1267:. They form tetramers, with each subunit consisting of an extracellular amino terminal domain (ATD, which is involved tetramer assembly), an extracellular ligand binding domain (LBD, which binds glutamate), and a transmembrane domain (TMD, which forms the ion channel). The transmembrane domain of each subunit contains three transmembrane helices as well as a half membrane helix with a reentrant loop. The structure of the protein starts with the ATD at the N terminus followed by the first half of the LBD which is interrupted by helices 1,2 and 3 of the TMD before continuing with the final half of the LBD and then finishing with helix 4 of the TMD at the C terminus. This means there are three links between the TMD and the extracellular domains. Each subunit of the tetramer has a binding site for glutamate formed by the two LBD sections forming a clamshell like shape. Only two of these sites in the tetramer need to be occupied to open the ion channel. The pore is mainly formed by the half helix 2 in a way which resembles an inverted
477:(TMSs) are connected by intracellular and extracellular loop structures. Except the TMS 3-4 loop, their lengths are only 7-14 residues. The TMS 3-4 loop forms the largest part of the intracellular domain (ICD) and exhibits the most variable region between all of these homologous receptors. The ICD is defined by the TMS 3-4 loop together with the TMS 1-2 loop preceding the ion channel pore. Crystallization has revealed structures for some members of the family, but to allow crystallization, the intracellular loop was usually replaced by a short linker present in prokaryotic cys-loop receptors, so their structures as not known. Nevertheless, this intracellular loop appears to function in desensitization, modulation of channel physiology by pharmacological substances, and
2770:
activation requires the simultaneous binding of two different agonists. In addition to the binding of glutamate at the conventional agonist-binding site, the binding of glycine appears to be required for receptor activation. Because neither of these agonists alone can open this ion channel, glutamate and glycine are referred to as coagonists of the NMDA receptor. The physiologic significance of the glycine binding site is unclear because the normal extracellular concentration of glycine is believed to be saturating. However, recent evidence suggests that D-serine may be the endogenous agonist for this site.
1675:
2013:
216:
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1847:
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434:(one at the interface of each alpha subunit). When the acetylcholine binds it alters the receptor's configuration (twists the T2 helices which moves the leucine residues, which block the pore, out of the channel pathway) and causes the constriction in the pore of approximately 3 angstroms to widen to approximately 8 angstroms so that ions can pass through. This pore allows Na ions to flow down their
403:
254:
419:
specificity for (1) acetylcholine (AcCh), (2) serotonin, (3) glycine, (4) glutamate and (5) γ-aminobutyric acid (GABA) in vertebrates. The receptors are subdivided with respect to the type of ion that they conduct (anionic or cationic) and further into families defined by the endogenous ligand. They are usually pentameric with each subunit containing 4 transmembrane
36:
1913:, the voltage-dependent block by Mg is partially relieved, allowing ion influx through activated NMDA receptors. The resulting Ca influx can trigger a variety of intracellular signaling cascades, which can ultimately change neuronal function through activation of various kinases and phosphatases". Ligands include:
418:
residues in the N terminal extracellular domain. They are part of a larger family of pentameric ligand-gated ion channels that usually lack this disulfide bond, hence the tentative name "Pro-loop receptors". A binding site in the extracellular N-terminal ligand-binding domain gives them receptor
2769:
At membrane potentials more negative than approximately −50 mV, the Mg in the extracellular fluid of the brain virtually abolishes ion flux through NMDA receptor channels, even in the presence of glutamate. ... The NMDA receptor is unique among all neurotransmitter receptors in that its
257:
256:
261:
260:
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259:
1727:
and was only later given the label "AMPA receptor" after the selective agonist developed by Tage Honore and colleagues at the Royal Danish School of
Pharmacy in Copenhagen. AMPARs are found in many parts of the
346:
These receptor proteins are typically composed of at least two different domains: a transmembrane domain which includes the ion pore, and an extracellular domain which includes the ligand binding location (an
3280:
2208:
By understanding the mechanism and exploring the chemical/biological/physical component that could function on those receptors, more and more clinical applications are proven by preliminary experiments or
335:. If these receptors are ligand-gated ion channels, a resulting conformational change opens the ion channels, which leads to a flow of ions across the cell membrane. This, in turn, results in either a
3141:
Heun, R; Coral, RM; Ahokas, A; Nicolini, H; Teixeira, JM; Dehelean, P (2013). "1643 – Efficacy of agomelatine in more anxious elderly depressed patients. A randomized, double-blind study vs placebo".
351:
binding site). This modularity has enabled a 'divide and conquer' approach to finding the structure of the proteins (crystallising each domain separately). The function of such receptors located at
2338:
438:
into the cell. With a sufficient number of channels opening at once, the inward flow of positive charges carried by Na ions depolarizes the postsynaptic membrane sufficiently to initiate an
2901:
Yarotskyy V, Glushakov AV, Sumners C, Gravenstein N, Dennis DM, Seubert CN, Martynyuk AE (May 2005). "Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine".
423:
constituting the transmembrane domain, and a beta sheet sandwich type, extracellular, N terminal, ligand binding domain. Some also contain an intracellular domain like shown in the image.
258:
2663:"International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update"
473:
Cys-loop receptors have structural elements that are well conserved, with a large extracellular domain (ECD) harboring an alpha-helix and 10 beta-strands. Following the ECD, four
1909:
on the receptor blocks ion flux through the NMDA receptor channel. "However, when neurons are depolarized, for example, by intense activation of colocalized postsynaptic
2237:
pathway, which have shown its efficacy in the treatment of anxious depression during clinical trials, study also suggests the efficacy in the treatment of atypical and
2355:
183:
2016:
Figure 1. Schematic representation showing the membrane topology of a typical P2X receptor subunit. First and second transmembrane domains are labeled TM1 and TM2.
2831:
Cao X, Cui Z, Feng R, Tang YP, Qin Z, Mei B, Tsien JZ (March 2007). "Maintenance of superior learning and memory function in NR2B transgenic mice during ageing".
4096:
5006:
3284:
3175:
Brunton, L; Chabner, B; Knollman, B (2010). Goodman and Gilman's The
Pharmacological Basis of Therapeutics (12th ed.). New York: McGraw-Hill Professional.
5555:
4741:
3993:
3926:
445:
A bacterial homologue to an LIC has been identified, hypothesized to act nonetheless as a chemoreceptor. This prokaryotic nAChR variant is known as the
2222:
5653:
2400:"Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels"
2381:
2710:
Honoré T, Lauridsen J, Krogsgaard-Larsen P (January 1982). "The binding of AMPA, a structural analogue of glutamic acid, to rat brain membranes".
2356:
Purves, Dale, George J. Augustine, David
Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008).
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127:
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3329:
6769:
5548:
4937:
4920:
4915:
4910:
4905:
3193:
Avedisova, A; Marachev, M (2013). "2639 – The effectiveness of agomelatine (valdoxan) in the treatment of atypical depression".
1278:
The AMPA receptor bound to a glutamate antagonist showing the amino terminal, ligand binding, and transmembrane domain, PDB 3KG2
4942:
4040:
3312:
3180:
2365:
95:
203:
4994:
4175:
2343:
2753:
Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 5: Excitatory and
Inhibitory Amino Acids". In Sydor A, Brown RY (eds.).
7065:
7055:
4892:
3913:
2281:
2276:
1723:. The receptor was first named the "quisqualate receptor" by Watkins and colleagues after a naturally occurring agonist
6922:
6866:
5541:
4678:
2033:. They form trimers with two transmembrane helices per subunit and both the C and N termini on the intracellular side.
387:
6575:
5964:
5952:
3234:
2762:
2286:
6759:
6308:
5984:
5861:
1943:
610:
427:
481:. Motifs important for trafficking are therein, and the ICD interacts with scaffold proteins enabling inhibitory
7050:
7030:
6941:
6855:
5271:
4270:
4048:
3364:
2296:
478:
5533:
6927:
5997:
5293:
3130:
Azheimer's disease - donepezil, galantamine, rivastigmine and memantine (review): final appraisal determination
191:
7020:
6749:
6403:
6397:
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3413:
1859:
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6916:
6688:
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6604:
6301:
5143:
340:
3129:
2217:
is approved by the U.S. F.D.A and the
European Medicines Agency for the treatment of moderate-to-severe
2193:
have their effects, although unequivocal evidence of this is yet to be established. In particular, the
266:
Ligand-gated ion channel showing the binding of transmitter (Tr) and changing of membrane potential (Vm)
7045:
7010:
6670:
6509:
6496:
6467:
6412:
6019:
5976:
3321:
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1863:
839:
187:
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7025:
6966:
6483:
5819:
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3707:
3252:
108:
6860:
6806:
6791:
6763:
6544:
6539:
6530:
3748:
3624:
3290:
2874:
Dingledine R, Borges K, Bowie D, Traynelis SF (March 1999). "The glutamate receptor ion channels".
2271:
1958:
435:
406:
Nicotinic acetylcholine receptor in closed state with predicted membrane boundaries shown, PDB 2BG9
7035:
6961:
6932:
6900:
6730:
6535:
6491:
6442:
6373:
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2291:
1893:
at these receptors. When the NMDA receptor is activated by the binding of two co-agonists, the
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6220:
5523:
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3502:
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1719:(CNS). Its name is derived from its ability to be activated by the artificial glutamate analog
1716:
1704:
1611:
1605:
1562:
1556:
1550:
1544:
1158:
1152:
1146:
1042:
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1030:
999:
993:
987:
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946:
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934:
928:
764:
758:
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694:
688:
682:
676:
670:
664:
658:
2132:
2126:
2120:
2114:
2108:
2102:
2096:
1736:. The AMPA receptor GluA2 (GluR2) tetramer was the first glutamate receptor ion channel to be
1654:
1648:
1496:
1435:
1429:
1423:
1417:
1411:
1348:
1342:
1336:
1330:
1218:
1212:
1206:
1200:
1119:
1100:
1081:
1062:
828:
808:
788:
576:
570:
564:
558:
552:
430:. It consists of a pentamer of protein subunits (typically ααβγδ), with two binding sites for
7015:
7005:
6973:
6817:
6550:
6437:
5568:
3298:
2301:
1240:
852:
367:
348:
309:
6978:
6822:
6675:
6628:
3396:
3036:"Actions of anesthetics on ligand-gated ion channels: role of receptor subunit composition"
2462:
1886:
474:
170:
8:
6599:
6387:
6233:
2325:
1972:
1879:
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1701:
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to pass through the membrane in response to the binding of a chemical messenger (i.e. a
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6422:
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5771:
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4863:
3739:
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2735:
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2662:
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2613:
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2555:
2485:
2450:
2375:
2306:
1984:
1918:
1898:
515:
411:
391:
379:
320:
3276:"1.A.9 The Neurotransmitter Receptor, Cys loop, Ligand-gated Ion Channel (LIC) Family"
3230:
3206:
3154:
2426:
2399:
132:
6895:
6800:
6623:
6416:
3901:
3214:
3176:
3162:
3103:
3060:
3016:
2975:
2918:
2883:
2848:
2844:
2813:
2758:
2727:
2692:
2643:
2629:
2587:
2531:
2490:
2431:
2361:
1902:
1890:
1268:
383:
382:. LICs are classified into three superfamilies which lack evolutionary relationship:
178:
100:
3115:
3072:
2930:
2860:
2739:
64:
6885:
6679:
6594:
6348:
6078:
5811:
4670:
3651:
3202:
3150:
3095:
3050:
3006:
2965:
2957:
2910:
2840:
2803:
2795:
2719:
2682:
2674:
2633:
2625:
2577:
2567:
2521:
2510:"Structure and function of the glycine receptor and related nicotinicoid receptors"
2480:
2470:
2421:
2411:
2266:
1381:
1261:
1172:
439:
371:
324:
313:
166:
144:
6813:
6725:
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6428:
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6382:
6365:
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5206:
3346:
3275:
2475:
1764:
1737:
1724:
120:
76:
3241:
3055:
6505:
6360:
6343:
5645:
5597:
5002:
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2258:
1996:
1778:
1733:
1674:
891:
522:
336:
328:
6999:
6741:
6640:
6632:
6615:
6554:
6123:
6053:
5637:
5589:
4956:
4629:
2572:
2556:"The Intracellular Loop of the Glycine Receptor: It's not all about the Size"
1947:
1910:
1897:
channel opens, allowing Na and Ca to flow into the cell, in turn raising the
1855:
1804:
1688:
1474:
1304:
1264:
431:
414:
are named after a characteristic loop formed by a disulfide bond between two
286:
246:
234:
4989:
4887:
2799:
6720:
6586:
6569:
6324:
6241:
5309:
4700:
3107:
3020:
2979:
2922:
2914:
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2852:
2817:
2696:
2647:
2591:
2535:
2526:
2509:
2494:
2435:
2416:
2230:
2058:
2021:
1988:
1906:
360:
3086:
Mount C, Downton C (July 2006). "Alzheimer disease: progress or profit?".
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2961:
2731:
104:
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6850:
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6476:
6356:
5564:
5239:
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5111:
4950:
3325:
3011:
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2678:
2226:
2202:
2186:
2012:
1951:
1834:
1760:
420:
356:
289:
242:
2205:
agents at concentrations similar to those used in clinical anaesthesia.
6703:
6518:
5219:
4585:
3953:
3921:
3262:
3242:"Revised Recommendations for Nomenclature of Ligand-Gated Ion Channels"
3099:
2451:"Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors"
2027:
2000:
1980:
1921:
1830:
1826:
1800:
1786:
364:
215:
88:
2757:(2nd ed.). New York, USA: McGraw-Hill Medical. pp. 124–125.
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1708:
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20:
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2900:
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3634:
3629:
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3556:
2755:
2252:
1992:
1976:
1966:
1939:
1929:
1871:
1744:
415:
305:
71:
3034:
Harris RA, Mihic SJ, Dildy-Mayfield JE, Machu TK (November 1995).
2995:"The effects of general anaesthetics on ligand-gated ion channels"
1846:
6377:
6168:
6163:
5912:
5444:
5201:
5037:
3538:
3533:
3528:
2190:
1933:
1878:). Studies show that the NMDA receptor is involved in regulating
1875:
1822:
1712:
1490:
1486:
652:
482:
352:
301:
83:
2709:
2612:
Collingridge GL, Olsen RW, Peters J, Spedding M (January 2009).
1274:
245:
portion of the receptor opens, allowing ions to pass across the
6890:
6459:
6339:
6158:
6153:
6148:
6143:
6138:
6133:
5932:
5927:
5922:
5917:
5907:
5902:
5897:
5892:
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5872:
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5717:
5709:
5701:
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5121:
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331:. The neurotransmitter then binds to receptors located on the
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4113:
4108:
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4003:
3998:
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1642:
1638:
1482:
1405:
1401:
1397:
1393:
1389:
1324:
1320:
1316:
1312:
1194:
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3281:
Creative
Commons Attribution-ShareAlike 3.0 Unported License
2221:, and has now received a limited recommendation by the UK's
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1962:
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electrical signal. Many LICs are additionally modulated by
359:
released neurotransmitter directly and very quickly into a
225:
160:
115:
59:
3279:, which is licensed in a way that permits reuse under the
2946:"General anaesthetic actions on ligand-gated ion channels"
4008:
3968:
3248:. International Union of Basic and Clinical Pharmacology.
2210:
449:
receptor, after the species in which it was identified;
375:
1901:. Thus, the NMDA receptor is an excitatory receptor. At
3140:
35:
29:
Neurotransmitter-gated ion-channel transmembrane region
19:"Ionotropic" redirects here, not to be confused with
2248:
1885:
The name "NMDA receptor" is derived from the ligand
6232:
2752:
2398:Tasneem A, Iyer LM, Jakobsson E, Aravind L (2004).
2026:ATP-gated channels open in response to binding the
2553:
3192:
2943:
2223:National Institute for Health and Care Excellence
1905:, the binding of Mg or Zn at their extracellular
1251:
6997:
5478:
1732:and are the most commonly found receptor in the
3122:
2448:
2225:for patients who fail other treatment options.
426:The prototypic ligand-gated ion channel is the
2830:
2614:"A nomenclature for ligand-gated ion channels"
2393:
2391:
1862: – is a ligand-gated ion channel that is
488:
6309:
5549:
3306:
3246:IUPHAR Database of Receptors and Ion Channels
2660:
864:
3085:
2986:
2937:
2380:: CS1 maint: multiple names: authors list (
339:, for an excitatory receptor response, or a
3128:NICE technology appraisal January 18, 2011
3027:
2654:
2501:
2442:
2388:
6316:
6302:
5556:
5542:
3313:
3299:
3079:
292:proteins which open to allow ions such as
34:
6517:
3897:
3342:
3054:
3010:
2969:
2944:Krasowski MD, Harrison NL (August 1999).
2807:
2686:
2637:
2581:
2571:
2525:
2484:
2474:
2425:
2415:
2185:are likely to be the major site at which
834:ACHRE, CMS1D, CMS1E, CMS2A, FCCMS, SCCMS
16:Type of ion channel transmembrane protein
2746:
2607:
2605:
2603:
2601:
2326:"Gene Family: Ligand gated ion channels"
2229:, is a type of drug that acts on a dual
2011:
1850:Stylized depiction of an activated NMDAR
1845:
1673:
1273:
712:ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS
401:
252:
214:
5466:
3685:
3237:. Verified availability April 11, 2007.
2781:
2661:Olsen RW, Sieghart W (September 2008).
2554:Langlhofer G, Villmann C (2016-01-01).
241:When ligands bind to the receptor, the
6998:
6323:
3287:. All relevant terms must be followed.
2992:
2507:
2360:. Sinauer Associates. pp. 156–7.
1364:, GluR2, GluRB, GluR-B, GluR-K2, HBGR2
1358:, GluR1, GluRA, GluR-A, GluR-K1, HBGR1
6297:
5537:
5465:
4650:
3896:
3684:
3341:
3294:
2598:
2349:
2177:
2007:
397:
355:is to convert the chemical signal of
2950:Cellular and Molecular Life Sciences
2833:The European Journal of Neuroscience
2549:
2547:
2545:
4679:Calcium-activated chloride channels
2788:The New England Journal of Medicine
2560:Frontiers in Molecular Neuroscience
2514:The Journal of Biological Chemistry
2328:. HUGO Gene Nomenclature Committee.
2282:Cyclic nucleotide-gated ion channel
2277:Calcium-activated potassium channel
1969:; 3,5-dibromo-L-phenylalanine, etc.
1854:The N-methyl-D-aspartate receptor (
13:
6923:Angiotensin II receptor antagonist
6867:Endocannabinoid reuptake inhibitor
3749:Amiloride-sensitive cation channel
2724:10.1111/j.1471-4159.1982.tb10868.x
2449:Jaiteh M, Taly A, Hénin J (2016).
14:
7077:
6814:Acetylcholine receptor antagonist
6576:Norepinephrine reuptake inhibitor
4651:
3273:, this article uses content from
3235:European Bioinformatics Institute
3231:Ligand-Gated Ion Channel database
3224:
2542:
2287:Voltage-dependent calcium channel
1841:
770:CMS2A, SCCMS, ACHRB, CHRNB, CMS1D
2845:10.1111/j.1460-9568.2007.05431.x
2630:10.1016/j.neuropharm.2008.06.063
2251:
1944:aminocyclopropanecarboxylic acid
1669:
428:nicotinic acetylcholine receptor
281:), also commonly referred to as
6942:Vasopressin receptor antagonist
6856:Cannabinoid receptor antagonist
5272:Voltage-dependent anion channel
3365:Inositol trisphosphate receptor
3186:
3169:
3134:
2894:
2867:
2824:
2784:"Memory and the NMDA receptors"
2775:
2703:
2297:Inositol trisphosphate receptor
1870:and a co-agonist (i.e., either
1866:by the simultaneous binding of
1370:, GluR3, GluRC, GluR-C, GluR-K3
479:posttranslational modifications
6928:Endothelin receptor antagonist
6792:Acetylcholine receptor agonist
6551:Adrenergic receptor antagonist
5294:General bacterial porin family
2999:British Journal of Anaesthesia
2332:
2318:
1819:Negative allosteric modulators
1797:Positive allosteric modulators
1578:, NMDA-R2B, NR2B, hNR3, GluRε2
1258:ionotropic glutamate receptors
1252:Ionotropic glutamate receptors
388:ionotropic glutamate receptors
343:, for an inhibitory response.
1:
6760:Glutamate receptor antagonist
6676:Serotonin receptor antagonist
6629:Histamine receptor antagonist
6404:Negative allosteric modulator
6398:Positive allosteric modulator
3207:10.1016/S0924-9338(13)77272-9
3155:10.1016/S0924-9338(13)76634-3
2312:
1860:ionotropic glutamate receptor
155:Available protein structures:
6917:Adenosine reuptake inhibitor
6851:Cannabinoid receptor agonist
6770:Glutamate reuptake inhibitor
6689:Serotonin reuptake inhibitor
6600:Dopamine receptor antagonist
2782:Li F, Tsien JZ (July 2009).
2476:10.1371/journal.pone.0151934
2344:Dorland's Medical Dictionary
468:
7:
6605:Dopamine reuptake inhibitor
6527:Adrenergic receptor agonist
3263:www.guidetopharmacology.org
3056:10.1096/fasebj.9.14.7589987
2244:
814:ACHRD, CMS2A, FCCMS, SCCMS
489:Cationic cys-loop receptors
222:Ion-channel-linked receptor
10:
7082:
7066:Integral membrane proteins
7056:Transmembrane transporters
6896:Opioid receptor antagonist
6750:Glutamate receptor agonist
6671:Serotonin receptor agonist
6624:Histamine receptor agonist
4713:Chloride Channel Accessory
3322:Membrane transport protein
2201:receptors are affected by
2019:
1621:, NMDA-R3A, NMDAR-L, chi-1
865:Anionic cys-loop receptors
840:Zinc-activated ion channel
323:is excited, it releases a
18:
6954:
6909:
6876:
6841:
6782:
6740:
6711:
6702:
6661:
6614:
6595:Dopamine receptor agonist
6585:
6504:
6490:
6475:
6458:
6451:
6331:
6219:
6179:
6116:Voltage- and ligand-gated
6114:
6044:
6032:
6010:
5860:
5810:
5636:
5588:
5579:
5573:ligand-gated ion channels
5519:
5474:
5461:
5302:
5191:
4987:
4885:
4861:
4663:
4659:
4646:
4269:
4174:
4039:
3912:
3908:
3892:
3779:
3738:
3708:Epithelial sodium channel
3700:
3696:
3680:
3412:
3357:
3353:
3337:
2712:Journal of Neurochemistry
2183:Ligand-gated ion channels
1899:cell's electric potential
1678:AMPA receptor trafficking
1634:
1631:
1590:, NMDA-R2D, NR2D, GluRε4
1478:
1473:
1171:
890:
609:
271:Ligand-gated ion channels
197:
177:
159:
154:
150:
138:
126:
114:
94:
82:
70:
58:
50:
45:
33:
28:
6861:Endocannabinoid enhancer
6807:Cholinesterase inhibitor
6726:GABA receptor antagonist
3625:Cation channels of sperm
2573:10.3389/fnmol.2016.00041
2272:Acid-sensing ion channel
1959:N-methyl-D-aspartic acid
1957:Partial agonists :
1889:(NMDA), which acts as a
1584:, NMDA-R2C, NR2C, GluRε3
1572:, NMDA-R2A, NR2A, GluRε1
436:electrochemical gradient
40:Ligand-gated ion channel
6901:Enkephalinase inhibitor
6891:Opioid receptor agonist
6731:GABA reuptake inhibitor
6436:♦ Miscellaneous:
5862:Nicotinic acetylcholine
2993:Dilger JP (July 2002).
2876:Pharmacological Reviews
2800:10.1056/NEJMcibr0902052
2667:Pharmacological Reviews
2292:Receptor (biochemistry)
1376:, GluR4, GluRD, GluR-D
611:Nicotinic acetylcholine
327:from vesicles into the
7051:Transmembrane proteins
7031:Molecular neuroscience
6484:Ion channel modulators
2915:10.1124/mol.104.005983
2903:Molecular Pharmacology
2527:10.1074/jbc.R300035200
2417:10.1186/gb-2004-6-1-r4
2339:"ligand-gated channel"
2239:melancholic depression
2017:
1851:
1717:central nervous system
1705:transmembrane receptor
1679:
1518:, NMDA-R1, NR1, GluRξ1
1279:
858:ZAC1, L2m LICZ, LICZ1
475:transmembrane segments
407:
267:
250:
6721:GABA receptor agonist
5569:cell surface receptor
3701:Constitutively active
2962:10.1007/s000180050371
2508:Cascio M (May 2004).
2302:Metabotropic receptor
2015:
1849:
1677:
1457:, GluR7, GluR-7, EAA5
1451:, GluR6, GluR-6, EAA4
1445:, GluR5, GluR-5, EAA3
1277:
405:
265:
218:
7021:Ionotropic receptors
6234:Purinergic receptors
3283:, but not under the
2679:10.1124/pr.108.00505
2358:Neuroscience. 4th ed
1887:N-methyl-D-aspartate
1715:transmission in the
1694:quisqualate receptor
283:ionotropic receptors
6937:receptor antagonist
5468:By gating mechanism
3195:European Psychiatry
3143:European Psychiatry
2467:2016PLoSO..1151934J
2219:Alzheimer's disease
1880:synaptic plasticity
1858:) – a type of
1757:5-Fluorowillardiine
1740:. Ligands include:
1711:that mediates fast
1291:IUPHAR-recommended
1048:CAE2, ECA2, GEFSP3
878:IUPHAR-recommended
502:IUPHAR-recommended
333:postsynaptic neuron
7061:Transport proteins
6325:Pharmacomodulation
6002:β1δε - Muscle type
5581:Cys-loop receptors
4995:TRP cation channel
4893:CNG cation channel
4176:Tandem pore domain
3387:Ryanodine receptor
3100:10.1038/nm0706-780
3012:10.1093/bja/aef161
2307:Ryanodine receptor
2178:Clinical relevance
2045:IUPHAR-recommended
2018:
2008:ATP-gated channels
1985:dextropropoxyphene
1903:resting potentials
1852:
1680:
1469:, KA2, KA-2, EAA2
1280:
412:cys-loop receptors
408:
398:Cys-loop receptors
392:ATP-gated channels
384:cys-loop receptors
380:membrane potential
321:presynaptic neuron
268:
251:
7046:Membrane proteins
7011:Electrophysiology
6993:
6992:
6989:
6988:
6950:
6949:
6778:
6777:
6698:
6697:
6468:Enzyme inhibition
6291:
6290:
6287:
6286:
6215:
6214:
6046:Ligand-gated only
6028:
6027:
5531:
5530:
5515:
5514:
5511:
5510:
5503:Stretch-activated
5480:Ion channel class
5457:
5456:
5453:
5452:
4642:
4641:
4638:
4637:
3914:Calcium-activated
3902:Potassium channel
3888:
3887:
3884:
3883:
3676:
3675:
3672:
3671:
3258:www.genenames.org
3181:978-0-07-162442-8
2618:Neuropharmacology
2367:978-0-87893-697-7
2175:
2174:
1891:selective agonist
1667:
1666:
1463:, KA1, KA-1, EAA1
1269:potassium channel
1249:
1248:
862:
861:
341:hyperpolarization
285:, are a group of
263:
213:
212:
209:
208:
204:structure summary
7073:
7041:Protein families
7026:Membrane biology
6967:Enzyme cofactors
6886:Opioid modulator
6843:Cannabinoidergic
6709:
6708:
6515:
6514:
6502:
6501:
6456:
6455:
6318:
6311:
6304:
6295:
6294:
6230:
6229:
6042:
6041:
5586:
5585:
5558:
5551:
5544:
5535:
5534:
5476:
5475:
5463:
5462:
4671:Chloride channel
4661:
4660:
4648:
4647:
4041:Inward-rectifier
3910:
3909:
3894:
3893:
3698:
3697:
3682:
3681:
3652:Two-pore channel
3355:
3354:
3339:
3338:
3315:
3308:
3301:
3292:
3291:
3249:
3219:
3218:
3190:
3184:
3173:
3167:
3166:
3138:
3132:
3126:
3120:
3119:
3083:
3077:
3076:
3058:
3040:
3031:
3025:
3024:
3014:
2990:
2984:
2983:
2973:
2956:(10): 1278–303.
2941:
2935:
2934:
2898:
2892:
2891:
2871:
2865:
2864:
2828:
2822:
2821:
2811:
2779:
2773:
2772:
2750:
2744:
2743:
2707:
2701:
2700:
2690:
2658:
2652:
2651:
2641:
2609:
2596:
2595:
2585:
2575:
2551:
2540:
2539:
2529:
2505:
2499:
2498:
2488:
2478:
2446:
2440:
2439:
2429:
2419:
2395:
2386:
2385:
2379:
2371:
2353:
2347:
2336:
2330:
2329:
2322:
2267:Action potential
2261:
2256:
2255:
2036:
2035:
1282:
1281:
1262:neurotransmitter
869:
868:
493:
492:
440:action potential
372:channel blockers
325:neurotransmitter
314:neurotransmitter
264:
152:
151:
38:
26:
25:
7081:
7080:
7076:
7075:
7074:
7072:
7071:
7070:
6996:
6995:
6994:
6985:
6946:
6936:
6905:
6872:
6837:
6774:
6736:
6694:
6683:
6657:
6652:
6644:
6636:
6610:
6581:
6495:
6486:
6471:
6447:
6393:Inverse agonist
6383:Partial agonist
6327:
6322:
6292:
6283:
6211:
6205:
6197:
6175:
6110:
6024:
6006:
6001:
5993:- Ganglion type
5992:
5988:
5980:
5972:
5968:
5960:
5956:
5856:
5847:
5839:
5831:
5823:
5806:
5800:
5792:
5784:
5775:
5745:
5737:
5729:
5721:
5713:
5705:
5697:
5689:
5681:
5673:
5665:
5657:
5649:
5632:
5601:
5575:
5562:
5532:
5527:
5507:
5470:
5449:
5298:
5197:
5187:
4983:
4881:
4857:
4655:
4634:
4548:
4425:
4282:
4265:
4170:
4134:
4104:
4060:
4052:
4035:
3989:
3904:
3880:
3853:
3792:
3775:
3734:
3692:
3668:
3551:
3523:
3510:
3497:
3477:
3464:
3429:
3408:
3349:
3347:Calcium channel
3333:
3319:
3240:
3227:
3222:
3191:
3187:
3174:
3170:
3139:
3135:
3127:
3123:
3088:Nature Medicine
3084:
3080:
3049:(14): 1454–62.
3038:
3032:
3028:
2991:
2987:
2942:
2938:
2899:
2895:
2872:
2868:
2829:
2825:
2780:
2776:
2765:
2751:
2747:
2708:
2704:
2659:
2655:
2610:
2599:
2552:
2543:
2520:(19): 19383–6.
2506:
2502:
2461:(3): e0151934.
2447:
2443:
2396:
2389:
2373:
2372:
2368:
2354:
2350:
2337:
2333:
2324:
2323:
2319:
2315:
2257:
2250:
2247:
2180:
2171:
2167:
2166:
2162:
2161:
2157:
2156:
2152:
2151:
2147:
2146:
2142:
2141:
2130:
2124:
2118:
2112:
2106:
2100:
2089:
2085:
2081:
2077:
2073:
2069:
2053:Previous names
2046:
2024:
2010:
1950:; L-aspartate;
1844:
1765:Quisqualic acid
1686:(also known as
1672:
1663:
1661:
1652:
1641:
1626:
1622:
1620:
1609:
1598:
1589:
1585:
1583:
1579:
1577:
1573:
1571:
1560:
1554:
1548:
1537:
1533:
1529:
1521:
1520:
1519:
1517:
1506:
1500:
1489:
1485:
1468:
1464:
1462:
1458:
1456:
1452:
1450:
1446:
1444:
1433:
1427:
1421:
1415:
1404:
1400:
1396:
1392:
1375:
1371:
1369:
1365:
1363:
1359:
1357:
1346:
1340:
1334:
1323:
1319:
1315:
1299:Previous names
1292:
1254:
1226:
1225:
1216:
1210:
1204:
1193:
1189:
1185:
1175:
1167:
1156:
1150:
1139:
1135:
1040:
1034:
1026:
1022:
1018:
1006:
1005:
997:
991:
980:
976:
965:
956:
950:
944:
938:
932:
921:
917:
913:
909:
905:
896:
886:Previous names
879:
867:
842:
774:
773:
771:
762:
756:
750:
739:
735:
731:
720:
719:
718:
717:
716:
715:
714:
713:
704:
698:
692:
686:
680:
674:
668:
662:
651:
647:
643:
639:
635:
631:
627:
623:
613:
605:
601:
600:
596:
595:
591:
590:
586:
585:
574:
568:
562:
556:
545:
541:
537:
533:
526:
518:
510:Previous names
503:
491:
471:
400:
357:presynaptically
253:
240:
128:OPM superfamily
41:
24:
17:
12:
11:
5:
7079:
7069:
7068:
7063:
7058:
7053:
7048:
7043:
7038:
7036:Neurochemistry
7033:
7028:
7023:
7018:
7013:
7008:
6991:
6990:
6987:
6986:
6984:
6983:
6971:
6958:
6956:
6952:
6951:
6948:
6947:
6945:
6944:
6939:
6934:
6930:
6925:
6920:
6913:
6911:
6907:
6906:
6904:
6903:
6898:
6893:
6888:
6882:
6880:
6874:
6873:
6871:
6870:
6864:
6858:
6853:
6847:
6845:
6839:
6838:
6836:
6835:
6829:
6820:
6811:
6810:
6809:
6798:
6788:
6786:
6780:
6779:
6776:
6775:
6773:
6772:
6767:
6757:
6746:
6744:
6738:
6737:
6735:
6734:
6728:
6723:
6717:
6715:
6706:
6700:
6699:
6696:
6695:
6693:
6692:
6686:
6681:
6673:
6667:
6665:
6659:
6658:
6656:
6655:
6650:
6646:
6642:
6638:
6634:
6626:
6620:
6618:
6612:
6611:
6609:
6608:
6602:
6597:
6591:
6589:
6583:
6582:
6580:
6579:
6573:
6567:
6561:
6548:
6542:
6533:
6523:
6521:
6512:
6499:
6488:
6487:
6481:
6479:
6473:
6472:
6464:
6462:
6453:
6449:
6448:
6446:
6445:
6440:
6433:
6432:
6426:
6420:
6408:
6407:
6401:
6395:
6390:
6385:
6380:
6369:
6368:
6363:
6352:
6351:
6346:
6335:
6333:
6329:
6328:
6321:
6320:
6313:
6306:
6298:
6289:
6288:
6285:
6284:
6282:
6281:
6280:
6279:
6274:
6269:
6264:
6259:
6254:
6249:
6238:
6236:
6227:
6225:gated channels
6217:
6216:
6213:
6212:
6210:
6209:
6208:
6207:
6203:
6199:
6195:
6185:
6183:
6177:
6176:
6174:
6173:
6172:
6171:
6166:
6161:
6156:
6151:
6146:
6141:
6136:
6131:
6120:
6118:
6112:
6111:
6109:
6108:
6107:
6106:
6101:
6096:
6091:
6086:
6076:
6070:
6065:
6060:
6050:
6048:
6039:
6030:
6029:
6026:
6025:
6023:
6022:
6020:Zinc-activated
6016:
6014:
6008:
6007:
6005:
6004:
5999:
5995:
5990:
5986:
5982:
5978:
5974:
5970:
5966:
5962:
5958:
5954:
5946:
5945:
5940:
5935:
5930:
5925:
5920:
5915:
5910:
5905:
5900:
5895:
5890:
5885:
5880:
5875:
5866:
5864:
5858:
5857:
5855:
5854:
5849:
5845:
5841:
5837:
5833:
5829:
5825:
5821:
5816:
5814:
5808:
5807:
5805:
5804:
5803:
5802:
5798:
5794:
5790:
5786:
5782:
5773:
5769:
5768:
5767:
5762:
5757:
5752:
5747:
5743:
5739:
5735:
5731:
5727:
5723:
5719:
5715:
5711:
5707:
5703:
5699:
5695:
5691:
5687:
5683:
5679:
5675:
5671:
5667:
5663:
5659:
5655:
5647:
5642:
5640:
5634:
5633:
5631:
5630:
5629:
5628:
5623:
5618:
5613:
5608:
5599:
5594:
5592:
5590:5-HT/serotonin
5583:
5577:
5576:
5561:
5560:
5553:
5546:
5538:
5529:
5528:
5520:
5517:
5516:
5513:
5512:
5509:
5508:
5506:
5505:
5500:
5495:
5490:
5484:
5482:
5472:
5471:
5459:
5458:
5455:
5454:
5451:
5450:
5448:
5447:
5442:
5441:
5440:
5439:
5438:
5433:
5428:
5420:
5419:
5418:
5413:
5408:
5400:
5399:
5398:
5393:
5388:
5383:
5378:
5373:
5368:
5360:
5359:
5358:
5353:
5348:
5343:
5338:
5333:
5328:
5314:
5312:
5300:
5299:
5297:
5296:
5291:
5290:
5289:
5284:
5279:
5269:
5268:
5267:
5262:
5257:
5252:
5247:
5242:
5237:
5232:
5227:
5222:
5211:
5209:
5195:
5189:
5188:
5186:
5185:
5184:
5183:
5178:
5173:
5168:
5163:
5158:
5148:
5147:
5146:
5141:
5131:
5126:
5125:
5124:
5119:
5114:
5104:
5103:
5102:
5097:
5092:
5087:
5082:
5077:
5072:
5067:
5057:
5056:
5055:
5050:
5045:
5040:
5035:
5030:
5025:
5020:
5010:
4999:
4997:
4985:
4984:
4982:
4981:
4980:
4979:
4974:
4969:
4964:
4959:
4947:
4946:
4945:
4940:
4935:
4925:
4924:
4923:
4918:
4913:
4908:
4897:
4895:
4883:
4882:
4880:
4879:
4873:
4871:
4869:Proton channel
4859:
4858:
4856:
4855:
4854:
4853:
4848:
4838:
4837:
4836:
4831:
4826:
4821:
4816:
4811:
4806:
4796:
4795:
4794:
4789:
4784:
4779:
4774:
4769:
4764:
4759:
4754:
4744:
4739:
4738:
4737:
4736:
4735:
4730:
4725:
4720:
4710:
4709:
4708:
4703:
4693:
4692:
4691:
4675:
4673:
4657:
4656:
4644:
4643:
4640:
4639:
4636:
4635:
4633:
4632:
4627:
4626:
4625:
4620:
4615:
4605:
4600:
4595:
4594:
4593:
4588:
4583:
4578:
4568:
4567:
4566:
4561:
4556:
4546:
4541:
4540:
4539:
4538:
4533:
4528:
4521:
4520:
4519:
4514:
4509:
4502:
4501:
4500:
4495:
4488:
4487:
4486:
4481:
4476:
4469:
4468:
4467:
4462:
4455:
4454:
4453:
4448:
4443:
4438:
4433:
4423:
4418:
4417:
4416:
4415:
4410:
4405:
4400:
4393:
4392:
4391:
4384:
4383:
4382:
4377:
4372:
4365:
4364:
4363:
4358:
4353:
4348:
4341:
4340:
4339:
4334:
4327:
4326:
4325:
4320:
4315:
4310:
4305:
4300:
4295:
4290:
4280:
4275:
4273:
4267:
4266:
4264:
4263:
4262:
4261:
4256:
4251:
4246:
4241:
4236:
4231:
4226:
4221:
4216:
4211:
4206:
4201:
4196:
4191:
4180:
4178:
4172:
4171:
4169:
4168:
4167:
4166:
4161:
4156:
4151:
4146:
4141:
4132:
4128:
4127:
4126:
4121:
4116:
4111:
4102:
4094:
4093:
4092:
4087:
4082:
4077:
4072:
4067:
4058:
4054:
4050:
4045:
4043:
4037:
4036:
4034:
4033:
4032:
4031:
4026:
4021:
4016:
4011:
4006:
4001:
3996:
3987:
3983:
3982:
3981:
3973:
3972:
3971:
3966:
3961:
3951:
3950:
3949:
3944:
3939:
3934:
3929:
3918:
3916:
3906:
3905:
3890:
3889:
3886:
3885:
3882:
3881:
3879:
3878:
3877:
3876:
3871:
3866:
3861:
3851:
3847:
3846:
3845:
3840:
3835:
3830:
3825:
3820:
3815:
3810:
3805:
3800:
3790:
3785:
3783:
3777:
3776:
3774:
3773:
3772:
3771:
3766:
3761:
3756:
3745:
3743:
3736:
3735:
3733:
3732:
3731:
3730:
3725:
3720:
3715:
3704:
3702:
3694:
3693:
3690:Sodium channel
3678:
3677:
3674:
3673:
3670:
3669:
3667:
3666:
3665:
3664:
3659:
3649:
3648:
3647:
3642:
3637:
3632:
3621:
3620:
3619:
3618:
3613:
3608:
3603:
3593:
3592:
3591:
3586:
3581:
3576:
3566:
3565:
3564:
3559:
3549:
3544:
3543:
3542:
3541:
3536:
3531:
3521:
3513:
3508:
3500:
3495:
3487:
3486:
3485:
3475:
3467:
3462:
3454:
3453:
3452:
3447:
3442:
3437:
3427:
3418:
3416:
3410:
3409:
3407:
3406:
3405:
3404:
3399:
3394:
3384:
3383:
3382:
3377:
3372:
3361:
3359:
3351:
3350:
3335:
3334:
3318:
3317:
3310:
3303:
3295:
3266:
3265:
3260:
3255:
3250:
3238:
3226:
3225:External links
3223:
3221:
3220:
3201:(Suppl 1): 1.
3185:
3168:
3149:(Suppl 1): 1.
3133:
3121:
3078:
3026:
2985:
2936:
2909:(5): 1648–54.
2893:
2866:
2839:(6): 1815–22.
2823:
2774:
2763:
2745:
2702:
2653:
2597:
2541:
2500:
2441:
2404:Genome Biology
2387:
2366:
2348:
2331:
2316:
2314:
2311:
2310:
2309:
2304:
2299:
2294:
2289:
2284:
2279:
2274:
2269:
2263:
2262:
2259:Biology portal
2246:
2243:
2179:
2176:
2173:
2172:
2169:
2164:
2159:
2154:
2149:
2144:
2139:
2136:
2093:
2064:
2061:
2055:
2054:
2051:
2048:
2047:protein name
2043:
2040:
2020:Main article:
2009:
2006:
2005:
2004:
1997:kynurenic acid
1970:
1955:
1936:
1911:AMPA receptors
1843:
1842:NMDA receptors
1840:
1839:
1838:
1816:
1794:
1779:Kynurenic acid
1768:
1734:nervous system
1671:
1668:
1665:
1664:
1658:
1645:
1636:
1633:
1629:
1628:
1624:
1618:
1615:
1602:
1592:
1591:
1587:
1581:
1575:
1569:
1566:
1541:
1523:
1522:
1515:
1512:
1493:
1480:
1477:
1471:
1470:
1466:
1460:
1454:
1448:
1442:
1439:
1408:
1387:
1384:
1378:
1377:
1373:
1367:
1361:
1355:
1352:
1327:
1310:
1307:
1301:
1300:
1297:
1294:
1293:protein name
1289:
1286:
1253:
1250:
1247:
1246:
1244:
1237:
1232:
1228:
1227:
1222:
1197:
1180:
1177:
1169:
1168:
1165:
1162:
1143:
1130:
1126:
1125:
1123:
1116:
1111:
1107:
1106:
1104:
1097:
1092:
1088:
1087:
1085:
1078:
1073:
1069:
1068:
1066:
1059:
1054:
1050:
1049:
1046:
1027:
1013:
1009:
1008:
1003:
984:
971:
967:
966:
962:
925:
900:
897:
894:
888:
887:
884:
881:
876:
873:
866:
863:
860:
859:
856:
849:
846:
844:
836:
835:
832:
825:
820:
816:
815:
812:
805:
800:
796:
795:
792:
785:
780:
776:
775:
772:EFNL3, nAChRB2
768:
743:
726:
722:
721:
710:
655:
618:
615:
607:
606:
603:
598:
593:
588:
583:
580:
549:
528:
524:
520:
512:
511:
508:
505:
504:protein name
500:
497:
490:
487:
470:
467:
399:
396:
337:depolarization
329:synaptic cleft
239:
238:
228:
223:
219:
211:
210:
207:
206:
201:
195:
194:
181:
175:
174:
164:
157:
156:
148:
147:
142:
136:
135:
130:
124:
123:
118:
112:
111:
98:
92:
91:
86:
80:
79:
74:
68:
67:
62:
56:
55:
54:Neur_chan_memb
52:
48:
47:
43:
42:
39:
31:
30:
15:
9:
6:
4:
3:
2:
7078:
7067:
7064:
7062:
7059:
7057:
7054:
7052:
7049:
7047:
7044:
7042:
7039:
7037:
7034:
7032:
7029:
7027:
7024:
7022:
7019:
7017:
7014:
7012:
7009:
7007:
7004:
7003:
7001:
6981:
6980:
6975:
6972:
6969:
6968:
6963:
6960:
6959:
6957:
6955:Miscellaneous
6953:
6943:
6940:
6938:
6931:
6929:
6926:
6924:
6921:
6918:
6915:
6914:
6912:
6908:
6902:
6899:
6897:
6894:
6892:
6889:
6887:
6884:
6883:
6881:
6879:
6875:
6868:
6865:
6862:
6859:
6857:
6854:
6852:
6849:
6848:
6846:
6844:
6840:
6833:
6830:
6828:
6824:
6821:
6819:
6815:
6812:
6808:
6805:
6804:
6802:
6799:
6797:
6793:
6790:
6789:
6787:
6785:
6781:
6771:
6768:
6765:
6761:
6758:
6755:
6751:
6748:
6747:
6745:
6743:
6742:Glutamatergic
6739:
6732:
6729:
6727:
6724:
6722:
6719:
6718:
6716:
6714:
6710:
6707:
6705:
6701:
6690:
6687:
6684:
6677:
6674:
6672:
6669:
6668:
6666:
6664:
6660:
6653:
6647:
6645:
6639:
6637:
6630:
6627:
6625:
6622:
6621:
6619:
6617:
6616:Histaminergic
6613:
6606:
6603:
6601:
6598:
6596:
6593:
6592:
6590:
6588:
6584:
6577:
6574:
6571:
6568:
6565:
6562:
6560:
6556:
6552:
6549:
6546:
6543:
6541:
6537:
6534:
6532:
6528:
6525:
6524:
6522:
6520:
6516:
6513:
6511:
6507:
6503:
6500:
6498:
6493:
6489:
6485:
6480:
6478:
6474:
6470:
6469:
6463:
6461:
6457:
6454:
6450:
6444:
6441:
6439:
6435:
6434:
6430:
6427:
6424:
6421:
6418:
6414:
6410:
6409:
6405:
6402:
6399:
6396:
6394:
6391:
6389:
6386:
6384:
6381:
6379:
6375:
6371:
6370:
6367:
6364:
6362:
6358:
6354:
6353:
6350:
6347:
6345:
6341:
6337:
6336:
6334:
6330:
6326:
6319:
6314:
6312:
6307:
6305:
6300:
6299:
6296:
6278:
6275:
6273:
6270:
6268:
6265:
6263:
6260:
6258:
6255:
6253:
6250:
6248:
6245:
6244:
6243:
6240:
6239:
6237:
6235:
6231:
6228:
6226:
6222:
6218:
6206:
6200:
6198:
6192:
6191:
6190:
6187:
6186:
6184:
6182:
6178:
6170:
6167:
6165:
6162:
6160:
6157:
6155:
6152:
6150:
6147:
6145:
6142:
6140:
6137:
6135:
6132:
6130:
6127:
6126:
6125:
6122:
6121:
6119:
6117:
6113:
6105:
6102:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6081:
6080:
6077:
6074:
6071:
6069:
6066:
6064:
6061:
6059:
6055:
6052:
6051:
6049:
6047:
6043:
6040:
6038:
6035:
6031:
6021:
6018:
6017:
6015:
6013:
6009:
6003:
5996:
5994:
5983:
5981:
5975:
5973:
5963:
5961:
5951:
5948:
5947:
5944:
5941:
5939:
5936:
5934:
5931:
5929:
5926:
5924:
5921:
5919:
5916:
5914:
5911:
5909:
5906:
5904:
5901:
5899:
5896:
5894:
5891:
5889:
5886:
5884:
5881:
5879:
5876:
5874:
5871:
5868:
5867:
5865:
5863:
5859:
5853:
5850:
5848:
5842:
5840:
5834:
5832:
5826:
5824:
5818:
5817:
5815:
5813:
5809:
5801:
5795:
5793:
5787:
5785:
5779:
5778:
5777:
5770:
5766:
5763:
5761:
5758:
5756:
5753:
5751:
5748:
5746:
5740:
5738:
5732:
5730:
5724:
5722:
5716:
5714:
5708:
5706:
5700:
5698:
5692:
5690:
5684:
5682:
5676:
5674:
5668:
5666:
5660:
5658:
5652:
5651:
5650:
5644:
5643:
5641:
5639:
5635:
5627:
5624:
5622:
5619:
5617:
5614:
5612:
5609:
5607:
5604:
5603:
5602:
5596:
5595:
5593:
5591:
5587:
5584:
5582:
5578:
5574:
5570:
5566:
5559:
5554:
5552:
5547:
5545:
5540:
5539:
5536:
5526:
5525:
5518:
5504:
5501:
5499:
5498:Voltage-gated
5496:
5494:
5491:
5489:
5486:
5485:
5483:
5481:
5477:
5473:
5469:
5464:
5460:
5446:
5443:
5437:
5434:
5432:
5429:
5427:
5424:
5423:
5421:
5417:
5414:
5412:
5409:
5407:
5404:
5403:
5401:
5397:
5394:
5392:
5389:
5387:
5384:
5382:
5379:
5377:
5374:
5372:
5369:
5367:
5364:
5363:
5361:
5357:
5354:
5352:
5349:
5347:
5344:
5342:
5339:
5337:
5334:
5332:
5329:
5327:
5324:
5323:
5321:
5320:
5319:
5316:
5315:
5313:
5311:
5308:
5306:
5301:
5295:
5292:
5288:
5285:
5283:
5280:
5278:
5275:
5274:
5273:
5270:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5241:
5238:
5236:
5233:
5231:
5228:
5226:
5223:
5221:
5218:
5217:
5216:
5213:
5212:
5210:
5208:
5205:
5203:
5199:
5190:
5182:
5179:
5177:
5174:
5172:
5169:
5167:
5164:
5162:
5159:
5157:
5154:
5153:
5152:
5149:
5145:
5142:
5140:
5137:
5136:
5135:
5132:
5130:
5127:
5123:
5120:
5118:
5115:
5113:
5110:
5109:
5108:
5105:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5062:
5061:
5058:
5054:
5051:
5049:
5046:
5044:
5041:
5039:
5036:
5034:
5031:
5029:
5026:
5024:
5021:
5019:
5016:
5015:
5014:
5011:
5008:
5004:
5001:
5000:
4998:
4996:
4993:
4991:
4986:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4954:
4953:
4952:
4948:
4944:
4941:
4939:
4936:
4934:
4931:
4930:
4929:
4926:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4903:
4902:
4899:
4898:
4896:
4894:
4891:
4889:
4884:
4878:
4875:
4874:
4872:
4870:
4867:
4865:
4860:
4852:
4849:
4847:
4844:
4843:
4842:
4839:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4815:
4812:
4810:
4807:
4805:
4802:
4801:
4800:
4797:
4793:
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4749:
4748:
4745:
4743:
4740:
4734:
4731:
4729:
4726:
4724:
4721:
4719:
4716:
4715:
4714:
4711:
4707:
4704:
4702:
4699:
4698:
4697:
4694:
4690:
4687:
4686:
4685:
4682:
4681:
4680:
4677:
4676:
4674:
4672:
4669:
4667:
4662:
4658:
4654:
4653:Miscellaneous
4649:
4645:
4631:
4630:Shaker (gene)
4628:
4624:
4621:
4619:
4616:
4614:
4611:
4610:
4609:
4606:
4604:
4603:minK/ISK-like
4601:
4599:
4596:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4573:
4572:
4569:
4565:
4562:
4560:
4557:
4555:
4552:
4551:
4550:
4543:
4542:
4537:
4534:
4532:
4529:
4527:
4524:
4523:
4522:
4518:
4515:
4513:
4510:
4508:
4505:
4504:
4503:
4499:
4496:
4494:
4491:
4490:
4489:
4485:
4482:
4480:
4477:
4475:
4472:
4471:
4470:
4466:
4463:
4461:
4458:
4457:
4456:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4428:
4427:
4420:
4419:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4395:
4394:
4390:
4387:
4386:
4385:
4381:
4378:
4376:
4373:
4371:
4368:
4367:
4366:
4362:
4359:
4357:
4354:
4352:
4349:
4347:
4344:
4343:
4342:
4338:
4335:
4333:
4330:
4329:
4328:
4324:
4321:
4319:
4316:
4314:
4311:
4309:
4306:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4285:
4284:
4277:
4276:
4274:
4272:
4271:Voltage-gated
4268:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4217:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
4186:
4185:
4182:
4181:
4179:
4177:
4173:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4140:
4137:
4136:
4135:
4129:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4106:
4105:
4098:
4095:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4062:
4061:
4055:
4053:
4047:
4046:
4044:
4042:
4038:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4012:
4010:
4007:
4005:
4002:
4000:
3997:
3995:
3992:
3991:
3990:
3984:
3980:
3977:
3976:
3974:
3970:
3967:
3965:
3962:
3960:
3957:
3956:
3955:
3952:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3928:
3925:
3924:
3923:
3920:
3919:
3917:
3915:
3911:
3907:
3903:
3900:
3895:
3891:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3856:
3855:
3848:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3795:
3794:
3787:
3786:
3784:
3782:
3781:Voltage-gated
3778:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3751:
3750:
3747:
3746:
3744:
3741:
3737:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3710:
3709:
3706:
3705:
3703:
3699:
3695:
3691:
3688:
3683:
3679:
3663:
3660:
3658:
3655:
3654:
3653:
3650:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3627:
3626:
3623:
3622:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3598:
3597:
3594:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3571:
3570:
3567:
3563:
3560:
3558:
3555:
3554:
3553:
3546:
3545:
3540:
3537:
3535:
3532:
3530:
3527:
3526:
3525:
3517:
3514:
3512:
3504:
3501:
3499:
3491:
3488:
3484:
3481:
3480:
3479:
3471:
3468:
3466:
3458:
3455:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3432:
3431:
3423:
3420:
3419:
3417:
3415:
3414:Voltage-gated
3411:
3403:
3400:
3398:
3395:
3393:
3390:
3389:
3388:
3385:
3381:
3378:
3376:
3373:
3371:
3368:
3367:
3366:
3363:
3362:
3360:
3356:
3352:
3348:
3345:
3340:
3336:
3331:
3327:
3323:
3316:
3311:
3309:
3304:
3302:
3297:
3296:
3293:
3289:
3288:
3286:
3282:
3277:
3274:
3272:
3264:
3261:
3259:
3256:
3254:
3251:
3247:
3243:
3239:
3236:
3232:
3229:
3228:
3216:
3212:
3208:
3204:
3200:
3196:
3189:
3182:
3178:
3172:
3164:
3160:
3156:
3152:
3148:
3144:
3137:
3131:
3125:
3117:
3113:
3109:
3105:
3101:
3097:
3093:
3089:
3082:
3074:
3070:
3066:
3062:
3057:
3052:
3048:
3044:
3043:FASEB Journal
3037:
3030:
3022:
3018:
3013:
3008:
3004:
3000:
2996:
2989:
2981:
2977:
2972:
2967:
2963:
2959:
2955:
2951:
2947:
2940:
2932:
2928:
2924:
2920:
2916:
2912:
2908:
2904:
2897:
2889:
2885:
2881:
2877:
2870:
2862:
2858:
2854:
2850:
2846:
2842:
2838:
2834:
2827:
2819:
2815:
2810:
2805:
2801:
2797:
2793:
2789:
2785:
2778:
2771:
2766:
2764:9780071481274
2760:
2756:
2749:
2741:
2737:
2733:
2729:
2725:
2721:
2717:
2713:
2706:
2698:
2694:
2689:
2684:
2680:
2676:
2673:(3): 243–60.
2672:
2668:
2664:
2657:
2649:
2645:
2640:
2635:
2631:
2627:
2623:
2619:
2615:
2608:
2606:
2604:
2602:
2593:
2589:
2584:
2579:
2574:
2569:
2565:
2561:
2557:
2550:
2548:
2546:
2537:
2533:
2528:
2523:
2519:
2515:
2511:
2504:
2496:
2492:
2487:
2482:
2477:
2472:
2468:
2464:
2460:
2456:
2452:
2445:
2437:
2433:
2428:
2423:
2418:
2413:
2409:
2405:
2401:
2394:
2392:
2383:
2377:
2369:
2363:
2359:
2352:
2346:
2345:
2340:
2335:
2327:
2321:
2317:
2308:
2305:
2303:
2300:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2273:
2270:
2268:
2265:
2264:
2260:
2254:
2249:
2242:
2240:
2236:
2232:
2228:
2224:
2220:
2216:
2212:
2206:
2204:
2200:
2196:
2192:
2188:
2184:
2137:
2135:
2134:
2129:
2128:
2123:
2122:
2117:
2116:
2111:
2110:
2105:
2104:
2099:
2098:
2094:
2092:
2088:
2084:
2080:
2076:
2072:
2068:
2065:
2062:
2060:
2057:
2056:
2052:
2049:
2044:
2041:
2038:
2037:
2034:
2032:
2029:
2023:
2014:
2002:
1998:
1994:
1990:
1986:
1982:
1978:
1974:
1971:
1968:
1964:
1960:
1956:
1953:
1949:
1948:D-cycloserine
1945:
1941:
1937:
1935:
1931:
1927:
1923:
1920:
1916:
1915:
1914:
1912:
1908:
1907:binding sites
1904:
1900:
1896:
1892:
1888:
1883:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1856:NMDA receptor
1848:
1836:
1832:
1828:
1824:
1820:
1817:
1814:
1810:
1806:
1805:Cyclothiazide
1802:
1798:
1795:
1792:
1788:
1784:
1780:
1776:
1772:
1769:
1766:
1762:
1758:
1754:
1750:
1746:
1743:
1742:
1741:
1739:
1735:
1731:
1726:
1722:
1718:
1714:
1710:
1706:
1703:
1699:
1695:
1691:
1690:
1689:AMPA receptor
1685:
1676:
1670:AMPA receptor
1659:
1657:
1656:
1651:
1650:
1646:
1644:
1640:
1637:
1630:
1616:
1614:
1613:
1608:
1607:
1603:
1601:
1597:
1594:
1593:
1567:
1565:
1564:
1559:
1558:
1553:
1552:
1547:
1546:
1542:
1540:
1536:
1532:
1528:
1525:
1524:
1513:
1511:
1510:
1505:
1504:
1499:
1498:
1494:
1492:
1488:
1484:
1481:
1476:
1472:
1440:
1438:
1437:
1432:
1431:
1426:
1425:
1420:
1419:
1414:
1413:
1409:
1407:
1403:
1399:
1395:
1391:
1388:
1385:
1383:
1380:
1379:
1353:
1351:
1350:
1345:
1344:
1339:
1338:
1333:
1332:
1328:
1326:
1322:
1318:
1314:
1311:
1308:
1306:
1303:
1302:
1298:
1295:
1290:
1287:
1284:
1283:
1276:
1272:
1270:
1266:
1263:
1259:
1245:
1243:
1242:
1238:
1236:
1233:
1230:
1229:
1223:
1221:
1220:
1215:
1214:
1209:
1208:
1203:
1202:
1198:
1196:
1192:
1188:
1184:
1181:
1178:
1174:
1170:
1163:
1161:
1160:
1155:
1154:
1149:
1148:
1144:
1142:
1138:
1134:
1131:
1128:
1127:
1124:
1122:
1121:
1117:
1115:
1112:
1109:
1108:
1105:
1103:
1102:
1098:
1096:
1093:
1090:
1089:
1086:
1084:
1083:
1079:
1077:
1074:
1071:
1070:
1067:
1065:
1064:
1060:
1058:
1055:
1052:
1051:
1047:
1045:
1044:
1039:
1038:
1033:
1032:
1028:
1025:
1021:
1017:
1014:
1011:
1010:
1004:
1002:
1001:
996:
995:
990:
989:
985:
983:
979:
975:
972:
969:
968:
963:
961:
960:
955:
954:
949:
948:
943:
942:
937:
936:
931:
930:
926:
924:
920:
916:
912:
908:
904:
901:
898:
893:
889:
885:
882:
880:protein name
877:
874:
871:
870:
857:
855:
854:
850:
847:
845:
841:
838:
837:
833:
831:
830:
826:
824:
821:
818:
817:
813:
811:
810:
806:
804:
801:
798:
797:
793:
791:
790:
786:
784:
781:
778:
777:
769:
767:
766:
761:
760:
755:
754:
749:
748:
744:
742:
738:
734:
730:
727:
724:
723:
711:
709:
708:
703:
702:
697:
696:
691:
690:
685:
684:
679:
678:
673:
672:
667:
666:
661:
660:
656:
654:
650:
646:
642:
638:
634:
630:
626:
622:
619:
616:
612:
608:
581:
579:
578:
573:
572:
567:
566:
561:
560:
555:
554:
550:
548:
544:
540:
536:
532:
529:
527:
521:
517:
514:
513:
509:
506:
501:
498:
495:
494:
486:
484:
480:
476:
466:
464:
460:
456:
452:
448:
443:
441:
437:
433:
432:acetylcholine
429:
424:
422:
417:
413:
404:
395:
393:
389:
385:
381:
377:
373:
369:
366:
362:
358:
354:
350:
344:
342:
338:
334:
330:
326:
322:
317:
315:
312:), such as a
311:
307:
303:
299:
295:
291:
288:
287:transmembrane
284:
280:
276:
272:
248:
247:cell membrane
244:
236:
235:acetylcholine
232:
229:
227:
224:
221:
220:
217:
205:
202:
200:
196:
193:
189:
185:
182:
180:
176:
172:
168:
165:
162:
158:
153:
149:
146:
143:
141:
137:
134:
131:
129:
125:
122:
119:
117:
113:
110:
106:
102:
99:
97:
93:
90:
87:
85:
81:
78:
75:
73:
69:
66:
63:
61:
57:
53:
49:
44:
37:
32:
27:
22:
7016:Ion channels
7006:Cell biology
6977:
6965:
6663:Serotonergic
6587:Dopaminergic
6466:
6224:
6188:
6180:
6115:
6045:
6033:
6011:
5949:
5869:
5572:
5521:
5488:Ligand-gated
5487:
5479:
5467:
5310:Gap junction
5303:
5192:
4988:
4949:
4927:
4900:
4886:
4862:
4840:
4798:
4746:
4712:
4695:
4683:
4664:
4652:
4607:
4570:
4544:
4421:
4278:
4183:
4130:
4100:
4056:
3985:
3898:
3849:
3788:
3686:
3595:
3568:
3547:
3519:
3506:
3493:
3473:
3460:
3425:
3358:Ligand-gated
3343:
3326:ion channels
3278:
3268:
3267:
3245:
3198:
3194:
3188:
3171:
3146:
3142:
3136:
3124:
3094:(7): 780–4.
3091:
3087:
3081:
3046:
3042:
3029:
3005:(1): 41–51.
3002:
2998:
2988:
2953:
2949:
2939:
2906:
2902:
2896:
2879:
2875:
2869:
2836:
2832:
2826:
2794:(3): 302–3.
2791:
2787:
2777:
2768:
2754:
2748:
2718:(1): 173–8.
2715:
2711:
2705:
2670:
2666:
2656:
2621:
2617:
2563:
2559:
2517:
2513:
2503:
2458:
2454:
2444:
2407:
2403:
2357:
2351:
2342:
2334:
2320:
2235:serotonergic
2231:melatonergic
2207:
2182:
2181:
2131:
2125:
2119:
2113:
2107:
2101:
2095:
2025:
2022:P2X receptor
1989:ketobemidone
1884:
1882:and memory.
1853:
1738:crystallized
1693:
1687:
1683:
1681:
1653:
1647:
1610:
1604:
1561:
1555:
1549:
1543:
1507:
1501:
1495:
1434:
1428:
1422:
1416:
1410:
1347:
1341:
1335:
1329:
1255:
1239:
1217:
1211:
1205:
1199:
1157:
1151:
1145:
1118:
1099:
1080:
1061:
1041:
1035:
1029:
998:
992:
986:
957:
951:
945:
939:
933:
927:
851:
827:
807:
787:
763:
757:
751:
745:
705:
699:
693:
687:
681:
675:
669:
663:
657:
575:
569:
563:
557:
551:
472:
462:
458:
457:igand-gated
454:
450:
444:
425:
409:
361:postsynaptic
345:
318:
282:
278:
274:
270:
269:
6979:Amino acids
6878:Opioidergic
6784:Cholinergic
6497:transporter
6477:Ion channel
6413:Transporter
6357:Ion channel
5565:Ion channel
5493:Light-gated
3975:IK channel
3253:www.esf.edu
2882:(1): 7–61.
2227:Agomelatine
2203:anaesthetic
2189:agents and
2187:anaesthetic
1973:Antagonists
1952:quinolinate
1928:and either
1922:co-agonists
1835:GYKI-52,466
1771:Antagonists
1761:Domoic acid
1725:quisqualate
1696:) is a non-
1627:, NMDA-R3B
485:formation.
453:loeobacter
290:ion-channel
243:ion channel
140:OPM protein
46:Identifiers
7000:Categories
6827:Ganglionic
6818:Muscarinic
6796:Muscarinic
6519:Adrenergic
6388:Antagonist
6037:glutamates
6034:Ionotropic
5950:pentamers:
4696:Bestrophin
3954:SK channel
3922:BK channel
3596:γ-subunits
3569:β-subunits
3552:δ-subunits
3039:(abstract)
2624:(1): 2–5.
2313:References
2028:nucleotide
2001:endogenous
1919:endogenous
1831:Talampanel
1827:Perampanel
1801:Aniracetam
1787:Perampanel
1702:ionotropic
365:allosteric
349:allosteric
167:structures
6974:Precursor
6823:Nicotinic
6801:Nicotinic
6713:GABAergic
6438:Precursor
6423:Inhibitor
6349:Inhibitor
5870:monomers:
5524:disorders
5522:see also
5305:Cytoplasm
5215:Aquaporin
4684:Anoctamin
4507:11.1/hERG
3271:this edit
3215:145014277
3163:144761669
2410:(1): R4.
2376:cite book
2215:Memantine
1926:glutamate
1868:glutamate
1791:Piracetam
1749:Glutamate
1709:glutamate
1632:‘Orphan’
1265:glutamate
1260:bind the
964:EJM, ECA4
516:Serotonin
469:Structure
378:, or the
304:, and/or
233:(such as
89:PDOC00209
77:IPR006029
21:inotropic
6962:Cofactor
6832:Muscular
6492:Receptor
6443:Cofactor
6429:Releaser
6417:Enhancer
6411:♦
6374:Receptor
6372:♦
6355:♦
6338:♦
6181:‘Orphan’
5318:Connexin
4598:minK/ISK
3116:31877708
3108:16829947
3073:17913232
3021:12173240
2980:10487207
2931:11672391
2923:15687225
2888:10049997
2861:15442694
2853:17432968
2818:19605837
2740:42753770
2697:18790874
2648:18655795
2592:27330534
2536:15023997
2495:26986966
2455:PLOS ONE
2436:15642096
2245:See also
1993:tramadol
1977:ketamine
1967:NRX-1074
1942: :
1940:agonists
1930:D-serine
1917:Primary
1872:D-serine
1745:Agonists
1713:synaptic
1072:epsilon
819:epsilon
614:(nAChR)
465:hannel.
416:cysteine
353:synapses
184:RCSB PDB
72:InterPro
6919:(AdoRI)
6869:(eCBRI)
6452:Classes
6378:Agonist
6366:Blocker
6344:Inducer
6079:Kainate
5812:Glycine
5445:Innexin
5202:solutes
3065:7589987
2971:2854026
2809:3703758
2732:6125564
2688:2847512
2639:2847504
2583:4891346
2486:4795631
2463:Bibcode
2191:ethanol
2003:), etc.
1934:glycine
1876:glycine
1823:Ethanol
1635:(GluD)
1509:GRINL1B
1503:GRINL1A
1382:Kainate
1176:(GlyR)
1173:Glycine
707:CHRNA10
519:(5-HT)
483:synapse
421:helices
368:ligands
319:When a
84:PROSITE
65:PF02932
6863:(eCBE)
6460:Enzyme
6361:Opener
6340:Enzyme
3742:-gated
3740:Proton
3516:T-type
3503:R-type
3490:Q-type
3470:P-type
3457:N-type
3422:L-type
3269:As of
3213:
3179:
3161:
3114:
3106:
3071:
3063:
3019:
2978:
2968:
2929:
2921:
2886:
2859:
2851:
2816:
2806:
2761:
2738:
2730:
2695:
2685:
2646:
2636:
2590:
2580:
2566:: 41.
2534:
2493:
2483:
2434:
2427:549065
2424:
2364:
2042:Class
1954:, etc.
1938:Other
1895:cation
1837:, etc.
1815:, etc.
1813:CX-614
1809:CX-516
1793:, etc.
1767:, etc.
1700:-type
1662:GluRδ2
1660:GluRδ1
1612:GRIN3B
1606:GRIN3A
1600:GluN3B
1596:GluN3A
1563:GRIN2D
1557:GRIN2C
1551:GRIN2B
1545:GRIN2A
1539:GluN2D
1535:GluN2C
1531:GluN2B
1527:GluN2A
1288:Class
1179:alpha
1159:GABRR3
1153:GABRR2
1147:GABRR1
1110:theta
1053:delta
1043:GABRG3
1037:GABRG2
1031:GABRG1
1012:gamma
1000:GABRB3
994:GABRB2
988:GABRB1
959:GABRA6
953:GABRA5
947:GABRA4
941:GABRA3
935:GABRA2
929:GABRA1
899:alpha
875:Class
843:(ZAC)
799:delta
794:ACHRG
779:gamma
765:CHRNB4
759:CHRNB3
753:CHRNB2
747:CHRNB1
701:CHRNA9
695:CHRNA7
689:CHRNA6
683:CHRNA5
677:CHRNA4
671:CHRNA3
665:CHRNA2
659:CHRNA1
617:alpha
547:5-HT3E
543:5-HT3D
539:5-HT3C
535:5-HT3B
531:5-HT3A
499:Class
310:ligand
231:Ligand
199:PDBsum
173:
163:
109:SUPFAM
51:Symbol
6976:(see
6964:(see
6910:Other
6733:(GRI)
6691:(SRI)
6607:(DRI)
6578:(NRI)
6494:&
6406:(NAM)
6400:(PAM)
6332:Types
5356:GJA10
5207:Porin
5107:TRPML
4877:HVCN1
4571:KCNIP
4426:α7-12
3330:TC 1A
3211:S2CID
3159:S2CID
3112:S2CID
3069:S2CID
2927:S2CID
2857:S2CID
2736:S2CID
2133:P2RX7
2127:P2RX6
2121:P2RX5
2115:P2RX4
2109:P2RX3
2103:P2RX2
2097:P2RX1
2050:Gene
2039:Type
1864:gated
1730:brain
1692:, or
1655:GRID2
1649:GRID1
1643:GluD2
1639:GluD1
1497:GRIN1
1491:NRL1B
1487:NRL1A
1483:GluN1
1479:GluN
1436:GRIK5
1430:GRIK4
1424:GRIK3
1418:GRIK2
1412:GRIK1
1406:GluK5
1402:GluK4
1398:GluK3
1394:GluK2
1390:GluK1
1386:GluK
1349:GRIA4
1343:GRIA3
1337:GRIA2
1331:GRIA1
1325:GluA4
1321:GluA3
1317:GluA2
1313:GluA1
1309:GluA
1296:Gene
1285:Type
1231:beta
1224:STHE
1219:GLRA4
1213:GLRA3
1207:GLRA2
1201:GLRA1
1120:GABRQ
1101:GABRP
1082:GABRE
1063:GABRD
1007:ECA5
970:beta
883:Gene
872:Type
829:CHRNE
809:CHRND
789:CHRNG
725:beta
577:HTR3E
571:HTR3D
565:HTR3C
559:HTR3B
553:HTR3A
507:Gene
496:Type
370:, by
121:1.A.9
105:SCOPe
96:SCOP2
6764:NMDA
6754:AMPA
6680:5-HT
6482:See
6465:see
6431:(RA)
6425:(RI)
6419:(RE)
6189:GluD
6124:NMDA
6054:AMPA
6012:Zinc
5998:(α1)
5989:(β4)
5985:(α1)
5977:(α7)
5969:(β2)
5965:(α4)
5957:(β4)
5953:(α3)
5772:GABA
5646:GABA
5638:GABA
5598:5-HT
5436:GJD4
5431:GJD3
5426:GJD2
5416:GJC3
5411:GJC2
5406:GJC1
5396:GJB7
5391:GJB6
5386:GJB5
5381:GJB4
5376:GJB3
5371:GJB2
5366:GJB1
5351:GJA9
5346:GJA8
5341:GJA5
5336:GJA4
5331:GJA3
5326:GJA1
5151:TRPV
5134:TRPP
5129:TRPN
5060:TRPM
5013:TRPC
5003:TRPA
4841:CLNS
4799:CLIC
4747:CLCN
4742:CFTR
4689:ANO1
4608:MiRP
4536:12.3
4531:12.2
4526:12.1
4517:11.3
4512:11.2
4498:10.2
4493:10.1
4283:α1-6
4097:GIRK
3511:α2.3
3498:α2.1
3465:α2.2
3285:GFDL
3177:ISBN
3104:PMID
3061:PMID
3017:PMID
2976:PMID
2919:PMID
2884:PMID
2849:PMID
2814:PMID
2759:ISBN
2728:PMID
2693:PMID
2644:PMID
2588:PMID
2532:PMID
2491:PMID
2432:PMID
2382:link
2362:ISBN
2199:NMDA
2197:and
2195:GABA
2091:P2X7
2087:P2X6
2083:P2X5
2079:P2X4
2075:P2X3
2071:P2X2
2067:P2X1
2063:N/A
1963:NMDA
1783:NBQX
1775:CNQX
1753:AMPA
1721:AMPA
1707:for
1698:NMDA
1682:The
1475:NMDA
1305:AMPA
1256:The
1241:GLRB
1164:GABA
1129:rho
892:GABA
853:ZACN
848:ZAC
602:5-HT
597:5-HT
592:5-HT
587:5-HT
582:5-HT
523:5-HT
447:GLIC
410:The
390:and
376:ions
279:LGIC
275:LICs
226:Ions
192:PDBj
188:PDBe
171:ECOD
161:Pfam
145:2bg9
116:TCDB
101:1cek
60:Pfam
6242:P2X
6221:ATP
6169:L1B
6164:L1A
5913:α10
5200:(+
5038:4AP
4951:HCN
4484:9.3
4479:9.2
4474:9.1
4465:8.2
4460:8.1
4451:7.5
4446:7.4
4441:7.3
4436:7.2
4431:7.1
4413:6.4
4408:6.3
4403:6.2
4398:6.1
4389:5.1
4380:4.3
4375:4.2
4370:4.1
4361:3.4
4356:3.3
4351:3.2
4346:3.1
4337:2.2
4332:2.1
4323:1.8
4318:1.7
4313:1.6
4308:1.5
4303:1.4
4298:1.3
4293:1.2
4288:1.1
4184:K2P
4164:7.1
4159:6.2
4154:6.1
4149:5.1
4144:4.2
4139:4.1
4124:3.4
4119:3.3
4114:3.2
4109:3.1
4090:2.6
4085:2.4
4080:2.3
4075:2.2
4070:2.1
4065:1.1
4051:ATP
4029:5.1
4024:4.2
4019:4.1
4014:3.1
4009:2.3
4004:2.2
3999:2.1
3994:1.1
3979:IK1
3969:SK3
3964:SK2
3959:SK1
3838:1.9
3833:1.8
3828:1.7
3823:1.6
3818:1.5
3813:1.4
3808:1.3
3803:1.2
3798:1.1
3687:Na:
3539:3.3
3534:3.2
3529:3.1
3483:2.1
3450:1.4
3445:1.3
3440:1.2
3435:1.1
3344:Ca:
3233:at
3203:doi
3151:doi
3096:doi
3051:doi
3007:doi
2966:PMC
2958:doi
2911:doi
2841:doi
2804:PMC
2796:doi
2792:361
2720:doi
2683:PMC
2675:doi
2634:PMC
2626:doi
2578:PMC
2568:doi
2522:doi
2518:279
2481:PMC
2471:doi
2422:PMC
2412:doi
2341:at
2211:FDA
2168:P2X
2163:P2X
2158:P2X
2153:P2X
2148:P2X
2143:P2X
2138:P2X
2059:P2X
2031:ATP
1981:PCP
1965:);
1932:or
1874:or
1623:GLU
1619:N3A
1617:GLU
1588:N2D
1586:GLU
1582:N2C
1580:GLU
1576:N2B
1574:GLU
1570:N2A
1568:GLU
1514:GLU
1465:GLU
1459:GLU
1453:GLU
1447:GLU
1441:GLU
1372:GLU
1366:GLU
1360:GLU
1354:GLU
1091:pi
653:α10
461:on
179:PDB
7002::
6933:NK
6834:))
6803:)
6704:AA
6547:))
6506:BA
6415::
6376::
6359::
6342::
6159:3B
6154:3A
6149:2D
6144:2C
6139:2B
6134:2A
5933:β4
5928:β3
5923:β2
5918:β1
5908:α9
5903:α7
5898:α6
5893:α5
5888:α4
5883:α3
5878:α2
5873:α1
5776:-ρ
5571::
5567:,
5422:D
5402:C
5362:B
5322:A
5204:):
4957:FC
4851:1B
4846:1A
4834:L1
4792:KB
4787:KA
4666:Cl
4259:18
4254:17
4249:16
4244:15
4239:13
4234:12
4229:10
4133:ir
4103:ir
4059:ir
3988:Ca
3947:β4
3942:β3
3937:β2
3932:β1
3927:α1
3899:K:
3850:Na
3843:7A
3789:Na
3616:γ4
3611:γ3
3606:γ2
3601:γ1
3589:β4
3584:β3
3579:β2
3574:β1
3520:Ca
3507:Ca
3494:Ca
3474:Ca
3461:Ca
3426:Ca
3324::
3244:.
3209:.
3199:28
3197:.
3157:.
3147:28
3145:.
3110:.
3102:.
3092:12
3090:.
3067:.
3059:.
3045:.
3041:.
3015:.
3003:89
3001:.
2997:.
2974:.
2964:.
2954:55
2952:.
2948:.
2925:.
2917:.
2907:67
2905:.
2880:51
2878:.
2855:.
2847:.
2837:25
2835:.
2812:.
2802:.
2790:.
2786:.
2767:.
2734:.
2726:.
2716:38
2714:.
2691:.
2681:.
2671:60
2669:.
2665:.
2642:.
2632:.
2622:56
2620:.
2616:.
2600:^
2586:.
2576:.
2562:.
2558:.
2544:^
2530:.
2516:.
2512:.
2489:.
2479:.
2469:.
2459:11
2457:.
2453:.
2430:.
2420:.
2406:.
2402:.
2390:^
2378:}}
2374:{{
2241:.
2213:.
1995:,
1991:,
1987:,
1983:,
1979:,
1975::
1946:;
1924::
1833:,
1829:,
1825:,
1821::
1811:,
1807:,
1803:,
1799::
1789:,
1785:,
1781:,
1777:,
1773::
1763:,
1759:,
1755:,
1751:,
1747::
1625:3B
1516:N1
1467:K2
1461:K1
1455:K7
1449:K6
1443:K5
1374:A4
1368:A3
1362:A2
1356:A1
1271:.
1195:α4
1191:α3
1187:α2
1183:α1
1141:ρ3
1137:ρ2
1133:ρ1
1024:γ3
1020:γ2
1016:γ1
982:β3
978:β2
974:β1
923:α6
919:α5
915:α4
911:α3
907:α2
903:α1
741:β4
737:β3
733:β2
729:β1
649:α9
645:α7
641:α6
637:α5
633:α4
629:α3
625:α2
621:α1
604:3E
599:3D
594:3C
589:3B
584:3A
442:.
394:.
386:,
374:,
316:.
306:Cl
302:Ca
300:,
296:,
294:Na
277:,
190:;
186:;
169:/
133:14
107:/
103:/
6982:)
6970:)
6935:1
6825:(
6816:(
6794:(
6766:)
6762:(
6756:)
6752:(
6685:)
6682:3
6678:(
6654:)
6651:3
6649:H
6643:2
6641:H
6635:1
6633:H
6631:(
6572:)
6570:β
6566:)
6564:2
6559:1
6557:(
6555:α
6553:(
6545:2
6540:1
6538:(
6536:β
6531:α
6529:(
6510:M
6508:/
6317:e
6310:t
6303:v
6277:7
6272:6
6267:5
6262:4
6257:3
6252:2
6247:1
6223:-
6204:2
6202:δ
6196:1
6194:δ
6129:1
6104:5
6099:4
6094:3
6089:2
6084:1
6075:)
6073:4
6068:3
6063:2
6058:1
6056:(
6000:2
5991:3
5987:2
5979:5
5971:3
5967:2
5959:3
5955:2
5943:ε
5938:δ
5852:β
5846:4
5844:α
5838:3
5836:α
5830:2
5828:α
5822:1
5820:α
5799:3
5797:ρ
5791:2
5789:ρ
5783:1
5781:ρ
5774:A
5765:θ
5760:π
5755:ε
5750:δ
5744:3
5742:γ
5736:2
5734:γ
5728:1
5726:γ
5720:3
5718:β
5712:2
5710:β
5704:1
5702:β
5696:6
5694:α
5688:5
5686:α
5680:4
5678:α
5672:3
5670:α
5664:2
5662:α
5656:1
5654:α
5648:A
5626:E
5621:D
5616:C
5611:B
5606:A
5600:3
5557:e
5550:t
5543:v
5307::
5287:3
5282:2
5277:1
5265:9
5260:8
5255:7
5250:6
5245:5
5240:4
5235:3
5230:2
5225:1
5220:0
5198:O
5196:2
5194:H
5181:6
5176:5
5171:4
5166:3
5161:2
5156:1
5144:2
5139:1
5122:3
5117:2
5112:1
5100:8
5095:7
5090:6
5085:5
5080:4
5075:3
5070:2
5065:1
5053:7
5048:6
5043:5
5033:4
5028:3
5023:2
5018:1
5009:)
5007:1
5005:(
4992::
4990:M
4977:4
4972:3
4967:2
4962:1
4943:3
4938:2
4933:1
4928:β
4921:4
4916:3
4911:2
4906:1
4901:α
4890::
4888:M
4866::
4864:H
4829:6
4824:5
4819:4
4814:3
4809:2
4804:1
4782:7
4777:6
4772:5
4767:4
4762:3
4757:2
4752:1
4733:4
4728:3
4723:2
4718:1
4706:2
4701:1
4668::
4623:3
4618:2
4613:1
4591:4
4586:3
4581:2
4576:1
4564:3
4559:2
4554:1
4549:β
4547:v
4545:K
4424:v
4422:K
4281:v
4279:K
4224:9
4219:7
4214:6
4209:5
4204:4
4199:3
4194:2
4189:1
4131:K
4101:K
4099:/
4057:K
4049:K
3986:K
3874:4
3869:3
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