124:
746:
723:
55:
1124:(TdP), a heart rhythm disturbance that is sometimes fatal. Despite the observed change in the QT interval, the risk of TdP from escitalopram appears to be quite low, and it is similar to other antidepressants that are not known to affect QT interval. A 2013 review discusses several reasons to be optimistic about the safety of escitalopram. It references a crossover study in which 113 subjects were each given four different treatments in randomized order: placebo, 10 mg/day escitalopram, 30 mg/day escitalopram, or 400 mg/day
1549:, a known strong CYP2D6 inhibitor, has been found to significantly increase citalopram plasma concentration and systemic exposure (peak levels increased by 30%, total exposure increased by 40%); as of April 2018 the interaction with escitalopram had not been studied, but some monographs warned of the potential interaction. Citalopram did not affect the pharmacokinetics of bupropion or its metabolites in the study.
46:
10702:
1967:
1417:(by <0.4 points). Antidepressant exposure is not associated with an increased risk of spontaneous abortion. There is a tentative association of SSRI use during pregnancy with heart problems in the baby. The advantages of their use during pregnancy may thus not outweigh the possible negative effects on the baby.
2033:
In 2004, separate civil suits alleging illegal marketing of citalopram and escitalopram for use by children and teenagers by Forest were initiated by two whistleblowers: a physician named Joseph
Piacentile and a Forest salesman named Christopher Gobble. In February 2009, the suits were joined. Eleven
1149:
had less risk), and it ranked 5th of 9 by TdP incidence in patients ages 18-64. Antidepressants as a class had a relatively low risk of TdP, and most patients on an antidepressant who experienced TdP were also taking another drug that prolongs QT interval. Specifically, 80% of the escitalopram users
1033:
Controversy existed regarding the effectiveness of escitalopram compared with its predecessor, citalopram. The importance of this issue followed from the greater cost of escitalopram relative to the generic mixture of isomers of citalopram, prior to the expiration of the escitalopram patent in 2012,
1140:
More data about the cardiac risk from escitalopram can be found in a large observational study from Sweden that took note of all the medications used by all the patients presenting with TdP, and found the incidence of TdP in escitalopram users to be only 0.7 cases of TdP for every 100,000 patients
1109:
among the adults treated with escitalopram for psychiatric indications. The authors of a related study note the general problem with statistical approaches: due to the rarity of suicidal events in clinical trials, it is hard to draw firm conclusions with a sample smaller than two million patients.
1379:(44%), muscle tension (44%), chills (44%), confusion or trouble concentrating (40%), amnesia (28%), and crying (28%). Very slow tapering was recommended. There have been spontaneous reports of discontinuation of Lexapro and other SSRIs and SNRIs, especially when abrupt, leading to dysphoric mood,
2024:
In 2006, Forest
Laboratories was granted an 828-day (2 years and 3 months) extension on its US patent for escitalopram. This pushed the patent expiration date from 7 December 2009, to 14 September 2011. Together with the 6-month pediatric exclusivity, the final expiration date was 14 March 2012.
1132:
known to cause QTc prolongation). At 10 mg/day, escitalopram increased the QTc interval by 4.5 milliseconds (ms). At 30 mg/day, the QTc increased by 10.7 ms. A QTc increase of less than 60 ms is not likely to confer significant risk. The 30 mg/day escitalopram dose induced significantly less QTc
2041:
to physicians to induce them to prescribe
Lexapro to children; and conducted so-called "seeding studies" that were, in reality, marketing efforts to promote the drug's use by doctors. Forest denied the allegations but ultimately agreed to settle with the plaintiffs for over $ 313 million.
3044:
Bech P, Lönn SL, Overø KF (February 2010). "Relapse prevention and residual symptoms: a closer analysis of placebo-controlled continuation studies with escitalopram in major depressive disorder, generalized anxiety disorder, social anxiety disorder, and obsessive-compulsive disorder".
1441:
may occur in some cases. Therapeutic blood levels of escitalopram are usually in the range of 20–80 μg/L but may reach 80–200 μg/L in the elderly, patients with hepatic dysfunction, those who are poor CYP2C19 metabolizers or following acute overdose. Monitoring of the drug in
1399:
Some people experience persistent sexual side effects when taking SSRIs or after discontinuing them. Symptoms of medication-induced sexual dysfunction from antidepressants include difficulty with orgasm, erection, or ejaculation. Other symptoms may be genital anesthesia,
1141:
who took the drug (ages 18-64), and only 4.1 cases of TdP for every 100,000 elderly patients who took the drug (ages 65 and up). Of the 9 antidepressants that were used by patients with TdP, escitalopram ranked 7th by TdP incidence in elderly patients (only
2953:
Sicras-Mainar A, Navarro-Artieda R, Blanca-Tamayo M, Gimeno-de la Fuente V, Salvatella-Pasant J (December 2010). "Comparison of escitalopram vs. citalopram and venlafaxine in the treatment of major depression in Spain: clinical and economic consequences".
1986:. Its development was initiated in 1997, and the resulting new drug application was submitted to the US FDA in March 2001. The short time (3.5 years) it took to develop escitalopram can be attributed to the previous experience of Lundbeck and Forest with
1038:. Accordingly, this issue has been examined in at least 10 different systematic reviews and meta analyses. As of 2012, reviews had concluded (with caveats in some cases) that escitalopram is modestly superior to citalopram in efficacy and tolerability.
4249:
Noehr-Jensen L, Zwisler ST, Larsen F, Sindrup SH, Damkier P, Brosen K (December 2009). "Escitalopram is a weak inhibitor of the CYP2D6-catalyzed O-demethylation of (+)-tramadol but does not reduce the hypoalgesic effect in experimental pain".
3775:"Unequal Sized Pupils Due to Escitalopram; Adverse Events to Dietary Supplements Causing Emergency Department Visits; Compulsive Masturbation Due to Pramipexole; Metformin-Induced Lactic Acidosis Masquerading As an Acute Myocardial Infarction"
2763:"Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects"
4099:
Ross LE, Grigoriadis S, Mamisashvili L, Vonderporten EH, Roerecke M, Rehm J, et al. (April 2013). "Selected pregnancy and delivery outcomes after exposure to antidepressant medication: a systematic review and meta-analysis".
2003:
Escitalopram is sold under many brand names worldwide such as
Cipralex, Lexapro, Lexam, Mozarin, Aciprex, Depralin, Ecytara, Elicea, Gatosil, Nexpram, Nexito, Nescital, Szetalo, Stalopam, Pramatis, Betesda, Scippa and Rexipra.
125:
1029:
Escitalopram is among the most effective and well-tolerated antidepressants for the short-term (acute) treatment of major depressive disorder in adults. It is also the safest one to give to children and adolescents.
937:
Common side effects include trouble sleeping, nausea, sexual problems, and feeling tired. More serious side effects may include suicidal thoughts in people up to the age of 24 years. It is unclear if use during
3857:
Shen J, Hossain N, Streiner DL, Ravindran AV, Wang X, Deb P, et al. (November 2011). "Excessive daytime sleepiness and fatigue in depressed patients and therapeutic response of a sedating antidepressant".
2234:
1626:
Escitalopram can also prolong the QT interval, and hence it is not recommended in patients that are concurrently on other medications that also have the ability to prolong the QT interval. These drugs include
1177:
should be corrected before starting treatment. In
December 2011, the UK implemented new restrictions on the maximum daily doses at 20 mg for adults and 10 mg for those older than 65 years or with
1412:
Antidepressant exposure (including escitalopram) is associated with shorter duration of pregnancy (by three days), increased risk of preterm delivery (by 55%), lower birth weight (by 75 g), and lower
1342:
The most common effect is fatigue or somnolence, particularly in older adults, although patients with pre-existing daytime sleepiness and fatigue may experience paradoxical improvement of these symptoms.
2012:
The FDA issued the approval of escitalopram for major depression in August 2002, and for generalized anxiety disorder in
December 2003. In May 2006, the FDA approved a generic version of escitalopram by
4702:
Mansari ME, Wiborg O, Mnie-Filali O, Benturquia N, Sánchez C, Haddjeri N (February 2007). "Allosteric modulation of the effect of escitalopram, paroxetine and fluoxetine: in-vitro and in-vivo studies".
1906:
on the transporter, thereby decreasing its own disassociation rate. Escitalopram binds to this allosteric site at a greater affinity than other SSRIs. The clinical relevance of this action is unknown.
4667:
Zhong H, Haddjeri N, Sánchez C (January 2012). "Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter--a review of current understanding of its mechanism of action".
3344:
Khan A, Schwartz K (2007). "Suicide risk and symptom reduction in patients assigned to placebo in duloxetine and escitalopram clinical trials: analysis of the FDA summary basis of approval reports".
5059:
7397:
3963:
Yasui-Furukori N, Hashimoto K, Tsuchimine S, Tomita T, Sugawara N, Ishioka M, et al. (June 2016). "Characteristics of
Escitalopram Discontinuation Syndrome: A Preliminary Study".
3486:
332:
2133:
3473:
In summary, the effects of citalopram and other antidepressants in therapeutic doses on QTc are not likely to be of clinical relevance unless other known risk factors are present.
2683:"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis"
4146:
Gentile S (1 July 2015). "Early pregnancy exposure to selective serotonin reuptake inhibitors, risks of major structural malformations, and hypothesized teratogenic mechanisms".
2037:
The suits alleged that Forest illegally engaged in off-label promotion of
Lexapro for use in children; hid the results of a study showing lack of effectiveness in children; paid
3718:
4353:
3751:
9260:
10286:
9946:
9255:
2171:
2018:
2223:
3487:"FDA Drug Safety Communication: Revised recommendations for Celexa (citalopram hydrobromide) related to a potential risk of abnormal heart rhythms with high doses"
2918:
Favré P (February 2012). "" [Clinical efficacy and achievement of a complete remission in depression: Increasing interest in treatment with escitalopram].
1158:
with 52,750 users, and sotalol had a TdP incidence of 81.1 cases and 41.2 cases of TdP per 100,000 users in the ≥65 and 18-64 year-old demographics, respectively.
2166:[Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).
7089:
5337:
2446:
9315:
7432:
287:
4903:
4837:
3564:"Citalopram and escitalopram: QT interval prolongation—new maximum daily dose restrictions (including in elderly patients), contraindications, and warnings"
9457:
5051:
3567:
2573:
1120:
prolongation, which is a measure of how rapidly the heart muscle repolarizes after each heartbeat. Prolongation of the QT interval is a risk factor for
815:
3239:"Antidepressants and Suicidality in Adults: Statistical Evaluation. (Presentation at Psychopharmacologic Drugs Advisory Committee; December 13, 2006)"
345:
3319:
3282:
2812:"Effectiveness and cost-effectiveness of antidepressants in primary care: a multiple treatment comparison meta-analysis and cost-effectiveness model"
1931:
penetrability. In a preclinical study in rats combining escitalopram with a P-glycoprotein inhibitor, its antidepressant-like effects were enhanced.
3688:
10762:
5223:
3248:
4437:
Brunton L, Chabner B, Knollman B. Goodman and Gilman's The
Pharmacological Basis of Therapeutics, Twelfth Edition. McGraw Hill Professional; 2010.
8512:
6925:
5304:
3571:
1105:. An analysis conducted by the FDA found a statistically insignificant 1.5 to 2.4-fold (depending on the statistical technique used) increase of
10545:
4189:
Haupt D (October 1996). "Determination of citalopram enantiomers in human plasma by liquid chromatographic separation on a Chiral-AGP column".
10099:
10054:
9666:
2473:
The selection and use of essential medicines 2023: web annex A: World Health
Organization model list of essential medicines: 23rd list (2023)
1404:, decreased libido, vaginal lubrication issues, and nipple insensitivity in women. Rates are unknown, and there is no established treatment.
1182:. The US Food and Drug Administration and Health Canada did not similarly order restrictions on escitalopram dosage, only on its predecessor
172:
2603:
10650:
10565:
9991:
9377:
8919:
8914:
8195:
8190:
8009:
6988:
6596:
6581:
6511:
6119:
5370:
2655:
844:
10655:
10580:
10530:
10201:
9936:
9914:
9889:
9879:
9724:
7082:
4812:
1898:(NET), making the side-effect profile relatively mild in comparison to less-selective SSRIs. In addition to its antagonist action at the
10276:
10226:
10168:
10163:
8698:
2386:
10490:
10485:
10480:
10475:
10256:
10069:
9839:
9295:
9036:
7427:
7422:
5121:
3710:
1545:
resulted in increased exposure to the escitalopram enantiomer, owing to the strong inhibition of CYP2C19 and CYP2D6 by these agents.
5005:
4345:
3893:
Rosekind MR, Gregory KB, Mallis MM (December 2006). "Alertness management in aviation operations: enhancing performance and sleep".
1533:, a CYP2C19 inhibitor. The authors of this study suggested that this increase is unlikely to be of clinical concern. Combination of
10505:
10500:
10495:
10386:
10381:
10261:
9966:
9864:
9859:
9844:
9779:
9774:
9521:
9420:
3740:
2074:
872:
InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1
10470:
9961:
9450:
6953:
6566:
5165:
4952:
4929:
4876:
4526:
Chae YJ, Jeon JH, Lee HJ, Kim IB, Choi JS, Sung KW, et al. (January 2014). "Escitalopram block of hERG potassium channels".
1903:
6934:
3212:
2633:
2196:
10455:
10450:
7417:
7075:
4006:
2416:
1083:
915:
279:
5052:"Drug Maker Forest Pleads Guilty; To Pay More Than $ 313 Million to Resolve Criminal Charges and False Claims Act Allegations"
6869:
6232:
6176:
4384:
2504:
1391:(psychomotor restlessness), mania, worsening of depression, and suicidal ideation can emerge when the dose is adjusted down.
1001:
in adults. In European countries and the United Kingdom, it is approved for depression and anxiety disorders; these include:
978:
5029:
4455:
1970:
Cipralex brand escitalopram 10 mg package and tablet sheet. It is a reference escitalopram formulation, and was produced by
2163:
9404:
6918:
5403:
4976:
1580:
4743:"P-glycoprotein inhibition increases the brain distribution and antidepressant-like activity of escitalopram in rodents"
4379:. Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Kong, Sydney, Tokyo: Lippincott Williams & Wilkins.
1879:, which is associated with an improvement in passive stress tolerance, and delayed downstream increase in expression of
889:
223:
10742:
9443:
7770:
5271:
4233:
2159:
1451:
2438:
10722:
4048:
2276:
Pastoor D, Gobburu J (January 2014). "Clinical pharmacology review of escitalopram for the treatment of depression".
1880:
1838:
1346:
Escitalopram has not been shown to affect serial reaction time, logical reasoning, serial subtraction, multitask, or
1165:
or known pre-existing QT interval prolongation, or in combination with other medicines that prolong the QT interval.
864:
10737:
9219:
6886:
6193:
9546:
4899:
4845:
2021:
decided in favor of Lundbeck regarding a patent infringement dispute and ruled the patent on escitalopram valid.
516:
317:
204:
9586:
9424:
6911:
6306:
4007:"Lexapro (Escitalopram Oxalate) Drug Information: Warnings and Precautions - Prescribing Information at RxList"
2014:
1871:
of the neurotransmitter into the presynaptic neuron. Over time, this leads to a downregulation of pre-synaptic
1502:
by 40% and total exposure by 100%. Likewise, it has been found to increase peak levels of the CYP2D6 substrate
1161:
Drugs that prolong the QT interval, such as escitalopram, should be used with caution in those with congenital
3928:
Prakash O, Dhar V (June 2008). "Emergence of electric shock-like sensations on escitalopram discontinuation".
8480:
5114:
2551:
2164:"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"
1359:
1150:
who experienced TdP were taking at least one other drug known to cause TdP. For comparison, the most popular
1010:
2999:"Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis"
10680:
9400:
7117:
7098:
6641:
3243:
2167:
1047:
998:
981:. In 2022, it was the fifteenth most commonly prescribed medication in the United States, with more than 30
923:
741:
622:
3513:"Drug use and torsades de pointes cardiac arrhythmias in Sweden: a nationwide register-based cohort study"
3308:
3271:
10371:
8764:
8040:
6626:
5776:
5709:
3596:
van Gorp F, Whyte IM, Isbister GK (September 2009). "Clinical and ECG effects of escitalopram overdose".
3170:
Clayton A, Keller A, McGarvey EL (March 2006). "Burden of phase-specific sexual dysfunction with SSRIs".
2105:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
1799:
1786:
1573:
1387:, insomnia, and hypomania. Other symptoms such as panic attacks, hostility, aggressiveness, impulsivity,
702:
3822:
Lenze EJ (20 May 2009). "Escitalopram Treatment of Generalized Anxiety Disorder in Older Adults—Reply".
3238:
10747:
10732:
10692:
7759:
7271:
5539:
5447:
1895:
1887:
1727:
1425:
Excessive doses of escitalopram usually cause relatively minor untoward effects, such as agitation and
1365:
691:
3563:
3082:"Efficacy of escitalopram in the treatment of social anxiety disorder: A meta-analysis versus placebo"
2034:
states and the District of Columbia filed notices of intent to intervene as plaintiffs in the action.
10316:
10024:
7003:
6611:
6225:
5551:
4064:
Bala A, Nguyen HM, Hellstrom WJ (January 2018). "Post-SSRI Sexual Dysfunction: A Literature Review".
2869:
Cipriani A, Purgato M, Furukawa TA, Trespidi C, Imperadore G, Signoretti A, et al. (July 2012).
2468:
2104:
994:
919:
4295:"The effect of cimetidine or omeprazole on the pharmacokinetics of escitalopram in healthy subjects"
10727:
5107:
1636:
1174:
718:
3680:
10767:
10752:
9237:
6874:
6181:
2595:
2051:
1928:
1055:
1006:
260:
138:
5030:"Forest Laboratories, Inc. Provides Statement in Response to Complaint Filed by U.S. Government"
4040:
2681:
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. (April 2018).
1129:
10525:
10326:
10034:
9576:
9416:
9412:
8819:
8095:
7525:
7478:
7039:
6016:
5487:
3379:
Castro VM, Clements CC, Murphy SN, Gainer VS, Fava M, Weilburg JB, et al. (January 2013).
1051:
425:
4805:
2134:"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017"
671:
9931:
8537:
8469:
7943:
7245:
7029:
5457:
1891:
1825:
1717:
1620:
1313:
1067:
826:
471:
2952:
2734:(Plain English summary). National Institute for Health and Care Research. 1 September 2020.
2382:
611:
546:
182:
9754:
9408:
9280:
8809:
8353:
8085:
7515:
7494:
7106:
6538:
6218:
6136:
6051:
2823:
2761:
Solmi M, Fornaro M, Ostinelli EG, Zangani C, Croatto G, Monaco F, et al. (June 2020).
2730:"Psychiatric drugs given to children and adolescents have been ranked in order of safety".
1812:
1737:
1656:
1652:
1616:
1553:
631:
478:
5086:
5015:
3381:"QT interval and antidepressant use: a cross sectional study of electronic health records"
8:
9094:
8939:
8804:
8532:
8389:
8215:
8080:
7735:
7510:
5962:
5902:
4957:
3711:"Cipralex 5, 10 and 20 mg film-coated tablets - Summary of Product Characteristics (SPC)"
3511:
Danielsson B, Collin J, Nyman A, Bergendal A, Borg N, State M, et al. (March 2020).
1983:
1495:
1121:
1091:
927:
537:
466:
267:
4620:"How do antidepressants work? New perspectives for refining future treatment approaches"
3080:
Baldwin DS, Asakura S, Koyama T, Hayano T, Hagino A, Reines E, et al. (June 2016).
2827:
2662:(Plain English summary). National Institute for Health and Care Research. 3 April 2018.
2626:"Cipralex 10 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc)"
2082:
1050:, with relapse on escitalopram at 20% rather than placebo at 50%, which translates to a
745:
722:
10589:
9616:
9590:
9469:
9179:
7205:
5153:
5149:
5091:
5037:
5010:
4767:
4742:
4644:
4619:
4595:
4570:
4551:
4503:
4479:"A comparative review of escitalopram, paroxetine, and sertraline: Are they all alike?"
4478:
4319:
4294:
4275:
4171:
4125:
3988:
3799:
3774:
3657:
3632:
3537:
3512:
3459:
3434:
3405:
3380:
3147:
3122:
3026:
2979:
2895:
2870:
2846:
2811:
2787:
2762:
2743:
2707:
2682:
2038:
1612:
1604:
1569:
1384:
1275:
234:
4962:
4925:
4868:
4635:
4202:
3609:
3272:"Clinical Review: Relationship Between Antidepressant Drugs and Suicidality in Adults"
3014:
2698:
1529:
Exposure to escitalopram is increased moderately, by about 50%, when it is taken with
54:
10757:
9170:
7908:
7615:
7190:
6380:
6153:
6055:
5574:
4772:
4720:
4684:
4649:
4600:
4543:
4508:
4417:
4380:
4324:
4310:
4267:
4229:
4206:
4163:
4117:
4081:
4044:
3980:
3945:
3910:
3875:
3839:
3804:
3681:"Lexapro (escitalopram) dosing, indications, interactions, adverse effects, and more"
3662:
3613:
3542:
3464:
3410:
3361:
3205:
3187:
3152:
3103:
3062:
3018:
2971:
2935:
2900:
2851:
2792:
2747:
2712:
2625:
2347:
2343:
2293:
1596:
1102:
369:
357:
196:
4555:
4279:
4175:
4113:
4010:
3992:
3098:
3081:
3030:
2983:
2526:
2408:
10158:
10124:
9621:
9601:
9477:
9275:
9130:
8502:
7898:
7595:
7535:
7352:
7266:
6345:
6126:
6069:
6005:
5852:
4762:
4754:
4712:
4676:
4639:
4631:
4590:
4582:
4535:
4498:
4490:
4409:
4314:
4306:
4259:
4198:
4155:
4129:
4109:
4073:
3972:
3937:
3902:
3867:
3831:
3794:
3786:
3652:
3644:
3605:
3532:
3524:
3454:
3446:
3400:
3392:
3353:
3316:
Overview for 13 December Meeting of Pharmacological Drugs Advisory Committee (PDAC)
3279:
Overview for 13 December Meeting of Pharmacological Drugs Advisory Committee (PDAC)
3179:
3142:
3138:
3134:
3093:
3054:
3010:
2963:
2927:
2890:
2886:
2882:
2841:
2831:
2782:
2774:
2735:
2702:
2694:
2663:
2563:
2476:
2339:
2285:
1899:
1663:
1561:
1179:
1162:
1086:, has been shown to affect sexual function, causing side effects such as decreased
1002:
758:
571:
407:
300:
72:
4741:
O'Brien FE, O'Connor RM, Clarke G, Dinan TG, Griffin BT, Cryan JF (October 2013).
4159:
2998:
2496:
10706:
10415:
10196:
10104:
9704:
9694:
9245:
9120:
9062:
9050:
8718:
8357:
7989:
7923:
7337:
7225:
7200:
6744:
6736:
6726:
6523:
6254:
6065:
6059:
5872:
5246:
4494:
4447:
3976:
3941:
2967:
2836:
2568:
2289:
1872:
1760:
1747:
1671:
1628:
1347:
1170:
435:
415:
7067:
6245:
5134:
3528:
2997:
Slee A, Nazareth I, Bondaronek P, Liu Y, Cheng Z, Freemantle N (February 2019).
2931:
1470:, and hence may increase plasma levels of a number of CYP2D6 substrates such as
10555:
10550:
9996:
9764:
9714:
9596:
9466:
9074:
9058:
9054:
8980:
8703:
8369:
8361:
7974:
7740:
7463:
7215:
6945:
6880:
6716:
6558:
6472:
6320:
6294:
6187:
5629:
5338:
5236:
5130:
4869:"FDA OKs Generic Depression Drug – Generic Version of Lexapro Gets Green Light"
4077:
1916:
1592:
1151:
1014:
911:
4987:
4716:
4680:
4539:
3871:
3357:
3309:"Statistical Evaluation of Suicidality in Adults Treated with Antidepressants"
3183:
10716:
10440:
10216:
9986:
9739:
9699:
9330:
9114:
9110:
9080:
9046:
9020:
9010:
8965:
8929:
8789:
8733:
8572:
8434:
8414:
8397:
8375:
8296:
8291:
8241:
8205:
8065:
8004:
7730:
7250:
7235:
7195:
6825:
6710:
6687:
6505:
6467:
6446:
6077:
6024:
5812:
5684:
5659:
5654:
5594:
5569:
4586:
3843:
1640:
1632:
1600:
1447:
1371:
such as "electric shock" sensations, colloquially called "brain shivers" or "
1146:
970:
943:
734:
382:
37:
9435:
7347:
7342:
4228:(8th ed.). Foster City, Ca: Biomedical Publications. pp. 552–553.
3058:
10630:
10615:
10595:
10570:
10006:
9899:
9749:
9641:
9556:
9531:
9265:
9160:
9150:
8975:
8970:
8814:
8784:
8672:
8420:
8332:
8301:
8256:
8251:
8246:
8090:
8060:
7948:
7857:
7817:
7720:
7640:
7530:
7520:
7332:
7327:
7312:
7307:
7286:
7043:
7012:
6795:
6785:
6775:
6754:
6677:
6620:
6462:
6284:
6122:
6110:
6020:
5927:
5857:
5847:
5699:
5689:
5589:
5584:
5507:
5502:
5482:
5467:
5421:
5147:
4776:
4724:
4688:
4653:
4604:
4547:
4512:
4421:
4328:
4271:
4167:
4121:
4085:
3984:
3949:
3914:
3906:
3879:
3808:
3666:
3617:
3546:
3468:
3414:
3365:
3191:
3156:
3107:
3066:
3022:
2975:
2939:
2904:
2855:
2796:
2716:
2351:
2297:
2197:"Lexapro- escitalopram tablet, film coated; Lexapro- escitalopram solution"
1471:
1455:
1443:
1380:
1301:
1249:
1125:
1071:
1035:
831:
295:
8625:
Selective serotonin reuptake inhibitors and serotonin receptor modulators:
4263:
4210:
3835:
1486:, etc. As escitalopram is only a weak inhibitor of CYP2D6, analgesia from
10665:
10645:
10635:
10600:
10560:
10460:
10391:
10356:
10351:
10341:
10173:
10109:
10064:
10059:
9894:
9854:
9769:
9759:
9734:
9651:
9606:
9571:
9335:
9325:
9270:
9241:
9191:
9135:
9088:
9070:
9005:
8985:
8934:
8924:
8899:
8859:
8854:
8799:
8769:
8748:
8738:
8728:
8688:
8627:
8607:
8597:
8577:
8557:
8517:
8507:
8454:
8383:
8365:
8337:
8322:
8281:
8261:
8210:
8200:
8175:
8135:
8130:
8075:
8045:
8024:
8014:
7999:
7964:
7928:
7893:
7822:
7812:
7802:
7797:
7745:
7725:
7715:
7690:
7670:
7600:
7575:
7550:
7545:
7540:
7505:
7500:
7458:
7453:
7402:
7210:
7055:
7033:
6997:
6974:
6805:
6790:
6780:
6758:
6700:
6657:
6635:
6456:
6442:
6390:
6365:
6360:
6040:
5937:
5802:
5737:
5732:
5722:
5679:
5664:
5649:
5639:
5609:
5599:
5472:
5442:
5437:
5383:
5360:
5355:
5327:
5284:
5261:
5251:
5193:
5099:
4758:
4413:
4039:(5th ed.). Arlington, VA: American Psychiatric Publishing. pp.
2667:
1648:
1542:
1499:
1475:
1426:
1414:
1142:
1117:
1106:
1018:
931:
190:
6903:
3790:
2739:
2656:"The most effective antidepressants for adults revealed in major review"
2481:
591:
10660:
10605:
10540:
10535:
10435:
10366:
10346:
10311:
10306:
10301:
10271:
10221:
10178:
10143:
10094:
10089:
10049:
10016:
10011:
10001:
9981:
9976:
9909:
9884:
9709:
9656:
9646:
9611:
9580:
9566:
9541:
9536:
9516:
9511:
9384:
9340:
9305:
9232:
9195:
9155:
9125:
9102:
9066:
9015:
9000:
8884:
8869:
8839:
8829:
8824:
8779:
8774:
8713:
8708:
8693:
8667:
8637:
8632:
8617:
8612:
8587:
8582:
8552:
8547:
8527:
8522:
8446:
8425:
8408:
8403:
8286:
8276:
8160:
8145:
8115:
8105:
8100:
8055:
8050:
7984:
7979:
7938:
7918:
7903:
7878:
7862:
7837:
7832:
7710:
7700:
7685:
7630:
7620:
7610:
7590:
7580:
7565:
7560:
7483:
7473:
7468:
7281:
7174:
7169:
7051:
7047:
6982:
6978:
6970:
6962:
6820:
6748:
6695:
6672:
6667:
6650:
6590:
6548:
6533:
6415:
6370:
6355:
6335:
6330:
6325:
6241:
6158:
6144:
6130:
6036:
6032:
6028:
5982:
5952:
5947:
5942:
5922:
5892:
5882:
5842:
5827:
5807:
5694:
5674:
5644:
5624:
5604:
5564:
5512:
5497:
5492:
5452:
5416:
5388:
5317:
5294:
5289:
5241:
5213:
5208:
5203:
5188:
5178:
4098:
3962:
3648:
3450:
1987:
1951:
1944:
1679:
1659:
1644:
1538:
1534:
1530:
1503:
1454:. Chiral techniques are available to distinguish escitalopram from its
1434:
1430:
1372:
1364:
Escitalopram discontinuation, particularly abruptly, may cause certain
1243:
1235:
1230:
1183:
1134:
1113:
1095:
974:
955:
951:
834:
791:
602:
460:
274:
28:
20:
2778:
10640:
10625:
10610:
10585:
10515:
10430:
10410:
10361:
10296:
10291:
10206:
10074:
9971:
9951:
9924:
9904:
9829:
9729:
9719:
9689:
9631:
9626:
9506:
9501:
9372:
9320:
9290:
9285:
9205:
9187:
9183:
9140:
9098:
9041:
8990:
8909:
8879:
8743:
8662:
8652:
8647:
8642:
8567:
8562:
8442:
8438:
8327:
8317:
8266:
8185:
8155:
8019:
7969:
7888:
7883:
7852:
7847:
7807:
7705:
7695:
7660:
7585:
7555:
7488:
7448:
7412:
7317:
7302:
7276:
7240:
7230:
7159:
7154:
7149:
7144:
6855:
6850:
6845:
6835:
6815:
6740:
6662:
6605:
6495:
6477:
6452:
6425:
6410:
6405:
6400:
6395:
6340:
6274:
6210:
6046:
5932:
5867:
5862:
5837:
5832:
5822:
5817:
5727:
5669:
5634:
5614:
5579:
5535:
5393:
5350:
5322:
5256:
5198:
3396:
1924:
1920:
1864:
1683:
1675:
1608:
1584:
1579:
Escitalopram, similarly to other SSRIs, may increase bleed risk with
1565:
1546:
1401:
1388:
1376:
1318:
1283:
1270:
1265:
939:
557:
491:
176:
6989:
6597:
6582:
5371:
5224:
1883:, which may contribute to a reduction in negative affective biases.
1863:
Escitalopram increases intrasynaptic levels of the neurotransmitter
10620:
10575:
10465:
10425:
10420:
10336:
10183:
10044:
9676:
9671:
9661:
9359:
9310:
9300:
9199:
9145:
9106:
9084:
8874:
8864:
8657:
8450:
8393:
8379:
8150:
8140:
7842:
7827:
7792:
7650:
7645:
7635:
7605:
7407:
7164:
6830:
6810:
6730:
6543:
6487:
6430:
6420:
6385:
6375:
6350:
6279:
5797:
5753:
5477:
5462:
5305:
3123:"Selective serotonin reuptake inhibitors for premenstrual syndrome"
1979:
1971:
1948:
1868:
1588:
1487:
1479:
1257:
959:
651:
582:
218:
4740:
4701:
1506:
by 50% and overall exposure by 82%. Escitalopram does not inhibit
814:
10266:
10246:
10241:
10148:
10084:
9849:
9824:
9819:
9814:
9809:
9804:
9799:
9744:
9561:
9526:
9165:
8995:
8948:
8944:
8894:
8889:
8844:
8834:
8794:
8723:
8602:
8271:
8224:
8220:
8170:
8165:
8120:
8110:
8070:
7994:
7913:
7675:
7665:
7655:
7625:
7570:
7392:
7387:
7382:
7377:
7372:
7367:
7362:
7322:
7220:
7139:
6800:
6437:
6266:
5619:
3120:
2439:"Protocol for switching patients from escitalopram to citalopram"
1572:. As an SSRI, escitalopram should not be given concurrently with
1557:
1519:
1483:
1368:
1307:
1295:
1155:
1133:
prolongation than a therapeutically equivalent 60 mg/day dose of
444:
24:
4926:"Forest Laboratories Receives Patent Term Extension for Lexapro"
4248:
4034:
2527:"Escitalopram Drug Usage Statistics, United States, 2013 - 2022"
10251:
10236:
10153:
10114:
10079:
9956:
9874:
9869:
9834:
9794:
9496:
9175:
8904:
8849:
8592:
8430:
8180:
8125:
7933:
7680:
7357:
6954:
6840:
6567:
5343:
Tooltip Noradrenergic and specific serotonergic antidepressants
5166:
2871:"Citalopram versus other anti-depressive agents for depression"
2868:
2680:
2330:
Rao N (2007). "The clinical pharmacokinetics of escitalopram".
1886:
Of the SSRIs currently available, escitalopram has the highest
1773:
1523:
1515:
1511:
1507:
1467:
1438:
1324:
1289:
1225:
1087:
682:
528:)-1--1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
452:
448:
45:
973:
in 2002. Escitalopram is rarely replaced by twice the dose of
10211:
10138:
9789:
9491:
5534:
4340:
4338:
1021:. In Australia it is approved for major depressive disorder.
805:
662:
500:
496:
440:
4400:
Boyer EW, Shannon M (March 2005). "The serotonin syndrome".
3856:
2760:
1568:, tramadol, and other serotonergic drugs due to the risk of
1490:
may not be affected. Escitalopram (at the maximum dose of 20
707:
10188:
9681:
9249:
5404:
1966:
1848:
1116:
and escitalopram are associated with a mild dose-dependent
1101:
There is also evidence that SSRIs may cause an increase in
642:
99:
84:
78:
7771:
5272:
4335:
3378:
3121:
Marjoribanks J, Brown J, O'Brien PM, Wyatt K (June 2013).
3079:
2809:
6519:
2996:
2467:
2112:
1375:" by those affected. Frequent symptoms in one study were
1166:
977:; escitalopram is safer and more effective. It is on the
111:
93:
9220:
2221:
9547:
4571:"Serotonin and brain function: a tale of two receptors"
4476:
3741:"Escitalopram-Lupin Tablets (LUPIN AUSTRALIA PTY. LTD)"
979:
World Health Organization's List of Essential Medicines
8762:
Serotonin–norepinephrine–dopamine reuptake inhibitors:
8038:
Serotonin–norepinephrine–dopamine reuptake inhibitors:
6307:
1066:
Escitalopram is effective in reducing the symptoms of
10690:
10189:
9682:
8481:
6935:
4928:(Press release). PRNewswire-FirstCall. 2 March 2006.
4292:
4191:
Journal of Chromatography. B, Biomedical Applications
4037:
Diagnostic and Statistical Manual of Mental Disorders
3892:
3595:
3169:
2385:. The American Society of Health-System Pharmacists.
1552:
Escitalopram should be taken with caution when using
102:
81:
75:
7118:
6994:
Tooltip Serotonin-norepinephrine reuptake inhibitors
6642:
6602:
Tooltip Serotonin antagonist and reuptake inhibitors
6587:
Tooltip Serotonin-norepinephrine reuptake inhibitors
5376:
Tooltip Serotonin antagonist and reuptake inhibitors
5229:
Tooltip Serotonin–norepinephrine reuptake inhibitors
4705:
The International Journal of Neuropsychopharmacology
4666:
3630:
2271:
2269:
2267:
2265:
2263:
2261:
2259:
2257:
2255:
1169:
measurements should be considered for patients with
1054:
of 3.33. Escitalopram appears effective in treating
108:
105:
96:
90:
10372:
6627:
5710:
5310:
Tooltip Norepinephrine–dopamine reuptake inhibitors
4984:
US District Court for the district of Massachusetts
4953:"Forest Laboratories: A Tale of Two Whistleblowers"
4293:Malling D, Poulsen MN, Søgaard B (September 2005).
4063:
3568:
Medicines and Healthcare products Regulatory Agency
3478:
2191:
2189:
2097:
2028:
993:Escitalopram has FDA approval for the treatment of
918:(SSRI) class. Escitalopram is mainly used to treat
114:
87:
7760:
5087:"A Peek at How Forest Laboratories Pushed Lexapro"
4568:
4148:Expert Opinion on Drug Metabolism & Toxicology
2596:"Lundbeck's Cipralex gets EU ok for OCD treatment"
1978:Escitalopram was developed in cooperation between
10317:
10025:
7097:
7004:
6612:
5552:
4977:"United States of America v. Forest Laboratories"
4477:Sanchez C, Reines EH, Montgomery SA (July 2014).
4346:"Drug interactions between bupropion and Lexapro"
2252:
1194:Very common effects (>10% incidence) include:
1046:Escitalopram appears to be effective in treating
969:Escitalopram was approved for medical use in the
10714:
5775:
4617:
2231:List of nationally authorised medicinal products
2186:
1137:, which increased the QTc interval by 18.5 ms.
570:
167:(+)-Citalopram; (+)-Citalopram; LU-26054; MLD-55
6959:Tooltip Selective serotonin reuptake inhibitors
6572:Tooltip Selective serotonin reuptake inhibitors
6112:
5171:Tooltip Selective serotonin reuptake inhibitors
4226:Disposition of toxic drugs and chemicals in man
3591:
3589:
3306:
545:
10327:
10035:
4528:Naunyn-Schmiedeberg's Archives of Pharmacology
4525:
3631:Hasnain M, Howland RH, Vieweg WV (July 2013).
3506:
3504:
2275:
9465:
9451:
8686:Serotonin–norepinephrine reuptake inhibitors:
8470:
7962:Serotonin–norepinephrine reuptake inhibitors:
7790:Selective norepinephrine reuptake inhibitors:
7083:
6919:
6226:
5115:
4569:Carhart-Harris RL, Nutt DJ (September 2017).
3750:. Lupin Australia Pty Ltd. 21 December 2011.
3043:
2810:Ramsberg J, Asseburg C, Henriksson M (2012).
2409:"Escitalopram (Lexapro) Use During Pregnancy"
7876:Norepinephrine–dopamine reuptake inhibitors:
7107:
4783:
4470:
4399:
4286:
3921:
3785:(5). Thomas Land Publishers, Inc.: 358–361.
3586:
3372:
3343:
3337:
3163:
3114:
3073:
3037:
2911:
1919:and hence P-glycoprotein inhibitors such as
1615:due to escitalopram's inhibitory effects on
222:
6512:
6146:
5963:
5903:
5409:Tooltip Serotonin modulator and stimulators
4217:
4182:
4141:
4139:
3927:
3895:Aviation, Space, and Environmental Medicine
3501:
3428:
3426:
3424:
3236:
3127:The Cochrane Database of Systematic Reviews
2875:The Cochrane Database of Systematic Reviews
2222:Human Medicines Division (September 2022).
1353:
1214:
399:In general: ℞ (Prescription only)
9458:
9444:
7776:Tooltip Norepinephrine reuptake inhibitors
7090:
7076:
6926:
6912:
6233:
6219:
5277:Tooltip Norepinephrine reuptake inhibitors
5129:
5122:
5108:
5003:
4830:
4794:(6 ed.). Elsevier. 2016. p. 383.
4618:Harmer CJ, Duman RS, Cowen PJ (May 2017).
3307:Levenson M, Holland C (17 November 2006).
3269:
2377:
2375:
2373:
2371:
2369:
2367:
2365:
2363:
2361:
2069:
2067:
1383:, agitation, anxiety, headache, lethargy,
1219:Common effects (1–10% incidence) include:
744:
721:
610:
6933:
4766:
4643:
4594:
4502:
4483:International Clinical Psychopharmacology
4318:
4223:
4035:American Psychiatric Association (2013).
3798:
3656:
3536:
3458:
3404:
3146:
3097:
2894:
2845:
2835:
2786:
2706:
2567:
2480:
2325:
2323:
2321:
2319:
2317:
2315:
2313:
2311:
2309:
2307:
630:
9225:Tooltip Vesicular monoamine transporters
8500:Selective serotonin reuptake inhibitors:
6004:
4299:British Journal of Clinical Pharmacology
4136:
3637:Journal of Psychiatry & Neuroscience
3439:Journal of Psychiatry & Neuroscience
3421:
1965:
10763:Selective serotonin reuptake inhibitors
9587:Dehydroepiandrosterone sulfate (DHEA-S)
9552:Tooltip Calcitonin gene-related peptide
6255:
4950:
4897:
4838:"Mozarin, zamienniki i podobne rodukty"
4145:
3772:
3270:Stone MB, Jones ML (17 November 2006).
2461:
2431:
2358:
2064:
1902:of SERT, escitalopram also binds to an
1070:, whether taken continuously or in the
717:
590:
195:
10715:
6312:Tooltip positive allosteric modulators
6295:
6240:
5084:
4818:from the original on 27 September 2007
4736:
4734:
4252:Clinical Pharmacology and Therapeutics
4030:
4028:
3930:Journal of Clinical Psychopharmacology
3484:
3435:"Antidepressants and QTc prolongation"
3251:from the original on 27 September 2007
2304:
2158:
2138:Therapeutic Goods Administration (TGA)
1993:
1694:
1337:
1189:
916:selective serotonin reuptake inhibitor
852:Fc1ccc(cc1)3(OCc2cc(C#N)ccc23)CCCN(C)C
735:
391:
363:
280:Selective serotonin reuptake inhibitor
9439:
8486:Tooltip Serotonin reuptake inhibitors
7071:
6907:
6214:
6099:
6003:
5774:
5533:
5146:
5103:
5062:from the original on 30 November 2020
5004:Meier B, Carey B (25 February 2009).
4433:
4431:
4374:
4188:
3821:
3558:
3556:
2917:
2475:. Geneva: World Health Organization.
2419:from the original on 31 December 2017
2389:from the original on 29 December 2017
2240:from the original on 6 September 2022
1954:, which is responsible for its name:
1394:
690:
670:
376:
213:
181:
7123:Tooltip Dopamine reuptake inhibitors
6647:Tooltip Monoamine oxidase inhibitors
4906:from the original on 30 October 2021
4377:2006 Lippincott's Nursing Drug Guide
3721:from the original on 3 December 2013
3691:from the original on 2 December 2013
3300:
3263:
2956:Current Medical Research and Opinion
1041:
299:
10377:Tooltip 3,4,5-Trimethoxyamphetamine
6632:Tooltip Tetracyclic antidepressants
5715:Tooltip Tetracyclic antidepressants
4879:from the original on 5 January 2007
4866:
4731:
4402:The New England Journal of Medicine
4025:
3733:
3703:
3673:
3633:"Escitalopram and QTc prolongation"
3432:
3230:
3218:from the original on 15 August 2018
2507:from the original on 30 August 2024
2449:from the original on 10 August 2020
2329:
2224:"Active substance(s): escitalopram"
1910:
1494:mg/day) has been found to increase
650:
561:
23:version of the medication. For its
13:
8820:Didesmethylsibutramine (BTS-54505)
8096:Didesmethylsibutramine (BTS-54505)
7765:Tooltip Norepinephrine transporter
7526:Didesmethylsibutramine (BTS-54505)
5036:. 26 February 2009. Archived from
4932:from the original on 15 April 2009
4519:
4458:from the original on 9 August 2022
4428:
4356:from the original on 23 April 2018
3815:
3754:from the original on 29 March 2019
3553:
3325:from the original on 16 March 2007
3288:from the original on 16 March 2007
3047:The Journal of Clinical Psychiatry
2174:from the original on 3 August 2023
1990:, which has similar pharmacology.
14:
10779:
10551:Chlorphenamine (chlorpheniramine)
10322:Tooltip N,N-Diisopropyltryptamine
10030:Tooltip N,N-Diisopropyltryptamine
7338:Etybenzatropine (ethybenztropine)
7009:Tooltip Tricyclic antidepressants
6617:Tooltip Tricyclic antidepressants
6100:
5557:Tooltip Tricyclic antidepressants
5078:
4900:"US court upholds Lexapro patent"
4806:"2000 Annual Report. p 28 and 33"
3610:10.1016/j.annemergmed.2009.04.016
3574:from the original on 6 March 2013
3206:"Lexapro prescribing information"
2636:from the original on 10 June 2020
2606:from the original on 10 June 2020
2576:from the original on 10 June 2020
1881:brain-derived neurotrophic factor
326:
245:
10700:
8810:Desmethylsibutramine (BTS-54354)
8086:Desmethylsibutramine (BTS-54354)
7516:Desmethylsibutramine (BTS-54354)
5006:"Drug Maker Is Accused of Fraud"
4311:10.1111/j.1365-2125.2005.02423.x
3510:
3086:European Neuropsychopharmacology
2344:10.2165/00003088-200746040-00002
2029:Allegations of illegal marketing
1670:(except palonosetron), and some
1450:is generally accomplished using
778:
775:
769:
71:
53:
44:
9421:Monoamine metabolism modulators
5044:
5022:
4997:
4969:
4944:
4918:
4891:
4860:
4798:
4790:"Citalopram and escitalopram".
4695:
4660:
4611:
4562:
4440:
4393:
4368:
4242:
4114:10.1001/jamapsychiatry.2013.684
4092:
4057:
3999:
3956:
3886:
3850:
3766:
3715:electronic Medicines Compendium
3624:
3198:
3099:10.1016/j.euroneuro.2016.02.013
2990:
2946:
2862:
2803:
2754:
2723:
2674:
2648:
2618:
2588:
2544:
2519:
2489:
2401:
2019:U.S. District Court of Delaware
2007:
1915:Escitalopram is a substrate of
1689:
1461:
1254:Decreased or increased appetite
1077:
997:in adolescents and adults, and
988:
930:, available commercially as an
877:Key:WSEQXVZVJXJVFP-FQEVSTJZSA-N
10332:Tooltip N,N-Dipropyltryptamine
10040:Tooltip N,N-Dipropyltryptamine
9740:Pentoxyverine (carbetapentane)
4951:Frankel A (27 February 2009).
4792:Meyler's Side Effects of Drugs
3860:Journal of Affective Disorders
3172:Journal of Affective Disorders
3139:10.1002/14651858.CD001396.pub3
2887:10.1002/14651858.CD006534.pub2
2278:Expert Opin Drug Metab Toxicol
2215:
2152:
2126:
1998:
946:is safe. Escitalopram is the (
784:
763:
352:
339:
1:
10681:Receptor/signaling modulators
9577:Dehydroepiandrosterone (DHEA)
9401:Receptor/signaling modulators
8475:Tooltip Serotonin transporter
7099:Monoamine reuptake inhibitors
5085:Harris G (1 September 2009).
4636:10.1016/S2215-0366(17)30015-9
4575:Journal of Psychopharmacology
4203:10.1016/s0378-4347(96)00177-6
4160:10.1517/17425255.2015.1063614
3346:Annals of Clinical Psychiatry
3015:10.1016/S0140-6736(18)31793-8
2699:10.1016/S0140-6736(17)32802-7
2233:. European Medicines Agency.
2057:
1947:(left-handed version) of the
1466:Escitalopram weakly inhibits
1360:SSRI discontinuation syndrome
1024:
1011:obsessive–compulsive disorder
902:, sold under the brand names
348:(Other controlled substances)
8315:Tetracyclic antidepressants:
7112:Tooltip Dopamine transporter
5777:Monoamine oxidase inhibitors
4495:10.1097/YIC.0000000000000023
3977:10.1097/WNF.0000000000000139
3942:10.1097/JCP.0b013e3181727534
3598:Annals of Emergency Medicine
3244:Food and Drug Administration
2968:10.1185/03007995.2010.529430
2837:10.1371/journal.pone.0042003
2569:10.18773/austprescr.2003.107
2290:10.1517/17425255.2014.863873
1934:
1407:
1204:Ejaculation disorder (9–14%)
1048:generalized anxiety disorder
1003:generalized anxiety disorder
999:generalized anxiety disorder
924:generalized anxiety disorder
7:
9765:Racemethorphan (methorphan)
8765:3,3-Diphenylcyclobutanamine
8041:3,3-Diphenylcyclobutanamine
5971:Tooltip Monoamine oxidase B
5911:Tooltip Monoamine oxidase A
5540:tetracyclic antidepressants
4898:Laforte ME (14 July 2006).
4844:(in Polish). Archived from
3529:10.1136/bmjopen-2019-034560
3485:US FDA (15 December 2017).
2932:10.1016/j.encep.2011.11.003
2045:
1420:
10:
10784:
9405:Monoamine releasing agents
8963:Tricyclic antidepressants:
8239:Tricyclic antidepressants:
7308:Benzatropine (benztropine)
5448:Dextromethorphan/bupropion
4078:10.1016/j.sxmr.2017.07.002
3965:Clinical Neuropharmacology
2485:. WHO/MHP/HPS/EML/2023.02.
2170:(published 4 April 2023).
1961:
1896:norepinephrine transporter
1357:
1298:(muscular aches and pains)
753:Chemical and physical data
499:(major; 8–10% unchanged),
19:This article is about the
18:
10743:Drugs developed by AbbVie
10674:
10400:
10123:
9476:
9393:
9349:
9218:
9029:
8958:
8757:
8681:
8495:
8468:
8346:
8310:
8234:
8033:
7957:
7871:
7785:
7758:
7441:
7295:
7259:
7183:
7132:
7105:
7022:
6944:
6864:
6768:
6709:
6686:
6557:
6504:
6486:
6293:
6253:
6171:
6106:
6095:
6012:
5999:
5961:
5901:
5787:
5783:
5770:
5746:
5708:
5550:
5546:
5529:
5430:
5402:
5369:
5336:
5303:
5270:
5222:
5164:
5160:
5142:
4717:10.1017/S1461145705006462
4681:10.1007/s00213-011-2463-5
4540:10.1007/s00210-013-0911-y
3872:10.1016/j.jad.2011.04.047
3358:10.1080/10401230601163550
3184:10.1016/j.jad.2005.12.007
2469:World Health Organization
1637:tricyclic antidepressants
1304:(abnormal skin sensation)
1082:Escitalopram, like other
995:major depressive disorder
920:major depressive disorder
885:
860:
840:
825:
803:
790:
757:
752:
733:
701:
681:
661:
641:
621:
601:
581:
556:
536:
512:
507:
490:
477:
459:
434:
424:
414:
406:
316:
311:
286:
273:
259:
233:
203:
189:
171:
147:
143:Cipralex, Lexapro, others
137:
66:
61:
52:
43:
10723:4-Fluorophenyl compounds
9642:Fabomotizole (afobazole)
9617:Dimethyltryptamine (DMT)
8689:Atomoxetine (tomoxetine)
7965:Atomoxetine (tomoxetine)
6154:Rubidium chloride (RbCl)
4587:10.1177/0269881117725915
3318:. FDA. pp. 75–140.
1498:of the CYP2D6 substrate
1354:Discontinuation symptoms
1215:Common (1–10% incidence)
1175:electrolyte disturbances
1061:
1034:which led to charges of
10738:Dimethylamino compounds
10606:Mepyramine (pyrilamine)
10287:3-Methoxydextrallorphan
9947:3-Methoxydextrallorphan
9770:Racemorphan (morphanol)
9067:mepyramine (pyrilamine)
7040:Atypical antipsychotics
6264:Tooltip 5-HT1A receptor
6017:Atypical antipsychotics
4747:Neuropsychopharmacology
4066:Sexual Medicine Reviews
3773:Mancano MA (May 2016).
3281:. FDA. pp. 11–74.
3237:Levenson M, Holland C.
3059:10.4088/JCP.08m04749blu
2168:Diário Oficial da União
2079:Drugs.com International
2052:List of antidepressants
1894:(SERT) compared to the
1452:chromatographic methods
1056:social anxiety disorder
1007:social anxiety disorder
985:million prescriptions.
10661:Tiospirone (BMY-13859)
10601:Gevotroline (WY-47384)
10526:18-Methoxycoronaridine
10513:Allosteric modulators:
10272:Panamesine (EMD-57455)
10222:Siramesine (Lu 28-179)
10159:Ditolylguanidine (DTG)
9922:Allosteric modulators:
9885:Panamesine (EMD-57455)
9830:BMY-14802 (BMS-181100)
9622:Ditolylguanidine (DTG)
9602:Dextromethorphan (DXM)
9341:Vanoxerine (GBR-12909)
9188:pethidine (meperidine)
8443:pethidine (meperidine)
7231:Pethidine (meperidine)
7030:Typical antipsychotics
6304:Tooltip GABAA receptor
4624:The Lancet. Psychiatry
3907:10.3357/asem.1879.2006
3748:TGA eBusiness Services
2552:"Escitalopram oxalate"
1975:
1621:serotonin transporters
1562:dextromethorphan (DXM)
1286:(erectile dysfunction)
1154:drug in the study was
1052:number needed to treat
910:, among others, is an
9932:Methylphenylpiracetam
9507:Alazocine (SKF-10047)
9425:Monoamine neurotoxins
8991:Dosulepin (dothiepin)
8538:Didesmethylcitalopram
8267:Dosulepin (dothiepin)
7944:Serdexmethylphenidate
7246:Serdexmethylphenidate
5058:. 15 September 2010.
4264:10.1038/clpt.2009.154
3836:10.1001/jama.2009.652
3433:Lam RW (March 2013).
2556:Australian Prescriber
2497:"The Top 300 of 2022"
1969:
1939:Escitalopram is the (
1892:serotonin transporter
1068:premenstrual syndrome
472:Didesmethylcitalopram
9755:Pregnenolone sulfate
9567:Cutamesine (SA-4503)
9316:Methoxytetrabenazine
9281:Dihydrotetrabenazine
9095:Arylcyclohexylamines
8390:Arylcyclohexylamines
7541:Dizocilpine (MK-801)
7495:Chaenomeles speciosa
7196:Benocyclidine (BTCP)
6539:Gabapentin enacarbil
6138:Hypericum perforatum
6006:Adjunctive therapies
5034:Forest press-release
5018:on 11 November 2020.
4965:on 28 February 2009.
4759:10.1038/npp.2013.120
4414:10.1056/NEJMra041867
2693:(10128): 1357–1366.
2668:10.3310/signal-00580
2630:www.medicines.org.uk
2017:. In July 2006, the
1668:receptor antagonists
1617:platelet aggregation
9905:Rimcazole (BW-234U)
8940:Threohydrobupropion
8805:Desmethylsertraline
8533:Desmethylcitalopram
8216:Threohydrobupropion
8081:Desmethylsertraline
7736:Threohydrobupropion
7511:Desmethylsertraline
5154:receptor modulators
5150:reuptake inhibitors
5040:on 24 January 2013.
4958:The American Lawyer
3791:10.1310/hpj5105-358
2828:2012PLoSO...742003R
2740:10.3310/alert_40795
2602:. 12 January 2007.
1994:Society and culture
1984:Forest Laboratories
1929:blood brain barrier
1701:
1695:Mechanism of action
1605:omega-3 fatty acids
1338:Psychomotor effects
1190:Very common effects
1122:torsades de pointes
1092:delayed ejaculation
958:(which exists as a
467:Desmethylcitalopram
372:(Prescription only)
335:(Prescription only)
40:
16:SSRI antidepressant
9662:Igmesine (JO-1784)
9591:prasterone sulfate
9180:dextropropoxyphene
7206:Dexmethylphenidate
6891:Never to phase III
6198:Never to phase III
5092:The New York Times
5011:The New York Times
4848:on 17 October 2020
4811:. Lundbeck. 2000.
4669:Psychopharmacology
4224:Baselt RC (2008).
3717:. 2 October 2013.
3649:10.1503/jpn.130055
3451:10.1503/jpn.120256
3009:(10173): 768–777.
2332:Clin Pharmacokinet
2203:. 17 November 2023
1976:
1699:
1597:antiplatelet drugs
1570:serotonin syndrome
1395:Sexual dysfunction
1385:emotional lability
1350:task performance.
1321:(nasal congestion)
1276:Excessive sweating
1207:Somnolence (4–13%)
962:), hence the name
934:salt exclusively.
36:
10748:Enantiopure drugs
10733:CYP2D6 inhibitors
10688:
10687:
10523:Unknown/unsorted:
10284:Unknown/unsorted:
10019:
9944:Unknown/unsorted:
9607:Dextrorphan (DXO)
9433:
9432:
9428:
9214:
9213:
8489:
8464:
8463:
7909:Levophacetoperane
7779:
7754:
7753:
7616:Levophacetoperane
7191:4-Fluoropethidine
7126:
7065:
7064:
6938:pharmacotherapies
6901:
6900:
6473:Ethanol (alcohol)
6381:Ethyl loflazepate
6208:
6207:
6167:
6166:
6140:(St. John's Wort)
6091:
6090:
6056:lithium carbonate
5995:
5994:
5991:
5990:
5766:
5765:
5762:
5761:
5575:Amitriptylinoxide
5525:
5524:
5521:
5520:
4993:on 11 March 2009.
4753:(11): 2209–2219.
4408:(11): 1112–1120.
4386:978-1-58255-436-5
4154:(10): 1585–1597.
3901:(12): 1256–1265.
3779:Hospital Pharmacy
3570:. December 2011.
2962:(12): 2757–2764.
2779:10.1002/wps.20765
2562:: 146–151. 2003.
2162:(31 March 2023).
1861:
1860:
1103:suicidal ideation
1042:Anxiety disorders
897:
896:
816:Interactive image
703:CompTox Dashboard
395:
380:
367:
355:
343:
330:
249:
216:
163:-(+)-Citalopram;
10775:
10705:
10704:
10703:
10696:
10378:
10374:
10333:
10329:
10323:
10319:
10192:(midomafetamine)
10191:
10041:
10037:
10031:
10027:
10017:
9685:(midomafetamine)
9684:
9553:
9549:
9460:
9453:
9446:
9437:
9436:
9395:
9382:Antagonist-like:
9276:Deutetrabenazine
9226:
9222:
9166:MIN-117 (WF-516)
9131:Dextromethorphan
8503:6-Nitroquipazine
8493:
8492:
8487:
8483:
8478:
8476:
8472:
7899:Hydroxybupropion
7783:
7782:
7777:
7773:
7768:
7766:
7762:
7656:MIN-117 (WF-516)
7596:Hydroxybupropion
7536:Diphenylpyraline
7267:Diphenylprolinol
7130:
7129:
7124:
7120:
7115:
7113:
7109:
7092:
7085:
7078:
7069:
7068:
7010:
7006:
6995:
6991:
6960:
6956:
6937:
6928:
6921:
6914:
6905:
6904:
6737:Alpha-2 agonists
6727:Alpha-1 blockers
6720:
6648:
6644:
6633:
6629:
6618:
6614:
6603:
6599:
6588:
6584:
6573:
6569:
6527:
6521:
6518:
6346:Chlordiazepoxide
6313:
6309:
6305:
6301:
6265:
6261:
6235:
6228:
6221:
6212:
6211:
6148:
6114:
6097:
6096:
6070:triiodothyronine
6066:Thyroid hormones
6001:
6000:
5972:
5968:
5912:
5908:
5853:Phenoxypropazine
5785:
5784:
5772:
5771:
5716:
5712:
5558:
5554:
5548:
5547:
5531:
5530:
5410:
5406:
5377:
5373:
5344:
5340:
5311:
5307:
5278:
5274:
5230:
5226:
5172:
5168:
5162:
5161:
5144:
5143:
5124:
5117:
5110:
5101:
5100:
5096:
5072:
5071:
5069:
5067:
5048:
5042:
5041:
5026:
5020:
5019:
5014:. Archived from
5001:
4995:
4994:
4992:
4986:. Archived from
4981:
4973:
4967:
4966:
4961:. Archived from
4948:
4942:
4941:
4939:
4937:
4922:
4916:
4915:
4913:
4911:
4895:
4889:
4888:
4886:
4884:
4864:
4858:
4857:
4855:
4853:
4834:
4828:
4827:
4825:
4823:
4817:
4810:
4802:
4796:
4795:
4787:
4781:
4780:
4770:
4738:
4729:
4728:
4699:
4693:
4692:
4664:
4658:
4657:
4647:
4615:
4609:
4608:
4598:
4581:(9): 1091–1120.
4566:
4560:
4559:
4523:
4517:
4516:
4506:
4474:
4468:
4467:
4465:
4463:
4452:www.uptodate.com
4444:
4438:
4435:
4426:
4425:
4397:
4391:
4390:
4375:Karch A (2006).
4372:
4366:
4365:
4363:
4361:
4342:
4333:
4332:
4322:
4290:
4284:
4283:
4246:
4240:
4239:
4221:
4215:
4214:
4186:
4180:
4179:
4143:
4134:
4133:
4096:
4090:
4089:
4061:
4055:
4054:
4032:
4023:
4022:
4020:
4018:
4009:. Archived from
4003:
3997:
3996:
3960:
3954:
3953:
3925:
3919:
3918:
3890:
3884:
3883:
3866:(1–3): 421–426.
3854:
3848:
3847:
3819:
3813:
3812:
3802:
3770:
3764:
3763:
3761:
3759:
3745:
3737:
3731:
3730:
3728:
3726:
3707:
3701:
3700:
3698:
3696:
3677:
3671:
3670:
3660:
3628:
3622:
3621:
3593:
3584:
3583:
3581:
3579:
3560:
3551:
3550:
3540:
3508:
3499:
3498:
3496:
3494:
3482:
3476:
3475:
3462:
3430:
3419:
3418:
3408:
3397:10.1136/bmj.f288
3376:
3370:
3369:
3341:
3335:
3334:
3332:
3330:
3324:
3313:
3304:
3298:
3297:
3295:
3293:
3287:
3276:
3267:
3261:
3260:
3258:
3256:
3234:
3228:
3227:
3225:
3223:
3217:
3210:
3202:
3196:
3195:
3167:
3161:
3160:
3150:
3118:
3112:
3111:
3101:
3092:(6): 1062–1069.
3077:
3071:
3070:
3041:
3035:
3034:
2994:
2988:
2987:
2950:
2944:
2943:
2915:
2909:
2908:
2898:
2866:
2860:
2859:
2849:
2839:
2807:
2801:
2800:
2790:
2767:World Psychiatry
2758:
2752:
2751:
2727:
2721:
2720:
2710:
2678:
2672:
2671:
2652:
2646:
2645:
2643:
2641:
2622:
2616:
2615:
2613:
2611:
2592:
2586:
2585:
2583:
2581:
2571:
2548:
2542:
2541:
2539:
2537:
2523:
2517:
2516:
2514:
2512:
2493:
2487:
2486:
2484:
2465:
2459:
2458:
2456:
2454:
2435:
2429:
2428:
2426:
2424:
2405:
2399:
2398:
2396:
2394:
2379:
2356:
2355:
2327:
2302:
2301:
2273:
2250:
2249:
2247:
2245:
2239:
2228:
2219:
2213:
2212:
2210:
2208:
2193:
2184:
2183:
2181:
2179:
2156:
2150:
2149:
2147:
2145:
2130:
2124:
2123:
2121:
2119:
2109:nctr-crs.fda.gov
2101:
2095:
2094:
2092:
2090:
2081:. Archived from
2071:
1927:may improve its
1911:Pharmacokinetics
1900:orthosteric site
1867:by blocking the
1702:
1700:Binding profile
1698:
1493:
1210:Insomnia (7–12%)
1180:liver impairment
1163:long QT syndrome
1130:positive control
1017:with or without
984:
893:
892:
818:
798:
786:
780:
777:
771:
765:
748:
737:
726:
725:
711:
709:
694:
674:
654:
634:
614:
594:
574:
564:
563:
549:
482:
393:
390:
385:
378:
375:
365:
362:
354:
351:
341:
338:
328:
325:
303:
247:
244:
226:
215:
212:
199:
185:
132:
131:
130:
128:
121:
120:
117:
116:
113:
110:
107:
104:
101:
98:
95:
92:
89:
86:
83:
80:
77:
57:
48:
41:
39:
35:
10783:
10782:
10778:
10777:
10776:
10774:
10773:
10772:
10728:Antidepressants
10713:
10712:
10711:
10701:
10699:
10691:
10689:
10684:
10670:
10590:St. John's wort
10416:Ethylketazocine
10396:
10376:
10331:
10321:
10197:Methamphetamine
10128:
10119:
10105:Trifluoperazine
10039:
10029:
9705:Methylphenidate
9695:Methamphetamine
9551:
9481:
9472:
9464:
9434:
9429:
9389:
9367:DAT modulators:
9345:
9246:methamphetamine
9224:
9210:
9121:Cyclobenzaprine
9063:diphenhydramine
9051:brompheniramine
9025:
8954:
8753:
8719:Levomilnacipran
8677:
8485:
8477:
8474:
8460:
8358:brompheniramine
8342:
8306:
8230:
8029:
7990:Levomilnacipran
7953:
7924:Methylphenidate
7867:
7775:
7767:
7764:
7750:
7437:
7291:
7255:
7226:Methylphenidate
7201:Desoxypipradrol
7179:
7122:
7114:
7111:
7101:
7096:
7066:
7061:
7018:
7008:
6993:
6958:
6946:Antidepressants
6940:
6932:
6902:
6897:
6896:
6881:Clinical trials
6860:
6764:
6745:dexmedetomidine
6717:Antiadrenergics
6714:
6713:
6705:
6682:
6646:
6631:
6616:
6601:
6586:
6571:
6559:Antidepressants
6553:
6516:
6509:
6508:
6500:
6482:
6321:Benzodiazepines
6311:
6303:
6299:
6289:
6263:
6259:
6249:
6239:
6209:
6204:
6203:
6188:Clinical trials
6163:
6102:
6087:
6083:
6075:
6060:lithium citrate
6008:
5987:
5970:
5967:
5957:
5910:
5907:
5897:
5873:Tranylcypromine
5779:
5758:
5742:
5714:
5704:
5556:
5542:
5517:
5426:
5408:
5398:
5375:
5365:
5342:
5332:
5309:
5299:
5276:
5266:
5247:Levomilnacipran
5228:
5218:
5170:
5156:
5138:
5131:Antidepressants
5128:
5081:
5076:
5075:
5065:
5063:
5056:www.justice.gov
5050:
5049:
5045:
5028:
5027:
5023:
5002:
4998:
4990:
4979:
4975:
4974:
4970:
4949:
4945:
4935:
4933:
4924:
4923:
4919:
4909:
4907:
4896:
4892:
4882:
4880:
4865:
4861:
4851:
4849:
4836:
4835:
4831:
4821:
4819:
4815:
4808:
4804:
4803:
4799:
4789:
4788:
4784:
4739:
4732:
4700:
4696:
4665:
4661:
4616:
4612:
4567:
4563:
4524:
4520:
4475:
4471:
4461:
4459:
4446:
4445:
4441:
4436:
4429:
4398:
4394:
4387:
4373:
4369:
4359:
4357:
4344:
4343:
4336:
4291:
4287:
4247:
4243:
4236:
4222:
4218:
4187:
4183:
4144:
4137:
4102:JAMA Psychiatry
4097:
4093:
4062:
4058:
4051:
4033:
4026:
4016:
4014:
4013:on 16 June 2008
4005:
4004:
4000:
3961:
3957:
3926:
3922:
3891:
3887:
3855:
3851:
3820:
3816:
3771:
3767:
3757:
3755:
3743:
3739:
3738:
3734:
3724:
3722:
3709:
3708:
3704:
3694:
3692:
3679:
3678:
3674:
3629:
3625:
3594:
3587:
3577:
3575:
3562:
3561:
3554:
3509:
3502:
3492:
3490:
3483:
3479:
3431:
3422:
3377:
3373:
3342:
3338:
3328:
3326:
3322:
3311:
3305:
3301:
3291:
3289:
3285:
3274:
3268:
3264:
3254:
3252:
3235:
3231:
3221:
3219:
3215:
3208:
3204:
3203:
3199:
3168:
3164:
3133:(6): CD001396.
3119:
3115:
3078:
3074:
3042:
3038:
2995:
2991:
2951:
2947:
2916:
2912:
2881:(7): CD006534.
2867:
2863:
2808:
2804:
2759:
2755:
2729:
2728:
2724:
2679:
2675:
2654:
2653:
2649:
2639:
2637:
2624:
2623:
2619:
2609:
2607:
2594:
2593:
2589:
2579:
2577:
2550:
2549:
2545:
2535:
2533:
2525:
2524:
2520:
2510:
2508:
2495:
2494:
2490:
2466:
2462:
2452:
2450:
2437:
2436:
2432:
2422:
2420:
2407:
2406:
2402:
2392:
2390:
2381:
2380:
2359:
2328:
2305:
2274:
2253:
2243:
2241:
2237:
2226:
2220:
2216:
2206:
2204:
2195:
2194:
2187:
2177:
2175:
2157:
2153:
2143:
2141:
2132:
2131:
2127:
2117:
2115:
2103:
2102:
2098:
2088:
2086:
2085:on 19 June 2020
2073:
2072:
2065:
2060:
2048:
2031:
2010:
2001:
1996:
1964:
1937:
1913:
1904:allosteric site
1876:
1856:
1829:
1816:
1803:
1790:
1777:
1764:
1751:
1711:
1697:
1692:
1672:antiretrovirals
1667:
1657:fluoroquinolone
1629:antiarrhythmics
1554:St. John's wort
1491:
1464:
1423:
1410:
1397:
1362:
1356:
1348:Mackworth Clock
1340:
1335:
1217:
1192:
1171:cardiac disease
1080:
1064:
1044:
1027:
991:
982:
888:
886:
881:
878:
873:
868:
867:
856:
853:
848:
847:
821:
796:
783:
774:
768:
729:
705:
697:
677:
657:
637:
617:
597:
577:
560:
552:
532:
529:
520:
519:
480:
469:
426:Protein binding
416:Bioavailability
408:Pharmacokinetic
402:
383:
307:
262:
255:
236:
229:
126:
123:
122:
74:
70:
32:
17:
12:
11:
5:
10781:
10771:
10770:
10768:Sigma agonists
10765:
10760:
10755:
10753:Isobenzofurans
10750:
10745:
10740:
10735:
10730:
10725:
10710:
10709:
10686:
10685:
10675:
10672:
10671:
10669:
10668:
10663:
10658:
10653:
10648:
10643:
10638:
10633:
10628:
10623:
10618:
10613:
10608:
10603:
10598:
10593:
10583:
10578:
10573:
10568:
10563:
10558:
10556:Chlorpromazine
10553:
10548:
10543:
10538:
10533:
10528:
10519:
10518:
10509:
10508:
10503:
10498:
10493:
10488:
10483:
10478:
10473:
10468:
10463:
10458:
10453:
10444:
10443:
10438:
10433:
10428:
10423:
10418:
10413:
10404:
10402:
10398:
10397:
10395:
10394:
10389:
10384:
10379:
10369:
10364:
10359:
10354:
10349:
10344:
10339:
10334:
10324:
10314:
10309:
10304:
10299:
10294:
10289:
10280:
10279:
10274:
10269:
10264:
10259:
10254:
10249:
10244:
10239:
10230:
10229:
10224:
10219:
10214:
10209:
10204:
10199:
10194:
10186:
10181:
10176:
10171:
10166:
10161:
10156:
10151:
10146:
10141:
10132:
10130:
10126:
10121:
10120:
10118:
10117:
10112:
10107:
10102:
10097:
10092:
10087:
10082:
10077:
10072:
10067:
10062:
10057:
10052:
10047:
10042:
10032:
10022:
10014:
10009:
10004:
9999:
9997:Chlorpromazine
9994:
9989:
9984:
9979:
9974:
9969:
9964:
9959:
9954:
9949:
9940:
9939:
9934:
9918:
9917:
9912:
9907:
9902:
9897:
9892:
9887:
9882:
9877:
9872:
9867:
9862:
9857:
9852:
9850:E-52862 (S1RA)
9847:
9842:
9837:
9832:
9827:
9822:
9817:
9812:
9807:
9802:
9797:
9792:
9783:
9782:
9777:
9772:
9767:
9762:
9757:
9752:
9747:
9742:
9737:
9732:
9727:
9722:
9717:
9715:Neuropeptide Y
9712:
9707:
9702:
9697:
9692:
9687:
9679:
9674:
9669:
9664:
9659:
9654:
9649:
9644:
9639:
9634:
9629:
9624:
9619:
9614:
9609:
9604:
9599:
9597:Dextrallorphan
9594:
9584:
9574:
9569:
9564:
9559:
9554:
9544:
9539:
9534:
9529:
9524:
9519:
9514:
9509:
9504:
9499:
9494:
9485:
9483:
9479:
9474:
9473:
9467:Sigma receptor
9463:
9462:
9455:
9448:
9440:
9431:
9430:
9394:
9391:
9390:
9388:
9387:
9375:
9363:
9362:
9357:DAT enhancers:
9353:
9351:
9347:
9346:
9344:
9343:
9338:
9333:
9328:
9323:
9318:
9313:
9308:
9303:
9298:
9293:
9288:
9283:
9278:
9273:
9268:
9263:
9258:
9253:
9235:
9229:
9227:
9216:
9215:
9212:
9211:
9209:
9208:
9203:
9173:
9168:
9163:
9158:
9153:
9148:
9143:
9138:
9133:
9128:
9123:
9118:
9092:
9081:Antipsychotics
9078:
9075:tripelennamine
9059:dimenhydrinate
9055:chlorphenamine
9047:Antihistamines
9044:
9039:
9030:
9027:
9026:
9024:
9023:
9018:
9013:
9008:
9003:
8998:
8993:
8988:
8983:
8981:Cyanodothiepin
8978:
8973:
8968:
8959:
8956:
8955:
8953:
8952:
8942:
8937:
8932:
8927:
8922:
8917:
8912:
8907:
8902:
8897:
8892:
8887:
8882:
8877:
8872:
8867:
8862:
8857:
8852:
8847:
8842:
8837:
8832:
8827:
8822:
8817:
8812:
8807:
8802:
8797:
8792:
8787:
8782:
8777:
8772:
8767:
8758:
8755:
8754:
8752:
8751:
8746:
8741:
8736:
8731:
8726:
8721:
8716:
8711:
8706:
8704:Desvenlafaxine
8701:
8696:
8691:
8682:
8679:
8678:
8676:
8675:
8670:
8665:
8660:
8655:
8650:
8645:
8640:
8635:
8630:
8621:
8620:
8615:
8610:
8605:
8600:
8595:
8590:
8585:
8580:
8575:
8570:
8565:
8560:
8555:
8550:
8545:
8540:
8535:
8530:
8525:
8520:
8515:
8510:
8505:
8496:
8490:
8466:
8465:
8462:
8461:
8459:
8458:
8428:
8423:
8418:
8411:
8406:
8401:
8387:
8376:Antipsychotics
8373:
8370:tripelennamine
8362:chlorphenamine
8354:Antihistamines
8347:
8344:
8343:
8341:
8340:
8335:
8330:
8325:
8320:
8311:
8308:
8307:
8305:
8304:
8299:
8294:
8289:
8284:
8279:
8274:
8269:
8264:
8259:
8254:
8249:
8244:
8235:
8232:
8231:
8229:
8228:
8218:
8213:
8208:
8203:
8198:
8193:
8188:
8183:
8178:
8173:
8168:
8163:
8158:
8153:
8148:
8143:
8138:
8133:
8128:
8123:
8118:
8113:
8108:
8103:
8098:
8093:
8088:
8083:
8078:
8073:
8068:
8063:
8058:
8053:
8048:
8043:
8034:
8031:
8030:
8028:
8027:
8022:
8017:
8012:
8007:
8002:
7997:
7992:
7987:
7982:
7977:
7975:Desvenlafaxine
7972:
7967:
7958:
7955:
7954:
7952:
7951:
7946:
7941:
7936:
7931:
7926:
7921:
7916:
7911:
7906:
7901:
7896:
7891:
7886:
7881:
7872:
7869:
7868:
7866:
7865:
7860:
7855:
7850:
7845:
7840:
7835:
7830:
7825:
7820:
7815:
7810:
7805:
7800:
7795:
7786:
7780:
7756:
7755:
7752:
7751:
7749:
7748:
7743:
7741:Tripelennamine
7738:
7733:
7728:
7723:
7718:
7713:
7708:
7703:
7698:
7693:
7688:
7683:
7678:
7673:
7668:
7663:
7658:
7653:
7648:
7643:
7638:
7633:
7628:
7623:
7618:
7613:
7608:
7603:
7598:
7593:
7588:
7583:
7578:
7573:
7568:
7563:
7558:
7553:
7548:
7543:
7538:
7533:
7528:
7523:
7518:
7513:
7508:
7503:
7498:
7491:
7486:
7481:
7476:
7471:
7466:
7464:Amfonelic acid
7461:
7456:
7451:
7442:
7439:
7438:
7436:
7435:
7430:
7425:
7420:
7415:
7410:
7405:
7400:
7395:
7390:
7385:
7380:
7375:
7370:
7365:
7360:
7355:
7350:
7345:
7340:
7335:
7330:
7325:
7320:
7315:
7310:
7305:
7296:
7293:
7292:
7290:
7289:
7284:
7279:
7274:
7269:
7260:
7257:
7256:
7254:
7253:
7248:
7243:
7238:
7233:
7228:
7223:
7218:
7216:Ethylphenidate
7213:
7208:
7203:
7198:
7193:
7184:
7181:
7180:
7178:
7177:
7172:
7167:
7162:
7157:
7152:
7147:
7142:
7133:
7127:
7103:
7102:
7095:
7094:
7087:
7080:
7072:
7063:
7062:
7060:
7059:
7037:
7026:
7024:
7020:
7019:
7017:
7016:
7001:
6986:
6950:
6948:
6942:
6941:
6931:
6930:
6923:
6916:
6908:
6899:
6898:
6895:
6894:
6893:
6892:
6889:
6878:
6872:
6866:
6865:
6862:
6861:
6859:
6858:
6853:
6848:
6843:
6838:
6833:
6828:
6823:
6818:
6813:
6808:
6803:
6798:
6793:
6788:
6783:
6778:
6772:
6770:
6766:
6765:
6763:
6762:
6752:
6734:
6723:
6721:
6711:Sympatholytics
6707:
6706:
6704:
6703:
6698:
6692:
6690:
6688:Antipsychotics
6684:
6683:
6681:
6680:
6675:
6670:
6665:
6660:
6639:
6624:
6609:
6594:
6579:
6563:
6561:
6555:
6554:
6552:
6551:
6546:
6541:
6536:
6530:
6528:
6514:
6506:Gabapentinoids
6502:
6501:
6499:
6498:
6492:
6490:
6484:
6483:
6481:
6480:
6475:
6470:
6465:
6460:
6450:
6440:
6428:
6423:
6418:
6413:
6408:
6403:
6398:
6393:
6388:
6383:
6378:
6373:
6368:
6363:
6358:
6353:
6348:
6343:
6338:
6333:
6328:
6316:
6314:
6297:
6291:
6290:
6288:
6287:
6282:
6277:
6271:
6269:
6257:
6251:
6250:
6238:
6237:
6230:
6223:
6215:
6206:
6205:
6202:
6201:
6200:
6199:
6196:
6185:
6179:
6173:
6172:
6169:
6168:
6165:
6164:
6162:
6161:
6156:
6151:
6142:
6134:
6117:
6111:Ademetionine (
6107:
6104:
6103:
6093:
6092:
6089:
6088:
6086:
6085:
6081:
6073:
6063:
6049:
6044:
6013:
6010:
6009:
5997:
5996:
5993:
5992:
5989:
5988:
5986:
5985:
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5905:
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5876:
5875:
5870:
5865:
5860:
5855:
5850:
5845:
5840:
5835:
5830:
5825:
5820:
5815:
5810:
5805:
5800:
5791:
5789:
5781:
5780:
5768:
5767:
5764:
5763:
5760:
5759:
5757:
5756:
5750:
5748:
5744:
5743:
5741:
5740:
5735:
5730:
5725:
5719:
5717:
5706:
5705:
5703:
5702:
5697:
5692:
5687:
5682:
5677:
5672:
5667:
5662:
5657:
5652:
5647:
5642:
5637:
5632:
5630:Imipraminoxide
5627:
5622:
5617:
5612:
5607:
5602:
5597:
5592:
5587:
5582:
5577:
5572:
5567:
5561:
5559:
5544:
5543:
5527:
5526:
5523:
5522:
5519:
5518:
5516:
5515:
5510:
5505:
5500:
5495:
5490:
5485:
5480:
5475:
5470:
5465:
5460:
5455:
5450:
5445:
5440:
5434:
5432:
5428:
5427:
5425:
5424:
5419:
5413:
5411:
5400:
5399:
5397:
5396:
5391:
5386:
5380:
5378:
5367:
5366:
5364:
5363:
5358:
5353:
5347:
5345:
5334:
5333:
5331:
5330:
5325:
5320:
5314:
5312:
5301:
5300:
5298:
5297:
5292:
5287:
5281:
5279:
5268:
5267:
5265:
5264:
5259:
5254:
5249:
5244:
5239:
5237:Desvenlafaxine
5233:
5231:
5220:
5219:
5217:
5216:
5211:
5206:
5201:
5196:
5191:
5186:
5181:
5175:
5173:
5158:
5157:
5140:
5139:
5127:
5126:
5119:
5112:
5104:
5098:
5097:
5080:
5079:External links
5077:
5074:
5073:
5043:
5021:
4996:
4968:
4943:
4917:
4890:
4859:
4829:
4797:
4782:
4730:
4694:
4659:
4630:(5): 409–418.
4610:
4561:
4518:
4489:(4): 185–196.
4469:
4439:
4427:
4392:
4385:
4367:
4334:
4305:(3): 287–290.
4285:
4258:(6): 626–633.
4241:
4235:978-0962652370
4234:
4216:
4197:(2): 299–305.
4181:
4135:
4108:(4): 436–443.
4091:
4056:
4049:
4024:
3998:
3971:(3): 125–127.
3955:
3936:(3): 359–360.
3920:
3885:
3849:
3814:
3765:
3732:
3702:
3672:
3623:
3604:(3): 404–408.
3585:
3552:
3523:(3): e034560.
3500:
3477:
3420:
3371:
3336:
3299:
3262:
3229:
3197:
3162:
3113:
3072:
3053:(2): 121–129.
3036:
2989:
2945:
2910:
2861:
2802:
2773:(2): 214–232.
2753:
2722:
2673:
2647:
2617:
2587:
2543:
2518:
2488:
2460:
2430:
2400:
2357:
2338:(4): 281–290.
2303:
2284:(1): 121–128.
2251:
2214:
2185:
2151:
2140:. 21 June 2022
2125:
2096:
2075:"Escitalopram"
2062:
2061:
2059:
2056:
2055:
2054:
2047:
2044:
2030:
2027:
2009:
2006:
2000:
1997:
1995:
1992:
1963:
1960:
1936:
1933:
1917:P-glycoprotein
1912:
1909:
1874:
1859:
1858:
1854:
1851:
1845:
1844:
1841:
1835:
1834:
1831:
1827:
1822:
1821:
1818:
1814:
1809:
1808:
1805:
1801:
1796:
1795:
1792:
1788:
1783:
1782:
1779:
1775:
1770:
1769:
1766:
1762:
1757:
1756:
1753:
1749:
1744:
1743:
1740:
1734:
1733:
1730:
1724:
1723:
1720:
1714:
1713:
1709:
1706:
1696:
1693:
1691:
1688:
1665:
1641:antihistamines
1633:antipsychotics
1623:on platelets.
1601:anticoagulants
1593:mefenamic acid
1463:
1460:
1458:, citalopram.
1422:
1419:
1409:
1406:
1396:
1393:
1358:Main article:
1355:
1352:
1339:
1336:
1334:
1333:
1330:
1327:
1322:
1316:
1311:
1305:
1299:
1293:
1287:
1281:
1278:
1273:
1268:
1263:
1262:Dilated pupils
1260:
1255:
1252:
1247:
1241:
1238:
1233:
1228:
1221:
1216:
1213:
1212:
1211:
1208:
1205:
1202:
1199:
1198:Headache (24%)
1191:
1188:
1152:antiarrhythmic
1079:
1076:
1063:
1060:
1043:
1040:
1026:
1023:
1015:panic disorder
990:
987:
928:taken by mouth
912:antidepressant
895:
894:
883:
882:
880:
879:
876:
874:
871:
863:
862:
861:
858:
857:
855:
854:
851:
843:
842:
841:
838:
837:
829:
823:
822:
820:
819:
811:
809:
801:
800:
794:
788:
787:
781:
772:
766:
761:
755:
754:
750:
749:
739:
731:
730:
728:
727:
714:
712:
699:
698:
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687:
685:
679:
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619:
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585:
579:
578:
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554:
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551:
550:
542:
540:
534:
533:
531:
530:
523:
515:
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513:
510:
509:
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504:
494:
488:
487:
484:
475:
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463:
457:
456:
438:
432:
431:
428:
422:
421:
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412:
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404:
403:
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388:
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360:
349:
336:
322:
320:
314:
313:
309:
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305:
292:
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284:
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277:
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257:
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241:
239:
231:
230:
228:
227:
209:
207:
201:
200:
193:
187:
186:
179:
169:
168:
155:)-Citalopram;
149:
145:
144:
141:
135:
134:
68:
64:
63:
59:
58:
50:
49:
15:
9:
6:
4:
3:
2:
10780:
10769:
10766:
10764:
10761:
10759:
10756:
10754:
10751:
10749:
10746:
10744:
10741:
10739:
10736:
10734:
10731:
10729:
10726:
10724:
10721:
10720:
10718:
10708:
10698:
10697:
10694:
10683:
10682:
10679:
10673:
10667:
10664:
10662:
10659:
10657:
10654:
10652:
10649:
10647:
10644:
10642:
10639:
10637:
10634:
10632:
10629:
10627:
10624:
10622:
10619:
10617:
10614:
10612:
10609:
10607:
10604:
10602:
10599:
10597:
10594:
10591:
10587:
10584:
10582:
10579:
10577:
10574:
10572:
10569:
10567:
10564:
10562:
10559:
10557:
10554:
10552:
10549:
10547:
10544:
10542:
10539:
10537:
10534:
10532:
10529:
10527:
10524:
10521:
10520:
10517:
10514:
10511:
10510:
10507:
10504:
10502:
10499:
10497:
10494:
10492:
10489:
10487:
10484:
10482:
10479:
10477:
10474:
10472:
10469:
10467:
10464:
10462:
10459:
10457:
10454:
10452:
10449:
10446:
10445:
10442:
10441:Tenocyclidine
10439:
10437:
10434:
10432:
10429:
10427:
10424:
10422:
10419:
10417:
10414:
10412:
10409:
10406:
10405:
10403:
10399:
10393:
10390:
10388:
10385:
10383:
10380:
10375:
10370:
10368:
10365:
10363:
10360:
10358:
10355:
10353:
10350:
10348:
10345:
10343:
10340:
10338:
10335:
10330:
10325:
10320:
10315:
10313:
10310:
10308:
10305:
10303:
10300:
10298:
10295:
10293:
10290:
10288:
10285:
10282:
10281:
10278:
10275:
10273:
10270:
10268:
10265:
10263:
10260:
10258:
10255:
10253:
10250:
10248:
10245:
10243:
10240:
10238:
10235:
10232:
10231:
10228:
10225:
10223:
10220:
10218:
10217:Phencyclidine
10215:
10213:
10210:
10208:
10205:
10203:
10200:
10198:
10195:
10193:
10187:
10185:
10182:
10180:
10177:
10175:
10172:
10170:
10167:
10165:
10162:
10160:
10157:
10155:
10152:
10150:
10147:
10145:
10142:
10140:
10137:
10134:
10133:
10131:
10129:
10122:
10116:
10113:
10111:
10108:
10106:
10103:
10101:
10098:
10096:
10093:
10091:
10088:
10086:
10083:
10081:
10078:
10076:
10073:
10071:
10068:
10066:
10063:
10061:
10058:
10056:
10053:
10051:
10048:
10046:
10043:
10038:
10033:
10028:
10023:
10021:
10015:
10013:
10010:
10008:
10005:
10003:
10000:
9998:
9995:
9993:
9990:
9988:
9987:Amitriptyline
9985:
9983:
9980:
9978:
9975:
9973:
9970:
9968:
9965:
9963:
9960:
9958:
9955:
9953:
9950:
9948:
9945:
9942:
9941:
9938:
9935:
9933:
9930:
9926:
9923:
9920:
9919:
9916:
9913:
9911:
9908:
9906:
9903:
9901:
9898:
9896:
9893:
9891:
9888:
9886:
9883:
9881:
9878:
9876:
9873:
9871:
9868:
9866:
9863:
9861:
9858:
9856:
9853:
9851:
9848:
9846:
9843:
9841:
9838:
9836:
9833:
9831:
9828:
9826:
9823:
9821:
9818:
9816:
9813:
9811:
9808:
9806:
9803:
9801:
9798:
9796:
9793:
9791:
9788:
9785:
9784:
9781:
9778:
9776:
9773:
9771:
9768:
9766:
9763:
9761:
9758:
9756:
9753:
9751:
9748:
9746:
9743:
9741:
9738:
9736:
9733:
9731:
9728:
9726:
9723:
9721:
9718:
9716:
9713:
9711:
9708:
9706:
9703:
9701:
9700:Methoxetamine
9698:
9696:
9693:
9691:
9688:
9686:
9680:
9678:
9675:
9673:
9670:
9668:
9665:
9663:
9660:
9658:
9655:
9653:
9650:
9648:
9645:
9643:
9640:
9638:
9635:
9633:
9630:
9628:
9625:
9623:
9620:
9618:
9615:
9613:
9610:
9608:
9605:
9603:
9600:
9598:
9595:
9592:
9588:
9585:
9582:
9578:
9575:
9573:
9570:
9568:
9565:
9563:
9560:
9558:
9555:
9550:
9545:
9543:
9540:
9538:
9535:
9533:
9530:
9528:
9525:
9523:
9520:
9518:
9515:
9513:
9510:
9508:
9505:
9503:
9500:
9498:
9495:
9493:
9490:
9487:
9486:
9484:
9482:
9475:
9471:
9468:
9461:
9456:
9454:
9449:
9447:
9442:
9441:
9438:
9427:
9426:
9422:
9418:
9417:Serotonergics
9414:
9413:Dopaminergics
9410:
9406:
9402:
9399:
9392:
9386:
9383:
9379:
9376:
9374:
9371:
9370:Agonist-like:
9368:
9365:
9364:
9361:
9358:
9355:
9354:
9352:
9348:
9342:
9339:
9337:
9334:
9332:
9331:Tetrabenazine
9329:
9327:
9324:
9322:
9319:
9317:
9314:
9312:
9309:
9307:
9304:
9302:
9299:
9297:
9294:
9292:
9289:
9287:
9284:
9282:
9279:
9277:
9274:
9272:
9269:
9267:
9264:
9262:
9259:
9257:
9254:
9251:
9247:
9243:
9239:
9236:
9234:
9231:
9230:
9228:
9223:
9217:
9207:
9204:
9201:
9197:
9193:
9189:
9185:
9181:
9177:
9174:
9172:
9169:
9167:
9164:
9162:
9159:
9157:
9154:
9152:
9149:
9147:
9144:
9142:
9139:
9137:
9134:
9132:
9129:
9127:
9124:
9122:
9119:
9116:
9115:phencyclidine
9112:
9111:methoxetamine
9108:
9104:
9100:
9096:
9093:
9090:
9086:
9082:
9079:
9076:
9072:
9068:
9064:
9060:
9056:
9052:
9048:
9045:
9043:
9040:
9038:
9035:
9032:
9031:
9028:
9022:
9021:Protriptyline
9019:
9017:
9014:
9012:
9011:Nortriptyline
9009:
9007:
9004:
9002:
8999:
8997:
8994:
8992:
8989:
8987:
8984:
8982:
8979:
8977:
8974:
8972:
8969:
8967:
8966:Amitriptyline
8964:
8961:
8960:
8957:
8950:
8946:
8943:
8941:
8938:
8936:
8933:
8931:
8930:Tedatioxetine
8928:
8926:
8923:
8921:
8918:
8916:
8913:
8911:
8908:
8906:
8903:
8901:
8898:
8896:
8893:
8891:
8888:
8886:
8883:
8881:
8878:
8876:
8873:
8871:
8868:
8866:
8863:
8861:
8858:
8856:
8853:
8851:
8848:
8846:
8843:
8841:
8838:
8836:
8833:
8831:
8828:
8826:
8823:
8821:
8818:
8816:
8813:
8811:
8808:
8806:
8803:
8801:
8798:
8796:
8793:
8791:
8790:Centanafadine
8788:
8786:
8783:
8781:
8778:
8776:
8773:
8771:
8768:
8766:
8763:
8760:
8759:
8756:
8750:
8747:
8745:
8742:
8740:
8737:
8735:
8734:N-Methyl-PPPA
8732:
8730:
8727:
8725:
8722:
8720:
8717:
8715:
8712:
8710:
8707:
8705:
8702:
8700:
8697:
8695:
8692:
8690:
8687:
8684:
8683:
8680:
8674:
8671:
8669:
8666:
8664:
8661:
8659:
8656:
8654:
8651:
8649:
8646:
8644:
8641:
8639:
8636:
8634:
8631:
8629:
8626:
8623:
8622:
8619:
8616:
8614:
8611:
8609:
8606:
8604:
8601:
8599:
8596:
8594:
8591:
8589:
8586:
8584:
8581:
8579:
8576:
8574:
8573:Norfluoxetine
8571:
8569:
8566:
8564:
8561:
8559:
8556:
8554:
8551:
8549:
8546:
8544:
8541:
8539:
8536:
8534:
8531:
8529:
8526:
8524:
8521:
8519:
8516:
8514:
8513:Centpropazine
8511:
8509:
8506:
8504:
8501:
8498:
8497:
8494:
8491:
8484:
8473:
8467:
8456:
8452:
8448:
8444:
8440:
8436:
8435:desmetramadol
8432:
8429:
8427:
8424:
8422:
8419:
8417:
8416:
8415:Ginkgo biloba
8412:
8410:
8407:
8405:
8402:
8399:
8398:phencyclidine
8395:
8391:
8388:
8385:
8381:
8377:
8374:
8371:
8367:
8363:
8359:
8355:
8352:
8349:
8348:
8345:
8339:
8336:
8334:
8331:
8329:
8326:
8324:
8321:
8319:
8316:
8313:
8312:
8309:
8303:
8300:
8298:
8297:Protriptyline
8295:
8293:
8292:Nortriptyline
8290:
8288:
8285:
8283:
8280:
8278:
8275:
8273:
8270:
8268:
8265:
8263:
8260:
8258:
8255:
8253:
8250:
8248:
8245:
8243:
8242:Amitriptyline
8240:
8237:
8236:
8233:
8226:
8222:
8219:
8217:
8214:
8212:
8209:
8207:
8206:Tedatioxetine
8204:
8202:
8199:
8197:
8194:
8192:
8189:
8187:
8184:
8182:
8179:
8177:
8174:
8172:
8169:
8167:
8164:
8162:
8159:
8157:
8154:
8152:
8149:
8147:
8144:
8142:
8139:
8137:
8134:
8132:
8129:
8127:
8124:
8122:
8119:
8117:
8114:
8112:
8109:
8107:
8104:
8102:
8099:
8097:
8094:
8092:
8089:
8087:
8084:
8082:
8079:
8077:
8074:
8072:
8069:
8067:
8066:Centanafadine
8064:
8062:
8059:
8057:
8054:
8052:
8049:
8047:
8044:
8042:
8039:
8036:
8035:
8032:
8026:
8023:
8021:
8018:
8016:
8013:
8011:
8008:
8006:
8005:N-Methyl-PPPA
8003:
8001:
7998:
7996:
7993:
7991:
7988:
7986:
7983:
7981:
7978:
7976:
7973:
7971:
7968:
7966:
7963:
7960:
7959:
7956:
7950:
7947:
7945:
7942:
7940:
7937:
7935:
7932:
7930:
7927:
7925:
7922:
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7917:
7915:
7912:
7910:
7907:
7905:
7902:
7900:
7897:
7895:
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7890:
7887:
7885:
7882:
7880:
7877:
7874:
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7870:
7864:
7861:
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7856:
7854:
7851:
7849:
7846:
7844:
7841:
7839:
7836:
7834:
7831:
7829:
7826:
7824:
7821:
7819:
7816:
7814:
7811:
7809:
7806:
7804:
7801:
7799:
7796:
7794:
7791:
7788:
7787:
7784:
7781:
7774:
7763:
7757:
7747:
7744:
7742:
7739:
7737:
7734:
7732:
7731:Tedatioxetine
7729:
7727:
7724:
7722:
7719:
7717:
7714:
7712:
7709:
7707:
7704:
7702:
7699:
7697:
7694:
7692:
7689:
7687:
7684:
7682:
7679:
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7639:
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7634:
7632:
7629:
7627:
7624:
7622:
7619:
7617:
7614:
7612:
7609:
7607:
7604:
7602:
7599:
7597:
7594:
7592:
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7584:
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7579:
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7574:
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7569:
7567:
7564:
7562:
7559:
7557:
7554:
7552:
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7539:
7537:
7534:
7532:
7529:
7527:
7524:
7522:
7519:
7517:
7514:
7512:
7509:
7507:
7504:
7502:
7499:
7497:
7496:
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7490:
7487:
7485:
7482:
7480:
7477:
7475:
7472:
7470:
7467:
7465:
7462:
7460:
7457:
7455:
7452:
7450:
7447:
7444:
7443:
7440:
7434:
7431:
7429:
7426:
7424:
7421:
7419:
7416:
7414:
7411:
7409:
7406:
7404:
7401:
7399:
7396:
7394:
7391:
7389:
7386:
7384:
7381:
7379:
7376:
7374:
7371:
7369:
7366:
7364:
7361:
7359:
7356:
7354:
7353:Ioflupane (I)
7351:
7349:
7346:
7344:
7341:
7339:
7336:
7334:
7331:
7329:
7326:
7324:
7321:
7319:
7316:
7314:
7311:
7309:
7306:
7304:
7301:
7298:
7297:
7294:
7288:
7285:
7283:
7280:
7278:
7275:
7273:
7270:
7268:
7265:
7264:Pyrrolidines:
7262:
7261:
7258:
7252:
7251:Tenocyclidine
7249:
7247:
7244:
7242:
7239:
7237:
7236:Phencyclidine
7234:
7232:
7229:
7227:
7224:
7222:
7219:
7217:
7214:
7212:
7209:
7207:
7204:
7202:
7199:
7197:
7194:
7192:
7189:
7186:
7185:
7182:
7176:
7173:
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7168:
7166:
7163:
7161:
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7156:
7153:
7151:
7148:
7146:
7143:
7141:
7138:
7135:
7134:
7131:
7128:
7121:
7110:
7104:
7100:
7093:
7088:
7086:
7081:
7079:
7074:
7073:
7070:
7057:
7053:
7049:
7045:
7041:
7038:
7035:
7031:
7028:
7027:
7025:
7021:
7014:
7007:
7002:
6999:
6992:
6987:
6984:
6980:
6976:
6972:
6968:
6964:
6957:
6952:
6951:
6949:
6947:
6943:
6939:
6929:
6924:
6922:
6917:
6915:
6910:
6909:
6906:
6890:
6888:
6885:
6884:
6882:
6879:
6876:
6873:
6871:
6868:
6867:
6863:
6857:
6854:
6852:
6849:
6847:
6844:
6842:
6839:
6837:
6834:
6832:
6829:
6827:
6826:Phenaglycodol
6824:
6822:
6819:
6817:
6814:
6812:
6809:
6807:
6804:
6802:
6799:
6797:
6794:
6792:
6789:
6787:
6784:
6782:
6779:
6777:
6774:
6773:
6771:
6767:
6760:
6756:
6755:Beta blockers
6753:
6750:
6746:
6742:
6738:
6735:
6732:
6728:
6725:
6724:
6722:
6718:
6712:
6708:
6702:
6699:
6697:
6694:
6693:
6691:
6689:
6685:
6679:
6676:
6674:
6671:
6669:
6666:
6664:
6661:
6659:
6656:
6652:
6645:
6640:
6637:
6630:
6625:
6622:
6615:
6610:
6607:
6600:
6595:
6592:
6585:
6580:
6577:
6570:
6565:
6564:
6562:
6560:
6556:
6550:
6547:
6545:
6542:
6540:
6537:
6535:
6532:
6531:
6529:
6525:
6522:
6507:
6503:
6497:
6494:
6493:
6491:
6489:
6485:
6479:
6476:
6474:
6471:
6469:
6468:Chlormezanone
6466:
6464:
6461:
6458:
6454:
6451:
6448:
6447:phenobarbital
6444:
6441:
6439:
6436:
6432:
6429:
6427:
6424:
6422:
6419:
6417:
6414:
6412:
6409:
6407:
6404:
6402:
6399:
6397:
6394:
6392:
6389:
6387:
6384:
6382:
6379:
6377:
6374:
6372:
6369:
6367:
6364:
6362:
6359:
6357:
6354:
6352:
6349:
6347:
6344:
6342:
6339:
6337:
6334:
6332:
6329:
6327:
6324:
6322:
6318:
6317:
6315:
6310:
6302:
6292:
6286:
6283:
6281:
6278:
6276:
6273:
6272:
6270:
6268:
6262:
6252:
6247:
6243:
6236:
6231:
6229:
6224:
6222:
6217:
6216:
6213:
6197:
6195:
6192:
6191:
6189:
6186:
6183:
6180:
6178:
6175:
6174:
6170:
6160:
6157:
6155:
6152:
6150:
6143:
6141:
6139:
6135:
6132:
6128:
6124:
6123:neurosteroids
6121:
6118:
6116:
6109:
6108:
6105:
6101:Miscellaneous
6098:
6094:
6079:
6078:levothyroxine
6071:
6067:
6064:
6061:
6057:
6053:
6050:
6048:
6045:
6042:
6038:
6034:
6030:
6026:
6025:brexpiprazole
6022:
6018:
6015:
6014:
6011:
6007:
6002:
5998:
5984:
5981:
5980:Irreversible:
5978:
5977:
5975:
5969:
5960:
5954:
5951:
5949:
5946:
5944:
5941:
5939:
5936:
5934:
5931:
5929:
5926:
5924:
5921:
5918:
5917:
5915:
5909:
5900:
5894:
5891:
5888:
5887:
5884:
5881:
5878:
5877:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5813:Isocarboxazid
5811:
5809:
5806:
5804:
5801:
5799:
5796:
5795:Irreversible:
5793:
5792:
5790:
5788:Non-selective
5786:
5782:
5778:
5773:
5769:
5755:
5752:
5751:
5749:
5745:
5739:
5736:
5734:
5731:
5729:
5726:
5724:
5721:
5720:
5718:
5713:
5707:
5701:
5698:
5696:
5693:
5691:
5688:
5686:
5685:Protriptyline
5683:
5681:
5678:
5676:
5673:
5671:
5668:
5666:
5663:
5661:
5660:Nortriptyline
5658:
5656:
5655:Nitroxazepine
5653:
5651:
5648:
5646:
5643:
5641:
5638:
5636:
5633:
5631:
5628:
5626:
5623:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5595:Demexiptiline
5593:
5591:
5588:
5586:
5583:
5581:
5578:
5576:
5573:
5571:
5570:Amitriptyline
5568:
5566:
5563:
5562:
5560:
5555:
5549:
5545:
5541:
5537:
5532:
5528:
5514:
5511:
5509:
5506:
5504:
5501:
5499:
5496:
5494:
5491:
5489:
5486:
5484:
5481:
5479:
5476:
5474:
5471:
5469:
5466:
5464:
5461:
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5446:
5444:
5441:
5439:
5436:
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5412:
5407:
5401:
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5368:
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5319:
5316:
5315:
5313:
5308:
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5288:
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5280:
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5260:
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4978:
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4954:
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4931:
4927:
4921:
4905:
4902:. FirstWord.
4901:
4894:
4878:
4874:
4870:
4863:
4847:
4843:
4842:Gdziepolek.pl
4839:
4833:
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4801:
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4060:
4052:
4050:9780890425558
4046:
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4012:
4008:
4002:
3994:
3990:
3986:
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3351:
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3340:
3321:
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3310:
3303:
3284:
3280:
3273:
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3250:
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3214:
3207:
3201:
3193:
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3076:
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3016:
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3008:
3004:
3000:
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2973:
2969:
2965:
2961:
2957:
2949:
2941:
2937:
2933:
2929:
2925:
2922:(in French).
2921:
2914:
2906:
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2897:
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2876:
2872:
2865:
2857:
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2848:
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2833:
2829:
2825:
2822:(8): e42003.
2821:
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2813:
2806:
2798:
2794:
2789:
2784:
2780:
2776:
2772:
2768:
2764:
2757:
2749:
2745:
2741:
2737:
2733:
2732:NIHR Evidence
2726:
2718:
2714:
2709:
2704:
2700:
2696:
2692:
2688:
2684:
2677:
2669:
2665:
2661:
2660:NIHR Evidence
2657:
2651:
2635:
2631:
2627:
2621:
2605:
2601:
2597:
2591:
2575:
2570:
2565:
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2198:
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2190:
2173:
2169:
2165:
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2155:
2139:
2135:
2129:
2114:
2110:
2106:
2100:
2084:
2080:
2076:
2070:
2068:
2063:
2053:
2050:
2049:
2043:
2040:
2035:
2026:
2022:
2020:
2016:
2005:
1991:
1989:
1985:
1981:
1973:
1968:
1959:
1958:citalopram.
1957:
1953:
1950:
1946:
1942:
1932:
1930:
1926:
1922:
1918:
1908:
1905:
1901:
1897:
1893:
1889:
1884:
1882:
1878:
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1866:
1852:
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1847:
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1837:
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1832:
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1824:
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1819:
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1811:
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1806:
1804:
1798:
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1687:
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1677:
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1669:
1661:
1658:
1654:
1650:
1646:
1642:
1638:
1634:
1630:
1624:
1622:
1619:via blocking
1618:
1614:
1611:, and garlic
1610:
1606:
1602:
1598:
1594:
1590:
1586:
1582:
1577:
1575:
1571:
1567:
1563:
1559:
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1548:
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1536:
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1521:
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1497:
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1300:
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1279:
1277:
1274:
1272:
1269:
1267:
1264:
1261:
1259:
1256:
1253:
1251:
1248:
1245:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1223:
1222:
1220:
1209:
1206:
1203:
1200:
1197:
1196:
1195:
1187:
1185:
1181:
1176:
1172:
1168:
1164:
1159:
1157:
1153:
1148:
1147:amitriptyline
1144:
1138:
1136:
1131:
1127:
1123:
1119:
1115:
1111:
1108:
1104:
1099:
1097:
1093:
1089:
1085:
1075:
1073:
1069:
1059:
1057:
1053:
1049:
1039:
1037:
1031:
1022:
1020:
1016:
1012:
1008:
1004:
1000:
996:
986:
980:
976:
972:
971:United States
967:
966:-citalopram.
965:
961:
957:
953:
949:
945:
944:breastfeeding
941:
935:
933:
929:
925:
921:
917:
913:
909:
905:
901:
891:
884:
875:
870:
869:
866:
859:
850:
849:
846:
839:
836:
833:
830:
828:
824:
817:
813:
812:
810:
807:
802:
795:
793:
789:
762:
760:
756:
751:
747:
743:
740:
738:
736:ECHA InfoCard
732:
724:
720:
719:DTXSID8048440
716:
715:
713:
704:
700:
693:
689:
688:
686:
684:
680:
673:
669:
668:
666:
664:
660:
653:
649:
648:
646:
644:
640:
633:
629:
628:
626:
624:
620:
613:
609:
608:
606:
604:
600:
593:
589:
588:
586:
584:
580:
573:
569:
568:
566:
559:
555:
548:
544:
543:
541:
539:
535:
527:
522:
521:
518:
511:
506:
502:
498:
495:
493:
489:
485:
483:
476:
473:
468:
464:
462:
458:
454:
450:
446:
442:
439:
437:
433:
430:~55–56% (low)
429:
427:
423:
419:
417:
413:
409:
405:
398:
396: Rx-only
389:
386:
374:
371:
361:
359:
350:
347:
337:
334:
324:
323:
321:
319:
315:
310:
302:
297:
294:
293:
291:
289:
285:
281:
278:
276:
272:
269:
266:
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258:
252:
243:
242:
240:
238:
232:
225:
220:
211:
210:
208:
206:
202:
198:
194:
192:
188:
184:
180:
178:
174:
170:
166:
162:
159:-Citalopram;
158:
154:
150:
146:
142:
140:
136:
129:
127:pronunciation
119:
69:
67:Pronunciation
65:
62:Clinical data
60:
56:
51:
47:
42:
34:
30:
26:
22:
10677:
10676:
10631:Promethazine
10616:Perphenazine
10596:Fluphenazine
10571:Clocapramine
10546:Carvotroline
10522:
10512:
10448:Antagonists:
10447:
10407:
10283:
10234:Antagonists:
10233:
10135:
10007:Clomipramine
9943:
9928:
9921:
9900:Progesterone
9787:Antagonists:
9786:
9750:Pregnenolone
9637:Escitalopram
9636:
9557:Cloperastine
9532:Blarcamesine
9488:
9397:
9396:
9381:
9369:
9366:
9356:
9266:Bietaserpine
9238:Amphetamines
9161:Mifepristone
9151:Medifoxamine
9033:
8976:Clomipramine
8971:Cianopramine
8962:
8815:Diclofensine
8785:Brasofensine
8761:
8685:
8673:Vortioxetine
8624:
8543:Escitalopram
8542:
8499:
8421:Indeloxazine
8413:
8350:
8333:Oxaprotiline
8314:
8302:Trimipramine
8257:Clomipramine
8252:Cianopramine
8247:Butriptyline
8238:
8091:Diclofensine
8061:Brasofensine
8037:
7961:
7949:Solriamfetol
7875:
7858:Teniloxazine
7818:Esreboxetine
7789:
7721:Solriamfetol
7641:Medifoxamine
7531:Dimethocaine
7521:Diclofensine
7493:
7445:
7333:Difluoropine
7328:Dichloropane
7313:Brasofensine
7299:
7287:Pyrovalerone
7263:
7188:Piperidines:
7187:
7137:Piperazines:
7136:
7044:aripiprazole
7013:clomipramine
6967:escitalopram
6966:
6796:Lorpiprazole
6786:Fabomotizole
6776:Benzoctamine
6678:Vortioxetine
6654:
6621:clomipramine
6576:escitalopram
6575:
6463:Carisoprodol
6443:Barbiturates
6434:
6319:
6285:Tandospirone
6145:Oxitriptan (
6137:
6021:aripiprazole
5979:
5928:Metralindole
5919:
5889:
5879:
5858:Pivhydrazine
5848:Pheniprazine
5794:
5700:Trimipramine
5690:Quinupramine
5590:Clomipramine
5585:Butriptyline
5508:Teniloxazine
5503:Tandospirone
5488:Metryptamine
5483:Medifoxamine
5468:Indeloxazine
5422:Vortioxetine
5184:Escitalopram
5183:
5090:
5064:. Retrieved
5055:
5046:
5038:the original
5033:
5024:
5016:the original
5009:
4999:
4988:the original
4983:
4971:
4963:the original
4956:
4946:
4934:. Retrieved
4920:
4908:. Retrieved
4893:
4881:. Retrieved
4872:
4862:
4850:. Retrieved
4846:the original
4841:
4832:
4820:. Retrieved
4800:
4791:
4785:
4750:
4746:
4711:(1): 31–40.
4708:
4704:
4697:
4672:
4668:
4662:
4627:
4623:
4613:
4578:
4574:
4564:
4534:(1): 23–32.
4531:
4527:
4521:
4486:
4482:
4472:
4460:. Retrieved
4451:
4442:
4405:
4401:
4395:
4376:
4370:
4358:. Retrieved
4349:
4302:
4298:
4288:
4255:
4251:
4244:
4225:
4219:
4194:
4190:
4184:
4151:
4147:
4105:
4101:
4094:
4072:(1): 29–34.
4069:
4065:
4059:
4036:
4015:. Retrieved
4011:the original
4001:
3968:
3964:
3958:
3933:
3929:
3923:
3898:
3894:
3888:
3863:
3859:
3852:
3830:(19): 1987.
3827:
3823:
3817:
3782:
3778:
3768:
3756:. Retrieved
3747:
3735:
3723:. Retrieved
3714:
3705:
3693:. Retrieved
3684:
3675:
3640:
3636:
3626:
3601:
3597:
3576:. Retrieved
3520:
3516:
3491:. Retrieved
3480:
3472:
3445:(2): E5–E6.
3442:
3438:
3388:
3384:
3374:
3352:(1): 31–36.
3349:
3345:
3339:
3329:22 September
3327:. Retrieved
3315:
3302:
3292:22 September
3290:. Retrieved
3278:
3265:
3253:. Retrieved
3242:
3232:
3220:. Retrieved
3200:
3178:(1): 27–32.
3175:
3171:
3165:
3130:
3126:
3116:
3089:
3085:
3075:
3050:
3046:
3039:
3006:
3002:
2992:
2959:
2955:
2948:
2926:(1): 86–96.
2923:
2919:
2913:
2878:
2874:
2864:
2819:
2815:
2805:
2770:
2766:
2756:
2731:
2725:
2690:
2686:
2676:
2659:
2650:
2638:. Retrieved
2629:
2620:
2608:. Retrieved
2599:
2590:
2578:. Retrieved
2559:
2555:
2546:
2534:. Retrieved
2530:
2521:
2509:. Retrieved
2500:
2491:
2482:10665/371090
2472:
2463:
2451:. Retrieved
2442:
2433:
2421:. Retrieved
2412:
2403:
2391:. Retrieved
2335:
2331:
2281:
2277:
2242:. Retrieved
2230:
2217:
2205:. Retrieved
2200:
2176:. Retrieved
2154:
2142:. Retrieved
2137:
2128:
2116:. Retrieved
2108:
2099:
2087:. Retrieved
2083:the original
2078:
2036:
2032:
2023:
2011:
2008:Legal status
2002:
1977:
1955:
1940:
1938:
1914:
1885:
1862:
1690:Pharmacology
1625:
1578:
1551:
1528:
1472:aripiprazole
1465:
1462:Interactions
1424:
1415:Apgar scores
1411:
1398:
1381:irritability
1363:
1345:
1341:
1314:Restlessness
1302:Paraesthesia
1250:Constipation
1246:(joint pain)
1218:
1201:Nausea (18%)
1193:
1160:
1139:
1126:moxifloxacin
1112:
1100:
1081:
1078:Side effects
1072:luteal phase
1065:
1045:
1036:evergreening
1032:
1028:
992:
989:Medical uses
968:
963:
947:
936:
907:
903:
900:Escitalopram
899:
898:
887:
832:Levorotatory
525:
486:~27–32 hours
479:Elimination
318:Legal status
312:Legal status
224:Escitalopram
205:License data
164:
160:
156:
152:
38:Escitalopram
33:
10666:Venlafaxine
10646:Remoxipride
10636:Propranolol
10561:Cinnarizine
10461:Lamotrigine
10357:Pentazocine
10352:Noribogaine
10342:Nemonapride
10174:Haloperidol
10100:Spipethiane
10065:Noribogaine
10060:Nemonapride
10055:KCR-12-83.1
9895:Pentazocine
9855:Haloperidol
9760:Pridopidine
9735:Pentazocine
9652:Fluvoxamine
9572:Cyclazocine
9409:Adrenergics
9336:Valbenazine
9326:Rose bengal
9271:Deserpidine
9242:amphetamine
9192:levorphanol
9136:Dextrorphan
9089:ziprasidone
9071:pheniramine
9006:Lofepramine
8986:Desipramine
8935:Tesofensine
8925:Sibutramine
8900:Perafensine
8860:JNJ-7925476
8855:Indatraline
8800:Dasotraline
8770:Amifitadine
8749:Venlafaxine
8729:Milnacipran
8628:Etoperidone
8608:Seproxetine
8598:Pirandamine
8578:Omiloxetine
8558:Fluvoxamine
8518:Cericlamine
8508:Alaproclate
8455:levorphanol
8384:ziprasidone
8366:pheniramine
8338:Setiptiline
8323:Maprotiline
8282:Lofepramine
8262:Desipramine
8211:Tesofensine
8201:Sibutramine
8176:Perafensine
8136:JNJ-7925476
8131:Indatraline
8076:Dasotraline
8046:Amifitadine
8025:Venlafaxine
8000:Milnacipran
7929:Nomifensine
7894:Fencamfamin
7823:Lortalamine
7813:Edivoxetine
7803:Ciclazindol
7798:Alseroxylon
7746:Venlafaxine
7726:Tametraline
7716:Sibutramine
7691:Perafensine
7671:Nomifensine
7601:Indatraline
7576:Fencamfamin
7551:DOV-216,303
7546:DOV-102,677
7506:Dasotraline
7501:Ciclazindol
7459:Armodafinil
7454:Amifitadine
7403:Tesofensine
7211:Difemetorex
7056:risperidone
7034:haloperidol
6998:venlafaxine
6975:fluvoxamine
6877:from market
6806:Mepiprazole
6791:Hydroxyzine
6781:Cycloserine
6759:propranolol
6701:Flupentixol
6658:Agomelatine
6636:mirtazapine
6457:meprobamate
6391:Fludiazepam
6366:Clotiazepam
6361:Clorazepate
6242:Anxiolytics
6184:from market
6127:brexanolone
6041:risperidone
5938:Moclobemide
5920:Reversible:
5880:Reversible:
5803:Iproclozide
5738:Setiptiline
5733:Mirtazapine
5723:Maprotiline
5680:Propizepine
5665:Noxiptiline
5650:Metapramine
5640:Lofepramine
5610:Dimetacrine
5600:Desipramine
5473:Flupentixol
5458:Etryptamine
5443:Amisulpride
5438:Agomelatine
5384:Etoperidone
5361:Setiptiline
5356:Mirtazapine
5328:Nomifensine
5285:Atomoxetine
5262:Venlafaxine
5252:Milnacipran
5194:Fluvoxamine
5066:22 November
4867:Miranda H.
4675:(1): 1–13.
3758:27 November
3725:27 November
3695:27 November
2920:L'Encéphale
2453:13 February
2423:31 December
2393:28 December
2244:6 September
2207:31 December
1999:Brand names
1888:selectivity
1660:antibiotics
1649:mizolastine
1613:supplements
1543:fluvoxamine
1500:desipramine
1496:peak levels
1476:risperidone
1429:. However,
1427:tachycardia
1143:venlafaxine
1118:QT interval
1107:suicidality
1019:agoraphobia
1013:(OCD), and
799: g·mol
742:100.244.188
672:CHEBI:36791
547:128196-01-0
508:Identifiers
461:Metabolites
191:MedlinePlus
148:Other names
139:Trade names
21:left handed
10717:Categories
10651:SL 82.0715
10566:Cinuperone
10541:Caramiphen
10536:Butaclamol
10436:Tapentadol
10367:Safinamide
10347:Nepinalone
10312:Clemastine
10307:5-MeO-DiPT
10302:5-MeO-DALT
10179:Ifenprodil
10144:Arketamine
10095:Selegiline
10090:Safinamide
10050:Imipramine
10012:Clorgiline
10002:Clemastine
9992:Azidopamil
9982:5-MeO-DiPT
9977:5-MeO-DALT
9910:Sertraline
9710:Nepinalone
9657:Ifenprodil
9647:Fluoxetine
9612:Dimemorfan
9581:prasterone
9542:Citalopram
9537:Captodiame
9517:Arketamine
9512:Amantadine
9470:modulators
9385:SoRI-20041
9378:SoRI-20040
9306:Ketanserin
9233:Amiodarone
9196:tapentadol
9156:Mesembrine
9126:Delucemine
9103:esketamine
9016:Pipofezine
9001:Imipramine
8920:SEP-228432
8915:SEP-228431
8885:Nefazodone
8870:Liafensine
8840:Fezolamine
8830:DOV-216303
8825:DOV-102677
8780:Bicifadine
8775:Ansofaxine
8714:Eclanamine
8709:Duloxetine
8694:Bicifadine
8668:Vilazodone
8638:Lubazodone
8633:Litoxetine
8618:Zimelidine
8613:Sertraline
8588:Paroxetine
8583:Panuramine
8553:Fluoxetine
8548:Femoxetine
8528:Dapoxetine
8523:Citalopram
8447:tapentadol
8426:Nefazodone
8409:Ephenidine
8404:Dopexamine
8287:Melitracen
8277:Imipramine
8196:SEP-228432
8191:SEP-228431
8161:Nefazodone
8146:Liafensine
8116:Fezolamine
8106:DOV-216303
8101:DOV-102677
8056:Bicifadine
8051:Ansofaxine
8010:Nafenodone
7985:Eclanamine
7980:Duloxetine
7939:Radafaxine
7919:Manifaxine
7904:Lefetamine
7879:Amineptine
7863:Viloxazine
7838:Reboxetine
7833:Nisoxetine
7711:Sertraline
7701:Radafaxine
7686:Oroxylin A
7631:Manifaxine
7621:Liafensine
7611:Lefetamine
7591:GYKI-52895
7581:Fezolamine
7566:Esketamine
7561:Ephenidine
7484:BTS 74,398
7474:Ansofaxine
7469:Amineptine
7348:FP-β-CPPIT
7343:FE-β-CPPIT
7282:Prolintane
7175:Vanoxerine
7170:Nefazodone
7052:quetiapine
7048:olanzapine
6983:sertraline
6979:paroxetine
6971:fluoxetine
6963:citalopram
6821:Oxaflozane
6749:guanfacine
6696:Quetiapine
6673:Vilazodone
6668:Tianeptine
6651:phenelzine
6591:duloxetine
6549:Pregabalin
6534:Gabapentin
6453:Carbamates
6416:Nordazepam
6371:Cloxazolam
6356:Clonazepam
6336:Bromazepam
6331:Alprazolam
6326:Adinazolam
6159:Tryptophan
6131:zuranolone
6037:quetiapine
6033:olanzapine
6029:lurasidone
5983:Selegiline
5973:-selective
5953:Toloxatone
5948:Tetrindole
5943:Pirlindole
5923:Eprobemide
5913:-selective
5893:Bifemelane
5883:Caroxazone
5843:Phenelzine
5828:Mebanazine
5808:Iproniazid
5695:Tianeptine
5675:Pipofezine
5645:Melitracen
5625:Imipramine
5605:Dibenzepin
5565:Amineptine
5513:Tianeptine
5498:Pivagabine
5493:Oxaflozane
5453:Esketamine
5417:Vilazodone
5389:Nefazodone
5318:Amineptine
5295:Viloxazine
5290:Reboxetine
5242:Duloxetine
5214:Zimelidine
5209:Sertraline
5204:Paroxetine
5189:Fluoxetine
5179:Citalopram
4936:19 January
4910:10 October
4883:10 October
4852:17 October
4448:"UpToDate"
3643:(4): E11.
2118:22 October
2058:References
1988:citalopram
1952:citalopram
1945:enantiomer
1820:>1,000
1807:>1,000
1768:>1,000
1755:>1,000
1680:saquinavir
1645:astemizole
1539:fluoxetine
1535:citalopram
1531:omeprazole
1504:metoprolol
1435:hypertonia
1431:dyskinesia
1373:brain zaps
1366:withdrawal
1244:Arthralgia
1236:Anorgasmia
1231:Anisocoria
1184:citalopram
1135:citalopram
1114:Citalopram
1096:anorgasmia
1025:Depression
975:citalopram
956:citalopram
952:enantiomer
835:enantiomer
804:3D model (
792:Molar mass
692:ChEMBL1508
632:4O4S742ANY
603:ChemSpider
538:CAS Number
517:IUPAC name
436:Metabolism
275:Drug class
29:citalopram
27:form, see
10678:See also:
10656:SR-31747A
10641:Quinidine
10626:Proadifen
10611:Molindone
10586:Hypericin
10581:EMD-59983
10531:BMY-13980
10516:SKF-83959
10431:Naluzotan
10411:Berberine
10408:Agonists:
10362:RS-67,333
10297:4-MeO-PCP
10292:3-MeO-PCE
10207:Opipramol
10202:OPC-14523
10136:Agonists:
10075:RS-67,333
10020:-Deprenyl
9972:4-MeO-PCP
9952:3-MeO-PCP
9937:SOMCL-668
9929:Positive:
9925:Phenytoin
9915:SR-31742A
9890:PD-144418
9880:NPC-16377
9730:Opipramol
9725:OPC-14523
9720:Noscapine
9690:Memantine
9632:Eliprodil
9627:Donepezil
9502:5-MeO-DMT
9489:Agonists:
9398:See also:
9373:SoRI-9804
9321:Reserpine
9291:GBR-12935
9286:Efavirenz
9206:Roxindole
9184:methadone
9171:N-Me-5-HT
9141:Efavirenz
9099:3-MeO-PCP
9042:Amoxapine
8910:Pridefine
8880:Naphyrone
8744:Tofenacin
8663:Trazodone
8653:SB-649915
8648:Quipazine
8643:LY-393558
8568:Ifoxetine
8563:Indalpine
8439:methadone
8328:Mianserin
8318:Amoxapine
8186:Pridefine
8156:Naphyrone
8020:Tofenacin
7970:CP-39,332
7889:Fencamine
7884:Bupropion
7853:Tandamine
7848:Talsupram
7808:Daledalin
7706:Rimcazole
7696:Pridefine
7661:Modafinil
7586:Fluorenol
7556:Efavirenz
7489:Bupropion
7449:Adrafinil
7413:Tropoxane
7303:Altropane
7300:Tropanes:
7277:Naphyrone
7241:Pipradrol
7160:GBR-13098
7155:GBR-13069
7150:GBR-12935
7145:GBR-12783
6887:Phase III
6875:Withdrawn
6856:Validolum
6851:Tofisopam
6846:Tiagabine
6836:Picamilon
6816:Opipramol
6741:clonidine
6663:Bupropion
6606:trazodone
6496:Zopiclone
6488:Hypnotics
6478:Etifoxine
6426:Pinazepam
6411:Medazepam
6406:Lorazepam
6401:Ketazolam
6396:Halazepam
6341:Camazepam
6275:Buspirone
6194:Phase III
6182:Withdrawn
6047:Buspirone
5933:Minaprine
5868:Tedizolid
5863:Safrazine
5838:Octamoxin
5833:Nialamide
5823:Linezolid
5818:Isoniazid
5728:Mianserin
5670:Opipramol
5635:Iprindole
5615:Dosulepin
5580:Amoxapine
5536:Tricyclic
5394:Trazodone
5351:Mianserin
5323:Bupropion
5257:Tofenacin
5199:Indalpine
5148:Specific
4462:10 August
4350:Drugs.com
3844:0098-7484
3222:23 August
2748:241309451
2536:30 August
2511:30 August
2413:Drugs.com
2039:kickbacks
1935:Chemistry
1925:quinidine
1921:verapamil
1877:receptors
1865:serotonin
1853:2,600 (IC
1684:lopinavir
1676:ritonavir
1653:macrolide
1609:vitamin E
1585:ibuprofen
1566:linezolid
1547:Bupropion
1408:Pregnancy
1402:anhedonia
1389:akathisia
1377:dizziness
1319:Sinusitis
1284:Impotence
1271:Dry mouth
1266:Dizziness
1224:Abnormal
1058:as well.
940:pregnancy
827:Chirality
492:Excretion
481:half-life
261:Routes of
235:Pregnancy
183:Monograph
177:Drugs.com
10758:Nitriles
10707:Medicine
10621:Pimozide
10576:Dezocine
10466:Naloxone
10426:Metaphit
10421:Fourphit
10401:Unsorted
10337:Ibogaine
10277:SAS-0132
10227:UKH-1114
10184:Ketamine
10169:DKR-1051
10164:DKR-1005
10045:Ibogaine
9677:L-687384
9672:Ketamine
9360:Luteolin
9311:Lobeline
9301:Ibogaine
9200:tramadol
9146:Hypidone
9107:ketamine
9085:loxapine
8945:Tropanes
8875:Mazindol
8865:JZ-IV-10
8699:CP-39332
8658:TGBA01AD
8451:tramadol
8394:ketamine
8380:loxapine
8221:Tropanes
8151:Mazindol
8141:JZ-IV-10
7843:Talopram
7828:Mazindol
7793:Amedalin
7651:Metaphit
7646:Mesocarb
7636:Mazindol
7606:Ketamine
7408:Troparil
7165:JJC8-088
6831:Phenibut
6811:Nicotine
6731:prazosin
6544:Phenibut
6524:blockers
6431:Prazepam
6421:Oxazepam
6386:Etizolam
6376:Diazepam
6351:Clobazam
6280:Gepirone
6267:agonists
6120:GABAkine
5798:Benmoxin
5754:Tiazesim
5478:Ketamine
5463:Gepirone
5060:Archived
4930:Archived
4904:Archived
4877:Archived
4813:Archived
4777:23670590
4725:16448580
4689:21901317
4654:28153641
4605:28858536
4556:15062534
4548:24045971
4513:24424469
4456:Archived
4422:15784664
4360:22 April
4354:Archived
4329:16120067
4280:29063004
4272:19710642
4176:43329515
4168:26135630
4122:23446732
4086:28778697
4017:9 August
3993:45460237
3985:27171568
3950:18480703
3915:17183922
3880:21616541
3809:27303087
3752:Archived
3719:Archived
3689:Archived
3685:Medscape
3667:23791140
3618:19556032
3572:Archived
3547:32169926
3517:BMJ Open
3489:. US FDA
3469:23422053
3415:23360890
3391:: f288.
3366:17453659
3320:Archived
3283:Archived
3249:Archived
3213:Archived
3192:16430968
3157:23744611
3108:26971233
3067:19961809
3031:72332967
3023:30712879
2984:43179425
2976:21034375
2940:22381728
2905:22786497
2856:22876296
2816:PLOS ONE
2797:32394557
2717:29477251
2640:15 March
2634:Archived
2610:15 March
2604:Archived
2580:15 March
2574:Archived
2531:ClinCalc
2505:Archived
2501:ClinCalc
2471:(2023).
2447:Archived
2445:. 2015.
2417:Archived
2387:Archived
2352:17375980
2298:24289655
2235:Archived
2201:DailyMed
2178:3 August
2172:Archived
2144:30 March
2089:25 April
2046:See also
1980:Lundbeck
1972:Lundbeck
1949:racemate
1890:for the
1869:reuptake
1722:0.8–1.1
1589:naproxen
1488:tramadol
1480:tramadol
1456:racemate
1421:Overdose
1369:symptoms
1329:Vomiting
1258:Diarrhea
960:racemate
926:. It is
908:Cipralex
890:(verify)
583:DrugBank
346:Class C1
288:ATC code
268:By mouth
237:category
219:DailyMed
10491:UMB-116
10486:UMB-103
10481:UMB-101
10476:UMB-100
10267:MIN-101
10257:CT-1812
10247:BD-1067
10242:BD-1008
10149:BD-1047
10085:Saffron
10070:RHL-033
9840:Dup-734
9825:BD-1067
9820:BD-1063
9815:BD-1060
9810:BD-1047
9805:BD-1031
9800:BD-1008
9745:PRE-084
9562:Cocaine
9527:BD-1052
9296:GZ-793A
9240:(e.g.,
9178:(e.g.,
9176:Opioids
9097:(e.g.,
9083:(e.g.,
9049:(e.g.,
9037:A-80426
9034:Others:
8996:Doxepin
8949:cocaine
8947:(e.g.,
8895:NS-2359
8890:Nefopam
8845:HDMP-28
8835:EXP-561
8795:Cocaine
8724:McN5652
8603:RTI-353
8433:(e.g.,
8431:Opioids
8392:(e.g.,
8378:(e.g.,
8356:(e.g.,
8351:Others:
8272:Doxepin
8225:cocaine
8223:(e.g.,
8171:NS-2359
8166:Nefopam
8121:HDMP-28
8111:EXP-561
8071:Cocaine
7995:McN5652
7914:LR-5182
7676:NS-2359
7666:Nefopam
7626:LR-5182
7571:EXP-561
7446:Others:
7398:RTI-336
7393:RTI-229
7388:RTI-177
7383:RTI-150
7378:RTI-126
7373:RTI-121
7368:RTI-113
7363:RTI-112
7323:Cocaine
7221:HDMP-28
7140:DBL-583
6801:Mebicar
6757:(e.g.,
6739:(e.g.,
6729:(e.g.,
6655:Others:
6649:(e.g.,
6634:(e.g.,
6619:(e.g.,
6604:(e.g.,
6589:(e.g.,
6574:(e.g.,
6455:(e.g.,
6445:(e.g.,
6438:Alpidem
6435:Others:
6052:Lithium
5620:Doxepin
5152:and/or
4822:7 April
4768:3773671
4645:5410405
4596:5606297
4504:4047306
4320:1884771
4211:8953171
4130:2065578
4041:446–449
3800:4896342
3658:3692726
3578:5 March
3538:7069257
3460:3581598
3406:3558546
3148:7073417
2896:4204633
2847:3410906
2824:Bibcode
2788:7215080
2708:5889788
2600:Reuters
1962:History
1742:27,400
1662:, some
1639:, some
1558:ginseng
1520:CYP2C19
1484:codeine
1332:Yawning
1310:(fever)
1308:Pyrexia
1296:Myalgia
1292:changes
1280:Fatigue
1240:Anxiety
1156:sotalol
1009:(SAD),
1005:(GAD),
932:oxalate
914:of the
904:Lexapro
797:324.399
759:Formula
592:DB01175
558:PubChem
503:(minor)
445:CYP2C19
387:Rx-only
384:WARNING
356::
304:)
298: (
296:N06AB10
250: C
221::
197:a603005
25:racemic
10693:Portal
10506:YZ-185
10501:YZ-069
10496:YZ-011
10387:UMB-82
10382:UMB-23
10262:LR-172
10252:CM-156
10237:AC-927
10154:BD1063
10115:YKP10A
10080:RTI-55
9967:4-IPBS
9957:4C-T-2
9875:NE-100
9870:MS-377
9865:LR-172
9860:LR-132
9845:E-5842
9835:CM-156
9795:AC-927
9780:UMB-82
9775:UMB-23
9522:BD-737
9497:4-PPBP
9350:Others
8905:PRC200
8850:HP-505
8593:PIM-35
8181:PRC200
8126:HP-505
7934:O-2172
7681:O-2172
7358:RTI-55
7023:Others
6870:WHO-EM
6841:Selank
6769:Others
6177:WHO-EM
5890:Mixed:
5747:Others
5431:Others
5339:NaSSAs
4775:
4765:
4723:
4687:
4652:
4642:
4603:
4593:
4554:
4546:
4511:
4501:
4420:
4383:
4327:
4317:
4278:
4270:
4232:
4209:
4174:
4166:
4128:
4120:
4084:
4047:
3991:
3983:
3948:
3913:
3878:
3842:
3807:
3797:
3665:
3655:
3616:
3545:
3535:
3467:
3457:
3413:
3403:
3364:
3255:13 May
3190:
3155:
3145:
3106:
3065:
3029:
3021:
3003:Lancet
2982:
2974:
2938:
2903:
2893:
2854:
2844:
2795:
2785:
2746:
2715:
2705:
2687:Lancet
2350:
2296:
2160:Anvisa
1843:1,240
1833:2,000
1794:3,900
1781:2,500
1732:7,800
1581:NSAIDs
1524:CYP2E1
1516:CYP2C9
1512:CYP1A2
1508:CYP3A4
1492:
1468:CYP2D6
1444:plasma
1439:clonus
1437:, and
1325:Tremor
1290:Libido
1226:dreams
1173:, and
1094:, and
1088:libido
1074:only.
983:
845:SMILES
683:ChEMBL
652:D07913
612:129277
572:146570
453:CYP2D6
449:CYP3A4
381:
368:
358:℞-only
344:
331:
282:(SSRI)
217:
133:
10471:SM-21
10212:PB-28
10139:3-PPP
9962:4-IBP
9790:3-PPP
9492:3-PPP
9221:VMATs
7433:WF-33
7428:WF-31
7423:WF-23
7418:WF-11
6990:SNRIs
6955:SSRIs
6643:MAOIs
6628:TeCAs
6598:SARIs
6583:SNRIs
6568:SSRIs
6147:5-HTP
5711:TeCAs
5372:SARIs
5306:NDRIs
5225:SNRIs
5167:SSRIs
4991:(PDF)
4980:(PDF)
4873:WebMD
4816:(PDF)
4809:(PDF)
4552:S2CID
4276:S2CID
4172:S2CID
4126:S2CID
3989:S2CID
3744:(PDF)
3493:1 May
3323:(PDF)
3312:(PDF)
3286:(PDF)
3275:(PDF)
3216:(PDF)
3209:(PDF)
3027:S2CID
2980:S2CID
2744:S2CID
2238:(PDF)
2227:(PDF)
1712:(nM)
1705:Site
1574:MAOIs
1537:with
1522:, or
1448:serum
1084:SSRIs
1062:Other
865:InChI
806:JSmol
663:ChEBI
501:feces
497:Urine
441:Liver
10456:AZ66
10451:AHD1
10392:W-18
10318:DiPT
10190:MDMA
10110:W-18
10026:DiPT
9683:MDMA
9667:IPAB
9548:CGRP
9261:AZIK
9250:MDMA
8739:PPPA
8482:SRIs
8471:SERT
8015:PPPA
7772:NRIs
7272:MDPV
7119:DRIs
7005:TCAs
6613:TCAs
6520:VDCC
6308:PAMs
6296:GABA
6256:5-HT
6246:N05B
6113:SAMe
5553:TCAs
5538:and
5273:NRIs
5135:N06A
5068:2020
4938:2009
4912:2007
4885:2007
4854:2020
4824:2007
4773:PMID
4721:PMID
4685:PMID
4650:PMID
4601:PMID
4544:PMID
4509:PMID
4464:2022
4418:PMID
4381:ISBN
4362:2018
4325:PMID
4268:PMID
4230:ISBN
4207:PMID
4164:PMID
4118:PMID
4082:PMID
4045:ISBN
4019:2015
3981:PMID
3946:PMID
3911:PMID
3876:PMID
3840:ISSN
3824:JAMA
3805:PMID
3760:2013
3727:2013
3697:2013
3663:PMID
3614:PMID
3580:2013
3543:PMID
3495:2024
3465:PMID
3411:PMID
3362:PMID
3331:2007
3294:2007
3257:2007
3224:2017
3188:PMID
3153:PMID
3131:2013
3104:PMID
3063:PMID
3019:PMID
2972:PMID
2936:PMID
2901:PMID
2879:2012
2852:PMID
2793:PMID
2713:PMID
2642:2020
2612:2020
2582:2020
2538:2024
2513:2024
2455:2018
2425:2017
2395:2017
2348:PMID
2294:PMID
2246:2022
2209:2023
2180:2023
2146:2024
2120:2023
2091:2015
2015:Teva
1982:and
1923:and
1873:5-HT
1849:hERG
1839:mACh
1774:5-HT
1761:5-HT
1748:5-HT
1718:SERT
1664:5-HT
1655:and
1145:and
922:and
906:and
643:KEGG
623:UNII
420:~80%
410:data
173:AHFS
10373:TMA
10328:DPT
10036:DPT
9256:APP
7761:NET
7479:BTQ
7318:CFT
7108:DAT
6936:OCD
6653:);
6076:),
5964:MAO
5904:MAO
5405:SMS
4763:PMC
4755:doi
4713:doi
4677:doi
4673:219
4640:PMC
4632:doi
4591:PMC
4583:doi
4536:doi
4532:387
4499:PMC
4491:doi
4410:doi
4406:352
4315:PMC
4307:doi
4260:doi
4199:doi
4195:685
4156:doi
4110:doi
4074:doi
3973:doi
3938:doi
3903:doi
3868:doi
3864:134
3832:doi
3828:301
3795:PMC
3787:doi
3653:PMC
3645:doi
3606:doi
3533:PMC
3525:doi
3455:PMC
3447:doi
3401:PMC
3393:doi
3389:346
3385:BMJ
3354:doi
3180:doi
3143:PMC
3135:doi
3094:doi
3055:doi
3011:doi
3007:393
2964:doi
2928:doi
2891:PMC
2883:doi
2842:PMC
2832:doi
2783:PMC
2775:doi
2736:doi
2703:PMC
2695:doi
2691:391
2664:doi
2564:doi
2477:hdl
2443:NHS
2383:"X"
2340:doi
2286:doi
2113:FDA
1738:DAT
1728:NET
1686:).
1651:),
1595:),
1541:or
1446:or
1167:ECG
1128:(a
954:of
942:or
708:EPA
562:CID
370:POM
301:WHO
10719::
9927:;
9423:•
9419:•
9415:•
9411:•
9407:•
9403:•
9380:;
9248:,
9244:,
9198:,
9194:,
9190:,
9186:,
9182:,
9113:,
9109:,
9105:,
9101:,
9087:,
9073:,
9069:,
9065:,
9061:,
9057:,
9053:,
8453:,
8449:,
8445:,
8441:,
8437:,
8396:,
8382:,
8368:,
8364:,
8360:,
7054:,
7050:,
7046:,
6981:,
6977:,
6973:,
6969:,
6965:,
6883::
6747:,
6743:,
6433:;
6258:1A
6190::
6129:,
6084:))
6080:(T
6072:(T
6058:,
6039:,
6035:,
6031:,
6027:,
6023:,
5089:.
5054:.
5032:.
5008:.
4982:.
4955:.
4875:.
4871:.
4840:.
4771:.
4761:.
4751:38
4749:.
4745:.
4733:^
4719:.
4709:10
4707:.
4683:.
4671:.
4648:.
4638:.
4626:.
4622:.
4599:.
4589:.
4579:31
4577:.
4573:.
4550:.
4542:.
4530:.
4507:.
4497:.
4487:29
4485:.
4481:.
4454:.
4450:.
4430:^
4416:.
4404:.
4352:.
4348:.
4337:^
4323:.
4313:.
4303:60
4301:.
4297:.
4274:.
4266:.
4256:86
4254:.
4205:.
4193:.
4170:.
4162:.
4152:11
4150:.
4138:^
4124:.
4116:.
4106:70
4104:.
4080:.
4068:.
4043:.
4027:^
3987:.
3979:.
3969:39
3967:.
3944:.
3934:28
3932:.
3909:.
3899:77
3897:.
3874:.
3862:.
3838:.
3826:.
3803:.
3793:.
3783:51
3781:.
3777:.
3746:.
3713:.
3687:.
3683:.
3661:.
3651:.
3641:38
3639:.
3635:.
3612:.
3602:54
3600:.
3588:^
3566:.
3555:^
3541:.
3531:.
3521:10
3519:.
3515:.
3503:^
3471:.
3463:.
3453:.
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