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themselves. "The field of cellular microbiology is a coalescence of two fields: molecular microbiology and cell biology," said
Professor Jacek Hawiger, Chair of Microbiology and Immunology at Vanderbilt University. Particularly in the case of bacterial cells, new technology is starting to be used to
41:
The term "cellular microbiology" was coined by the authors of the book of the same title published in 1996. Cooperation and mutual dependency between microbiology and cell biology had been increasing in the years before that, and the emergence of a new discipline had been suggested and discussed in
67:
and to study them. It has increasingly appeared that applying a purified toxin on a cell does not always provide the complete picture, and that understanding the role of the toxin in pathogenicity, the way the toxin promotes the microbe, the way the toxin is produced and the
116:
inhibit actin polymerization in phagocytes, thereby preventing their uptake. Cellular microbiology tries to understand these processes and how they promote
400:
866:
861:
79:
Numerous eukaryotic cellular processes have been clarified using microbial "tools". A major subject in this category is the
665:
52:
as tools for cell-biology research, and to employ cell-biology methods to understand the pathogenicity of microorganisms.
302:
Ebersbach, G; Jacobs-Wagner, C (Mar 2007). "Exploration into the spatial and temporal mechanisms of bacterial polarity".
269:
393:
83:. Many microbes modify and influence the synthesis or degradation of the host-cell cytoskeleton, in particular the
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137:
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Recently, the field of
Cellular Microbiology has been expanded to incorporate investigation of the
110:). This causes the formation of projections that eventually engulf the bacteria. Bacteria such as
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120:. Other eukaryotic processes that microbes influence and that are researched using microbes are
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reveal a high level of organization within the bacterial cells themselves. For example,
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Dufrêne, YF (Sep 2008). "Towards nanomicrobiology using atomic force microscopy".
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Dramsi S, Cossart P (1998). "Intracellular pathogens and the actin cytoskeleton".
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and atomic force microscopy are both being used to show just how sophisticated
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from microbes have been used for decades to influence processes in
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16:
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NIH Cellular and
Molecular Microbiology (CMM) training program (
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in host cells that otherwise do not internalize microbes (non-
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http://www.mc.vanderbilt.edu/reporter/index.html?ID=988
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879:
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87:network. Intracellular microbes, such as the
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267:http://cellularmicrobiologyprogram.org.au/
180:(1996). "Cellular Microbiology Emerging".
23:bacteria (red) invade cultured human cells
867:Timeline of biology and organic chemistry
265:NHMRC Program in Cellular Microbiology (
15:
408:
336:
154:high-resolution fluorescence microscopy
880:
176:Cossart, P.; Boquet, P.; Normark, S.;
45:Cellular microbiology attempts to use
862:Nobel Prize in Physiology or Medicine
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13:
14:
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245:10.1146/annurev.cellbio.14.1.137
42:several scientific conferences.
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1:
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30:is a discipline that bridges
202:10.1126/science.271.5247.315
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10:
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138:transcriptional regulation
76:counterparts, is crucial.
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316:10.1016/j.tim.2007.01.004
476:Biological engineering
233:Annu Rev Cell Dev Biol
24:
561:Developmental biology
536:Computational biology
516:Cellular microbiology
140:, to name but a few.
72:of the toxin and its
28:Cellular microbiology
19:
781:Reproductive biology
666:Mathematical biology
591:Evolutionary biology
541:Conservation biology
566:Ecological genetics
410:Branches of biology
351:10.1038/nrmicro1948
194:1996Sci...271..315C
130:vesicle trafficking
122:signal transduction
857:History of biology
791:Structural biology
776:Relational biology
601:Generative biology
596:Freshwater biology
272:2019-05-03 at the
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875:
874:
796:Synthetic biology
676:Molecular biology
531:Cognitive biology
339:Nat Rev Microbiol
188:(5247): 315–316.
58:virulence factors
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521:Chemical biology
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274:Wayback Machine
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158:bacterial cells
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239:(1): 137–166.
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104:polymerization
50:microorganisms
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345:(9): 674–80.
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893:Cell biology
888:Microbiology
786:Sociobiology
766:Protistology
731:Photobiology
726:Pharmacology
716:Parasitology
711:Paleontology
691:Neuroscience
671:Microbiology
581:Epidemiology
551:Cytogenetics
515:
511:Cell biology
491:Biosemiotics
481:Biomechanics
461:Biogeography
456:Biochemistry
451:Bacteriology
446:Astrobiology
375:
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310:(3): 101–8.
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178:Rappuoli, R.
171:
145:cell biology
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81:cytoskeleton
78:
70:co-evolution
44:
40:
36:cell biology
32:microbiology
27:
26:
20:
836:Xenobiology
831:Virophysics
801:Systematics
756:Primatology
701:Ornithology
641:Ichthyology
626:Herpetology
621:Gerontology
586:Epigenetics
546:Cryobiology
436:Agrostology
426:Aerobiology
421:Abiogenesis
882:Categories
821:Toxicology
816:Teratology
761:Proteomics
746:Physiology
686:Neontology
651:Lipidology
646:Immunology
616:Geobiology
576:Embryology
556:Dendrology
486:Biophysics
466:Biogeology
164:References
134:cell cycle
126:metabolism
108:phagocytes
93:Salmonella
62:eukaryotic
47:pathogenic
21:Salmonella
736:Phycology
721:Pathology
706:Osteology
696:Nutrition
656:Mammalogy
631:Histology
118:infection
74:host-cell
850:See also
826:Virology
811:Taxonomy
751:Pomology
681:Mycology
611:Genomics
606:Genetics
431:Agronomy
359:18622407
324:17275310
270:Archived
218:32437757
149:microbes
113:Yersinia
99:Shigella
89:bacteria
841:Zoology
571:Ecology
441:Anatomy
367:1525798
253:9891781
210:8553065
190:Bibcode
182:Science
506:Botany
365:
357:
322:
251:
216:
208:
54:Toxins
363:S2CID
214:S2CID
160:are.
85:actin
65:cells
355:PMID
320:PMID
249:PMID
206:PMID
136:and
96:and
56:and
34:and
347:doi
312:doi
241:doi
198:doi
186:271
147:of
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
