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Antiemetic

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2680: 2701: 32: 1128:"Schedules of Controlled Substances: Rescheduling of the Food and Drug Administration Approved Product Containing Synthetic Dronabinol [(-)-greek-DSUP9/SUP -(trans)-Tetrahydrocannabinol] in Sesame Oil and Encapsulated in Soft Gelatin Capsules From Schedule II to Schedule III" 1389:
Abdel-Aziz H, Windeck T, Ploch M, Verspohl EJ (2006-01-13), "Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum",
1603:"Sub-hypnotic dose of propofol as antiemetic prophylaxis attenuates intrathecal morphine-induced postoperative nausea and vomiting, and pruritus in parturient undergoing cesarean section — a randomized control trial" 420:
nausea. H1 receptors in central areas include area postrema and vomiting center in the vestibular nucleus. Also, many of the antihistamines listed here also block muscarinic acetylcholine receptors.
1127: 622:) is given in low dose at the onset of a general anesthetic as an effective antiemetic. It is also used in chemotherapy as a single drug as well as with other antiemetics such as 5-HT 1468: 487:(Pentazine, Phenergan, Promacot) can be administered via a rectal suppository, intravenous injection, oral tablet or oral suspension for adults and children over 2 years of age. 1023:
Vincent, Beverly J.; McQuiston, Debra J.; Einhorn, Lawrence H.; Nagy, Catherine M.; Brames, Mary J. (1983-05-01). "Review of Cannabinoids and their Antiemetic Effectiveness".
1099:"2017 - Final Rule: Placement of FDA-Approved Products of Oral Solutions Containing Dronabinol [(-)-delta-9-trans-tetrahydrocannabinol (delta-9-THC)] in Schedule II" 1201:"International differences in patterns of cannabis use among youth: Prevalence, perceptions of harm, and driving under the influence in Canada, England & United States" 2632: 1712: 505:, cytotoxic nausea, and vomiting, or who are unresponsive to other agents. These may cause changes in perception, dizziness, and loss of coordination. 1680: 1257: 962:
Kast RE, Foley KF (July 2007). "Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects".
254:) can be administered in tablet (Kytril), oral solution (Kytril), injection (Kytril), or in a single transdermal patch to the upper arm (SANCUSO). 2689: 1098: 555:
is an oral spray containing THC and CBD. It is currently legal in Canada and a few countries in Europe and the US as of June 25, 2018
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National Institute of Mental Health. PDSD Ki Database (Internet) . Chapel Hill (NC): University of North Carolina. 1998-2013. Available from:
1507: 1702: 2483: 2443: 512: 264:) is administered in an oral tablet form, orally dissolving tablet form, orally dissolving film, sublingual, or in an IV/IM injection. 1281:
Honarmand, Azim; Safavi, Mohammadreza; Chegeni, Mansoureh; Hirmanpour, Anahita; Nazem, Masoud; Sarizdi, Seyyad Hamid (January 2016).
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Kampo, Sylvanus; Afful, Alfred Parker; Mohammed, Shiraj; Ntim, Michael; Buunaaim, Alexis D. B.; Anabah, Thomas Winsum (2019-09-14).
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Huang, Q.; Iwamoto, Y.; Aoki, S.; Tanaka, N.; Tajima, K.; Yamahara, J.; Takaishi, Y.; Yoshida, M.; Tomimatsu, T.; Tamai, Y. (1991).
1342:"Antiemetic activity of corticosteroids in patients receiving cancer chemotherapy: dosing, efficacy, and tolerability analysis" 2738: 2056: 900: 662:. Preliminary clinical data suggests ginger may be effective for treatment of nausea and/or vomiting in a number of settings. 214:. As such, they can be used to treat post-operative and cytotoxic drug nausea & vomiting. However, they can also cause 2343: 2336: 96: 2086: 1949: 416:
antagonists) are effective in many conditions, including motion sickness, morning sickness in pregnancy, and to combat
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Some antiemetics previously thought to cause birth defects appear safe for use by pregnant women in the treatment of
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receptor antagonists and NK1 receptor antagonist, but the specific mechanism of action is not fully understood.
53: 1154:"THC and CBD oromucosal spray (Sativex ® ) in the management of spasticity associated with multiple sclerosis" 998: 579:(Ativan) is said to be very good as an adjunct treatment for nausea along with first line medications such as 674:
is given intravenously. It has been used in an acute care setting in hospital as a rescue therapy for emesis.
82: 1938: 1720: 1469:"Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review" 1283:"Prophylactic antiemetic effects of Midazolam, Ondansetron, and their combination after middle ear surgery" 916:
Pae C-U (2006). "Low-dose mirtazapine may be successful treatment option for severe nausea and vomiting".
2549: 49: 2199: 1688: 638: 569:(Versed) is given at the onset of anesthesia and has been shown in recent trials to be as effective as 64: 1106: 2731: 149: 893:
Drugs During Pregnancy and Lactation: Handbook of Prescription Drugs and Comparative Risk Assessment
3131: 2843: 2254: 1932: 1783: 372: 42: 802:"Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents" 2291: 2046: 1533:"Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials" 538: 296:, radiation sickness, opioids, cytotoxic drugs and general anaesthetics. Side effects include 211: 207: 183: 1976: 1912: 1757: 888: 597: 593: 334: 301: 3225: 3039: 2954: 2879: 2724: 2051: 2031: 1900: 8: 3086: 2969: 2660: 2396: 2182: 1961: 1788: 1467:
Marx, WM; Teleni L; McCarthy AL; Vitetta L; McKavanagh D; Thomson D; Isenring E. (2013).
743:"Use of antiemetics in children with acute gastroenteritis: Are they safe and effective?" 289: 160: 1581: 1153: 1152:
Sastre-Garriga, Jaume; Vila, Carlos; Clissold, Stephen; Montalban, Xavier (2011-05-11).
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is claimed to help nausea or stomach pain when added into a tea or peppermint candies.
3020: 2700: 2655: 2438: 2428: 2331: 2161: 2117: 2101: 1905: 1895: 1838: 1828: 1642: 1624: 1562: 1554: 1491: 1449: 1428:"Anti-5-hydroxytryptamine3 effect of galanolactone, diterpenoid isolated from ginger" 1409: 1371: 1363: 1322: 1304: 1238: 1220: 1181: 1173: 1048: 1040: 1036: 979: 975: 933: 896: 839: 821: 782: 764: 716: 634: 227: 1503: 1060: 945: 467:
that also has antiemetic effects. It is a potent histamine H1 receptor antagonist, K
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act on the brainstem and are used to treat nausea and vomiting associated with
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Schaefer, Christof; Scialli, Anthony; Rost van Tonningen, Margreet (2001).
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when in sesame oil and encapsulated in a soft gelatin capsule (Marinol).
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Fedorowicz, Zbys; Jagannath, Vanitha A; Carter, Ben (2011-09-07).
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Progress in Neuro-Psychopharmacology and Biological Psychiatry
859:"Nausea and Vomiting in Pregnancy - American Family Physician" 2603: 2313: 1808: 693: 511:, also known as medical marijuana in the United States, is a 274:) can be administered in oral capsules or in injection form. 2307: 1022: 284:) can be administered in an injection or in oral capsules. 799: 530:
drug in the U.S. when in an oral solution (Syndros), and
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is purported to be antiemetic. It is a popular spice in
240:) can be administered in tablet form or in an injection. 1600: 1425: 1713:
Anatomical Therapeutic Chemical Classification System
1258:"Medical cannabis and regulatory framework in Europe" 384:) is a commercially available NK1 receptor antagonist 857:
Quinlan, Jeffrey D.; Hill, D. Ashley (1 June 2003).
1582:"The Claim: Eating Ginger Can Cure Motion Sickness" 310:(Barhemsys), administered by intravenous injection. 56:. Unsourced material may be challenged and removed. 354:Compazine, Stemzine, Buccastem, Stemetil, Phenotil 961: 3217: 1198: 400:) another recently approved drug from this class 563:(GABA receptor positive allosteric modulators) 668:is also claimed to be an effective antiemetic. 2732: 1696: 390:is an investigational NK1 receptor antagonist 1711:Major chemical drug groups – based upon the 1579: 1530: 724:– substances that induce nausea and vomiting 880: 856: 806:The Cochrane Database of Systematic Reviews 175:, especially if the patient is dehydrated. 2739: 2725: 1703: 1689: 1524: 850: 740: 144:. Antiemetics are typically used to treat 1636: 1618: 1548: 1443: 1357: 1316: 1298: 1232: 833: 776: 758: 747:Journal of Emergencies, Trauma, and Shock 686:is purported to have antiemetic activity. 116:Learn how and when to remove this message 1531:Ernst, E.; Pittler, M. H. (March 2000). 1339: 1287:Journal of Research in Pharmacy Practice 889:"Antiemetics and hyperemesis gravidarum" 1199:Wadsworth, E; Hammond, D (2019-03-04). 915: 471:=1.6 nM, and also exhibits notable 5-HT 171:. They may be used for severe cases of 16:Drug used to prevent nausea or vomiting 3218: 2690:Pharmacological classification systems 2057:Selective estrogen receptor modulators 1460: 1432:Chemical & Pharmaceutical Bulletin 1255: 2746: 2720: 2337:Non-steroidal anti-inflammatory drugs 1684: 1580:O'Connor, Anahad (August 21, 2007). 957: 955: 362:(Use limited by sedating properties) 54:adding citations to reliable sources 25: 1950:Angiotensin II receptor antagonists 1653: 1340:Grunberg, S. M. (1 February 2007). 13: 1550:10.1093/oxfordjournals.bja.a013442 1158:Expert Review of Neurotherapeutics 14: 3237: 952: 2699: 2679: 2678: 1037:10.2165/00003495-198300251-00006 976:10.1111/j.1365-2354.2006.00760.x 895:. Gulf Professional Publishing. 30: 2087:Hypothalamic–pituitary hormones 1659: 1594: 1573: 1419: 1382: 1333: 1274: 1249: 1192: 1145: 1120: 1091: 964:European Journal of Cancer Care 41:needs additional citations for 1537:British Journal of Anaesthesia 1067: 1016: 990: 909: 818:10.1002/14651858.CD005506.pub5 793: 734: 1: 1839:Thrombolytics / fibrinolytics 728: 2550:Wakefulness-promoting agents 1662:"MUSCIMOL - CAMEO Chemicals" 1406:10.1016/j.ejphar.2005.10.049 1217:10.1016/j.addbeh.2018.10.050 7: 930:10.1016/j.pnpbp.2006.03.015 710: 10: 3242: 2200:Intravenous immunoglobulin 1262:Drug Discovery World (DDW) 1103:www.deadiversion.usdoj.gov 741:Manteuffel, Jacob (2009). 637:is thought to work on the 501:are used in patients with 333:(limited in usefulness by 136:that is effective against 18: 3172: 3130: 3082: 3029: 2968: 2923: 2878: 2759: 2674: 2630: 2602: 2558: 2367: 2302: 2265: 2213: 2126: 2070: 2030: 1987: 1871: 1807: 1719: 1620:10.1186/s12871-019-0847-y 1256:Rahman, Lu (2021-02-03). 863:American Family Physician 2880:5-HT serotonin G-protein 2255:Topoisomerase inhibitors 1939:renin–angiotensin system 1933:Calcium channel blockers 1300:10.4103/2279-042X.176556 189: 19:Not to be confused with 760:10.4103/0974-2700.44674 526:(Marinol/Syndros) is a 373:NK1 receptor antagonist 2047:Hormonal contraception 1977:Bile acid sequestrants 1758:Proton-pump inhibitors 1721:gastrointestinal tract 539:synthetic cannabinoids 212:gastrointestinal tract 208:central nervous system 184:hyperemesis gravidarum 1359:10.1093/annonc/mdl347 999:"PDSP Database - UNC" 182:and the more serious 2955:Tetrahydrocannabinol 2882:receptor antagonists 2656:Radiopharmaceuticals 2444:Antiparkinson agents 290:Dopamine antagonists 200:receptor antagonists 161:general anaesthetics 50:improve this article 2767:channel antagonists 2439:Antimigraine agents 2429:Antidementia agents 2332:Anti-inflammatories 2022:Medicated dressings 1962:Antihyperlipidemics 1789:Diabetes medication 1205:Addictive Behaviors 447:(Gravol, Dramamine) 2292:Immunosuppressants 2162:Antimycobacterials 2118:Antithyroid agents 2102:Mineralocorticoids 1906:Cardiac stimulants 1896:Cardiac glycosides 1888:cardiac therapy / 1784:Anti-obesity drugs 1607:BMC Anesthesiology 1587:The New York Times 1488:10.1111/nure.12016 1445:10.1248/cpb.39.397 1346:Annals of Oncology 481:(Bonine, Antivert) 453:(Bonjesta, Unisom) 414:histamine receptor 3213: 3212: 3021:Trimethobenzamide 2714: 2713: 2617:Ophthalmologicals 2327:Anabolic steroids 2230:Anticancer agents 2193:Ectoparasiticides 1913:Antihypertensives 1861:Antifibrinolytics 1170:10.1586/ern.11.47 1075:"Drug Scheduling" 902:978-0-444-50763-1 717:Cancer and nausea 635:Trimethobenzamide 545:(Cesamet) or the 272:Setrovel, Navoban 206:receptors in the 167:directed against 126: 125: 118: 100: 3233: 3092:anticholinergics 3016:Thiethylperazine 3011:Prochlorperazine 2741: 2734: 2727: 2718: 2717: 2703: 2682: 2681: 2666:Senotherapeutics 2520:Neuroprotectives 2515:Mood stabilizers 2414:Anti-ADHD agents 2354:Muscle relaxants 2287:Immunostimulants 2282:Immunomodulators 2114:Thyroid hormones 2052:Fertility agents 1955:Renin inhibitors 1846:Antihemorrhagics 1813:forming organs ( 1799:Dietary minerals 1705: 1698: 1691: 1682: 1681: 1676: 1675: 1673: 1672: 1657: 1651: 1650: 1640: 1622: 1598: 1592: 1591: 1577: 1571: 1570: 1552: 1528: 1522: 1521: 1519: 1518: 1512: 1506:. 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171–175. 1079:www.dea.gov 598:scopolamine 571:ondansetron 528:Schedule II 491:Hydroxyzine 475:antagonism. 457:Mirtazapine 424:Cinnarizine 331:Haloperidol 314:Domperidone 308:Amisulpride 268:Tropisetron 258:Ondansetron 244:Granisetron 21:antisemitic 3164:Rolapitant 3159:Netupitant 3154:Maropitant 3144:Aprepitant 2945:Dronabinol 2905:Olanzapine 2870:Zatosetron 2860:Ricasetron 2855:Ramosetron 2850:Quetiapine 2830:Olanzapine 2815:Lerisetron 2805:Dolasetron 2785:Bemesetron 2545:Stimulants 2525:Nootropics 2499:Deliriants 2474:Entheogens 2409:Anorectics 2387:Analgesics 2240:Alkylating 2173:Antivirals 2128:infections 2002:Emollients 1856:Coagulants 1726:metabolism 1671:2021-03-09 1613:(1): 177. 1517:2019-12-16 1267:2024-08-18 1138:2024-06-28 1113:2019-02-21 1084:2019-02-21 1009:2013-12-01 873:2015-10-09 753:(1): 3–5. 729:References 678:Peppermint 524:Dronabinol 513:Schedule I 493:(Vistaril) 451:Doxylamine 441:(Benadryl) 394:Rolapitant 388:Casopitant 378:Aprepitant 345:Alizapride 325:Olanzapine 320:Droperidol 316:(Motilium) 234:Dolasetron 157:analgesics 130:antiemetic 76:newspapers 3200:Midazolam 3195:Lorazepam 3069:Meclizine 3049:Cyclizine 2890:Clozapine 2820:Mianserin 2800:Dazopride 2795:Clozapine 2780:Azasetron 2775:Alosetron 2695:ATC codes 2661:Dressings 2646:Antidotes 2510:Sedatives 2506:Hypnotics 2215:malignant 2072:endocrine 1918:Diuretics 1851:Platelets 1811:and blood 1770:Laxatives 1660:Gov, Us. 1629:1471-2253 1559:0007-0912 1368:0923-7534 1309:2319-9644 1225:0306-4603 1178:1473-7175 1045:1179-1950 826:1469-493X 769:0974-2700 652:gingerols 581:Compazine 577:Lorazepam 567:Midazolam 479:Meclizine 434:Cyclizine 327:(Zyprexa) 224:dry mouth 204:serotonin 3220:Category 3205:Propofol 3101:Atropine 2959:cannabis 2950:Nabilone 2931:agonists 2540:Serenics 2205:Vaccines 1972:Fibrates 1794:Vitamins 1744:Antacids 1647:31521119 1567:10793599 1504:19187673 1496:23550785 1476:Nutr Rev 1414:16364290 1376:17108149 1327:26985431 1243:30412908 1186:21456949 1061:22426920 984:17587360 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