School of Medicine
750:Scientists from London
178:/professor-john-hughes
16:British neuroscientist
618:3. Endogenous Opiates
247:postdoctoral research
235:King's College London
197:for the discovery of
61:King's College London
558:The Opiate Receptors
193:who shared the 1978
681:1975Natur.258..577H
472:. Lasker Foundation
447:. The Royal Society
263:Aberdeen University
251:Yale Medical School
241:Career and research
123:Aberdeen University
554:"Initial Findings"
536:The New York Times
394:Hughes, Prof. John
378:uk.bl.ethos.386170
675:(5536): 577–579.
349:Solomon H. Snyder
267:Marischal College
215:neurotransmitters
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147:Doctoral students
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105:Neuroscience
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82:Lasker award
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649:|work=
255:angiotensin
211:human brain
187:John Hughes
72:enkephalins
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719:Categories
451:23 January
355:References
314:guinea pig
303:enkephalin
37:1942-01-06
651:ignored (
641:cite book
476:8 January
426:8 January
317:intestine
225:Education
57:Education
337:extracts
306:peptides
168:.wolfson
697:1207728
677:Bibcode
345:opioids
341:acetone
257:on the
176:/people
161:Website
137:Patrons
52:British
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669:Nature
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339:using
328:brains
310:assays
275:Reader
217:, the
207:opiate
101:Fields
89:(1993)
84:(1978)
78:Awards
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701:S2CID
374:EThOS
321:mouse
259:heart
693:PMID
653:help
627:ISBN
596:ISBN
562:ISBN
508:ISBN
478:2017
453:2017
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319:and
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31:Born
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