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Enteroendocrine cell

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29: 187:, initiating digestive actions and detecting harmful substances and initiating protective responses. Enteroendocrine cells are located in the stomach, in the intestine and in the pancreas. Microbiota play key roles in the intestinal immune and metabolic responses in these enteroendocrine cells via their fermentation product ( 708:
Solcia E, Capella C, Buffa R, Usellini L, Fiocca R, Frigerio B, Tenti P, Sessa F (1981). "The diffuse endocrine-paracrine system of the gut in health and disease: ultrastructural features".
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strongly regulates their secretion, with parasympathetic stimulation stimulating insulin secretion and inhibiting glucagon secretion and sympathetic stimulation having opposite effect.
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Friis-Hansen L, Sundler F, Li Y, Gillespie PJ, Saunders TL, Greenson JK, Owyang C, Rehfeld JF, Samuelson LC (March 1998). "Impaired gastric acid secretion in gastrin-deficient mice".
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Kiba T (August 2004). "Relationships between the autonomic nervous system and the pancreas including regulation of regeneration and apoptosis: recent developments".
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Sternini C (February 2007). "Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing".
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and, in turn, coordinate antibacterial, mechanical, and metabolic branches of the host intestinal innate immune response to the commensal microbiota.
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Gilliam-Vigh, Hannah; Jorsal, Tina; Nielsen, Sophie W.; Forman, Julie L.; Pedersen, Jens; Poulsen, Steen S.; Vilsbøll, Tina; Knop, Filip K. (2023).
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Gilliam-Vigh, Hannah; Jorsal, Tina; Nielsen, Sophie W.; Forman, Julie L.; Pedersen, Jens; Poulsen, Steen S.; Vilsbøll, Tina; Knop, Filip K. (2023).
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to activate nervous responses. Enteroendocrine cells of the intestine are the most numerous endocrine cells of the body. They constitute an
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and non-carcinoid tumors develop from these cells. When a tumor arises it has the capacity to secrete large volumes of hormones.
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Gilliam-Vigh, Hannah; Jorsal, Tina; Rehfeld, Jens F.; Pedersen, Jens; Poulsen, Steen S.; Vilsbøll, Tina; Knop, Filip K. (2021).
2453: 1049:"Quantitative distribution of enteroendocrine cells in the gastrointestinal tract of the adult opossum, Didelphis virginiana" 590:
The very discovery of hormones occurred during studies of how the digestive system regulates its activities, as explained at
1880: 1309:"Expression of Cholecystokinin and its Receptors in the Intestinal Tract of Type 2 Diabetes Patients and Healthy Controls" 1283: 2852: 1486:"Expression of Neurotensin and Its Receptors Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls" 1245:"The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes" 203:
Intestinal enteroendocrine cells are not clustered together but spread as single cells throughout the intestinal tract.
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or peptides in response to various stimuli and release them into the bloodstream for systemic effect, diffuse them as
2446: 1634: 1574:"Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls" 884: 1624: 1573: 119: 2006: 989:"Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex" 2164: 489: 512: 223: 107: 1869: – Histology Learning System at Boston University - "Endocrine System: duodenum, enteroendocrine cells" 496:
are enteroendocrine and neuroendocrine cells also known for their similarity to chromaffin cells secreting
2781: 1912: 1147:"Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells" 493: 2642: 2330: 2063: 366: 243: 100: 2878: 2505: 2405: 2369: 2261: 1537:
Kitabgi P, Freychet P (August 1978). "Effects of neurotensin on isolated intestinal smooth muscles".
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Goswami C, Shimada Y, Yoshimura M, Mondal A, Oda S, Tanaka T, Sakai T, Sakata I (2015-06-26).
1090:"Microbial Control of Intestinal Homeostasis via Enteroendocrine Cell Innate Immune Signaling" 2883: 2419: 2204: 343: 1872: 1866: 1441:
Ormsbee HS, Fondacaro JD (March 1985). "Action of serotonin on the gastrointestinal tract".
2840: 2102: 1663: 1485: 1308: 641: 536: 1781:"Enteroendocrine tumors other than carcinoid: a review of clinically significant advances" 1652:"Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus" 8: 2619: 2572: 2564: 2151: 347: 1667: 2537: 2487: 2341: 1936: 1761: 1686: 1651: 1599: 1513: 1466: 1338: 1275: 1220: 1195: 1171: 1146: 1122: 1089: 1065: 1048: 1021: 988: 929: 904: 850: 825: 803: 667: 231: 1263: 250:, which also promotes triglyceride storage. K cells are mostly found in the duodenum. 2763: 2629: 2542: 2515: 1845: 1837: 1802: 1753: 1749: 1718: 1691: 1630: 1603: 1591: 1554: 1550: 1517: 1505: 1458: 1423: 1388: 1342: 1330: 1267: 1225: 1176: 1127: 1109: 1070: 1026: 1008: 969: 934: 880: 855: 795: 754: 717: 687: 1765: 1470: 1279: 749: 736: 2888: 2814: 2679: 2674: 2669: 2554: 2547: 2520: 2470: 2427: 2389: 2303: 2298: 2245: 2098: 1958: 1829: 1792: 1745: 1681: 1671: 1581: 1546: 1497: 1450: 1415: 1378: 1320: 1259: 1215: 1207: 1166: 1158: 1117: 1101: 1060: 1016: 1000: 961: 924: 916: 845: 837: 785: 744: 683: 679: 454: 172: 152: 49: 2438: 1419: 2697: 2689: 2582: 2577: 2495: 2478: 2122: 1820:
Camilleri M (October 2012). "Peripheral mechanisms in irritable bowel syndrome".
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found in crypts of the small intestine, especially in the duodenum and jejunum.
227: 180: 140: 1162: 1105: 2872: 2751: 2741: 2652: 2532: 1965: 1948: 1841: 1586: 1501: 1325: 1113: 1012: 965: 841: 606: 592: 270: 184: 230:. The enteroendocrine cells sense the metabolites from intestinal commensal 2835: 2801: 2791: 2729: 2070: 2037: 2027: 1953: 1849: 1806: 1757: 1695: 1595: 1509: 1392: 1334: 1271: 1229: 1180: 1131: 1030: 973: 938: 905:"Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing" 859: 824:
Moran GW, Leslie FC, Levison SE, Worthington J, McLaughlin JT (July 2008).
799: 758: 555: 508: 434: 207: 44: 1833: 1722: 1462: 1427: 1074: 721: 691: 317:. They modulate bile secretion, exocrine pancreas secretion, and satiety. 2809: 2724: 2326: 2225: 1970: 1558: 1383: 1366: 826:"Enteroendocrine cells: neglected players in gastrointestinal disorders?" 790: 516: 390: 219: 33:
Actions of the major digestive hormones secreted by enteroendocrine cells
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Parker HE, Habib AM, Rogers GJ, Gribble FM, Reimann F (February 2009).
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American Journal of Physiology. Gastrointestinal and Liver Physiology
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Proceedings of the Society for Experimental Biology and Medicine
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Gutierrez-Aguilar, Ruth; Woods, Stephen C (February 2011).
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Zverkov IV, Vinogradov VA, Smagin VG (October 1983). "".
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or ECL cells are a type of neuroendocrine cell secreting
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Current Opinion in Endocrinology, Diabetes & Obesity
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The Journal of Clinical Endocrinology & Metabolism
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The Journal of Clinical Endocrinology & Metabolism
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The Journal of Clinical Endocrinology & Metabolism
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Current Opinion in Endocrinology, Diabetes and Obesity
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Schonhoff SE, Giel-Moloney M, Leiter AB (June 2004).
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List of human cell types derived from the germ layers
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Jugder BE, Kamareddine L, Watnick PI (August 2021).
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Sternini C, Anselmi L, Rozengurt E (February 2008).
737:"The gut as the largest endocrine organ in the body" 710:
Scandinavian Journal of Gastroenterology. Supplement
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Pancreatic enteroendocrine cells are located in the
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Neuropeptide Function in the Gastrointestinal Tract
530: 198: 879:(5th, revised ed.). CRC Press. p. 1547. 1711:Biulleten' Eksperimental'noi Biologii I Meditsiny 1046: 2870: 1440: 467: 419:, and stimulate exocrine pancreatic secretion. 1536: 500:, which stimulates G cells to secrete gastrin. 472:Gastric enteroendocrine cells are found in the 668:"The new biology of gastrointestinal hormones" 381:Located in a increasing manner throughout the 2454: 1888: 1196:"Nutrition and L and K-enteroendocrine cells" 1087: 872: 361: 331:Stomach enteroendocrine cells, which release 1813: 1242: 1236: 1081: 16:Cell that produces gastrointestinal hormones 1360: 1358: 1047:Krause WJ, Yamada J, Cutts JH (June 1985). 980: 619:is expressed both by this cell type and by 350:with a close similarity to adrenomedullary 2858:List of human endocrine organs and actions 2461: 2447: 1895: 1881: 539:and produce most importantly the hormones 385:, with the highest levels found in the in 277:. L cells are primarily found in the 27: 1819: 1796: 1685: 1675: 1585: 1382: 1324: 1219: 1170: 1121: 1064: 1042: 1040: 1020: 928: 849: 789: 748: 433:Also called Delta cells, D cells secrete 393:, and control smooth muscle contraction. 2319: 1364: 1355: 951: 830:Therapeutic Advances in Gastroenterology 703: 701: 573: 338: 335:, and stimulate gastric acid secretion. 313:with a decreasing amount throughout the 285:(colon), but some are also found in the 1434: 1088:Watnick PI, Jugder BE (February 2020). 898: 896: 665: 2871: 1778: 1622: 1243:Drucker DJ, Nauck MA (November 2006). 1138: 1037: 734: 440: 183:. In a sense they are known to act as 2442: 1876: 1367:"A beautiful cell (or two or three?)" 698: 77:endocrinocyti gastroenteropancreatici 1735: 893: 876:Principles and Methods of Toxicology 101:H3.04.02.0.00024, H3.08.01.0.00003 13: 1408:The American Journal of Physiology 599: 14: 2905: 1860: 1750:10.1097/00006676-200408000-00019 1539:European Journal of Pharmacology 554:Other hormones produced include 531:Pancreatic enteroendocrine cells 503:Other hormones produced include 199:Intestinal enteroendocrine cells 120:Anatomical terms of microanatomy 1772: 1729: 1702: 1643: 1616: 1565: 1530: 1477: 1399: 1300: 1187: 743:. 12 Suppl 2 (suppl 2): S63–8. 612:short-chain fatty acid receptor 945: 817: 765: 728: 684:10.1152/physrev.1998.78.4.1087 659: 1: 2111:Bile and pancreatic secretion 1420:10.1152/ajpgi.1998.274.3.G561 1264:10.1016/s0140-6736(06)69705-5 750:10.1093/annonc/12.suppl_2.s63 652: 513:vasoactive intestinal peptide 468:Gastric enteroendocrine cells 224:vasoactive intestinal peptide 1798:10.1053/j.gastro.2005.03.078 1677:10.1371/journal.pone.0131554 1551:10.1016/0014-2999(78)90140-1 1212:10.1097/MED.0b013e32834190b5 1005:10.1016/j.immuni.2021.05.017 921:10.1097/MED.0b013e3282f43a73 476:, mostly at their base. The 305:(CCK), and have the highest 7: 666:Rehfeld JF (October 1998). 630: 494:Enterochromaffin-like cells 490:parasympathetic stimulation 367:Enterochromaffin-like cells 10: 2910: 2331:Interstitial cell of Cajal 1455:10.3181/00379727-178-42016 585: 426: 400: 362:Enterochromaffin-like cell 324: 244:gastric inhibitory peptide 206:Hormones secreted include 163:, or transmit them to the 2823: 2800: 2762: 2710: 2688: 2660: 2651: 2628: 2605: 2563: 2486: 2477: 2418: 2406:Enterohepatic circulation 2398: 2377: 2368: 2312: 2289: 2262:Segmentation contractions 2254: 2238: 2218: 2192: 2150: 2110: 2097: 2090: 2036: 2015: 1989: 1927: 1920: 1911: 1867:Histology image: 11604loa 1365:Brubaker PL (July 2012). 1163:10.1007/s00125-008-1202-x 1106:10.1016/j.tim.2019.09.005 549:autonomous nervous system 486:gastrin-releasing peptide 422: 396: 376: 320: 296: 253: 237: 157:gastrointestinal hormones 118: 106: 94: 82: 70: 65: 55: 43: 38: 26: 21: 1623:Daniel EE (1990-12-11). 966:10.1152/ajpgi.00411.2006 873:Wallace Hayes A (2007). 842:10.1177/1756283X08093943 492:to stimulate secretion. 346:are enteroendocrine and 169:enteric endocrine system 2526:Somatomammotrophic cell 2336:Basal electrical rhythm 2267:Migrating motor complex 1905:gastrointestinal system 275:glucagon-like peptide-2 260:glucagon-like peptide-1 155:function. They produce 2291:Enteric nervous system 1779:Warner RR (May 2005). 1587:10.1210/clinem/dgad372 1502:10.1210/clinem/dgad146 1326:10.1210/clinem/dgab367 578:Rare and slow growing 560:pancreatic polypeptide 453:(M cells) that are in 344:Enterochromaffin cells 189:short chain fatty acid 177:enteric nervous system 165:enteric nervous system 145:gastrointestinal tract 60:Gastrointestinal tract 2205:Enterochromaffin cell 2200:Enteroendocrine cells 1834:10.1056/NEJMra1207068 672:Physiological Reviews 642:Neuroendocrine tumors 574:Clinical significance 339:Enterochromaffin cell 137:Enteroendocrine cells 2841:Organ of Zuckerkandl 2831:Enteroendocrine cell 2193:Endocrine cell types 1384:10.1210/en.2012-1549 791:10.1210/en.2004-0051 593:Secretin § Discovery 537:islets of Langerhans 348:neuroendocrine cells 22:Enteroendocrine cell 2620:Parafollicular cell 2219:Exocrine cell types 2152:Glucose homeostasis 1668:2015PLoSO..1031554G 999:(8): 1683–1697.e3. 449:Different from the 441:Mo cell (or M cell) 179:is a subset of the 171:as a subset of the 2764:Islets of pancreas 2538:Corticotropic cell 2342:Gastrocolic reflex 1903:Physiology of the 1414:(3 Pt 1): G561–8. 1258:(9548): 1696–705. 1053:Journal of Anatomy 741:Annals of Oncology 389:, N cells release 2866: 2865: 2706: 2705: 2630:Parathyroid gland 2601: 2600: 2543:Gonadotropic cell 2516:Somatotropic cell 2436: 2435: 2414: 2413: 2364: 2363: 2360: 2359: 2299:Submucous plexus 2285: 2284: 2234: 2233: 2086: 2085: 735:Ahlman H (2001). 134: 133: 129: 2901: 2879:Endocrine system 2815:Corpora arenacea 2680:Zona reticularis 2675:Zona fasciculata 2670:Zona glomerulosa 2658: 2657: 2555:Chromophobe cell 2548:Thyrotropic cell 2484: 2483: 2471:endocrine system 2463: 2456: 2449: 2440: 2439: 2428:Peritoneal fluid 2390:Pancreatic juice 2375: 2374: 2317: 2316: 2304:Myenteric plexus 2246:Intestinal juice 2108: 2107: 2095: 2094: 2007:Gastric emptying 1959:Intrinsic factor 1925: 1924: 1918: 1917: 1897: 1890: 1883: 1874: 1873: 1854: 1853: 1817: 1811: 1810: 1800: 1785:Gastroenterology 1776: 1770: 1769: 1733: 1727: 1726: 1706: 1700: 1699: 1689: 1679: 1647: 1641: 1640: 1620: 1614: 1613: 1611: 1610: 1589: 1569: 1563: 1562: 1534: 1528: 1527: 1525: 1524: 1496:(9): 2211–2216. 1481: 1475: 1474: 1438: 1432: 1431: 1403: 1397: 1396: 1386: 1362: 1353: 1352: 1350: 1349: 1328: 1319:(8): 2164–2170. 1304: 1298: 1297: 1295: 1294: 1288: 1282:. Archived from 1249: 1240: 1234: 1233: 1223: 1191: 1185: 1184: 1174: 1142: 1136: 1135: 1125: 1094:Trends Microbiol 1085: 1079: 1078: 1068: 1044: 1035: 1034: 1024: 984: 978: 977: 949: 943: 942: 932: 900: 891: 890: 870: 864: 863: 853: 821: 815: 814: 812: 811: 802:. Archived from 793: 769: 763: 762: 752: 732: 726: 725: 705: 696: 695: 663: 618: 617: 411:mostly from the 407:S cells secrete 352:chromaffin cells 301:I cells secrete 258:L cells secrete 242:K cells secrete 173:endocrine system 161:local messengers 139:are specialized 126:edit on Wikidata 123: 50:Endocrine system 31: 19: 18: 2909: 2908: 2904: 2903: 2902: 2900: 2899: 2898: 2894:Secretory cells 2869: 2868: 2867: 2862: 2819: 2796: 2758: 2702: 2698:Chromaffin cell 2684: 2647: 2624: 2615:Follicular cell 2597: 2578:Median eminence 2559: 2496:Pars intermedia 2479:Pituitary gland 2473: 2469:Anatomy of the 2467: 2437: 2432: 2410: 2394: 2356: 2308: 2281: 2250: 2230: 2214: 2188: 2146: 2123:Cholecystokinin 2082: 2032: 2011: 1985: 1974: 1907: 1901: 1863: 1858: 1857: 1828:(17): 1626–35. 1818: 1814: 1777: 1773: 1734: 1730: 1707: 1703: 1662:(6): e0131554. 1648: 1644: 1637: 1621: 1617: 1608: 1606: 1570: 1566: 1535: 1531: 1522: 1520: 1482: 1478: 1439: 1435: 1404: 1400: 1363: 1356: 1347: 1345: 1305: 1301: 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2143: 2142: 2132: 2131: 2130: 2120: 2118:Enterogastrone 2114: 2112: 2105: 2092: 2088: 2087: 2084: 2083: 2081: 2080: 2079: 2078: 2068: 2067: 2066: 2056: 2055: 2054: 2043: 2041: 2034: 2033: 2031: 2030: 2025: 2019: 2017: 2013: 2012: 2010: 2009: 2004: 1999: 1993: 1991: 1987: 1986: 1984: 1983: 1982: 1981: 1976: 1972: 1966:Foveolar cells 1963: 1962: 1961: 1956: 1949:Parietal cells 1946: 1945: 1944: 1933: 1931: 1922: 1915: 1909: 1908: 1900: 1899: 1892: 1885: 1877: 1871: 1870: 1862: 1861:External links 1859: 1856: 1855: 1812: 1791:(6): 1668–84. 1771: 1728: 1701: 1642: 1635: 1615: 1564: 1529: 1476: 1433: 1398: 1354: 1299: 1235: 1186: 1157:(2): 289–298. 1137: 1100:(2): 141–149. 1080: 1059:(4): 591–605. 1036: 979: 960:(2): G457–61. 944: 892: 885: 865: 816: 784:(6): 2639–44. 764: 727: 697: 657: 656: 654: 651: 650: 649: 644: 639: 632: 629: 601: 598: 587: 584: 575: 572: 532: 529: 474:gastric glands 469: 466: 465: 464: 458: 447: 442: 439: 427:Main article: 424: 421: 401:Main article: 398: 395: 378: 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The 423:D cell 403:S cell 397:S cell 377:N cell 327:G cell 321:G cell 297:I cell 254:L cell 238:K cell 226:, and 45:System 2824:Other 2737:Ovary 2583:Stalk 2177:GLP-1 2091:Lower 1979:Mucus 1921:Upper 1762:S2CID 1600:S2CID 1514:S2CID 1467:S2CID 1339:S2CID 1287:(PDF) 1276:S2CID 1248:(PDF) 521:alpha 387:ileum 279:ileum 246:, an 151:with 141:cells 124:[ 113:62930 72:Latin 2385:Bile 1846:PMID 1838:ISSN 1803:PMID 1754:PMID 1719:PMID 1692:PMID 1631:ISBN 1592:PMID 1555:PMID 1506:PMID 1459:PMID 1424:PMID 1389:PMID 1331:PMID 1268:PMID 1226:PMID 1177:PMID 1128:PMID 1110:ISSN 1071:PMID 1027:PMID 1009:ISSN 970:PMID 935:PMID 881:ISBN 856:PMID 796:PMID 755:PMID 718:PMID 688:PMID 566:and 543:and 523:and 289:and 281:and 273:and 266:3-36 147:and 84:MeSH 2165:GIP 1971:HCO 1830:doi 1826:367 1793:doi 1789:128 1746:doi 1682:PMC 1672:doi 1582:doi 1547:doi 1498:doi 1494:108 1451:doi 1447:178 1416:doi 1412:274 1379:doi 1375:153 1321:doi 1317:106 1260:doi 1256:368 1216:PMC 1208:doi 1167:PMC 1159:doi 1118:PMC 1102:doi 1061:PMC 1057:140 1017:PMC 1001:doi 962:doi 958:292 925:PMC 917:doi 846:PMC 838:doi 786:doi 782:145 745:doi 680:doi 191:), 108:FMA 2875:: 1844:. 1836:. 1824:. 1801:. 1787:. 1783:. 1760:. 1752:. 1742:29 1740:. 1715:96 1713:. 1690:. 1680:. 1670:. 1660:10 1658:. 1654:. 1598:. 1590:. 1580:. 1576:. 1553:. 1543:50 1541:. 1512:. 1504:. 1492:. 1488:. 1465:. 1457:. 1445:. 1422:. 1410:. 1387:. 1373:. 1369:. 1357:^ 1337:. 1329:. 1315:. 1311:. 1274:. 1266:. 1254:. 1250:. 1224:. 1214:. 1204:18 1202:. 1198:. 1175:. 1165:. 1155:52 1153:. 1149:. 1126:. 1116:. 1108:. 1098:28 1096:. 1092:. 1069:. 1055:. 1051:. 1039:^ 1025:. 1015:. 1007:. 997:54 995:. 991:. 968:. 956:. 933:. 923:. 913:15 911:. 907:. 895:^ 854:. 844:. 832:. 828:. 794:. 780:. 776:. 753:. 739:. 714:70 712:. 700:^ 686:. 676:78 674:. 670:. 627:. 596:. 570:. 562:, 558:, 527:. 519:, 515:, 511:, 507:, 437:. 373:. 358:. 293:. 269:, 222:, 218:, 214:, 210:, 195:. 96:TH 2462:e 2455:t 2448:v 2338:) 2329:( 2158:) 2154:( 2101:/ 1973:3 1896:e 1889:t 1882:v 1852:. 1832:: 1809:. 1795:: 1768:. 1748:: 1725:. 1698:. 1674:: 1666:: 1639:. 1612:. 1584:: 1561:. 1549:: 1526:. 1500:: 1473:. 1453:: 1430:. 1418:: 1395:. 1381:: 1351:. 1323:: 1296:. 1262:: 1232:. 1210:: 1183:. 1161:: 1134:. 1104:: 1077:. 1033:. 1003:: 976:. 964:: 941:. 919:: 889:. 862:. 840:: 834:1 813:. 788:: 761:. 747:: 724:. 694:. 682:: 457:. 128:]

Index


System
Endocrine system
Gastrointestinal tract
Latin
MeSH
D019858
TH
H3.04.02.0.00024, H3.08.01.0.00003
FMA
62930
Anatomical terms of microanatomy
edit on Wikidata
cells
gastrointestinal tract
pancreas
endocrine
gastrointestinal hormones
local messengers
enteric nervous system
endocrine system
enteric nervous system
nervous system
chemoreceptors
short chain fatty acid
acetate
somatostatin
motilin
cholecystokinin
neurotensin

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