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Also like mammals, zebrafish store excess lipids in visceral, intramuscular, and subcutaneous adipose deposits. These reasons and others make zebrafish good models for studying obesity in humans and other species. Genetic obesity is usually studied in transgenic or mutated zebrafish with obesogenic genes. As an example, transgenic zebrafish with overexpressed AgRP, an endogenous melanocortin antagonist, showed increased body weight and adipose deposition during growth. Though zebrafish genes may not be the exact same as human genes, these tests could provide important insight into possible genetic causes and treatments for human genetic obesity. Diet-induced obesity zebrafish models are useful, as diet can be modified from a very early age. High fat diets and general overfeeding diets both show rapid increases in adipose deposition, increased BMI, hepatosteatosis, and hypertriglyceridemia. However, the normal fat, overfed specimens are still metabolically healthy, while high-fat diet specimens are not. Understanding differences between types of feeding-induced obesity could prove useful in human treatment of obesity and related health conditions.
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insulin are two examples of those such cells. This structure of the pancreas, along with the glucose homeostasis system, are helpful in studying diseases, such as diabetes, that are related to the pancreas. Models for pancreas function, such as fluorescent staining of proteins, are useful in determining the processes of glucose homeostasis and the development of the pancreas. Glucose tolerance tests have been developed using zebrafish, and can now be used to test for glucose intolerance or diabetes in humans. The function of insulin are also being tested in zebrafish, which will further contribute to human medicine. The majority of work done surrounding knowledge on glucose homeostasis has come from work on zebrafish transferred to humans.
2006:
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2293:(DM1) pathogenesis. More recently, Todd et al. described a new zebrafish model designed to explore the impact of CUG repeat expression during early development in DM1 disease. Zebrafish is also an excellent animal model to study congenital muscular dystrophies including CMD Type 1 A (CMD 1A) caused by mutation in the human laminin α2 (LAMA2) gene. The zebrafish, because of its advantages discussed above, and in particular the ability of zebrafish embryos to absorb chemicals, has become a model of choice in screening and testing new drugs against muscular dystrophies.
2215:
633:. Researchers have been able to collect 10,000 embryos in 10 minutes using this method. In particular, one pair of adult fish is capable of laying 200–300 eggs in one morning in approximately 5 to 10 at time. Male zebrafish are furthermore known to respond to more pronounced markings on females, i.e., "good stripes", but in a group, males will mate with whichever females they can find. What attracts females is not currently understood. The presence of plants, even plastic plants, also apparently encourages spawning.
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potential to improve the understanding of the interaction of the drug with the biological system by mathematical quantification and subsequent prediction to new situations, like new drugs or new organisms or patients. Using these computational methods, the previously mentioned analysis of paracetamol internal exposure in zebrafish larvae showed reasonable correlation between paracetamol clearance in zebrafish with that of higher vertebrates, including humans.
2140:. In one study, the model was used as a tool to understand the functional importance of genes known to be amplified and overexpressed in human melanoma. One gene, SETDB1, markedly accelerated tumor formation in the zebrafish system, demonstrating its importance as a new melanoma oncogene. This was particularly significant because SETDB1 is known to be involved in the epigenetic regulation that is increasingly appreciated to be central to tumor cell biology.
64:
1004:
2086:. Systems biology characterizes (part of) an organism by a mathematical description of all relevant processes. These can be for example different signal transduction pathways that upon a specific signal lead to a certain response. By quantifying these processes, their behaviour in healthy and diseased situation can be understood and predicted. Pharmacometrics uses data from preclinical experiments and
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small cells (3.25 h panel). The cells then migrate down the sides of the yolk (8 h panel) and begin forming a head and tail (16 h panel). The tail then grows and separates from the body (24 h panel). The yolk shrinks over time because the fish uses it for food as it matures during the first few days (72 h panel). After a few months, the adult fish reaches reproductive maturity (bottom panel).
40:
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testing, and exhibits a diurnal sleep cycle with similarities to mammalian sleep behavior. However, zebrafish are not a universally ideal research model; there are a number of disadvantages to their scientific use, such as the absence of a standard diet and the presence of small but important differences between zebrafish and mammals in the roles of some genes related to human disorders.
2044:. To date, 65 small-molecule screens have been carried out and at least one has led to clinical trials. Within these screens, many technical challenges remain to be resolved, including differing rates of drug absorption resulting in levels of internal exposure that cannot be extrapolated from the water concentration, and high levels of natural variation between individual animals.
2230:-sensitive cells supplementing the red, green and blue cone cell subtypes found in humans. Zebrafish can thus observe a very wide spectrum of colours. The species is also studied to better understand the development of the retina; in particular, how the cone cells of the retina become arranged into the so-called 'cone mosaic'. Zebrafish, in addition to certain other
1811:. Exposure of zebrafish to environmental stress induced by the chemical clotrimazole, an imidazole fungicide used in agriculture and in veterinary and human medicine, amplified the effects of inbreeding on key reproductive traits. Embryo viability was significantly reduced in inbred exposed fish and there was a tendency for inbred males to sire fewer offspring.
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in the eyes of humans aged from 18 months to 91 years, and were able to develop them into all types of retinal neurons. They were also able to grow them easily in the lab. The stem cells successfully migrated into diseased rats' retinas, and took on the characteristics of the surrounding neurons. The
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analysis. Because of its small size, however, it is very challenging to quantify the internal drug exposure. Traditionally multiple blood samples would be drawn to characterize the drug concentration profile over time, but this technique remains to be developed. To date, only a single pharmacokinetic
507:. There is usually some vegetation, either submerged or overhanging from the banks, and the bottom is sandy, muddy or silty, often mixed with pebbles or gravel. In surveys of zebrafish locations throughout much of its Bangladeshi and Indian distribution, the water had a near-neutral to somewhat basic
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Zebrafish have been used as model organisms for bone metabolism, tissue turnover, and resorbing activity. These processes are largely evolutionary conserved. They have been used to study osteogenesis (bone formation), evaluating differentiation, matrix deposition activity, and cross-talk of skeletal
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of specific genes or block other processes from occurring on RNA. MO can be injected into one cell of an embryo after the 32-cell stage, reducing gene expression in only cells descended from that cell. However, cells in the early embryo (less than 32 cells) are permeable to large molecules, allowing
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and mostly ranged from 16.5 to 34 °C (61.7–93.2 °F) in temperature. One unusually cold site was only 12.3 °C (54.1 °F) and another unusually warm site was 38.6 °C (101.5 °F), but the zebrafish still appeared healthy. The unusually cold temperature was at one of the
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Zebrafish have been used as a model system to study obesity, with research into both genetic obesity and over-nutrition induced obesity. Obese zebrafish, similar to obese mammals, show dysregulation of lipid controlling metabolic pathways, which leads to weight gain without normal lipid metabolism.
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Zebrafish pancreas development is very homologous to mammals, such as mice. The signaling mechanisms and way the pancreas functions are very similar. The pancreas has an endocrine compartment, which contains a variety of cells. Pancreatic PP cells that produce polypeptides, and β-cells that produce
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The zebrafish and zebrafish larva is a suitable model organism for drug discovery and development. As a vertebrate with 70% genetic homology with humans, it can be predictive of human health and disease, while its small size and fast development facilitates experiments on a larger and quicker scale
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embryo. The zebrafish embryos are transparent and they develop outside of the uterus, which allows scientists to study the details of development starting from fertilization and continuing throughout development. The zebrafish is also demonstrably similar to mammalian models and humans in toxicity
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In probing disorders of the nervous system, including neurodegenerative diseases, movement disorders, psychiatric disorders and deafness, researchers are using the zebrafish to understand how the genetic defects underlying these conditions cause functional abnormalities in the human brain, spinal
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The zebrafish embryo develops rapidly, with precursors to all major organs appearing within 36 hours of fertilization. The embryo begins as a yolk with a single enormous cell on top (see image, 0 h panel), which divides into two (0.75 h panel) and continues dividing until there are thousands of
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studies, including the development of higher-throughput, automated investigative tools. As demonstrated through ongoing research programmes, the zebrafish model enables researchers not only to identify genes that might underlie human disease, but also to develop novel therapeutic agents in drug
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of zebrafish function as a protective external layer and are little bony plates made by osteoblasts. These exoskeletal structures are formed by bone matrix depositing osteoblasts and are remodeled by osteoclasts. The scales also act as the main calcium storage of the fish. They can be cultured
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origin. The zebrafish can reach up to 4–5 cm (1.6–2.0 in) in length, although they typically are 1.8–3.7 cm (0.7–1.5 in) in the wild with some variations depending on location. Its lifespan in captivity is around two to three years, although in ideal conditions, this may be
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from the body, or its interaction with the target to achieve a certain effect. By quantifying these processes, their behaviour after different doses or in different patients can be understood and predicted to new doses or patients. By integrating these two fields, systems pharmacology has the
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in Delhi, India, announced the sequencing of the genome of a wild zebrafish strain, containing an estimated 1.7 billion genetic letters. The genome of the wild zebrafish was sequenced at 39-fold coverage. Comparative analysis with the zebrafish reference genome revealed over 5 million single
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imaging and genetic dissection of host-pathogen interactions. Zebrafish models for a wide range of bacterial, viral and parasitic pathogens have already been established; for example, the zebrafish model for tuberculosis provides fundamental insights into the mechanisms of pathogenesis of
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to occur. Zebrafish are asynchronous spawners and under optimal conditions (such as food availability and favorable water parameters) can spawn successfully frequently, even on a daily basis. Females are able to spawn at intervals of two to three days, laying hundreds of eggs in each
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Zebrafish has been extensively used as a model organism to study vertebrate innate immunity. The innate immune system is capable of phagocytic activity by 28 to 30 h postfertilization (hpf) while adaptive immunity is not functionally mature until at least 4 weeks postfertilization.
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To understand drug effects, the internal drug exposure is essential, as this drives the pharmacological effect. Translating experimental results from zebrafish to higher vertebrates (like humans) requires concentration-effect relationships, which can be derived from
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cell using a chemical screening approach. This revealed that an inhibition of the DHODH protein (by a small molecule called leflunomide) prevented development of the neural crest stem cells which ultimately give rise to melanoma via interference with the process of
2189:, a major underpinning process in many diseases, researchers have established a zebrafish model of inflammation, and its resolution. This approach allows detailed study of the genetic controls of inflammation and the possibility of identifying potential new drugs.
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genes, a sequence resembling vertebrate origin of light strand replication is found. It is difficult to draw evolutionary conclusions because it is difficult to determine whether base pair changes have adaptive significance via comparisons with other vertebrates'
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species. Given the opportunity, adults eat hatchlings, which may be protected by separating the two groups with a net, breeding box or separate tank. In captivity, zebrafish live approximately forty-two months. Some captive zebrafish can develop a curved spine.
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Zebrafish are hardy fish and considered good for beginner aquarists. Their enduring popularity can be attributed to their playful disposition, as well as their rapid breeding, aesthetics, cheap price and broad availability. They also do well in schools or
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pollution in lakes and rivers, which is linked to male infertility. The researchers cloned oestrogen-sensitive genes and injected them into the fertile eggs of zebrafish. The modified fish turned green if placed into water that was polluted by oestrogen.
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Canedo A, Rocha TL. Zebrafish (Danio rerio) using as model for genotoxicity and DNA repair assessments: Historical review, current status and trends. Sci Total
Environ. 2021 Mar 25;762:144084. doi: 10.1016/j.scitotenv.2020.144084. Epub 2020 Dec 14. PMID
2277:(MD) are a heterogeneous group of genetic disorders that cause muscle weakness, abnormal contractions and muscle wasting, often leading to premature death. Zebrafish is widely used as model organism to study muscular dystrophies. For example, the
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alternate and repeat as well. They found that there was less reliance on U2AF2 protein than in humans, in which the protein is required for the splicing process to occur. The pattern of repeating base pairs around introns that alters RNA
1980:
Zebrafish have been used as a model for studying DNA repair pathways. Embryos of externally fertilized fish species, such as zebrafish during their development, are directly exposed to environmental conditions such as pollutants and
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have also been found to regenerate following damage or developmental disruption. Study of gene expression during regeneration has allowed for the identification of several important signaling pathways involved in the process, such as
2035:
Drug screens in zebrafish can be used to identify novel classes of compounds with biological effects, or to repurpose existing drugs for novel uses; an example of the latter would be a screen which found that a commonly used statin
2136:, these tumors strongly resemble the human disease, are fully transplantable, and exhibit large-scale genomic alterations. The BRAF melanoma model was utilized as a platform for two screens published in March 2011 in the journal
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Zebrafish have been used as a model system to study epilepsy. Mammalian seizures can be recapitulated molecularly, behaviorally, and electrophysiologically, using a fraction of the resources required for experiments in mammals.
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1772:. This indicates that an evolutionary change in tetrapods may have led to humans relying on the U2AF2 protein for RNA splicing while these genes in zebrafish undergo splicing regardless of the presence of the protein.
2306:) osteoblast formation during bone development. They start mineralising bone elements as early as 4 days post fertilisation. Recently, adult zebrafish are being used to study complex age related bone diseases such as
6780:
Dey A, Flajšhans M, Pšenička M, Gazo I. DNA repair genes play a variety of roles in the development of fish embryos. Front Cell Dev Biol. 2023 Mar 1;11:1119229. doi: 10.3389/fcell.2023.1119229. PMID 36936683; PMCID:
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occurs at the site of the amputation, switching the zebrafish's cells to an "active", regenerative, stem cell-like state. In 2012, Australian scientists published a study revealing that zebrafish use a specialised
628:
To encourage the fish to spawn, some researchers use a fish tank with a sliding bottom insert, which reduces the depth of the pool to simulate the shore of a river. Zebrafish spawn best in the morning due to their
487:. The New Mexico population had been extirpated by 2003 and it is unclear if the others survive, as the last published records were decades ago. Elsewhere the species has been introduced to Colombia and Malaysia.
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ex-vivo (kept alive outside of the organism) in a multi-well plate, which allows manipulation with drugs and even screening for new drugs that could change bone metabolism (between osteoblasts and osteoclasts).
553:. The individuals showed a capacity to remember context with respect to objects, locations and occasions (what, when, where). Episodic memory is a capacity of explicit memory systems, typically associated with
2451:
Whiteley, Andrew R.; Bhat, Anuradha; Martins, Emilia P.; Mayden, Richard L.; Arunachalam, M.; Uusi-Heikkilä, Silva; Ahmed, A. T. A.; Shrestha, Jiwan; Clark, Matthew; Stemple, Derek; Bernatchez, Louis (2011).
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Witten PE, Hansen A, Hall BK (December 2001). "Features of mono- and multinucleated bone resorbing cells of the zebrafish Danio rerio and their contribution to skeletal development, remodeling, and growth".
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In cardiovascular research, the zebrafish has been used to model human myocardial infarction model. The zebrafish heart completely regenerates after about 2 months of injury without any scar formation. The
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Forner-Piquer I, Santangeli S, Maradonna F, Rabbito A, Piscitelli F, Habibi HR, et al. (October 2018). "Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate".
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613:. Upon release, embryonic development begins; in absence of sperm, growth stops after the first few cell divisions. Fertilized eggs almost immediately become transparent, a characteristic that makes
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Using smart data analysis methods, pathophysiological and pharmacological processes can be understood and subsequently translated to higher vertebrates, including humans. An example is the use of
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mutation to make Casper strain fish that have no melanophores or iridophores, and are transparent into adulthood. These fish are characterized by uniformly pigmented eyes and translucent skin.
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nucleotide variations and over 1.6 million insertion deletion variations. The zebrafish reference genome sequence of 1.4GB and over 26,000 protein coding genes was published by
Kerstin Howe
1148:
is very rapid, and its embryos are relatively large, robust, and transparent, and able to develop outside their mother. Furthermore, well-characterized mutant strains are readily available.
5854:
Lister JA, Robertson CP, Lepage T, Johnson SL, Raible DW (September 1999). "nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate".
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As the immune system is relatively conserved between zebrafish and humans, many human infectious diseases can be modeled in zebrafish. The transparent early life stages are well suited for
520:
The zebrafish is named for the five uniform, pigmented, horizontal, blue stripes on the side of the body, which are reminiscent of a zebra's stripes, and which extend to the end of the
470:
regions. It has frequently been said to occur in
Myanmar (Burma), but this is entirely based on pre-1930 records and likely refers to close relatives only described later, notably
7599:
Novoa B, Figueras A (2012-01-01). "Zebrafish: Model for the Study of
Inflammation and the Innate Immune Response to Infectious Diseases". In Lambris JD, Hajishengallis G (eds.).
5889:
Lamason RL, Mohideen MA, Mest JR, Wong AC, Norton HL, Aros MC, et al. (December 2005). "SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans".
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cells, to create and isolate mutants modeling human bone diseases, and test new chemical compounds for the ability to revert bone defects. The larvae can be used to follow new (
2152:. Because this approach would aim to target the "identity" of the melanoma cell rather than a single genetic mutation, leflunomide may have utility in treating human melanoma.
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is the only natural DNA transposable element in vertebrates from which an autonomous member has been identified. Examples include the artificial interaction produced between
2090:
to characterize the pharmacological processes that are underlying the relation between the drug dose and its response or clinical outcome. These can be for example the drug
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similarly to other vertebrates. The Bruce et al. team are known for this area, and in Bruce et al. 2003 & Bruce et al. 2005 uncover the role of two of these elements in
1215:
ran an advertising campaign publicising its intention to study the applicability of this ability to humans, stating that it aimed to raise ÂŁ50 million in research funding.
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Brannen KC, Panzica-Kelly JM, Danberry TL, Augustine-Rauch KA (February 2010). "Development of a zebrafish embryo teratogenicity assay and quantitative prediction model".
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expression of recessive deleterious alleles. For zebrafish, inbreeding depression might be expected to be more severe in stressful environments, including those caused by
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gene was then characterized in humans and a one base pair difference was found to strongly segregate fair-skinned
Europeans and dark-skinned Africans. Zebrafish with the
8808:
de Vrieze E, van Kessel MA, Peters HM, Spanings FA, Flik G, Metz JR (February 2014). "Prednisolone induces osteoporosis-like phenotype in regenerating zebrafish scales".
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possible. In
January 2013, Japanese scientists genetically modified a transparent zebrafish specimen to produce a visible glow during periods of intense brain activity.
1300:
and traditional outbred stocks have not been developed for laboratory zebrafish, and the genetic variability of wild-type lines among institutions may contribute to the
8851:
de Vrieze E, Zethof J, Schulte-Merker S, Flik G, Metz JR (May 2015). "Identification of novel osteogenic compounds by an ex-vivo sp7:luciferase zebrafish scale assay".
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developed a new strain of zebrafish, named Casper, whose adult bodies had transparent skin. This allows for detailed visualization of cellular activity, circulation,
1462:
sequence. Its length is 16,596 base pairs. This is within 100 base pairs of other related species of fish, and it is notably only 18 pairs longer than the goldfish (
438:
The zebrafish is native to freshwater habitats in South Asia where it is found in India, Pakistan, Bangladesh, Nepal and Bhutan. The northern limit is in the South
6588:
8253:"Establishment and optimization of a high throughput setup to study Staphylococcus epidermidis and Mycobacterium marinum infection as a model for drug discovery"
1304:
in biomedical research. Genetic differences in wild-type lines among populations maintained at different research institutions have been demonstrated using both
7068:"Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude"
8390:
532:-shaped, with gold stripes between the blue stripes; the female has a larger, whitish belly and silver stripes instead of gold. Adult females exhibit a small
5949:
2729:
2218:
The development of a single zebrafish retina captured on a light sheet microscope approx. every 12 hours from 1.5 days to 3.5 days after birth of the embryo
1549:
1276:
cord and sensory organs. Researchers have also studied the zebrafish to gain new insights into the complexities of human musculoskeletal diseases, such as
512:
highest known zebrafish locations at 1,576 m (5,171 ft) above sea level, although the species has been recorded to 1,795 m (5,889 ft).
9016:
Kalueff AV, Stewart AM, Kyzar EJ, Cachat J, Gebhardt M, Landsman S, et al. (International
Zebrafish Neuroscience Research Consortium (ZNRC)) (2012).
3219:
Gerhard GS, Kauffman EJ, Wang X, Stewart R, Moore JL, Kasales CJ, et al. (2002). "Life spans and senescent phenotypes in two strains of
Zebrafish (
3184:
Spence R, Fatema MK, Reichard M, Huq KA, Wahab MA, Ahmed ZF, Smith C (2006). "The distribution and habitat preferences of the zebrafish in
Bangladesh".
1061:(commonly referred to as the TĂĽbingen/Boston screens). The fish has a dedicated online database of genetic, genomic, and developmental information, the
774:
forms of both the zebra and leopard pattern, along with long-finned strains, have been obtained via selective breeding programs for the aquarium trade.
1411:
started the zebrafish genome sequencing project in 2001, and the full genome sequence of the
Tuebingen reference strain is publicly available at the
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2206:
mycobacteria. Furthermore, robotic technology has been developed for high-throughput antimicrobial drug screening using zebrafish infection models.
10005:
4188:
5580:
4764:
9888:
9746:
4939:"Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity"
2964:
9118:
Kocher TD, Jeffery WR, Parichy DM, Peichel CL, Streelman JT, Thorgaard GH (2005). "Fish models for studying adaptive evolution and speciation".
7426:"Alpha-1 adrenergic signaling drives cardiac regeneration via extracellular matrix remodeling transcriptional program in zebrafish macrophages"
5119:
Crim MJ, Lawrence C (January 2021). "A fish is not a mouse: understanding differences in background genetics is critical for reproducibility".
2645:
2521:
9795:
9348:
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Dahm, Ralf; Geisler, Robert (2006-04-25). "Learning from Small Fry: The Zebrafish as a Genetic Model Organism for Aquaculture Fish Species".
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in the retina. These could be injected into the eye to treat diseases that damage retinal neurons—nearly every disease of the eye, including
1629:
is a popular approach to study the function of genes in zebrafish. Construction of transgenic zebrafish is rather easy by a method using the
1434:
1412:
7351:
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rescued the normal exploratory behavior. This demonstrates relationships between glucocorticoids, fluoxetine, and exploration in this fish.
9955:
9094:
6698:
Ziv, L.; Muto, A.; Schoonheim, P. J.; Meijsing, S. H.; Strasser, D.; Ingraham, H. A.; Schaaf, M. J. M.; Yamamoto, K. R.; Baier, H. (2012).
6648:
6147:
4980:"Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain"
3737:
621:. Sex determination of common laboratory strains was shown to be a complex genetic trait, rather than to follow a simple ZW or XY system.
7985:
Levraud JP, Palha N, Langevin C, Boudinot P (September 2014). "Through the looking glass: witnessing host-virus interplay in zebrafish".
2917:
Engeszer RE, Patterson LB, Rao AA, Parichy DM (2007). "Zebrafish in the wild: a review of natural history and new notes from the field".
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diffusion between cells. Guidelines for using Morpholinos in zebrafish describe appropriate control strategies. Morpholinos are commonly
782:
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to California, Connecticut, Florida and New Mexico in the United States, presumably by deliberate release by aquarists or by escape from
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1700:. This strain can be adapted to 37 °C (99 °F) warm water and the absence of an immune system makes the use of patient derived
9370:
4107:
3861:
3266:
Hamilton TJ, Myggland A, Duperreault E, May Z, Gallup J, Powell RA, et al. (November 2016). "Episodic-like memory in zebrafish".
9460:
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were among the earliest successful vertebrate clones created. Its importance has been consolidated by successful large-scale forward
5805:
Naiche, L.A.; Harrelson, Zachary; Kelly, Robert G.; Papaioannou, Virginia E. (2005-12-01). "T-Box Genes in Vertebrate Development".
5286:
Kimmel CB, Law RD (March 1985). "Cell lineage of zebrafish blastomeres. I. Cleavage pattern and cytoplasmic bridges between cells".
4448:
4390:"Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy"
9875:
9720:
5321:
Kimmel CB, Law RD (March 1985). "Cell lineage of zebrafish blastomeres. III. Clonal analyses of the blastula and gastrula stages".
2373:
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element which encodes a gene for a fully functional transposase capable of catalyzing transposition in the zebrafish germ lineage.
9901:
9759:
3711:
4790:"Activation of canonical Wnt/β-catenin signaling stimulates proliferation in neuromasts in the zebrafish posterior lateral line"
3014:
10000:
9048:
6420:"Teleost microbiomes: the state of the art in their characterization, manipulation and importance in aquaculture and fisheries"
1536:
5231:
Coe TS, Hamilton PB, Griffiths AM, Hodgson DJ, Wahab MA, Tyler CR (January 2009). "Genetic variation in strains of zebrafish (
9491:
9083:
8037:
3816:
1054:
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9764:
6055:"Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling"
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in 500pL directly into 1–2 cell stage zebrafish embryos. The morpholino is able to integrate into most cells of the embryo.
9980:
9344:
8351:"MIO-M1 cells and similar muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics"
3840:
3100:
9357:
2289:(DMD). The Machuca-Tzili and co-workers applied zebrafish to determine the role of alternative splicing factor, MBNL, in
2237:
This study of the zebrafish's retinal characteristics has also extrapolated into medical enquiry. In 2007, researchers at
9260:
7117:"Outside-In Systems Pharmacology Combines Innovative Computational Methods With High-Throughput Whole Vertebrate Studies"
6110:
Vejnar, Charles E.; Moreno-Mateos, Miguel A.; Cifuentes, Daniel; Bazzini, Ariel A.; Giraldez, Antonio J. (October 2016).
6066:
3360:
Selman K, Wallace RA, Sarka A, Qi X (November 1993). "Stages of oocyte development in the zebrafish, Brachydanio rerio".
1997:
have, in recent years, proven to be a useful model for assessing environmental pollutants that might cause DNA damage.
1642:
9304:
8759:"Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds"
6803:"High-Throughput Video Processing of Heart Rate Responses in Multiple Wild-type Embryonic Zebrafish per Imaging Field"
2861:
9995:
9975:
7624:
3131:
Spence R, Gerlach G, Lawrence C, Smith C (February 2008). "The behaviour and ecology of the zebrafish, Danio rerio".
9914:
9821:
8400:
6521:
4331:"Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle"
1986:
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4007:
Dubińska-Magiera M, Daczewska M, Lewicka A, Migocka-Patrzałek M, Niedbalska-Tarnowska J, Jagla K (November 2016).
9960:
9800:
7938:"Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model"
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2143:
In another study, an effort was made to therapeutically target the genetic program present in the tumor's origin
1808:
1408:
778:
1305:
4890:"Mechanisms of Pathology-Induced Neural Stem Cell Plasticity and Neural Regeneration in Adult Zebrafish Brain"
9932:
9453:
4831:"Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line"
3315:
1673:
1062:
798:
376:
5751:
Schier, Alexander F.; Talbot, William S. (2005-12-01). "Molecular Genetics of Axis Formation in Zebrafish".
1226:
neurons following injury, which has been shown to be mediated by the dedifferentiation and proliferation of
696:
of six or more, and interact well with other fish species in the aquarium. However, they are susceptible to
9411:
8514:"Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1"
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3513:
1204:
1155:
techniques to be used, and the fact that its two-celled embryo can be fused into a single cell to create a
588:
Stages of zebrafish development. Photos to scale except adult, which is about 2.5 cm (1 in) long.
4613:"Late-stage neuronal progenitors in the retina are radial MĂĽller glia that function as retinal stem cells"
1234:
the dorsal and ventral tail fins and analyze their regrowth to test for mutations. It has been found that
1151:
Other advantages include the species' nearly constant size during early development, which enables simple
9990:
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9655:
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mechanism involved in this process was identified in a 2023 study. Zebrafish is also used as a model for
2162:
1427:
1065:(ZFIN). The Zebrafish International Resource Center (ZIRC) is a genetic resource repository with 29,250
786:
723:
The zebra danio was also used to make genetically modified fish and were the first species to be sold as
9660:
5605:
5170:
Whiteley AR, Bhat A, Martins EP, Mayden RL, Arunachalam M, Uusi-Heikkilä S, et al. (October 2011).
4208:
1179:
during their larval stages. The cardiac regenerative process likely involves signaling pathways such as
6657:
6360:"Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish"
5816:
5762:
5577:
4978:
Bhattarai P, Cosacak MI, Mashkaryan V, Demir S, Popova SD, Govindarajan N, et al. (January 2020).
4756:
2149:
2005:
1384:
1281:
744:
720:
They can range from a few centimeters to a few inches, and provide movement in a freshwater fish tank.
20:
9919:
9826:
8251:
Veneman WJ, MarĂn-Juez R, de Sonneville J, Ordas A, Jong-Raadsen S, Meijer AH, Spaink HP (June 2014).
6014:"Tol2 transposon-mediated enhancer trap to identify developmentally regulated zebrafish genes in vivo"
2960:
462:(lower Ganges basin) of India. Its range further south is more local, with scattered records from the
9516:
9498:
9286:
7603:. Advances in Experimental Medicine and Biology. Vol. 946. Springer New York. pp. 253–275.
7231:"The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset"
6424:
5807:
5753:
2238:
2091:
740:
210:
7550:
Le Guyader D, Redd MJ, Colucci-Guyon E, Murayama E, Kissa K, Briolat V, et al. (January 2008).
3862:"In Memory of George Streisinger, "Founding Father" of Zebrafish Developmental and Genetic Research"
3403:
Aleström P, D'Angelo L, Midtlyng PJ, Schorderet DF, Schulte-Merker S, Sohm F, Warner S (June 2020).
1391:, a number of commercially available global platforms exist for analysis of both gene expression by
9511:
9446:
7229:
Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, et al. (March 2011).
4559:
2513:
2429:
2346:
2125:
2095:
1269:
1244:
1212:
368:
6801:
Martin WK, Tennant AH, Conolly RB, Prince K, Stevens JS, DeMarini DM, et al. (January 2019).
6418:
Llewellyn, Martin S.; Boutin, SĂ©bastien; Hoseinifar, Seyed Hossein; Derome, Nicolas (2014-06-02).
5973:"A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish"
1944:
consistently proves to be a useful model for mammals in many cases and there is dramatically more
88:
10015:
9555:
8563:"The expanding phenotype of laminin alpha2 chain (merosin) abnormalities: case series and review"
8416:"Diagnosis and cell-based therapy for Duchenne muscular dystrophy in humans, mice, and zebrafish"
7343:
7199:
4727:
4563:
2311:
2174:
1982:
1961:
1926:
1196:
1180:
1141:
9102:
6860:"Automated Morphological Feature Assessment for Zebrafish Embryo Developmental Toxicity Screens"
6358:
Bickley LK, Brown AR, Hosken DJ, Hamilton PB, Le Page G, Paull GC, et al. (February 2013).
6111:
4138:"Model organisms in the fight against muscular dystrophy: lessons from drosophila and Zebrafish"
2023:
discovery programmes. Zebrafish embryos have proven to be a rapid, cost-efficient, and reliable
10010:
9985:
9893:
9787:
9751:
9595:
9548:
8020:
Ramakrishnan L (2013). "Looking within the Zebrafish to Understand the Tuberculous Granuloma".
7066:
Kantae V, Krekels EH, Ordas A, González O, van Wijk RC, Harms AC, et al. (December 2016).
4329:
Jurynec MJ, Xia R, Mackrill JJ, Gunther D, Crawford T, Flanigan KM, et al. (August 2008).
3733:
1895:
1451:
1169:
693:
641:
576:
consistent with looming objects by Temizer et al. 2015, Dunn et al. 2016, and Yao et al. 2016.
533:
372:
9420:
8200:
Spaink HP, Cui C, Wiweger MI, Jansen HJ, Veneman WJ, MarĂn-Juez R, et al. (August 2013).
7656:
Meeker ND, Trede NS (2008). "Immunology and zebrafish: spawning new models of human disease".
4388:
Rederstorff M, Castets P, Arbogast S, Lainé J, Vassilopoulos S, Beuvin M, et al. (2011).
3071:
1548:. (In Bruce et al. 2003 they failed to support the possibility that Eomesodermin behaves like
1136:
As a model biological system, the zebrafish possesses numerous advantages for scientists. Its
9813:
9633:
9075:
9068:
7528:
7286:
White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, et al. (March 2011).
5552:
1800:
1654:
1483:
1184:
1117:
1109:
1085:
352:
193:
9777:
9367:
8561:
Jones KJ, Morgan G, Johnston H, Tobias V, Ouvrier RA, Wilkinson I, North KN (October 2001).
8463:
Machuca-Tzili LE, Buxton S, Thorpe A, Timson CM, Wigmore P, Luther PK, Brook JD (May 2011).
8349:
Lawrence JM, Singhal S, Bhatia B, Keegan DJ, Reh TA, Luthert PJ, et al. (August 2007).
5629:
Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, et al. (April 2013).
4456:
747:
became commercially available in the United States. The fluorescent strains are trade-named
9681:
9642:
9534:
7299:
7242:
6814:
6704:
6525:
6371:
6070:
5898:
5824:
5770:
5642:
5356:
Stainier DY, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, et al. (October 2017).
5244:
5187:
4842:
4673:
4401:
4342:
4293:
3963:
3904:
3869:
3865:
3758:
Watanabe M, Iwashita M, Ishii M, Kurachi Y, Kawakami A, Kondo S, Okada N (September 2006).
3599:
3193:
2469:
2250:
2075:
1913:
1587:
1541:
1519:
1392:
1050:
975:
637:
4457:
3893:"Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays"
1739:. These genes have the DNA base pairs AC and TG as repeated sequences at the ends of each
1144:, and it has well-understood, easily observable and testable developmental behaviors. Its
8:
9562:
9541:
9432:
7424:
Apaydin, Onur; Altaikyzy, Akerke; Filosa, Alessandro; Sawamiphak, Suphansa (2023-11-20).
7177:
7115:
Schulthess P, van Wijk RC, Krekels EH, Yates JW, Spaink HP, van der Graaf PH (May 2018).
4526:"An Evolving Role for Notch Signaling in Heart Regeneration of the Zebrafish Danio rerio"
4009:"Zebrafish: A Model for the Study of Toxicants Affecting Muscle Development and Function"
1854:
1701:
1689:
1661:
1416:
1333:
1235:
1219:
1125:
1043:
53:
8202:"Robotic injection of zebrafish embryos for high-throughput screening in disease models"
7303:
7246:
6818:
6665:
6586:) as a model organism, with emphasis on applications for finfish aquaculture research".
6529:
6375:
6217:
Lin CL, Taggart AJ, Lim KH, Cygan KJ, Ferraris L, Creton R, et al. (January 2016).
5902:
5646:
5248:
5191:
4937:
Cosacak MI, Bhattarai P, Reinhardt S, Petzold A, Dahl A, Zhang Y, Kizil C (April 2019).
4846:
4677:
4405:
4346:
4297:
3967:
3908:
3760:"Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene"
3603:
3329:
3310:
3197:
2473:
9426:
9240:
9143:
9040:
8988:
8961:
8937:
8910:
8833:
8785:
8758:
8731:
8704:
8685:
8636:
8611:
8587:
8562:
8538:
8513:
8489:
8464:
8440:
8415:
8326:
8301:
8277:
8252:
8177:
8152:
8128:
8103:
7962:
7937:
7862:
7841:
7817:
7790:
7766:
7741:
7717:
7692:
7638:
7581:
7506:
7463:
7401:
7374:
7320:
7287:
7263:
7230:
7141:
7116:
7092:
7067:
7045:
6994:
6969:
6884:
6859:
6835:
6802:
6755:
6742:
6699:
6685:
6646:(2015). "Addressing the Genetics of Human Mental Health Disorders in Model Organisms".
6617:
6557:
6473:
6460:
6419:
6392:
6359:
6340:
6292:
6267:
6243:
6218:
6194:
6170:"Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish"
6169:
6092:
5922:
5663:
5630:
5503:
Tan PK, Downey TJ, Spitznagel EL, Xu P, Fu D, Dimitrov DS, et al. (October 2003).
5480:
5453:
5429:
5408:
5384:
5357:
5268:
5208:
5171:
5152:
5055:
5030:
5006:
4979:
4914:
4889:
4865:
4830:
4704:
4691:
4661:
4637:
4612:
4501:
4476:
4424:
4389:
4365:
4330:
4257:
4230:
4164:
4137:
4084:
4059:
4035:
4008:
3984:
3951:
3927:
3892:
3784:
3759:
3623:
3491:
3478:
3453:
3429:
3404:
3385:
3342:
3291:
3248:
3166:
2942:
2781:
2752:
2695:
2670:
2620:
2595:
2490:
2453:
2367:
2315:
2290:
2274:
1301:
1277:
1121:
1046:
480:
476:. Likewise, old records from Sri Lanka are highly questionable and remain unconfirmed.
219:
83:
9183:
9156:
5719:
5690:
5529:
5504:
3703:
3236:
2669:
White RM, Sessa A, Burke C, Bowman T, LeBlanc J, Ceol C, et al. (February 2008).
1284:, a biological signal that underlies a number of human cancers, controls cell growth.
9862:
9808:
9668:
9522:
9209:
9188:
9135:
9079:
8993:
8942:
8878:
8825:
8790:
8736:
8677:
8641:
8592:
8543:
8494:
8445:
8372:
8331:
8282:
8233:
8182:
8133:
8084:
8043:
8033:
8002:
7967:
7918:
7867:
7840:
Benard EL, van der Sar AM, Ellett F, Lieschke GJ, Spaink HP, Meijer AH (March 2012).
7822:
7771:
7722:
7673:
7630:
7620:
7573:
7498:
7467:
7455:
7447:
7406:
7325:
7268:
7181:
7146:
7097:
7037:
6999:
6950:
6889:
6840:
6747:
6729:
6677:
6669:
6609:
6549:
6541:
6465:
6447:
6397:
6383:
6332:
6297:
6248:
6199:
6139:
6131:
6084:
6035:
5994:
5914:
5871:
5836:
5828:
5782:
5774:
5724:
5668:
5534:
5485:
5434:
5389:
5338:
5334:
5303:
5299:
5260:
5213:
5199:
5156:
5144:
5136:
5101:
5060:
5011:
4960:
4919:
4870:
4811:
4709:
4642:
4525:
4506:
4429:
4370:
4311:
4262:
4169:
4089:
4040:
3989:
3932:
3812:
3789:
3685:
3680:
3663:
3615:
3571:
3483:
3434:
3377:
3334:
3283:
3240:
3205:
3158:
3144:
3010:
2934:
2834:
2786:
2700:
2625:
2495:
2481:
2406:
2121:
1907:
1883:
1459:
630:
455:
447:
422:
9647:
9438:
9244:
9147:
9017:
8837:
8689:
8300:
Allison WT, Barthel LK, Skebo KM, Takechi M, Kawamura S, Raymond PA (October 2010).
7887:"Real-time imaging and genetic dissection of host-microbe interactions in zebrafish"
7510:
6759:
6689:
6621:
6561:
6477:
6315:
Charlesworth D, Willis JH (November 2009). "The genetics of inbreeding depression".
6096:
5272:
3627:
3495:
3389:
3346:
3252:
3170:
2946:
2234:
fish, are particularly noted for having extreme precision of cone cell arrangement.
9867:
9853:
9673:
9578:
9388:
9230:
9178:
9168:
9127:
9032:
8983:
8973:
8932:
8922:
8868:
8860:
8817:
8780:
8770:
8726:
8716:
8669:
8631:
8623:
8582:
8574:
8533:
8525:
8484:
8476:
8465:"Zebrafish deficient for Muscleblind-like 2 exhibit features of myotonic dystrophy"
8435:
8427:
8362:
8321:
8313:
8272:
8264:
8223:
8213:
8172:
8164:
8123:
8115:
8074:
8025:
7994:
7957:
7949:
7908:
7898:
7857:
7849:
7812:
7802:
7761:
7753:
7712:
7704:
7665:
7642:
7612:
7604:
7585:
7563:
7490:
7437:
7396:
7386:
7315:
7307:
7258:
7250:
7173:
7136:
7128:
7087:
7079:
7049:
7029:
6989:
6981:
6942:
6879:
6871:
6830:
6822:
6737:
6721:
6713:
6661:
6601:
6597:
6533:
6455:
6437:
6387:
6379:
6324:
6287:
6279:
6238:
6230:
6189:
6181:
6123:
6074:
6025:
5984:
5926:
5906:
5863:
5820:
5766:
5714:
5706:
5658:
5650:
5524:
5516:
5475:
5465:
5424:
5416:
5379:
5369:
5330:
5295:
5252:
5203:
5195:
5128:
5091:
5050:
5042:
5001:
4991:
4950:
4909:
4901:
4860:
4850:
4801:
4699:
4681:
4632:
4628:
4624:
4496:
4488:
4419:
4409:
4360:
4350:
4301:
4252:
4242:
4200:
4159:
4149:
4079:
4071:
4030:
4020:
3979:
3971:
3922:
3912:
3779:
3771:
3675:
3607:
3561:
3473:
3465:
3424:
3416:
3369:
3324:
3295:
3275:
3232:
3201:
3148:
3140:
2926:
2824:
2776:
2768:
2690:
2682:
2615:
2611:
2607:
2596:"Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish"
2571:
2561:
2485:
2477:
2424:
2222:
Another notable characteristic of the zebrafish is that it possesses four types of
1945:
1725:
1708:
1376:
1325:
1074:
496:
411:
364:
311:
8705:"Zebrafish Models of Human Skeletal Disorders: Embryo and Adult Swimming Together"
6344:
5631:"The zebrafish reference genome sequence and its relationship to the human genome"
3891:
Xiang J, Yang H, Che C, Zou H, Yang H, Wei Y, et al. (2009). Isalan M (ed.).
584:
9415:
9393:
9374:
9361:
9308:
9290:
9173:
8627:
8612:"Recent advances using zebrafish animal models for muscle disease drug discovery"
8029:
8024:. Advances in Experimental Medicine and Biology. Vol. 783. pp. 251–66.
7608:
7568:
7551:
7442:
7425:
6858:
TeixidĂł E, KieĂźling TR, Krupp E, Quevedo C, Muriana A, Scholz S (February 2019).
6700:"An affective disorder in zebrafish with mutation of the glucocorticoid receptor"
6433:
5989:
5972:
5971:
Kawakami K, Takeda H, Kawakami N, Kobayashi M, Matsuda N, Mishina M (July 2004).
5695:) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA"
5609:
5584:
5505:"Evaluation of gene expression measurements from commercial microarray platforms"
5374:
4996:
4955:
4938:
4414:
4247:
4006:
3917:
3642:
3611:
2087:
2083:
2079:
2058:
2054:
2041:
1901:
1889:
1372:
1356:
1344:
767:
751:; other cultivated varieties include "golden", "sandy", "longfin" and "leopard".
593:
550:
319:
307:
8367:
8350:
8218:
8201:
7791:"Pathogen recognition and activation of the innate immune response in zebrafish"
7481:
Drummond IA (February 2005). "Kidney development and disease in the zebrafish".
7375:"The zebrafish heart regenerates after cryoinjury-induced myocardial infarction"
7020:
MacRae CA, Peterson RT (October 2015). "Zebrafish as tools for drug discovery".
6168:
Yan C, Brunson DC, Tang Q, Do D, Iftimia NA, Moore JC, et al. (June 2019).
4075:
3832:
2566:
2549:
2370:
or medaka, another fish used for genetic, developmental, and biomedical research
2112:
Zebrafish have been used to make several transgenic models of cancer, including
1423:
1368:
805:) provides up-to-date information about current known wild-type (WT) strains of
9965:
9573:
9470:
9354:
9252:
8864:
8395:
8079:
8062:
7757:
6985:
6826:
6185:
5589:
5132:
4835:
Proceedings of the National Academy of Sciences of the United States of America
4666:
Proceedings of the National Academy of Sciences of the United States of America
4335:
Proceedings of the National Academy of Sciences of the United States of America
2686:
2019:
1845:
distance from the most common aquaculture species. Because the most common are
1646:
1361:
1329:
1309:
1297:
1058:
1031:
771:
573:
348:
130:
9235:
9222:
9036:
8978:
8821:
8431:
8168:
7998:
7669:
6537:
5256:
5046:
4905:
4555:
4154:
3975:
3279:
2594:
Goldshmit Y, Sztal TE, Jusuf PR, Hall TE, Nguyen-Chi M, Currie PD (May 2012).
1804:
1355:
as DNA or RNA; by binding to complementary RNA sequences, they can reduce the
1191:
and their associated cardiac cilia by way of the mechanosensitive ion channel
9949:
9772:
9618:
8927:
8775:
7451:
7288:"DHODH modulates transcriptional elongation in the neural crest and melanoma"
6733:
6673:
6613:
6545:
6451:
6442:
6135:
5832:
5778:
5140:
3775:
3420:
3096:
2415:
1932:
1917:) – are less used normally but would be closer to particular target species.
1878:
1828:
1824:
1367:
A known problem with gene knockdowns is that, because the genome underwent a
1348:
1265:
1145:
992:
712:
703:
661:
618:
610:
565:
561:
554:
472:
467:
463:
392:
334:
322:
140:
73:
68:
9338:
8962:"Age Bias in Zebrafish Models of Epilepsy: What Can We Learn From Old Fish?"
8512:
Todd PK, Ackall FY, Hur J, Sharma K, Paulson HL, Dowling JJ (January 2014).
7693:"A model 450 million years in the making: zebrafish and vertebrate immunity"
7552:"Origins and unconventional behavior of neutrophils in developing zebrafish"
7391:
6875:
5910:
5867:
4855:
4686:
4355:
3952:"Zebrafish: A marvel of high-throughput biology for 21st century toxicology"
3566:
3549:
3373:
2772:
2671:"Transparent adult zebrafish as a tool for in vivo transplantation analysis"
2214:
1751:
alternate and repeat, and on the 5'ss (5' splicing site), their complements
541:
extended to over five years. In the wild it is typically an annual species.
525:
9485:
9301:
9192:
9139:
9131:
8997:
8946:
8882:
8829:
8794:
8740:
8721:
8681:
8645:
8596:
8547:
8498:
8449:
8376:
8335:
8286:
8237:
8228:
8186:
8137:
8088:
8047:
8006:
7971:
7922:
7871:
7826:
7775:
7726:
7677:
7634:
7577:
7502:
7494:
7459:
7410:
7329:
7272:
7185:
7150:
7101:
7041:
7003:
6954:
6932:
6893:
6844:
6751:
6681:
6553:
6469:
6401:
6336:
6301:
6252:
6203:
6143:
6127:
6088:
6039:
5998:
5918:
5875:
5840:
5786:
5728:
5672:
5538:
5489:
5438:
5393:
5264:
5217:
5148:
5105:
5064:
5015:
4964:
4923:
4874:
4815:
4757:"Study Reveals Secret of Zebrafish | Biochemistry | Sci-News.com"
4713:
4646:
4510:
4433:
4374:
4315:
4266:
4173:
4093:
4044:
3993:
3936:
3793:
3689:
3619:
3575:
3487:
3438:
3381:
3338:
3287:
3244:
3162:
2938:
2853:
2838:
2829:
2812:
2790:
2704:
2629:
2548:
Van Wijk RC, Krekels EH, Hankemeier T, Spaink HP, Van der Graaf PH (2017).
2499:
2378:
2307:
2186:
2170:
2144:
2037:
1820:
1736:
1531:
1396:
1320:
Due to their fast and short life cycles and relatively large clutch sizes,
1260:
1173:
1105:
1011:. A wild-type embryo (top) is shown for comparison. The mutant lacks black
676:
569:
504:
484:
8578:
7807:
7083:
6234:
5470:
5342:
5307:
3469:
3452:
Bradley K, Breyer P, Melville D, Broman K, Knapik E, Smith JR (Jun 2011).
2930:
1799:
When close relatives mate, progeny may exhibit the detrimental effects of
754:
668:, although they can eat a variety of other foods, such as worms and small
9733:
9627:
9505:
9380:
5520:
5096:
5080:"The zebrafish as a model for muscular dystrophy and congenital myopathy"
5079:
4025:
2262:
2227:
2166:
2063:
1965:
1874:
1784:
1680:
and many other phenomena. In 2019 researchers published a crossing of a
1280:. Another focus of zebrafish research is to understand how a gene called
1248:
1227:
1188:
1008:
657:
397:
338:
9044:
7913:
7311:
7254:
6935:
Birth Defects Research Part B: Developmental and Reproductive Toxicology
5654:
4695:
4204:
1606:
production, and confirmed its function with a Morpholino knockdown. The
9880:
9725:
9712:
9213:
8873:
8529:
8480:
8119:
7953:
7842:"Infection of zebrafish embryos with intracellular bacterial pathogens"
7708:
7616:
7373:
Chablais, Fabian; Veit, Julia; Rainer, Gregor; Jaźwińska, Anna (2011).
7132:
6946:
6725:
6643:
6079:
6054:
6030:
6013:
4806:
4789:
4492:
3588:
3040:, a new species of cyprinid species from Myitkyina, northern Myanmar".
2266:
team stated that they intended to develop the same approach in humans.
1990:
1969:
1937:
1788:
1677:
1660:
There are well-established protocols for editing zebrafish genes using
1607:
1594:
strain identified the gene responsible for its unusual pigmentation as
1527:
1492:
1475:
1379:, it is not always easy to silence the activity of one of the two gene
1352:
1337:
1252:
1156:
1097:
1093:
1042:
function. Its use as a laboratory animal was pioneered by the American
1035:
1016:
996:
736:
680:
669:
653:
640:(DINP), commonly used in a large variety of plastic items, disrupt the
528:
and laterally compressed, with its mouth directed upwards. The male is
521:
500:
459:
406:
402:
380:
360:
345:
315:
150:
8673:
8317:
7903:
7886:
7742:"Host-pathogen interactions made transparent with the zebrafish model"
6605:
5710:
4135:
4131:
4129:
3454:"A SNP-Based Linkage Map for Zebrafish Reveals Sex Determination Loci"
3402:
3153:
2576:
1419:. The zebrafish reference genome sequence is annotated as part of the
781:(CZRC), a non-profit organization, which was jointly supported by the
777:
Various transgenic and mutant strains of zebrafish were stored at the
9738:
9694:
4449:"Research Offers Clue Into How Hearts Can Regenerate in Some Species"
3550:"Zebrafish as a model vertebrate for investigating chemical toxicity"
2242:
2223:
2133:
2024:
1862:
1842:
1712:
1688:
strain that produced transparent, immunodeficient offspring, lacking
1664:
and this tool has been used to generate genetically modified models.
1626:
1340:
1256:
1187:; hemodynamic changes in the damaged heart are sensed by ventricular
1176:
1113:
601:
439:
100:
9589:
7033:
6328:
6283:
4306:
4281:
1003:
9847:
9707:
9699:
9612:
9474:
8250:
8153:"Protection and pathology in TB: learning from the zebrafish model"
7549:
6109:
4136:
Plantié E, Migocka-Patrzałek M, Daczewska M, Jagla K (April 2015).
4126:
4060:"Zebrafish Heart Regeneration as a Model for Cardiac Tissue Repair"
3109:
2258:
2254:
2129:
2117:
2113:
2010:
1877:, zebrafish results may not be perfectly applicable. Various other
1870:
1858:
1846:
1769:
1748:
1576:
mutation was identified in the zebrafish ortholog of the mammalian
1561:
1557:
1553:
1507:
1231:
1208:
1152:
1101:
1089:
698:
605:
537:
356:
326:
160:
120:
8414:
Kunkel LM, Bachrach E, Bennett RR, Guyon J, Steffen L (May 2006).
8268:
7344:"Arthritis Drug Could Help Beat Melanoma Skin Cancer, Study Finds"
5454:"In vivo testing of microRNA-mediated gene knockdown in zebrafish"
4662:"A histone demethylase is necessary for regeneration in zebrafish"
1728:
discovered that 10% of zebrafish genes do not need to rely on the
9927:
9402:
9397:
9202:
The Zebrafish Book: A guide for the laboratory use of zebrafish (
8850:
8807:
7853:
6907:
5420:
3644:
The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (
2231:
1866:
1765:
1756:
1752:
1744:
1732:
1603:
1595:
1545:
1479:
1420:
1387:
by the other paralog. Despite the complications of the zebrafish
1380:
1240:
1066:
1020:
1012:
748:
724:
529:
417:
9408:
7423:
7228:
4936:
2550:"Systems pharmacology of hepatic metabolism in zebrafish larvae"
2128:. Zebrafish expressing mutated forms of either the BRAF or NRAS
499:
clear water of quite shallow depth in streams, canals, ditches,
446:
river basin in the Pakistan–India border region to the state of
9686:
8462:
7839:
6417:
6011:
5970:
5804:
4977:
4387:
3514:"Birds Do It, Bees Do It, Even Zebrafish Do It—Just Too Little"
2649:
2547:
2246:
1740:
1697:
1693:
1599:
1523:
1515:
1388:
1223:
1137:
549:
In 2015, a study was published about zebrafishes' capacity for
451:
443:
110:
7285:
7114:
6582:
Ribas, Laia; Piferrer, Francesc (2013-07-31). "The zebrafish (
6112:"Optimized CRISPR–Cas9 System for Genome Editing in Zebrafish"
6012:
Parinov S, Kondrichin I, Korzh V, Emelyanov A (October 2004).
5409:"Microinjection of zebrafish embryos to analyze gene function"
4477:"Sensory hair cell regeneration in the zebrafish lateral line"
3265:
2400:
2398:
2396:
2394:
2132:
develop melanoma when placed onto a p53 deficient background.
1831:
causing yield loss or spreading to adjacent wild populations.
1324:
or zebrafish are a useful model for genetic studies. A common
987:
9528:
5602:
4611:
Bernardos RL, Barthel LK, Meyers JR, Raymond PA (June 2007).
4610:
4556:"Mending Broken Hearts (2011) British Heart Foundation TV ad"
1729:
1503:
1192:
672:, if their preferred food sources are not readily available.
665:
170:
39:
8104:"Fit for consumption: zebrafish as a model for tuberculosis"
8063:"The zebrafish guide to tuberculosis immunity and treatment"
7984:
6268:"Functional and evolutionary implications of gene orthology"
5853:
4728:"Organ Regeneration In Zebrafish: Unraveling The Mechanisms"
3757:
2722:"Researchers Capture A Zebrafish's Thought Process On Video"
1653:. Dorsky et al. 2002 investigated the developmental role of
1482:-coding genes and a noncoding control region containing the
1007:
A zebrafish pigment mutant (bottom) produced by insertional
9117:
8348:
7372:
7200:"Zebrafish model of human melanoma reveals new cancer gene"
6857:
5452:
Leong IU, Lan CC, Skinner JR, Shelling AN, Love DR (2012).
5230:
4659:
4231:"Let sleeping zebrafish lie: a new model for sleep studies"
3547:
3451:
2916:
2391:
1921:
1582:
1552:. Neither they nor anyone else has been able to locate any
1487:
1467:
1200:
1039:
802:
9283:
8413:
8299:
7065:
6800:
6357:
4586:"British Heart Foundation – The science behind the appeal"
3704:"Zebrafish - Danio rerio - Details - Encyclopedia of Life"
3218:
3130:
1474:). Its gene order and content are identical to the common
644:
and thereby affect reproduction in a sex-specific manner.
9015:
8560:
7884:
7788:
6697:
5169:
4660:
Stewart S, Tsun ZY, Izpisua Belmonte JC (November 2009).
4328:
3548:
Hill AJ, Teraoka H, Heideman W, Peterson RE (July 2005).
3133:
Biological Reviews of the Cambridge Philosophical Society
2857:
2450:
2245:
found in the eyes of fish and mammals that develops into
1989:. To cope with such DNA damages, a variety of different
1850:
564:
integrate a wide array of sensory stimuli to produce the
9320:
9302:
European Society for Fish Models in Biology and Medicine
9208:(5th ed.). Eugene, OR: University of Oregon Press.
7935:
5628:
4787:
2454:"Population genomics of wild and laboratory zebrafish (
1803:. Inbreeding depression is predominantly caused by the
1657:
by transgenically expressing a Lef1/β-catenin reporter.
770:
of the zebrafish which arose due to a pigment mutation.
9326:
9295:
7164:
Liu S, Leach SD (2011). "Zebrafish models for cancer".
6413:
6411:
6219:"RNA structure replaces the need for U2AF2 in splicing"
5942:"Scientists Create See-Through Fish, Watch Cancer Grow"
5888:
5451:
5172:"Population genomics of wild and laboratory zebrafish (
4828:
4282:"Lab animals: Standardize the diet for zebrafish model"
3183:
2593:
1556:
which – in the mother – will prevent initiation of the
636:
Exposure to environmentally relevant concentrations of
508:
9223:"Targeted gene modification can rewrite zebrafish DNA"
8702:
8199:
7936:
Torraca V, Masud S, Spaink HP, Meijer AH (July 2014).
7885:
Meijer AH, van der Vaart M, Spaink HP (January 2014).
6577:
6575:
6573:
6571:
5355:
4829:
Steiner AB, Kim T, Cabot V, Hudspeth AJ (April 2014).
4788:
Head JR, Gacioch L, Pennisi M, Meyers JR (July 2013).
1069:
available for distribution to the research community.
9468:
8302:"Ontogeny of cone photoreceptor mosaics in zebrafish"
6633:
6631:
5746:
5744:
5742:
5740:
5738:
5502:
3949:
3734:"Longfin Leopard Danio Fish Care Guide - The Pet Max"
3664:"A call to fins! Zebrafish as a gerontological model"
2750:
2668:
2514:"Breeding Zebrafish (Zebra danios) - The fish doctor"
1586:
result in eye defects and loss of pigment, a type of
450:
in northeast India. Its range is concentrated in the
7525:"Investigating inflammatory disease using zebrafish"
6495:
6493:
6491:
6489:
6487:
6408:
6259:
6046:
5800:
5798:
5796:
4470:
4468:
3950:
Bugel SM, Tanguay RL, Planchart A (September 2014).
3359:
3302:
1486:
for the heavy strand. In between a grouping of five
1203:
and activating various downstream effectors such as
9332:
9314:
8511:
8067:
Cold Spring Harbor Symposia on Quantitative Biology
6568:
5235:) and the implications for ecotoxicology studies".
4783:
4781:
2753:"Phylogeny of zebrafish, a "model species", within
2261:-related blindness. The researchers studied MĂĽller
2009:FDA research used Zebrafish to show the effects of
325:. Native to India and South Asia, it is a popular
9067:
9018:"Time to recognize zebrafish "affective" behavior"
8756:
6628:
6518:Australia New Zealand Marine Biotechnology Society
6314:
6216:
5735:
4279:
4108:"Adult Stem Cell Research Avoids Ethical Concerns"
3405:"Zebrafish: Housing and husbandry recommendations"
3311:"Zebrafish Behavior: Opportunities and Challenges"
495:Zebrafish typically inhabit moderately flowing to
415:. Zebrafish are also closely related to the genus
9345:FishMap: The Zebrafish Community Genomics Browser
6967:
6484:
5793:
5688:
5406:
4465:
3308:
2646:"Fudan scientists turn fish into estrogen alerts"
2000:
1743:. On the 3'ss (3' splicing site), the base pairs
458:basins, and the species was first described from
9947:
8959:
8908:
8658:
8391:"Zebra fish may point way to cure for blindness"
6167:
5689:Broughton RE, Milam JE, Roe BA (November 2001).
4778:
3005:
3003:
2883:
2881:
2879:
2813:"Evolution of danio pigment pattern development"
2652:. January 12, 2007. Retrieved November 15, 2012.
2296:
1834:This usefulness is less than it might be due to
1053:in the 1970s and 1980s; Streisinger's zebrafish
675:In research, adult zebrafish are often fed with
9074:. Edison, New Jersey: Chartwell Books. p.
8960:Cho SJ, Park E, Baker A, Reid AY (2020-09-10).
8911:"Zebrafish as a Model for Obesity and Diabetes"
7121:CPT: Pharmacometrics & Systems Pharmacology
7108:
4588:. Bhf.org.uk. February 16, 2007. Archived from
3890:
3634:
3507:
3505:
2912:
2910:
2908:
2906:
2904:
2902:
2887:
1614:mutation have since been bred with fish with a
8909:Zang L, Maddison LA, Chen W (20 August 2018).
7789:van der Vaart M, Spaink HP, Meijer AH (2012).
7061:
7059:
7019:
6265:
6052:
5684:
5682:
4474:
4280:Penglase S, Moren M, Hamre K (November 2012).
2984:
2982:
2806:
2804:
2802:
2800:
2430:10.2305/IUCN.UK.2010-4.RLTS.T166487A6219667.en
2404:
2345:Zebrafish have been used as a model system in
2285:) mutant is the zebrafish orthologue of human
2069:
2047:
1819:Zebrafish are common models for research into
344:The zebrafish is an important and widely used
9454:
9349:Institute of Genomics and Integrative Biology
7598:
7483:Journal of the American Society of Nephrology
6581:
5939:
5614:Institute of Genomics and Integrative Biology
5407:Rosen JN, Sweeney MF, Mably JD (March 2009).
5077:
3052:
3000:
2876:
2543:
2541:
2539:
1993:pathways are expressed during development.
1435:Institute of Genomics and Integrative Biology
1413:National Center for Biotechnology Information
1218:Zebrafish have also been found to regenerate
969:species may be fertile: for example, between
9389:Sanger Institute Zebrafish Mutation Resource
9253:"A Point Of View: Fly, Fish, Mouse and Worm"
8060:
8022:The New Paradigm of Immunity to Tuberculosis
8019:
7739:
7690:
6649:Annual Review of Genomics and Human Genetics
6641:
6351:
6308:
5750:
5358:"Guidelines for morpholino use in zebrafish"
5118:
5028:
3661:
3543:
3541:
3539:
3502:
3445:
2899:
2751:McCluskey BM, Postlethwait JH (March 2015).
1530:they find the T-box transcription activator
600:is three months. A male must be present for
9321:The Zebrafish International Resource Center
9199:
8966:Frontiers in Cell and Developmental Biology
8915:Frontiers in Cell and Developmental Biology
8101:
7655:
7056:
6968:Rennekamp AJ, Peterson RT (February 2015).
6499:
5679:
5624:
5622:
5593:. July 5, 2009. Retrieved February 5, 2013.
4013:International Journal of Molecular Sciences
3640:
3177:
3091:
3089:
2991:The behavior and ecology of the zebrafish,
2979:
2797:
2641:
2639:
2589:
2587:
2340:
2209:
1936:) which are quite close, both being in the
1667:
783:Ministry of Science and Technology of China
9461:
9447:
9284:British Association of Zebrafish Husbandry
6970:"15 years of zebrafish chemical screening"
6776:
6774:
6772:
5458:Journal of Biomedicine & Biotechnology
5035:Current Neurology and Neuroscience Reports
3854:
2988:
2536:
1787:, all of which cluster closely with other
1580:transcription factor. Mutations in human
1478:form of mitochondrial DNA. It contains 13
62:
38:
9355:WebHome Zebrafish GenomeWiki Beta Preview
9234:
9220:
9182:
9172:
8987:
8977:
8936:
8926:
8872:
8784:
8774:
8730:
8720:
8703:Carnovali M, Banfi G, Mariotti M (2019).
8635:
8586:
8537:
8488:
8439:
8366:
8325:
8276:
8227:
8217:
8176:
8127:
8078:
7961:
7912:
7902:
7861:
7816:
7806:
7765:
7716:
7567:
7441:
7400:
7390:
7319:
7262:
7140:
7091:
6993:
6883:
6834:
6741:
6514:Japanese Society for Marine Biotechnology
6510:European Society for Marine Biotechnology
6459:
6441:
6391:
6291:
6242:
6193:
6078:
6029:
5988:
5718:
5691:"The complete sequence of the zebrafish (
5662:
5528:
5479:
5469:
5428:
5383:
5373:
5320:
5285:
5207:
5095:
5054:
5031:"Modeling neurodegeneration in zebrafish"
5005:
4995:
4971:
4954:
4913:
4864:
4854:
4805:
4761:Breaking Science News | Sci-News.com
4703:
4685:
4636:
4500:
4423:
4413:
4364:
4354:
4305:
4256:
4246:
4163:
4153:
4083:
4057:
4034:
4024:
3983:
3926:
3916:
3783:
3679:
3565:
3536:
3477:
3428:
3328:
3152:
3042:Ichthyological Exploration of Freshwaters
2828:
2780:
2716:
2714:
2694:
2619:
2575:
2565:
2489:
2428:
2155:
1711:genetically modified zebrafish to detect
1602:carrier that appeared to be required for
1498:
568:. Those stimuli are found to include the
9154:
8904:
8902:
8900:
8898:
8896:
8894:
8892:
7658:Developmental and Comparative Immunology
7480:
7163:
6210:
5619:
3833:"ZFIN: Wild-Type Lines: Summary Listing"
3309:Orger MB, de Polavieja GG (2017-07-25).
3086:
3029:
2890:Behavior and morphogy of the zebrafish,
2854:"Coldwater fish and fisheries in Bhutan"
2851:
2845:
2636:
2584:
2374:List of freshwater aquarium fish species
2213:
2066:has been developed in zebrafish larvae.
2004:
1794:
1707:In January 2007, Chinese researchers at
1564:development processes in this species.)
1131:
1002:
986:
753:
583:
10006:Taxa named by Francis Buchanan-Hamilton
9339:The Zebrafish Genome Sequencing Project
9065:
8757:Bergen DJ, Kague E, Hammond CL (2019).
6769:
4930:
3511:
3126:
3124:
3122:
3120:
3095:
2810:
2744:
2269:
1940:. However it should also be noted that
1814:
762:The leopard danio, previously known as
329:, frequently sold under the trade name
9948:
9405:– using zebrafish for medical research
9341:at the Wellcome Trust Sanger Institute
9327:The European Zebrafish Resource Center
8752:
8750:
8150:
7015:
7013:
6914:from the original on November 12, 2020
5825:10.1146/annurev.genet.39.073003.105925
5771:10.1146/annurev.genet.37.110801.143752
5314:
5279:
5078:Bassett DI, Currie PD (October 2003).
4475:Lush ME, Piotrowski T (October 2014).
3662:Gerhard GS, Cheng KC (December 2002).
2961:"Zebrafish in the Natural Environment"
2953:
2711:
2664:
2662:
2660:
2658:
2196:
1518:of this species. By interfering via a
1450:In October 2001, researchers from the
1292:
1084:has yielded advances in the fields of
982:
9594:
9593:
9442:
8889:
8609:
7691:Renshaw SA, Trede NS (January 2012).
4887:
4881:
4228:
3806:
3731:
3524:from the original on January 15, 2021
2185:In programmes of research into acute
1567:
351:in scientific research, particularly
9933:4B89B955-01FC-4610-8399-F1C2559E94DB
8306:The Journal of Comparative Neurology
7601:Current Topics in Innate Immunity II
7178:10.1146/annurev-pathol-011110-130330
5559:from the original on October 5, 2016
5029:Xi Y, Noble S, Ekker M (June 2011).
4446:
4440:
4186:
4114:from the original on 6 December 2014
4064:Drug Discovery Today: Disease Models
3956:Current Environmental Health Reports
3117:
3035:
3011:"Brachydanio rerio (Hamilton, 1822)"
2732:from the original on October 3, 2016
2554:Drug Discovery Today: Disease Models
2524:from the original on 27 October 2023
1590:. In December 2005, a study of the
1445:
1402:
1073:is also one of the few fish species
792:
9956:IUCN Red List least concern species
9333:The China Zebrafish Resource Center
8747:
7010:
6974:Current Opinion in Chemical Biology
6666:10.1146/annurev-genom-090314-050048
6067:Cold Spring Harbor Laboratory Press
3330:10.1146/annurev-neuro-071714-033857
2655:
2416:IUCN Red List of Threatened Species
2175:congenital heart and kidney disease
2102:
1019:because it is unable to synthesize
999:, are widely studied by scientists.
572:signals by McHenry et al. 2009 and
337:" although it is both tropical and
13:
9263:from the original on June 16, 2013
9099:Your Guide to Freshwater Aquariums
9092:
9008:
7740:Meijer AH, Spaink HP (June 2011).
7527:. Fish For Science. Archived from
6266:GabaldĂłn T, Koonin EV (May 2013).
6053:Barolo S, Posakony JW (May 2002).
5940:Jeanna Bryner (February 6, 2008).
5022:
3809:Eyewitness Handbook: Aquarium Fish
2967:from the original on 28 March 2019
2895:(PhD thesis). University of Leeds.
2864:from the original on 28 March 2019
1315:
1030:is a common and useful scientific
809:, some of which are listed below.
686:
14:
10027:
9315:The Zebrafish Information Network
9277:
8257:Journal of Visualized Experiments
8102:Cronan MR, Tobin DM (July 2014).
7846:Journal of Visualized Experiments
7354:from the original on May 19, 2024
7210:from the original on May 19, 2024
6910:. University of Sheffield. 2011.
5952:from the original on May 19, 2024
5413:Journal of Visualized Experiments
4523:
4447:Wade, Nicholas (March 24, 2010).
4110:. Voice of America. 19 May 2010.
1955:
8953:
8844:
8801:
8696:
8652:
8616:Expert Opinion on Drug Discovery
8603:
8554:
8505:
8456:
8407:
8399:. August 3, 2007. Archived from
8383:
8342:
8293:
8244:
8193:
8144:
8095:
8054:
8013:
7978:
7929:
7878:
7833:
7782:
7733:
7684:
7649:
7592:
7543:
7517:
7474:
7417:
7366:
7336:
7279:
7222:
7192:
7157:
6961:
6926:
6900:
6851:
6794:
6384:10.1111/j.1752-4571.2012.00288.x
5200:10.1111/j.1365-294X.2011.05272.x
4536:from the original on 19 May 2024
3681:10.1046/j.1474-9728.2002.00012.x
3206:10.1111/j.1095-8649.2006.01206.x
3145:10.1111/j.1469-185X.2007.00030.x
3017:from the original on 7 June 2023
2888:Pritchard, V.L. (January 2001).
2482:10.1111/j.1365-294X.2011.05272.x
2180:
1195:, subsequently facilitating the
87:
9296:International Zebrafish Society
9054:from the original on 2024-02-24
8518:Disease Models & Mechanisms
8469:Disease Models & Mechanisms
8108:Disease Models & Mechanisms
7942:Disease Models & Mechanisms
7697:Disease Models & Mechanisms
6784:
6161:
6150:from the original on 2024-05-19
6103:
6005:
5964:
5933:
5882:
5847:
5616:(IGIB). Retrieved June 7, 2012.
5596:
5571:
5545:
5496:
5445:
5400:
5349:
5224:
5163:
5112:
5071:
4822:
4767:from the original on 2020-11-11
4749:
4738:from the original on 2018-02-05
4720:
4653:
4604:
4578:
4566:from the original on 2021-11-17
4562:via YouTube. January 31, 2011.
4548:
4517:
4381:
4322:
4273:
4222:
4180:
4100:
4051:
4000:
3943:
3884:
3843:from the original on 2023-05-19
3825:
3800:
3751:
3740:from the original on 2024-02-22
3725:
3714:from the original on 2018-03-12
3696:
3655:
3582:
3396:
3353:
3259:
3212:
3070:. June 14, 2013. Archived from
3068:United States Geological Survey
2761:Molecular Biology and Evolution
2241:grew a type of zebrafish adult
2030:
1964:-defective mutant with reduced
1719:
1621:
1409:Wellcome Trust Sanger Institute
1306:Single-nucleotide polymorphisms
1163:
779:China Zebrafish Resource Center
579:
428:
379:by researchers to produce many
7022:Nature Reviews. Drug Discovery
4629:10.1523/JNEUROSCI.1624-07.2007
3512:Dockser A (January 13, 2012).
2612:10.1523/JNEUROSCI.0758-12.2012
2506:
2444:
2078:, which is the integration of
2001:Drug discovery and development
1395:and promoter regulation using
1168:Zebrafish have the ability to
515:
1:
10001:Animal models in neuroscience
8709:BioMed Research International
5578:"Decoding the Genome Mystery"
5553:"Genome Reference Consortium"
3651:. University of Oregon Press.
3316:Annual Review of Neuroscience
3237:10.1016/s0531-5565(02)00088-8
3064:Nonindigenous Aquatic Species
2811:Parichy DM (September 2006).
2384:
2297:Bone physiology and pathology
2163:Alpha-1 adrenergic signalling
2040:) can suppress the growth of
1975:
1063:Zebrafish Information Network
799:Zebrafish Information Network
544:
371:. It is also notable for its
9368:Genome sequencing initiative
9174:10.1371/journal.pbio.0020148
8628:10.1517/17460441.2014.927435
8030:10.1007/978-1-4614-6111-1_13
7609:10.1007/978-1-4614-0106-3_15
7569:10.1182/blood-2007-06-095398
7443:10.1016/j.devcel.2023.09.011
6718:Macmillan Publishers Limited
6116:Cold Spring Harbor Protocols
5990:10.1016/j.devcel.2004.06.005
5375:10.1371/journal.pgen.1007000
5335:10.1016/0012-1606(85)90012-0
5300:10.1016/0012-1606(85)90010-7
4997:10.1371/journal.pbio.3000585
4956:10.1016/j.celrep.2019.03.090
4894:Current Pathobiology Reports
4415:10.1371/journal.pone.0023094
4248:10.1371/journal.pbio.0050281
3918:10.1371/journal.pone.0004361
3612:10.1016/j.envpol.2018.05.007
2989:Spence, R. (December 2006),
2013:on neurological development.
1775:
1433:In 2009, researchers at the
1255:after injury. In addition,
1075:to have been sent into space
727:(fluorescent colored fish).
7:
9981:Freshwater fish of Pakistan
8567:Journal of Medical Genetics
8368:10.1634/stemcells.2006-0724
8219:10.1016/j.ymeth.2013.06.002
8157:Seminars in Immunopathology
4617:The Journal of Neuroscience
4076:10.1016/j.ddmod.2007.09.002
3732:Gupta, Parth (2024-02-15).
2600:The Journal of Neuroscience
2567:10.1016/j.ddmod.2017.04.003
2361:
2352:
2322:
2287:Duchenne muscular dystrophy
2070:Computational data analysis
2048:Toxico- or pharmacokinetics
2018:than with more traditional
1920:The only exception are the
1428:Genome Reference Consortium
1426:, and is maintained by the
1347:(MO) are stable, synthetic
1287:
787:Chinese Academy of Sciences
745:yellow fluorescent proteins
490:
386:
10:
10032:
8865:10.1016/j.bone.2015.01.006
8810:Osteoporosis International
8763:Frontiers in Endocrinology
8610:Maves L (September 2014).
8080:10.1101/sqb.2013.78.023283
7758:10.2174/138945011795677809
7166:Annual Review of Pathology
6986:10.1016/j.cbpa.2014.10.025
6827:10.1038/s41598-018-35949-5
6186:10.1016/j.cell.2019.04.004
5133:10.1038/s41684-020-00683-x
4058:Major RJ, Poss KD (2007).
2687:10.1016/j.stem.2007.11.002
2331:
2150:transcriptional elongation
1948:between them than between
1674:Boston Children's Hospital
1049:and his colleagues at the
965:Hybrids between different
960:
730:
647:
355:, but also gene function,
333:(and thus often called a "
47:An adult female zebrafish
21:Zebrafish (disambiguation)
18:
9837:
9602:
9481:
9236:10.1038/nature.2012.11463
9157:"Small fish, big science"
9037:10.1163/1568539X-00003030
8979:10.3389/fcell.2020.573303
8822:10.1007/s00198-013-2441-3
8432:10.1007/s10038-006-0374-9
8420:Journal of Human Genetics
8169:10.1007/s00281-015-0522-4
7999:10.1016/j.tim.2014.04.014
7670:10.1016/j.dci.2007.11.011
7379:BMC Developmental Biology
6538:10.1007/s10126-006-5139-0
6425:Frontiers in Microbiology
6364:Evolutionary Applications
5808:Annual Review of Genetics
5754:Annual Review of Genetics
5257:10.1007/s10646-008-0267-0
5047:10.1007/s11910-011-0182-2
4906:10.1007/s40139-018-0158-x
4155:10.3390/molecules20046237
3976:10.1007/s40572-014-0029-5
3280:10.1007/s10071-016-1014-1
2996:, University of Leicester
2291:myotonic dystrophy type 1
2239:University College London
2107:
1466:) and 21 longer than the
1230:. Researchers frequently
225:
218:
199:
192:
84:Scientific classification
82:
60:
51:
46:
37:
30:
9996:Regenerative biomedicine
9976:Freshwater fish of India
9070:Freshwater Aquarium Fish
8928:10.3389/fcell.2018.00091
8776:10.3389/fendo.2019.00006
8151:Meijer AH (March 2016).
6443:10.3389/fmicb.2014.00207
6317:Nature Reviews. Genetics
6272:Nature Reviews. Genetics
5090:(Spec No 2): R265–R270.
5084:Human Molecular Genetics
4888:Kizil C (January 2018).
4560:British Heart Foundation
4229:Jones R (October 2007).
3776:10.1038/sj.embor.7400757
3421:10.1177/0023677219869037
3225:Experimental Gerontology
3099:; Pauly, Daniel (eds.).
2347:environmental toxicology
2341:Environmental toxicology
2210:Repairing retinal damage
2171:blood vessel development
2126:hepatocellular carcinoma
1724:In 2015, researchers at
1672:In 2008, researchers at
1668:Transparent adult bodies
1371:after the divergence of
1270:Fibroblast growth factor
1245:fibroblast growth factor
1213:British Heart Foundation
1096:, reproductive studies,
433:
375:abilities, and has been
369:pre-clinical development
310:belonging to the minnow
9431:genome assembly in the
9155:Bradbury J (May 2004).
8061:Ramakrishnan L (2013).
7392:10.1186/1471-213X-11-21
6762:. NIHMSID: NIHMS368312.
6059:Genes & Development
5911:10.1126/science.1116238
5868:10.1242/dev.126.17.3757
4856:10.1073/pnas.1318692111
4687:10.1073/pnas.0904132106
4356:10.1073/pnas.0806015105
4189:"The Zebrafish Exposed"
3592:Environmental Pollution
3374:10.1002/jmor.1052180209
3186:Journal of Fish Biology
2963:. University of Otago.
2518:www.thefishdoctor.co.uk
2405:Vishwanath, W. (2010).
2312:osteogenesis imperfecta
1983:reactive oxygen species
1962:glucocorticoid receptor
1927:Ctenopharyngodon idella
1924:(including Grass Carp,
1809:anthropogenic pollution
1343:technology. Morpholino
1197:Notch signaling pathway
995:, shown here mediating
739:zebrafish that express
421:, as demonstrated by a
9961:Fish described in 1822
9200:Westerfield M (2007).
9132:10.1089/zeb.2005.2.147
7987:Trends in Microbiology
7795:Advances in Hematology
7495:10.1681/ASN.2004090754
6864:Toxicological Sciences
6642:McCammon, Jasmine M.;
6589:Reviews in Aquaculture
6128:10.1101/pdb.prot086850
6122:(10): pdb.prot086850.
6018:Developmental Dynamics
5509:Nucleic Acids Research
4794:Developmental Dynamics
4481:Developmental Dynamics
3641:Westerfield M (2007).
3554:Toxicological Sciences
2830:10.1038/sj.hdy.6800867
2219:
2156:Cardiovascular disease
2014:
1896:Gasterosteus aculeatus
1499:Developmental genetics
1452:University of Oklahoma
1351:that contain the same
1330:reduce gene expression
1110:environmental sciences
1024:
1000:
766:, is a spotted colour
759:
708:Pseudoloma neurophilia
642:endocannabinoid system
617:a convenient research
589:
8662:Journal of Morphology
8579:10.1136/jmg.38.10.649
7891:Cellular Microbiology
7084:10.1089/zeb.2016.1313
6876:10.1093/toxsci/kfy250
6235:10.1101/gr.181008.114
5323:Developmental Biology
5288:Developmental Biology
3872:on September 29, 2015
3567:10.1093/toxsci/kfi110
3470:10.1534/g3.111.000190
3362:Journal of Morphology
3113:. March 2019 version.
2931:10.1089/zeb.2006.9997
2773:10.1093/molbev/msu325
2423:: e.T166487A6219667.
2217:
2008:
1952:and any farmed fish.
1801:inbreeding depression
1795:Inbreeding depression
1484:origin of replication
1417:Zebrafish Genome Page
1236:histone demethylation
1146:embryonic development
1132:Model characteristics
1118:regenerative medicine
1086:developmental biology
1006:
997:background adaptation
990:
941:Tupfel long fin nacre
757:
664:, insects and insect
587:
353:developmental biology
9221:Guttridge N (2012).
9031:(10/12): 1019–1036.
8722:10.1155/2019/1253710
7746:Current Drug Targets
7436:(22): 2460–2476.e7.
6705:Molecular Psychiatry
6502:Marine Biotechnology
6180:(7): 1903–1914.e14.
6071:The Genetics Society
4524:Teske, Christopher.
4026:10.3390/ijms17111941
3866:University of Oregon
3708:Encyclopedia of Life
2728:. January 31, 2013.
2520:. 16 November 2013.
2275:Muscular dystrophies
2270:Muscular dystrophies
2251:macular degeneration
2076:systems pharmacology
1966:exploratory behavior
1914:Xiphophorus hellerii
1815:Aquaculture research
1690:natural killer cells
1588:Waardenburg Syndrome
1542:transcription factor
1122:muscular dystrophies
1051:University of Oregon
638:diisononyl phthalate
555:conscious experience
479:Zebrafish have been
395:member of the genus
285:Perilamopus striatus
19:For other uses, see
9542:Medicago truncatula
9433:UCSC Genome Browser
9105:on December 7, 2016
9066:Lambert DJ (1997).
7808:10.1155/2012/159807
7312:10.1038/nature09882
7304:2011Natur.471..518W
7255:10.1038/nature09806
7247:2011Natur.471..513C
6819:2019NatSR...9..145M
6696: •
6640: •
6530:2006MarBt...8..329D
6376:2013EvApp...6..279B
5903:2005Sci...310.1782L
5897:(5755): 1782–1786.
5655:10.1038/nature12111
5647:2013Natur.496..498H
5471:10.1155/2012/350352
5464:. Hindawi: 350352.
5249:2009Ecotx..18..144C
5192:2011MolEc..20.4259W
4949:(4): 1307–1318.e3.
4847:2014PNAS..111E1393S
4841:(14): E1393–E1401.
4678:2009PNAS..10619889S
4672:(47): 19889–19894.
4406:2011PLoSO...623094R
4347:2008PNAS..10512485J
4341:(34): 12485–12490.
4298:2012Natur.491..333P
4205:10.1511/2006.61.446
3968:2014CEHR....1..341B
3909:2009PLoSO...4.4361X
3604:2018EPoll.241....1F
3518:Wall Street Journal
3198:2006JFBio..69.1435S
2474:2011MolEc..20.4259W
2197:Infectious diseases
1987:damage to their DNA
1855:Protacanthopterygii
1764:was found in other
1762:secondary structure
1633:transposon system.
1293:Background genetics
1220:photoreceptor cells
1126:evolutionary theory
1044:molecular biologist
983:Scientific research
702:or velvet disease,
656:, primarily eating
442:, ranging from the
391:The zebrafish is a
236:Brachydanio frankei
54:Conservation status
9991:Stem cell research
9971:Fish of Bangladesh
9421:Breeding Zebrafish
9414:2021-01-21 at the
9403:FishforScience.com
9373:2020-10-14 at the
9360:2020-10-11 at the
9307:2019-02-02 at the
9289:2018-05-19 at the
8530:10.1242/dmm.012427
8481:10.1242/dmm.004150
8120:10.1242/dmm.016089
7954:10.1242/dmm.015594
7709:10.1242/dmm.007138
7531:on January 9, 2013
7430:Developmental Cell
7350:. March 24, 2011.
7206:. March 23, 2011.
7133:10.1002/psp4.12297
6947:10.1002/bdrb.20223
6908:"Fish for Science"
6807:Scientific Reports
6726:10.1038/mp.2012.64
6080:10.1101/gad.976502
6031:10.1002/dvdy.20157
5977:Developmental Cell
5608:2018-07-19 at the
5583:2009-07-15 at the
5521:10.1093/nar/gkg763
5097:10.1093/hmg/ddg279
4807:10.1002/dvdy.23973
4493:10.1002/dvdy.24167
4453:The New York Times
4193:American Scientist
3811:. Harper Collins.
3409:Laboratory Animals
3231:(8–9): 1055–1068.
2757:, a "model genus""
2368:Japanese rice fish
2220:
2015:
1568:Pigmentation genes
1377:lobe-finned fishes
1302:replication crisis
1278:muscular dystrophy
1247:, to ensure their
1047:George Streisinger
1025:
1001:
760:
590:
425:of close species.
409:relationship with
9943:
9942:
9809:Open Tree of Life
9596:Taxon identifiers
9587:
9586:
9259:. June 14, 2013.
9085:978-0-7858-0867-1
8674:10.1002/jmor.1065
8318:10.1002/cne.22447
8312:(20): 4182–4195.
8039:978-1-4614-6110-4
7904:10.1111/cmi.12236
7298:(7339): 518–522.
7241:(7339): 513–517.
6606:10.1111/raq.12041
5862:(17): 3757–3767.
5711:10.1101/gr.156801
5705:(11): 1958–1967.
5641:(7446): 498–503.
5515:(19): 5676–5684.
5186:(20): 4259–4276.
5180:Molecular Ecology
4623:(26): 7028–7040.
4487:(10): 1187–1202.
3818:978-0-7322-5012-6
3074:on August 4, 2009
3013:. SeriouslyFish.
2852:Petr, T. (1999).
2606:(22): 7477–7492.
2468:(20): 4259–4276.
2462:Molecular Ecology
2314:. The (elasmoid)
2122:pancreatic cancer
1908:Takifugu rubripes
1884:Carassius auratus
1616:roy orbison (roy)
1464:Carassius auratus
1460:mitochondrial DNA
1446:Mitochondrial DNA
1403:Genome sequencing
1373:ray-finned fishes
1259:of the posterior
1189:endothelial cells
976:D. nigrofasciatus
793:Wild-type strains
631:Circadian rhythms
456:Brahmaputra River
448:Arunachal Pradesh
423:phylogenetic tree
294:
293:
288:
281:
274:
267:
260:
253:
250:Cyprinus chapalio
246:
243:Brachydanio rerio
239:
232:
77:
10023:
9936:
9935:
9923:
9922:
9910:
9909:
9897:
9896:
9884:
9883:
9871:
9870:
9858:
9857:
9856:
9830:
9829:
9817:
9816:
9804:
9803:
9791:
9790:
9781:
9780:
9768:
9767:
9755:
9754:
9742:
9741:
9729:
9728:
9716:
9715:
9703:
9702:
9690:
9689:
9677:
9676:
9664:
9663:
9651:
9650:
9638:
9637:
9636:
9623:
9622:
9621:
9591:
9590:
9463:
9456:
9449:
9440:
9439:
9394:Zebrafish genome
9272:
9270:
9268:
9248:
9238:
9217:
9196:
9186:
9176:
9151:
9114:
9112:
9110:
9101:. Archived from
9089:
9073:
9062:
9060:
9059:
9053:
9022:
9002:
9001:
8991:
8981:
8957:
8951:
8950:
8940:
8930:
8906:
8887:
8886:
8876:
8848:
8842:
8841:
8805:
8799:
8798:
8788:
8778:
8754:
8745:
8744:
8734:
8724:
8700:
8694:
8693:
8656:
8650:
8649:
8639:
8622:(9): 1033–1045.
8607:
8601:
8600:
8590:
8558:
8552:
8551:
8541:
8509:
8503:
8502:
8492:
8460:
8454:
8453:
8443:
8411:
8405:
8404:
8387:
8381:
8380:
8370:
8361:(8): 2033–2043.
8346:
8340:
8339:
8329:
8297:
8291:
8290:
8280:
8248:
8242:
8241:
8231:
8221:
8197:
8191:
8190:
8180:
8148:
8142:
8141:
8131:
8099:
8093:
8092:
8082:
8058:
8052:
8051:
8017:
8011:
8010:
7982:
7976:
7975:
7965:
7933:
7927:
7926:
7916:
7906:
7882:
7876:
7875:
7865:
7837:
7831:
7830:
7820:
7810:
7786:
7780:
7779:
7769:
7752:(7): 1000–1017.
7737:
7731:
7730:
7720:
7688:
7682:
7681:
7653:
7647:
7646:
7596:
7590:
7589:
7571:
7547:
7541:
7540:
7538:
7536:
7521:
7515:
7514:
7478:
7472:
7471:
7445:
7421:
7415:
7414:
7404:
7394:
7370:
7364:
7363:
7361:
7359:
7340:
7334:
7333:
7323:
7283:
7277:
7276:
7266:
7226:
7220:
7219:
7217:
7215:
7196:
7190:
7189:
7161:
7155:
7154:
7144:
7112:
7106:
7105:
7095:
7063:
7054:
7053:
7017:
7008:
7007:
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6965:
6959:
6958:
6930:
6924:
6923:
6921:
6919:
6904:
6898:
6897:
6887:
6855:
6849:
6848:
6838:
6798:
6792:
6788:
6782:
6778:
6767:
6763:
6745:
6714:Nature Portfolio
6693:
6635:
6626:
6625:
6579:
6566:
6565:
6497:
6482:
6481:
6463:
6445:
6415:
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6405:
6395:
6355:
6349:
6348:
6312:
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6305:
6295:
6263:
6257:
6256:
6246:
6214:
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6207:
6197:
6165:
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6158:
6156:
6155:
6107:
6101:
6100:
6082:
6050:
6044:
6043:
6033:
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6003:
6002:
5992:
5968:
5962:
5961:
5959:
5957:
5937:
5931:
5930:
5886:
5880:
5879:
5851:
5845:
5844:
5802:
5791:
5790:
5748:
5733:
5732:
5722:
5686:
5677:
5676:
5666:
5626:
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5568:
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5564:
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5542:
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5449:
5443:
5442:
5432:
5404:
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5397:
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5377:
5368:(10): e1007000.
5353:
5347:
5346:
5318:
5312:
5311:
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5277:
5276:
5228:
5222:
5221:
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4809:
4785:
4776:
4775:
4773:
4772:
4753:
4747:
4746:
4744:
4743:
4724:
4718:
4717:
4707:
4689:
4657:
4651:
4650:
4640:
4608:
4602:
4601:
4599:
4597:
4592:on 10 March 2012
4582:
4576:
4575:
4573:
4571:
4552:
4546:
4545:
4543:
4541:
4530:Researchgate.com
4521:
4515:
4514:
4504:
4472:
4463:
4462:
4460:
4455:. Archived from
4444:
4438:
4437:
4427:
4417:
4385:
4379:
4378:
4368:
4358:
4326:
4320:
4319:
4309:
4277:
4271:
4270:
4260:
4250:
4226:
4220:
4219:
4217:
4216:
4207:. Archived from
4184:
4178:
4177:
4167:
4157:
4148:(4): 6237–6253.
4133:
4124:
4123:
4121:
4119:
4104:
4098:
4097:
4087:
4055:
4049:
4048:
4038:
4028:
4004:
3998:
3997:
3987:
3947:
3941:
3940:
3930:
3920:
3888:
3882:
3881:
3879:
3877:
3868:. Archived from
3858:
3852:
3851:
3849:
3848:
3829:
3823:
3822:
3807:Mills D (1993).
3804:
3798:
3797:
3787:
3755:
3749:
3748:
3746:
3745:
3729:
3723:
3722:
3720:
3719:
3700:
3694:
3693:
3683:
3659:
3653:
3652:
3638:
3632:
3631:
3586:
3580:
3579:
3569:
3545:
3534:
3533:
3531:
3529:
3509:
3500:
3499:
3481:
3449:
3443:
3442:
3432:
3400:
3394:
3393:
3357:
3351:
3350:
3332:
3306:
3300:
3299:
3274:(6): 1071–1079.
3268:Animal Cognition
3263:
3257:
3256:
3216:
3210:
3209:
3192:(5): 1435–1448.
3181:
3175:
3174:
3156:
3128:
3115:
3114:
3093:
3084:
3083:
3081:
3079:
3056:
3050:
3049:
3036:Fang F (1998). "
3033:
3027:
3026:
3024:
3022:
3007:
2998:
2997:
2986:
2977:
2976:
2974:
2972:
2957:
2951:
2950:
2914:
2897:
2896:
2885:
2874:
2873:
2871:
2869:
2849:
2843:
2842:
2832:
2808:
2795:
2794:
2784:
2748:
2742:
2741:
2739:
2737:
2718:
2709:
2708:
2698:
2666:
2653:
2643:
2634:
2633:
2623:
2591:
2582:
2581:
2579:
2569:
2545:
2534:
2533:
2531:
2529:
2510:
2504:
2503:
2493:
2448:
2442:
2441:
2439:
2437:
2432:
2402:
2103:Medical research
1946:genetic distance
1930:) and Milkfish (
1893:), Stickleback (
1840:
1726:Brown University
1709:Fudan University
1383:reliably due to
1345:oligonucleotides
1328:technique is to
1326:reverse genetics
1172:their heart and
1038:development and
592:The approximate
536:in front of the
412:Danio aesculapii
401:, of the family
367:, in particular
365:drug development
287:
280:
273:
266:
259:
252:
245:
238:
231:
205:
92:
91:
71:
66:
65:
42:
28:
27:
10031:
10030:
10026:
10025:
10024:
10022:
10021:
10020:
9946:
9945:
9944:
9939:
9931:
9926:
9918:
9913:
9905:
9900:
9892:
9887:
9879:
9874:
9866:
9861:
9852:
9851:
9846:
9833:
9825:
9820:
9812:
9807:
9799:
9794:
9786:
9784:
9776:
9771:
9763:
9758:
9750:
9745:
9737:
9732:
9724:
9719:
9711:
9706:
9698:
9693:
9685:
9680:
9672:
9667:
9659:
9654:
9646:
9641:
9632:
9631:
9626:
9617:
9616:
9611:
9598:
9588:
9583:
9477:
9471:model organisms
9467:
9416:Wayback Machine
9375:Wayback Machine
9362:Wayback Machine
9309:Wayback Machine
9291:Wayback Machine
9280:
9275:
9266:
9264:
9251:
9108:
9106:
9086:
9057:
9055:
9051:
9020:
9011:
9009:Further reading
9006:
9005:
8958:
8954:
8907:
8890:
8849:
8845:
8806:
8802:
8755:
8748:
8701:
8697:
8657:
8653:
8608:
8604:
8573:(10): 649–657.
8559:
8555:
8510:
8506:
8461:
8457:
8412:
8408:
8389:
8388:
8384:
8347:
8343:
8298:
8294:
8249:
8245:
8198:
8194:
8149:
8145:
8100:
8096:
8059:
8055:
8040:
8018:
8014:
7983:
7979:
7934:
7930:
7883:
7879:
7838:
7834:
7787:
7783:
7738:
7734:
7689:
7685:
7654:
7650:
7627:
7597:
7593:
7548:
7544:
7534:
7532:
7523:
7522:
7518:
7479:
7475:
7422:
7418:
7371:
7367:
7357:
7355:
7342:
7341:
7337:
7284:
7280:
7227:
7223:
7213:
7211:
7198:
7197:
7193:
7162:
7158:
7113:
7109:
7064:
7057:
7034:10.1038/nrd4627
7028:(10): 721–731.
7018:
7011:
6966:
6962:
6931:
6927:
6917:
6915:
6906:
6905:
6901:
6856:
6852:
6799:
6795:
6789:
6785:
6779:
6770:
6766:
6636:
6629:
6580:
6569:
6498:
6485:
6416:
6409:
6356:
6352:
6329:10.1038/nrg2664
6323:(11): 783–796.
6313:
6309:
6284:10.1038/nrg3456
6264:
6260:
6223:Genome Research
6215:
6211:
6166:
6162:
6153:
6151:
6108:
6104:
6051:
6047:
6010:
6006:
5969:
5965:
5955:
5953:
5946:livescience.com
5938:
5934:
5887:
5883:
5852:
5848:
5803:
5794:
5749:
5736:
5699:Genome Research
5687:
5680:
5627:
5620:
5610:Wayback Machine
5601:
5597:
5585:Wayback Machine
5576:
5572:
5562:
5560:
5551:
5550:
5546:
5501:
5497:
5450:
5446:
5405:
5401:
5354:
5350:
5319:
5315:
5284:
5280:
5229:
5225:
5168:
5164:
5117:
5113:
5076:
5072:
5027:
5023:
4990:(1): e3000585.
4976:
4972:
4935:
4931:
4886:
4882:
4827:
4823:
4786:
4779:
4770:
4768:
4755:
4754:
4750:
4741:
4739:
4726:
4725:
4721:
4658:
4654:
4609:
4605:
4595:
4593:
4584:
4583:
4579:
4569:
4567:
4554:
4553:
4549:
4539:
4537:
4522:
4518:
4473:
4466:
4445:
4441:
4386:
4382:
4327:
4323:
4307:10.1038/491333a
4278:
4274:
4227:
4223:
4214:
4212:
4187:Dahm R (2006).
4185:
4181:
4134:
4127:
4117:
4115:
4106:
4105:
4101:
4056:
4052:
4005:
4001:
3948:
3944:
3889:
3885:
3875:
3873:
3860:
3859:
3855:
3846:
3844:
3831:
3830:
3826:
3819:
3805:
3801:
3756:
3752:
3743:
3741:
3730:
3726:
3717:
3715:
3702:
3701:
3697:
3660:
3656:
3639:
3635:
3587:
3583:
3546:
3537:
3527:
3525:
3510:
3503:
3450:
3446:
3401:
3397:
3358:
3354:
3307:
3303:
3264:
3260:
3217:
3213:
3182:
3178:
3129:
3118:
3094:
3087:
3077:
3075:
3058:
3057:
3053:
3034:
3030:
3020:
3018:
3009:
3008:
3001:
2987:
2980:
2970:
2968:
2959:
2958:
2954:
2915:
2900:
2886:
2877:
2867:
2865:
2850:
2846:
2809:
2798:
2749:
2745:
2735:
2733:
2726:Popular Science
2720:
2719:
2712:
2667:
2656:
2644:
2637:
2592:
2585:
2546:
2537:
2527:
2525:
2512:
2511:
2507:
2449:
2445:
2435:
2433:
2403:
2392:
2387:
2364:
2355:
2343:
2334:
2325:
2299:
2272:
2212:
2199:
2183:
2158:
2110:
2105:
2088:clinical trials
2084:pharmacometrics
2080:systems biology
2072:
2059:pharmacodynamic
2055:pharmacokinetic
2050:
2042:prostate cancer
2033:
2003:
1985:that may cause
1978:
1958:
1905:), Pufferfish (
1902:Rutilus rutilus
1890:Oryzias latipes
1838:
1817:
1797:
1778:
1722:
1670:
1624:
1570:
1544:– are vital to
1534:and its target
1501:
1472:Cyprinus carpio
1448:
1405:
1385:complementation
1318:
1316:Gene expression
1295:
1290:
1211:. In 2011, the
1166:
1142:fully sequenced
1134:
1059:genetic screens
1034:for studies of
985:
963:
958:
935:Tupfel long fin
795:
758:A leopard danio
733:
689:
687:In the aquarium
650:
594:generation time
582:
551:episodic memory
547:
534:genital papilla
524:. Its shape is
518:
493:
436:
431:
389:
308:freshwater fish
214:
207:
201:
188:
86:
78:
67:
63:
56:
24:
17:
16:Species of fish
12:
11:
5:
10029:
10019:
10018:
10016:Fish of Bhutan
10013:
10008:
10003:
9998:
9993:
9988:
9983:
9978:
9973:
9968:
9963:
9958:
9941:
9940:
9938:
9937:
9924:
9911:
9898:
9885:
9872:
9859:
9843:
9841:
9839:Cyprinus rerio
9835:
9834:
9832:
9831:
9818:
9805:
9792:
9782:
9769:
9756:
9743:
9730:
9717:
9704:
9691:
9678:
9665:
9652:
9639:
9624:
9608:
9606:
9600:
9599:
9585:
9584:
9582:
9581:
9576:
9571:
9566:
9559:
9552:
9545:
9538:
9531:
9526:
9519:
9514:
9509:
9502:
9495:
9488:
9482:
9479:
9478:
9466:
9465:
9458:
9451:
9443:
9437:
9436:
9423:
9418:
9406:
9400:
9391:
9386:
9385:at Danios.info
9378:
9365:
9352:
9342:
9336:
9330:
9324:
9318:
9312:
9311:(EuFishBioMed)
9299:
9293:
9279:
9278:External links
9276:
9274:
9273:
9249:
9218:
9197:
9152:
9126:(3): 147–156.
9115:
9090:
9084:
9063:
9012:
9010:
9007:
9004:
9003:
8952:
8888:
8843:
8816:(2): 567–578.
8800:
8746:
8695:
8668:(3): 197–207.
8651:
8602:
8553:
8524:(1): 143–155.
8504:
8475:(3): 381–392.
8455:
8426:(5): 397–406.
8406:
8403:on 2012-09-10.
8396:The China Post
8382:
8341:
8292:
8263:(88): e51649.
8243:
8212:(3): 246–254.
8192:
8163:(2): 261–273.
8143:
8114:(7): 777–784.
8094:
8053:
8038:
8012:
7993:(9): 490–497.
7977:
7948:(7): 785–797.
7928:
7877:
7832:
7781:
7732:
7683:
7664:(7): 745–757.
7648:
7625:
7591:
7562:(1): 132–141.
7542:
7516:
7489:(2): 299–304.
7473:
7416:
7365:
7335:
7278:
7221:
7191:
7156:
7127:(5): 285–287.
7107:
7078:(6): 504–510.
7055:
7009:
6960:
6925:
6899:
6870:(2): 438–449.
6850:
6793:
6783:
6768:
6765:
6764:
6694:
6658:Annual Reviews
6637:
6627:
6567:
6483:
6407:
6370:(2): 279–289.
6350:
6307:
6278:(5): 360–366.
6258:
6209:
6160:
6102:
6045:
6024:(2): 449–459.
6004:
5983:(1): 133–144.
5963:
5932:
5881:
5846:
5817:Annual Reviews
5792:
5763:Annual Reviews
5734:
5678:
5618:
5595:
5590:Indian Express
5570:
5544:
5495:
5444:
5399:
5348:
5313:
5278:
5243:(1): 144–150.
5223:
5162:
5111:
5070:
5041:(3): 274–282.
5021:
4970:
4929:
4880:
4821:
4800:(7): 832–846.
4777:
4748:
4719:
4652:
4603:
4577:
4547:
4516:
4464:
4461:on 2022-01-01.
4439:
4380:
4321:
4272:
4221:
4179:
4125:
4099:
4070:(4): 219–225.
4050:
3999:
3962:(4): 341–352.
3942:
3883:
3853:
3824:
3817:
3799:
3770:(9): 893–897.
3750:
3724:
3695:
3674:(2): 104–111.
3654:
3633:
3581:
3535:
3501:
3444:
3415:(3): 213–224.
3395:
3368:(2): 203–224.
3352:
3323:(1): 125–147.
3301:
3258:
3211:
3176:
3116:
3097:Froese, Rainer
3085:
3051:
3028:
2999:
2978:
2952:
2898:
2875:
2844:
2823:(3): 200–210.
2796:
2767:(3): 635–652.
2743:
2710:
2681:(2): 183–189.
2675:Cell Stem Cell
2654:
2635:
2583:
2535:
2505:
2443:
2389:
2388:
2386:
2383:
2382:
2381:
2376:
2371:
2363:
2360:
2354:
2351:
2342:
2339:
2333:
2330:
2324:
2321:
2298:
2295:
2271:
2268:
2211:
2208:
2198:
2195:
2182:
2179:
2167:blood clotting
2157:
2154:
2134:Histologically
2109:
2106:
2104:
2101:
2071:
2068:
2049:
2046:
2032:
2029:
2002:
1999:
1977:
1974:
1957:
1956:Neurochemistry
1954:
1911:), Swordtail (
1816:
1813:
1796:
1793:
1777:
1774:
1721:
1718:
1669:
1666:
1647:Catenin beta-1
1623:
1620:
1569:
1566:
1522:nonfunctional
1500:
1497:
1447:
1444:
1404:
1401:
1349:macromolecules
1317:
1314:
1310:microsatellite
1298:Inbred strains
1294:
1291:
1289:
1286:
1253:glial scarring
1165:
1162:
1133:
1130:
1080:Research with
1032:model organism
993:chromatophores
984:
981:
962:
959:
957:
956:
950:
944:
938:
932:
926:
920:
914:
908:
902:
896:
890:
884:
878:
872:
866:
860:
854:
848:
842:
836:
830:
824:
818:
811:
794:
791:
735:In late 2003,
732:
729:
688:
685:
652:Zebrafish are
649:
646:
581:
578:
574:visual signals
562:Mauthner cells
546:
543:
517:
514:
492:
489:
435:
432:
430:
427:
388:
385:
349:model organism
292:
291:
290:
289:
282:
275:
271:Danio lineatus
268:
261:
257:Cyprinus rerio
254:
247:
240:
233:
229:Barilius rerio
223:
222:
216:
215:
208:
197:
196:
190:
189:
182:
180:
176:
175:
168:
164:
163:
158:
154:
153:
148:
144:
143:
138:
134:
133:
131:Actinopterygii
128:
124:
123:
118:
114:
113:
108:
104:
103:
98:
94:
93:
80:
79:
61:
58:
57:
52:
49:
48:
44:
43:
35:
34:
15:
9:
6:
4:
3:
2:
10028:
10017:
10014:
10012:
10011:Fish of Nepal
10009:
10007:
10004:
10002:
9999:
9997:
9994:
9992:
9989:
9987:
9986:Animal models
9984:
9982:
9979:
9977:
9974:
9972:
9969:
9967:
9964:
9962:
9959:
9957:
9954:
9953:
9951:
9934:
9929:
9925:
9921:
9916:
9912:
9908:
9903:
9899:
9895:
9890:
9886:
9882:
9877:
9873:
9869:
9864:
9860:
9855:
9849:
9845:
9844:
9842:
9840:
9836:
9828:
9823:
9819:
9815:
9810:
9806:
9802:
9797:
9793:
9789:
9783:
9779:
9774:
9770:
9766:
9761:
9757:
9753:
9748:
9744:
9740:
9735:
9731:
9727:
9722:
9718:
9714:
9709:
9705:
9701:
9696:
9692:
9688:
9683:
9679:
9675:
9670:
9666:
9662:
9657:
9653:
9649:
9644:
9640:
9635:
9629:
9625:
9620:
9614:
9610:
9609:
9607:
9605:
9601:
9597:
9592:
9580:
9577:
9575:
9572:
9570:
9567:
9565:
9564:
9560:
9558:
9557:
9553:
9551:
9550:
9546:
9544:
9543:
9539:
9537:
9536:
9532:
9530:
9527:
9525:
9524:
9520:
9518:
9517:Fission yeast
9515:
9513:
9512:Budding yeast
9510:
9508:
9507:
9503:
9501:
9500:
9499:Chlamydomonas
9496:
9494:
9493:
9489:
9487:
9484:
9483:
9480:
9476:
9472:
9464:
9459:
9457:
9452:
9450:
9445:
9444:
9441:
9434:
9430:
9429:
9424:
9422:
9419:
9417:
9413:
9410:
9409:FishForPharma
9407:
9404:
9401:
9399:
9395:
9392:
9390:
9387:
9384:
9383:
9379:
9376:
9372:
9369:
9366:
9363:
9359:
9356:
9353:
9350:
9346:
9343:
9340:
9337:
9334:
9331:
9328:
9325:
9322:
9319:
9316:
9313:
9310:
9306:
9303:
9300:
9297:
9294:
9292:
9288:
9285:
9282:
9281:
9262:
9258:
9254:
9250:
9246:
9242:
9237:
9232:
9228:
9224:
9219:
9215:
9211:
9207:
9203:
9198:
9194:
9190:
9185:
9180:
9175:
9170:
9166:
9162:
9158:
9153:
9149:
9145:
9141:
9137:
9133:
9129:
9125:
9121:
9116:
9104:
9100:
9096:
9095:"Zebra Danio"
9091:
9087:
9081:
9077:
9072:
9071:
9064:
9050:
9046:
9042:
9038:
9034:
9030:
9026:
9019:
9014:
9013:
8999:
8995:
8990:
8985:
8980:
8975:
8971:
8967:
8963:
8956:
8948:
8944:
8939:
8934:
8929:
8924:
8920:
8916:
8912:
8905:
8903:
8901:
8899:
8897:
8895:
8893:
8884:
8880:
8875:
8870:
8866:
8862:
8858:
8854:
8847:
8839:
8835:
8831:
8827:
8823:
8819:
8815:
8811:
8804:
8796:
8792:
8787:
8782:
8777:
8772:
8768:
8764:
8760:
8753:
8751:
8742:
8738:
8733:
8728:
8723:
8718:
8714:
8710:
8706:
8699:
8691:
8687:
8683:
8679:
8675:
8671:
8667:
8663:
8655:
8647:
8643:
8638:
8633:
8629:
8625:
8621:
8617:
8613:
8606:
8598:
8594:
8589:
8584:
8580:
8576:
8572:
8568:
8564:
8557:
8549:
8545:
8540:
8535:
8531:
8527:
8523:
8519:
8515:
8508:
8500:
8496:
8491:
8486:
8482:
8478:
8474:
8470:
8466:
8459:
8451:
8447:
8442:
8437:
8433:
8429:
8425:
8421:
8417:
8410:
8402:
8398:
8397:
8392:
8386:
8378:
8374:
8369:
8364:
8360:
8356:
8352:
8345:
8337:
8333:
8328:
8323:
8319:
8315:
8311:
8307:
8303:
8296:
8288:
8284:
8279:
8274:
8270:
8269:10.3791/51649
8266:
8262:
8258:
8254:
8247:
8239:
8235:
8230:
8229:10044/1/53161
8225:
8220:
8215:
8211:
8207:
8203:
8196:
8188:
8184:
8179:
8174:
8170:
8166:
8162:
8158:
8154:
8147:
8139:
8135:
8130:
8125:
8121:
8117:
8113:
8109:
8105:
8098:
8090:
8086:
8081:
8076:
8072:
8068:
8064:
8057:
8049:
8045:
8041:
8035:
8031:
8027:
8023:
8016:
8008:
8004:
8000:
7996:
7992:
7988:
7981:
7973:
7969:
7964:
7959:
7955:
7951:
7947:
7943:
7939:
7932:
7924:
7920:
7915:
7910:
7905:
7900:
7896:
7892:
7888:
7881:
7873:
7869:
7864:
7859:
7855:
7851:
7847:
7843:
7836:
7828:
7824:
7819:
7814:
7809:
7804:
7800:
7796:
7792:
7785:
7777:
7773:
7768:
7763:
7759:
7755:
7751:
7747:
7743:
7736:
7728:
7724:
7719:
7714:
7710:
7706:
7702:
7698:
7694:
7687:
7679:
7675:
7671:
7667:
7663:
7659:
7652:
7644:
7640:
7636:
7632:
7628:
7626:9781461401056
7622:
7618:
7614:
7610:
7606:
7602:
7595:
7587:
7583:
7579:
7575:
7570:
7565:
7561:
7557:
7553:
7546:
7530:
7526:
7520:
7512:
7508:
7504:
7500:
7496:
7492:
7488:
7484:
7477:
7469:
7465:
7461:
7457:
7453:
7449:
7444:
7439:
7435:
7431:
7427:
7420:
7412:
7408:
7403:
7398:
7393:
7388:
7384:
7380:
7376:
7369:
7353:
7349:
7345:
7339:
7331:
7327:
7322:
7317:
7313:
7309:
7305:
7301:
7297:
7293:
7289:
7282:
7274:
7270:
7265:
7260:
7256:
7252:
7248:
7244:
7240:
7236:
7232:
7225:
7209:
7205:
7204:Science Daily
7201:
7195:
7187:
7183:
7179:
7175:
7171:
7167:
7160:
7152:
7148:
7143:
7138:
7134:
7130:
7126:
7122:
7118:
7111:
7103:
7099:
7094:
7089:
7085:
7081:
7077:
7073:
7069:
7062:
7060:
7051:
7047:
7043:
7039:
7035:
7031:
7027:
7023:
7016:
7014:
7005:
7001:
6996:
6991:
6987:
6983:
6979:
6975:
6971:
6964:
6956:
6952:
6948:
6944:
6940:
6936:
6929:
6913:
6909:
6903:
6895:
6891:
6886:
6881:
6877:
6873:
6869:
6865:
6861:
6854:
6846:
6842:
6837:
6832:
6828:
6824:
6820:
6816:
6812:
6808:
6804:
6797:
6787:
6777:
6775:
6773:
6761:
6757:
6753:
6749:
6744:
6739:
6735:
6731:
6727:
6723:
6719:
6715:
6711:
6707:
6706:
6701:
6695:
6691:
6687:
6683:
6679:
6675:
6671:
6667:
6663:
6659:
6655:
6651:
6650:
6645:
6639:
6638:
6634:
6632:
6623:
6619:
6615:
6611:
6607:
6603:
6599:
6595:
6591:
6590:
6585:
6578:
6576:
6574:
6572:
6563:
6559:
6555:
6551:
6547:
6543:
6539:
6535:
6531:
6527:
6523:
6519:
6515:
6511:
6507:
6503:
6496:
6494:
6492:
6490:
6488:
6479:
6475:
6471:
6467:
6462:
6457:
6453:
6449:
6444:
6439:
6435:
6431:
6427:
6426:
6421:
6414:
6412:
6403:
6399:
6394:
6389:
6385:
6381:
6377:
6373:
6369:
6365:
6361:
6354:
6346:
6342:
6338:
6334:
6330:
6326:
6322:
6318:
6311:
6303:
6299:
6294:
6289:
6285:
6281:
6277:
6273:
6269:
6262:
6254:
6250:
6245:
6240:
6236:
6232:
6228:
6224:
6220:
6213:
6205:
6201:
6196:
6191:
6187:
6183:
6179:
6175:
6171:
6164:
6149:
6145:
6141:
6137:
6133:
6129:
6125:
6121:
6117:
6113:
6106:
6098:
6094:
6090:
6086:
6081:
6076:
6073:: 1167–1181.
6072:
6068:
6064:
6060:
6056:
6049:
6041:
6037:
6032:
6027:
6023:
6019:
6015:
6008:
6000:
5996:
5991:
5986:
5982:
5978:
5974:
5967:
5951:
5947:
5943:
5936:
5928:
5924:
5920:
5916:
5912:
5908:
5904:
5900:
5896:
5892:
5885:
5877:
5873:
5869:
5865:
5861:
5857:
5850:
5842:
5838:
5834:
5830:
5826:
5822:
5818:
5814:
5810:
5809:
5801:
5799:
5797:
5788:
5784:
5780:
5776:
5772:
5768:
5764:
5760:
5756:
5755:
5747:
5745:
5743:
5741:
5739:
5730:
5726:
5721:
5716:
5712:
5708:
5704:
5700:
5696:
5694:
5685:
5683:
5674:
5670:
5665:
5660:
5656:
5652:
5648:
5644:
5640:
5636:
5632:
5625:
5623:
5615:
5611:
5607:
5604:
5599:
5592:
5591:
5586:
5582:
5579:
5574:
5558:
5554:
5548:
5540:
5536:
5531:
5526:
5522:
5518:
5514:
5510:
5506:
5499:
5491:
5487:
5482:
5477:
5472:
5467:
5463:
5459:
5455:
5448:
5440:
5436:
5431:
5426:
5422:
5418:
5414:
5410:
5403:
5395:
5391:
5386:
5381:
5376:
5371:
5367:
5363:
5362:PLOS Genetics
5359:
5352:
5344:
5340:
5336:
5332:
5329:(1): 94–101.
5328:
5324:
5317:
5309:
5305:
5301:
5297:
5293:
5289:
5282:
5274:
5270:
5266:
5262:
5258:
5254:
5250:
5246:
5242:
5238:
5237:Ecotoxicology
5234:
5227:
5219:
5215:
5210:
5205:
5201:
5197:
5193:
5189:
5185:
5181:
5177:
5175:
5166:
5158:
5154:
5150:
5146:
5142:
5138:
5134:
5130:
5126:
5122:
5115:
5107:
5103:
5098:
5093:
5089:
5085:
5081:
5074:
5066:
5062:
5057:
5052:
5048:
5044:
5040:
5036:
5032:
5025:
5017:
5013:
5008:
5003:
4998:
4993:
4989:
4985:
4981:
4974:
4966:
4962:
4957:
4952:
4948:
4944:
4940:
4933:
4925:
4921:
4916:
4911:
4907:
4903:
4899:
4895:
4891:
4884:
4876:
4872:
4867:
4862:
4857:
4852:
4848:
4844:
4840:
4836:
4832:
4825:
4817:
4813:
4808:
4803:
4799:
4795:
4791:
4784:
4782:
4766:
4762:
4758:
4752:
4737:
4733:
4729:
4723:
4715:
4711:
4706:
4701:
4697:
4693:
4688:
4683:
4679:
4675:
4671:
4667:
4663:
4656:
4648:
4644:
4639:
4634:
4630:
4626:
4622:
4618:
4614:
4607:
4591:
4587:
4581:
4565:
4561:
4557:
4551:
4535:
4531:
4527:
4520:
4512:
4508:
4503:
4498:
4494:
4490:
4486:
4482:
4478:
4471:
4469:
4459:
4454:
4450:
4443:
4435:
4431:
4426:
4421:
4416:
4411:
4407:
4403:
4400:(8): e23094.
4399:
4395:
4391:
4384:
4376:
4372:
4367:
4362:
4357:
4352:
4348:
4344:
4340:
4336:
4332:
4325:
4317:
4313:
4308:
4303:
4299:
4295:
4292:(7424): 333.
4291:
4287:
4283:
4276:
4268:
4264:
4259:
4254:
4249:
4244:
4240:
4236:
4232:
4225:
4211:on 2017-04-18
4210:
4206:
4202:
4199:(5): 446–53.
4198:
4194:
4190:
4183:
4175:
4171:
4166:
4161:
4156:
4151:
4147:
4143:
4139:
4132:
4130:
4113:
4109:
4103:
4095:
4091:
4086:
4081:
4077:
4073:
4069:
4065:
4061:
4054:
4046:
4042:
4037:
4032:
4027:
4022:
4018:
4014:
4010:
4003:
3995:
3991:
3986:
3981:
3977:
3973:
3969:
3965:
3961:
3957:
3953:
3946:
3938:
3934:
3929:
3924:
3919:
3914:
3910:
3906:
3902:
3898:
3894:
3887:
3876:September 23,
3871:
3867:
3863:
3857:
3842:
3838:
3834:
3828:
3820:
3814:
3810:
3803:
3795:
3791:
3786:
3781:
3777:
3773:
3769:
3765:
3761:
3754:
3739:
3735:
3728:
3713:
3709:
3705:
3699:
3691:
3687:
3682:
3677:
3673:
3669:
3665:
3658:
3650:
3649:
3645:
3637:
3629:
3625:
3621:
3617:
3613:
3609:
3605:
3601:
3597:
3593:
3585:
3577:
3573:
3568:
3563:
3559:
3555:
3551:
3544:
3542:
3540:
3523:
3519:
3515:
3508:
3506:
3497:
3493:
3489:
3485:
3480:
3475:
3471:
3467:
3463:
3459:
3458:G3 (Bethesda)
3455:
3448:
3440:
3436:
3431:
3426:
3422:
3418:
3414:
3410:
3406:
3399:
3391:
3387:
3383:
3379:
3375:
3371:
3367:
3363:
3356:
3348:
3344:
3340:
3336:
3331:
3326:
3322:
3318:
3317:
3312:
3305:
3297:
3293:
3289:
3285:
3281:
3277:
3273:
3269:
3262:
3254:
3250:
3246:
3242:
3238:
3234:
3230:
3226:
3222:
3215:
3207:
3203:
3199:
3195:
3191:
3187:
3180:
3172:
3168:
3164:
3160:
3155:
3150:
3146:
3142:
3138:
3134:
3127:
3125:
3123:
3121:
3112:
3111:
3106:
3104:
3098:
3092:
3090:
3073:
3069:
3065:
3061:
3060:"Danio rerio"
3055:
3048:(3): 273–280.
3047:
3043:
3039:
3038:Danio kyathit
3032:
3016:
3012:
3006:
3004:
2995:
2992:
2985:
2983:
2966:
2962:
2956:
2948:
2944:
2940:
2936:
2932:
2928:
2924:
2920:
2913:
2911:
2909:
2907:
2905:
2903:
2894:
2891:
2884:
2882:
2880:
2863:
2859:
2855:
2848:
2840:
2836:
2831:
2826:
2822:
2818:
2814:
2807:
2805:
2803:
2801:
2792:
2788:
2783:
2778:
2774:
2770:
2766:
2762:
2758:
2756:
2747:
2731:
2727:
2723:
2717:
2715:
2706:
2702:
2697:
2692:
2688:
2684:
2680:
2676:
2672:
2665:
2663:
2661:
2659:
2651:
2647:
2642:
2640:
2631:
2627:
2622:
2617:
2613:
2609:
2605:
2601:
2597:
2590:
2588:
2578:
2573:
2568:
2563:
2559:
2555:
2551:
2544:
2542:
2540:
2523:
2519:
2515:
2509:
2501:
2497:
2492:
2487:
2483:
2479:
2475:
2471:
2467:
2463:
2459:
2457:
2447:
2431:
2426:
2422:
2418:
2417:
2412:
2410:
2401:
2399:
2397:
2395:
2390:
2380:
2377:
2375:
2372:
2369:
2366:
2365:
2359:
2350:
2348:
2338:
2329:
2320:
2317:
2313:
2309:
2305:
2294:
2292:
2288:
2284:
2280:
2276:
2267:
2264:
2260:
2256:
2252:
2248:
2244:
2240:
2235:
2233:
2229:
2225:
2216:
2207:
2204:
2194:
2190:
2188:
2181:Immune system
2178:
2176:
2172:
2168:
2164:
2153:
2151:
2146:
2141:
2139:
2135:
2131:
2127:
2123:
2119:
2115:
2100:
2097:
2093:
2089:
2085:
2081:
2077:
2067:
2065:
2060:
2056:
2045:
2043:
2039:
2028:
2027:assay model.
2026:
2021:
2012:
2007:
1998:
1996:
1992:
1988:
1984:
1973:
1971:
1967:
1963:
1953:
1951:
1947:
1943:
1939:
1935:
1934:
1933:Chanos chanos
1929:
1928:
1923:
1918:
1916:
1915:
1910:
1909:
1904:
1903:
1898:
1897:
1892:
1891:
1886:
1885:
1880:
1876:
1872:
1868:
1864:
1860:
1856:
1852:
1848:
1844:
1837:
1832:
1830:
1826:
1822:
1812:
1810:
1806:
1802:
1792:
1790:
1786:
1782:
1773:
1771:
1768:, but not in
1767:
1763:
1758:
1754:
1750:
1746:
1742:
1738:
1734:
1731:
1727:
1717:
1714:
1710:
1705:
1703:
1699:
1695:
1691:
1687:
1683:
1679:
1675:
1665:
1663:
1658:
1656:
1652:
1648:
1644:
1640:
1636:
1632:
1628:
1619:
1617:
1613:
1609:
1605:
1601:
1597:
1593:
1589:
1585:
1584:
1579:
1575:
1572:In 1999, the
1565:
1563:
1559:
1555:
1551:
1547:
1543:
1539:
1538:
1533:
1529:
1525:
1521:
1517:
1513:
1510:are vital in
1509:
1505:
1496:
1494:
1489:
1485:
1481:
1477:
1473:
1469:
1465:
1461:
1457:
1453:
1443:
1441:
1436:
1431:
1429:
1425:
1422:
1418:
1414:
1410:
1400:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1365:
1363:
1362:microinjected
1358:
1354:
1350:
1346:
1342:
1339:
1335:
1331:
1327:
1323:
1313:
1311:
1307:
1303:
1299:
1285:
1283:
1279:
1273:
1271:
1267:
1266:Wnt signaling
1262:
1258:
1254:
1251:heal without
1250:
1246:
1242:
1237:
1233:
1229:
1225:
1221:
1216:
1214:
1210:
1206:
1202:
1198:
1194:
1190:
1186:
1182:
1178:
1175:
1171:
1161:
1158:
1154:
1149:
1147:
1143:
1139:
1129:
1127:
1123:
1119:
1115:
1111:
1107:
1103:
1099:
1095:
1091:
1087:
1083:
1078:
1076:
1072:
1068:
1064:
1060:
1056:
1052:
1048:
1045:
1041:
1037:
1033:
1029:
1022:
1018:
1014:
1010:
1005:
998:
994:
989:
980:
978:
977:
972:
968:
954:
951:
948:
945:
942:
939:
936:
933:
930:
927:
924:
921:
918:
915:
912:
909:
906:
903:
900:
897:
894:
891:
888:
885:
882:
879:
876:
873:
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867:
864:
861:
858:
855:
852:
849:
846:
843:
840:
837:
834:
831:
828:
825:
822:
819:
816:
813:
812:
810:
808:
804:
800:
790:
788:
784:
780:
775:
773:
769:
765:
764:Danio frankei
756:
752:
750:
746:
742:
738:
728:
726:
721:
718:
715:
714:
713:Mycobacterium
709:
705:
704:microsporidia
701:
700:
695:
684:
682:
678:
673:
671:
667:
663:
662:phytoplankton
659:
655:
645:
643:
639:
634:
632:
626:
622:
620:
619:model species
616:
612:
607:
603:
599:
595:
586:
577:
575:
571:
567:
566:escape reflex
563:
558:
556:
552:
542:
539:
535:
531:
527:
523:
513:
510:
506:
502:
498:
488:
486:
482:
477:
475:
474:
473:Danio kyathit
469:
468:Eastern Ghats
465:
461:
457:
453:
449:
445:
441:
426:
424:
420:
419:
414:
413:
408:
404:
400:
399:
394:
384:
382:
378:
374:
370:
366:
362:
358:
354:
350:
347:
342:
340:
336:
335:tropical fish
332:
328:
327:aquarium fish
324:
323:Cypriniformes
321:
317:
313:
309:
305:
304:
299:
286:
283:
279:
276:
272:
269:
265:
264:Danio frankei
262:
258:
255:
251:
248:
244:
241:
237:
234:
230:
227:
226:
224:
221:
217:
212:
206:
204:
198:
195:
194:Binomial name
191:
187:
186:
185:D. rerio
181:
178:
177:
174:
173:
169:
166:
165:
162:
159:
156:
155:
152:
149:
146:
145:
142:
141:Cypriniformes
139:
136:
135:
132:
129:
126:
125:
122:
119:
116:
115:
112:
109:
106:
105:
102:
99:
96:
95:
90:
85:
81:
75:
70:
69:Least Concern
59:
55:
50:
45:
41:
36:
33:
29:
26:
22:
9838:
9603:
9568:
9561:
9554:
9547:
9540:
9533:
9521:
9504:
9497:
9490:
9486:Lambda phage
9427:
9381:
9265:. Retrieved
9256:
9226:
9205:
9201:
9164:
9161:PLOS Biology
9160:
9123:
9119:
9109:December 15,
9107:. Retrieved
9103:the original
9098:
9069:
9056:. Retrieved
9028:
9024:
8969:
8965:
8955:
8918:
8914:
8856:
8852:
8846:
8813:
8809:
8803:
8766:
8762:
8712:
8708:
8698:
8665:
8661:
8654:
8619:
8615:
8605:
8570:
8566:
8556:
8521:
8517:
8507:
8472:
8468:
8458:
8423:
8419:
8409:
8401:the original
8394:
8385:
8358:
8354:
8344:
8309:
8305:
8295:
8260:
8256:
8246:
8209:
8205:
8195:
8160:
8156:
8146:
8111:
8107:
8097:
8070:
8066:
8056:
8021:
8015:
7990:
7986:
7980:
7945:
7941:
7931:
7914:1887/3736301
7897:(1): 39–49.
7894:
7890:
7880:
7854:10.3791/3781
7845:
7835:
7798:
7794:
7784:
7749:
7745:
7735:
7703:(1): 38–47.
7700:
7696:
7686:
7661:
7657:
7651:
7600:
7594:
7559:
7555:
7545:
7535:November 15,
7533:. Retrieved
7529:the original
7519:
7486:
7482:
7476:
7433:
7429:
7419:
7382:
7378:
7368:
7358:November 15,
7356:. Retrieved
7348:Sciencedaily
7347:
7338:
7295:
7291:
7281:
7238:
7234:
7224:
7212:. Retrieved
7203:
7194:
7169:
7165:
7159:
7124:
7120:
7110:
7075:
7071:
7025:
7021:
6977:
6973:
6963:
6941:(1): 66–77.
6938:
6934:
6928:
6916:. Retrieved
6902:
6867:
6863:
6853:
6810:
6806:
6796:
6786:
6709:
6703:
6653:
6647:
6593:
6587:
6583:
6524:): 329–345.
6505:
6501:
6429:
6423:
6367:
6363:
6353:
6320:
6316:
6310:
6275:
6271:
6261:
6229:(1): 12–23.
6226:
6222:
6212:
6177:
6173:
6163:
6152:. Retrieved
6119:
6115:
6105:
6062:
6058:
6048:
6021:
6017:
6007:
5980:
5976:
5966:
5954:. Retrieved
5945:
5935:
5894:
5890:
5884:
5859:
5855:
5849:
5812:
5806:
5758:
5752:
5702:
5698:
5692:
5638:
5634:
5598:
5588:
5573:
5561:. Retrieved
5547:
5512:
5508:
5498:
5461:
5457:
5447:
5421:10.3791/1115
5412:
5402:
5365:
5361:
5351:
5326:
5322:
5316:
5294:(1): 78–85.
5291:
5287:
5281:
5240:
5236:
5232:
5226:
5183:
5179:
5173:
5165:
5127:(1): 19–25.
5124:
5120:
5114:
5087:
5083:
5073:
5038:
5034:
5024:
4987:
4984:PLOS Biology
4983:
4973:
4946:
4943:Cell Reports
4942:
4932:
4900:(1): 71–77.
4897:
4893:
4883:
4838:
4834:
4824:
4797:
4793:
4769:. Retrieved
4760:
4751:
4740:. Retrieved
4732:ScienceDaily
4731:
4722:
4669:
4665:
4655:
4620:
4616:
4606:
4596:November 15,
4594:. Retrieved
4590:the original
4580:
4570:November 15,
4568:. Retrieved
4550:
4538:. Retrieved
4529:
4519:
4484:
4480:
4458:the original
4452:
4442:
4397:
4393:
4383:
4338:
4334:
4324:
4289:
4285:
4275:
4241:(10): e281.
4238:
4235:PLOS Biology
4234:
4224:
4213:. Retrieved
4209:the original
4196:
4192:
4182:
4145:
4141:
4116:. Retrieved
4102:
4067:
4063:
4053:
4019:(11): 1941.
4016:
4012:
4002:
3959:
3955:
3945:
3903:(2): e4361.
3900:
3896:
3886:
3874:. Retrieved
3870:the original
3856:
3845:. Retrieved
3836:
3827:
3808:
3802:
3767:
3764:EMBO Reports
3763:
3753:
3742:. Retrieved
3727:
3716:. Retrieved
3707:
3698:
3671:
3667:
3657:
3647:
3643:
3636:
3595:
3591:
3584:
3557:
3553:
3528:February 11,
3526:. Retrieved
3517:
3461:
3457:
3447:
3412:
3408:
3398:
3365:
3361:
3355:
3320:
3314:
3304:
3271:
3267:
3261:
3228:
3224:
3220:
3214:
3189:
3185:
3179:
3139:(1): 13–34.
3136:
3132:
3108:
3102:
3076:. Retrieved
3072:the original
3063:
3054:
3045:
3041:
3037:
3031:
3019:. Retrieved
2994:
2990:
2969:. Retrieved
2955:
2925:(1): 21–40.
2922:
2918:
2893:
2889:
2866:. Retrieved
2847:
2820:
2816:
2764:
2760:
2754:
2746:
2734:. Retrieved
2725:
2678:
2674:
2603:
2599:
2557:
2553:
2526:. Retrieved
2517:
2508:
2465:
2461:
2455:
2446:
2434:. Retrieved
2420:
2414:
2408:
2379:Denison barb
2356:
2344:
2335:
2326:
2308:osteoporosis
2303:
2300:
2282:
2278:
2273:
2236:
2221:
2202:
2200:
2191:
2187:inflammation
2184:
2159:
2145:neural crest
2142:
2137:
2111:
2073:
2051:
2038:rosuvastatin
2034:
2031:Drug screens
2016:
1994:
1979:
1959:
1949:
1941:
1931:
1925:
1919:
1912:
1906:
1900:
1894:
1888:
1882:
1881:– Goldfish (
1835:
1833:
1823:, including
1821:fish farming
1818:
1798:
1785:transferrins
1780:
1779:
1737:RNA splicing
1735:to initiate
1723:
1720:RNA splicing
1706:
1685:
1681:
1671:
1659:
1650:
1638:
1634:
1630:
1627:Transgenesis
1625:
1622:Transgenesis
1615:
1611:
1591:
1581:
1577:
1573:
1571:
1535:
1532:Eomesodermin
1511:
1502:
1471:
1463:
1455:
1449:
1439:
1432:
1406:
1397:ChIP-on-chip
1366:
1321:
1319:
1296:
1274:
1261:lateral line
1249:spinal cords
1217:
1174:lateral line
1167:
1164:Regeneration
1150:
1135:
1106:neurobiology
1081:
1079:
1070:
1027:
1026:
974:
970:
966:
964:
952:
946:
940:
934:
928:
922:
916:
910:
904:
898:
892:
886:
880:
874:
868:
862:
856:
850:
844:
838:
833:AB/Tuebingen
832:
826:
820:
814:
806:
796:
776:
763:
761:
734:
722:
719:
711:
707:
697:
690:
677:brine shrimp
674:
651:
635:
627:
623:
614:
597:
591:
580:Reproduction
570:lateral line
559:
548:
519:
505:rice paddies
503:, ponds and
494:
478:
471:
437:
429:Distribution
416:
410:
407:sister-group
396:
390:
373:regenerative
343:
330:
302:
301:
297:
295:
284:
277:
270:
263:
256:
249:
242:
235:
228:
202:
200:
184:
183:
171:
31:
25:
9734:iNaturalist
9648:Danio_rerio
9634:Danio rerio
9628:Wikispecies
9604:Danio rerio
9535:Arabidopsis
9506:Tetrahymena
9382:Danio rerio
9377:at the IGIB
9364:at the IGIB
9204:Danio rerio
9167:(5): E148.
8874:2066/153047
8859:: 106–113.
8715:: 1253710.
8073:: 179–192.
7617:10261/44975
6781:PMC10014602
6720:: 681–691.
6660:: 173–197.
6644:Sive, Hazel
6600:: 209–240.
6584:Danio rerio
5956:January 23,
5856:Development
5819:: 219–239.
5765:: 561–613.
5693:Danio rerio
5603:FishMap Zv8
5563:October 23,
5233:Danio rerio
5174:Danio rerio
3646:Danio Rerio
3560:(1): 6–19.
3221:Danio rerio
3103:Danio rerio
2993:Danio rerio
2892:Danio rerio
2736:February 4,
2528:17 November
2456:Danio rerio
2436:19 November
2409:Danio rerio
2263:glial cells
2228:ultraviolet
2064:paracetamol
1887:), Medaka (
1875:Percomorpha
1789:vertebrates
1692:as well as
1662:CRISPR-Cas9
1649:/β-catenin/
1608:orthologous
1495:sequences.
1393:microarrays
1369:duplication
1243:, known as
1228:MĂĽller glia
1017:melanocytes
1009:mutagenesis
743:, red, and
670:crustaceans
658:zooplankton
598:Danio rerio
516:Description
501:oxbow lakes
405:. It has a
398:Brachydanio
383:strains.
339:subtropical
331:zebra danio
303:Danio rerio
278:Nuria rerio
211:F. Hamilton
203:Danio rerio
157:Subfamily:
32:Danio rerio
9950:Categories
9854:Q106388306
9556:Drosophila
9549:C. elegans
9523:Neurospora
9214:B003KFCWKS
9093:Sharpe S.
9058:2024-01-26
8972:: 573303.
8921:(91): 91.
8355:Stem Cells
7801:: 159807.
6813:(1): 145.
6520:(ANZMBS) (
6154:2022-12-05
5121:Lab Animal
4771:2012-06-02
4742:2018-03-09
4215:2012-11-15
3847:2019-06-17
3744:2024-03-05
3718:2018-03-12
3668:Aging Cell
3464:(1): 3–9.
3154:2381/27758
2577:1887/49224
2385:References
2092:absorption
2062:model for
2025:teratology
1991:DNA repair
1976:DNA repair
1970:fluoxetine
1938:Cyprinidae
1899:), Roach (
1805:homozygous
1783:has three
1702:xenografts
1678:metastasis
1528:morpholino
1508:homeoboxes
1493:nucleotide
1476:vertebrate
1456:D. rerio's
1454:published
1357:expression
1338:Morpholino
1332:or modify
1312:analysis.
1257:hair cells
1177:hair cells
1170:regenerate
1157:homozygous
1116:research,
1098:teratology
1094:toxicology
1036:vertebrate
991:Zebrafish
851:Darjeeling
772:Xanthistic
737:transgenic
654:omnivorous
545:Psychology
522:caudal fin
485:fish farms
481:introduced
460:Kosi River
403:Cyprinidae
381:transgenic
361:teratology
346:vertebrate
316:Cyprinidae
161:Danioninae
151:Cyprinidae
9569:Zebrafish
9425:View the
9120:Zebrafish
9025:Behaviour
7468:264449103
7452:1534-5807
7214:April 28,
7172:: 71–93.
7072:Zebrafish
6980:: 58–70.
6918:March 19,
6734:1359-4184
6674:1527-8204
6614:1753-5123
6546:1436-2228
6516:(JSMB) +
6512:(ESMB) +
6452:1664-302X
6434:Frontiers
6136:1940-3402
5833:0066-4197
5779:0066-4197
5157:227259359
5141:0093-7355
4540:4 October
4142:Molecules
2919:Zebrafish
2560:: 27–34.
2349:studies.
2243:stem cell
2224:cone cell
2130:oncogenes
2096:clearance
1995:Zebrafish
1873:, in the
1863:sea bream
1847:salmonids
1843:taxonomic
1829:parasites
1825:pathogens
1776:Orthology
1770:tetrapods
1713:oestrogen
1458:complete
1442:in 2013.
1415:(NCBI)'s
1341:antisense
1140:has been
1114:stem cell
1023:properly.
929:Tuebingen
925:(SJD/C32)
905:Singapore
887:Indonesia
875:Hong Kong
871:(HK/SING)
681:paramecia
602:ovulation
440:Himalayas
318:) of the
298:zebrafish
179:Species:
107:Kingdom:
101:Eukaryota
9894:10160075
9848:Wikidata
9752:11303984
9708:FishBase
9613:Wikidata
9475:genetics
9428:danRer10
9412:Archived
9371:Archived
9358:Archived
9305:Archived
9287:Archived
9267:June 15,
9261:Archived
9257:BBC News
9245:87708919
9193:15138510
9148:18940475
9140:18248189
9049:Archived
9045:41720603
8998:33015065
8947:30177968
8883:25600250
8838:21829206
8830:23903952
8795:30761080
8741:31828085
8690:33403358
8682:11746460
8646:24931439
8597:11584042
8548:24092878
8499:21303839
8450:16583129
8377:17525239
8336:20878782
8287:24998295
8238:23769806
8187:26324465
8138:24973748
8089:24643219
8048:23468113
8007:24865811
7972:24973749
7923:24188444
7872:22453760
7827:22811714
7776:21366518
7727:22228790
7678:18222541
7635:21948373
7578:17875807
7511:25428361
7503:15647335
7460:37875117
7411:21473762
7352:Archived
7330:21430780
7273:21430779
7208:Archived
7186:21261518
7151:29693322
7102:27632065
7042:26361349
7004:25461724
6955:20166227
6912:Archived
6894:30295906
6845:30644404
6791:33383303
6760:11962425
6752:22641177
6690:19597664
6682:26002061
6622:84107971
6562:23994075
6554:16670967
6522:Springer
6478:13050990
6470:24917852
6402:23798977
6337:19834483
6302:23552219
6253:26566657
6204:31031007
6148:Archived
6144:27698232
6097:14376483
6089:12023297
6040:15366023
5999:15239961
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5539:14500831
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5439:19274045
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3690:12882339
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1871:flatfish
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8938:6110173
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8637:4697731
8588:1734735
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7963:4073269
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7818:3395205
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6393:3689353
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3785:1559663
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3479:3178105
3430:7301644
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2943:S2CID
2755:Danio
2279:sapje
1960:In a
1950:Danio
1942:Danio
1839:'
1836:Danio
1730:U2AF2
1682:prkdc
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1193:TRPV4
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8642:PMID
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8332:PMID
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7823:PMID
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6920:2011
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1308:and
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1222:and
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931:(TU)
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