37:
161:
327:
reveals that similarities are largely confined to two regions. The first is located at the N-terminal extremity (N-region) and corresponds to the first 95 to 105
614:"Evolutionary conservation of excision repair in Schizosaccharomyces pombe: evidence for a family of sequences related to the Saccharomyces cerevisiae RAD2 gene"
510:
O'Donovan A, Davies AA, Moggs JG, West SC, Wood RD (September 1994). "XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair".
396:
with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum of seven
383:
561:
Habraken Y, Sung P, Prakash L, Prakash S (November 1993). "Yeast excision repair gene RAD2 encodes a single-stranded DNA endonuclease".
109:
181:
400:
complementation groups involved in this pathway: XP-A to XP-G. XP-G is one of the most rare and phenotypically
169:
17:
360:
165:
681:
122:
292:
424:
Tanaka K, Wood RD (February 1994). "Xeroderma pigmentosum and nucleotide excision repair of DNA".
364:
336:
331:. The second region is internal (I-region) and found towards the C terminus; it spans about 140
570:
519:
148:
8:
379:
332:
574:
523:
594:
543:
348:
344:
320:
638:
613:
482:
465:
643:
586:
535:
487:
441:
437:
194:
156:
114:
65:
633:
625:
612:
Carr AM, Sheldrick KS, Murray JM, al-Harithy R, Watts FZ, Lehmann AR (March 1993).
598:
578:
547:
527:
477:
433:
404:
of XP, showing anything from slight to extreme dysfunction in DNA excision repair.
232:
144:
78:
667:
90:
393:
324:
248:
41:
Crystal structure of flap endonuclease-1 r42e mutant from
Pyrococcus horikoshii
466:"Isolation of active recombinant XPG protein, a human DNA repair endonuclease"
675:
401:
281:
264:
236:
629:
376:
270:
228:
206:
647:
590:
539:
491:
445:
118:
340:
300:
239:
one strand of the duplex at the border with the single-stranded region.
352:
328:
304:
202:
102:
582:
531:
356:
296:
221:
663:
397:
85:
285:
231:
that makes structure-specific endonucleolytic incisions in a DNA
217:
97:
463:
386:
382:
disease, characterised by a high incidence of sunlight-induced
220:
that confers normal ultraviolet (UV) light resistance. It is a
214:
176:
36:
611:
310:
274:
210:
509:
363:
in XPG. The amino acid linking the N- and I-regions are not
659:
390:
138:
72:
60:
560:
464:
O'Donovan A, Scherly D, Clarkson SG, Wood RD (June 1994).
235:
containing a duplex region and single-stranded arms. XPGC
225:
658:
This article incorporates text from the public domain
205:
of XPG. The XPG protein can be corrected by a 133 kDa
303:that may act in a pathway that corrects mismatched
673:
347:pentapeptide (E-A--A-). It is possible that the
263:(Fission yeast), which are single-stranded DNA
505:
503:
501:
459:
457:
455:
419:
417:
605:
554:
498:
452:
423:
414:
35:
637:
481:
277:FEN-1, a structure-specific endonuclease;
370:
14:
674:
24:
25:
693:
375:Xeroderma pigmentosum (XP) is a
259:(Baker's yeast) and rad13 from
201:refers to, in this case, the
13:
1:
483:10.1016/S0021-9258(17)33956-X
407:
133:Available protein structures:
438:10.1016/0968-0004(94)90040-X
7:
242:
10:
698:
657:
224:-dependent, single-strand
261:Schizosaccharomyces pombe
175:
155:
137:
132:
128:
108:
96:
84:
71:
59:
51:
46:
34:
29:
257:Saccharomyces cerevisiae
630:10.1093/nar/21.6.1345
371:Xeroderma pigmentosum
30:XPG N terminal domain
355:are involved in the
299:double-stranded DNA
249:a family of proteins
575:1993Natur.366..365H
524:1994Natur.371..432O
426:Trends Biochem. Sci
380:autosomal recessive
361:DNA excision repair
357:catalytic mechanism
197:the protein domain
325:family of proteins
321:Sequence alignment
618:Nucleic Acids Res
195:molecular biology
191:
190:
187:
186:
182:structure summary
16:(Redirected from
689:
682:Protein families
652:
651:
641:
609:
603:
602:
583:10.1038/366365a0
558:
552:
551:
532:10.1038/371432a0
507:
496:
495:
485:
461:
450:
449:
421:
343:that includes a
337:highly conserved
130:
129:
39:
27:
26:
21:
697:
696:
692:
691:
690:
688:
687:
686:
672:
671:
670:
656:
655:
610:
606:
569:(6453): 365–8.
559:
555:
518:(6496): 432–5.
508:
499:
476:(23): 15965–8.
462:
453:
422:
415:
410:
373:
335:and contains a
284:and RAD27 from
251:that includes:
247:XPG belongs to
245:
42:
23:
22:
15:
12:
11:
5:
695:
685:
684:
654:
653:
604:
553:
497:
451:
412:
411:
409:
406:
372:
369:
318:
317:
314:
308:
289:
278:
268:
244:
241:
189:
188:
185:
184:
179:
173:
172:
159:
153:
152:
142:
135:
134:
126:
125:
112:
106:
105:
100:
94:
93:
88:
82:
81:
76:
69:
68:
63:
57:
56:
53:
49:
48:
44:
43:
40:
32:
31:
9:
6:
4:
3:
2:
694:
683:
680:
679:
677:
669:
665:
661:
649:
645:
640:
635:
631:
627:
624:(6): 1345–9.
623:
619:
615:
608:
600:
596:
592:
588:
584:
580:
576:
572:
568:
564:
557:
549:
545:
541:
537:
533:
529:
525:
521:
517:
513:
506:
504:
502:
493:
489:
484:
479:
475:
471:
470:J. Biol. Chem
467:
460:
458:
456:
447:
443:
439:
435:
431:
427:
420:
418:
413:
405:
403:
402:heterogeneous
399:
395:
392:
388:
385:
381:
378:
368:
366:
362:
358:
354:
350:
346:
342:
338:
334:
330:
326:
322:
315:
312:
309:
306:
302:
298:
294:
290:
287:
283:
282:fission yeast
279:
276:
272:
269:
266:
265:endonucleases
262:
258:
254:
253:
252:
250:
240:
238:
234:
230:
227:
223:
219:
216:
213:. XPGC is an
212:
208:
204:
200:
196:
183:
180:
178:
174:
171:
167:
163:
160:
158:
154:
150:
146:
143:
140:
136:
131:
127:
124:
120:
116:
113:
111:
107:
104:
101:
99:
95:
92:
89:
87:
83:
80:
77:
74:
70:
67:
64:
62:
58:
54:
50:
45:
38:
33:
28:
19:
18:XPG-Nterminus
621:
617:
607:
566:
562:
556:
515:
511:
473:
469:
429:
425:
374:
319:
260:
256:
246:
229:endonuclease
198:
192:
432:(2): 83–6.
389:. People's
341:amino acids
339:core of 27
329:amino acids
316:yeast DIN7.
301:exonuclease
47:Identifiers
408:References
305:base pairs
295:exo1, a 5'
280:RAD2 from
255:RAD2 from
203:N-terminus
145:structures
668:IPR006085
365:conserved
349:conserved
345:conserved
233:substrate
222:magnesium
209:protein,
103:PDOC00658
91:IPR006085
676:Category
664:InterPro
353:residues
333:residues
323:of this
291:fission
243:Homology
162:RCSB PDB
86:InterPro
648:8464724
599:4286568
591:8247134
571:Bibcode
548:4328388
540:8090225
520:Bibcode
492:8206890
446:8160271
398:genetic
351:acidic
286:budding
237:cleaves
218:protein
207:nuclear
98:PROSITE
66:PF00752
646:
639:309318
636:
597:
589:
563:Nature
546:
538:
512:Nature
490:
444:
387:cancer
288:yeast;
215:acidic
177:PDBsum
151:
141:
123:SUPFAM
79:CL0280
52:Symbol
595:S2CID
544:S2CID
394:cells
377:human
313:DHS1,
311:yeast
293:yeast
275:human
271:mouse
119:SCOPe
110:SCOP2
55:XPG_N
662:and
660:Pfam
644:PMID
587:PMID
536:PMID
488:PMID
442:PMID
391:skin
384:skin
273:and
211:XPGC
170:PDBj
166:PDBe
149:ECOD
139:Pfam
115:1a77
75:clan
73:Pfam
61:Pfam
634:PMC
626:doi
579:doi
567:366
528:doi
516:371
478:doi
474:269
434:doi
359:of
297:-3'
226:DNA
199:XPG
193:In
157:PDB
678::
666::
642:.
632:.
622:21
620:.
616:.
593:.
585:.
577:.
565:.
542:.
534:.
526:.
514:.
500:^
486:.
472:.
468:.
454:^
440:.
430:19
428:.
416:^
367:.
267:,;
168:;
164:;
147:/
121:/
117:/
650:.
628::
601:.
581::
573::
550:.
530::
522::
494:.
480::
448:.
436::
307:;
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
