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Department of Neurobiology, Harvard Medical School

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involvement in acceptance of medical students who were minorities
 it was something new, and it was a political struggle and that made it very interesting. I spent a lot of time there, time that I should have been spending in the lab doing science and research, on admissions and recruiting, and I got kind of devoted to that. I don’t regret that at all, it was an education for me."
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Early on, the founders of the Department worked to recruit students and researchers to work in their laboratories, and paid special attention to recruiting with a social conscience. According to David Potter, "There’s another fact of the department that interests me personally, has to do with our
116:, David Potter, and Edwin Furshpan to work on various aspects of nerve physiology. As Hubel later recounted, Wiesel, Hubel, and Kuffler "...represented central nervous system physiology; Furshpan and Potter (and of course Steve) represented synaptic physiology; and 175:
and Harvard Medical School, the Harvard Brain Initiative, co-chaired by Michael Greenberg and Joshua Sanes, funds collaborations and research initiatives specifically between members of the Department faculty and other neuroscientists at Harvard University.
127:. In 1966, Kuffler came up with the term neurobiology to unite these sub-disciplines into the first-ever Department of Neurobiology, an independent department at Harvard Medical School. Hubel later said, “I can’t be absolutely certain how the term 131:
originated, but I believe Steve Kuffler invented it when we had to think up a title for our department when it was founded on 1965. That he almost single-handedly invented the field of neurobiology, I think few would dispute.”
214:: Hubel and Wiesel discovered that experience can shape the brain’s circuitry, but only during early life, a period of time they call the ‘critical period’. This work in the visual cortex earned the duo the 151:
assumed the position of Department chair, a position he held until 2022. Under his leadership, he has integrated Harvard Neurobiology with neuroscience in the Harvard-affiliated hospitals, such as
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Wiltschko, Alexander B.; Johnson, Matthew J.; Iurilli, Giuliano; Peterson, Ralph E.; Katon, Jesse M.; Pashkovski, Stan L.; Abraira, Victoria E.; Adams, Ryan P.; Datta, Sandeep Robert (2015-12-16).
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Saunders, Arpiar; Oldenburg, Ian A.; Berezovskii, Vladimir K.; Johnson, Caroline A.; Kingery, Nathan D.; Elliott, Hunter L.; Xie, Tiao; Gerfen, Charles R.; Sabatini, Bernardo L. (2015-05-07).
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Giménez-Cassina, Alfredo; Martínez-François, Juan Ramón; Fisher, Jill K.; Szlyk, Benjamin; Polak, Klaudia; Wiwczar, Jessica; Tanner, Geoffrey R.; Lutas, Andrew; Yellen, Gary (2012-05-24).
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Filbin, Mariella Gruber; Dabral, Sukriti K.; Pazyra-Murphy, Maria F.; Ramkissoon, Shakti; Kung, Andrew L.; Pak, Ekaterina; Chung, Jarom; Theisen, Matthew A.; Sun, Yanping (2013-11-01).
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Gabel, Harrison W.; Kinde, Benyam Z.; Stroud, Hume; Gilbert, Caitlin S.; Harmin, David A.; Kastan, Nathaniel R.; Hemberg, Martin; Ebert, Daniel H.; Greenberg, Michael E. (2015-06-04).
99:“to understand the workings of the brain through basic research and to use that knowledge to work toward preventive and therapeutic methods that alleviate neurological diseases”. 1999: 434: 1827:
Binshtok, Alexander M.; Bean, Bruce P.; Woolf, Clifford J. (2007-10-04). "Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers".
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Kim, Tae-Kyung; Hemberg, Martin; Gray, Jesse M.; Costa, Allen M.; Bear, Daniel M.; Wu, Jing; Harmin, David A.; Laptewicz, Mike; Barbara-Haley, Kellie (2010-05-13).
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Kim, Tae-Kyung; Hemberg, Martin; Gray, Jesse M.; Costa, Allen M.; Bear, Daniel M.; Wu, Jing; Harmin, David A.; Laptewicz, Mike; Barbara-Haley, Kellie (2010-05-13).
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Wiesel, T. N.; Hubel, D. H. (1963-11-01). "Effects of Visual Deprivation on Morphology and Physiology of Cells in the Cat's Lateral Geniculate Body".
93:, with research pertaining to development of the nervous system, sensory neuroscience, neurophysiology, and behavior. The Department was founded by 795:
Kravitz, E. A.; Potter, D. D.; Van Gelder, N. M. (1962-04-28). "Gamma-aminobutyric acid and other blocking substances extracted from crab muscle".
419: 1211:"Probing the structure of the nicotinic acetylcholine receptor with 4-benzoylbenzoylcholine, a novel photoaffinity competitive antagonist" 1727:
Griffin, E. A.; Staknis, D.; Weitz, C. J. (1999-10-22). "Light-independent role of CRY1 and CRY2 in the mammalian circadian clock".
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Ben-Zvi, Ayal; Lacoste, Baptiste; Kur, Esther; Andreone, Benjamin J.; Mayshar, Yoav; Yan, Han; Gu, Chenghua (2014-05-22).
1672:"Inhibitory regulation of electrically-coupled neurons in the inferior olive is mediated by asynchronous release of GABA" 164: 644: 619: 546: 123:
The group moved to Harvard Medical School in 1959 as a sub-department within the Department of Pharmacology, headed by
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Activity-dependent transcription in neurons during development of neural circuits, and in neurodevelopmental disorders
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The Department's faculty also participates in the Program in Neuroscience PhD Program offered by Harvard University.
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Assad JA, Shepherd GM, Corey DP (1991). "Tip-link integrity and mechanical transduction in vertebrate hair cells".
156: 1466:"BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures" 562: 2004: 895:
Spiegel, I; Mardinly, AR; Gabel, HW; Bazinet, JE; Couch, CH; Tzeng, CP; Harmin, DA; Greenberg, ME (2014-05-22).
1772:"Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities" 897:"Npas4 regulates excitatory-inhibitory balance within neural circuits through cell type-specific gene programs" 160: 152: 182:
In October 2016, current and past faculty, students, and researchers will gather in Boston to celebrate the
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in 1966, the first department dedicated to Neurobiology in the world. The mission of the Department is
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Sabatini BL, Regehr WG (1996). "Timing of neurotransmission at fast synapses in the mammalian brain".
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Development of electrodes: Hubel developed an electrode for recording of single neurons in awake cats.
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Tsao, Doris Y.; Freiwald, Winrich A.; Tootell, Roger B. H.; Livingstone, Margaret S. (2006-02-03).
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Characterization and modulation of nicotinic acetylcholine receptors and discovery of rapsyn
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Woolf, CJ (1983). "Evidence for a central component of post-injury pain hypersensitivity".
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Hubel, D. H. (1957-03-22). "Tungsten Microelectrode for Recording from Single Units".
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Timing of neurotransmitter release from synapse and asynchronous release from synapses
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and close to 300 graduate students, post-doctoral fellows, and other research staff.
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Wiesel chaired the department from 1973, and was succeeded by David Potter in 1982,
1836: 1799: 1783: 1736: 1699: 1683: 1644: 1607: 1591: 1550: 1534: 1493: 1477: 1436: 1420: 1379: 1363: 1324: 1287: 1271: 1260:"Acetylcholine receptor-associated 43K protein contains covalently bound myristate" 1222: 1181: 1165: 1124: 1108: 1067: 1057: 1018: 981: 965: 924: 908: 867: 851: 804: 761: 718: 442: 140: 1740: 1687: 1595: 1481: 765: 465: 361: 203: 195:
Receptive fields in visual cortex: Pioneering work on the selective responses of
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Prior to moving to Boston, while at Johns Hopkins University, Kuffler recruited
954:"Disruption of DNA methylation-dependent long gene repression in Rett syndrome" 912: 505: 491: 480: 269: 144: 117: 113: 109: 1523:"MSFD2A is critical for the formation and function of the blood brain barrier" 1154:"Lateral presynaptic inhibition mediates gain control in an olfactory circuit" 324: 317: 281:
Real-time 3D imaging of mouse behavior to phenotype and analyze mouse behavior
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for their discoveries concerning information processing in the visual system
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50th Anniversary of the Department of Neurobiology, Harvard Medical School
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The Department’s current research generally encompasses the following
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Development of technologies to activate and monitor neuronal activity
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in 2000 (the first female to chair such a department). In 2008,
1577: 1097:"A Cortical Region Consisting Entirely of Face-Selective Cells" 1046:"Segregation of form, color, and stereopsis in primate area 18" 86: 65: 1094: 1209:
Wang, D.; Chiara, D. C.; Xie, Y.; Cohen, J. B. (2000-09-15).
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Select Awards and Honors for Past and Current Faculty Members
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Academic Department at Harvard University Medical School, USA
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Musil, LS; Carr, C; Cohen, JB; Merlie, JP (1988-09-01).
404:"for structural and mechanistic studies of ion channels" 243:
Cortical area specifically dedicated to face recognition
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Novel GABAergic pathway from basal ganglia to cortex
1726: 1406: 837: 2000:Neuroscience research centers in the United States 1970:Department of Neurobiology, Harvard Medical School 1314: 1208: 240:Processing of sub-modalities of vision in primates 179:David D. Ginty assumed the role of chair in 2022. 20:Department of Neurobiology, Harvard Medical School 1826: 1152:Olsen, Shawn R.; Wilson, Rachel I. (2008-04-24). 265:, RNA transcribed at enhancer sites in the genome 1991: 1943:"The Nobel Prize in Physiology or Medicine 2004" 1895:"The Nobel Prize in Physiology or Medicine 1981" 1580:"Mapping Sub-Second Structure in Mouse Behavior" 1043: 252:Molecular and biophysical analysis of auditory 1670:Best, Aaron R.; Regehr, Wade G. (2009-05-28). 1634: 461:2010: S. Robert Datta (current faculty member) 420:Albert Lasker Award for Basic Medical Research 246:Fundamental principles of olfactory processing 2010:Medical research institutes in Massachusetts 1151: 708: 1669: 451:2014: Chenghua Gu (current faculty member) 448:2012: Gary Yellen (current faculty member) 25: 1803: 1703: 1611: 1554: 1497: 1440: 1383: 1291: 1226: 1185: 1128: 1071: 1061: 985: 928: 871: 637:Steve: Remembrances of Stephen W. Kuffler 391:1981: Torsten N. Wiesel and David Hubel " 372:Regulation of sleep and circadian rhythms 634: 490:(current chair and faculty member) and 341:Sensory neuroscience and processing in 331:Development and plasticity of the brain 224:Kravitz, Potter, and colleagues define 1992: 356:Neurodevelopmental disorders, such as 1008: 751: 609: 536: 499:American Academy of Arts and Sciences 385:Nobel Prize in Physiology or Medicine 216:Nobel Prize in Physiology or Medicine 190:Notable Contributions to Neurobiology 456:NIH Director's New Innovator Awards: 1919:"The Nobel Prize in Chemistry 2003" 1215:The Journal of Biological Chemistry 494:(chair and faculty member, 2000–07) 312:Current Research and Academic Staff 186:of the founding of the Department. 165:Massachusetts Eye and Ear Infirmary 13: 1063:10.1523/JNEUROSCI.07-11-03378.1987 14: 2021: 1963: 1044:Hubel DH, Livingstone MS (1987). 681:"Harvard Brain Science Institute" 338:and other amine neurotransmitters 228:as an inhibitory neurotransmitter 614:. Oxford University Press, USA. 541:. Oxford University Press, USA. 316:The Department currently has 38 1935: 1911: 1887: 1871:"Ph.D. Program in Neuroscience" 1863: 1820: 1763: 1720: 1663: 1628: 1571: 1514: 1457: 1400: 1343: 1308: 1251: 1202: 1145: 1088: 1037: 1002: 945: 888: 831: 788: 745: 702: 673: 653: 628: 603: 579: 555: 530: 161:Massachusetts General Hospital 1: 523: 435:NIH Director's Pioneer Awards 347:, mice, and nonhuman primates 304:Pain receptor specific local 1741:10.1126/science.286.5440.768 1688:10.1016/j.neuron.2009.04.018 1596:10.1016/j.neuron.2015.11.031 1482:10.1016/j.neuron.2012.03.032 1329:10.1016/0896-6273(91)90343-x 766:10.1126/science.125.3247.549 587:"Department of Neurobiology" 473:Gruber Prize in Neuroscience 295:in mammalian circadian clock 268:The molecular impact of the 66:http://neuro.hms.harvard.edu 7: 1264:The Journal of Cell Biology 612:Brain and Visual Perception 539:Brain and Visual Perception 412:(faculty member 1991–2001) 10: 2026: 913:10.1016/j.cell.2014.03.058 711:Journal of Neurophysiology 366:Neuropsychiatric disorders 278:development and regulation 153:Boston Children’s Hospital 103: 402:(faculty member 1992–96) 362:Autism Spectrum Disorders 298:New treatment target for 157:Dana-Farber Cancer Center 61: 51: 41: 33: 24: 1980:Harvard Brain Initiative 723:10.1152/jn.1963.26.6.978 483:(faculty member 1981–84) 468:(current faculty member) 445:(current faculty member) 430:(faculty member 1992–96) 353:Neurobiology of Behavior 208:ocular dominance columns 1113:10.1126/science.1119983 1050:Journal of Neuroscience 344:Drosophila melanogaster 212:orientation selectivity 2005:Harvard Medical School 1985:Harvard Medical School 1276:10.1083/jcb.107.3.1113 1228:10.1074/jbc.M005441200 639:. Sinauer Associates. 350:Ion channel physiology 197:retinal ganglion cells 91:Harvard Medical School 79:Harvard Medical School 610:Hubel, David (2005). 591:neuro.hms.harvard.edu 537:Hubel, David (2005). 235:Central sensitization 83:Longwood Medical Area 661:"A Personal History" 635:McMahan, UJ (1990). 518:Margaret Livingstone 512:Bernardo L. Sabatini 488:Michael E. Greenberg 334:Characterization of 149:Michael E. Greenberg 1875:www.hms.harvard.edu 1841:10.1038/nature06191 1539:10.1038/nature13324 1425:10.1038/nature09033 1368:10.1038/nature14179 1221:(37): 28666–28674. 1170:10.1038/nature06864 970:10.1038/nature14319 856:10.1038/nature09033 276:Blood brain barrier 21: 1947:www.nobelprize.org 1923:www.nobelprize.org 1899:www.nobelprize.org 428:Roderick MacKinnon 400:Roderick MacKinnon 169:Harvard University 95:Stephen W. Kuffler 81:is located in the 73:The Department of 19: 1835:(7162): 607–610. 1782:(11): 1518–1523. 1735:(5440): 768–771. 1533:(7501): 507–511. 1419:(7295): 182–187. 1164:(7190): 956–960. 1107:(5761): 670–674. 850:(7295): 182–187. 803:(4826): 382–383. 760:(3247): 549–550. 685:brain.harvard.edu 443:Rosalind A. Segal 110:Torsten N. Wiesel 71: 70: 2017: 1957: 1956: 1954: 1953: 1939: 1933: 1932: 1930: 1929: 1915: 1909: 1908: 1906: 1905: 1891: 1885: 1884: 1882: 1881: 1867: 1861: 1860: 1824: 1818: 1817: 1807: 1767: 1761: 1760: 1724: 1718: 1717: 1707: 1667: 1661: 1660: 1649:10.1038/384170a0 1632: 1626: 1625: 1615: 1590:(6): 1121–1135. 1575: 1569: 1568: 1558: 1518: 1512: 1511: 1501: 1461: 1455: 1454: 1444: 1404: 1398: 1397: 1387: 1347: 1341: 1340: 1312: 1306: 1305: 1295: 1270:(3): 1113–1121. 1255: 1249: 1248: 1230: 1206: 1200: 1199: 1189: 1149: 1143: 1142: 1132: 1092: 1086: 1085: 1075: 1065: 1056:(11): 3378–415. 1041: 1035: 1034: 1023:10.1038/306686a0 1006: 1000: 999: 989: 949: 943: 942: 932: 907:(5): 1216–1229. 892: 886: 885: 875: 835: 829: 828: 809:10.1038/194382b0 792: 786: 785: 749: 743: 742: 706: 700: 699: 697: 696: 687:. 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Index


Chairman
http://neuro.hms.harvard.edu
Neurobiology
Harvard Medical School
Longwood Medical Area
Boston, MA
Harvard Medical School
Stephen W. Kuffler
Torsten N. Wiesel
David Hubel
Ed Kravitz
Otto Krayer
Gerald Fishbach
Carla Shatz
Michael E. Greenberg
Boston Children’s Hospital
Dana-Farber Cancer Center
Massachusetts General Hospital
Massachusetts Eye and Ear Infirmary
Harvard University
Cambridge, MA
50th Anniversary
retinal ganglion cells
critical periods
ocular dominance columns
orientation selectivity
Nobel Prize in Physiology or Medicine
GABA
Central sensitization

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