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Mafayle RL, Morales-Betoulle ME, Romero C, Cossaboom CM, Whitmer S, Aguilera CE, Ardaya CA, Zambrana MC, Anajia AD, Loayza NM, Montano AM, Alvis FL, Guzman JR, Martinez SS, De La Vega GA, Ramirez AM, Gutierrez JT, Pinto AJ, Bacci RS, Brignone J, Garcia J, Anez A, Mendez-Rico J, Luz K, Segales A, Cruz
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Chapare virus RNA was detected in the blood, urine, conjunctiva, semen and in broncho-alveolar and nasopharyngeal samples of the infected patients. Those who survived often had prolonged residual neurological symptoms. Viral RNA was detected in survivors up to 170 days after infection and infectious
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After an incubation period of around 9–19 days, initial symptoms include fever, malaise, headache, myalgia, back pain, dizziness, nausea, vomiting and diarrhoea. The disease often progresses to include hemorrhagic and neurological symptoms, such as gingival hemorrhage, anaemia, leukopaenia,
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KM, Valdivia-Cayoja A, Amman BR, Choi MJ, Erickson BR, Goldsmith C, Graziano JC, Joyce A, Klena JD, Leach A, Malenfant JH, Nichol ST, Patel K, Sealy T, Shoemaker T, Spiropoulou CF, Todres A, Towner JS, Montgomery JM (June 2022).
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genome. The two RNA segments are denoted Small (S) and Large (L). It belongs to the New World Clade B lineage of mammarenaviruses and is most closely related to the
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Treatment relies mostly on supportive care and early diagnosis. Specific antiviral therapy for
Chapare virus infection has yet to be properly investigated.
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Delgado S, Erickson BR, Agudo R, Blair PJ, Vallejo E, Albariño CG, Vargas J, Comer JA, Rollin PE, Ksiazek TG, Olson JG, Nichol ST (April 2008).
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and human-to-human transmission of the virus occurred in at least three of the cases which resulted in the death of a
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confusion, seizures, ecchymoses, bleeding from mucous membranes, hemorrhagic shock and multi-organ failure.
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261:. Like other members of the Arenavirus family, the specific zoonotic reservoir and primary transmission
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388:"Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia"
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and convert the names of its constituent species to a binomial format, by appending the name
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Chapare virus was obtained in a semen sample of one patient 86 days after symptom onset.
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463:"Evidence shows human transmission in deadly outbreak of mysterious disease in Bolivia"
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The
Chapare virus is an enveloped virus with a bi-segmented single-stranded ambisense
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548:"Researchers confirm human-to-human transmission of rare virus in Bolivia"
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469:. The American Society of Tropical Medicine and Hygiene. 16 November 2020
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mammarenavirus infection occurred in the village of
Samuzabeti,
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In 2019, nine people became infected with the virus in the
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230:. It was first described after an outbreak of a novel
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International
Committee on Taxonomy of Viruses (ICTV)
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327:Buchmeier, Michael J.; et al. (2 July 2014).
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438:"New kind of killer virus discovered in Bolivia"
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367:to each existing name
265:is suspected to be a
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226:in humans known as
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392:PLOS Pathog
287:Sabia virus
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357:Arenavirus
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293:Symptoms
277:Virology
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169:Synonyms
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240:Bolivia
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267:rodent
263:vector
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68:Realm
61:Virus
679:NCBI
671:TMBT
530:PMID
475:2020
420:PMID
347:2019
666:CoL
592:ICD
520:PMC
512:doi
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