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Connective tissue disease

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Bardhan, Ajoy; Bruckner-Tuderman, Leena; Chapple, Iain L. C.; Fine, Jo-David; Harper, Natasha; Has, Cristina; Magin, Thomas M.; Marinkovich, M. Peter; Marshall, John F.; McGrath, John A.; Mellerio, Jemima E.; Polson, Rex; Heagerty, Adrian H. (2020-09-24). "Epidermolysis bullosa".
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Phornphutkul, Chanika; Introne, Wendy J.; Perry, Monique B.; Bernardini, Isa; Murphey, Mark D.; Fitzpatrick, Diana L.; Anderson, Paul D.; Huizing, Marjan; Anikster, Yair; Gerber, Lynn H.; Gahl, William A. (2002-12-26). "Natural History of Alkaptonuria".
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580:- unclassifiable systemic autoimmune disorders that do not meet any of the current classification requirements for connective tissue diseases yet have clinical and serological signs similar to connective tissue diseases. 1621:
Brito-Zerón, Pilar; Baldini, Chiara; Bootsma, Hendrika; Bowman, Simon J.; Jonsson, Roland; Mariette, Xavier; Sivils, Kathy; Theander, Elke; Tzioufas, Athanasios; Ramos-Casals, Manuel (2016-07-07). "Sjögren syndrome".
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affecting the primary structure of connective tissue, and (2) a variety of acquired diseases where the connective tissues are the site of multiple, more or less distinct immunological and inflammatory reactions.
3935: 2199: 216:. Many result in anomalies of the skeleton and joints, which can substantially impair normal growth and development. In contrast to acquired connective tissue diseases, these conditions are uncommon. 1849:
Tani, Chiara; Carli, Linda; Vagnani, Sabrina; Talarico, Rosaria; Baldini, Chiara; Mosca, Marta; Bombardieri, Stefano (2014). "The diagnosis and classification of mixed connective tissue disease".
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Mosca, Marta; Tani, Chiara; Vagnani, Sabrina; Carli, Linda; Bombardieri, Stefano (2014). "The diagnosis and classification of undifferentiated connective tissue diseases".
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Stattin, E.-L.; Tegner, Y.; Domellöf, M.; Dahl, N. (2008). "Familial osteochondritis dissecans associated with early osteoarthritis and disproportionate short stature".
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are all made of collagen. Skin and ligaments contain elastin. The proteins and the body's surrounding tissues may suffer damage when these connective tissues become
4158: 548:- uncommon multisystem autoimmune disease with an unclear etiology that is marked by progressive cartilaginous tissue loss and recurring episodes of inflammation. 4026: 3430: 514:- uncommon condition caused by protein mutations or changes in the body that result in twisted clusters of malformed proteins accumulating on organs and tissues. 1030:
Kaplan, Frederick S.; Le Merrer, Martine; Glaser, David L.; Pignolo, Robert J.; Goldsby, Robert E.; Kitterman, Joseph A.; Groppe, Jay; Shore, Eileen M. (2008).
255:- diverse collection of disorders distinguished by the fragility of soft connective tissues and widespread symptoms affecting the skin, ligaments, joints, 2681: 1426:
American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines (2002). "Guidelines for the management of rheumatoid arthritis: 2002 Update".
3459: 3425: 2530: 192:; and (2) a number of acquired conditions where the connective tissues are the site of multiple, more or less distinct immune and inflammatory reactions. 2520: 390:- autosomal dominant condition linked to a wide range of systemic manifestations, such as skeletal, cutaneous, vascular, and craniofacial abnormalities. 2947: 2729: 1176:
Warady, Bradley A.; Agarwal, Rajiv; Bangalore, Sripal; Chapman, Arlene; Levin, Adeera; Stenvinkel, Peter; Toto, Robert D.; Chertow, Glenn M. (2020).
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Hereditary connective tissue disorders are a diverse set of broad, single-gene disorders that impact one or more of the main components of
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Atwell, Karina; Michael, William; Dubey, Jared; James, Sarah; Martonffy, Andrea; Anderson, Scott; Rudin, Nathan; Schrager, Sarina (2021).
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Spagnolo, Paolo; Cordier, Jean-François; Cottin, Vincent (2016-02-25). "Connective tissue diseases, multimorbidity and the ageing lung".
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Fett, Nicole (2013). "Scleroderma: Nomenclature, etiology, pathogenesis, prognosis, and treatments: Facts and controversies".
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Mammen, Andrew L. (2010). "Dermatomyositis and polymyositis: Clinical presentation, autoantibodies, and pathogenesis".
554:- systemic autoimmune disease that shares characteristics with two or more other systemic autoimmune diseases, such as 409:
Acquired connective tissue diseases share certain clinical features, such as joint inflammation, inflammation of 
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Kumar, Tarun; Sharma, Gurumayum Suraj; Singh, Laishram Rajendrakumar (2016). "Homocystinuria: Therapeutic approach".
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risks. Others may be due to environmental factors, or a combination of genetic and environmental influences.
3591: 3283: 2979: 2668: 2488: 2236: 567: 439: 417:, as well as a high frequency of involvement of various internal organs that are particularly rich in 349: 682:
Pepe, Guglielmina; Giusti, Betti; Sticchi, Elena; Abbate, Rosanna; Gensini, Gian; Nistri, Stefano (2016).
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Joly, Bérangère S.; Coppo, Paul; Veyradier, Agnès (2017-05-25). "Thrombotic thrombocytopenic purpura".
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COJOCARU, Manole; COJOCARU, Inimioara Mihaela; SILOSI, Isabela; VRABIE, Camelia Doina (2024-03-14).
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can be (but are not necessarily) associated with collagen and blood vessel abnormalities that are
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Diseases in which inflammation or weakness of collagen tends to occur are also referred to as
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and causes mucosal surfaces, especially those in the mouth and eyes, to become extremely dry.
377: 338:- autosomal dominant disorder distinguished by skeletal, ocular, and orofacial abnormalities. 300: 184:
Connective tissue diseases can be classified into two groups: (1) a group of relatively rare
2455: 520:- common articular cartilage degenerative disease linked to hypertrophic bone abnormalities. 106:. The body's structures are held together by connective tissues, consisting of two distinct 4093: 3995: 3513: 3130: 3058: 2882: 2744: 2696: 2525: 2510: 2389: 2339: 2322: 2273: 1336:
Gouda, Pishoy; Kay, Robert; Habib, Marina; Aziz, Amir; Aziza, Eitan; Welsh, Robert (2022).
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De Paepe, A; Malfait, F (2012). "The Ehlers–Danlos syndrome, a disorder with many faces".
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The two main categories of connective tissue diseases are (1) a set of relatively rare
4188: 4148: 4070: 3945: 3889: 3823: 3488: 2724: 2610: 2557: 2427: 2409: 2399: 2015: 2007: 1968: 1950: 1909: 1901: 1870: 1862: 1831: 1823: 1788: 1780: 1690: 1682: 1647: 1639: 1578: 1570: 1566: 1535: 1527: 1492: 1451: 1443: 1408: 1400: 1359: 1318: 1310: 1274: 1256: 1215: 1197: 1151: 1147: 1112: 1104: 1069: 1051: 987: 969: 930: 922: 886: 878: 840: 809: 801: 797: 766: 758: 723: 705: 605: 418: 353: 335: 293:- rare multisystem disease marked by gradual calcification and fragmentation of  205: 201: 189: 103: 66: 59: 4075: 3710: 3521: 3493: 3102: 3083: 2898: 2779: 2749: 2562: 2394: 2036: 1999: 1958: 1945: 1940: 1893: 1854: 1815: 1772: 1674: 1631: 1562: 1519: 1482: 1435: 1390: 1349: 1302: 1264: 1246: 1205: 1189: 1143: 1096: 1059: 1043: 977: 961: 914: 870: 832: 793: 750: 713: 695: 600: 539: 531: 325: 185: 158: 150: 1338:"Clinical features and complications of Loeys-Dietz syndrome: A systematic review" 4098: 3616: 3165: 3025: 2997: 2110: 1776: 1395: 1378: 1354: 1337: 563: 527: 501: 471: 455: 410: 367: 341: 220: 3936:
Keratosis linearis with ichthyosis congenita and sclerosing keratoderma syndrome
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connected to diffuse microvascular platelet rich-thrombi, and microangiopathic
517: 495: 371: 363: 345: 234: 1678: 1379:"Diagnosis and Management of Hypermobility Spectrum Disorders in Primary Care" 1306: 754: 396:- a variety of connective tissue diseases that are marked by ongoing pain and 313:- rare and debilitating hereditary disorder characterized by progressive  4267: 4060: 3980: 3564: 2917: 2903: 2844: 2374: 2011: 1954: 1905: 1866: 1827: 1784: 1686: 1643: 1574: 1531: 1447: 1404: 1314: 1260: 1201: 1108: 1055: 973: 926: 882: 805: 762: 709: 294: 270: 223:- inherited as an autosomal dominant characteristic, due to mutations in the 965: 50: 4065: 4055: 3991: 3972: 3222: 3034: 2771: 2587: 2019: 1972: 1913: 1874: 1835: 1792: 1694: 1651: 1582: 1539: 1496: 1455: 1412: 1363: 1322: 1278: 1251: 1219: 1116: 1073: 991: 934: 890: 813: 770: 727: 559: 485: 475: 467: 459: 276: 266: 256: 246: 143: 139: 71: 1155: 4228: 3837: 3716: 3692: 3050: 2706: 2577: 2442: 2222: 2156: 2151: 2140: 1635: 918: 511: 449: 228: 3238: 2207: 2097: 2027:
Baildam, Eileen (2014). "Rare connective tissue diseases in childhood".
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Template:Congenital malformations and deformations of skin appendages
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Marini, Joan C.; Cabral, Wayne A. (2018). "Osteogenesis Imperfecta".
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that are clinically characterized by extramuscular symptoms, muscle
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is distinguished by structural abnormalities and malfunction in the
303:- a class of hereditary illnesses distinguished by the excretion of 3966: 3851: 3663: 3015: 1291: 535: 463: 446:
inflammatory disorder that can affect every organ in the body.
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that are marked by blisters and mucocutaneous fragility.
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Focal palmoplantar keratoderma with oral mucosal hyperkeratosis
2913: 2626: 2582: 2422: 2334: 1620: 504:- multisystem inflammatory illness that develops after group A 119: 1665:
Rullan, Eugenia; Sigal, Leonard H. (2001). "Rheumatic fever".
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with an unclear cause that manifests as symmetric, erosive
224: 135: 127: 1710:"Amyloidosis: What It Is, Symptoms, Types & Treatment" 1235:"Congenital contractural arachnodactyly (Beals syndrome)" 1086: 404: 4159:
Congenital hypertrophy of the lateral fold of the hallux
2962: 1848: 1799: 494:- a systemic autoimmune illness that mostly affects the 452:- diverse collection of autoimmune fibrosing conditions. 195: 4027:
Template:DNA replication and repair-deficiency disorder
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Connective tissue disorder, collagen vascular diseases
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Cutaneous keratosis, ulcer, atrophy, and necrobiosis
2087: 2065:"Connective Tissue Disease: Types, Symptoms, Causes" 1998:(5). European Respiratory Society (ERS): 1535–1558. 1708:
Cleveland Clinic medical professional (2022-07-05).
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Cleveland Clinic medical professional (2024-05-01).
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The Journal of the American Board of Family Medicine
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Benedek, Thomas G.; Rodnan, Gerald P. (1998-07-24).
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Some connective tissue diseases have strong or weak
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Palisaded neutrophilic and granulomatous dermatitis
586:- inflammatory musculoskeletal condition linked to 2682:Lupus erythematosus–lichen planus overlap syndrome 1808:Best Practice & Research Clinical Rheumatology 1762: 1301:(1). Springer Science and Business Media LLC: 78. 1036:Best Practice & Research Clinical Rheumatology 869:(1). Springer Science and Business Media LLC: 16. 3643:Diffuse nonepidermolytic palmoplantar keratoderma 1481:(4). Amaltea Medical, Editura Magister: 330–336. 1335: 1130:Bennett, James; McMurray, Scott (November 1990). 4265: 3367:Nonbullous congenital ichthyosiform erythroderma 1927:Ocampo D, Vanessa; Gladman, Dafna (2019-09-20). 1842: 1471:"Manifestations of Systemic Lupus Erythematosus" 740: 3832:Palmoplantar keratoderma and spastic paraplegia 1926: 1806:GERGELY, P (2004). "Relapsing polychondritis". 1658: 1232: 1178:"Alport Syndrome Classification and Management" 1129: 783: 380:- hereditary, diverse grouping of rare genetic 3638:Diffuse epidermolytic palmoplantar keratoderma 2730:Morphea–lichen sclerosus et atrophicus overlap 1726: 436:and, occasionally, extraarticular involvement. 4169:Congenital malformations of the dermatoglyphs 3199: 2948: 2193: 1598:"Vasculitis: Symptoms, Types & Treatment" 897: 853: 829:Genetics of Bone Biology and Skeletal Disease 734: 631: 269:, weakened bones, increased brittleness, and 826: 777: 627: 625: 623: 621: 526:- uncommon and potentially fatal thrombotic 2058:. National Library of Medicine. 2017-09-15. 1701: 1664: 1503: 650: 249:and its metabolites in the urine and blood. 4194:Melanotic neuroectodermal tumor of infancy 3931:Keratosis follicularis spinulosa decalvans 3362:Ichthyosis–sclerosing cholangitis syndrome 3206: 3192: 2955: 2941: 2200: 2186: 1589: 1555:Annals of the New York Academy of Sciences 1233:Tunçbilek, ErgĂĽl; Alanay, Yasemin (2006). 578:Undifferentiated connective tissue disease 366:, multiple flexion contractures, abnormal 76: 49: 4154:Congenital cartilaginous rest of the neck 3749:Focal palmoplantar and gingival keratosis 2294:Seborrheic keratosis with squamous atypia 1962: 1944: 1920: 1735:"Osteoarthritis: Diagnosis and Treatment" 1486: 1394: 1353: 1268: 1250: 1209: 1063: 981: 717: 699: 618: 362:- autosomal dominant disorder defined by 265:- hereditary condition marked by reduced 4219:Rapidly involuting congenital hemangioma 3809:Keratosis punctata of the palmar creases 3804:Keratosis punctata palmaris et plantaris 3675:Clouston's hidrotic ectodermal dysplasia 2535:Interstitial granulomatous drug reaction 2506:Annular elastolytic giant-cell granuloma 2328:Confluent and reticulated papillomatosis 2311:Keratosis punctata of the palmar creases 1123: 356:in other organs such as the eye and ear. 283:caused by mutations in the HGO gene and 2380:Multiple minute digitate hyperkeratosis 2365:Hyperkeratosis of the nipple and areola 1805: 1732: 1614: 1032:"Fibrodysplasia ossificans progressiva" 684:"Marfan syndrome: current perspectives" 245:deficit that causes a build-up of 14: 4266: 3171:Congenital contractural arachnodactyly 2237:Acrokeratosis paraneoplastica of Bazex 1552: 405:Autoimmune connective tissue disorders 360:Congenital contractural arachnodactyly 317:and congenital skeletal malformations. 3280:Congenital ichthyosiform erythroderma 3187: 2936: 2827:Atrophia maculosa varioliformis cutis 2531:Interstitial granulomatous dermatitis 2181: 1546: 1462: 947: 675: 311:Fibrodysplasia ossificans progressiva 196:Heritable connective tissue disorders 4274:Systemic connective tissue disorders 3941:Keratosis pilaris atrophicans faciei 3526:Dermatopathia pigmentosa reticularis 2355:Hyperkeratosis lenticularis perstans 1881: 1509: 1169: 688:The Application of Clinical Genetics 634:"Description, Types, & Symptoms" 2807:Acrodermatitis chronica atrophicans 1756: 1370: 1342:International Journal of Cardiology 820: 524:Thrombotic thrombocytopenic purpura 188:affecting the primary structure of 24: 4234:Superficial lymphatic malformation 4179:Congenital smooth muscle hamartoma 3648:Palmoplantar keratoderma of Sybert 3217:malformations and deformations of 2909:Poikiloderma vasculare atrophicans 2802:Atrophoderma of Pasini and Pierini 2740:Atrophoderma of Pasini and Pierini 1983: 1524:10.1016/j.clindermatol.2013.01.010 1419: 837:10.1016/b978-0-12-804182-6.00023-x 474:, and oftentimes the detection of 25: 4285: 3706:Scleroatrophic syndrome of Huriez 3536:Hypohidrotic ectodermal dysplasia 2850:Reactive perforating collagenosis 2484:Granuloma annulare in HIV disease 2048: 1239:Orphanet Journal of Rare Diseases 1136:Journal of Pediatric Orthopaedics 179: 3819:Porokeratosis plantaris discreta 3776:Striate palmoplantar keratoderma 2299:Reticulated seborrheic keratosis 2063:Dunkin, Mary Anne (2023-10-10). 1567:10.1111/j.1749-6632.2009.05119.x 1148:10.1097/01241398-199011000-00010 954:Archives of Disease in Childhood 798:10.1111/j.1399-0004.2012.01858.x 4244:Verrucous vascular malformation 4174:Congenital preauricular fistula 4144:Accessory nail of the fifth toe 4021:Template:Pigmentation disorders 3814:Schöpf–Schulz–Passarge syndrome 3794:Acrokeratoelastoidosis of Costa 3499:Laryngoonychocutaneous syndrome 3372:Ichthyosis linearis circumflexa 3357:Ichthyosis prematurity syndrome 3088:Mixed connective tissue disease 2865:Acquired perforating dermatosis 2855:Elastosis perforans serpiginosa 2795:Jadassohn–Pellizzari anetoderma 907:New England Journal of Medicine 552:Mixed connective tissue disease 394:Hypermobility spectrum disorder 3858:Erythrokeratodermia variabilis 3769:Pachyonychia congenita type II 3064:Progressive systemic sclerosis 2289:Irritated seborrheic keratosis 1946:10.12688/f1000research.19144.1 1624:Nature Reviews Disease Primers 1295:Nature Reviews Disease Primers 863:Nature Reviews Disease Primers 831:. Elsevier. pp. 397–420. 13: 1: 4184:Cystic lymphatic malformation 4137:Cavernous venous malformation 3764:Pachyonychia congenita type I 3687:Corneodermatoosseous syndrome 3347:Ichthyosis bullosa of Siemens 3151:Eosinophilia–myalgia syndrome 2822:Linear atrophoderma of Moulin 2494:Patch-type granuloma annulare 2370:Inverted follicular keratosis 2056:"Connective Tissue Disorders" 1892:. 48–49. Elsevier BV: 50–52. 1853:. 48–49. Elsevier BV: 46–49. 1733:Sinusas, Keith (2012-01-01). 1006:"Mucopolysaccharidoses (MPS)" 658:"Connective Tissue Disorders" 611: 285:homogentisate 1,2-dioxygenase 3592:Popliteal pterygium syndrome 3284:Epidermolytic hyperkeratosis 2980:Systemic lupus erythematosus 2790:Schweninger–Buzzi anetoderma 2489:Localized granuloma annulare 2077:"Connective tissue diseases" 2029:Paediatrics and Child Health 1992:European Respiratory Journal 1939:. F1000 Research Ltd: 1665. 1777:10.1182/blood-2016-10-709857 1667:Current Rheumatology Reports 1396:10.3122/jabfm.2021.04.200374 1355:10.1016/j.ijcard.2022.05.065 1089:Osteoarthritis and Cartilage 568:systemic lupus erythematosus 440:Systemic lupus erythematosus 350:glomerular basement membrane 332:from the surrounding tissue. 204:, such as ground substance ( 7: 4224:Rosenthal–Kloepfer syndrome 4209:Omphalomesenteric duct cyst 3926:Keratolytic winter erythema 3586:Gerodermia osteodysplastica 2965:connective tissue disorders 2516:Necrobiotic xanthogranuloma 2415:Waxy keratosis of childhood 2284:Common seborrheic keratosis 2279:Clonal seborrheic keratosis 2261:Keratoderma blennorrhagicum 2004:10.1183/13993003.00829-2015 1814:(5). Elsevier BV: 723–738. 1518:(4). Elsevier BV: 432–437. 1188:(5). Elsevier BV: 639–649. 1095:(8). Elsevier BV: 890–896. 1042:(1). Elsevier BV: 191–205. 594: 241:metabolism brought on by a 10: 4290: 3799:Focal acral hyperkeratosis 3546:Ellis–van Creveld syndrome 2232:Paraneoplastic keratoderma 2041:10.1016/j.paed.2013.12.005 1898:10.1016/j.jaut.2014.01.019 1859:10.1016/j.jaut.2014.01.008 1820:10.1016/j.berh.2004.05.012 1428:Arthritis & Rheumatism 1194:10.1016/j.xkme.2020.05.014 1101:10.1016/j.joca.2007.11.009 1048:10.1016/j.berh.2007.11.007 950:"Pseudoxanthoma elasticum" 875:10.1038/s41572-024-00498-x 484:- disease that results in 374:, and muscular hypoplasia. 281:inborn error of metabolism 163:Collagen vascular diseases 96:collagen vascular diseases 92:connective tissue disorder 4114: 4084: 4048: 4039: 3958: 3877: 3723:Papillon–Lefèvre syndrome 3624: 3610: 3563: 3512: 3389: 3339: 3321: 3294:Harlequin-type ichthyosis 3270: 3252: 3229: 3123: 3100: 3079: 3049: 3006: 2993:Libman–Sacks endocarditis 2978: 2971: 2891: 2873: 2835: 2765: 2705: 2640: 2625: 2596: 2543: 2454: 2441: 2304:Dermatosis papulosa nigra 2227:Keratoderma climactericum 2213: 2131: 2091: 1739:American Family Physician 1679:10.1007/s11926-996-0016-4 1307:10.1038/s41572-020-0210-0 755:10.1016/j.cca.2016.04.002 506:streptococcal pharyngitis 322:osteochondritis dissecans 88:Connective tissue disease 65: 57: 48: 40: 36:Connective tissue disease 35: 18:Collagen vascular disease 3597:Pseudoxanthoma elasticum 3313:Sjögren–Larsson syndrome 3030:Juvenile dermatomyositis 2860:Perforating folliculitis 2812:Semicircular lipoatrophy 2249:Drug-induced keratoderma 546:Relapsing polychondritis 530:characterized by severe 315:heterotopic ossification 291:Pseudoxanthoma elasticum 243:cystathionine β-synthase 4122:Aplasia cutis congenita 3541:Focal dermal hypoplasia 3504:Skin fragility syndrome 3352:Ichthyosis follicularis 3039:Inclusion body myositis 2817:Follicular atrophoderma 2605:eosinophilic dermatosis 1890:Journal of Autoimmunity 1851:Journal of Autoimmunity 966:10.1136/adc.2004.062075 948:Laube, S (2005-07-01). 638:Encyclopedia Britannica 263:Osteogenesis imperfecta 4239:Thyroglossal duct cyst 4204:Nasolacrimal duct cyst 4127:Amniotic band syndrome 3921:Dyskeratosis congenita 3909:Dyskeratosis congenita 3759:Pachyonychia congenita 3670:Bart–Pumphrey syndrome 3602:Van der Woude syndrome 3577:Ehlers–Danlos syndrome 3156:Ehlers–Danlos syndrome 3146:Eosinophilic fasciitis 3141:Polymyalgia rheumatica 2545:Foreign body granuloma 2456:Necrobiotic/palisading 2350:Chronic scar keratosis 1512:Clinics in Dermatology 1252:10.1186/1750-1172-1-20 1010:Johns Hopkins Medicine 749:. Elsevier BV: 55–62. 259:, and internal organs. 253:Ehlers–Danlos syndrome 4104:Nevus flammeus nuchae 4015:Template:Phakomatoses 3987:Hereditary lymphedema 3551:Rapp–Hodgkin syndrome 3240:Congenital ichthyosis 3008:Inflammatory myopathy 2720:Localized scleroderma 2501:Necrobiosis lipoidica 2433:Cutis verticis gyrata 2360:Hydrocarbon keratosis 2244:Aquagenic keratoderma 1929:"Psoriatic arthritis" 411:serous membranes 378:Epidermolysis bullosa 301:Mucopolysaccharidosis 4094:Capillary hemangioma 3996:Urticaria pigmentosa 3754:Howel–Evans syndrome 3514:Ectodermal dysplasia 3455:Generalized atrophic 3131:IgG4-related disease 3059:Systemic scleroderma 2883:Pyoderma gangrenosum 2745:Pansclerotic morphea 2526:Rheumatoid nodulosis 2511:Granuloma multiforme 2390:Reactional keratosis 2340:Ichthyosis acquisita 2323:Acanthosis nigricans 2274:Seborrheic keratosis 2215:Epidermal thickening 1636:10.1038/nrdp.2016.47 919:10.1056/NEJMoa021736 743:Clinica Chimica Acta 556:rheumatoid arthritis 426:Rheumatoid arthritis 388:Loeys–Dietz syndrome 324:- separation of the 27:Category of diseases 3781:Tyrosinemia type II 3331:X-linked ichthyosis 3289:Lamellar ichthyosis 3262:Ichthyosis vulgaris 3245:erythrokeratodermia 3021:Dermatopolymyositis 2735:Generalized morphea 2573:Zirconium granuloma 2553:Beryllium granuloma 2421:other hypertrophy: 2375:Lichenoid keratosis 2345:Arsenical keratosis 1132:"Stickler Syndrome" 701:10.2147/TACG.S96233 584:Psoriatic arthritis 442:- chronic, complex 398:joint hypermobility 174:genetic inheritance 58:Different types of 4164:Congenital lip pit 3728:Haim–Munk syndrome 3680:Vohwinkel syndrome 3555:Hay–Wells syndrome 3531:Hay–Wells syndrome 3377:Ichthyosis hystrix 3303:Netherton syndrome 2755:Linear scleroderma 2568:Silicone granuloma 2464:Granuloma annulare 2132:External resources 572:systemic sclerosis 430:autoimmune disease 354:basement membranes 352:, as well as 305:mucopolysaccharide 227:gene that encodes 206:glycosaminoglycans 202:connective tissues 4261: 4260: 4257: 4256: 4189:Median raphe cyst 4149:Bronchogenic cyst 4071:PHACE association 4035: 4034: 3954: 3953: 3946:Keratosis pilaris 3890:Keratosis pilaris 3844:Carvajal syndrome 3824:Spiny keratoderma 3489:Costello syndrome 3385: 3384: 3181: 3180: 3096: 3095: 2930: 2929: 2926: 2925: 2725:Localized morphea 2697:Rowell's syndrome 2621: 2620: 2611:Granuloma faciale 2558:Mercury granuloma 2428:Hypertrophic scar 2410:Warty dyskeratoma 2400:Thermal keratosis 2175: 2174: 1771:(21): 2836–2846. 1440:10.1002/art.10148 913:(26): 2111–2121. 846:978-0-12-804182-6 786:Clinical Genetics 606:Connective tissue 419:connective tissue 336:Stickler syndrome 190:connective tissue 186:genetic disorders 159:collagen diseases 151:genetic disorders 104:connective tissue 85: 84: 60:connective tissue 30:Medical condition 16:(Redirected from 4281: 4076:Sinus pericranii 4046: 4045: 3902:Darier's disease 3711:Olmsted syndrome 3622: 3621: 3522:Naegeli syndrome 3494:Kindler syndrome 3250: 3249: 3236: 3235: 3208: 3201: 3194: 3185: 3184: 3136:Behçet's disease 3115:Sjögren syndrome 3103:hypersensitivity 3084:Overlap syndrome 2988:Drug-induced SLE 2976: 2975: 2957: 2950: 2943: 2934: 2933: 2899:Calcinosis cutis 2780:Lichen sclerosus 2750:Morphea profunda 2638: 2637: 2563:Silica granuloma 2452: 2451: 2395:Stucco keratosis 2202: 2195: 2188: 2179: 2178: 2089: 2088: 2084: 2072: 2059: 2044: 2023: 1977: 1976: 1966: 1948: 1924: 1918: 1917: 1885: 1879: 1878: 1846: 1840: 1839: 1803: 1797: 1796: 1760: 1754: 1753: 1751: 1750: 1730: 1724: 1723: 1721: 1720: 1714:Cleveland Clinic 1705: 1699: 1698: 1662: 1656: 1655: 1618: 1612: 1611: 1609: 1608: 1602:Cleveland Clinic 1593: 1587: 1586: 1550: 1544: 1543: 1507: 1501: 1500: 1490: 1466: 1460: 1459: 1423: 1417: 1416: 1398: 1374: 1368: 1367: 1357: 1333: 1327: 1326: 1289: 1283: 1282: 1272: 1254: 1230: 1224: 1223: 1213: 1173: 1167: 1166: 1164: 1162: 1127: 1121: 1120: 1084: 1078: 1077: 1067: 1027: 1021: 1020: 1018: 1017: 1002: 996: 995: 985: 945: 939: 938: 901: 895: 894: 857: 851: 850: 824: 818: 817: 781: 775: 774: 738: 732: 731: 721: 703: 679: 673: 672: 670: 669: 654: 648: 647: 645: 644: 629: 601:Overlap syndrome 540:hemolytic anemia 532:thrombocytopenia 492:Sjögren syndrome 472:muscle weakening 326:subchondral bone 102:that affect the 98:, refers to any 90:, also known as 81: 80: 53: 33: 32: 21: 4289: 4288: 4284: 4283: 4282: 4280: 4279: 4278: 4264: 4263: 4262: 4253: 4115:Other/ungrouped 4110: 4099:Port-wine stain 4080: 4041: 4031: 3950: 3873: 3615: 3606: 3559: 3508: 3393: 3381: 3335: 3317: 3266: 3243: 3225: 3212: 3182: 3177: 3166:Marfan syndrome 3119: 3092: 3075: 3045: 3026:Dermatomyositis 3002: 2998:Lupus nephritis 2967: 2961: 2931: 2922: 2887: 2869: 2831: 2770: 2761: 2710: 2701: 2643: 2642:Cutaneous lupus 2630: 2617: 2597:Other/ungrouped 2592: 2539: 2437: 2405:Viral keratosis 2209: 2206: 2176: 2171: 2170: 2127: 2126: 2100: 2075: 2062: 2054: 2051: 2026: 1989: 1986: 1984:Further reading 1981: 1980: 1925: 1921: 1886: 1882: 1847: 1843: 1804: 1800: 1761: 1757: 1748: 1746: 1731: 1727: 1718: 1716: 1706: 1702: 1663: 1659: 1619: 1615: 1606: 1604: 1594: 1590: 1551: 1547: 1508: 1504: 1467: 1463: 1424: 1420: 1375: 1371: 1334: 1330: 1290: 1286: 1231: 1227: 1182:Kidney Medicine 1174: 1170: 1160: 1158: 1128: 1124: 1085: 1081: 1028: 1024: 1015: 1013: 1004: 1003: 999: 946: 942: 902: 898: 858: 854: 847: 825: 821: 782: 778: 739: 735: 680: 676: 667: 665: 656: 655: 651: 642: 640: 630: 619: 614: 597: 564:dermatomyositis 528:microangiopathy 502:Rheumatic fever 496:exocrine glands 456:Dermatomyositis 407: 342:Alport syndrome 237:- condition of 221:Marfan syndrome 198: 182: 75: 31: 28: 23: 22: 15: 12: 11: 5: 4287: 4277: 4276: 4259: 4258: 4255: 4254: 4252: 4251: 4246: 4241: 4236: 4231: 4226: 4221: 4216: 4214:Poland anomaly 4211: 4206: 4201: 4199:Mongolian spot 4196: 4191: 4186: 4181: 4176: 4171: 4166: 4161: 4156: 4151: 4146: 4140: 4139: 4134: 4132:Branchial cyst 4129: 4124: 4118: 4116: 4112: 4111: 4109: 4108: 4107: 4106: 4096: 4090: 4088: 4082: 4081: 4079: 4078: 4073: 4068: 4063: 4058: 4052: 4050: 4043: 4037: 4036: 4033: 4032: 4006: 4005: 4000: 3999: 3998: 3989: 3977: 3976: 3975: 3962: 3960: 3956: 3955: 3952: 3951: 3949: 3948: 3943: 3938: 3933: 3928: 3923: 3917: 3916: 3914:Lelis syndrome 3911: 3906: 3905: 3904: 3892: 3887: 3885:Meleda disease 3881: 3879: 3875: 3874: 3872: 3871: 3870: 3869: 3860: 3848: 3847: 3846: 3834: 3827: 3826: 3821: 3816: 3811: 3806: 3801: 3796: 3786: 3785: 3784: 3783: 3778: 3773: 3772: 3771: 3766: 3756: 3751: 3746: 3737: 3735:Camisa disease 3732: 3731: 3730: 3725: 3713: 3708: 3703: 3702: 3701: 3699:Naxos syndrome 3689: 3684: 3683: 3682: 3677: 3672: 3656: 3655: 3653:Meleda disease 3650: 3645: 3640: 3630: 3628: 3619: 3612:Hyperkeratosis 3608: 3607: 3605: 3604: 3599: 3594: 3589: 3579: 3573: 3571: 3561: 3560: 3558: 3557: 3548: 3543: 3538: 3533: 3528: 3518: 3516: 3510: 3509: 3507: 3506: 3501: 3496: 3491: 3484: 3483: 3482: 3481: 3476: 3465: 3464: 3463: 3462: 3457: 3452: 3447: 3436: 3435: 3434: 3433: 3428: 3423: 3418: 3413: 3408: 3397: 3395: 3387: 3386: 3383: 3382: 3380: 3379: 3374: 3369: 3364: 3359: 3354: 3349: 3343: 3341: 3337: 3336: 3334: 3333: 3327: 3325: 3319: 3318: 3316: 3315: 3310: 3308:CHIME syndrome 3305: 3299: 3298: 3297: 3296: 3286: 3276: 3274: 3268: 3267: 3265: 3264: 3258: 3256: 3247: 3233: 3231:Genodermatosis 3227: 3226: 3211: 3210: 3203: 3196: 3188: 3179: 3178: 3176: 3175: 3174: 3173: 3168: 3158: 3153: 3148: 3143: 3138: 3133: 3127: 3125: 3121: 3120: 3118: 3117: 3111: 3109: 3098: 3097: 3094: 3093: 3091: 3090: 3080: 3077: 3076: 3074: 3073: 3072: 3071: 3069:CREST syndrome 3066: 3055: 3053: 3047: 3046: 3044: 3043: 3042: 3041: 3032: 3018: 3012: 3010: 3004: 3003: 3001: 3000: 2995: 2990: 2984: 2982: 2973: 2969: 2968: 2960: 2959: 2952: 2945: 2937: 2928: 2927: 2924: 2923: 2921: 2920: 2911: 2906: 2901: 2895: 2893: 2889: 2888: 2886: 2885: 2879: 2877: 2871: 2870: 2868: 2867: 2862: 2857: 2852: 2847: 2841: 2839: 2833: 2832: 2830: 2829: 2824: 2819: 2814: 2809: 2804: 2799: 2798: 2797: 2792: 2782: 2776: 2774: 2763: 2762: 2760: 2759: 2758: 2757: 2752: 2747: 2742: 2737: 2732: 2727: 2716: 2714: 2703: 2702: 2700: 2699: 2694: 2689: 2684: 2679: 2672: 2671: 2661: 2660: 2655: 2648: 2646: 2635: 2623: 2622: 2619: 2618: 2616: 2615: 2614: 2613: 2600: 2598: 2594: 2593: 2591: 2590: 2585: 2580: 2575: 2570: 2565: 2560: 2555: 2549: 2547: 2541: 2540: 2538: 2537: 2528: 2523: 2518: 2513: 2508: 2503: 2498: 2497: 2496: 2491: 2486: 2481: 2476: 2471: 2460: 2458: 2449: 2439: 2438: 2436: 2435: 2430: 2425: 2418: 2417: 2412: 2407: 2402: 2397: 2392: 2387: 2385:PUVA keratosis 2382: 2377: 2372: 2367: 2362: 2357: 2352: 2347: 2342: 2337: 2332: 2331: 2330: 2319:hyperkeratosis 2314: 2313: 2308: 2307: 2306: 2301: 2296: 2291: 2286: 2281: 2266: 2265: 2264: 2263: 2251: 2246: 2241: 2240: 2239: 2229: 2219: 2217: 2211: 2210: 2205: 2204: 2197: 2190: 2182: 2173: 2172: 2169: 2168: 2159: 2148: 2136: 2135: 2133: 2129: 2128: 2125: 2124: 2113: 2101: 2096: 2095: 2093: 2092:Classification 2086: 2085: 2073: 2060: 2050: 2049:External links 2047: 2046: 2045: 2024: 1985: 1982: 1979: 1978: 1919: 1880: 1841: 1798: 1755: 1725: 1700: 1673:(5): 445–452. 1657: 1613: 1588: 1561:(1): 134–153. 1545: 1502: 1461: 1434:(2): 328–346. 1418: 1389:(4): 838–848. 1369: 1328: 1284: 1225: 1168: 1142:(6): 760–763. 1122: 1079: 1022: 997: 960:(7): 754–756. 940: 896: 852: 845: 819: 776: 733: 674: 649: 616: 615: 613: 610: 609: 608: 603: 596: 593: 592: 591: 581: 575: 549: 543: 521: 518:Osteoarthritis 515: 509: 499: 489: 479: 476:autoantibodies 453: 447: 437: 406: 403: 402: 401: 391: 385: 375: 372:kyphoscoliosis 364:arachnodactyly 357: 346:kidney disease 339: 333: 318: 308: 298: 295:elastic fibres 288: 274: 260: 250: 235:Homocystinuria 232: 197: 194: 181: 180:Classification 178: 83: 82: 69: 63: 62: 55: 54: 46: 45: 42: 38: 37: 29: 26: 9: 6: 4: 3: 2: 4286: 4275: 4272: 4271: 4269: 4250: 4247: 4245: 4242: 4240: 4237: 4235: 4232: 4230: 4227: 4225: 4222: 4220: 4217: 4215: 4212: 4210: 4207: 4205: 4202: 4200: 4197: 4195: 4192: 4190: 4187: 4185: 4182: 4180: 4177: 4175: 4172: 4170: 4167: 4165: 4162: 4160: 4157: 4155: 4152: 4150: 4147: 4145: 4142: 4141: 4138: 4135: 4133: 4130: 4128: 4125: 4123: 4120: 4119: 4117: 4113: 4105: 4102: 4101: 4100: 4097: 4095: 4092: 4091: 4089: 4087: 4083: 4077: 4074: 4072: 4069: 4067: 4064: 4062: 4061:Encephalocele 4059: 4057: 4054: 4053: 4051: 4047: 4044: 4040:Developmental 4038: 4030: 4029: 4028: 4023: 4022: 4017: 4016: 4012: 4004: 4003:Hailey–Hailey 4001: 3997: 3993: 3990: 3988: 3985: 3984: 3983: 3982: 3981:immune system 3978: 3974: 3971: 3970: 3969: 3968: 3964: 3963: 3961: 3957: 3947: 3944: 3942: 3939: 3937: 3934: 3932: 3929: 3927: 3924: 3922: 3919: 3918: 3915: 3912: 3910: 3907: 3903: 3900: 3899: 3898: 3897: 3893: 3891: 3888: 3886: 3883: 3882: 3880: 3876: 3868: 3864: 3861: 3859: 3856: 3855: 3854: 3853: 3849: 3845: 3842: 3841: 3840: 3839: 3835: 3833: 3829: 3828: 3825: 3822: 3820: 3817: 3815: 3812: 3810: 3807: 3805: 3802: 3800: 3797: 3795: 3791: 3788: 3787: 3782: 3779: 3777: 3774: 3770: 3767: 3765: 3762: 3761: 3760: 3757: 3755: 3752: 3750: 3747: 3745: 3741: 3738: 3736: 3733: 3729: 3726: 3724: 3721: 3720: 3719: 3718: 3714: 3712: 3709: 3707: 3704: 3700: 3697: 3696: 3695: 3694: 3690: 3688: 3685: 3681: 3678: 3676: 3673: 3671: 3668: 3667: 3666: 3665: 3661: 3660: 3658: 3657: 3654: 3651: 3649: 3646: 3644: 3641: 3639: 3635: 3632: 3631: 3629: 3627: 3623: 3620: 3618: 3617:keratinopathy 3613: 3609: 3603: 3600: 3598: 3595: 3593: 3590: 3587: 3583: 3580: 3578: 3575: 3574: 3572: 3570: 3566: 3562: 3556: 3552: 3549: 3547: 3544: 3542: 3539: 3537: 3534: 3532: 3529: 3527: 3523: 3520: 3519: 3517: 3515: 3511: 3505: 3502: 3500: 3497: 3495: 3492: 3490: 3486: 3485: 3480: 3477: 3475: 3472: 3471: 3470: 3467: 3466: 3461: 3458: 3456: 3453: 3451: 3448: 3446: 3443: 3442: 3441: 3438: 3437: 3432: 3429: 3427: 3424: 3422: 3419: 3417: 3414: 3412: 3409: 3407: 3404: 3403: 3402: 3399: 3398: 3396: 3392: 3388: 3378: 3375: 3373: 3370: 3368: 3365: 3363: 3360: 3358: 3355: 3353: 3350: 3348: 3345: 3344: 3342: 3338: 3332: 3329: 3328: 3326: 3324: 3320: 3314: 3311: 3309: 3306: 3304: 3301: 3300: 3295: 3292: 3291: 3290: 3287: 3285: 3281: 3278: 3277: 3275: 3273: 3269: 3263: 3260: 3259: 3257: 3255: 3251: 3248: 3246: 3241: 3237: 3234: 3232: 3228: 3224: 3220: 3216: 3209: 3204: 3202: 3197: 3195: 3190: 3189: 3186: 3172: 3169: 3167: 3164: 3163: 3162: 3159: 3157: 3154: 3152: 3149: 3147: 3144: 3142: 3139: 3137: 3134: 3132: 3129: 3128: 3126: 3122: 3116: 3113: 3112: 3110: 3108: 3104: 3099: 3089: 3085: 3082: 3081: 3078: 3070: 3067: 3065: 3062: 3061: 3060: 3057: 3056: 3054: 3052: 3048: 3040: 3036: 3033: 3031: 3027: 3024: 3023: 3022: 3019: 3017: 3014: 3013: 3011: 3009: 3005: 2999: 2996: 2994: 2991: 2989: 2986: 2985: 2983: 2981: 2977: 2974: 2970: 2966: 2958: 2953: 2951: 2946: 2944: 2939: 2938: 2935: 2919: 2918:Pseudo-ainhum 2915: 2912: 2910: 2907: 2905: 2904:Sclerodactyly 2902: 2900: 2897: 2896: 2894: 2890: 2884: 2881: 2880: 2878: 2876: 2872: 2866: 2863: 2861: 2858: 2856: 2853: 2851: 2848: 2846: 2845:Kyrle disease 2843: 2842: 2840: 2838: 2834: 2828: 2825: 2823: 2820: 2818: 2815: 2813: 2810: 2808: 2805: 2803: 2800: 2796: 2793: 2791: 2788: 2787: 2786: 2783: 2781: 2778: 2777: 2775: 2773: 2768: 2764: 2756: 2753: 2751: 2748: 2746: 2743: 2741: 2738: 2736: 2733: 2731: 2728: 2726: 2723: 2722: 2721: 2718: 2717: 2715: 2713: 2708: 2704: 2698: 2695: 2693: 2690: 2688: 2685: 2683: 2680: 2678: 2674: 2673: 2670: 2666: 2663: 2662: 2659: 2656: 2654: 2650: 2649: 2647: 2645: 2644:erythematosus 2639: 2636: 2634: 2628: 2624: 2612: 2609: 2608: 2607: 2606: 2602: 2601: 2599: 2595: 2589: 2586: 2584: 2581: 2579: 2576: 2574: 2571: 2569: 2566: 2564: 2561: 2559: 2556: 2554: 2551: 2550: 2548: 2546: 2542: 2536: 2532: 2529: 2527: 2524: 2522: 2519: 2517: 2514: 2512: 2509: 2507: 2504: 2502: 2499: 2495: 2492: 2490: 2487: 2485: 2482: 2480: 2477: 2475: 2472: 2470: 2467: 2466: 2465: 2462: 2461: 2459: 2457: 2453: 2450: 2448: 2444: 2440: 2434: 2431: 2429: 2426: 2424: 2420: 2419: 2416: 2413: 2411: 2408: 2406: 2403: 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Index

Collagen vascular disease

connective tissue
Specialty
Rheumatology
Edit this on Wikidata
disorder
connective tissue
proteins
elastin
collagen
Tendons
ligaments
skin
cartilage
bone
blood vessels
inflamed
genetic disorders
collagen diseases
Collagen vascular diseases
autoimmune
genetic inheritance
genetic disorders
connective tissue
connective tissues
glycosaminoglycans
collagen
elastin
Marfan syndrome

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