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binding. As a consequence, A22 inhibits MreB polymerization and thus disrupts the cytoskeleton of bacteria, causing defects of morphology and
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Bonez PC, Ramos AP, Nascimento K, Copetti PM, Souza ME, Rossi GG, Agertt VA, Sagrillo MR, Santos RC, Campos MM (October 2016).
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438:"Antibacterial, cyto and genotoxic activities of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride)"
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Despite its cytotoxic effects in human cells, A22 has been used as a research tool to investigate the bacterial
479:"A22 disrupts the bacterial actin cytoskeleton by directly binding and inducing a low-affinity state in MreB"
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Bean GJ, Flickinger ST, Westler WM, McCully ME, Sept D, Weibel DB, Amann KJ (June 2009).
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InChI=1S/C8H8Cl2N2S/c9-6-2-1-5(3-7(6)10)4-13-8(11)12/h1-3H,4H2,(H3,11,12)
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homolog MreB in its nucleotide-binding pocket, blocking simultaneous
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cells. The antibiotic activity of A22 has been studied primarily in
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Except where otherwise noted, data are given for materials in their
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However, A22 does not seem to be useful as an antibiotic in
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A22 acts as a reversible inhibitor of the bacterial
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41:(3,4-Dichlorophenyl)methyl carbamimidothioate
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201:Key: LZTCFLDZLBOLDW-UHFFFAOYSA-N
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50:3,4-Dichlorobenzyl carbamimidothioate
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13:
366:peripheral blood mononuclear cells
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315:-(3,4-dichlorobenzyl) isothiourea
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292:(at 25 °C , 100 kPa).
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410:"MreB Perturbing Compound A22"
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317:, is a chemical compound with
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1:
455:10.1016/j.micpath.2016.07.007
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380:. A22 binds directly to the
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321:activity. It is colorless,
222:C1=CC(=C(C=C1CSC(=N)N)Cl)Cl
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325:, and light-sensitive.
442:Microbial Pathogenesis
372:A22 as a research tool
348:Pseudomonas aeruginosa
414:www.emdmillipore.com
37:Preferred IUPAC name
329:Antibiotic activity
282: g·mol
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296:Infobox references
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495:10.1021/bi900014d
364:effects on human
304:Chemical compound
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154:CompTox Dashboard
97:Interactive image
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489:(22): 4852–7.
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117:ChEMBL1229059
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543:Chloroarenes
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483:Biochemistry
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417:. Retrieved
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378:cytoskeleton
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56:Identifiers
48:Other names
533:Antibiotics
356:due to its
323:hygroscopic
231:Properties
527:Categories
419:2018-02-14
396:References
390:chromosome
319:antibiotic
275:Molar mass
84:3D model (
73:22297-13-8
63:CAS Number
538:Thioureas
448:: 14–18.
368:(PBMCs).
362:genotoxic
358:cytotoxic
335:cell wall
513:19382805
464:27427089
337:protein
504:3951351
343:coccoid
129:PubChem
511:
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354:humans
280:235.13
215:SMILES
142:348494
108:ChEMBL
31:Names
382:actin
190:InChI
86:JSmol
509:PMID
460:PMID
360:and
339:MreB
17:A22
499:PMC
491:doi
450:doi
386:ATP
308:A22
159:EPA
132:CID
529::
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428:^
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256:Cl
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350:.
313:S
268:S
265:2
262:N
259:2
253:8
250:H
247:8
244:C
161:)
157:(
88:)
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