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Disease outbreak

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hygiene and hand-washing is one of the first things recommended. Other interventions may be added as the investigation moves forward and more information is obtained. Waiting until the end of an investigation to implement prevention and control measures is a sure way to lose ones job. In outbreaks identified through notifiable disease surveillance, reports are often linked to laboratory results and verifying the diagnosis is straight forward. In outbreaks of unknown etiology, determining and verifying the diagnosis can be a significant part of the investigation with respect to time and resources. Several steps are usually going on at any point in time during the investigation. Steps may be repeated. For example, initial case definitions are often established to be intentionally broad but later refined as more is learned about the outbreak. The above list has 9 steps, others have more. Implementing active surveillance to identify additional cases is often added.
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when cases are in excess of normal expectancy for the location or season. It may affect a small and localized group or impact upon thousands of people across an entire continent. The number of cases varies according to the disease-causing agent, and the size and type of previous and existing exposure
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The order of the above steps and relative amount of effort and resources used in each varies from outbreak to outbreak. For example, prevention and control measures are usually implemented very early in the investigation, often before the causative agent is known. In many situations, promoting good
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of the infectious disease has elapsed without identification of any new case, however, for organisms with a short incubation period (e.g. fewer than ten days), a period of three times the incubation period is preferred.
228:– a communicable disease, such as influenza, measles, mumps, pneumonia, colds, viruses, and smallpox, which is characteristic of a particular place, or among a particular group, or area of interest or activity. 234:– when this disease is found to infect a significantly larger number of people at the same time than is common at that time, and among that population, and may spread through one or several communities. 262:
Outbreak legislation is still in its infancy and not many countries have had a direct and complete set of the provisions. However, some countries do manage the outbreaks using relevant acts, such as
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The terms "outbreak" and "epidemic" have often been used interchangeably. Researchers Manfred S. Green and colleagues propose that the latter term be restricted to larger events, pointing out that
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There are several outbreak patterns, which can be useful in identifying the transmission method or source, and predicting the future rate of infection. Each has a distinctive
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When investigating disease outbreaks, the epidemiology profession has developed a number of widely accepted steps. As described by the United States
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Outbreak debriefing and review has also been recognized as an additional final step and iterative process by the Public Health Agency of Canada.
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Identify the existence of the outbreak (Is the group of ill persons normal for the time of year, geographic area, etc.?)
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Common source – All victims acquire the infection from the same source (e.g. a contaminated water supply).
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Continuous source – Common source outbreak where the exposure occurs over multiple incubation periods
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Point source – Common source outbreak where the exposure occurs in less than one incubation period
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By convention, a communicable disease outbreak is declared over when a period of twice the
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Ghebrehewet S, Stewart AG, Baxter D, Shears P, Conrad D, Kliner M, eds. (October 2016).
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Perrocheau A, Jephcott F, Asgari-Jirhanden N, Greig J, Peyraud N, Tempowski J (2023).
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are near-global disease outbreaks when multiple and various countries around the
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Green MS, Swartz T, Mayshar E, Lev B, Leventhal A, Slater PE, Shemer J (2002).
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to establish further legal obligations in managing disease outbreaks.
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Develop a hypothesis (What appears to be causing the outbreak?)
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International Treaty for Pandemic Preparedness and Response
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2019–present coronavirus pandemic by country and territory
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2014 Democratic Republic of the Congo Ebola virus outbreak
730:, audio hour on media coverage of outbreaks and epidemics 407:, EXCITE | Epidemiology in the Classroom | Outbreak Steps 195:
Propagated – Transmission occurs from person to person.
467:"Principles of Epidemiology in Public Health Practice" 611:. Vol. 1. Oxford University Press. p. 210. 370: 289: 153:
Develop and implement control and prevention systems
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Study hypotheses (collect data and perform analysis)
2877: 565:. Cdc.gov (2007-04-25). Retrieved on 2010-11-25. 553:. Cdc.gov (2007-04-25). Retrieved on 2010-11-25. 541:, Cdc.gov (2007-04-25). Retrieved on 2010-11-25. 711:"WHA to hold pandemic treaty talks in November" 21:"Outbreak" redirects here. For other uses, see 2466: 1115: 749: 665: 150:Refine hypothesis and carry out further study 240:– occurs when an epidemic spreads worldwide. 127:Verify the diagnosis related to the outbreak 16:Sudden increase in occurrences of a disease 2473: 2459: 756: 742: 474:Centers for Disease Control and Prevention 118:Centers for Disease Control and Prevention 442: 364: 103: 55:is a sudden increase in occurrences of a 245:Condition for Declaring an Outbreak Over 134:to define who/what is included as a case 107: 27: 1830:Ear-Nose-Throat/Upper respiratory tract 1003:Access to water, sanitation and hygiene 576:"Health Topic: Behavioral Risk Factors" 257: 156:Release findings to greater communities 2878: 2413:Infectious disease (medical specialty) 2305:Antimicrobial resistance surveillance 2454: 737: 327:1993 Four Corners hantavirus outbreak 141:as diagnosis is reported to insurance 137:Map the spread of the outbreak using 60:to the agent. Outbreaks include many 1660:Compartmental models in epidemiology 688:The State of Queensland Government. 659: 337:2007 Yap Islands Zika virus outbreak 322:1947 New York City smallpox outbreak 681: 668:"Outbreak actions protected by law" 13: 633: 617:10.1093/med/9780198745471.001.0001 405:Steps of an Outbreak Investigation 380:Israel Medical Association Journal 373:"When is an epidemic an epidemic?" 64:, which term is normally only for 14: 2902: 721: 690:"Legislation and Powers of Entry" 2409:Economics of Infectious Diseases 495:Public Health Agency of Canada. 306: 292: 272:International Health Regulations 703: 598: 568: 332:2003 Midwest monkeypox outbreak 270:member states are obligated by 203:Behavioral risk related (e.g., 180:of case infections and deaths. 120:, these include the following: 2418:Infectious disease informatics 2249:Transmission-based precautions 563:Glossary of Epidemiology Terms 556: 551:Glossary of Epidemiology Terms 544: 539:Glossary of Epidemiology Terms 532: 510: 488: 459: 410: 398: 100:acknowledge this distinction. 1: 1835:Chest/Lower respiratory tract 1610:Ocular (Eye) mucosal membrane 971:Behavioral/lifestyle factors 357: 205:sexually transmitted diseases 83: 32:Difference between outbreak, 2835:Potentially hazardous object 1397:Aerosol-generating procedure 1175:Silent/Subclinical infection 875:Multidrug-resistant bacteria 522:epiville.ccnmtl.columbia.edu 221:Patterns of occurrence are: 97:Stedman's Medical Dictionary 7: 2061:Vaccine-preventable disease 2009:Monoclonal antibody therapy 285: 91:Chambers Concise Dictionary 10: 2907: 2202:Respiratory source control 580:Center for Disease Control 20: 2827: 2790: 2749: 2731: 2700: 2693: 2661: 2627: 2620: 2598: 2568: 2534: 2501: 2492: 2392: 2346:Global Health Initiatives 2336:Evolutionary epidemiology 2284: 2076: 2031:Post-exposure prophylaxis 1967:Antimicrobial stewardship 1925: 1912: 1817: 1708: 1690:Multiplicity of infection 1655:Basic reproduction number 1630: 1602: 1588: 1574: 1558: 1526: 1488: 1431:Percutaneous inoculation 1417: 1379: 1372: 1354: 1286: 1253: 1246: 1210: 1203: 1106: 993: 915:Host–pathogen interaction 890: 784: 777: 435:10.1093/inthealth/ihac088 268:World Health Organization 23:Outbreak (disambiguation) 2164:Protective sequestration 2026:Pre-exposure prophylaxis 1317:Generational difference 870:Horizontal gene transfer 860:Antimicrobial resistance 207:, increased risk due to 167: 2351:Microbial phylogenetics 2269:Wastewater surveillance 1790:Geographic distribution 1665:Critical community size 1463:Surgical site infection 1311:Iatrogenic/Medical care 1230:Microbial translocation 1226:Endogenous reactivation 1221:Normal flora overgrowth 1170:Opportunistic infection 942:Opportunistic infection 518:"SARS Outbreak Study 2" 199:Outbreaks can also be: 2423:Microbial bioterrorism 2046:efficacy/effectiveness 1454:Surgical intervention 1346:Breakthrough infection 968:Genetic predisposition 952:Susceptible individual 799:Germ theory of disease 139:Information technology 113: 104:Outbreak investigation 44: 2259:Universal precautions 1217:Endogenous overgrowth 1069:Poultry and livestock 586:on September 28, 2008 111: 31: 2361:Genomic reassortment 2341:Genetic epidemiology 2180:Health communication 2108:Flattening the curve 2098:Disease surveillance 1881:Systemic/Generalized 1645:Animal disease model 1125:Asymptomatic carrier 423:International Health 352:Superspreading event 258:Outbreak legislation 2428:Pandemic prevention 2384:Viral phylodynamics 2365:Re-emerging disease 2254:Travel restrictions 1458:Postoperative wound 1427:Blood-borne disease 1409:Respiratory droplet 1321:Vertical/Congenital 1306:Nosocomial/Hospital 1263:Spillover infection 728:Plague of Suspicion 666:Star Publications. 80:are soon infected. 66:infectious diseases 2486:list by death toll 2374:Selection pressure 1670:Force of infection 1298:Contagious disease 1233:Endogenous seeding 1130:Chain of infection 1054:Injection drug use 965:Vaccination status 848:Case fatality rate 766:infectious disease 528:on March 19, 2009. 114: 45: 2891:Disease outbreaks 2873: 2872: 2850:Geomagnetic storm 2823: 2822: 2689: 2688: 2616: 2615: 2560:Soil liquefaction 2482:Natural disasters 2448: 2447: 2438:Tropical medicine 2379:Synthetic biology 2280: 2279: 2239:Social distancing 2192:Outbreak response 1813: 1812: 1640:Agent-based model 1626: 1625: 1622: 1621: 1618: 1617: 1165:Natural reservoir 1155:Infectious period 1145:Incubation period 1102: 1101: 1058:Natural disaster 1027:Tropical diseases 1010:Biodiversity loss 947:Risk of infection 937:Microbiome health 930:Immunosuppression 626:978-0-19-874547-1 608:Health Protection 264:public health law 251:incubation period 70:foodborne disease 2898: 2782:Tropical cyclone 2776:Tornado outbreak 2698: 2697: 2625: 2624: 2578:Pyroclastic flow 2570:Volcano eruption 2499: 2498: 2475: 2468: 2461: 2452: 2451: 2433:Tropical disease 2369:Reverse zoonosis 2356:One Health Model 2185:Health education 2174:Community health 2093:Cordon sanitaire 2066:Ring vaccination 2036:Repurposed drugs 1923: 1922: 1842:Gastrointestinal 1685:Machine learning 1489:Gastrointestinal 1440:Intravenous line 1377: 1376: 1291:/Cross-infection 1278:Reverse zoonosis 1251: 1250: 1208: 1207: 1113: 1112: 1094:War and conflict 962:Nutrition status 925:Immunodeficiency 782: 781: 758: 751: 744: 735: 734: 715: 714: 707: 701: 700: 698: 696: 685: 679: 678: 676: 674: 663: 657: 656: 654: 652: 643:. 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2603: 2601: 2597: 2591: 2588: 2584: 2581: 2580: 2579: 2576: 2575: 2573: 2571: 2567: 2561: 2558: 2556: 2553: 2551: 2548: 2547: 2545: 2542: 2537: 2533: 2527: 2524: 2522: 2519: 2517: 2514: 2512: 2509: 2508: 2506: 2504: 2500: 2497: 2495: 2491: 2487: 2483: 2476: 2471: 2469: 2464: 2462: 2457: 2456: 2453: 2439: 2436: 2435: 2434: 2431: 2429: 2426: 2424: 2421: 2419: 2416: 2414: 2411: 2408: 2406: 2403: 2401: 2398: 2397: 2395: 2391: 2385: 2382: 2380: 2377: 2375: 2372: 2370: 2367: 2364: 2362: 2359: 2357: 2354: 2352: 2349: 2347: 2344: 2342: 2339: 2337: 2334: 2332: 2329: 2327: 2324: 2322: 2319: 2317: 2314: 2310: 2307: 2306: 2304: 2302: 2299: 2297: 2294: 2293: 2291: 2289: 2283: 2272: 2270: 2267: 2265: 2262: 2260: 2257: 2255: 2252: 2250: 2247: 2245: 2244:Sterilization 2242: 2240: 2237: 2235: 2232: 2230: 2227: 2225: 2222: 2218: 2215: 2213: 2212:Surgical mask 2210: 2208: 2205: 2204: 2203: 2200: 2198: 2195: 2193: 2190: 2186: 2183: 2181: 2178: 2175: 2172: 2171: 2170: 2169:Public health 2167: 2165: 2162: 2158: 2155: 2154: 2153: 2150: 2148: 2145: 2141: 2138: 2137: 2136: 2133: 2129: 2126: 2124: 2121: 2119: 2116: 2115: 2114: 2111: 2109: 2106: 2104: 2101: 2099: 2096: 2094: 2091: 2089: 2086: 2085: 2083: 2081: 2075: 2067: 2064: 2062: 2059: 2057: 2054: 2052: 2049: 2047: 2044: 2043: 2042: 2039: 2037: 2034: 2032: 2029: 2027: 2024: 2022: 2021:Phage therapy 2019: 2017: 2014: 2010: 2007: 2006: 2005: 2004:Immunotherapy 2002: 2000: 1997: 1995: 1992: 1990: 1987: 1985: 1982: 1980: 1977: 1975: 1972: 1968: 1965: 1964: 1963: 1962:Antimicrobial 1960: 1956: 1953: 1952: 1951: 1948: 1946: 1943: 1939: 1936: 1935: 1934: 1931: 1930: 1928: 1924: 1921: 1919: 1911: 1904: 1902: 1899: 1897: 1894: 1892: 1889: 1887: 1884: 1882: 1879: 1876: 1874: 1871: 1869: 1866: 1863: 1861: 1858: 1855: 1853:Genitourinary 1852: 1848: 1845: 1844: 1843: 1840: 1836: 1833: 1831: 1828: 1827: 1825: 1824: 1822: 1816: 1806: 1803: 1801: 1798: 1796: 1793: 1791: 1788: 1786: 1783: 1781: 1778: 1776: 1773: 1771: 1768: 1766: 1763: 1761: 1758: 1756: 1753: 1751: 1748: 1746: 1743: 1739: 1736: 1734: 1731: 1730: 1729: 1726: 1724: 1721: 1719: 1716: 1715: 1713: 1711:in population 1707: 1701: 1698: 1696: 1693: 1691: 1688: 1686: 1683: 1681: 1678: 1676: 1675:Herd immunity 1673: 1671: 1668: 1666: 1663: 1661: 1658: 1656: 1653: 1651: 1648: 1646: 1643: 1641: 1638: 1637: 1635: 1633: 1629: 1611: 1608: 1607: 1605: 1601: 1594: 1593: 1591: 1587: 1580: 1579: 1577: 1573: 1567: 1564: 1563: 1561: 1559:Genitourinary 1557: 1551: 1547: 1545: 1542: 1540: 1537: 1535: 1532: 1531: 1529: 1525: 1519: 1516: 1514: 1511: 1509: 1506: 1502: 1501:Contamination 1499: 1498: 1497: 1494: 1493: 1491: 1487: 1479: 1476: 1474: 1471: 1470: 1469:Vector-borne 1468: 1464: 1461: 1459: 1456: 1455: 1453: 1449: 1446: 1443: 1441: 1438: 1436: 1433: 1432: 1430: 1428: 1425: 1424: 1422: 1416: 1410: 1407: 1405: 1402: 1398: 1395: 1394: 1393: 1390: 1388: 1385: 1384: 1382: 1378: 1375: 1371: 1365: 1362: 1361: 1359: 1353: 1347: 1344: 1340: 1337: 1333: 1330: 1327: 1324: 1323: 1322: 1319: 1318: 1316: 1312: 1309: 1307: 1304: 1303: 1301: 1299: 1296: 1295: 1293: 1289: 1285: 1279: 1276: 1274: 1271: 1269: 1266: 1264: 1261: 1260: 1258: 1256: 1255:Cross-species 1252: 1249: 1245: 1238: 1235: 1232: 1229: 1227: 1224: 1222: 1219: 1216: 1215: 1213: 1209: 1206: 1202: 1196: 1195:Window period 1193: 1191: 1188: 1186: 1183: 1181: 1178: 1176: 1173: 1171: 1168: 1166: 1163: 1161: 1160:Latent period 1158: 1156: 1153: 1151: 1148: 1146: 1143: 1141: 1138: 1136: 1133: 1131: 1128: 1126: 1123: 1122: 1120: 1114: 1111: 1109: 1105: 1095: 1092: 1090: 1087: 1085: 1082: 1080: 1077: 1075: 1072: 1070: 1067: 1063: 1060: 1059: 1057: 1055: 1052: 1050: 1047: 1045: 1042: 1040: 1039:Deforestation 1037: 1035: 1032: 1028: 1025: 1023: 1020: 1019: 1017: 1015: 1012: 1009: 1006: 1004: 1001: 1000: 998: 996: 992: 984:Stress levels 983: 980: 976: 973: 972: 970: 967: 964: 961: 958: 955: 954: 953: 950: 948: 945: 943: 940: 938: 935: 931: 928: 926: 923: 922: 921: 918: 916: 913: 911: 908: 906: 903: 901: 898: 897: 895: 893: 889: 883: 880: 876: 873: 871: 868: 866: 863: 862: 861: 858: 854: 851: 849: 846: 844: 841: 839: 836: 835: 834: 831: 829: 826: 822: 819: 818: 817: 816:Pathogenicity 814: 810: 807: 806: 805: 802: 800: 797: 795: 792: 791: 789: 787: 783: 780: 776: 771: 767: 759: 754: 752: 747: 745: 740: 739: 736: 729: 726: 725: 712: 706: 691: 684: 669: 662: 646: 642: 636: 628: 622: 618: 614: 610: 609: 601: 585: 581: 577: 571: 564: 559: 552: 547: 540: 535: 527: 523: 519: 513: 498: 491: 475: 468: 462: 454: 450: 445: 440: 436: 432: 428: 424: 420: 413: 406: 401: 393: 389: 385: 381: 374: 367: 363: 353: 350: 348: 345: 343: 340: 338: 335: 333: 330: 328: 325: 323: 320: 319: 315: 304: 301: 295: 290: 283: 281: 277: 273: 269: 265: 255: 252: 239: 236: 233: 230: 227: 224: 223: 222: 216: 213: 210: 206: 202: 201: 200: 194: 189: 186: 185: 183: 182: 181: 179: 175: 165: 162: 155: 152: 149: 146: 143: 140: 136: 133: 129: 126: 123: 122: 121: 119: 110: 101: 99: 98: 93: 92: 81: 79: 75: 71: 67: 63: 58: 54: 50: 43: 39: 35: 30: 24: 19: 2886:Epidemiology 2840:Impact event 2828:Astronomical 2762:Thunderstorm 2757:Bomb cyclone 2621:Hydrological 2590:Volcanic ash 2555:Seismic risk 2503:Mass wasting 2152:Notification 2123:Hand washing 2118:Food hygiene 2103:Disinfection 1999:Immunization 1950:Anthelmintic 1938:prophylactic 1826:Respiratory 1769: 1750:Hyperendemic 1700:WAIFW matrix 1355:Environment- 1108:Transmission 1084:Urbanization 882:Host tropism 778:Determinants 764:Concepts in 705: 693:. Retrieved 683: 671:. Retrieved 661: 649:. Retrieved 645:the original 635: 607: 600: 588:. Retrieved 584:the original 579: 570: 558: 546: 534: 526:the original 521: 512: 500:. Retrieved 490: 478:. Retrieved 473: 461: 426: 422: 412: 400: 383: 379: 366: 261: 248: 220: 209:malnutrition 198: 171: 163: 159: 115: 95: 89: 87: 52: 49:epidemiology 46: 18: 2855:Solar flare 2741:Megadrought 2701:Temperature 2674:Megatsunami 2653:Storm surge 2648:Flash flood 2526:Debris flow 2405:Eradication 2316:Biosecurity 2041:Vaccination 2016:Inoculation 1994:Drug safety 1989:Combination 1916:and Control 1864:Soft tissue 1818:Anatomical 1785:Seasonality 1765:Mesoendemic 1745:Holoendemic 1738:Farr's laws 1650:Attack rate 1448:Animal bite 1444:Insect bite 1380:Respiratory 1007:Air quality 995:Environment 905:Comorbidity 821:Attack rate 804:Infectivity 2880:Categories 2536:Earthquake 2494:Geological 2288:infections 2229:Sanitation 2197:Quarantine 2056:resistance 1974:Antiseptic 1955:Ascaricide 1945:Antifungal 1933:Antibiotic 1914:Prevention 1847:Intestinal 1780:Prevalence 1760:Inequality 1709:Occurrence 1508:Breastmilk 1392:Bioaerosol 1364:Sapronosis 1339:Horizontal 1211:Endogenous 1190:Viral load 1150:Index case 386:(1): 3–6. 358:References 84:Definition 2865:Hypernova 2860:Supernova 2808:Firestorm 2723:Heat wave 2718:Ice storm 2713:Cold wave 2516:Avalanche 2511:Landslide 2400:Discovery 2326:Disease X 2286:Emerging 2234:Screening 2135:Isolation 1979:Antiviral 1805:Twindemic 1755:Incidence 1632:Modelling 1595:Perinatal 1527:Cutaneous 1418:Linked to 1328:Perinatal 1247:Exogenous 1239:formation 981:Pregnancy 838:Endotoxin 833:Virulence 178:histogram 130:Create a 74:Pandemics 62:epidemics 2815:ARkStorm 2803:Wildfire 2708:Blizzard 2608:Sinkhole 2309:EARS-Net 2224:Safe sex 2176:services 2147:Lockdown 1918:measures 1820:location 1800:Syndemic 1795:Sporadic 1775:Pandemic 1770:Outbreak 1728:Epidemic 1581:Prenatal 1473:Mosquito 1357:to-human 1332:Neonatal 1325:Prenatal 1273:Zoonosis 1118:concepts 1049:Humidity 1034:Commerce 910:Diabetes 843:Exotoxin 695:2 August 673:2 August 651:2 August 590:30 March 502:22 March 480:6 August 453:36630891 444:10472873 392:11802306 286:See also 238:Pandemic 232:Epidemic 215:Zoonotic 53:outbreak 42:pandemic 38:epidemic 2798:Derecho 2772:Tornado 2733:Drought 2669:Tsunami 2521:Mudflow 2113:Hygiene 2051:booster 1984:Asepsis 1723:Endemic 1718:Cluster 1302:Source 1237:Biofilm 1074:Poverty 1044:Ecology 1022:El Niño 975:Smoking 853:factors 794:Biofilm 770:Outline 226:Endemic 57:disease 34:endemic 2321:CRISPR 2273:Zoning 2128:Gloves 1539:Fomite 1373:Routes 1268:Vector 1135:Fomite 1116:Basic 1079:Travel 959:Gender 623:  451:  441:  390:  2791:Other 2662:Other 2629:Flood 2583:Lahar 2393:Other 1901:Fetus 1896:Mouth 1891:Tooth 1886:Blood 1873:Joint 1733:Curve 1603:Other 1550:wound 1548:Open 1518:Feces 1513:Water 1204:Modes 1062:Flood 786:Agent 476:. CDC 470:(PDF) 376:(PDF) 176:, or 168:Types 78:Earth 51:, an 2766:Hail 2634:List 2541:List 2157:list 2078:Non- 1868:Bone 1860:Skin 1544:Soil 1534:Burn 1496:Food 1478:Tick 1140:Host 900:Burn 892:Host 697:2008 675:2008 653:2008 621:ISBN 592:2020 504:2013 482:2016 449:PMID 388:PMID 94:and 40:and 2217:PPE 1905:Eye 1566:Sex 1387:Air 956:Age 613:doi 439:PMC 431:doi 274:to 47:In 2882:: 2484:– 619:. 578:. 520:. 472:. 447:. 437:. 425:. 421:. 382:. 378:. 266:. 36:, 2778:) 2774:( 2768:) 2764:( 2636:) 2632:( 2543:) 2539:( 2474:e 2467:t 2460:v 772:) 768:( 757:e 750:t 743:v 699:. 677:. 655:. 629:. 615:: 594:. 506:. 484:. 455:. 433:: 427:5 394:. 384:4 211:) 25:.

Index

Outbreak (disambiguation)

endemic
epidemic
pandemic
epidemiology
disease
epidemics
infectious diseases
foodborne disease
Pandemics
Earth
Chambers Concise Dictionary
Stedman's Medical Dictionary

Centers for Disease Control and Prevention
case definition
Information technology
epidemic curve
histogram
sexually transmitted diseases
malnutrition
Zoonotic
Endemic
Epidemic
Pandemic
incubation period
public health law
World Health Organization
International Health Regulations

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