477:
549:
2379:"The genetic history of today's European populations is based on continuous migrations over the past 40 000 years. Homo sapiens arrived in Europe from Near East some 42 000 years ago. Like in their African origin, these humans had dark skin but due to variations of their OCA2 gene (causing iris depigmentation) many of them had blue eyes (Figure 2, left)." Figure 2: "Phenotype information was retrieved from supplementary files of the according publications or additionally assessed following the instructions of HirisPlex-S, which is a forensic DNA phenotyping tool based on an array of different marker SNPs providing additional support to the SNPs of the genes SLC24A5, SLC45A2 and OCA2."
501:(also found in green eyes). Amber eyes should not be confused with hazel eyes. Although hazel eyes may contain specks of amber or gold, they usually tend to have many other colors, including green, brown and orange. Also, hazel eyes may appear to shift in color and consist of flecks and ripples, while amber eyes are of a solid gold hue. Even though amber is similar to gold, some people have russet or copper colored amber eyes that are mistaken for hazel, though hazel tends to be duller and contains green with red/gold flecks, as mentioned above. Amber eyes may also contain amounts of very light gold-ish gray.
716:
1449:
1478:. However, there is a study that found that dark-eyed people perform better at "reactive-type tasks", which suggests they may have better reaction times. People with light-colored eyes, however, performed better at so-called "self-paced tasks", which include activities like hitting a golf ball or throwing baseballs. In another study, people with darker eyes performed better at hitting racquetballs. There are also other studies that challenge these findings. According to scientists, more study is needed to verify these results.
966:
1013:(which is not strongly frequency-dependent) rather than Rayleigh scattering (in which shorter wavelengths of light are scattered more). This would be analogous to the change in the color of the sky, from the blue given by the Rayleigh scattering of sunlight by small gas molecules when the sky is clear, to the gray caused by Mie scattering of large water droplets when the sky is cloudy. Alternatively, it has been suggested that gray and blue eyes might differ in the concentration of melanin at the front of the stroma.
997:
410:
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40:
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1242:, the color of the iris is typically blue but can vary from blue to brown. In severe forms of albinism, there is no pigment on the back of the iris, and light from inside the eye can pass through the iris to the front. In these cases, the only color seen is the red from the hemoglobin of the blood in the capillaries of the iris. Such albinos have pink eyes, as do albino rabbits, mice, or any other animal with a total lack of melanin.
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916:
613:
398:
1332:
557:
936:
751:
740:
490:
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524:, also known as lipochrome. Many animals such as canines, domestic cats, owls, eagles, pigeons and fish have amber eyes, whereas in humans this color occurs less frequently. Amber is the third-rarest natural eye color after green and gray, in 5% of the world's population. People with that eye color are found in
1155:
983:
in the United States to be 33.8% for those born from 1936 through 1951, compared with 57.4% for those born from 1899 through 1905. As of 2006, one out of every six
Americans, or 16.6% of the total US population, has blue eyes, including 22.3% of whites. The incidence of blue eyes continues to decline
2880:
Ruiz-Linares, AndrĂ©s; Adhikari, Kaustubh; Acuña-Alonzo, Victor; Quinto-Sanchez, Mirsha; Jaramillo, Claudia; Arias, William; Fuentes, Macarena; Pizarro, MarĂa; Everardo, Paola; de Avila, Francisco; GĂłmez-ValdĂ©s, Jorge; LeĂłn-Mimila, Paola; Hunemeier, TĂĄbita; Ramallo, Virginia; Silva de
Cerqueira, Caio
2491:
Liu, Fan; Wollstein, Andreas; Hysi, Pirro G.; Ankra-Badu, Georgina A.; Spector, Timothy D.; Park, Daniel; Zhu, Gu; Larsson, Mats; Duffy, David L.; Montgomery, Grant W.; MacKey, David A.; Walsh, Susan; Lao, Oscar; Hofman, Albert; Rivadeneira, Fernando; Vingerling, Johannes R.; Uitterlinden, André G.;
568:
and a moderate amount of melanin in the iris' anterior border layer. Hazel eyes often appear to shift in color from a brown to a green. Although hazel mostly consists of brown and green, the dominant color in the eye can either be brown/gold or green. This is why hazel eyes can be mistaken as amber,
405:
Almost all mammals have brown or darkly-pigmented irises. In humans, brown is by far the most common eye color, with approximately 79% of people in the world having it. Brown eyes result from a relatively high concentration of melanin in the stroma of the iris, which causes light of both shorter and
3779:
This may also be a direct counterâmeasure to a short winter photoperiod at high latitudes; blue eyes increase intraocular light scattering and thereby suppress melatonin release from the pineal gland. This may be an adaptive trait to reduce/prevent depression, a condition linked to short day length
2315:
The results of this study suggest that there are indeed sex-specific genetic effects in human pigmentation, with larger effects for darker pigmentation in females compared to males. A plausible cause might be the differentially expressed melanogenic genes in females due to higher oestrogen levels.
1517:
Normal eye colors range from the darkest shades of brown to the lightest tints of blue. To meet the need for standardized classification, at once simple yet detailed enough for research purposes, Seddon et al. developed a graded system based on the predominant iris color and the amount of brown or
3656:
Eiberg, Hans; Troelsen, Jesper; Nielsen, Mette; Mikkelsen, Annemette; Mengel-From, Jonas; Kjaer, Klaus W.; Hansen, Lars (2008). "Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression".
1486:
Iris color can provide a large amount of information about a person, and a classification of colors may be useful in documenting pathological changes or determining how a person may respond to ocular pharmaceuticals. Classification systems have ranged from a basic light or dark description to
3415:
Indeed, among the SNPs tested was rs12913832, a single DNA variation within a regulatory element of HERC2 gene which is associated to blue eye color in humans. This polymorphism, together with the diplotypes obtained from variations of the OCA2 locus (major contributor to the human eye color
1237:
Normally, there is a thick layer of melanin on the back of the iris. Even people with the lightest blue eyes, with no melanin on the front of the iris at all, have dark brown coloration on the back of it, to prevent light from scattering around inside the eye. In those with milder forms of
699:
The green color is caused by the combination of: 1) an amber or light brown pigmentation in the stroma of the iris (which has a low or moderate concentration of melanin) with: 2) a blue shade created by the
Rayleigh scattering of reflected light. Green eyes contain the yellowish pigment
1407:
was born with one blue eye and one green eye, a trait that reportedly was common in his family, suggesting that it was a genetic trait. This anomaly, which film producers thought would be disturbing to film audiences, was "corrected" by having Van Cleef wear brown contact lenses.
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and why amber is often counted as hazel in studies, and vice versa. The combination can sometimes produce a multicolored iris, i.e., an eye that is light brown/amber near the pupil and charcoal or dark green on the outer part of the iris (or vice versa) when observed in sunlight.
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The most important role of melanin in the iris is to protect the eyes from the sun's harmful rays. People with lighter eye colors, such as blue or green, have lessened protection from the sun, and so need greater protection from the sun's rays than those with darker eye colors.
770:. Unlike brown eyes, blue eyes have low concentrations of melanin in the stroma of the iris, which lies in front of the dark epithelium. Longer wavelengths of light tend to be absorbed by the dark underlying epithelium, while shorter wavelengths are reflected and undergo
1357:) is an eye condition in which one iris is a different color from the other (complete heterochromia), or where a part of one iris is a different color from the remainder (partial heterochromia or sectoral heterochromia). It is a result of the relative excess or lack of
2209:"This effect is what may explain the fact that there seem to be comparatively higher frequencies of blue-eyed males than blue-eyed females in populations of European origin such as Iceland , Holland , Australia or Poland , as well as in this study (see Fig. 2)."
821:. The same DNA sequence of the OCA2 gene among blue-eyed people suggests they may have a single common ancestor. The researchers hypothesized that the OCA2 mutation responsible for blue eyes arose in an individual who lived in the northwestern part of the
1473:
Although people with lighter eye color are generally more sensitive to light because they have less pigment in the iris to protect them from sunlight, there is little to no evidence that eye color has a direct impact on vision qualities such as
1004:
Like blue eyes, gray eyes have a dark epithelium at the back of the iris and a relatively clear stroma at the front. One possible explanation for the difference in the appearance of gray and blue eyes is that gray eyes have larger deposits of
2447:
Sulem, Patrick; Gudbjartsson, Daniel F; Stacey, Simon N; Helgason, Agnar; Rafnar, Thorunn; Magnusson, Kristinn P; Manolescu, Andrei; Karason, Ari; et al. (2007). "Genetic determinants of hair, eye and skin pigmentation in
Europeans".
184:
In humans, eye color is a highly sexually dimorphic trait. Several studies have shown that men are more likely to have blue eyes than women, while women are more likely to have darker eye colors (green and brown eyes) than men.
293:. A 2010 study of eye color variation in hue and saturation values using high-resolution digital full-eye photographs found three new loci for a total of ten genes, allowing the explanation of about 50% of eye color variation.
2164:
Martinez-Cadenas, Conrado; Peña-Chilet, Maria; Ibarrola-Villava, Maider; Ribas, Gloria (2013). "Gender is a major factor explaining discrepancies in eye colour prediction based on HERC2/OCA2 genotype and the IrisPlex model".
1117:
can appear purple or violet at certain times, "true" violet-colored eyes occur only due to albinism. Eyes that appear red or violet under certain conditions due to albinism are less than 1 percent of the world's population.
3380:
Keyser, Christine; Bouakaze, Caroline; Crubézy, Eric; Nikolaev, Valery G.; Montagnon, Daniel; Reis, Tatiana; Ludes, Bertrand (2009). "Ancient DNA Provides New
Insights into the History of South Siberian Kurgan People".
1250:
due to lack of iridial pigmentation. The ocular albino also lacks normal amounts of melanin in the retina as well, which allows more light than normal to reflect off the retina and out of the eye. Because of this, the
96:(located on the back of the iris), the melanin content within the iris stroma (located at the front of the iris), and the cellular density of the stroma. The appearance of blue, green, and hazel eyes results from the
2254:
Hernando, Barbara; Ibarrola-Villava, Maider; Fernandez, Lara P.; Peña-Chilet, Maria; Llorca-Cardeñosa, Marta; Oltra, Sara S.; Alonso, Santos; Boyano, Maria
Dolores; Martinez-Cadenas, Conrado; Ribas, Gloria (2016).
1456:
The limbal ring is also a feature of the iris contributing to eye color, appearing as a darkened, occasionally black region encircling the iris resulting from a manifestation of the optical properties of the
837:
research has identified human remains much older than the
Neolithic period with the OCA2 mutation for blue eyes. It is now believed that the OCA2 allele dates back to the recent migration of modern humans
2244:"Several research groups have demonstrated that females have a darker eye color than males, given the same SNP profile (Martinez-Cadenas et al., 2013; Pietroni et al., 2014; Pospiech et al., 2016)."
1514:
in the first half of the 20th century. The scale consists of 20 colors ranging from light blue to dark brown-black, corresponding to natural eye colors caused by the amount of melanin in the iris:
367:
17% of children experienced a change of eye color from early childhood to adulthood, and of those children, 50% of developed lighter eyes as they got older. The other 50% developed darker eyes.
370:
Generally, children with hazel and light brown eyes tended to experience a lightening of their eye color by adulthood. Children with green eyes often experienced a darkening of their eye color.
583:
Around 18% of the US population and 5% of the world population have hazel eyes. 55.2% of
Spanish subjects in a series of 221 photographs were judged to have hazel eyes. Hazel eyes are found in
134:
The genetics and inheritance of eye color in humans is complicated. As of 2010, as many as 16 genes have been associated with eye color inheritance. Some of the eye-color genes include
3701:
476:
2316:
These sex-specific genetic effects would help explain the presence of darker eye and skin pigmentation in females, as well as the well-known higher melanoma risk displayed by males.
1078:, it is also possible to have two different eye colors. This occurs in humans and certain breeds of domesticated animals and affects less than 1 percent of the world's population.
2698:
4133:
1522:. Green irises, for example, have some yellow and the blue structural color. Brown irises contain more or less melanin. Some eyes have a dark ring around the iris, called a
874:
It has been proposed that blue eyes may have been adaptive to shorter day lengths at higher latitudes, as blue eyes increase inferocular light scattering, which suppresses
473:. Light brown eyes bordering amber and hazel coloration are common in Europe, but can also be observed in East Asia and Southeast Asia, though are uncommon in the region.
3886:
4982:
German EJ, Hurst MA, Wood D, Gilchrist J (1998). "A novel system for the objective classification of iris colour and its correlation with response to 1% tropicamide".
3646:"Everyone with blue eyes alive today can trace their ancestry back to one person who probably lived about 10,000 years ago in the Black Sea region, a study has found."
215:
There is evidence that as many as 16 different genes could be responsible for eye color in humans; however, the main two genes associated with eye color variation are
1134:(ARMD) than those with darker iris color; lighter eye color is also associated with an increased risk of ARMD progression. A gray iris may indicate the presence of a
1945:
Duffy, David L.; Montgomery, Grant W.; Chen, Wei; Zhao, Zhen Zhen; Le, Lien; James, Michael R.; Hayward, Nicholas K.; Martin, Nicholas G.; Sturm, Richard A. (2007).
1553:
depends on viewing conditions (e.g., the amount and kind of illumination, as well as the hue of the surrounding environment), so does the perception of eye color.
4606:
Imesch PD, Wallow IH, Albert DM (1997). "The color of the human eye: a review of morphologic correlates and of some conditions that affect iridial pigmentation".
5030:
2947:; Gillespie, Nathan A.; Ewen, Kelly R.; Jewell, Mary; Liew, Yew Wah; Hayward, Nicholas K.; Sturma, Richard A.; Trenta, Jeffrey M.; Martina, Nicholas G. (2004).
1419:
affecting the development of one eye, possibly through some sort of genetic mutation. Occasionally, heterochromia can be a sign of a serious medical condition.
377:
experienced an eye color change during the same period, with most developing lighter eyes, relative to their original color at the time of their child's birth.
3733:"The evolution of human skin pigmentation: A changing medley of vitamins, genetic variability, and <scp>UV</scp> radiation during human expansion"
1998:
1142:
has been found in those with blue, green or gray eyes. However, a study in 2000 suggests that people with dark brown eyes are at increased risk of developing
2389:
Kayser, Manfred; Liu, Fan; Janssens, A. Cecile J.W.; Rivadeneira, Fernando; Lao, Oscar; Van Duijn, Kate; Vermeulen, Mark; Arp, Pascal; et al. (2008).
1110:", in which the very bright light from a flash reflects off the retina, which is abundantly vascular, causing the pupil to appear red in the photograph.
150:
has been shown to be incorrect. The genetics of eye color are so complex that almost any parent-child combination of eye colors can occur. However, OCA2
4100:
4341:
Rafnsson V, Hrafnkelsson J, Tulinius H, Sigurgeirsson B, Olafsson JH (2004). "Risk factors for malignant melanoma in an
Icelandic population sample".
1518:
yellow pigment present. There are three pigment colors that determine, depending on their proportion, the outward appearance of the iris, along with
1461:. Limbal rings are not present in all individuals, and their thickness and prominence may correlate with health or youthfulness, and contributes to
5102:
1434:, can also cause increased pigmentation in one eye. On occasion, a difference in eye color is caused by blood staining the iris after injury.
988:, 56% have blue/green eyes. In a series of 221 photographs of Spanish subjects, 16.3% of the subjects were determined to have blue-gray eyes.
3709:
1184:
in cells. Instead, the copper accumulates in the liver and in other tissues, including the iris of the eye. This results in the formation of
965:
3629:
2091:
1916:
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detailed gradings employing photographic standards for comparison. Others have attempted to set objective standards of color comparison.
5137:
5055:
Piquet-Thepot M.-M. - Bulletins et Mémoires de la Société d'anthropologie de Paris, XII° Série, tome 3 fascicule 3, pg. 207,208 - (1968)
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189:
is therefore a major factor in the expression of eye color genotypes. One study suggested that women's higher levels of the sex hormone
4141:
3430:
4014:
3200:
Hawkins TA, Stewart WC, McMillan TA, Gwynn DR (1994). "Analysis of diode, argon, and Nd: YAG peripheral iridectomy in cadaver eyes".
4082:
2257:"Sex-specific genetic effects associated with pigmentation, sensitivity to sunlight, and melanoma in a population of Spanish origin"
979:
Approximately 8% to 10% of the global population have blue eyes. A 2002 study found that the prevalence of blue eye color among the
200:
technology have revealed some of the history of eye color in Europe. Through the analysis of ancient DNA, a 2020 study published in
2883:"Admixture in Latin America: Geographic Structure, Phenotypic Diversity and Self-Perception of Ancestry Based on 7,342 Individuals"
497:
Amber eyes are a solid color with a strong yellowish/golden and russet/coppery tint, which may be due to the yellow pigment called
1412:, on the other hand, had the appearance of different eye colors due to an injury that caused one pupil to be permanently dilated.
949:
277:, where they may influence the expression of the gene product, which in turn affects pigmentation. A specific mutation within the
4376:
Stang A, Ahrens W, Anastassiou G, Jöckel KH (2003). "Phenotypical characteristics, lifestyle, social class and uveal melanoma".
1047:
appears with gray eyes (γλαÏ
ÎșῶÏÎčÏ). Under magnification, gray eyes exhibit small amounts of yellow and brown color in the iris.
2988:
Albert, Daniel M; Green, W Richard; Zimbric, Michele L; Lo, Cecilia; Gangnon, Ronald E; Hope, Kirsten L; Gleiser, Joel (2003).
839:
209:
1229:
is a congenital condition characterized by an extremely underdeveloped iris, which appears absent on superficial examination.
520:(called xanthophores) located in the iris stroma. In humans, yellowish specks or patches are thought to be due to the pigment
177:
or SNPs. The total number of genes that contribute to eye color is unknown, but there are a few likely candidates. A study in
4826:
Miller, L. K.; Rowe, P. J.; Lund, J. (August 1992). "Correlation of eye color on self-paced and reactive motor performance".
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181:(2009) found that it was possible to predict eye color with more than 90% accuracy for brown and blue using just six SNPs.
5165:
2718:
3838:
3821:
2680:
250:. (The name of the gene is derived from the disorder it causes, oculocutaneous albinism type II.) Different SNPs within
3518:
155:
5034:
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1396:
can have two different colored eyes just like any two siblings canâbecause each cell has different eye color genes. A
3361:
1772:
Sturm R.A. & Larsson M., Genetics of human iris colour and patterns, Pigment Cell
Melanoma Res, 22:544-562, 2009.
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915:
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medium of the stroma. This is the same scattering that accounts for the blue appearance of the sky. The result is a "
3852:
2029:
4928:
Crowe, M.; O'Connor, D. (October 2001). "Eye colour and reaction time to visual stimuli in rugby league players".
196:
People of European descent show the greatest variety in eye color of any population worldwide. Recent advances in
4298:; McCarty, Catherine A (2003). "Iris colour, ethnic origin and progression of age-related macular degeneration".
3281:
Muiños DĂaz, Yerena; Saornil, Maria A.; Almaraz, Ana; Muñoz-Moreno, Mari F.; GarcĂa, Ciro; Sanz, Ruperto (2009).
3599:
3537:"Is there any difference in the photobiological properties of melanins isolated from human blue and brown eyes?"
2049:
Grant MD, Lauderdale DS (2002). "Cohort effects in a genetically determined trait: eye colour among US whites".
5017:
2770:
Oliphant LW (1981). "Crystalline pteridines in the stromal pigment cells of the iris of the great horned owl".
1507:
1300:
352:
Blue eyes with a brown spot, green eyes, and gray eyes are caused by an entirely different part of the genome.
174:
4506:
de la Maza, Maite Sainz; Tauber, Joseph; Foster, C. Stephen (2012). "Noninflammatory Diseases of the Sclera".
1947:"A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation"
4110:
4262:"Melanins: Skin Pigments and Much MoreâTypes, Structural Models, Biological Functions, and Formation Routes"
173:. These genes are sought by studying small changes in the genes themselves and in neighboring genes, called
4747:"Put a (Limbal) Ring on It: Women Perceive Men's Limbal Rings as a Health Cue in Short-Term Mating Domains"
3416:
variation) showed that at least 60% of the ancient Siberian specimens under study had blue (or green) eyes.
1917:"Eye color definition â Medical Dictionary definitions of popular medical terms easily defined on MedTerms"
1642:"Characterization of melanins in human irides and cultured uveal melanocytes from eyes of different colors"
882:, perhaps reducing psychological depression (which is linked to the short day length of higher latitudes).
3996:, Volumes 16â17 By SociĂ©tĂ© de statistique, d'histoire et d'archĂ©ologie de Marseille et de Provence p. 273
4539:
Wheatley, TJ (2006). "Upper gastrointestinal surgery". In Kingsnorth, Andrew N; Majid, Aljafri A (eds.).
4164:
1403:
There are many other possible reasons for having two different-colored eyes. For example, the film actor
391:
2391:"Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene"
3853:"Blue eyes are increasingly rare in America - Americas - International Herald Tribune (Published 2006)"
2159:
2157:
2155:
2153:
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733:
17:
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3822:"Distribution of Bodily Characters. Pigmentation, the Pilous System, and Morphology of the Soft Parts"
3283:"Iris color: validation of a new classification and distribution in a Spanish population-based sample"
1050:
Gray is the second-rarest natural eye color after green, with 3% of the world's population having it.
3336:
1185:
1159:
817:
815:
located a single mutation that causes the phenomenon of blue eyes. The research was published in the
2949:"A genome scan for eye color in 502 twin families: most variation is due to a QTL on chromosome 15q"
2150:
1529:
Eye color in non-human animals is regulated differently. For example, instead of blue as in humans,
5219:
4105:
1491:
812:
285:
expression, is partly responsible for blue eyes. Other genes implicated in eye color variation are
115:
The brightly colored eyes of many bird species result from the presence of other pigments, such as
4015:
http://www.perseus.tufts.edu/hopper/text?doc=Perseus%3Atext%3A1999.01.0133%3Abook%3D1%3Acard%3D206
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which accounts for the blue sky. Neither blue nor green pigments are present in the human iris or
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vary: it is sometimes considered to be synonymous with light brown or gold, as in the color of a
93:
5194:
3073:"Induction of tyrosinase gene transcription in human iris organ cultures exposed to latanoprost"
4419:
Cumming RG, Mitchell P, Lim R (2000). "Iris color and cataract: The Blue Mountains Eye Study".
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1920:
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In many parts of the world, it is nearly the only iris color present. Brown eyes are common in
5186:
Ask a Geneticist: If both parents have blue eyes, how could they have a child with brown eyes?
3993:
2220:
1400:
can have two different colored eyes if the DNA difference happens to be in an eye-color gene.
364:
found that eye color may be subject to change in infancy, and from adolescence to adulthood.
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4294:
Nicolas, Caroline M; Robman, Luba D; Tikellis, Gabriella; Dimitrov, Peter N; Dowrick, Adam;
3794:
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2494:"Digital Quantification of Human Eye Color Highlights Genetic Association of Three New Loci"
2110:
Liu, Fan; Van Duijn, Kate; Vingerling, Johannes R.; Hofman, Albert; Uitterlinden, André G.;
1687:
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Wielgus AR, Sarna T (2005). "Melanin in human irides of different color and age of donors".
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Rowe, P. J.; Evans, P. (August 1994). "Ball color, eye color, and a reactive motor skill".
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Hammond BR, Fuld K, Snodderly DM (1996). "Iris color and macular pigment optical density".
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Cavalli-Sforza, Luigi Luca; Cavalli-Sforza, Luca; Menozzi, Paolo; Piazza, Alberto (1994).
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may appear red under certain lighting conditions owing to the extremely low quantities of
8:
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An example of sectoral heterochromia. The subject has a blue iris with a brown section.
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An example of complete heterochromia. The subject has one brown eye and one hazel eye.
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Percentage of dark eyes among British military recruits in the 19th century by region
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2477:
2078:
1448:
1415:
Another hypothesis about heterochromia is that it can result from a viral infection
5078:
4991:
4937:
4914:
4886:
4835:
4758:
4717:
4707:
4665:
4656:
Hejkal TW, Camras CB (1999). "Prostaglandin analogs in the treatment of glaucoma".
4615:
4544:
4511:
4475:
4467:
4428:
4405:
4385:
4350:
4307:
4273:
4224:
4176:
3929:
3921:
3760:
3744:
3686:
3666:
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3548:
3475:
3463:
3390:
3294:
3252:
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3172:
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3084:
3045:
3001:
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2912:
2894:
2829:
2799:
2779:
2744:
2552:
2515:
2505:
2457:
2410:
2402:
2344:
2296:
2278:
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2182:
2174:
2129:
2058:
2013:
1966:
1958:
1876:
1821:
1794:
1759:
1737:
1722:(2005). "Separating reflections in human iris images for illumination estimation".
1653:
1606:
1567:
1519:
1506:
to establish the eye color of an individual. It was created by the anthropologists
1196:
Eye color outside of the iris may also be symptomatic of disease. Yellowing of the
1114:
783:
693:
627:
509:
267:
243:
109:
54:
2841:
1812:
Oliphant LW (1987). "Pteridines and purines as major pigments of the avian iris".
885:
Blue eyes are predominant in northern and eastern Europe, particularly around the
5169:
5097:
4548:
4086:
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3522:
3434:
3351:
2899:
2722:
2702:
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in the stroma, so that the light that is reflected from the epithelium undergoes
980:
890:
805:
797:
have shown that men are substantially more likely to have blue eyes than women.
665:
326:
Affects function of OCA2, with a specific mutation strongly linked to blue eyes.
147:
112:, which depends on the lighting conditions, especially for lighter-colored eyes.
105:
4515:
4389:
4354:
2163:
647:
Green eyes probably result from the interaction of multiple variants within the
5224:
5162:
4712:
3887:"Don't it make my blue eyes brown Americans are seeing a dramatic color change"
3298:
3177:
3160:
3089:
3072:
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2948:
2715:
2406:
1719:
1458:
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935:
779:
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97:
85:
78:
66:
5096:
Seddon, JM; CR Sahagian; RJ Glynn; RD Sperduto; ES Gragoudas (1 August 1990).
4941:
4890:
4669:
3825:
3670:
3394:
2879:
2273:
2134:
2115:
2062:
2017:
5203:
5067:"Contribution Ă l'anthropologie des Corses: Anthropologie de la tĂȘte (suite)"
4949:
4898:
4847:
4839:
4802:
4763:
4746:
4589:
3910:"Prediction of eye color in the Slovenian population using the IrisPlex SNPs"
3864:
3756:
3306:
2944:
2908:
2833:
2358:
2292:
2196:
2096:
1618:
1475:
1404:
1130:
Those with lighter iris color have been found to have a higher prevalence of
1020:
800:
The inheritance pattern followed by blue eyes was previously assumed to be a
759:
537:
517:
228:
5082:
4693:"Preliminary evidence that the limbal ring influences facial attractiveness"
4471:
3925:
3515:
3282:
2817:
2607:
2253:
2222:
Forensic DNA Analysis: Technological Development and Innovative Applications
1847:
5214:
4957:
4772:
4731:
4677:
4489:
4440:
4397:
4362:
4319:
4295:
4238:
3943:
3908:
Kastelic, V; PoĆpiech, E; Draus-Barini, J; Branicki, W; DrobniÄ, K (2013).
3774:
3678:
3487:
3402:
3314:
3256:
3186:
3142:
3098:
3057:
3015:
2974:
2926:
2735:
Oliphant LW (1987). "Observations on the pigmentation of the pigeon iris".
2608:
Blue eyes in lemurs and humans: same phenotype, different genetic mechanism
2529:
2469:
2424:
2366:
2310:
2204:
2143:
2070:
2025:
1980:
1890:
1658:
1641:
1626:
1550:
1495:
1036:
996:
902:
894:
879:
533:
513:
430:
409:
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suggested that the common gene for blue eye color likely originated in the
31:
5115:
5003:
4906:
4855:
4640:
4627:
4278:
4261:
3570:
3446:
3353:
The Races of Britain. A contribution to the anthropology of Western Europe
3264:
3221:
3033:
2990:"Iris melanocyte numbers in Asian, African American, and Caucasian irides"
2791:
2756:
2564:
1833:
1741:
1667:
1255:
is much more pronounced in albino individuals, and this can emphasize the
1146:
and therefore should protect their eyes from direct exposure to sunlight.
254:
are strongly associated with blue and green eyes as well as variations in
39:
4340:
4229:
4212:
3791:
3552:
1881:
1864:
1724:
Tenth IEEE International Conference on Computer Vision (ICCV'05) Volume 1
1717:
1577:
1523:
1499:
1443:
1427:
1409:
1028:
941:
834:
744:
681:
588:
529:
197:
3535:
Menon IA, Basu PK, Persad S, Avaria M, Felix CC, Kalyanaraman B (1987).
1798:
1377:
content. A number of causes are responsible, including genetic, such as
1154:
3748:
3479:
3213:
2783:
2461:
2283:
2187:
1562:
1303: in this section. Unsourced material may be challenged and removed.
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1040:
898:
886:
763:
701:
658:
521:
498:
470:
434:
341:
290:
263:
128:
124:
70:
3464:"Genetic determinants of hair, eye and skin pigmentation in Europeans"
2492:
Martin, Nicholas G.; Hammond, Christopher J.; Kayser, Manfred (2010).
2349:
2332:
1212:. A blue coloration of the sclera may also be symptomatic of disease.
808:, meaning that it is controlled by the interactions of several genes.
504:
The eyes of some pigeons contain yellow fluorescing pigments known as
4691:
Darren Peshek; Negar Semmaknejad; Donald Hoffman; Pete Foley (2011).
4594:
4577:
3607:
3280:
1572:
1533:
1209:
1205:
1032:
906:
875:
830:
822:
775:
596:
505:
466:
453:. Light or medium-pigmented brown eyes can also be commonly found in
438:
422:
255:
205:
178:
116:
74:
5095:
3907:
1278:
88:
varies from light brown to black, depending on the concentration of
3603:
3034:"Iris color and intraocular pressure: the Blue Mountains Eye Study"
2116:"Eye color and the prediction of complex phenotypes from genotypes"
1962:
1530:
1339:
1239:
1226:
1221:
1201:
1143:
1006:
985:
926:
577:
458:
450:
190:
51:
1426:, which can result in a number of heterochromatic traits, such as
5020:
Technical report 1495, University of WisconsinâMadison, Dec 2003.
2943:
Zhu, Gu; Evans, David M.; Duffy, David L.; Montgomery, Grant W.;
1374:
1366:
1358:
1135:
1099:
1017:
767:
677:
654:
442:
374:
331:
313:
286:
89:
58:
3994:
Provincia: bulletin trimestriel de la Société de Statistique ...
3841:. Adelaidenow.com.au (11 January 2008). Retrieved on 2011-12-23.
2684:
1640:
Prota G, Hu DN, Vincensi MR, McCormick SA, Napolitano A (1998).
1331:
1188:, which are dark rings that encircle the periphery of the iris.
842:
roughly 50,000 years ago, and entered Europe from western Asia.
397:
239:
208:
and arrived in Europe around 42,000 years ago, after the exodus
2446:
1906:. Sciencedaily.com (22 February 2007). Retrieved on 2011-12-23.
1370:
1197:
1177:
1044:
922:
850:
826:
794:
584:
556:
525:
512:
are thought to be due to the presence of the pteridine pigment
454:
446:
418:
120:
3655:
3071:
Lindsey JD, Jones HL, Hewitt EG, Angert M, Weinreb RN (2001).
4293:
4009:
3379:
3032:
Mitchell R, Rochtchina E, Lee A, Wang JJ, Mitchell P (2003).
956:
855:
804:
trait, however, eye color inheritance is now recognized as a
750:
739:
489:
321:
223:
142:
5071:
Bulletins et Mémoires de la Société d'anthropologie de Paris
4375:
2388:
2109:
1863:
White, Désirée; Rabago-Smith, Montserrat (14 October 2010).
1086:
707:
3199:
2816:
Lefohn A, Budge B, Shirley P, Caruso R, Reinhard E (2003).
2685:
SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 1; SHEP1 - 227220
2543:
Bito, LZ (1997). "Eye Color Changes Past Early Childhood".
1102:, allowing the blood vessels to show through. In addition,
758:
There is no blue pigmentation either in the iris or in the
649:
462:
307:
217:
170:
136:
43:
The irises of human eyes exhibit a wide spectrum of colours
3785:
3525:. allaboutgenes.weebly.com. Retrieved on 8 September 2016.
2490:
1999:"Eye colour: portals into pigmentation genes and ancestry"
595:, and have also been observed to be very common among the
193:
may explain why women tend to have darker eyes than men.
30:"Iris color" redirects here. For the shade of purple, see
5135:
3031:
346:
Associated with differences between blue and green eyes.
336:
Associated with differences between blue and green eyes.
242:), when in a variant form, causes the pink eye color and
186:
62:
4981:
3117:"Race, iris color, and age-related macular degeneration"
3070:
2815:
1639:
1373:. This uncommon condition usually results due to uneven
845:
Eiberg and colleagues suggested in a study published in
3583:
3158:
2942:
2588:
1944:
829:
sometime between 6,000 and 10,000 years ago during the
169:
Eye color is an inherited trait determined by multiple
4505:
3962:"Are gray eyes the same as blue in terms of genetics?"
3161:"Iris color as a prognostic factor in ocular melanoma"
3114:
2578:
2576:
2574:
1172:
involves a mutation of the gene coding for the enzyme
4213:"Genotypeâphenotype associations and human eye color"
3534:
2994:
Transactions of the American Ophthalmological Society
2725:. Eyecarecontacts.com. Retrieved on 23 December 2011.
1865:"Genotypeâphenotype associations and human eye color"
653:
and other genes. They may have been present in south
146:. The earlier belief that blue eye color is a simple
5172:. Edromanguitars.com. Retrieved on 23 December 2011.
3437:. Eyedoctorguide.com. Retrieved on 23 December 2011.
3242:
2987:
5098:"Evaluation of an iris color classification system"
4791:"The Claim: Eye Color Can Have an Effect on Vision"
4175:(Second ed.). Academic Press. pp. 24â26.
3966:
Understanding Genetics: Human Health and the Genome
2606:Brenda J Bradley, Anja Pedersen, Nicholas I Mundy:
2571:
2331:Hanel, Andrea; Carlberg, Carsten (September 2020).
1204:, and may be symptomatic of liver diseases such as
1113:Although the deep blue eyes of some people such as
688:, green eyes are most common among those of recent
4605:
4418:
3793:
3630:"How one ancestor helped turn our brown eyes blue"
3447:Why Do Europeans Have So Many Hair and Eye Colors?
3428:Blue Eyes Versus Brown Eyes: A Primer on Eye Color
316:producing cells. Central importance to eye color.
4927:
4744:
4211:White, Désirée; Rabago-Smith, Montserrat (2010).
4210:
3462:Sulem, P.; Gudbjartsson, D.; et al. (2007).
3461:
3449:. Cogweb.ucla.edu. Retrieved on 23 December 2011.
3159:Regan S, Judge HE, Gragoudas ES, Egan KM (1999).
2818:"An Ocularist's Approach to Human Iris Synthesis"
1862:
871:with subsequent reduction in melanin production.
859:gene, which is hypothesized to interact with the
390:"Brown eyes" redirects here. For other uses, see
5201:
5103:Investigative Ophthalmology & Visual Science
4453:
3702:"Blue eyes result of ancient genetic 'mutation'"
3115:Frank RN, Puklin JE, Stock C, Canter LA (2000).
2696:Howard Hughes Medical Institute: Ask A Scientist
2092:"DNA test for eye colour could help fight crime"
1848:"Phenotypes and Genotypes for human eye colors."
1422:A common cause in females with heterochromia is
1361:within an iris or part of an iris, which may be
1246:defects can almost always be observed during an
1232:
732:"Blue eyes" redirects here. For other uses, see
100:of light in the stroma, a phenomenon similar to
4131:
3693:
2048:
1919:. Medterms.com. 29 October 2003. Archived from
1904:No Single Gene For Eye Color, Researchers Prove
1430:. Trauma and certain medications, such as some
793:eye color. Studies from various populations in
786:that varies with external lighting conditions.
4825:
4125:
4089:. Albinism.org. Retrieved on 23 December 2011.
3600:"Genetic mutation makes those brown eyes blue"
2657:Biochromy: Natural Coloration of Living Things
1858:
1856:
1689:Biochromy: Natural Coloration of Living Things
1200:(the "whites of the eyes") is associated with
5138:"Subspecies comparison of the Genus: Corucia"
5064:
5018:Quantification and Correction of Iris Color."
4738:
3968:. Stanford School of Medicine. Archived from
3955:
3953:
3649:
2660:. University of California Press. p. 9.
2330:
1996:
1850:Athro Limited website. Retrieved 10 May 2006.
676:. Around 8â10% of men and 18â21% of women in
373:It was also found that 11% of the children's
4788:
4655:
4098:
3780:(Higuchi et al., 2007; Lucock et al., 2021).
1596:
4284:Eye color change and the affecting factors.
3959:
3878:
3814:
3737:American Journal of Biological Anthropology
3027:
3025:
2769:
2734:
1853:
1811:
1191:
161:, explains most human eye-color variation.
4162:
3950:
2705:. Hhmi.org. Retrieved on 23 December 2011.
2218:
1481:
599:speaking populations of northern Germany.
4977:
4975:
4876:
4762:
4721:
4711:
4501:
4499:
4479:
4447:
4277:
4228:
3933:
3764:
3699:
3560:
3373:
3356:. Michigan State University. p. 39.
3276:
3274:
3176:
3132:
3088:
3005:
2964:
2916:
2898:
2811:
2809:
2519:
2509:
2414:
2348:
2300:
2282:
2272:
2186:
2133:
1970:
1880:
1805:
1731:
1681:
1679:
1677:
1657:
1319:Learn how and when to remove this message
974:, also known as the blue-eyed black lemur
766:is brownish black due to the presence of
4538:
4334:
4156:
4073:
3796:The History and Geography of Human Genes
3593:
3591:
3457:
3455:
3368:the Saxons...being very often hazel-eyed
3154:
3152:
3110:
3108:
3022:
2442:
2440:
2438:
2436:
2434:
2326:
2324:
2167:Forensic Science International: Genetics
2044:
2042:
1992:
1990:
1452:Light brown iris with a dark limbal ring
1447:
1338:
1330:
1153:
1094:The eyes of people with severe forms of
1085:
1062:
995:
811:In 2008, a team of researchers from the
749:
738:
714:
706:
555:
547:
488:
475:
408:
396:
164:
38:
5089:
4412:
4287:
4163:Fertl, Dagmar; Rosel, Patricia (2009).
3236:
1940:
1938:
1780:
1778:
1121:
1058:
564:Hazel eyes are due to a combination of
355:
14:
5202:
5065:Piquet-Thepot, M.-M. (26 March 1968).
4972:
4599:
4496:
4259:
3884:
3850:
3730:
3597:
3349:
3271:
2938:
2936:
2806:
2649:
2647:
2382:
2333:"Skin colour and vitamin D: An update"
1713:
1711:
1709:
1674:
1590:
1067:Two different eye colors are known as
1016:Gray eyes can also be found among the
680:and 6% of men and 17% of women in the
4821:
4819:
4784:
4782:
4369:
4055:"The World's Population By Eye Color"
4049:
4047:
3998:l'iris gris est celui des chaouias...
3588:
3528:
3452:
3149:
3105:
2624:
2620:
2618:
2616:
2431:
2321:
2225:. Apple Academic Press. p. 207.
2039:
1987:
1840:
1785:Mason, Clyde W. (1924). "Blue Eyes".
1784:
1718:Huiqiong Wang; Lin, S.; Xiaopei Liu;
127:. Humans and other animals have many
5136:Jones, S.L.; Schnirel, B.L. (2006).
4789:O'Connor, Anahad (19 January 2009).
4134:"Elizabeth Taylor: Beautiful Mutant"
3724:
3700:Highfield, Roger (30 January 2008).
2594:
2582:
2557:10.1001/archopht.1997.01100150661017
2542:
2247:
2212:
1935:
1775:
1633:
1301:adding citations to reliable sources
1272:
606:
69:and the frequency-dependence of the
5010:
4684:
3885:Belkin, Douglas (17 October 2006).
3851:Belkin, Douglas (18 October 2006).
3337:"Where are hazel eyes most common?"
2933:
2681:Online Mendelian Inheritance in Man
2653:
2644:
1706:
1685:
1468:
1180:within the liver from entering the
1149:
413:A light brown iris with limbal ring
406:longer wavelengths to be absorbed.
84:In humans, the pigmentation of the
27:Polygenic phenotypic characteristic
24:
4816:
4779:
4181:10.1016/b978-0-12-373553-9.00006-7
4101:"HOW TO: Avoid the red eye effect"
4044:
3598:Bryner, Jeanna (31 January 2008).
2749:10.1111/j.1600-0749.1987.tb00414.x
2627:"Which Eye Colors Are the Rarest?"
2613:
1826:10.1111/j.1600-0749.1987.tb00401.x
1692:. University of California Press.
380:
25:
5236:
5179:
4590:Ocular Manifestations of Albinism
4541:Fundamentals of Surgical Practice
4421:American Journal of Ophthalmology
4132:Palmer, Roxanne (25 March 2005).
3287:European Journal of Ophthalmology
1081:
270:. The polymorphisms may be in an
5156:
5129:
5058:
4312:10.1046/j.1442-9071.2003.00711.x
4099:Dave Johnson (16 January 2009).
3731:Lucock, Mark D. (25 June 2022).
1611:10.1111/j.1600-0749.2005.00268.x
1277:
1262:
1132:age-related macular degeneration
1053:
964:
948:
934:
914:
611:
508:. The bright yellow eyes of the
5049:
5031:"Martin-Schulz Eye Color Chart"
5023:
4921:
4870:
4649:
4634:
4582:
4565:
4532:
4454:McDonnell G, Esmonde T (1999).
4253:
4204:
4092:
4019:
4002:
3984:
3901:
3844:
3832:
3622:
3577:
3509:
3440:
3421:
3343:
3329:
3193:
3064:
2981:
2873:
2848:
2763:
2728:
2708:
2689:
2674:
2600:
2536:
2484:
2103:
2085:
1909:
1897:
1536:eye color in the skink species
1288:needs additional citations for
175:single-nucleotide polymorphisms
57:determined by two factors: the
4173:Encyclopedia of Marine Mammals
3800:. Princeton University Press.
1997:Sturm RA, Frudakis TN (2004).
1766:
1437:
889:. Blue eyes are also found in
664:Green eyes are most common in
528:, and in fewer numbers in the
13:
1:
4996:10.1016/S0275-5408(97)00070-7
4620:10.1016/S0039-6257(97)80018-5
4433:10.1016/S0002-9394(00)00479-7
3050:10.1016/S0002-9394(02)01967-0
2654:Fox, Denis Llewellyn (1979).
2219:Pilli, E.; Berti, A. (2021).
1787:Journal of Physical Chemistry
1726:. pp. 1691â1698 Vol. 2.
1686:Fox, Denis Llewellyn (1979).
1583:
1233:Ocular albinism and eye color
959:known to be born in captivity
833:period. However, more recent
572:Definitions of the eye color
5195:Eye Color and Human Diseases
4549:10.1017/CBO9780511545740.013
4300:Clin. Experiment. Ophthalmol
3127:: 109â15, discussion 115â7.
2900:10.1371/journal.pgen.1004572
2511:10.1371/journal.pgen.1000934
2179:10.1016/j.fsigen.2013.03.007
1542:is black, and the autosomal
1027:in Northwest Africa, in the
984:among American children. Of
849:that a mutation in the 86th
281:gene, a gene that regulates
227:, and both are localized in
7:
5016:Fan S, Dyer CR, Hubbard L.
4930:Perceptual and Motor Skills
4879:Perceptual and Motor Skills
4828:Perceptual and Motor Skills
4641:Biography for Lee Van Cleef
4516:10.1007/978-1-4419-6502-8_8
4390:10.1076/opep.10.5.293.17319
4355:10.1016/j.ypmed.2004.03.027
2173:(4). Elsevier BV: 453â460.
1556:
1215:
1138:, and an increased risk of
622:may have misleading content
392:Brown eyes (disambiguation)
10:
5241:
4745:Brown M, Sacco DF (2018).
4713:10.1177/147470491100900201
3516:"OCA2: The Gene for Color"
3299:10.1177/112067210901900427
3178:10.1001/archopht.117.6.811
3090:10.1001/archopht.119.6.853
2966:10.1375/136905204323016186
2407:10.1016/j.ajhg.2007.10.003
2261:Biology of Sex Differences
2114:; Kayser, Manfred (2009).
1441:
1266:
1219:
734:Blue eyes (disambiguation)
731:
696:ancestry, with about 16%.
389:
29:
5148:(1): 1â25. Archived from
4942:10.2466/pms.2001.93.2.455
4891:10.2466/pms.1994.79.1.671
4670:10.3109/08820539909061464
4658:Seminars in Ophthalmology
4217:Journal of Human Genetics
3671:10.1007/s00439-007-0460-x
3395:10.1007/s00439-009-0683-0
2610:Am J Phys Anthropol. 2009
2545:Archives of Ophthalmology
2274:10.1186/s13293-016-0070-1
2135:10.1016/j.cub.2009.01.027
2063:10.1080/03014460210157394
2018:10.1016/j.tig.2004.06.010
1869:Journal of Human Genetics
1090:Red-appearing albino eyes
818:Journal of Human Genetics
131:variations in eye color.
4840:10.2466/pms.1992.75.1.91
4764:10.1177/0146167217733072
4080:NOAH â What is Albinism?
3708:. London. Archived from
2881:C. (25 September 2014).
2834:10.1109/MCG.2003.1242384
2822:IEEE Comput. Graph. Appl
2701:1 September 2010 at the
2337:Experimental Dermatology
2112:Janssens, A. Cecile J.W.
1192:Coloration of the sclera
867:, reduced expression of
813:University of Copenhagen
602:
543:
484:
385:
202:Experimental Dermatology
108:. This is an example of
5168:20 October 2006 at the
5083:10.3406/bmsap.1968.1417
4700:Evolutionary Psychology
4472:10.1136/pgmj.75.884.375
3926:10.3325/cmj.2013.54.381
3433:17 October 2008 at the
3121:Trans Am Ophthalmol Soc
2721:23 October 2010 at the
1482:Classification of color
1432:prostaglandin analogues
1106:can sometimes cause a "
991:
789:Blue eyes are a highly
743:A light blue iris with
727:
684:have green eyes. Among
587:, most commonly in the
461:, and parts of Central
94:iris pigment epithelium
4984:Ophthalmic Physiol Opt
4266:New Journal of Science
3521:6 October 2016 at the
3257:10.1006/exer.1996.0035
1659:10.1006/exer.1998.0518
1546:color is yellow-green.
1453:
1344:
1336:
1186:KayserâFleischer rings
1166:
1091:
1071:
1001:
755:
747:
724:
712:
561:
553:
494:
481:
414:
402:
44:
4751:Pers Soc Psychol Bull
4272:. hindawi.com: 1â28.
3743:(2). Wiley: 252â271.
3350:Beddoe, John (1971).
1742:10.1109/ICCV.2005.215
1504:physical anthropology
1494:, developed from the
1463:facial attractiveness
1451:
1342:
1334:
1160:KayserâFleischer ring
1157:
1089:
1066:
999:
753:
742:
718:
710:
559:
551:
492:
479:
412:
400:
165:Genetic determination
42:
5190:The Tech Interactive
4614:(Suppl 2): S117â23.
4543:. pp. 230â248.
4510:. pp. 277â297.
4456:"A homesick student"
4378:Ophthalmic Epidemiol
4230:10.1038/jhg.2010.126
4106:New Zealand PC World
3972:on 27 September 2011
3553:10.1136/bjo.71.7.549
2035:on 9 September 2006.
1882:10.1038/jhg.2010.126
1492:MartinâSchultz scale
1387:Waardenburg syndrome
1355:heterochromia iridis
1350:heterochromia iridum
1297:improve this article
1269:Heterochromia iridum
1122:Medical implications
1076:heterochromia iridum
1069:heterochromia iridum
1059:Two different colors
1043:. The Greek goddess
955:The first blue-eyed
356:Changes in eye color
302:Effect on eye color
154:, close to proximal
5152:on 2 February 2009.
4885:(1 Pt 2): 671â674.
4279:10.1155/2014/498276
4260:Solano, F. (2014).
4113:on 24 February 2010
4085:14 May 2012 at the
3897:on 22 October 2014.
3706:The Daily Telegraph
3339:. 26 February 2023.
1799:10.1021/j150239a007
1551:perception of color
802:mendelian recessive
772:Rayleigh scattering
762:. The iris pigment
723:with sea-green eyes
628:clarify the content
566:Rayleigh scattering
275:regulatory sequence
102:Rayleigh scattering
4795:The New York Times
3857:The New York Times
3749:10.1002/ajpa.24564
3712:on 1 November 2009
3480:10.1038/ng.2007.13
3214:10.1007/BF01203345
2784:10.1007/BF00233588
2597:, p. 661-662.
2462:10.1038/ng.2007.13
1498:, is one standard
1454:
1345:
1337:
1167:
1162:in a patient with
1092:
1072:
1002:
791:sexually dimorphic
756:
748:
725:
721:Chinchilla Persian
713:
686:European Americans
562:
554:
495:
482:
415:
403:
98:Tyndall scattering
79:stroma of the iris
45:
4558:978-0-511-54574-0
4525:978-1-4419-6501-1
4190:978-0-12-373553-9
3960:Lucy Southworth.
3807:978-0-691-08750-4
3636:. 31 January 2008
3584:Duffy et al. 2007
3474:(12): 1443â1452.
3038:Am. J. Ophthalmol
2945:Medland, Sarah E.
2667:978-0-520-03699-4
2625:Debrowski, Adam.
2395:Am. J. Hum. Genet
2350:10.1111/exd.14142
2232:978-1-000-06454-4
1951:Am. J. Hum. Genet
1751:978-0-7695-2334-7
1699:978-0-520-03699-4
1383:Horner's syndrome
1329:
1328:
1321:
1244:Transillumination
1176:, which prevents
1104:flash photography
925:with distinctive
878:release from the
645:
644:
350:
349:
159:regulatory region
152:gene polymorphism
16:(Redirected from
5232:
5173:
5163:Color Perception
5160:
5154:
5153:
5133:
5127:
5126:
5124:
5122:
5093:
5087:
5086:
5062:
5056:
5053:
5047:
5046:
5044:
5042:
5037:on 2 August 2016
5033:. Archived from
5027:
5021:
5014:
5008:
5007:
4979:
4970:
4969:
4925:
4919:
4918:
4874:
4868:
4867:
4823:
4814:
4813:
4811:
4809:
4786:
4777:
4776:
4766:
4742:
4736:
4735:
4725:
4715:
4697:
4688:
4682:
4681:
4653:
4647:
4638:
4632:
4631:
4603:
4597:
4586:
4580:
4569:
4563:
4562:
4536:
4530:
4529:
4503:
4494:
4493:
4483:
4451:
4445:
4444:
4416:
4410:
4409:
4373:
4367:
4366:
4338:
4332:
4331:
4291:
4285:
4283:
4281:
4257:
4251:
4250:
4232:
4208:
4202:
4201:
4199:
4197:
4160:
4154:
4153:
4151:
4149:
4144:on 27 March 2011
4140:. Archived from
4129:
4123:
4122:
4120:
4118:
4109:. Archived from
4096:
4090:
4077:
4071:
4070:
4068:
4066:
4061:. 6 October 2020
4051:
4042:
4041:
4039:
4037:
4031:All About Vision
4023:
4017:
4006:
4000:
3992:
3988:
3982:
3981:
3979:
3977:
3957:
3948:
3947:
3937:
3905:
3899:
3898:
3893:. Archived from
3891:The Boston Globe
3882:
3876:
3875:
3873:
3871:
3848:
3842:
3836:
3830:
3829:
3828:on 26 July 2011.
3824:. Archived from
3818:
3812:
3811:
3799:
3789:
3783:
3782:
3768:
3728:
3722:
3721:
3719:
3717:
3697:
3691:
3690:
3653:
3647:
3645:
3643:
3641:
3626:
3620:
3619:
3617:
3615:
3606:. Archived from
3595:
3586:
3581:
3575:
3574:
3564:
3532:
3526:
3513:
3507:
3506:
3504:
3502:
3459:
3450:
3444:
3438:
3425:
3419:
3418:
3377:
3371:
3370:
3347:
3341:
3340:
3333:
3327:
3326:
3278:
3269:
3268:
3240:
3234:
3233:
3197:
3191:
3190:
3180:
3165:Arch. Ophthalmol
3156:
3147:
3146:
3136:
3112:
3103:
3102:
3092:
3077:Arch. Ophthalmol
3068:
3062:
3061:
3029:
3020:
3019:
3009:
2985:
2979:
2978:
2968:
2940:
2931:
2930:
2920:
2902:
2877:
2871:
2870:
2868:
2866:
2860:All About Vision
2852:
2846:
2845:
2813:
2804:
2803:
2767:
2761:
2760:
2737:Pigment Cell Res
2732:
2726:
2712:
2706:
2693:
2687:
2678:
2672:
2671:
2651:
2642:
2641:
2639:
2637:
2631:All About Vision
2622:
2611:
2604:
2598:
2592:
2586:
2580:
2569:
2568:
2540:
2534:
2533:
2523:
2513:
2488:
2482:
2481:
2444:
2429:
2428:
2418:
2386:
2380:
2378:
2352:
2328:
2319:
2318:
2304:
2286:
2276:
2251:
2245:
2243:
2241:
2239:
2216:
2210:
2208:
2190:
2161:
2148:
2147:
2137:
2128:(5): R192âR193.
2107:
2101:
2089:
2083:
2082:
2046:
2037:
2036:
2034:
2028:. Archived from
2003:
1994:
1985:
1984:
1974:
1942:
1933:
1932:
1930:
1928:
1913:
1907:
1901:
1895:
1894:
1884:
1860:
1851:
1844:
1838:
1837:
1814:Pigment Cell Res
1809:
1803:
1802:
1782:
1773:
1770:
1764:
1763:
1735:
1715:
1704:
1703:
1683:
1672:
1671:
1661:
1637:
1631:
1630:
1599:Pigment Cell Res
1594:
1568:Human skin color
1520:structural color
1469:Impact on vision
1324:
1317:
1313:
1310:
1304:
1281:
1273:
1259:in photographs.
1253:pupillary reflex
1170:Wilson's disease
1164:Wilson's disease
1150:Wilson's disease
1115:Elizabeth Taylor
981:white population
968:
952:
938:
918:
784:structural color
640:
637:
631:
615:
614:
607:
510:great horned owl
360:A 1997 study of
312:Associated with
296:
295:
246:common in human
244:hypopigmentation
110:structural color
73:of light by the
55:phenotypic trait
21:
5240:
5239:
5235:
5234:
5233:
5231:
5230:
5229:
5220:Facial features
5200:
5199:
5182:
5177:
5176:
5170:Wayback Machine
5161:
5157:
5134:
5130:
5120:
5118:
5094:
5090:
5063:
5059:
5054:
5050:
5040:
5038:
5029:
5028:
5024:
5015:
5011:
4980:
4973:
4926:
4922:
4875:
4871:
4824:
4817:
4807:
4805:
4787:
4780:
4743:
4739:
4695:
4689:
4685:
4654:
4650:
4639:
4635:
4608:Surv Ophthalmol
4604:
4600:
4587:
4583:
4570:
4566:
4559:
4537:
4533:
4526:
4504:
4497:
4452:
4448:
4417:
4413:
4374:
4370:
4339:
4335:
4296:Guymer, Robyn H
4292:
4288:
4258:
4254:
4209:
4205:
4195:
4193:
4191:
4161:
4157:
4147:
4145:
4130:
4126:
4116:
4114:
4097:
4093:
4087:Wayback Machine
4078:
4074:
4064:
4062:
4053:
4052:
4045:
4035:
4033:
4025:
4024:
4020:
4007:
4003:
3990:
3989:
3985:
3975:
3973:
3958:
3951:
3906:
3902:
3883:
3879:
3869:
3867:
3849:
3845:
3839:Blue eyed Koala
3837:
3833:
3820:
3819:
3815:
3808:
3790:
3786:
3729:
3725:
3715:
3713:
3698:
3694:
3654:
3650:
3639:
3637:
3634:The Independent
3628:
3627:
3623:
3613:
3611:
3596:
3589:
3582:
3578:
3541:Br J Ophthalmol
3533:
3529:
3523:Wayback Machine
3514:
3510:
3500:
3498:
3468:Nature Genetics
3460:
3453:
3445:
3441:
3435:Wayback Machine
3426:
3422:
3378:
3374:
3364:
3348:
3344:
3335:
3334:
3330:
3279:
3272:
3241:
3237:
3198:
3194:
3157:
3150:
3113:
3106:
3069:
3065:
3030:
3023:
2986:
2982:
2941:
2934:
2893:(9): e1004572.
2878:
2874:
2864:
2862:
2854:
2853:
2849:
2814:
2807:
2772:Cell Tissue Res
2768:
2764:
2733:
2729:
2723:Wayback Machine
2714:Larry Bickford
2713:
2709:
2703:Wayback Machine
2694:
2690:
2679:
2675:
2668:
2652:
2645:
2635:
2633:
2623:
2614:
2605:
2601:
2593:
2589:
2581:
2572:
2541:
2537:
2504:(5): e1000934.
2489:
2485:
2456:(12): 1443â52.
2445:
2432:
2387:
2383:
2329:
2322:
2252:
2248:
2237:
2235:
2233:
2217:
2213:
2162:
2151:
2121:Current Biology
2108:
2104:
2090:
2086:
2047:
2040:
2032:
2001:
1995:
1988:
1943:
1936:
1926:
1924:
1915:
1914:
1910:
1902:
1898:
1861:
1854:
1845:
1841:
1810:
1806:
1783:
1776:
1771:
1767:
1752:
1716:
1707:
1700:
1684:
1675:
1638:
1634:
1595:
1591:
1586:
1559:
1539:Corucia zebrata
1512:Bruno K Schultz
1484:
1471:
1446:
1440:
1365:or acquired by
1347:Heterochromia (
1325:
1314:
1308:
1305:
1294:
1282:
1271:
1265:
1248:eye examination
1235:
1224:
1218:
1194:
1182:Golgi apparatus
1152:
1124:
1084:
1074:As a result of
1061:
1056:
1025:AurĂšs Mountains
994:
975:
972:Sclater's lemur
969:
960:
953:
944:
939:
930:
919:
891:southern Europe
806:polygenic trait
737:
730:
641:
635:
632:
625:
616:
612:
605:
546:
516:within certain
487:
395:
388:
383:
381:Eye color range
362:White Americans
358:
167:
148:recessive trait
106:vitreous humour
35:
28:
23:
22:
15:
12:
11:
5:
5238:
5228:
5227:
5222:
5217:
5212:
5198:
5197:
5192:
5181:
5180:External links
5178:
5175:
5174:
5155:
5128:
5088:
5077:(3): 183â218.
5057:
5048:
5022:
5009:
4971:
4936:(2): 455â460.
4920:
4869:
4815:
4778:
4737:
4706:(2): 137â146.
4683:
4648:
4633:
4598:
4581:
4564:
4557:
4531:
4524:
4495:
4466:(884): 375â8.
4460:Postgrad Med J
4446:
4427:(2): 237â238.
4411:
4384:(5): 293â302.
4368:
4333:
4286:
4252:
4203:
4189:
4155:
4124:
4091:
4072:
4043:
4018:
4001:
3983:
3949:
3900:
3877:
3843:
3831:
3813:
3806:
3784:
3723:
3692:
3648:
3621:
3610:on 1 July 2013
3587:
3576:
3527:
3508:
3451:
3439:
3420:
3389:(3): 395â410.
3383:Human Genetics
3372:
3362:
3342:
3328:
3293:(4): 686â689.
3270:
3235:
3202:Doc Ophthalmol
3192:
3148:
3104:
3063:
3021:
2980:
2959:(2): 197â210.
2932:
2872:
2847:
2805:
2762:
2727:
2707:
2688:
2673:
2666:
2643:
2612:
2599:
2587:
2585:, p. 660.
2570:
2535:
2483:
2430:
2381:
2343:(9): 864â875.
2320:
2246:
2231:
2211:
2149:
2102:
2100:14 March 2009.
2084:
2051:Ann. Hum. Biol
2038:
1986:
1963:10.1086/510885
1934:
1923:on 5 June 2011
1908:
1896:
1852:
1839:
1804:
1793:(5): 498â501.
1774:
1765:
1750:
1720:Sing Bing Kang
1705:
1698:
1673:
1632:
1588:
1587:
1585:
1582:
1581:
1580:
1575:
1570:
1565:
1558:
1555:
1483:
1480:
1470:
1467:
1459:corneal limbus
1442:Main article:
1439:
1436:
1424:X-inactivation
1327:
1326:
1285:
1283:
1276:
1267:Main article:
1264:
1261:
1257:red eye effect
1234:
1231:
1220:Main article:
1217:
1214:
1193:
1190:
1151:
1148:
1140:uveal melanoma
1123:
1120:
1108:red-eye effect
1083:
1082:Red and violet
1080:
1060:
1057:
1055:
1052:
1011:Mie scattering
993:
990:
977:
976:
970:
963:
961:
954:
947:
945:
940:
933:
931:
920:
913:
847:Human Genetics
729:
726:
674:Central Europe
643:
642:
619:
617:
610:
604:
601:
593:United Kingdom
545:
542:
518:chromatophores
486:
483:
427:Southeast Asia
387:
384:
382:
379:
357:
354:
348:
347:
344:
338:
337:
334:
328:
327:
324:
318:
317:
310:
304:
303:
300:
166:
163:
77:medium in the
26:
9:
6:
4:
3:
2:
5237:
5226:
5223:
5221:
5218:
5216:
5213:
5211:
5208:
5207:
5205:
5196:
5193:
5191:
5187:
5184:
5183:
5171:
5167:
5164:
5159:
5151:
5147:
5143:
5139:
5132:
5117:
5113:
5110:(8): 1592â8.
5109:
5105:
5104:
5099:
5092:
5084:
5080:
5076:
5072:
5068:
5061:
5052:
5036:
5032:
5026:
5019:
5013:
5005:
5001:
4997:
4993:
4990:(2): 103â10.
4989:
4985:
4978:
4976:
4967:
4963:
4959:
4955:
4951:
4947:
4943:
4939:
4935:
4931:
4924:
4916:
4912:
4908:
4904:
4900:
4896:
4892:
4888:
4884:
4880:
4873:
4865:
4861:
4857:
4853:
4849:
4845:
4841:
4837:
4833:
4829:
4822:
4820:
4804:
4800:
4796:
4792:
4785:
4783:
4774:
4770:
4765:
4760:
4756:
4752:
4748:
4741:
4733:
4729:
4724:
4719:
4714:
4709:
4705:
4701:
4694:
4687:
4679:
4675:
4671:
4667:
4664:(3): 114â23.
4663:
4659:
4652:
4646:
4642:
4637:
4629:
4625:
4621:
4617:
4613:
4609:
4602:
4596:
4592:
4591:
4585:
4579:
4575:
4574:
4568:
4560:
4554:
4550:
4546:
4542:
4535:
4527:
4521:
4517:
4513:
4509:
4502:
4500:
4491:
4487:
4482:
4477:
4473:
4469:
4465:
4461:
4457:
4450:
4442:
4438:
4434:
4430:
4426:
4422:
4415:
4407:
4403:
4399:
4395:
4391:
4387:
4383:
4379:
4372:
4364:
4360:
4356:
4352:
4349:(2): 247â52.
4348:
4344:
4337:
4329:
4325:
4321:
4317:
4313:
4309:
4305:
4301:
4297:
4290:
4280:
4275:
4271:
4267:
4263:
4256:
4248:
4244:
4240:
4236:
4231:
4226:
4222:
4218:
4214:
4207:
4192:
4186:
4182:
4178:
4174:
4170:
4166:
4159:
4143:
4139:
4135:
4128:
4112:
4108:
4107:
4102:
4095:
4088:
4084:
4081:
4076:
4060:
4056:
4050:
4048:
4032:
4028:
4022:
4016:
4012:
4011:
4005:
3999:
3995:
3987:
3971:
3967:
3963:
3956:
3954:
3945:
3941:
3936:
3931:
3927:
3923:
3919:
3915:
3914:Croat. Med. J
3911:
3904:
3896:
3892:
3888:
3881:
3866:
3862:
3858:
3854:
3847:
3840:
3835:
3827:
3823:
3817:
3809:
3803:
3798:
3797:
3788:
3781:
3776:
3772:
3767:
3762:
3758:
3754:
3750:
3746:
3742:
3738:
3734:
3727:
3711:
3707:
3703:
3696:
3688:
3684:
3680:
3676:
3672:
3668:
3665:(2): 177â87.
3664:
3660:
3652:
3635:
3631:
3625:
3609:
3605:
3601:
3594:
3592:
3585:
3580:
3572:
3568:
3563:
3558:
3554:
3550:
3547:(7): 549â52.
3546:
3542:
3538:
3531:
3524:
3520:
3517:
3512:
3497:
3493:
3489:
3485:
3481:
3477:
3473:
3469:
3465:
3458:
3456:
3448:
3443:
3436:
3432:
3429:
3424:
3417:
3412:
3408:
3404:
3400:
3396:
3392:
3388:
3384:
3376:
3369:
3365:
3363:9780091013707
3359:
3355:
3354:
3346:
3338:
3332:
3324:
3320:
3316:
3312:
3308:
3304:
3300:
3296:
3292:
3288:
3284:
3277:
3275:
3266:
3262:
3258:
3254:
3250:
3246:
3239:
3231:
3227:
3223:
3219:
3215:
3211:
3208:(4): 367â76.
3207:
3203:
3196:
3188:
3184:
3179:
3174:
3170:
3166:
3162:
3155:
3153:
3144:
3140:
3135:
3130:
3126:
3122:
3118:
3111:
3109:
3100:
3096:
3091:
3086:
3083:(6): 853â60.
3082:
3078:
3074:
3067:
3059:
3055:
3051:
3047:
3043:
3039:
3035:
3028:
3026:
3017:
3013:
3008:
3003:
2999:
2995:
2991:
2984:
2976:
2972:
2967:
2962:
2958:
2954:
2950:
2946:
2939:
2937:
2928:
2924:
2919:
2914:
2910:
2906:
2901:
2896:
2892:
2888:
2887:PLOS Genetics
2884:
2876:
2861:
2857:
2851:
2843:
2839:
2835:
2831:
2827:
2823:
2819:
2812:
2810:
2801:
2797:
2793:
2789:
2785:
2781:
2778:(2): 387â95.
2777:
2773:
2766:
2758:
2754:
2750:
2746:
2742:
2738:
2731:
2724:
2720:
2717:
2711:
2704:
2700:
2697:
2692:
2686:
2682:
2677:
2669:
2663:
2659:
2658:
2650:
2648:
2632:
2628:
2621:
2619:
2617:
2609:
2603:
2596:
2591:
2584:
2579:
2577:
2575:
2566:
2562:
2558:
2554:
2551:(5): 659â63.
2550:
2546:
2539:
2531:
2527:
2522:
2517:
2512:
2507:
2503:
2499:
2498:PLOS Genetics
2495:
2487:
2479:
2475:
2471:
2467:
2463:
2459:
2455:
2451:
2443:
2441:
2439:
2437:
2435:
2426:
2422:
2417:
2412:
2408:
2404:
2401:(2): 411â23.
2400:
2396:
2392:
2385:
2376:
2372:
2368:
2364:
2360:
2356:
2351:
2346:
2342:
2338:
2334:
2327:
2325:
2317:
2312:
2308:
2303:
2298:
2294:
2290:
2285:
2280:
2275:
2270:
2266:
2262:
2258:
2250:
2234:
2228:
2224:
2223:
2215:
2206:
2202:
2198:
2194:
2189:
2184:
2180:
2176:
2172:
2168:
2160:
2158:
2156:
2154:
2145:
2141:
2136:
2131:
2127:
2123:
2122:
2117:
2113:
2106:
2099:
2098:
2097:New Scientist
2093:
2088:
2080:
2076:
2072:
2068:
2064:
2060:
2057:(6): 657â66.
2056:
2052:
2045:
2043:
2031:
2027:
2023:
2019:
2015:
2012:(8): 327â32.
2011:
2007:
2000:
1993:
1991:
1982:
1978:
1973:
1968:
1964:
1960:
1957:(2): 241â52.
1956:
1952:
1948:
1941:
1939:
1922:
1918:
1912:
1905:
1900:
1892:
1888:
1883:
1878:
1874:
1870:
1866:
1859:
1857:
1849:
1843:
1835:
1831:
1827:
1823:
1820:(2): 129â31.
1819:
1815:
1808:
1800:
1796:
1792:
1788:
1781:
1779:
1769:
1761:
1757:
1753:
1747:
1743:
1739:
1734:
1733:10.1.1.87.418
1729:
1725:
1721:
1714:
1712:
1710:
1701:
1695:
1691:
1690:
1682:
1680:
1678:
1669:
1665:
1660:
1655:
1651:
1647:
1643:
1636:
1628:
1624:
1620:
1616:
1612:
1608:
1605:(6): 454â64.
1604:
1600:
1593:
1589:
1579:
1576:
1574:
1571:
1569:
1566:
1564:
1561:
1560:
1554:
1552:
1547:
1545:
1541:
1540:
1535:
1532:
1527:
1525:
1521:
1515:
1513:
1509:
1508:Rudolf Martin
1505:
1501:
1497:
1493:
1488:
1479:
1477:
1476:visual acuity
1466:
1464:
1460:
1450:
1445:
1435:
1433:
1429:
1425:
1420:
1418:
1413:
1411:
1406:
1405:Lee Van Cleef
1401:
1399:
1395:
1390:
1388:
1384:
1380:
1376:
1372:
1368:
1364:
1360:
1356:
1352:
1351:
1341:
1333:
1323:
1320:
1312:
1309:November 2012
1302:
1298:
1292:
1291:
1286:This section
1284:
1280:
1275:
1274:
1270:
1263:Heterochromia
1260:
1258:
1254:
1249:
1245:
1241:
1230:
1228:
1223:
1213:
1211:
1207:
1203:
1199:
1189:
1187:
1183:
1179:
1175:
1171:
1165:
1161:
1156:
1147:
1145:
1141:
1137:
1133:
1128:
1119:
1116:
1111:
1109:
1105:
1101:
1097:
1088:
1079:
1077:
1070:
1065:
1054:Special cases
1051:
1048:
1046:
1042:
1038:
1034:
1030:
1026:
1022:
1021:Shawia people
1019:
1014:
1012:
1008:
998:
989:
987:
982:
973:
967:
962:
958:
951:
946:
943:
937:
932:
928:
924:
923:Birman kitten
917:
912:
911:
910:
908:
904:
900:
896:
892:
888:
883:
881:
877:
872:
870:
866:
862:
858:
857:
852:
848:
843:
841:
840:out of Africa
836:
832:
828:
824:
820:
819:
814:
809:
807:
803:
798:
796:
792:
787:
785:
781:
777:
773:
769:
765:
761:
760:vitreous body
752:
746:
741:
735:
722:
717:
709:
705:
703:
697:
695:
691:
687:
683:
679:
675:
671:
667:
662:
660:
656:
652:
651:
639:
629:
623:
620:This section
618:
609:
608:
600:
598:
594:
590:
586:
581:
579:
575:
570:
567:
558:
550:
541:
539:
538:South America
535:
531:
527:
523:
519:
515:
511:
507:
502:
500:
491:
478:
474:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
411:
407:
399:
393:
378:
376:
371:
368:
365:
363:
353:
345:
343:
340:
339:
335:
333:
330:
329:
325:
323:
320:
319:
315:
311:
309:
306:
305:
301:
298:
297:
294:
292:
288:
284:
280:
276:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
232:
230:
229:chromosome 15
226:
225:
220:
219:
213:
211:
210:out of Africa
207:
203:
199:
194:
192:
188:
182:
180:
176:
172:
162:
160:
157:
153:
149:
145:
144:
139:
138:
132:
130:
126:
122:
118:
113:
111:
107:
103:
99:
95:
91:
87:
82:
80:
76:
72:
68:
64:
60:
56:
53:
49:
41:
37:
33:
19:
5158:
5150:the original
5145:
5141:
5131:
5119:. Retrieved
5107:
5101:
5091:
5074:
5070:
5060:
5051:
5039:. Retrieved
5035:the original
5025:
5012:
4987:
4983:
4933:
4929:
4923:
4882:
4878:
4872:
4834:(1): 91â95.
4831:
4827:
4806:. Retrieved
4794:
4757:(1): 80â91.
4754:
4750:
4740:
4703:
4699:
4686:
4661:
4657:
4651:
4636:
4611:
4607:
4601:
4588:
4584:
4571:
4567:
4540:
4534:
4507:
4463:
4459:
4449:
4424:
4420:
4414:
4381:
4377:
4371:
4346:
4342:
4336:
4306:(6): 465â9.
4303:
4299:
4289:
4269:
4265:
4255:
4220:
4216:
4206:
4194:. Retrieved
4172:
4168:
4158:
4146:. Retrieved
4142:the original
4137:
4127:
4115:. Retrieved
4111:the original
4104:
4094:
4075:
4063:. Retrieved
4058:
4034:. Retrieved
4030:
4021:
4008:
4004:
3997:
3986:
3974:. Retrieved
3970:the original
3965:
3920:(4): 381â6.
3917:
3913:
3903:
3895:the original
3890:
3880:
3868:. Retrieved
3856:
3846:
3834:
3826:the original
3816:
3795:
3787:
3778:
3740:
3736:
3726:
3714:. Retrieved
3710:the original
3705:
3695:
3662:
3658:
3651:
3638:. Retrieved
3633:
3624:
3612:. Retrieved
3608:the original
3579:
3544:
3540:
3530:
3511:
3499:. Retrieved
3471:
3467:
3442:
3423:
3414:
3386:
3382:
3375:
3367:
3352:
3345:
3331:
3290:
3286:
3251:(3): 293â7.
3248:
3245:Exp. Eye Res
3244:
3238:
3205:
3201:
3195:
3171:(6): 811â4.
3168:
3164:
3124:
3120:
3080:
3076:
3066:
3044:(3): 384â6.
3041:
3037:
2997:
2993:
2983:
2956:
2952:
2890:
2886:
2875:
2863:. Retrieved
2859:
2856:"Amber eyes"
2850:
2825:
2821:
2775:
2771:
2765:
2743:(3): 202â8.
2740:
2736:
2730:
2710:
2691:
2676:
2656:
2634:. Retrieved
2630:
2602:
2590:
2548:
2544:
2538:
2501:
2497:
2486:
2453:
2449:
2398:
2394:
2384:
2340:
2336:
2314:
2264:
2260:
2249:
2236:. Retrieved
2221:
2214:
2170:
2166:
2125:
2119:
2105:
2095:
2087:
2054:
2050:
2030:the original
2009:
2006:Trends Genet
2005:
1954:
1950:
1925:. Retrieved
1921:the original
1911:
1899:
1872:
1868:
1846:Morris, PJ.
1842:
1817:
1813:
1807:
1790:
1786:
1768:
1723:
1688:
1652:(3): 293â9.
1649:
1646:Exp. Eye Res
1645:
1635:
1602:
1598:
1592:
1548:
1537:
1528:
1516:
1496:Martin scale
1489:
1485:
1472:
1455:
1421:
1416:
1414:
1402:
1391:
1354:
1348:
1346:
1315:
1306:
1295:Please help
1290:verification
1287:
1236:
1225:
1195:
1168:
1129:
1125:
1112:
1093:
1073:
1049:
1037:Central Asia
1015:
1003:
978:
903:North Africa
895:Central Asia
884:
880:pineal gland
873:
868:
860:
854:
846:
844:
816:
810:
799:
788:
757:
698:
663:
648:
646:
633:
626:Please help
621:
582:
573:
571:
563:
534:North Africa
514:xanthopterin
503:
496:
457:, among the
431:Central Asia
416:
404:
401:A brown iris
372:
369:
366:
359:
351:
282:
278:
271:
251:
235:
233:
222:
216:
214:
201:
195:
183:
168:
141:
135:
133:
114:
83:
59:pigmentation
47:
46:
36:
32:Iris (color)
4027:"Gray eyes"
3991:(in French)
3640:21 December
3501:21 February
3000:: 217â222.
2828:(6): 70â5.
2284:10810/32358
2188:10234/86709
1578:Xanthophore
1524:limbal ring
1500:color scale
1444:Limbal ring
1438:Limbal ring
1428:calico cats
1410:David Bowie
1029:Middle East
942:Jungle crow
835:ancient DNA
745:limbal ring
682:Netherlands
657:during the
636:August 2023
589:Netherlands
530:Middle East
198:ancient DNA
125:carotenoids
5204:Categories
5142:Polyphemos
5121:19 October
5041:13 January
4508:The Sclera
4223:(1): 5â7.
4196:11 October
4165:"Albinism"
4059:WorldAtlas
3976:19 October
3870:2 February
3716:19 October
3659:Hum. Genet
3614:19 October
2636:4 February
2450:Nat. Genet
1927:19 October
1875:(1): 5â7.
1584:References
1563:Hair color
1041:South Asia
899:South Asia
887:Baltic Sea
825:region in
764:epithelium
711:Green eyes
702:lipochrome
659:Bronze Age
522:lipofuscin
506:pteridines
499:lipochrome
471:South Asia
435:South Asia
299:Gene name
129:phenotypic
117:pteridines
71:scattering
18:Brown eyes
5210:Eye color
4950:0031-5125
4899:0031-5125
4848:0031-5125
4803:0362-4331
4595:eMedicine
4578:eMedicine
4117:9 January
3865:0362-4331
3757:2692-7691
3307:1120-6721
2909:1553-7390
2716:Eye Color
2595:Bito 1997
2583:Bito 1997
2375:220335539
2359:0906-6705
2293:2042-6410
2267:(1): 17.
2197:1872-4973
1728:CiteSeerX
1619:0893-5785
1573:Iridology
1534:recessive
1531:autosomal
1379:chimerism
1363:inherited
1210:hepatitis
1206:cirrhosis
1174:ATPase 7B
1144:cataracts
1033:West Asia
929:blue eyes
907:West Asia
876:melatonin
831:Neolithic
823:Black Sea
754:Blue iris
597:Low Saxon
560:Hazel eye
552:Hazel eye
493:Amber eye
467:West Asia
439:West Asia
423:East Asia
268:skin tone
256:freckling
234:The gene
206:Near East
179:Rotterdam
52:polygenic
48:Eye color
5166:Archived
4966:22785194
4958:11769902
4864:31398375
4773:28978250
4732:22947961
4723:10519137
4678:10790575
4573:Aniridia
4490:10435182
4441:11004303
4398:14566630
4363:15226032
4343:Prev Med
4328:25878963
4320:14641151
4247:33808164
4239:20944644
4169:Albinism
4148:26 March
4083:Archived
3944:23986280
3775:36790744
3766:10083917
3679:18172690
3604:NBC News
3519:Archived
3496:19313549
3488:17952075
3431:Archived
3411:21347353
3403:19449030
3323:40940828
3315:19551689
3230:30893783
3187:10369595
3143:11190014
3099:11405836
3058:12614760
3016:14971580
2975:15169604
2953:Twin Res
2927:25254375
2719:Archived
2699:Archived
2683:(OMIM):
2530:20463881
2478:19313549
2470:17952075
2425:18252221
2367:32621306
2311:26998216
2205:23601698
2144:19278628
2079:25364754
2071:12573082
2026:15262401
1981:17236130
1891:20944644
1627:16280011
1557:See also
1544:dominant
1502:used in
1417:in utero
1240:albinism
1227:Aniridia
1222:Aniridia
1216:Aniridia
1202:jaundice
1096:albinism
1018:Algerian
1007:collagen
1000:Gray eye
986:Slovenes
927:sapphire
865:promoter
694:Germanic
666:Northern
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