Bupropion - Knowledge

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Furthermore, systemic administration of bupropion increases selection of the higheffort, high reward option in a PR-choice task in rats (Randall, Lee, Podurgiel, et al. 2014). Bupropion is also effective at rescuing motivational impairments in rodents. Administration of bupropion can rescue deficits in effort-related decision-making induced by pre-treatment with tetrabenazine (Randall, Lee, Nunes, et al. 2014; Nunes, Randall, Hart, et al. 2013) and the proinflammatory cytokine interleukin-6 (Yohn, Arif, et al. 2016). Bupropion has been reported to improve symptoms of apathy in cases of acquired brain injury, major depression (Corcoran et al. 2004) and frontotemporal dementia (Lin et al. 2016). However, several larger placebo-controlled studies suggest only limited effects of bupropion. In a study of 40 patients with schizophrenia, bupropion was found to have no significant effect on apathy or negative symptoms as a whole (Yassini et al. 2014). Furthermore, in a recent RCT of bupropion in HD, apathy was not significantly affected by the drug (Gelderblom et al. 2017). It is not clear whether bupropion lacks clinical efficacy, or whether bupropion as a whole is not affective at treating motivational impairments, or simply not effective in the clinical populations tested.

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decreased efficacy of generic bupropion, which prompted it to ask ConsumerLab.com to test the products in question. The tests showed that "one of a few generic versions of Wellbutrin XL 300 mg, sold as Budeprion XL 300 mg, didn't perform the same as the brand-name pill in the lab." The FDA investigated these complaints and concluded that Budeprion XL is equivalent to Wellbutrin XL in regard to bioavailability of bupropion and its main active metabolite hydroxybupropion. The FDA also said that coincidental natural mood variation is the most likely explanation for the apparent worsening of depression after the switch from Wellbutrin XL to Budeprion XL. On 3 October 2012, however, the FDA reversed this opinion, announcing that "Budeprion XL 300 mg fails to demonstrate therapeutic equivalence to Wellbutrin XL 300 mg." The FDA did not test the bioequivalence of any of the other generic versions of Wellbutrin XL 300 mg, but requested that the four manufacturers submit data on this question to the FDA by March 2013. As of October 2013 the FDA has made determinations on the formulations from some manufacturers not being bioequivalent.

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Bupropion misuse is uncommon. There have been a number of anecdotal and case-study reports of bupropion abuse, but the bulk of evidence indicates that the subjective effects of bupropion when taken orally are markedly different from those of addictive stimulants such as cocaine or amphetamine. However, bupropion, by non-conventional routes of administration like injection or insufflation, has been reported to be misused in the United States and Canada, notably in prisons.

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transporter. Whereas, bupropion is a moderately effective antidepressant when taken alone, thought to act by preventing dopamine and noradrenaline reuptake . Studies in mice have shown that the antidepressant-like effects of bupropion are potentiated by σ-1R agonists, and inhibited by σ-1R antagonists . These findings suggest that the combination of a σ-1R agonist and the dopamine/ noradrenaline reuptake inhibitor will be more effective than either treatment alone.

27373: 53: 1176: 27401: 10660: 8665: 11233: 1723:. When bupropion was one of several kinds of pills taken in an overdose, fever, muscle rigidity, muscle damage, hypertension or hypotension, stupor, coma, and respiratory failure have been reported. While most people recover, some people have died, having had multiple uncontrolled seizures and myocardial infarction. 1814:, with hydroxybupropion responsible for most of the inhibition. Additionally, bupropion and its metabolites may decrease expression of CYP2D6 in the liver. The end effect is a significant slowing of the clearance of other drugs metabolized by this enzyme. For instance, bupropion has been found to increase 1274:

The bupropion treatment course lasts for seven to twelve weeks, with the patient halting the use of tobacco about ten days into the course. After the course, the effectiveness of bupropion for maintaining abstinence from smoking declines over time, from 37% of tobacco abstinence at 3 months to 20% at

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Bupropion has several features that distinguish it from other antidepressants: for instance, unlike the majority of antidepressants, it does not usually cause sexual dysfunction, and the occurrence of sexual side effects is not different from placebo. Bupropion treatment is not associated with weight

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In 2009, the FDA issued a health advisory warning that the prescription of bupropion for smoking cessation has been associated with reports about unusual behavior changes, agitation and hostility. Some people, according to the advisory, have become depressed or have had their depression worsen, have

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formulation of alcohol-resistant bupropion called Wellbutrin SR, intended to be taken twice a day (as compared with three times a day for immediate-release Wellbutrin). In 2003, the FDA approved another sustained-release formulation called Wellbutrin XL, intended for once-daily dosing. Wellbutrin SR

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Papakostas GI, Stahl SM, Krishen A, Seifert CA, Tucker VL, Goodale EP, et al. (August 2008). "Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies".

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Following EMA's call for an industry-wide review of medicines for the possible presence of nitrosamines, GlaxoSmithKline paused batch release and distribution of bupropion 150 mg tablets in November 2022. In July 2023, EMA raised the acceptable daily intake of nitrosamines impurities, leading

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may develop. It is associated with higher doses of bupropion; many cases described are at higher than recommended doses. Concurrent antipsychotic medication appears to be protective. In most cases the psychotic symptoms are eliminated by reducing the dose, ceasing treatment or adding antipsychotic

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is a rare but serious adverse effect of bupropion. It is strongly dose-dependent: for the immediate release preparation, the seizure incidence is 0.4% at the dose 300–450 mg per day; the incidence climbs almost ten-fold for the higher than recommended dose of 600 mg. For comparison, the

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AXS-05 is a combination of dextromethorphan and bupropion and has been shown to have a rapid (within one week) positive effect in patients with depression. Dextromethorphan, as described above as part of Nuedexta, is a σ-1R agonist, an NMDA antagonist, and has affinity for the serotonin reuptake

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and behavior in children and adolescents, and 1.5-fold increase in the 18–24 age group. For this analysis the FDA combined the results of 295 trials of 11 antidepressants in order to obtain statistically significant results. Considered in isolation, bupropion was not statistically different from

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and fatigue in depressed patients. Bupropion is effective in the treatment of anxious depression and, contrary to common belief, does not exacerbate anxiety in this context. The effectiveness of bupropion for anxious depression is equivalent to that of SSRIs in the case of depression with low or

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While bupropion demonstrates some potential for misuse, this potential is less than of other commonly used stimulants, being limited by features of its pharmacology. Case reports describe misuse of bupropion as producing a "high" similar to cocaine or amphetamine usage but with less intensity.

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at the originally recommended dosage (400–600 mg/day) caused the withdrawal of the drug in 1986. Subsequently, the risk of seizures was found to be highly dose-dependent, and bupropion was re-introduced to the market in 1989 with a lower maximum recommended daily dose of 450 mg/day.

1306:. Systematic reviews of bupropion for the treatment of ADHD in both adults and children note that bupropion may be effective for ADHD but warn that this conclusion has to be interpreted with caution, because clinical trials were of low quality due to small sizes and risk of bias. Similarly to 9382:

In vitro functional studies showed agonist activity of solriamfetol at human, mouse, and rat TAAR1 receptors. hTAAR1 EC50 values (10–16 μM) were within the clinically observed therapeutic solriamfetol plasma concentration range and overlapped with the observed DAT/NET inhibitory potencies of

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In October 2007, two providers of consumer information on nutritional products and supplements, ConsumerLab.com and The People's Pharmacy, released the results of comparative tests of different brands of bupropion. The People's Pharmacy received multiple reports of increased side effects and

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Bupropion also acts as a dopamine reuptake inhibitor (Dwoskin et al. 2006), and has been used as a treatment for depression as well as a smoking cessation aid (Stahl et al. 2004). Bupropion has been shown to produce a dose-dependent increase in PR breakpoints (Bruijnzeel & Markou 2003).

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The metabolism of bupropion also seems to follow biphasic pharmacokinetics: the redistribution alpha phase with half-life of about 1 hour precedes the metabolism beta phase of about 12-30 hours. This might explain why abuse is unfeasible due to a short "high", as well as support the use of

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The metabolism of bupropion is highly species-dependent. As an example, oral bupropion results in hydroxybupropion levels that are 16-fold higher than those of bupropion itself in humans, whereas in rats, oral bupropion results in levels of bupropion that are 3.4-fold higher than those of

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had thoughts about suicide or dying, or have attempted suicide. This advisory was based on a review of anti-smoking products that identified 75 reports of "suicidal adverse events" for bupropion over ten years. Based on the results of follow-up trials this warning was removed in 2016.

1159:, in 1969. It was first approved for medical use in the United States in 1985. Bupropion was originally called by the generic name amfebutamone, before being renamed in 2000. In 2022, it was the 21st most commonly prescribed medication in the United States, with more than 25 3383:(EMA) recommended suspending a number of nationally approved medicines due to misrepresentation of bioequivalence study data by Micro Therapeutic Research Labs in India. The products recommended for suspension included several 300 mg modified-release bupropion tablets. 1366:

Bupropion, when used for treating long term weight gain over a period of 6 to 12 months, results in an average weight loss of 2.7 kg (5.9 lbs) over placebo. This is not much different from the weight loss produced by several other weight-loss medications such as

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The common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Bupropion has the highest incidence of insomnia of all second-generation antidepressants, apart from

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trials in the meta-analysis. Unpublished trials are more likely to be negative in findings, and other meta-analyses have included unpublished trials. Evidence suggests that the effectiveness of bupropion for depression is similar to that of other antidepressants.

1605:, sometimes severe, is observed in some people taking bupropion, both with and without pre-existing hypertension. Safety of bupropion in people with cardiovascular conditions and its general cardiovascular safety profile remain unclear due to the lack of data. 1391:

Bupropion is not effective in the treatment of cocaine dependence, but it is showing promise in reducing drug use in treating amphetamine-type stimulant use and cravings. Based on studies indicating that bupropion lowers the level of the inflammatory mediator

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mg). The IR formulation is generally administered thrice daily, the SR formulation twice daily, and the XL formulation once daily. The only marketed form of bupropion hydrobromide is Aplenzin, an extended-release oral tablet taken once daily (174, 348,

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symptoms such as depressed mood, irritability, difficulty concentrating, and increased appetite. Initially, bupropion slows the weight gain that often occurs in the first weeks after quitting smoking. With time, however, this effect becomes negligible.

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Protti M, Mandrioli R, Marasca C, Cavalli A, Serretti A, Mercolini L (September 2020). "New-generation, non-SSRI antidepressants: Drug-drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others".

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and fatigue. Bupropion, particularly the immediate release formulation, carries a higher risk of seizure than many other antidepressants, hence caution is recommended in patients with a history of seizure disorder. The medication is taken

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Damaj MI, Carroll FI, Eaton JB, Navarro HA, Blough BE, Mirza S, et al. (September 2004). "Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors".

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Cámara-Lemarroy CR, Guzmán-de la Garza FJ, Cordero-Pérez P, Alarcón-Galván G, Ibarra-Hernández JM, Muñoz-Espinosa LE, et al. (2013). "Bupropion reduces the inflammatory response and intestinal injury due to ischemia-reperfusion".

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form in the United States and Canada. In 1997, bupropion was approved by the FDA for use as a smoking cessation aid under the name Zyban. In 2006, Wellbutrin XL was similarly approved as a treatment for seasonal affective disorder.

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Hesse LM, He P, Krishnaswamy S, Hao Q, Hogan K, von Moltke LL, et al. (April 2004). "Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes".

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receptor agonists and antagonists, respectively. However, no data on the binding or functional effects of bupropion at the human sigma receptors seem to be available. In any case, bupropion has been reported to bind to rodent

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for depression. One meta-analysis reported a large effect size. However, there were methodological limitations with this meta-analysis, including using a subset of only five trials for the effect size calculation, substantial

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The addition of bupropion to a prescribed SSRI is a common strategy when people do not respond to the SSRI, and it is supported by clinical trials; however, it appears to be inferior to the addition of atypical antipsychotic

10920: 11230:"Постановление Правительства РФ от 30 июня 1998 г. N 681 "Об утверждении перечня наркотических средств, психотропных веществ и их прекурсоров, подлежащих контролю в Российской Федерации" (с изменениями и дополнениями)" 5128:

Cipriani A, Furukawa TA, Salanti G, Geddes JR, Higgins JP, Churchill R, et al. (February 2009). "Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis".

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Wilens TE, Hammerness PG, Biederman J, Kwon A, Spencer TJ, Clark S, et al. (February 2005). "Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder".

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In 2012, the US Justice Department announced that GlaxoSmithKline had agreed to plead guilty and pay a $ 3 billion fine, in part for promoting the unapproved use of Wellbutrin for weight loss and sexual dysfunction.

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Grandi SM, Shimony A, Eisenberg MJ (December 2013). "Bupropion for smoking cessation in patients hospitalized with cardiovascular disease: a systematic review and meta-analysis of randomized controlled trials".

10750: 1338:. A range of studies indicate that bupropion not only produces fewer sexual side effects than other antidepressants but can actually help to alleviate sexual dysfunction including sexual dysfunction induced by 10984: 1767:. The expected result is the increase of bupropion and decrease of hydroxybupropion blood concentration. The reverse effect (decrease of bupropion and increase of hydroxybupropion) can be expected with CYP2B6 6139:"Primary Care-Relevant Interventions for Tobacco and Nicotine Use Prevention and Cessation in Children and Adolescents: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force" 1289:

In children and adolescents, the use of bupropion for smoking cessation does not appear to offer any significant benefits. The evidence for its use to aid smoking cessation in pregnant women is insufficient.

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Akbar D, Rhee TG, Ceban F, Ho R, Teopiz KM, Cao B, et al. (October 2023). "Dextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials".

5315:"Efficacy of new-generation antidepressants assessed with the Montgomery-Asberg Depression Rating Scale, the gold standard clinician rating scale: A meta-analysis of randomised placebo-controlled trials" 10886: 9234:

Ferris RM, Russell A, Tang FL, Topham PA (1991). "Labeling in vivo of sigma receptors in mouse brain with -(+)-SKF 10,047: Effects of phencyclidine, (+)- and (−)-N-allylnormetazocine, and other drugs".

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Majeed A, Xiong J, Teopiz KM, Ng J, Ho R, Rosenblat JD, et al. (March 2021). "Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials".

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at therapeutic doses is thought to occupy greater than 50% of DAT sites. In accordance with its low DAT occupancy, no measurable dopamine release in the human brain was detected with bupropion (one 150

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Hart XM, Spangemacher M, Defert J, Uchida H, Gründer G (April 2024). "Update Lessons from PET Imaging Part II: A Systematic Critical Review on Therapeutic Plasma Concentrations of Antidepressants".

5615: 10910:"Products for which the marketing authorisations are recommended for suspension and marketing authorisation applications which do not satisfy the criteria for authorisation as adopted by the CHMP" 10637: 8329:

Kharasch ED, Neiner A, Kraus K, Blood J, Stevens A, Miller JP, et al. (November 2020). "Stereoselective Steady-State Disposition and Bioequivalence of Brand and Generic Bupropion in Adults".

14492: 5181:"The comparative evidence basis for the efficacy of second-generation antidepressants in the treatment of depression in the US: A Bayesian meta-analysis of Food and Drug Administration reviews" 2810:, is also characterized by inhibition of norepinephrine and dopamine reuptake and nicotinic inhibition (see the chart on the right). Bupropion has no meaningful direct activity at a variety of 3073:

may differ by as much as 7.5 times (with a half-life of 15–25 hours). Based on this, some researchers have advocated monitoring of the blood level of bupropion and hydroxybupropion.

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stating that antidepressants may increase the risk of suicide in people younger than 25. This warning is based on a statistical analysis conducted by the FDA which found a 2-fold increase in

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Overall, six months after the therapy, bupropion increases the likelihood of quitting smoking by approximately 1.6 fold as compared to placebo. In this respect, bupropion is as effective as

1033:(SSRI) antidepressant. Bupropion has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction, it is not associated with weight gain and 16552: 10686: 5377:"Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis" 3065:

The metabolism of bupropion is highly variable: the effective doses of bupropion received by persons who ingest the same amount of the drug may differ by as much as 5.5 times (with a

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Bupropion raises blood pressure in some people. One study showed an average rise of 6 mm Hg in systolic blood pressure in 10% of patients. The prescribing information notes that

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Vyas R, Nesheiwat Z, Ruzieh M, Ammari Z, Al-Sarie M, Grubb B (August 2020). "Bupropion in the treatment of postural orthostatic tachycardia syndrome (POTS): a single-center experience".

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in effect sizes between the selected trials—which led the authors to state that their findings in this area should be interpreted with "extreme caution"—and general lack of inclusion of

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Tafseer S, Gupta R, Ahmad R, Jain S, Bhatia MS, Gupta LK (January 2021). "Bupropion monotherapy alters neurotrophic and inflammatory markers in patients of major depressive disorder".

11091: 6337:"Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis" 5567:"Significant Treatment Effect of Bupropion in Patients With Bipolar Disorder but Similar Phase-Shifting Rate as Other Antidepressants: A Meta-Analysis Following the PRISMA Guidelines" 9321:

Simmler LD, Buchy D, Chaboz S, Hoener MC, Liechti ME (April 2016). "In Vitro Characterization of Psychoactive Substances at Rat, Mouse, and Human Trace Amine-Associated Receptor 1".

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incidence of unprovoked seizure in the general population is 0.07–0.09%, and the risk of seizure for a variety of other antidepressants is generally 0–0.5% at the recommended doses.

357: 14150: 9760: 10909: 10812: 10953: 5261:"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis" 3972: 1700: 3081:

hydroxybupropion. The species-dependent metabolism of bupropion is thought to be involved in species differences in its pharmacodynamic effects. For example, bupropion produces

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Costa R, Oliveira NG, Dinis-Oliveira RJ (August 2019). "Pharmacokinetic and pharmacodynamic of bupropion: integrative overview of relevant clinical and forensic aspects".

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Costa R, Oliveira NG, Dinis-Oliveira RJ (August 2019). "Pharmacokinetic and pharmacodynamic of bupropion: integrative overview of relevant clinical and forensic aspects".

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Gursahani H, Jolas T, Martin M, Cotier S, Hughes S, Macfadden W, et al. (2023). "Preclinical Pharmacology of Solriamfetol: Potential Mechanisms for Wake Promotion".

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Kumar S, Kodela S, Detweiler JG, Kim KY, Detweiler MB (November–December 2011). "Bupropion-induced psychosis: folklore or a fact? A systematic review of the literature".

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Musso DL, Mehta NB, Soroko FE, Ferris RM, Hollingsworth EB, Kenney BT (1993). "Synthesis and evaluation of the antidepressant activity of the enantiomers of bupropion".

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and clopidogrel, both potent CYP2B6 inhibitors, have been found to considerably increase bupropion levels as well as decrease levels of its metabolite hydroxybupropion.

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Ketter TA, Jenkins JB, Schroeder DH, Pazzaglia PJ, Marangell LB, George MS, et al. (October 1995). "Carbamazepine but not valproate induces bupropion metabolism".

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gain; on the contrary, the majority of studies observed significant weight loss in bupropion-treated participants. Bupropion treatment also is not associated with the

10976: 3000:. As for the relative bioavailability of the formulations, XL formulation has lower bioavailability (68%) compared to SR formulation and immediate release bupropion. 24118: 23778: 16545: 16350: 3703: 9055:

Rau KS, Birdsall E, Hanson JE, Johnson-Davis KL, Carroll FI, Wilkins DG, et al. (November 2005). "Bupropion increases striatal vesicular monoamine transport".

6098:"Interventions for Tobacco Cessation in Adults, Including Pregnant Persons: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force" 27491: 21286: 9383:

solriamfetol in vitro. TAAR1 agonist activity was unique to solriamfetol; neither the WPA modafinil nor the DAT/NET inhibitor bupropion had TAAR1 agonist activity.

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Tatsumi M, Groshan K, Blakely RD, Richelson E (December 1997). "Pharmacological profile of antidepressants and related compounds at human monoamine transporters".

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than a dopamine reuptake inhibitor. Accordingly, the clinical effects of bupropion are more consistent with noradrenergic activity than with dopaminergic actions.

26135: 4510:"Morbidity and Mortality Associated With Medications Used in the Treatment of Depression: An Analysis of Cases Reported to U.S. Poison Control Centers, 2000–2014" 3698:[Collegiate Board Resolution No. 784 – Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). 1358:

of bupropion for sexual desire disorder in women reported that although data were limited, bupropion appeared to be dose-dependently effective for the condition.

17664: 14184: 11687: 9710:"A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice" 1719:. For significant overdoses, seizures have been reported in about a third of all cases; other serious effects include hallucinations, loss of consciousness, and 26130: 8884:

Sánchez C, Hyttel J (August 1999). "Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding".

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Sánchez C, Hyttel J (August 1999). "Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding".

27526: 20553: 16755: 16410: 14527: 10878: 4622:"Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants" 1865:

have also been reported. However, in a notable exception, bupropion does not seem to affect the concentrations of CYP2D6 substrates fluoxetine and paroxetine.

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Wander TJ, Nelson A, Okazaki H, Richelson E (December 1986). "Antagonism by antidepressants of serotonin S1 and S2 receptors of normal human brain in vitro".

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Brimson JM, Brimson S, Chomchoei C, Tencomnao T (October 2020). "Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain".

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in the pharmacology of bupropion, and suggest that other actions may be responsible for its therapeutic effects. No data are available on occupancy of the

16538: 10419: 5426:"Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials" 9157:

Dhir A, Kulkarni SK (August 2008). "Possible involvement of sigma-1 receptors in the anti-immobility action of bupropion, a dopamine reuptake inhibitor".

8700:"BindingDB BDBM50048392 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one::BUPROPION::BUPROPION HYDROCHLORIDE::CHEMBL894::US9944618, Compound ID No. 176" 23289: 8038: 7248:

Lyonga Ngonge A, Nyange C, Ghali JK (February 2024). "Novel pharmacotherapeutic options for the treatment of postural orthostatic tachycardia syndrome".

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In April 2008, the FDA approved a formulation of bupropion as a hydrobromide salt instead of a hydrochloride salt, to be sold under the name Aplenzin by

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Baribeau D, Araki KF (May–June 2013). "Intravenous bupropion: a previously undocumented method of abuse of a commonly prescribed antidepressant agent".

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Spina E, Santoro V, D'Arrigo C (July 2008). "Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update".

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of bupropion in the treatment of depression and for other indications is unclear. However, it is thought to be related to the fact that bupropion is a

7789:"Antidepressants and suicidality in adults: statistical evaluation. (Presentation at Psychopharmacologic Drugs Advisory Committee; December 13, 2006)" 370: 11295: 4052:(2000). "International nonproprietary names for pharmaceutical substances (INN) : proposed international nonproprietary names : list 83". 1837:

increased approximately 35-fold when it was administered to people being treated with 300 mg/day bupropion. When people on bupropion are given

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Lile JA, Nader MA (2003). "The abuse liability and therapeutic potential of drugs evaluated for cocaine addiction as predicted by animal models".

7533:"Cardiovascular adverse events in the drug-development program of bupropion for smoking cessation: A systematic retrospective adjudication effort" 6229:"Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents" 4660: 4554:"A Systematic Review and Meta-Analysis Considering the Risk for Congenital Heart Defects of Antidepressant Classes and Individual Antidepressants" 27310: 22432: 15607: 11654: 11009:

Naglich AC, Brown ES, Adinoff B (2019). "Systematic review of preclinical, clinical, and post-marketing evidence of bupropion misuse potential".

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Naglich AC, Brown ES, Adinoff B (2019). "Systematic review of preclinical, clinical, and post-marketing evidence of bupropion misuse potential".

1404:, and other autoimmune conditions, but very little clinical evidence is available. Bupropion is not effective in treating chronic low back pain. 9865:

Carroll FI, Blough BE, Mascarella SW, Navarro HA, Lukas RJ, Damaj MI (2014). "Bupropion and bupropion analogs as treatments for CNS disorders".

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Karimollah A, Hemmatpur A, Vahid T (August 2021). "Revisiting bupropion anti-inflammatory action: involvement of the TLR2/TLR4 and JAK2/STAT3".

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Deconstructed Analogues of Bupropion Reveal Structural Requirements for Transporter Inhibition versus Substrate-Induced Neurotransmitter Release

8245:

Feinberg SS (November 2004). "Combining stimulants with monoamine oxidase inhibitors: a review of uses and one possible additional indication".

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Carroll FI, Blough BE, Mascarella SW, Navarro HA, Lukas RJ, Damaj MI (2014). "Bupropion and bupropion analogs as treatments for CNS disorders".

933: 24377: 22570: 19974: 17057: 12582: 10847: 2766: 1117: 302: 8028:"Highlight os Prescribing Information: CONTRAVE (naltrexone hydrochloride and bupropion hydrochloride) extended-release tablets, for oral use" 3425:

Brand names include Wellbutrin, Aplenzin, Budeprion, Buproban, Forfivo, Voxra, Zyban, Bupron, Bupisure, Bupep, Smoquite, Elontril, and Buxon.

23931: 23886: 23498: 22117: 22072: 21780: 18320: 16835: 13730: 7952:

Jefferson JW, Pradko JF, Muir KT (November 2005). "Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations".

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The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023)

1225:: 15% of participants on bupropion experienced a major depressive episode vs. 27% of those on placebo. Bupropion also improves depression in 194: 10773:"The smoking cessation aids varenicline (marketed as Chantix) and bupropion (marketed as Zyban and generics) suicidal ideation and behavior" 10600: 7466: 6916:

Cao DN, Shi JJ, Hao W, Wu N, Li J (June 2016). "Advances and challenges in pharmacotherapeutics for amphetamine-type stimulants addiction".

6384:

Ng QX (March 2017). "A Systematic Review of the Use of Bupropion for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents".

3323:

plasma bupropion levels with bupropion IR 100 mg t.i.d. (3x/day), bupropion SR 150 mg b.i.d. (2x/day), and bupropion XL 300 mg q.d. (1x/day)

24482: 24397: 23823: 23060: 23035: 22610: 21374: 20128: 19959: 18782: 18064: 17495: 16805: 16472: 16014: 16009: 15290: 15285: 15104: 13516: 13428: 12469: 11720: 11088: 7185: 3387:

GlaxoSmithKline to announce that distribution of bupropion 150 mg tablets would resume "across the EU and Europe" by the end of 2023.

2873:(NET) by bupropion and its metabolites. However, due to the increased exposure of hydroxybupropion over bupropion itself, which has higher 947: 10824: 1302:(ADHD) is not an approved indication of bupropion, and it is not mentioned in the current (2019) guideline on the ADHD treatment from the 24854: 24487: 24412: 24362: 24033: 23768: 23746: 23721: 23711: 23556: 23040: 23030: 23020: 22555: 22540: 22530: 22428: 22173: 22148: 22102: 21709: 21449: 21369: 20708: 20113: 20079: 18727: 18646: 18255: 17974: 17657: 17190: 16630: 16625: 14177: 4825: 2778: 26165: 26160: 10945: 10541: 8814:

Cusack B, Nelson A, Richelson E (May 1994). "Binding of antidepressants to human brain receptors: focus on newer generation compounds".

8282:"Bioequivalence and Therapeutic Equivalence of Generic and Brand Bupropion in Adults With Major Depression: A Randomized Clinical Trial" 6663:"Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review" 4948: 3964: 25213: 25163: 24108: 24058: 24000: 23995: 22964: 22535: 22168: 22163: 21990: 21333: 20609: 19918: 18772: 18762: 18265: 16760: 15793: 2716:(1) Values are in nanomolar (nM) units. The smaller the value, the more avidly the drug binds to or affects the site. (2) Affinities (K 26180: 26155: 10373: 3037: 2981:

After oral administration, bupropion is rapidly and completely absorbed reaching the peak blood plasma concentration after 1.5 hours (

24899: 24894: 24889: 24884: 24874: 24869: 24864: 24859: 24849: 24839: 24829: 24809: 24799: 24794: 24789: 24604: 24544: 24322: 24317: 24312: 24307: 24088: 23901: 23671: 23050: 23045: 22467: 17929: 17924: 17919: 17037: 16980: 16945: 16920: 16825: 16650: 16645: 16390: 16131: 14522: 14517: 14008: 11471: 10545: 9531:

Yetkin D, Yılmaz İA, Ayaz F (September 2023). "Anti-inflammatory activity of bupropion through immunomodulation of the macrophages".

7431:"Insomnia and somnolence associated with second-generation antidepressants during the treatment of major depression: a meta-analysis" 2799:

that are present in the blood plasma at comparable or much higher levels. In fact, bupropion could accurately be conceptualized as a

1443: 26175: 26170: 26150: 26145: 8478:

Bondarev ML, Bondareva TS, Young R, Glennon RA (August 2003). "Behavioral and biochemical investigations of bupropion metabolites".

3089:

effects in rodents, whereas oral bupropion at therapeutic doses seems to have much less or no potential for such effects in humans.

1676:(about 80% increase). The evidence is insufficient to determine whether bupropion is associated with suicides or suicidal behavior. 27481: 24769: 24764: 24714: 24337: 24332: 24327: 24218: 24213: 24093: 23798: 23696: 23691: 23676: 23611: 23606: 23353: 23245: 21024: 20408: 19565: 17062: 16515: 13424: 10610: 10347: 4360: 3665: 3315: 1299: 1246:

moderate anxiety, whereas SSRIs show a modest effectiveness advantage in terms of response rates for depression with high anxiety.

26778: 10321: 27303: 24734: 24624: 24614: 24609: 24302: 23793: 23282: 23205: 21036: 20420: 19577: 18175: 17335: 11515: 8752:

Richelson E, Nelson A (July 1984). "Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro".

3275: 1978: 1815: 1688: 9947:

Welch RM, Lai AA, Schroeder DH (March 1987). "Pharmacological significance of the species differences in bupropion metabolism".

6837: 4852:

Gautam M, Patel S, Zarkowski P (January 2022). "Practice patterns of bupropion co-prescription with antipsychotic medications".

3899: 3866: 3836: 3797: 25183: 24287: 24282: 23232: 23223: 17650: 14512: 14170: 12961: 1238: 1030: 10515: 7363: 6278:"Pharmacologic treatment of attention deficit hyperactivity disorder in adults: A systematic review and network meta-analysis" 25708: 23214: 13688: 12526: 11326: 11271: 10475: 10120: 9882: 9770: 8065:"Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers" 7876: 7333: 6000:"Diminishing benefit of smoking cessation medications during the first year: a meta-analysis of randomized controlled trials" 5053: 4942: 4811: 4709: 4090: 2912: 1795:. Indeed, carbamazepine decreases exposure to bupropion by 90% and increases exposure to hydroxybupropion by 94%. Ritonavir, 1623:

have been reported for bupropion. It is considered to be one of several antidepressants with greater risk of hepatotoxicity.

1164: 11250:Эфедрон (меткатинон) и его производные, за исключением производных, включенных в качестве самостоятельных позиций в перечень 4430:

Voican CS, Corruble E, Naveau S, Perlemuter G (April 2014). "Antidepressant-induced liver injury: a review for clinicians".

3474: 3339:(FDA) as an antidepressant on 30 December 1985, and marketed under the name Wellbutrin. However, a significant incidence of 19773: 12669: 10593: 9737: 8699: 4906: 3417:. In Australia, France, and the UK, smoking cessation is the only licensed use of bupropion, and no generics are marketed. 2877:

for the NET than the DAT, bupropion's overall pharmacological profile in humans may end up making it effectively more of a

2865:, though it is unknown if this effect is more pronounced than other DRIs. These findings raise questions about the role of 1668:

Bupropion prescribed for smoking cessation results in 25% increase of the risk of psychiatric side effects, in particular,

8383:"Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation" 3695: 2988:). Sustained release (SR) and extended release (XL) formulations have been designed to slow down absorption resulting in t 27471: 26920: 26693: 26550: 23236: 20984: 20857: 19511: 19371: 16499: 11753: 6804:"Drug Approval Package: Contrave (naltrexone hydrochloride/bupropion hydrochloride) Extended-Release Tablets NDA #200063" 11430: 11413: 4553: 2689: 25080: 23275: 14865: 12575: 11621: 10161: 10144: 6471:

Serretti A, Chiesa A (June 2009). "Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis".

4235:

Dhillon S, Yang LP, Curran MP (2008). "Bupropion: a review of its use in the management of major depressive disorder".

3691: 1556: 1408: 7488:

Telang S, Walton C, Olten B, Bloch MH (August 2018). "Meta-analysis: Second generation antidepressants and headache".

27421: 27317: 25208: 25198: 25178: 20950: 20942: 20875: 20363: 20355: 19464: 19456: 19389: 16572: 12954: 9576:"Bupropion for interferon-alpha-induced depression in patients with hepatitis C viral infection: an open-label study" 2940: 2878: 2862: 2835: 2134: 2104: 1588: 1347: 992: 967: 245: 134: 124: 10787: 9400:"Peripheral inflammatory effects of different interventions for treatment-resistant depression: A systematic review" 7616:

Pisani F, Oteri G, Costa C, Di Raimondo G, Di Perri R (2002). "Effects of psychotropic drugs on seizure threshold".

6704:"The Role of Bupropion in the Treatment of Women with Sexual Desire Disorder: A Systematic Review and Meta-Analysis" 27496: 27324: 25718: 25536: 25203: 25188: 25173: 24956: 20938: 20351: 19452: 16561: 16314: 13705: 12543: 10282:

Perrine DM, Ross JT, Nervi SJ, Zimmerman RH (2000). "A Short, One-Pot Synthesis of Bupropion (Zyban, Wellbutrin)".

2774: 2667: 2641: 2611: 2581: 2551: 2521: 2495: 1687:

Although studies are lacking, a handful of case reports suggest that abrupt discontinuation of bupropion may cause

5005: 27506: 27341: 27250: 25831: 25531: 25481: 25193: 23378: 21105: 21000: 20946: 20434: 20359: 19648: 19527: 19460: 18524: 13374: 10568: 9272:"Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications" 6803: 4905:. United States National Library of Medicine – National Center for Biotechnology Information. 28 July 2018. 4308:

Steinert T, Fröscher W (July 2018). "Epileptic Seizures Under Antidepressive Drug Treatment: Systematic Review".

3929: 3320: 1768: 1129: 612: 342: 226: 10407: 5850:

Hajizadeh A, Howes S, Theodoulou A, Klemperer E, Hartmann-Boyce J, Livingstone-Banks J, et al. (May 2023).

1826:

by 5.1-fold, while decreasing the exposure to its main metabolite by 1.5-fold. As another example, the ratio of

27486: 27296: 26271: 26140: 26125: 26120: 25703: 23418: 23254: 16995: 16591: 16519: 1303: 8027: 5516:

Gartlehner G, Nussbaumer-Streit B, Gaynes BN, Forneris CA, Morgan LC, Greenblatt A, et al. (March 2019).

1567:(MAOIs). The label recommends that caution should be exercised when treating people with liver damage, severe 703: 27521: 26658: 26115: 26110: 25698: 25693: 25458: 24537: 21028: 20412: 19569: 15575: 14016: 12568: 11464: 11237: 10441: 3696:"RDC Nº 784 – Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" 2853:(PET) studies is approximately 20%, with a mean occupancy range of about 14 to 26%. For comparison, the NDRI 2770: 1121: 10708: 7735:

Herstowska M, Komorowska O, Cubała WJ, Jakuszkowiak-Wojten K, Gałuszko-Węgielnik M, Landowski J (May 2014).

3757: 3725: 1637:

Bupropion use by mothers in the first trimester of pregnancy is associated with 23% increase of the odds in

1221:

Over the autumn and winter months, bupropion prevents development of depression in those who have recurring

26072: 25075: 24512: 23196: 22392: 21718: 21004: 19531: 17621: 16495: 14212: 14193: 10820: 10746: 10743:"Public Health Advisory: FDA requires new boxed warnings for the smoking cessation drugs Chantix and Zyban" 10714: 10641: 10605: 10484: 10447: 10413: 7792: 6838:"Contrave Extended-Release – naltrexone hydrochloride and bupropion hydrochloride tablet, extended release" 6809: 5014: 3699: 3336: 2866: 2850: 1645: 1380: 1279: 754: 5627: 27441: 26838: 26545: 26052: 26047: 25092: 24203: 21684: 21097: 20988: 20633: 19984: 19515: 18777: 18483: 17979: 16685: 15859: 15135: 12126: 12059: 11287: 8727: 7081:"Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review" 5179:

Monden R, Roest AM, van Ravenzwaaij D, Wagenmakers EJ, Morey R, Wardenaar KJ, et al. (August 2018).

3999:"Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers" 3637:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)" 2962: 2425: 2399: 1896: 1564: 1393: 1222: 842: 7796: 6047:

Livingstone-Banks J, Norris E, Hartmann-Boyce J, West R, Jarvis M, Chubb E, et al. (October 2019).

27511: 27461: 27426: 27391: 25683: 24561: 24553: 23065: 22640: 21903: 21479: 21071: 20728: 20133: 19622: 17009: 16735: 16605: 14854: 14366: 13966: 13432: 12707: 11889: 11797: 10879:"EMA recommends suspension of medicines due to unreliable studies from Micro Therapeutic Research Labs" 8676:. University of North Carolina at Chapel Hill and the United States National Institute of Mental Health 6516:"A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor" 4621: 3110: 2928: 2870: 2297: 2058: 1520: 1459: 1397: 1145: 17: 5208: 3232:

There have been reported cases of false-positive urine amphetamine tests in persons taking bupropion.

1482:

salt. The available forms of bupropion hydrochloride include IR (instant-release) tablets (50, 75, 100

1314:

for ADHD, and several weeks of treatment are required for therapeutic effects. This is in contrast to

831: 27015: 25996: 25826: 24148: 23856: 13940: 13436: 12876: 11901: 10235:"Frequency of false positive amphetamine screens due to bupropion using the Syva EMIT II immunoassay" 6335:

Cortese S, Adamo N, Del Giovane C, Mohr-Jensen C, Hayes AJ, Carucci S, et al. (September 2018).

5955:

Mooney ME, Sofuoglu M (July 2006). "Bupropion for the treatment of nicotine withdrawal and craving".

5180: 5100: 4281:

Baldwin DS, Papakostas GI (2006). "Symptoms of fatigue and sleepiness in major depressive disorder".

4049: 3636: 3380: 3249: 2815: 1872:

threshold, and therefore can potentially interact with other medications that also lower it, such as

1708: 1018: 25023: 11066: 3589:"15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL" 2965:(TNFα). The catecholaminergic actions of bupropion may be involved in its immunomodulatory effects. 1503:

mg of bupropion hydrochloride). In addition to single-drug formulations, bupropion is formulated in

27436: 27352: 27245: 27019: 26902: 26798: 26788: 26688: 24530: 23087: 22654: 21946: 21732: 21524: 20163: 17595: 13528: 13499: 13299: 11457: 11412:

Emmanuel NP, Brawman-Mintzer O, Morton WA, Book SW, Johnson MR, Lorberbaum JP, et al. (2000).

10601:"Review of therapeutic equivalence: generic bupropion XL 300 mg and Wellbutrin XL 300 mg" 9822:

Preskorn SH (1991). "Should bupropion dosage be adjusted based upon therapeutic drug monitoring?".

9105:"Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders" 3016: 2819: 2781:. Pharmacological actions of bupropion, to a substantial degree, are due to its active metabolites 1923: 1877: 1275:

one year. It is unclear whether extending bupropion treatment helps to prevent relapse of smoking.

858: 11377:

Emmanuel NP, Lydiard RB, Ballenger JC (August 1991). "Treatment of social phobia with bupropion".

8562:"Bupropion Inhibits Serotonin Type 3AB Heteromeric Channels at Clinically Relevant Concentrations" 7130:

Urquhart DM, Hoving JL, Assendelft WW, Roland M, van Tulder MW (January 2008). Urquhart DM (ed.).

6178:

Claire R, Chamberlain C, Davey MA, Cooper SE, Berlin I, Leonardi-Bee J, et al. (March 2020).

27476: 26783: 26062: 26021: 25745: 25613: 25608: 25598: 25526: 25516: 25270: 25260: 25243: 25102: 22834: 22400: 22237: 21722: 21144: 20463: 20312: 19677: 18852: 18537: 18078: 16725: 16332: 14095: 13693: 13539: 12977: 12531: 6987:

Mikocka-Walus AA, Turnbull DA, Moulding NT, Wilson IG, Andrews JM, Holtmann GJ (September 2006).

6661:

Goldstein I, Kim NN, Clayton AH, DeRogatis LR, Giraldi A, Parish SJ, et al. (January 2017).

3446: 3434: 3348: 3102: 2932: 2874: 2811: 1638: 1141: 1133: 1110: 1014: 282: 148: 8611:"The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors" 5259:

Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. (April 2018).

27069: 26858: 26828: 26222: 26190: 26099: 25738: 25506: 25143: 25052: 25044: 25036: 25028: 24357: 24158: 23866: 23408: 22863: 22830: 22472: 22388: 22233: 21790: 21714: 21660: 21223: 21160: 21136: 20903: 20525: 20487: 20455: 20430: 19778: 19693: 19669: 19417: 19206: 19061: 18868: 18864: 18844: 18545: 18529: 18157: 18094: 18074: 17763: 17014: 16511: 16507: 15914: 15190: 14620: 14573: 13165: 12816: 12366: 11837: 11061: 3965:"Zyban 150 mg prolonged release film-coated tablets – Summary of Product Characteristics (SPC)" 3086: 1435:. However, only limited benefits of bupropion in the treatment of apathy have been observed in 1428: 450: 16530: 10110: 8104:

Schmid Y, Rickli A, Schaffner A, Duthaler U, Grouzmann E, Hysek CM, et al. (April 2015).

4799: 27446: 27346: 26773: 26057: 26001: 25874: 25859: 25848: 25501: 25238: 25218: 23763: 23105: 22676: 22396: 21936: 21748: 21666: 21538: 21156: 21140: 20899: 20895: 20751: 20483: 20471: 20459: 20173: 19689: 19673: 19413: 19409: 18848: 18533: 17580: 17529: 17490: 15632: 15564: 15038: 14340: 11807: 5616:"Antidepressant-Associated Sexual Dysfunction: A Potentially Avoidable Therapeutic Challenge" 4932: 3196: 3106: 3056: 3033: 2793: 2348: 2081: 1959: 1841:, about 30% increase of exposure to both drugs is observed, with enhanced mood but decreased 1620: 1342:

antidepressants. There have also been small studies suggesting that bupropion or a bupropion/

1137: 811: 694: 510: 9622: 6780: 6763: 2958:. One such mechanism underlying these effects may be reduced levels of the pro-inflammatory 27466: 26698: 26378: 26237: 26232: 25889: 25879: 25869: 25733: 25521: 25473: 25418: 25408: 25158: 23586: 17575: 17440: 17420: 17260: 17205: 17120: 16910: 16503: 16375: 15904: 15448: 15180: 14610: 14589: 14201: 13269: 12592: 12486: 12401: 10385: 10320:. U.S. Food and Drug Administration Center for Drug Evaluation and Research. Archived from 10291: 9006:

Egerton A, Shotbolt JP, Stokes PR, Hirani E, Ahmad R, Lappin JM, et al. (March 2010).

7531:

Kittle J, Lopes RD, Huang M, Marquess ML, Wilson MD, Ascher J, et al. (October 2017).

6289: 5326: 4620:

Eap CB, Gründer G, Baumann P, Ansermot N, Conca A, Corruble E, et al. (October 2021).

3066: 2842: 2803:

of these metabolites. Overall action of these metabolites, and particularly one enantiomer

2246: 2035: 1788: 1739:, drug interactions with CYP2B6 inhibitors are possible: this includes such medications as 1508: 1455: 1376: 1286:. Combining bupropion and nicotine replacement therapy does not improve the quitting rate. 1263: 763: 646: 523: 11186:

Stassinos GL, Klein-Schwartz W (2016). "Bupropion "Abuse" Reported to US Poison Centers".

8106:"Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects" 4804:

The American Psychiatric Association Publishing Textbook of Mood Disorders, Second Edition

8: 27516: 27456: 27431: 26743: 26540: 26286: 26089: 26036: 25688: 25603: 25593: 25541: 25511: 25447: 25334: 25265: 25255: 25138: 22838: 22404: 22344: 22032: 21648: 20869: 20849: 20467: 20377: 19383: 19363: 19210: 18860: 18541: 18086: 17590: 17475: 17460: 17395: 16990: 16189: 16034: 15899: 15627: 15484: 15310: 15175: 14830: 14605: 13549: 13335: 13214: 13186: 13016: 12605: 12312: 12252: 11108:

Phillips D (February 2012). "Wellbutrin®: misuse and abuse by incarcerated individuals".

8381:

Lukas RJ, Muresan AZ, Damaj MI, Blough BE, Huang X, Navarro HA, et al. (June 2010).

8280:

Kharasch ED, Neiner A, Kraus K, Blood J, Stevens A, Schweiger J, et al. (May 2019).

7737:"Severe skin complications in patients treated with antidepressants: a literature review" 7040:"Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD" 3245: 3049: 2982: 2786: 2762: 1947: 1900: 1796: 1631: 1465: 1229:, with the efficacy and risk of affective switch being similar to other antidepressants. 1197: 1043: 743: 637: 502: 289: 27010: 10813:"Safety Alerts for Human Medical Products – Chantix (varenicline) and Zyban (bupropion)" 10343: 10295: 6424:"An update on the pharmacotherapy of attention-deficit/hyperactivity disorder in adults" 6293: 6227:

Wolraich ML, Hagan JF, Allan C, Chan E, Davison D, Earls M, et al. (October 2019).

5876: 5851: 5518:"Second-generation antidepressants for preventing seasonal affective disorder in adults" 5330: 4371: 4131:"Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant" 862: 25899: 25894: 24996: 24421: 23448: 23422: 23301: 23169: 22727: 22307: 21999: 21164: 20557: 20491: 19697: 17676: 17510: 17450: 17360: 17285: 17180: 17165: 17155: 16564: 16274: 14300: 13944: 13753: 13722: 13634: 13280: 13209: 13096: 12885: 12779: 12739: 12701: 12693: 12660: 12639: 11503: 11499: 11211: 11133: 11034: 10259: 10234: 10174: 9874: 9687: 9637: 9600: 9575: 9556: 9513: 9465: 9448: 9429: 9298: 9271: 9129: 9104: 9080: 9032: 9007: 8635: 8610: 8586: 8561: 8542: 8460: 8407: 8382: 8354: 8306: 8281: 8192: 8135: 7918: 7893: 7844: 7819: 7761: 7736: 7685: 7660: 7641: 7557: 7532: 7513: 7458: 7411: 7156: 7131: 7015: 6988: 6893: 6868: 6762:

Li Z, Maglione M, Tu W, Mojica W, Arterburn D, Shugarman LR, et al. (April 2005).

6741: 6728: 6703: 6638: 6613: 6589: 6564: 6496: 6448: 6423: 6361: 6336: 6312: 6277: 6253: 6228: 6204: 6179: 6073: 6048: 6024: 5999: 5980: 5927: 5900: 5824: 5797: 5773: 5746: 5727: 5678: 5591: 5566: 5542: 5517: 5477:"Selective publication of antidepressant trials and its influence on apparent efficacy" 5452: 5425: 5401: 5376: 5349: 5314: 5285: 5260: 5221: 5154: 4877: 4770: 4745: 4701: 4652: 4581: 4483: 4333: 4260: 4207: 4182: 4155: 4130: 4023: 3998: 3613: 3588: 3564: 2831: 2827: 1560: 1335: 1156: 1082: 256: 12946: 12560: 10977:"Bupropion to be made available in the UK again from December 2023, says manufacturer" 10638:"Budeprion XL 300 mg not therapeutically equivalent to Wellbutrin XL 300 mg" 8862: 8491: 8223: 6719: 6565:"Women's sexual dysfunction associated with psychiatric disorders and their treatment" 6540: 6515: 6352: 6276:

Elliott J, Johnston A, Husereau D, Kelly SE, Eagles C, Charach A, et al. (2020).

6096:

Patnode CD, Henderson JT, Coppola EL, Melnikow J, Durbin S, Thomas RG (January 2021).

5276: 5142: 2030:(μM) in human cells, unless noted otherwise (Lesser values indicate greater potency.) 1699:

Bupropion is considered moderately dangerous in overdose. According to an analysis of

27501: 27102: 26651: 26227: 25974: 25964: 25934: 25864: 25556: 25299: 24971: 22956: 22846: 22348: 21593: 21152: 20968: 20819: 20479: 20389: 20381: 20265: 20087: 19685: 19535: 19323: 19164: 19110: 18744: 18469: 18461: 18196: 18102: 17900: 17884: 17737: 17600: 17320: 17200: 17080: 16265: 15003: 14710: 14285: 13893: 13608: 13086: 13081: 12855: 12822: 12770: 12715: 12688: 12503: 12405: 11924: 11435: 11394: 11390: 11359: 11322: 11267: 11203: 11168: 11125: 11026: 10907: 10876: 10264: 10215: 10166: 10116: 10034: 9999: 9964: 9926: 9888: 9878: 9831: 9804: 9800: 9766: 9729: 9691: 9679: 9641: 9605: 9560: 9548: 9517: 9505: 9470: 9433: 9421: 9373: 9338: 9303: 9252: 9212: 9174: 9170: 9134: 9072: 9068: 9037: 9023: 8988: 8937: 8901: 8866: 8831: 8796: 8792: 8761: 8640: 8626: 8591: 8534: 8495: 8452: 8412: 8358: 8346: 8311: 8262: 8227: 8196: 8184: 8127: 8086: 8004: 8000: 7969: 7923: 7872: 7849: 7766: 7717: 7690: 7633: 7629: 7598: 7562: 7505: 7450: 7415: 7403: 7300: 7265: 7230: 7226: 7161: 7112: 7061: 7020: 6969: 6933: 6898: 6785: 6745: 6733: 6684: 6643: 6594: 6545: 6488: 6453: 6401: 6366: 6317: 6258: 6209: 6160: 6119: 6078: 6029: 5972: 5932: 5901:"Effectiveness of smoking cessation therapies: a systematic review and meta-analysis" 5881: 5829: 5778: 5731: 5719: 5670: 5596: 5547: 5498: 5457: 5406: 5354: 5290: 5213: 5146: 4977:"United States Patent 3,819,706: Meta-chloro substituted α-butylamino-propiophenones" 4938: 4881: 4869: 4817: 4807: 4775: 4715: 4705: 4656: 4644: 4585: 4573: 4531: 4487: 4447: 4409: 4325: 4290: 4264: 4252: 4248: 4212: 4160: 4086: 4028: 3789: 3618: 3568: 3556: 3260: 3214: 3172: 3168: 2997: 2947: 2823: 1822:, a CYP2D6 substrate, by 5-fold. Bupropion has also been found to increase levels of 1661: 1576: 1544: 1468: 1351: 1022: 394: 382: 218: 26793: 17099: 17095: 17023: 11215: 11038: 10178: 9120: 9084: 8464: 8139: 7965: 7645: 7517: 7462: 5984: 5682: 5375:

Stone MB, Yaseen ZS, Miller BJ, Richardville K, Kalaria SN, Kirsch I (August 2022).

5158: 4337: 3790:"Zyban 150 mg prolonged release tablets – Summary of Product Characteristics (SmPC)" 27376: 27201: 27089: 25969: 25949: 25789: 25453: 25428: 25372: 25012: 23990: 23956: 23453: 23433: 23309: 21858: 21680: 21093: 20332: 20316: 20302: 20205: 20029: 19640: 17470: 17280: 17175: 17047: 16610: 16586: 16370: 16225: 15597: 14993: 14690: 14630: 14447: 14361: 13962: 13948: 13764: 13136: 13061: 12917: 12837: 12476: 12419: 12355: 12202: 11425: 11386: 11351: 11195: 11160: 11137: 11117: 11071: 11018: 10299: 10254: 10246: 10205: 10156: 10026: 9991: 9956: 9918: 9870: 9796: 9721: 9671: 9633: 9595: 9587: 9540: 9497: 9460: 9411: 9365: 9330: 9293: 9283: 9244: 9204: 9166: 9124: 9116: 9064: 9027: 9019: 8980: 8929: 8893: 8858: 8823: 8788: 8630: 8622: 8581: 8573: 8546: 8526: 8487: 8444: 8402: 8394: 8338: 8301: 8293: 8254: 8219: 8174: 8166: 8117: 8076: 7996: 7961: 7913: 7905: 7839: 7831: 7756: 7748: 7680: 7672: 7625: 7590: 7552: 7544: 7497: 7442: 7395: 7355: 7292: 7257: 7222: 7191: 7151: 7147: 7143: 7102: 7092: 7051: 7010: 7000: 6961: 6925: 6888: 6880: 6775: 6723: 6715: 6674: 6633: 6625: 6584: 6576: 6535: 6527: 6500: 6480: 6443: 6435: 6393: 6356: 6348: 6307: 6297: 6248: 6240: 6199: 6195: 6191: 6150: 6109: 6068: 6064: 6060: 6019: 6011: 5964: 5922: 5912: 5871: 5867: 5863: 5819: 5809: 5768: 5758: 5709: 5662: 5586: 5578: 5537: 5533: 5529: 5488: 5447: 5437: 5396: 5388: 5344: 5334: 5280: 5272: 5225: 5203: 5195: 5138: 5108: 4934:

Case Studies in Medical Toxicology: From the American College of Medical Toxicology

4861: 4765: 4761: 4757: 4697: 4636: 4565: 4526: 4521: 4509: 4479: 4443: 4439: 4401: 4317: 4244: 4202: 4194: 4150: 4142: 4061: 4018: 4010: 3608: 3600: 3548: 3335:) in 1969, and the US patent for it was granted in 1974. It was approved by the US 3218: 3203: 3184: 3070: 2955: 2951: 2888: 2782: 2473: 1827: 1732: 1720: 1548: 1539:

The drug label advises that bupropion should not be prescribed to individuals with

1504: 1475: 1226: 1214: 879: 494: 432: 325: 82: 11022: 10519: 9995: 9922: 9708:

Brustolim D, Ribeiro-dos-Santos R, Kast RE, Altschuler EL, Soares MB (June 2006).

9208: 7894:"Suicidal antidepressant overdoses: a comparative analysis by antidepressant type" 7399: 7329: 7261: 6514:

Stahl SM, Pradko JF, Haight BR, Modell JG, Rockett CB, Learned-Coughlin S (2004).

5045: 4865: 4640: 3552: 27405: 27229: 27191: 27186: 26853: 26708: 26565: 26408: 26329: 25576: 25561: 25468: 25443: 25368: 25303: 25148: 25060: 24247: 24028: 23936: 23536: 23526: 23117: 22192: 21671: 20801: 20336: 20324: 20284: 20229: 19880: 19433: 19262: 19124: 19013: 18699: 18400: 17696: 17125: 16340: 16215: 16157: 16145: 15813: 15452: 15084: 15018: 14432: 14320: 14295: 14103: 14091: 13903: 13756: 13345: 13320: 13315: 13275: 13151: 13146: 13008: 12415: 12409: 12222: 11596: 11355: 11199: 11164: 11121: 11095: 9725: 8984: 7446: 7056: 7039: 6929: 6679: 6662: 6484: 6302: 5442: 5339: 5075: 4367: 3466: 3332: 3253: 3082: 3008: 2993: 2854: 1552: 1420: 1323: 1311: 1267: 1026: 464: 440: 204: 26768: 26763: 26758: 20879: 19393: 17642: 17027: 17019: 14162: 12596: 11484: 10210: 10193: 10055: 9709: 6180:"Pharmacological interventions for promoting smoking cessation during pregnancy" 5582: 4898: 1237:

that may be produced by other antidepressants. Bupropion is more effective than

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Strawbridge R, Izurieta E, Day E, Tee H, Young K, Tong CC, et al. (2023).

7594: 6965: 6629: 4569: 4198: 3587:

Fava M, Rush AJ, Thase ME, Clayton A, Stahl SM, Pradko JF, et al. (2005).

3165: 3154: 3077:

extended-release formulas to maintain a consistent concentration of bupropion.

2885: 2195: 1889: 1885: 1712: 1616: 1595: 1436: 1128:

are weak and clinical significance is contentious. Chemically, bupropion is an

1094: 1086: 1050: 305: 17031: 10946:"EMA advises companies on steps to take avoid nitrosamines in human medicines" 10250: 9960: 9675: 9416: 9399: 9369: 8897: 8448: 8063:

Todor I, Popa A, Neag M, Muntean D, Bocsan C, Buzoianu A, et al. (2016).

7835: 7676: 7501: 5714: 5697: 5199: 4821: 4129:

Patel K, Allen S, Haque MN, Angelescu I, Baumeister D, Tracy DK (April 2016).

1626:

The prescribing information warns about bupropion triggering an angle-closure

1262:

Prescribed as an aid for smoking cessation, bupropion reduces the severity of

27415: 27260: 27181: 26848: 26843: 26748: 26615: 26610: 26525: 26434: 26413: 26387: 26345: 26210: 25954: 25809: 25658: 25581: 25319: 24941: 24926: 24272: 24048: 23818: 23571: 23531: 23091: 22948: 22879: 22709: 22670: 22658: 21950: 21898: 21848: 21532: 21528: 21491: 21474: 21329: 21306: 20601: 20541: 20167: 20145: 20103: 20004: 19798: 19751: 19487: 19156: 18736: 18457: 18192: 17876: 17775: 17749: 17673: 17585: 17415: 17385: 17325: 17275: 17270: 17160: 17130: 17076: 16905: 16720: 16655: 16425: 16209: 16205: 16175: 16141: 16115: 16105: 16060: 16024: 15884: 15828: 15667: 15529: 15509: 15492: 15470: 15391: 15386: 15336: 15300: 15160: 15099: 14825: 14345: 14330: 14290: 14026: 13863: 13835: 13654: 13485: 13330: 13171: 13046: 12934: 12842: 12812: 12427: 12374: 12162: 12034: 12009: 12004: 11944: 11919: 11075: 10678: 10664: 9867:

Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse

9591: 9425: 9377: 9288: 9256: 7734: 7430: 6580: 5968: 5747:"Pharmacological Treatments for Patients with Treatment-Resistant Depression" 4694:

Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse

4146: 3762: 3730: 3414: 3410: 3328: 3241: 3200: 1873: 1854: 1792: 1772: 1748: 1657: 1630:

attack. On the other hand, bupropion may decrease the risk of development of

1575:, and in children, adolescents and young adults due to the increased risk of 1472: 1424: 1355: 1210: 1201: 1189: 1152: 975:

InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3

652: 407: 31: 23267: 14442: 14437: 9334: 8122: 8105: 7752: 7296: 6114: 6097: 5917: 5392: 4696:. Advances in Pharmacology. Vol. 69. Academic Press. pp. 177–216. 4014: 3997:

Masters AR, Gufford BT, Lu JB, Metzger IF, Jones DR, Desta Z (August 2016).

2861:

mg dose) in a PET study. Bupropion has also been shown to increase striatal

27270: 27255: 27206: 26975: 26644: 26605: 26520: 26398: 26353: 26301: 26242: 26200: 25939: 25586: 25364: 25359: 25309: 25290: 24966: 24462: 24447: 24427: 24402: 23838: 23731: 23581: 23473: 23468: 23388: 23363: 23135: 23121: 23095: 22990: 22980: 22891: 22871: 22824: 22765: 22662: 22575: 22560: 22545: 22492: 22476: 22372: 22297: 22264: 22082: 21964: 21878: 21726: 21558: 21394: 21389: 21349: 21301: 21255: 21239: 21089: 20883: 20683: 20533: 20393: 20328: 20235: 20221: 20193: 20181: 20123: 20074: 20064: 20034: 20014: 19989: 19934: 19905: 19895: 19850: 19818: 19806: 19802: 19786: 19731: 19397: 19317: 19167: 19040: 18838: 18822: 18756: 18572: 18551: 18518: 18473: 18335: 18280: 18180: 17904: 17821: 17767: 17757: 17500: 17430: 17425: 17340: 17150: 17140: 17091: 17072: 16870: 16790: 16780: 16360: 16255: 16245: 16070: 16065: 15909: 15879: 15767: 15637: 15515: 15427: 15396: 15351: 15346: 15341: 15185: 15155: 15043: 14952: 14912: 14815: 14735: 14625: 14615: 14427: 14422: 14407: 14402: 14381: 14086: 14012: 13980: 13840: 13827: 13524: 13480: 13350: 13295: 13290: 13176: 13111: 13041: 13026: 13003: 12985: 12628: 12472: 12460: 12370: 12277: 12207: 12197: 12049: 12039: 11939: 11934: 11857: 11852: 11832: 11817: 11771: 11533: 11497: 11439: 11363: 11207: 11172: 11129: 11030: 10268: 10170: 10030: 10003: 9930: 9892: 9808: 9733: 9683: 9645: 9609: 9552: 9509: 9474: 9342: 9307: 9216: 9178: 9138: 9076: 9041: 8992: 8941: 8933: 8905: 8644: 8595: 8577: 8538: 8530: 8499: 8456: 8416: 8350: 8315: 8266: 8231: 8188: 8131: 8090: 7973: 7927: 7853: 7770: 7721: 7708:"Naltrexone + bupropion (Mysimba). Too risky for only modest weight loss". 7694: 7637: 7602: 7566: 7509: 7454: 7407: 7304: 7269: 7234: 7165: 7116: 7065: 7024: 7005: 6973: 6937: 6902: 6789: 6737: 6688: 6647: 6598: 6549: 6492: 6457: 6405: 6370: 6321: 6262: 6244: 6213: 6164: 6155: 6138: 6123: 6082: 6033: 5976: 5936: 5885: 5833: 5782: 5723: 5674: 5600: 5551: 5502: 5475:

Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R (January 2008).

5461: 5424:

Turner EH, Cipriani A, Furukawa TA, Salanti G, de Vries YA (January 2022).

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combination may improve some measures of sexual function in women who have

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Selective serotonin reuptake inhibitors and serotonin receptor modulators:

11398: 10219: 10038: 9968: 9835: 9449:"Analgesic and anti-inflammatory activities of bupropion in animal models" 9248: 8870: 8835: 8800: 8765: 8008: 7097: 7080: 6397: 4321: 4183:"Clinicians' Views on Treatment-Resistant Depression: 2016 Survey Reports" 3301:

This diagram shows the synthesis of bupropion via 3'-chloro-propiophenone.

2973: 61: 44: 27219: 27196: 26868: 26625: 26590: 26560: 26490: 26485: 26460: 26358: 26261: 25914: 25904: 25884: 25838: 25819: 25799: 25778: 25566: 25551: 25486: 25438: 25378: 25349: 25329: 25295: 25223: 25017: 24951: 24497: 24477: 24467: 24432: 24392: 24292: 24223: 24188: 24183: 24173: 24005: 23941: 23896: 23891: 23726: 23686: 23601: 23591: 23566: 23483: 23438: 23403: 23081: 23073: 22984: 22976: 22972: 22952: 22940: 22931: 22911: 22899: 22883: 22867: 22705: 22635: 22580: 22550: 22496: 22484: 22368: 22364: 22293: 22214: 22047: 21954: 21931: 21926: 21915: 21873: 21853: 21828: 21813: 21775: 21589: 21554: 21503: 21495: 21469: 21419: 21409: 21359: 21353: 21345: 21341: 21316: 21271: 21263: 21243: 21231: 21218: 21213: 21182: 21040: 20964: 20786: 20740: 20718: 20668: 20658: 20648: 20617: 20577: 20573: 20565: 20545: 20529: 20520: 20424: 20373: 20269: 20201: 20185: 20157: 20149: 20095: 20083: 20054: 20049: 20039: 20019: 19954: 19949: 19938: 19930: 19926: 19870: 19866: 19858: 19842: 19838: 19826: 19822: 19810: 19794: 19759: 19741: 19581: 19499: 19491: 19309: 19305: 19200: 19196: 19102: 18981: 18965: 18904: 18856: 18834: 18830: 18826: 18814: 18806: 18740: 18680: 18676: 18615: 18596: 18514: 18506: 18448: 18418: 18385: 18371: 18260: 18249: 18220: 18165: 18161: 18019: 18009: 17949: 17880: 17867: 17862: 17842: 17817: 17795: 17779: 17733: 17724: 17719: 17605: 17570: 17550: 17465: 17455: 17410: 17390: 17310: 17240: 17230: 17220: 17215: 17185: 16975: 16970: 16960: 16950: 16895: 16860: 16850: 16845: 16840: 16830: 16770: 16745: 16740: 16660: 16430: 16420: 16365: 16336: 16286: 16230: 16183: 16165: 16100: 16080: 16029: 16019: 15994: 15954: 15949: 15894: 15864: 15843: 15833: 15823: 15783: 15722: 15702: 15692: 15672: 15652: 15612: 15602: 15549: 15478: 15460: 15432: 15417: 15376: 15356: 15305: 15295: 15270: 15230: 15225: 15170: 15140: 15119: 15109: 15094: 15059: 15023: 14988: 14917: 14907: 14897: 14892: 14840: 14820: 14810: 14785: 14765: 14695: 14670: 14645: 14640: 14635: 14600: 14595: 14553: 14548: 14497: 14305: 14109: 14066: 14061: 14031: 13976: 13928: 13888: 13802: 13797: 13777: 13772: 13644: 13580: 13575: 13505: 13495: 13490: 13475: 13464: 13459: 13389: 13360: 13355: 13285: 13255: 13224: 13199: 13161: 13116: 13076: 13066: 13036: 13031: 12929: 12683: 12633: 12390: 12287: 12152: 12087: 12082: 12072: 12029: 12014: 11999: 11989: 11959: 11949: 11822: 11792: 11787: 11733: 11710: 11705: 11677: 11634: 11611: 11601: 11543: 11449: 11266:(2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. 11089:

Antidepressant Wellbutrin becomes 'poor man's cocaine' on Toronto streets

9707: 8258: 7661:"A review of systemic medications that may modulate the risk of glaucoma" 6702:

Razali NA, Sidi H, Choy CL, Ross NA, Baharudin A, Das S (February 2022).

6531: 6046: 5666: 5515: 5493: 5476: 4746:"Bupropion for attention deficit hyperactivity disorder (ADHD) in adults" 4744:

Verbeeck W, Bekkering GE, Van den Noortgate W, Kramers C (October 2017).

4743: 4405: 3604: 3098: 2451: 1858: 1834: 1823: 1819: 1804: 1760: 1704: 1568: 1368: 1319: 1307: 1283: 1242: 1205: 1038: 212: 11342:

Schneier FR (March 2011). "Pharmacotherapy of social anxiety disorder".

10194:"Bupropion metabolites produce false-positive urine amphetamine results" 10083: 8179: 6137:

Selph S, Patnode C, Bailey SR, Pappas M, Stoner R, Chou R (April 2020).

5113: 2996:

of bupropion is unknown but is presumed to be low, at 5–20%, due to the

1803:

have been shown to decrease levels of bupropion and/or its metabolites.

1196:

for the treatment of depression. Some peer-reviewed studies suggest the

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Committee for Medicinal Products for Human Use (CHMP) (23 March 2017).

10877:

Committee for Medicinal Products for Human Use (CHMP) (24 March 2017).

10303: 9848:

Review of bupropion, S G Bryant, B G Guernsey, N B Ingrim, PMID 6140095

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mg/day) and its metabolites in the human brain as measured by several

1656:

The FDA requires all antidepressants, including bupropion, to carry a

1471:

in a number of different formulations. It is formulated mostly as the

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Pandhare A, Pappu AS, Wilms H, Blanton MP, Jansen M (February 2017).

8342: 8297: 6989:"Antidepressants and inflammatory bowel disease: a systematic review" 5178: 4552:

De Vries C, Gadzhanova S, Sykes MJ, Ward M, Roughead E (March 2021).

3004: 1862: 1800: 1784: 1716: 1680: 1401: 1343: 1315: 1106: 1098: 1058: 669: 574: 473: 198: 35: 11721: 11574: 10709:"Drug Approval Package: Aplenzin (Bupropion Hydrobromide) NDA 22108" 8081: 8064: 3263:

to give bupropion as the hydrochloride salt in 75–85% overall yield.

1845:

effects of MDMA. Interactions with other CYP2D6 substrates, such as

27127: 27117: 27112: 27107: 27064: 27000: 26995: 26970: 26950: 26935: 26930: 26833: 26580: 26426: 26266: 26247: 26077: 26067: 26011: 26006: 25944: 25814: 25804: 25794: 25571: 25463: 25388: 24936: 24452: 24407: 24297: 24257: 24252: 24168: 24015: 23876: 23508: 23503: 23493: 23155: 23151: 23129: 23125: 22936: 22915: 22780: 22701: 22684: 22378: 22356: 22340: 22289: 22210: 21940: 21833: 21754: 21704: 21694: 21585: 21550: 21546: 21514: 21321: 21275: 21168: 20980: 20956: 20909: 20782: 20605: 20593: 20495: 20369: 20320: 20307: 20261: 20197: 20189: 20118: 19910: 19890: 19874: 19736: 19701: 19507: 19475: 19423: 19353: 19289: 19285: 19160: 19152: 19106: 19098: 19036: 18994: 18990: 18986: 18900: 18797: 18767: 18732: 18684: 18672: 18611: 18453: 18433: 18428: 18381: 18245: 18235: 18216: 18126: 18116: 18106: 18039: 17959: 17939: 17914: 17892: 17872: 17852: 17813: 17559: 17485: 17300: 17290: 17110: 16865: 16855: 16815: 16810: 16800: 16765: 16715: 16710: 16615: 16454: 16405: 16395: 16294: 16240: 16201: 16179: 15969: 15959: 15752: 15545: 15488: 15474: 15245: 15235: 14937: 14922: 14887: 14745: 14740: 14730: 14700: 14502: 14259: 14076: 13991: 13970: 13954: 13936: 13913: 13873: 13782: 13664: 13585: 13310: 13250: 13156: 13121: 13106: 13071: 12922: 12907: 12847: 12800: 12760: 12755: 12623: 12618: 12147: 12103: 11827: 11812: 11655: 11288:"Autorisation – ZYBAN L.P. 150 mg, comprimé à libération prolongée" 10682: 10573: 9904: 9902: 7213:

Marin RS, Wilkosz PA (2005). "Disorders of diminished motivation".

6986: 3003:

Bupropion is metabolized in the body by a variety of pathways. The

2959: 1756: 1673: 1627: 1598:. It is also associated with about 20% increased risk of headache. 1540: 1372: 1125: 1102: 1070: 1029:

medication in the cases of "incomplete response" to the first-line

791: 783: 714: 240: 24522: 11405: 11229: 10408:"Drug Approval Package: Wellbutrin XL (Bupropion HCI) NDA #021515" 7187:

Novel approaches towards pharmacological enhancement of motivation

6334: 1396:, there have been suggestions that it might be useful in treating 932: 27097: 27059: 27041: 27005: 26965: 26945: 26925: 26667: 26620: 26585: 26515: 26276: 25678: 25643: 25324: 25248: 25233: 24879: 24844: 24834: 24824: 24819: 24814: 24804: 24098: 24078: 24073: 23980: 23916: 23681: 23656: 23651: 23646: 23641: 23636: 23631: 23576: 23393: 23358: 22926: 22820: 22775: 22666: 22525: 22520: 22515: 22510: 22436: 21921: 21785: 21744: 21509: 21434: 21187: 20996: 20843: 20761: 20069: 19999: 19969: 19523: 19358: 19347: 19281: 19188: 19051: 18802: 18498: 18310: 18300: 18290: 18049: 18044: 17934: 17555: 17535: 17115: 17086: 16940: 16935: 16930: 16925: 16915: 16819: 16705: 16640: 16635: 16260: 16090: 16043: 16039: 15989: 15984: 15939: 15929: 15889: 15818: 15697: 15366: 15319: 15315: 15265: 15260: 15215: 15205: 15165: 15089: 15008: 14770: 14760: 14750: 14720: 14665: 14487: 14482: 14477: 14472: 14467: 14462: 14457: 14417: 14315: 14234: 14131: 14099: 13878: 13845: 13444: 13233: 13051: 11969: 11411: 10663:

This article incorporates text from this source, which is in the

5849: 5312: 4802:. In Nemeroff CB, Schatzberg AF, Rasgon N, Strakowski SM (eds.). 3867:"Wellbutrin XL- bupropion hydrochloride tablet, extended release" 3340: 3138: 3029: 2936: 2895: 2800: 1869: 1669: 1608: 1193: 1090: 1074: 1054: 10108: 9899: 9194: 6614:"Evaluation and Management of Hypoactive Sexual Desire Disorder" 3240:

It is synthesized in two chemical steps starting from 3'-chloro-

27137: 26985: 26980: 26955: 26723: 26703: 26535: 26455: 26320: 26311: 26252: 25755: 25673: 25663: 25653: 25638: 25628: 25623: 25228: 25128: 24931: 24909: 24904: 24784: 24779: 24774: 24759: 24754: 24749: 24724: 24689: 24684: 24679: 24674: 24669: 24664: 24659: 24083: 24068: 23985: 23946: 23911: 23788: 23706: 23701: 23666: 23626: 23328: 22800: 22590: 22416: 22412: 22153: 21197: 21046: 20972: 20960: 20839: 20835: 19664: 19587: 19495: 19483: 19479: 19443: 19343: 19339: 18340: 17145: 16965: 16775: 16560: 16270: 15999: 15944: 15687: 15525: 15275: 15220: 15028: 14775: 14452: 12806: 11693:

Tooltip Noradrenergic and specific serotonergic antidepressants

11516: 11431:

10.1002/1520-6394(2000)12:2<111::AID-DA9>3.0.CO;2-3

10145:"Amphetamine positive toxicology screen secondary to bupropion" 9860: 9858: 9856: 9854: 9190: 9188: 7986: 6095: 5998:

Rosen LJ, Galili T, Kott J, Goodman M, Freedman LS (May 2018).

5258: 4465: 4463: 4461: 3365: 3045: 3041: 3012: 2164: 1888:. The prescribing information recommends minimizing the use of 1811: 1736: 1416: 1412: 1078: 1062: 1037:, and it is more effective than SSRIs at improving symptoms of 822: 477: 10817:

Drug Safety Communication – Mental Health Side Effects Revised

10516:"Seasonal affective disorder drug Wellbutrin XL wins approval" 10162:

10.1002/1520-6394(2000)12:1<53::AID-DA8>3.0.CO;2-4

9864: 9762:

Goodman and Gilman's The Pharmacological Basis of Therapeutics

9054: 8966: 8964: 8962: 8960: 8848: 7428: 7129: 5802:

International Journal of Chronic Obstructive Pulmonary Disease

4800:"Other Antidepressants: Bupropion, Mirtazapine, and Trazodone" 4691: 4429: 1707:

are the two new generation antidepressants (that is excluding

52: 26570: 25728: 25648: 25618: 25168: 25118: 25113: 24986: 24914: 24739: 24704: 24644: 24629: 24043: 23970: 23621: 23323: 22795: 22790: 22037: 21958: 19659: 19612: 17994: 17515: 13674: 11884: 11370: 8477: 8155: 8103: 5651: 5423: 5374: 5127: 4390: 3837:"Wellbutrin SR – bupropion hydrochloride tablet, film coated" 3666:"TGA eBS – Product and Consumer Medicine Information Licence" 2913: 1334:

Bupropion is less likely than other antidepressants to cause

1175: 923: 802: 596: 579: 469: 91: 9851: 9185: 9059:. New Perspectives in Neurotransmitter Transporter Biology. 8970: 8778: 7037: 6660: 6520:

Primary Care Companion to the Journal of Clinical Psychiatry

6275: 6177: 5474: 4458: 3900:"Aplenzin – bupropion hydrobromide tablet, extended release" 3593:

Primary Care Companion to the Journal of Clinical Psychiatry

1326:, which have an immediate onset of effect in the condition. 847: 27147: 26082: 25713: 25668: 25633: 25133: 25123: 24919: 24744: 24729: 24719: 24709: 24699: 24694: 24654: 24649: 24639: 24634: 24619: 24599: 24020: 23513: 22424: 21032: 20831: 20827: 20823: 20416: 19573: 19335: 19331: 19327: 18295: 16344: 13131: 11754: 9908: 9393: 9391: 9005: 8957: 7615: 7241: 5076:"Bupropion Drug Usage Statistics, United States, 2013–2022" 4931:

Dye LR, Murphy C, Calello DP, Levine MD, Skolnik A (2017).

4551: 3538: 2024: 1895:

Caution should be observed when combining bupropion with a

1892:, since in rare cases bupropion reduces alcohol tolerance. 1838: 1830:(a drug that is mainly metabolized by CYP2D6) to its major 1339: 1293: 774: 109: 103: 27:

Medication mainly used for depression and smoking cessation

14866: 11622: 9355: 8842: 8807: 7429:

Alberti S, Chiesa A, Andrisano C, Serretti A (June 2015).

6869:"The search for medications to treat stimulant dependence" 5313:

Hengartner MP, Jakobsen JC, Sørensen A, Plöderl M (2020).

3831: 3829: 3827: 3825: 3823: 3821: 3819: 3817: 3815: 3199:

of 3.6. Pharmaceutically, bupropion is used mainly as the

1703:, adjusted for the number of prescriptions, bupropion and 112: 26555: 22784: 22360: 22222: 20992: 20934: 20347: 19519: 19448: 18752: 17896: 16573: 11316: 10281: 9942: 9940: 9397: 9349: 8608: 8110:

The Journal of Pharmacology and Experimental Therapeutics

7817: 7282: 6611: 5099: 4619: 4180: 4048: 4003:

The Journal of Pharmacology and Experimental Therapeutics

3644: 3433:

Bupropion has been studied limitedly in the treatment of

2902:

receptor activation. They are enhanced and inhibited by σ

88: 16315: 14151:

Drugs for erectile dysfunction and premature ejaculation

13752: 11376: 10374:"Bupropion helps people with schizophrenia quit smoking" 9975: 9574:

Chen WC, Lai HC, Su WP, Palani M, Su KP (January 2015).

9487: 9388: 9320: 8918: 8772: 8515: 8328: 8279: 8209: 7659:

Wu A, Khawaja AP, Pasquale LR, Stein JD (January 2020).

7530: 7247: 6136: 6049:"Relapse prevention interventions for smoking cessation" 5798:"The use of bupropion SR in cigarette smoking cessation" 4128: 2898:. Its antidepressant-like effects in rodents depend on σ 2690: 2669: 2647: 2621: 2591: 2561: 2531: 2501: 23379: 12976: 12590: 11185: 9314: 9233: 8380: 7276: 6513: 4469: 3996: 3859: 3812: 1644:

Bupropion has rarely been associated with instances of

1165:

World Health Organization's List of Essential Medicines

26636: 16996: 16592: 15857:

Serotonin–norepinephrine–dopamine reuptake inhibitors:

15133:

Serotonin–norepinephrine–dopamine reuptake inhibitors:

10016: 9937: 9785: 9758: 9227: 8912: 7658: 7579: 7487: 7078: 6226: 5997: 5899:

Wu P, Wilson K, Dimoulas P, Mills EJ (December 2006).

5565:

Li DJ, Tseng PT, Chen YW, Wu CK, Lin PY (March 2016).

4930: 1486:

mg), SR (sustained-release) tablets (50, 100, 150, 200

27389: 24021: 23514: 15576: 10848:"Glaxo agrees to pay $ 3 billion in fraud settlement" 10232: 10192:

Nixon AL, Long WH, Puopolo PR, Flood JG (June 1995).

10191: 9765:(12th ed.). New York: McGraw-Hill Professional. 9661: 9098: 9096: 9094: 8813: 5898: 4181:

Arandjelovic K, Eyre HA, Lavretsky H (October 2016).

3894: 3892: 3244:. The alpha position adjacent to the ketone is first 1563:. It should be avoided in individuals who are taking 1490:

mg), and XL (extended-release) tablets (150, 300, 450

135: 125: 115: 14213: 11726:

Tooltip Serotonin antagonist and reuptake inhibitors

11579:

Tooltip Serotonin–norepinephrine reuptake inhibitors

10508: 10233:

Casey ER, Scott MG, Tang S, Mullins ME (June 2011).

10084:"Bupropion: Uses, Interactions, Mechanism of Action" 9752: 9269: 9152: 9150: 9148: 8745: 8722: 8720: 8062: 7818:

Henssler J, Heinz A, Brandt L, Bschor T (May 2019).

7038:

Thorkelson G, Bielefeldt K, Szigethy E (June 2016).

6421: 4851: 4085:(37th ed.). Pharmaceutical Press. p. 402. 3586: 3266: 106: 100: 97: 85: 27452:

Attention deficit hyperactivity disorder management

24204: 12060: 11660:

Tooltip Norepinephrine–dopamine reuptake inhibitors

11008: 9981: 7951: 7891: 7384: 7190:(Thesis). University of Cambridge. pp. 13–14. 6993:

Clinical Practice and Epidemiology in Mental Health

6764:"Meta-analysis: pharmacologic treatment of obesity" 6612:Clayton AH, Kingsberg SA, Goldstein I (June 2018). 3629: 3069:of 12–30 hours), while the effective doses of 1423:. Accordingly, the drug has been found to increase 702: 94: 14855: 12670: 10632: 10630: 10628: 10378:National Institute on Drug Abuse Research Findings 9446: 9091: 8877: 8037:. U.S. Food and Drug Administration. August 2020. 7356:"Bupropion/Dextromethorphan – Axsome Therapeutics" 7348: 6830: 6761: 6701: 6386:Journal of Child and Adolescent Psychopharmacology 5744: 3889: 3459: 3137:-butylcathinone. The clinically used bupropion is 2298: 1089:is notable. Rare but serious side effects include 24149: 23857: 17672: 14192: 11902: 11321:(69 ed.). London, UK: Pharmaceutical Press. 10102: 9946: 9869:. Adv Pharmacol. Vol. 69. pp. 177–216. 9145: 8717: 8656: 8654: 8069:Journal of Pharmacy & Pharmaceutical Sciences 8022: 8020: 8018: 7869:The Maudsley prescribing guidelines in psychiatry 7866: 7820:"Antidepressant Withdrawal and Rebound Phenomena" 7079:Eskeland S, Halvorsen JA, Tanum L (August 2017). 6422:Wilens TE, Morrison NR, Prince J (October 2011). 5845: 5843: 4793: 4791: 4789: 4280: 4234: 27413: 12125: 11004: 11002: 9703: 9701: 9657: 9655: 9530: 8511: 8509: 8430: 8428: 8426: 8376: 8374: 8372: 8370: 8368: 8151: 8149: 7947: 7945: 7943: 7941: 7939: 7937: 7206: 7132:"Antidepressants for non-specific low back pain" 6950: 4307: 4124: 4122: 2741: 1810:Bupropion and its metabolites are inhibitors of 682: 27311:GlaxoSmithKline Services Unlimited v Commission 12462: 11521:Tooltip Selective serotonin reuptake inhibitors 10625: 10142: 10115:. Medpharm Scientific Publishers. p. 173. 9573: 8751: 7892:White N, Litovitz T, Clancy C (December 2008). 7179: 7177: 7175: 6757: 6755: 6417: 6415: 5950: 5948: 5946: 5647: 5645: 5370: 5368: 5308: 5306: 5304: 5254: 5252: 5250: 5174: 5172: 5170: 5168: 4847: 4845: 4843: 4739: 4737: 4735: 4733: 4731: 4729: 4687: 4685: 4683: 4681: 4615: 4613: 4611: 4609: 4607: 4547: 4545: 4503: 4501: 4425: 4423: 4386: 4384: 4355: 4353: 4351: 4349: 4347: 4276: 4274: 4176: 4174: 4120: 4118: 4116: 4114: 4112: 4110: 4108: 4106: 4104: 4102: 3992: 3990: 3959: 3957: 3955: 3534: 3532: 3530: 3528: 3526: 3524: 3522: 3520: 3518: 3516: 3514: 3512: 3121:-butyl-β-keto-α-methylphenethylamine, 3-chloro- 2992:of 3 hours and 5 hours, respectively. Absolute 2745: 1109:may be associated with increased likelihood of 1053:of bupropion with the greatest difference from 645: 24159: 23867: 17491:Trimetaphan camsilate (trimethaphan camsylate) 11045: 11011:The American Journal of Drug and Alcohol Abuse 10367: 10365: 8651: 8559: 8015: 7332:. United States Food and Drug Administration. 6470: 5954: 5840: 4893: 4891: 4806:. American Psychiatric Pub. pp. 365–374. 4786: 3582: 3580: 3578: 3510: 3508: 3506: 3504: 3502: 3500: 3498: 3496: 3494: 3492: 2946:Bupropion has been found to have a mixture of 1912:Pharmacology of bupropion and its metabolites 27527:World Health Organization essential medicines 26652: 24538: 23297: 23283: 20080:Serotonin antagonists and reuptake inhibitors 17658: 17632:Acetylcholine metabolism/transport modulators 16546: 15781:Serotonin–norepinephrine reuptake inhibitors: 15565: 15057:Serotonin–norepinephrine reuptake inhibitors: 14885:Selective norepinephrine reuptake inhibitors: 14178: 13738: 12962: 12576: 11465: 11335: 11179: 11150: 10999: 10845: 10136: 9779: 9698: 9652: 9616: 9567: 9524: 9481: 9440: 9263: 9102: 8999: 8948: 8883: 8693: 8691: 8506: 8471: 8434: 8423: 8365: 8322: 8273: 8238: 8203: 8146: 8097: 7934: 7811: 5745:Ruberto VL, Jha MK, Murrough JW (June 2020). 5695: 5564: 2921:Tooltip half-maximal inhibitory concentration 2349: 1519:mg extended-release tablets) for obesity and 17627:Muscarinic acetylcholine receptor modulators 14971:Norepinephrine–dopamine reuptake inhibitors: 14202: 11414:"Bupropion-SR in treatment of social phobia" 10185: 10078: 10076: 9815: 9156: 7980: 7728: 7701: 7652: 7609: 7573: 7524: 7481: 7422: 7378: 7324: 7322: 7320: 7318: 7316: 7314: 7212: 7172: 7123: 7072: 7031: 6980: 6909: 6860: 6752: 6695: 6654: 6605: 6556: 6507: 6464: 6412: 6377: 6328: 6269: 6220: 6171: 6130: 6089: 5943: 5892: 5738: 5689: 5642: 5558: 5509: 5468: 5417: 5365: 5301: 5247: 5165: 5121: 5000: 4998: 4840: 4726: 4678: 4604: 4542: 4507: 4498: 4420: 4381: 4344: 4271: 4187:The American Journal of Geriatric Psychiatry 4171: 4099: 3987: 3952: 3157:on bupropion can be separated, they rapidly 3113:. It is also known structurally as 3-chloro- 2247: 1442:Bupropion has been used in the treatment of 244: 27492:Norepinephrine–dopamine reuptake inhibitors 12496: 12313: 12253: 11759:Tooltip Serotonin modulator and stimulators 10679:"FDA Approvals: Advair, Relistor, Aplenzin" 10362: 10112:Index Nominum: International Drug Directory 10050: 10048: 7786: 7136:The Cochrane Database of Systematic Reviews 6915: 6562: 6184:The Cochrane Database of Systematic Reviews 6053:The Cochrane Database of Systematic Reviews 5856:The Cochrane Database of Systematic Reviews 5522:The Cochrane Database of Systematic Reviews 4970: 4968: 4966: 4888: 4750:The Cochrane Database of Systematic Reviews 3692:Brazilian Health Regulatory Agency (Anvisa) 3575: 3489: 2431: 2405: 1204:report that bupropion has an at-most small 628:-Butylamino)-1-(3-chlorophenyl)propan-1-one 424:In general: ℞ (Prescription only) 26659: 26645: 24545: 24531: 23290: 23276: 17665: 17651: 16553: 16539: 14871:Tooltip Norepinephrine reuptake inhibitors 14185: 14171: 13745: 13731: 12969: 12955: 12886: 12780: 12740: 12640: 12583: 12569: 11627:Tooltip Norepinephrine reuptake inhibitors 11479: 11472: 11458: 10442:"Drug Approval Package: Zyban NDA# 020711" 8688: 8674:Psychoactive Drug Screening Program (PDSP) 5209:11370/842b1441-d0f3-4797-b95b-3a6a72262150 4926: 4924: 4797: 4629:The World Journal of Biological Psychiatry 4230: 4228: 4226: 4135:Therapeutic Advances in Psychopharmacology 2977:Principal pathways of bupropion metabolism 2767:norepinephrine–dopamine reuptake inhibitor 1118:norepinephrine–dopamine reuptake inhibitor 861: 742: 16578:Tooltip Nicotinic acetylcholine receptors 11429: 11222: 11065: 11051: 10974: 10569:"Report questions generic antidepressant" 10258: 10209: 10160: 10109:Schweizerischer Apotheker-Verein (2004). 10073: 9759:Brunton L, Chabner B, Knollman B (2010). 9599: 9464: 9415: 9297: 9287: 9128: 9031: 8634: 8585: 8406: 8305: 8178: 8121: 8080: 7917: 7860: 7843: 7760: 7684: 7556: 7311: 7155: 7106: 7096: 7055: 7014: 7004: 6892: 6873:Addiction Science & Clinical Practice 6779: 6727: 6678: 6637: 6588: 6539: 6447: 6360: 6311: 6301: 6252: 6203: 6154: 6113: 6072: 6023: 5991: 5926: 5916: 5875: 5823: 5813: 5772: 5762: 5713: 5590: 5541: 5492: 5451: 5441: 5400: 5348: 5338: 5284: 5207: 5112: 4995: 4769: 4525: 4206: 4154: 4065: 4022: 3782: 3612: 1444:postural orthostatic tachycardia syndrome 762: 17121:Candocuronium iodide (chandonium iodide) 16320:Tooltip Vesicular monoamine transporters 15595:Selective serotonin reuptake inhibitors: 12354: 11341: 11107: 10735: 10534: 10045: 9821: 9270:Pei Y, Asif-Malik A, Canales JJ (2016). 8244: 7183: 4963: 4361:"Wellbutrin XL® Prescribing Information" 4080: 4044: 4042: 3314: 3252:of the resulting alpha-bromoketone with 2972: 2695:Tooltip human Ether-à-go-go-Related Gene 1300:attention deficit hyperactivity disorder 1294:Attention deficit hyperactivity disorder 1174: 27304:Christopher v. SmithKline Beecham Corp. 23419:Dehydroepiandrosterone sulfate (DHEA-S) 23384:Tooltip Calcitonin gene-related peptide 10823:(FDA). 16 December 2016. Archived from 10676: 10566: 10371: 8660: 7330:"Drugs@FDA: FDA Approved Drug Products" 6866: 6781:10.7326/0003-4819-142-7-200504050-00012 5852:"Antidepressants for smoking cessation" 5613: 5093: 4921: 4223: 4083:Martindale: The Complete Drug Reference 3038:11β-hydroxysteroid dehydrogenase type 1 2779:norepinephrine–dopamine releasing agent 1689:antidepressant discontinuation syndrome 1298:In the United States, the treatment of 1239:selective serotonin reuptake inhibitors 857: 722: 217: 14: 27414: 17001:Tooltip negative allosteric modulators 16597:Tooltip positive allosteric modulators 10560: 8331:Clinical Pharmacology and Therapeutics 8286:Clinical Pharmacology and Therapeutics 7989:Journal of Clinical Psychopharmacology 7782: 7780: 7435:Journal of Clinical Psychopharmacology 7366:from the original on 21 September 2021 6473:Journal of Clinical Psychopharmacology 5795: 4074: 3390: 3129:-butyl-β-ketoamphetamine, or 3-chloro- 1031:selective serotonin reuptake inhibitor 416: 388: 26779:Recherche et Industrie Thérapeutiques 26640: 24526: 23271: 17646: 16534: 15581:Tooltip Serotonin reuptake inhibitors 14166: 13726: 12950: 12564: 12449: 12353: 12124: 11883: 11496: 11453: 11261: 10956:from the original on 11 November 2023 10648:from the original on 13 December 2019 10318:"Wellbutrin entry in the Orange Book" 8728:"Bupropion – Biological Test Results" 7336:from the original on 16 November 2016 5235:from the original on 27 February 2022 5107:. Geneva: World Health Organization. 5026:from the original on 27 November 2020 4974: 4039: 3971:. GlaxoSmithKline UK. 1 August 2013. 3477:from the original on 24 December 2018 3292: 3287: 3055:and by yet unknown enzyme leading to 2022: 1972: 1329: 830: 810: 401: 235: 203: 169:-butyl-β-keto-α-methylphenethylamine; 21594:methylergometrine (methylergonovine) 20554:N-desalkylquetiapine (norquetiapine) 20390:methylergometrine (methylergonovine) 19536:methylergometrine (methylergonovine) 19165:methylergometrine (methylergonovine) 19111:methylergometrine (methylergonovine) 18470:methylergometrine (methylergonovine) 17901:methylergometrine (methylergonovine) 14218:Tooltip Dopamine reuptake inhibitors 11310: 11255: 10987:from the original on 11 October 2023 10926:from the original on 19 January 2021 10889:from the original on 26 October 2020 10846:Thomas K, Schmidt MS (2 July 2012). 10496:from the original on 1 November 2020 10456:from the original on 5 December 2019 10422:from the original on 5 December 2019 10010: 9740:from the original on 16 October 2023 9533:Naunyn-Schmiedeberg's Arch Pharmacol 9103:Sałaciak K, Pytka K (January 2022). 8560:Stuebler AG, Jansen M (March 2020). 8044:from the original on 19 October 2020 7867:Taylor D, Carol P, Shitij K (2012). 4983:from the original on 7 November 2017 3910:from the original on 26 October 2020 3672:from the original on 7 December 2016 3282: 3032:leading to 4'-hydroxybupropion. The 2724:nM at a variety of other sites (5-HT 1534: 1383:(FDA) for the treatment of obesity. 1257: 1163:million prescriptions. It is on the 324: 26694:GlaxoSmithKline Pharmaceuticals Ltd 26551:Lysergic acid 2,4-dimethylazetidide 24552: 24209:Tooltip 3,4,5-Trimethoxyamphetamine 20558:N-desmethylclozapine (norclozapine) 12065:Tooltip Tetracyclic antidepressants 10723:from the original on 15 August 2020 10518:. CNN. 14 June 2006. Archived from 8437:Cellular and Molecular Neurobiology 7777: 5056:from the original on 30 August 2024 4951:from the original on 29 August 2021 3940:from the original on 18 August 2022 3877:from the original on 9 January 2023 3800:from the original on 9 January 2023 3770:from the original on 9 January 2023 3738:from the original on 9 January 2023 3409:In Russia bupropion is banned as a 3395: 3206:but also to a lesser extent as the 2968: 2884:Bupropion has been claimed to be a 2221: 1543:or other conditions that lower the 1499:mg, equivalent to 150, 300, and 450 1478:but also to a lesser extent as the 790: 782: 673: 24: 15915:Didesmethylsibutramine (BTS-54505) 15191:Didesmethylsibutramine (BTS-54505) 14860:Tooltip Norepinephrine transporter 14621:Didesmethylsibutramine (BTS-54505) 11317:Joint Formulary Committee (2015). 11240:from the original on 20 April 2013 10749:(FDA). 1 July 2009. Archived from 10542:"Generic drug equality questioned" 10350:from the original on 6 August 2013 9875:10.1016/B978-0-12-420118-7.00005-6 9638:10.1016/j.transproceed.2013.04.010 8247:The Journal of Clinical Psychiatry 7824:Deutsches Ärzteblatt International 7741:Postepy Dermatologii I Alergologii 7583:The Canadian Journal of Cardiology 7362:. Springer Nature Switzerland AG. 6428:Expert Review of Neurotherapeutics 6383: 5957:Expert Review of Neurotherapeutics 5696:Naguy A, Badr BHM (October 2022). 5655:The Journal of Clinical Psychiatry 4702:10.1016/B978-0-12-420118-7.00005-6 4514:The American Journal of Psychiatry 4484:10.1016/j.genhosppsych.2011.07.001 4432:The American Journal of Psychiatry 4394:The Journal of Clinical Psychiatry 4283:The Journal of Clinical Psychiatry 3706:from the original on 3 August 2023 3413:, due to it being a derivative of 2836:muscarinic acetylcholine receptors 2303:Tooltip Norepinephrine transporter 1731:Since bupropion is metabolized to 1449: 1409:disorders of diminished motivation 1188:The evidence overall supports the 25: 27538: 27318:United States v. Glaxo Group Ltd. 24383:Chlorphenamine (chlorpheniramine) 24154:Tooltip N,N-Diisopropyltryptamine 23862:Tooltip N,N-Diisopropyltryptamine 17206:Dimethyltubocurarine (metocurine) 14433:Etybenzatropine (ethybenztropine) 12450: 11907:Tooltip Tricyclic antidepressants 11298:from the original on 9 April 2023 10858:from the original on 2 March 2017 10544:. 12 October 2007. Archived from 10346:. eMedExpert.com. 31 March 2008. 9447:Hajhashemi V, Khanjani P (2014). 7469:from the original on 8 March 2023 7184:Hailwood JM (27 September 2018). 6720:10.2174/1570159X20666220222145735 4909:from the original on 29 July 2018 4828:from the original on 8 March 2023 4592:from the original on 7 March 2023 4508:Nelson JC, Spyker DA (May 2017). 3975:from the original on 20 July 2017 2941:trace amine-associated receptor 1 2879:norepinephrine reuptake inhibitor 2775:nicotinic acetylcholine receptors 1679:In rare cases, bupropion-induced 1589:List of side effects of bupropion 1407:Bupropion has been used to treat 1348:hypoactive sexual desire disorder 1241:(SSRIs) at improving symptoms of 955:O=C(C(C)NC(C)(C)C)C1=CC=CC(Cl)=C1 351: 267: 27399: 27372: 27371: 27325:United States v. GlaxoSmithKline 16562:Nicotinic acetylcholine receptor 15905:Desmethylsibutramine (BTS-54354) 15181:Desmethylsibutramine (BTS-54354) 14611:Desmethylsibutramine (BTS-54354) 12843:Hydromorphone (extended-release) 11391:10.1097/00004714-199108000-00023 11319:British National Formulary (BNF) 11280: 11144: 11101: 11082: 10975:Lipanovic D (6 September 2023). 10968: 10938: 10901: 10870: 10839: 10805: 10765: 10701: 10689:from the original on 6 July 2022 10670: 10658: 10468: 10434: 10400: 10336: 10310: 10275: 10226: 9842: 9801:10.1097/00008571-200404000-00002 9171:10.1111/j.1472-8206.2008.00605.x 9069:10.1016/j.neuropharm.2005.05.004 9048: 9024:10.1016/j.neuroimage.2009.11.077 8627:10.1016/j.neuropharm.2016.09.021 8602: 8553: 8480:European Journal of Pharmacology 8056: 8001:10.1097/00004714-199510000-00004 7885: 7871:. West Sussex: Wiley-Blackwell. 7630:10.2165/00002018-200225020-00004 7388:Expert Opinion on Emerging Drugs 7227:10.1097/00001199-200507000-00009 6918:European Journal of Pharmacology 6848:from the original on 4 June 2020 6818:from the original on 4 June 2020 4249:10.2165/00003495-200868050-00011 3847:from the original on 4 June 2020 3726:"Wellbutrin Product information" 3467:"Bupropion Use During Pregnancy" 3274: 3161:under physiological conditions. 1009:, and sold under the brand name 899: 896: 890: 81: 60: 51: 27482:Female sexual dysfunction drugs 27342:Drug Industry Documents Archive 25482:N,alpha-Diethylphenylethylamine 23246:Monoamine metabolism modulators 17586:Meclofenoxate (centrophenoxine) 16911:Suxethonium (succinyldicholine) 16906:Suxamethonium (succinylcholine) 16516:Monoamine metabolism modulators 10950:European Medicines Agency (EMA) 10143:Weintraub D, Linder MW (2000). 9121:10.1016/j.neubiorev.2021.10.037 8697: 7966:10.1016/j.clinthera.2005.11.011 6944: 6796: 6040: 5789: 5607: 5068: 5038: 4666:from the original on 5 May 2022 4301: 3969:electronic Medicines Compendium 3922: 3404: 3195:compound, with an experimental 2956:modulation of the immune system 2227:Bupropion binding and activity 1906: 1726: 1582: 1170: 980:Key:SNPPWIUOZRMYNY-UHFFFAOYSA-N 27297:Canada v. GlaxoSmithKline Inc. 24164:Tooltip N,N-Dipropyltryptamine 23872:Tooltip N,N-Dipropyltryptamine 23572:Pentoxyverine (carbetapentane) 11098:Global News 18 September 2013. 10786:(1): 1–4. 2009. Archived from 8387:Journal of Medicinal Chemistry 7716:(164): 229–233. October 2015. 7490:Journal of Affective Disorders 7148:10.1002/14651858.CD001703.pub3 6196:10.1002/14651858.CD010078.pub3 6065:10.1002/14651858.CD003999.pub6 5868:10.1002/14651858.CD000031.pub6 5534:10.1002/14651858.CD011268.pub3 5188:Journal of Affective Disorders 4762:10.1002/14651858.CD009504.pub2 4527:10.1176/appi.ajp.2016.16050523 4444:10.1176/appi.ajp.2013.13050709 3930:"Bupropion hydrochloride EPAR" 3750: 3718: 3684: 3658: 3420: 3289:3'-chloro-2-bromopropiophenone 3109:and the more general class of 2927:nM. In contrast to many other 2777:. Bupropion does not act as a 1701:US National Poison Data System 1651: 1361: 1304:American Academy of Pediatrics 902: 884: 377: 364: 13: 1: 24513:Receptor/signaling modulators 23409:Dehydroepiandrosterone (DHEA) 23233:Monoamine reuptake inhibitors 23197:Receptor/signaling modulators 17622:Receptor/signaling modulators 17276:Hexamethonium (benzohexonium) 16496:Receptor/signaling modulators 15570:Tooltip Serotonin transporter 14194:Monoamine reuptake inhibitors 11264:Australian Medicines Handbook 11188:Journal of Addiction Medicine 11153:Journal of Addiction Medicine 11110:Journal of Addictions Nursing 11023:10.1080/00952990.2018.1545023 10567:Stenson J (12 October 2007). 10284:Journal of Chemical Education 10239:Journal of Medical Toxicology 9996:10.1080/00952990.2018.1545023 9923:10.1080/03602532.2019.1620763 9209:10.1080/14728222.2020.1805435 8863:10.1016/s0014-2999(97)01393-9 8492:10.1016/S0014-2999(03)02010-7 8224:10.1016/s0149-2918(08)80047-1 7898:Journal of Medical Toxicology 7400:10.1080/14728214.2021.1898588 7262:10.1080/14656566.2024.2319224 6353:10.1016/S2215-0366(18)30269-4 5277:10.1016/S0140-6736(17)32802-7 5143:10.1016/S0140-6736(09)60046-5 5006:"Wellbutrin approval package" 4866:10.1080/10550887.2022.2028531 4798:DeBattista C (16 June 2022). 4641:10.1080/15622975.2021.1878427 3553:10.1080/03602532.2019.1620763 3452: 2771:negative allosteric modulator 2354:Tooltip Serotonin transporter 1711:) that result in the highest 1464:Bupropion is available as an 1386: 1183: 1122:nicotinic receptor antagonist 373:(Other controlled substances) 66:1 : 1 mixture (racemate) 15410:Tetracyclic antidepressants: 14207:Tooltip Dopamine transporter 12127:Monoamine oxidase inhibitors 11356:10.1517/14656566.2011.534983 11200:10.1097/ADM.0000000000000249 11165:10.1097/ADM.0b013e3182824863 11122:10.3109/10884602.2011.647838 10821:Food and Drug Administration 10747:Food and Drug Administration 10715:Food and Drug Administration 10642:Food and Drug Administration 10606:Food and Drug Administration 10485:Food and Drug Administration 10448:Food and Drug Administration 10414:Food and Drug Administration 9726:10.1016/j.intimp.2005.12.007 8985:10.1097/FTD.0000000000001142 8793:10.1016/0014-2999(86)90596-0 7793:Food and Drug Administration 7447:10.1097/JCP.0000000000000329 7057:10.1097/MIB.0000000000000734 6930:10.1016/j.ejphar.2016.03.040 6810:Food and Drug Administration 6680:10.1016/j.mayocp.2016.09.018 6485:10.1097/JCP.0b013e3181a5233f 6303:10.1371/journal.pone.0240584 5443:10.1371/journal.pmed.1003886 5340:10.1371/journal.pone.0229381 5015:Food and Drug Administration 3347:In 1996, the FDA approved a 3337:Food and Drug Administration 3235: 3217:of bupropion exist, such as 3092: 3048:in the intestine leading to 2867:dopamine reuptake inhibition 2851:positron emission tomography 2252:Tooltip Dopamine transporter 1899:(MAOI), as it may result in 1565:monoamine oxidase inhibitors 1531:mg tablets) for depression. 1381:Food and Drug Administration 1379:has been approved by the US 1280:nicotine replacement therapy 7: 26546:Lysergic acid 2-butyl amide 23597:Racemethorphan (methorphan) 23066:Tetracyclic antidepressants 22641:Tetracyclic antidepressants 21904:Tetracyclic antidepressants 21480:Tetracyclic antidepressants 20729:Tetracyclic antidepressants 20134:Tetracyclic antidepressants 17356:Methorphan (racemethorphan) 16686:Bephenium hydroxynaphthoate 15860:3,3-Diphenylcyclobutanamine 15136:3,3-Diphenylcyclobutanamine 13967:conjugated equine estrogens 12848:Morphine (extended-release) 12321:Tooltip Monoamine oxidase B 12261:Tooltip Monoamine oxidase A 11890:tetracyclic antidepressants 9824:Psychopharmacology Bulletin 7044:Inflammatory Bowel Diseases 6768:Annals of Internal Medicine 5583:10.1097/MD.0000000000003165 4472:General Hospital Psychiatry 4370:. June 2006. Archived from 3758:"Zyban Product information" 3440: 3428: 3331:of Burroughs Wellcome (now 3141:, that is a mixture of two 3111:substituted phenethylamines 2963:tumor necrosis factor alpha 1897:monoamine oxidase inhibitor 1694: 1223:seasonal affective disorder 1146:substituted phenethylamines 1140:and more generally that of 1025:. It is also popular as an 10: 27543: 27472:Drugs developed by GSK plc 26556:Lysergic acid diethylamide 16736:Dimethylphenylpiperazinium 16500:Monoamine releasing agents 16058:Tricyclic antidepressants: 15334:Tricyclic antidepressants: 14403:Benzatropine (benztropine) 12891:Tooltip Adrenergic agonist 12785:Tooltip Adrenergic agonist 12745:Tooltip Adrenergic agonist 12645:Tooltip Adrenergic agonist 11798:Dextromethorphan/bupropion 10981:The Pharmaceutical Journal 9545:10.1007/s00210-023-02462-0 9502:10.1007/s10787-021-00829-4 8159:Medicinal Research Reviews 8035:Currax Pharmaceuticals LLC 7595:10.1016/j.cjca.2013.09.014 7085:Acta Dermato-Venereologica 6966:10.1007/s40263-023-01032-5 6630:10.1016/j.esxm.2018.01.004 6563:Basson R, Gilks T (2018). 5626:(1): 55–61. Archived from 5117:. WHO/MHP/HPS/EML/2023.02. 4570:10.1007/s40264-020-01027-x 4199:10.1016/j.jagp.2016.05.010 3702:(published 4 April 2023). 3327:Bupropion was invented by 3310: 2871:norepinephrine transporter 1586: 1521:dextromethorphan/bupropion 1460:Dextromethorphan/bupropion 1453: 1398:inflammatory bowel disease 1310:, bupropion has a delayed 1151:Bupropion was invented by 1124:. However, its effects on 874:Chemical and physical data 29: 27367: 27334: 27288: 27238: 27167: 27160: 27034: 26913: 26821: 26814: 26807: 26799:Smith, Kline & French 26734: 26718: 26681: 26674: 26448: 26209: 26098: 26035: 25847: 25777: 25101: 24560: 24506: 24232: 23955: 23308: 23187: 23144: 23088:Tricyclic antidepressants 23006:Metitepine (methiothepin) 22856: 22753: 22741: 22694: 22655:Tricyclic antidepressants 22586:Metitepine (methiothepin) 22460: 22333: 22321: 22270:Metitepine (methiothepin) 22252: 22203: 22191: 22136: 22025: 22013: 21983: 21763: 21641: 21629: 21611: 21573: 21525:Tricyclic antidepressants 21400:Metitepine (methiothepin) 21206: 20812: 20800: 20775: 20644:Metitepine (methiothepin) 20513: 20295: 20283: 20254: 20164:Tricyclic antidepressants 19995:Metitepine (methiothepin) 19719: 19273: 19261: 19249: 19228:Metitepine (methiothepin) 19220: 19135: 19123: 19091: 19083:Metitepine (methiothepin) 19075: 19024: 19012: 18974: 18946:Metitepine (methiothepin) 18878: 18710: 18698: 18665: 18637:Metitepine (methiothepin) 18560: 18411: 18399: 18364: 18286:Metitepine (methiothepin) 18150: 17707: 17695: 17683: 17614: 17528: 16989: 16585: 16571: 16488: 16444: 16313: 16124: 16053: 15852: 15776: 15590: 15563: 15441: 15405: 15329: 15128: 15052: 14966: 14880: 14853: 14536: 14390: 14354: 14278: 14227: 14200: 14142: 14001: 13927: 13854: 13826: 13763: 13683: 13617: 13599: 13563: 13538: 13515: 13423: 13373: 13243: 13185: 13002: 12993: 12877:Benzodiazepine dependence 12875: 12769: 12659: 12604: 12521: 12456: 12445: 12362: 12349: 12311: 12251: 12137: 12133: 12120: 12096: 12058: 11900: 11896: 11879: 11780: 11752: 11719: 11686: 11653: 11620: 11572: 11514: 11510: 11492: 11054:Current Neuropharmacology 10917:European Medicines Agency 10883:European Medicines Agency 10251:10.1007/s13181-010-0131-5 10211:10.1093/clinchem/41.6.955 9961:10.3109/00498258709043939 9676:10.1016/j.pbb.2020.173073 9417:10.1016/j.nsa.2022.101014 9370:10.1017/S1092852923001396 9237:Drug Development Research 8816:Psychopharmacology (Berl) 7836:10.3238/arztebl.2019.0355 7677:10.1038/s41433-019-0603-z 7502:10.1016/j.jad.2018.04.047 5715:10.1017/S1092852921000365 5698:"Bupropion-myth-busting!" 5200:10.1016/j.jad.2018.04.040 5101:World Health Organization 4975:Mehta NB (25 June 1974). 4050:World Health Organization 3934:European Medicines Agency 3381:European Medicines Agency 3250:nucleophilic displacement 3153:-bupropion. Although the 3028:and, to a lesser degree, 2712: 2194: 2163: 2133: 2103: 2080: 2057: 2034: 2002: 1977: 1958: 1946: 1934: 1922: 1919: 1916: 1878:tricyclic antidepressants 1709:tricyclic antidepressants 1672:(about 40% increase) and 1019:major depressive disorder 988: 963: 943: 921: 908: 878: 873: 841: 821: 801: 773: 753: 733: 713: 693: 668: 636: 608: 603: 573: 522: 484: 463: 449: 439: 431: 341: 336: 311: 296: 281: 255: 225: 211: 193: 179:-butyl-β-ketoamphetamine; 157: 153:Wellbutrin, Zyban, others 147: 76: 71: 59: 50: 27422:3-Chlorophenyl compounds 26789:S. E. Massengill Company 26689:GlaxoSmithKline Pakistan 25446:(Dextromethamphetamine, 23474:Fabomotizole (afobazole) 23449:Dimethyltryptamine (DMT) 22576:Latrepirdine (dimebolin) 22265:Latrepirdine (dimebolin) 21590:ergometrine (ergonovine) 21390:Latrepirdine (dimebolin) 20787:ergometrine (ergonovine) 19500:ergometrine (ergonovine) 19103:ergometrine (ergonovine) 18681:ergometrine (ergonovine) 18386:ergometrine (ergonovine) 17596:Phosphatidylethanolamine 15784:Atomoxetine (tomoxetine) 15060:Atomoxetine (tomoxetine) 12504:Rubidium chloride (RbCl) 11344:Expert Opin Pharmacother 11292:agence-prd.ansm.sante.fr 11076:10.2174/1570159033360566 10677:Waknine Y (8 May 2008). 10372:Whitten L (April 2006). 10344:"Bupropion (Wellbutrin)" 9592:10.4306/pi.2015.12.1.142 9289:10.3389/fnins.2016.00148 9197:Expert Opin Ther Targets 7250:Expert Opin Pharmacother 6867:Kampman KM (June 2008). 6581:10.1177/1745506518762664 5969:10.1586/14737175.6.7.965 4937:. Springer. p. 85. 4147:10.1177/2045125316629071 3352:and XL are available in 1646:Stevens–Johnson syndrome 1639:congenital heart defects 1142:substituted amphetamines 1111:congenital heart defects 1017:primarily used to treat 459:Threohydrobupropion: 42% 30:Not to be confused with 27497:Pro-motivational agents 26784:Reliant Pharmaceuticals 26666: 26100:Phenylalkylpyrrolidines 26022:Methylenedioxycathinone 25699:3,4-MDA (tenamfetamine) 24438:Mepyramine (pyrilamine) 24119:3-Methoxydextrallorphan 23779:3-Methoxydextrallorphan 23602:Racemorphan (morphanol) 22864:Atypical antipsychotics 22473:Atypical antipsychotics 21791:Atypical antipsychotics 21224:Atypical antipsychotics 20526:Atypical antipsychotics 19779:Atypical antipsychotics 18158:Atypical antipsychotics 17764:Atypical antipsychotics 17376:Morphanol (racemorphan) 17316:Laudexium (laudolissin) 16726:Desformylflustrabromine 16162:mepyramine (pyrilamine) 12367:Atypical antipsychotics 11094:26 October 2020 at the 10644:(FDA). 3 October 2012. 9984:Am J Drug Alcohol Abuse 9664:Pharmacol Biochem Behav 9410:. Elsevier BV: 101014. 9335:10.1124/jpet.115.229765 8898:10.1023/a:1006986824213 8449:10.1023/a:1006986824213 8123:10.1124/jpet.114.222356 7787:Levenson M, Holland C. 7753:10.5114/pdia.2014.40930 7710:Prescrire International 7297:10.1136/jim-2020-001272 6667:Mayo Clinic Proceedings 6115:10.1001/jama.2020.23541 5918:10.1186/1471-2458-6-300 5393:10.1136/bmj-2021-067606 4015:10.1124/jpet.116.232876 3700:Diário Oficial da União 3541:Drug Metabolism Reviews 3447:List of antidepressants 3435:social anxiety disorder 3294:bupropion hydrochloride 3284:3'-chloro-propiophenone 2845:(DAT) by bupropion (300 1973:Exposure and half-life 1439:in various conditions. 1375:. The combination drug 1105:. Bupropion use during 1015:atypical antidepressant 161:Amfebutamone; 3-Chloro- 27507:Sigma receptor ligands 25024:β-Methylphenethylamine 25018:α-Methylphenethylamine 24493:Tiospirone (BMY-13859) 24433:Gevotroline (WY-47384) 24358:18-Methoxycoronaridine 24345:Allosteric modulators: 24104:Panamesine (EMD-57455) 24054:Siramesine (Lu 28-179) 23991:Ditolylguanidine (DTG) 23754:Allosteric modulators: 23717:Panamesine (EMD-57455) 23662:BMY-14802 (BMS-181100) 23454:Ditolylguanidine (DTG) 23434:Dextromethorphan (DXM) 23106:Typical antipsychotics 22677:Typical antipsychotics 21937:Typical antipsychotics 21819:Bemesetron (MDL-72222) 21539:Typical antipsychotics 20752:Typical antipsychotics 20174:Typical antipsychotics 18865:5-(nonyloxy)tryptamine 16436:Vanoxerine (GBR-12909) 16283:pethidine (meperidine) 15538:pethidine (meperidine) 14326:Pethidine (meperidine) 11379:J Clin Psychopharmacol 10780:Drug Safety Newsletter 10149:Depression and Anxiety 10031:10.1002/chir.530050704 8934:10.1124/mol.104.001313 8578:10.1124/mol.119.118349 8566:Molecular Pharmacology 8531:10.1124/mol.104.001313 8519:Molecular Pharmacology 7006:10.1186/1745-0179-2-24 6341:The Lancet. Psychiatry 6245:10.1542/peds.2019-2528 6156:10.1001/jama.2020.3332 3324: 3191:g/mol. It is a highly 3107:substituted cathinones 2978: 2935:, bupropion is not an 2923:values of 580 to 2,100 1751:(active metabolite of 1721:abnormal heart rhythms 1180: 1138:substituted cathinones 561:Erythrohydrobupropion: 27487:Nicotinic antagonists 27347:GlaxoSmithKline Prize 26774:Human Genome Sciences 26215:(and close relatives) 25714:MDMA (midomafetamine) 25056:-Methylphenethylamine 25048:-Methylphenethylamine 25040:-Methylphenethylamine 25032:-Methylphenethylamine 23764:Methylphenylpiracetam 23339:Alazocine (SKF-10047) 23255:Monoamine neurotoxins 21033:MDMA (midomafetamine) 20417:MDMA (midomafetamine) 20020:Opiranserin (VVZ-149) 19574:MDMA (midomafetamine) 19280:25H/NB series (e.g., 17581:Glycerophosphocholine 16520:Monoamine neurotoxins 16086:Dosulepin (dothiepin) 15633:Didesmethylcitalopram 15362:Dosulepin (dothiepin) 15039:Serdexmethylphenidate 14341:Serdexmethylphenidate 13828:Melanocortin agonists 13564:Absorption inhibitors 11262:Rossi S, ed. (2013). 10952:. 26 September 2019. 10476:"FDA approval letter" 9249:10.1002/ddr.430240107 9159:Fundam Clin Pharmacol 9109:Neurosci Biobehav Rev 8212:Clinical Therapeutics 7954:Clinical Therapeutics 7795:(FDA). Archived from 7215:J Head Trauma Rehabil 7098:10.2340/00015555-2702 6398:10.1089/cap.2016.0124 5046:"The Top 300 of 2022" 4322:10.1055/s-0043-117962 3936:. 17 September 2018. 3318: 2998:first-pass metabolism 2976: 1868:Bupropion lowers the 1621:liver transplantation 1429:motivational deficits 1178: 511:Erythrohydrobupropion 457:Hydroxybupropion: 77% 27522:Tert-butyl compounds 26744:Allen & Hanburys 26699:Stiefel Laboratories 26379:N,N-Dimethyldopamine 26037:Phenylisobutylamines 25734:Naphthylaminopropane 25419:Isopropylamphetamine 25409:4-Hydroxyamphetamine 23587:Pregnenolone sulfate 23399:Cutamesine (SA-4503) 21727:bufotenidine (5-HTQ) 20850:5-Methoxytryptamines 19364:5-Methoxytryptamines 17576:Dimethylethanolamine 17441:Rapacuronium bromide 17421:Pipecuronium bromide 17261:Gantacurium chloride 17221:Dizocilpine (MK-801) 16806:MEM-63,908 (RG-3487) 16756:Ethoxysebacylcholine 16411:Methoxytetrabenazine 16376:Dihydrotetrabenazine 16190:Arylcyclohexylamines 15485:Arylcyclohexylamines 14636:Dizocilpine (MK-801) 14590:Chaenomeles speciosa 14291:Benocyclidine (BTCP) 12488:Hypericum perforatum 12356:Adjunctive therapies 10719:. 24 December 1999. 9490:Inflammopharmacology 9404:Neuroscience Applied 9323:J Pharmacol Exp Ther 8754:J Pharmacol Exp Ther 8259:10.4088/jcp.v65n1113 7799:on 27 September 2007 6575:: 1745506518762664. 6532:10.4088/PCC.v06n0403 5667:10.4088/JCP.v69n0812 5494:10.1056/NEJMsa065779 5271:(10128): 1357–1366. 5019:. 30 December 1985. 4406:10.4088/jcp.v66n0215 4054:WHO Drug Information 3605:10.4088/pcc.v07n0305 3101:that belongs to the 2843:dopamine transporter 1816:area-under-the-curve 1619:leading to death or 1509:naltrexone/bupropion 1456:Naltrexone/bupropion 1377:naltrexone/bupropion 1132:that belongs to the 1116:Bupropion acts as a 1013:among others, is an 551:Threohydrobupropion: 292:(swallowed by mouth) 26541:Lysergic acid amide 26287:Ethylnorepinephrine 26090:Phenylisobutylamine 25542:Phenylpropanolamine 25477:-Norpseudoephedrine 25448:Levomethamphetamine 25335:Dimethylamphetamine 23737:Rimcazole (BW-234U) 22345:dihydroergocryptine 21029:MDA (tenamfetamine) 20413:MDA (tenamfetamine) 20378:dihydroergocryptine 19570:MDA (tenamfetamine) 17591:Phosphatidylcholine 17476:Threohydrobupropion 17461:Stercuronium iodide 17396:Pancuronium bromide 16035:Threohydrobupropion 15900:Desmethylsertraline 15628:Desmethylcitalopram 15311:Threohydrobupropion 15176:Desmethylsertraline 14831:Threohydrobupropion 14606:Desmethylsertraline 13336:Phenylpropanolamine 13215:Levopropylhexedrine 13187:Adrenergic agonists 13017:4-Methylamphetamine 12702:General anesthetics 12606:Nicotine dependence 11504:receptor modulators 11500:reuptake inhibitors 10827:on 20 December 2016 10793:on 11 February 2017 10489:. 6 December 2006. 10384:(5). Archived from 10324:on 25 February 2011 10296:2000JChEd..77.1479P 10204:(6 Pt 1): 955–956. 9714:Int Immunopharmacol 9580:Psychiatry Investig 8666:"Bupropion – PDSP K 7537:Clinical Cardiology 6708:Curr Neuropharmacol 6294:2020PLoSO..1540584E 5614:Clayton AH (2003). 5331:2020PLoSO..1529381H 4081:Sweetman S (2011). 3843:. 5 November 2019. 3391:Society and culture 2763:mechanism of action 2228: 1913: 1901:hypertensive crisis 1797:lopinavir/ritonavir 1641:in their children. 1632:open angle glaucoma 1198:quality of evidence 503:Threohydrobupropion 397:(Prescription only) 360:(Prescription only) 47: 27442:Anti-obesity drugs 27251:Silas M. Burroughs 26794:SmithKline Beecham 26759:Burroughs Wellcome 24997:Phenylethanolamine 23494:Igmesine (JO-1784) 23423:prasterone sulfate 23170:naphthylpiperazine 22941:2-Br-LSD (BOL-148) 22728:naphthylpiperazine 22706:2-Br-LSD (BOL-148) 22308:naphthylpiperazine 22215:2-Br-LSD (BOL-148) 22000:naphthylpiperazine 20876:α-Alkyltryptamines 19390:α-Alkyltryptamines 17674:Serotonin receptor 17511:Vecuronium bromide 17451:Rocuronium bromide 17361:Methyllycaconitine 17286:Hydroxynorketamine 17181:Dextropropoxyphene 17166:Dehydronorketamine 17156:Dacuronium bromide 16275:dextropropoxyphene 14301:Dexmethylphenidate 13945:methyltestosterone 13754:Sexual dysfunction 13710:Never to phase III 13635:Desiccated thyroid 13281:Dexmethylphenidate 12978:Antiobesity agents 12856:Opioid antagonists 12716:Opioid antagonists 12694:Hydrogen cyanamide 12661:Alcohol dependence 12548:Never to phase III 10852:The New York Times 10753:on 19 October 2010 10581:on 11 October 2013 10548:on 20 October 2012 10304:10.1021/ed077p1479 10198:Clinical Chemistry 8886:Cell Mol Neurobiol 8828:10.1007/BF02244985 7910:10.1007/BF03161207 7196:10.17863/CAM.40216 6885:10.1151/ascp084228 6440:10.1586/ern.11.137 5815:10.2147/copd.s1121 5764:10.3390/ph13060116 5620:Primary Psychiatry 4310:Pharmacopsychiatry 3325: 2979: 2362:47,000–>100,000 2226: 1911: 1561:alcohol withdrawal 1425:effort expenditure 1336:sexual dysfunction 1330:Sexual dysfunction 1192:of bupropion over 1181: 1157:Burroughs Wellcome 1083:excessive sweating 1005:, formerly called 43: 27512:Smoking cessation 27462:CYP2D6 inhibitors 27427:5-HT3 antagonists 27387: 27386: 27284: 27283: 27156: 27155: 27030: 27029: 26730: 26729: 26634: 26633: 25975:N-Ethylpentedrone 25935:Dimethylcathinone 25557:Propylamphetamine 25300:Dextroamphetamine 24972:Methallylescaline 24520: 24519: 24355:Unknown/unsorted: 24116:Unknown/unsorted: 23851: 23776:Unknown/unsorted: 23439:Dextrorphan (DXO) 23265: 23264: 23258: 23249: 23240: 23227: 23218: 23209: 23200: 23183: 23182: 23179: 23178: 23149:Unknown/unsorted: 22957:dihydroergotamine 22737: 22736: 22699:Unknown/unsorted: 22349:dihydroergotamine 22317: 22316: 22287:Unknown/unsorted: 22187: 22186: 22009: 22008: 21988:Unknown/unsorted: 21657:ethanol (alcohol) 21607: 21606: 21603: 21602: 21578:Unknown/unsorted: 20969:dihydroergotamine 20796: 20795: 20780:Unknown/unsorted: 20382:dihydroergotamine 20279: 20278: 20266:dihydroergotamine 20259:Unknown/unsorted: 20088:hydroxynefazodone 19245: 19244: 19241: 19240: 19119: 19118: 19096:Unknown/unsorted: 19008: 19007: 18979:Unknown/unsorted: 18745:dihydroergotamine 18694: 18693: 18670:Unknown/unsorted: 18462:dihydroergotamine 18395: 18394: 18369:Unknown/unsorted: 18197:iodocyanopindolol 17885:dihydroergotamine 17738:hydroxynefazodone 17640: 17639: 17601:Phosphorylcholine 17539: 17524: 17523: 17321:Levacetylmethadol 17201:Dihydrochandonium 17081:sodium thiopental 16751:Ethanol (alcohol) 16528: 16527: 16523: 16309: 16308: 15584: 15559: 15558: 15004:Levophacetoperane 14874: 14849: 14848: 14711:Levophacetoperane 14286:4-Fluoropethidine 14221: 14160: 14159: 13949:anabolic steroids 13894:Nitrosoprodenafil 13765:Dopamine agonists 13757:pharmacotherapies 13720: 13719: 13609:2,4-Dinitrophenol 13542:receptor agonists 13437:glucagon agonists 13369: 13368: 13087:Dimethylcathinone 13082:Dextroamphetamine 12944: 12943: 12823:Levacetylmethadol 12771:Opioid dependence 12689:Calcium carbimide 12558: 12557: 12517: 12516: 12490:(St. John's Wort) 12441: 12440: 12406:lithium carbonate 12345: 12344: 12341: 12340: 12116: 12115: 12112: 12111: 11925:Amitriptylinoxide 11875: 11874: 11871: 11870: 11328:978-0-85711-156-2 11273:978-0-9805790-9-3 10452:. 8 August 2003. 10418:. 22 April 2005. 10122:978-3-88763-101-7 9884:978-0-12-420118-7 9772:978-0-07-162442-8 9203:(10): 1009–1028. 9057:Neuropharmacology 8615:Neuropharmacology 8399:10.1021/jm1003232 8393:(12): 4731–4748. 8253:(11): 1520–1524. 8171:10.1002/med.21671 7960:(11): 1685–1695. 7878:978-0-470-97969-3 7589:(12): 1704–1711. 7549:10.1002/clc.22744 6844:. 26 April 2019. 6714:(10): 1941–1955. 6434:(10): 1443–1465. 6149:(16): 1599–1608. 6016:10.1111/add.14134 5905:BMC Public Health 5796:Wilkes S (2008). 5137:(9665): 746–758. 4944:978-3-319-56449-4 4813:978-1-61537-331-4 4711:978-0-12-420118-7 4289:(Suppl 6): 9–15. 4092:978-0-85369-982-8 3796:. 21 April 2022. 3766:. 25 April 2012. 3734:. 25 April 2012. 3694:(31 March 2023). 3349:sustained-release 3308: 3307: 3261:hydrochloric acid 3259:and treated with 3173:molecular formula 3040:in the liver and 3026:-hydroxybupropion 2954:activity through 2948:anti-inflammatory 2841:The occupancy of 2808:-hydroxybupropion 2759: 2758: 2732:, β-adrenergic, D 2720:) were >10,000 2437:>10,000–81,000 2358:9,100–>100,000 2219: 2218: 1577:suicidal ideation 1545:seizure threshold 1535:Contraindications 1352:systematic review 1266:for nicotine and 1258:Smoking cessation 1023:smoking cessation 1000: 999: 934:Interactive image 843:CompTox Dashboard 541:Hydroxybupropion: 420: 405: 392: 380: 368: 355: 271: 238: 16:(Redirected from 27534: 27404: 27403: 27402: 27395: 27375: 27374: 27202:Patrick Vallance 27165: 27164: 26894:Wellbutrin/Zyban 26819: 26818: 26812: 26811: 26679: 26678: 26661: 26654: 26647: 26638: 26637: 26340: 26332: 26323: 26314: 26255: 26216: 25970:N-Ethylhexedrone 25950:Hydroxybupropion 25790:Chlorphentermine 25767: 25476: 25454:Methoxyphenamine 25429:Lisdexamfetamine 25373:Levofenfluramine 25013:Phenpromethamine 24547: 24540: 24533: 24524: 24523: 24210: 24206: 24165: 24161: 24155: 24151: 24024:(midomafetamine) 24023: 23873: 23869: 23863: 23859: 23849: 23517:(midomafetamine) 23516: 23385: 23381: 23292: 23285: 23278: 23269: 23268: 23252: 23243: 23237:releasing agents 23230: 23221: 23212: 23203: 23191: 22816:Serotonin (5-HT) 22751: 22750: 22384:Serotonin (5-HT) 22331: 22330: 22229:Serotonin (5-HT) 22201: 22200: 22108:Serotonin (5-HT) 22023: 22022: 21859:Hydroxybupropion 21700:Serotonin (5-HT) 21661:trichloroethanol 21639: 21638: 21627: 21626: 21132:Serotonin (5-HT) 20810: 20809: 20451:Serotonin (5-HT) 20333:levofenfluramine 20317:chlorphentermine 20303:4-Methylaminorex 20293: 20292: 20206:prochlorperazine 20030:Phenoxybenzamine 20000:MIN-117 (WF-516) 19655:Serotonin (5-HT) 19271: 19270: 19259: 19258: 19184:Serotonin (5-HT) 19133: 19132: 19047:Serotonin (5-HT) 19022: 19021: 18793:Serotonin (5-HT) 18708: 18707: 18494:Serotonin (5-HT) 18409: 18408: 18291:MIN-117 (WF-516) 18060:Serotonin (5-HT) 17705: 17704: 17693: 17692: 17667: 17660: 17653: 17644: 17643: 17533: 17471:Thiocolchicoside 17281:Hydroxybupropion 17176:Dextromethorphan 17048:Allopregnanolone 17002: 16998: 16901:Suberyldicholine 16611:6-Chloronicotine 16598: 16594: 16583: 16582: 16579: 16575: 16555: 16548: 16541: 16532: 16531: 16490: 16477:Antagonist-like: 16371:Deutetrabenazine 16321: 16317: 16261:MIN-117 (WF-516) 16226:Dextromethorphan 15598:6-Nitroquipazine 15588: 15587: 15582: 15578: 15573: 15571: 15567: 14994:Hydroxybupropion 14878: 14877: 14872: 14868: 14863: 14861: 14857: 14751:MIN-117 (WF-516) 14691:Hydroxybupropion 14631:Diphenylpyraline 14362:Diphenylprolinol 14225: 14224: 14219: 14215: 14210: 14208: 14204: 14187: 14180: 14173: 14164: 14163: 14092:Psychostimulants 13963:ethinylestradiol 13747: 13740: 13733: 13724: 13723: 13137:Lisdexamfetamine 13062:Chlorphentermine 13000: 12999: 12971: 12964: 12957: 12948: 12947: 12918:Chlordiazepoxide 12892: 12888: 12838:Dihydroetorphine 12786: 12782: 12746: 12742: 12672: 12646: 12642: 12585: 12578: 12571: 12562: 12561: 12498: 12464: 12447: 12446: 12420:triiodothyronine 12416:Thyroid hormones 12351: 12350: 12322: 12318: 12262: 12258: 12203:Phenoxypropazine 12135: 12134: 12122: 12121: 12066: 12062: 11908: 11904: 11898: 11897: 11881: 11880: 11760: 11756: 11727: 11723: 11694: 11690: 11661: 11657: 11628: 11624: 11580: 11576: 11522: 11518: 11512: 11511: 11494: 11493: 11474: 11467: 11460: 11451: 11450: 11444: 11443: 11433: 11409: 11403: 11402: 11374: 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Archived from 10597: 10591: 10590: 10588: 10586: 10577:. Archived from 10564: 10558: 10557: 10555: 10553: 10538: 10532: 10531: 10529: 10527: 10512: 10506: 10505: 10503: 10501: 10495: 10480: 10472: 10466: 10465: 10463: 10461: 10438: 10432: 10431: 10429: 10427: 10404: 10398: 10397: 10395: 10393: 10388:on 5 August 2007 10369: 10360: 10359: 10357: 10355: 10340: 10334: 10333: 10331: 10329: 10314: 10308: 10307: 10279: 10273: 10272: 10262: 10230: 10224: 10223: 10213: 10189: 10183: 10182: 10164: 10140: 10134: 10133: 10131: 10129: 10106: 10100: 10099: 10097: 10095: 10080: 10071: 10070: 10068: 10066: 10052: 10043: 10042: 10014: 10008: 10007: 9979: 9973: 9972: 9944: 9935: 9934: 9906: 9897: 9896: 9862: 9849: 9846: 9840: 9839: 9819: 9813: 9812: 9789:Pharmacogenetics 9783: 9777: 9776: 9756: 9750: 9749: 9747: 9745: 9705: 9696: 9695: 9659: 9650: 9649: 9620: 9614: 9613: 9603: 9571: 9565: 9564: 9539:(9): 2087–2093. 9528: 9522: 9521: 9496:(4): 1101–1109. 9485: 9479: 9478: 9468: 9444: 9438: 9437: 9419: 9395: 9386: 9385: 9353: 9347: 9346: 9318: 9312: 9311: 9301: 9291: 9267: 9261: 9260: 9231: 9225: 9224: 9192: 9183: 9182: 9154: 9143: 9142: 9132: 9100: 9089: 9088: 9052: 9046: 9045: 9035: 9003: 8997: 8996: 8968: 8955: 8952: 8946: 8945: 8916: 8910: 8909: 8881: 8875: 8874: 8857:(2–3): 249–258. 8846: 8840: 8839: 8811: 8805: 8804: 8787:(2–3): 115–121. 8776: 8770: 8769: 8749: 8743: 8742: 8740: 8738: 8724: 8715: 8714: 8712: 8710: 8695: 8686: 8685: 8683: 8681: 8658: 8649: 8648: 8638: 8606: 8600: 8599: 8589: 8557: 8551: 8550: 8513: 8504: 8503: 8475: 8469: 8468: 8432: 8421: 8420: 8410: 8378: 8363: 8362: 8343:10.1002/cpt.1888 8337:(5): 1036–1048. 8326: 8320: 8319: 8309: 8298:10.1002/cpt.1309 8292:(5): 1164–1174. 8277: 8271: 8270: 8242: 8236: 8235: 8218:(7): 1206–1227. 8207: 8201: 8200: 8182: 8165:(5): 1794–1832. 8153: 8144: 8143: 8125: 8101: 8095: 8094: 8084: 8060: 8054: 8053: 8051: 8049: 8043: 8032: 8024: 8013: 8012: 7984: 7978: 7977: 7949: 7932: 7931: 7921: 7889: 7883: 7882: 7864: 7858: 7857: 7847: 7815: 7809: 7808: 7806: 7804: 7784: 7775: 7774: 7764: 7732: 7726: 7725: 7705: 7699: 7698: 7688: 7656: 7650: 7649: 7613: 7607: 7606: 7577: 7571: 7570: 7560: 7528: 7522: 7521: 7485: 7479: 7478: 7476: 7474: 7426: 7420: 7419: 7382: 7376: 7375: 7373: 7371: 7352: 7346: 7345: 7343: 7341: 7326: 7309: 7308: 7291:(6): 1156–1158. 7280: 7274: 7273: 7245: 7239: 7238: 7210: 7204: 7203: 7181: 7170: 7169: 7159: 7127: 7121: 7120: 7110: 7100: 7076: 7070: 7069: 7059: 7050:(6): 1509–1522. 7035: 7029: 7028: 7018: 7008: 6984: 6978: 6977: 6948: 6942: 6941: 6913: 6907: 6906: 6896: 6864: 6858: 6857: 6855: 6853: 6834: 6828: 6827: 6825: 6823: 6800: 6794: 6793: 6783: 6759: 6750: 6749: 6731: 6699: 6693: 6692: 6682: 6658: 6652: 6651: 6641: 6609: 6603: 6602: 6592: 6560: 6554: 6553: 6543: 6511: 6505: 6504: 6468: 6462: 6461: 6451: 6419: 6410: 6409: 6381: 6375: 6374: 6364: 6332: 6326: 6325: 6315: 6305: 6288:(10): e0240584. 6273: 6267: 6266: 6256: 6239:(4): e20192528. 6224: 6218: 6217: 6207: 6175: 6169: 6168: 6158: 6134: 6128: 6127: 6117: 6093: 6087: 6086: 6076: 6044: 6038: 6037: 6027: 5995: 5989: 5988: 5952: 5941: 5940: 5930: 5920: 5896: 5890: 5889: 5879: 5847: 5838: 5837: 5827: 5817: 5793: 5787: 5786: 5776: 5766: 5742: 5736: 5735: 5717: 5693: 5687: 5686: 5661:(8): 1287–1292. 5649: 5640: 5639: 5637: 5635: 5611: 5605: 5604: 5594: 5562: 5556: 5555: 5545: 5513: 5507: 5506: 5496: 5472: 5466: 5465: 5455: 5445: 5421: 5415: 5414: 5404: 5372: 5363: 5362: 5352: 5342: 5310: 5299: 5298: 5288: 5256: 5245: 5244: 5242: 5240: 5234: 5211: 5185: 5176: 5163: 5162: 5125: 5119: 5118: 5116: 5097: 5091: 5090: 5088: 5086: 5072: 5066: 5065: 5063: 5061: 5042: 5036: 5035: 5033: 5031: 5025: 5010: 5002: 4993: 4992: 4990: 4988: 4972: 4961: 4960: 4958: 4956: 4928: 4919: 4918: 4916: 4914: 4895: 4886: 4885: 4849: 4838: 4837: 4835: 4833: 4795: 4784: 4783: 4773: 4756:(10): CD009504. 4741: 4724: 4723: 4689: 4676: 4675: 4673: 4671: 4665: 4626: 4617: 4602: 4601: 4599: 4597: 4549: 4540: 4539: 4529: 4505: 4496: 4495: 4467: 4456: 4455: 4427: 4418: 4417: 4388: 4379: 4378: 4377:on 17 July 2011. 4376: 4365: 4357: 4342: 4341: 4305: 4299: 4298: 4278: 4269: 4268: 4232: 4221: 4220: 4210: 4178: 4169: 4168: 4158: 4126: 4097: 4096: 4078: 4072: 4071: 4069: 4046: 4037: 4036: 4026: 3994: 3985: 3984: 3982: 3980: 3961: 3950: 3949: 3947: 3945: 3926: 3920: 3919: 3917: 3915: 3896: 3887: 3886: 3884: 3882: 3873:. 4 March 2022. 3863: 3857: 3856: 3854: 3852: 3833: 3810: 3809: 3807: 3805: 3786: 3780: 3779: 3777: 3775: 3754: 3748: 3747: 3745: 3743: 3722: 3716: 3715: 3713: 3711: 3688: 3682: 3681: 3679: 3677: 3662: 3656: 3655: 3653: 3651: 3641:nctr-crs.fda.gov 3633: 3627: 3626: 3616: 3584: 3573: 3572: 3536: 3487: 3486: 3484: 3482: 3463: 3396:Recreational use 3295: 3290: 3285: 3278: 3267: 3229:, among others. 3219:hydroxybupropion 3190: 3185:molecular weight 3097:Bupropion is an 3071:hydroxybupropion 3036:pathways are by 3007:pathways are by 2969:Pharmacokinetics 2952:pro-inflammatory 2926: 2922: 2918: 2860: 2848: 2783:hydroxybupropion 2747: 2743: 2723: 2696: 2692: 2671: 2649: 2623: 2593: 2563: 2533: 2503: 2459:6,600–>10,000 2433: 2407: 2360:1,000–>10,000 2355: 2351: 2304: 2300: 2253: 2249: 2229: 2225: 2222:Pharmacodynamics 1914: 1910: 1828:dextromethorphan 1733:hydroxybupropion 1662:suicidal thought 1549:anorexia nervosa 1530: 1526: 1518: 1514: 1502: 1498: 1493: 1489: 1485: 1282:but inferior to 1227:bipolar disorder 1162: 1155:, who worked at 996: 995: 936: 916: 904: 901: 898: 892: 886: 866: 865: 851: 849: 834: 814: 794: 786: 766: 746: 726: 706: 686: 676: 675: 649: 593: 589: 585: 568: 564: 558: 554: 548: 544: 538: 534: 527: 517: 509: 501: 495:Hydroxybupropion 493: 418: 415: 410: 403: 400: 390: 387: 379: 376: 366: 363: 353: 350: 328: 269: 266: 248: 237: 234: 221: 207: 139: 129: 122: 121: 118: 117: 114: 111: 108: 105: 102: 99: 96: 93: 90: 87: 64: 55: 48: 46: 42: 21: 27542: 27541: 27537: 27536: 27535: 27533: 27532: 27531: 27437:Antidepressants 27412: 27411: 27410: 27400: 27398: 27390: 27388: 27383: 27363: 27330: 27280: 27234: 27230:Laurie Glimcher 27197:Manvinder Banga 27192:Roy M. Anderson 27187:Simon Dingemans 27169: 27152: 27026: 26909: 26803: 26736: 26726: 26714: 26709:ViiV Healthcare 26670: 26665: 26635: 26630: 26566:Methoxphenidine 26444: 26409:Normetanephrine 26338: 26330: 26321: 26312: 26253: 26214: 26213: 26205: 26094: 26085: 26031: 25992: 25843: 25834: 25822: 25773: 25765: 25741: 25589: 25577:Tranylcypromine 25562:Pseudoephedrine 25474: 25469:Norfenfluramine 25444:Methamphetamine 25369:Dexfenfluramine 25304:Levoamphetamine 25251: 25149:Bromo-DragonFLY 25097: 25083: 25061:Methylphenidate 24992: 24562:Phenethylamines 24556: 24554:Phenethylamines 24551: 24521: 24516: 24502: 24422:St. John's wort 24248:Ethylketazocine 24228: 24208: 24163: 24153: 24029:Methamphetamine 23960: 23951: 23937:Trifluoperazine 23871: 23861: 23537:Methylphenidate 23527:Methamphetamine 23383: 23313: 23304: 23296: 23266: 23261: 23175: 23140: 23118:chlorprothixene 22852: 22746: 22733: 22690: 22456: 22326: 22313: 22248: 22196: 22183: 22132: 22018: 22005: 21979: 21947:Volatiles/gases 21759: 21749:trichloroethane 21733:Volatiles/gases 21672:Phenylbiguanide 21634: 21623: 21616: 21599: 21569: 21202: 21072:Phenethylamines 20805: 20792: 20771: 20509: 20337:norfenfluramine 20325:dexfenfluramine 20288: 20275: 20250: 20230:trifluoperazine 19881:Chlorprothixene 19715: 19623:Phenethylamines 19434:Bromo-DragonFLY 19266: 19254: 19237: 19216: 19128: 19115: 19087: 19071: 19017: 19004: 18970: 18874: 18703: 18690: 18661: 18556: 18404: 18391: 18360: 18146: 17730:Antidepressants 17700: 17688: 17679: 17671: 17641: 17636: 17610: 17532: 17520: 17126:Chlorisondamine 17000: 16993: 16985: 16596: 16589: 16577: 16567: 16559: 16529: 16524: 16484: 16462:DAT modulators: 16440: 16341:methamphetamine 16319: 16305: 16216:Cyclobenzaprine 16158:diphenhydramine 16146:brompheniramine 16120: 16049: 15848: 15814:Levomilnacipran 15772: 15580: 15572: 15569: 15555: 15453:brompheniramine 15437: 15401: 15325: 15124: 15085:Levomilnacipran 15048: 15019:Methylphenidate 14962: 14870: 14862: 14859: 14845: 14532: 14386: 14350: 14321:Methylphenidate 14296:Desoxypipradrol 14274: 14217: 14209: 14206: 14196: 14191: 14161: 14156: 14138: 14104:methylphenidate 13997: 13923: 13904:Sulfoaildenafil 13856:PDE5 inhibitors 13850: 13822: 13759: 13751: 13721: 13716: 13715: 13700:Clinical trials 13679: 13613: 13595: 13559: 13541: 13534: 13511: 13435: 13419: 13376: 13365: 13346:Propylhexedrine 13321:Phendimetrazine 13316:Methylphenidate 13276:Dexfenfluramine 13239: 13181: 13152:Norfenfluramine 13147:Methamphetamine 13009:phenethylamines 13007: 12989: 12975: 12945: 12940: 12903:Benzodiazepines 12890: 12871: 12784: 12765: 12744: 12655: 12644: 12600: 12593:drug dependence 12589: 12559: 12554: 12553: 12538:Clinical trials 12513: 12452: 12437: 12433: 12425: 12410:lithium citrate 12358: 12337: 12320: 12317: 12307: 12260: 12257: 12247: 12223:Tranylcypromine 12129: 12108: 12092: 12064: 12054: 11906: 11892: 11867: 11776: 11758: 11748: 11725: 11715: 11692: 11682: 11659: 11649: 11626: 11616: 11597:Levomilnacipran 11578: 11568: 11520: 11506: 11488: 11481:Antidepressants 11478: 11448: 11447: 11418:Depress Anxiety 11410: 11406: 11375: 11371: 11340: 11336: 11329: 11315: 11311: 11301: 11299: 11286: 11285: 11281: 11274: 11260: 11256: 11243: 11241: 11228: 11227: 11223: 11184: 11180: 11149: 11145: 11106: 11102: 11096:Wayback Machine 11087: 11083: 11067:10.1.1.325.9635 11050: 11046: 11007: 11000: 10990: 10988: 10973: 10969: 10959: 10957: 10944: 10943: 10939: 10929: 10927: 10923: 10912: 10906: 10902: 10892: 10890: 10875: 10871: 10861: 10859: 10844: 10840: 10830: 10828: 10811: 10810: 10806: 10796: 10794: 10790: 10775: 10771: 10770: 10766: 10756: 10754: 10741: 10740: 10736: 10726: 10724: 10707: 10706: 10702: 10692: 10690: 10675: 10671: 10659: 10651: 10649: 10636: 10635: 10626: 10616: 10614: 10599: 10598: 10594: 10584: 10582: 10565: 10561: 10551: 10549: 10540: 10539: 10535: 10525: 10523: 10522:on 30 June 2007 10514: 10513: 10509: 10499: 10497: 10493: 10478: 10474: 10473: 10469: 10459: 10457: 10440: 10439: 10435: 10425: 10423: 10406: 10405: 10401: 10391: 10389: 10370: 10363: 10353: 10351: 10342: 10341: 10337: 10327: 10325: 10316: 10315: 10311: 10280: 10276: 10231: 10227: 10190: 10186: 10141: 10137: 10127: 10125: 10123: 10107: 10103: 10093: 10091: 10090:. 30 March 2009 10088:DrugBank Online 10082: 10081: 10074: 10064: 10062: 10054: 10053: 10046: 10015: 10011: 9980: 9976: 9945: 9938: 9907: 9900: 9885: 9863: 9852: 9847: 9843: 9820: 9816: 9784: 9780: 9773: 9757: 9753: 9743: 9741: 9706: 9699: 9660: 9653: 9626:Transplant Proc 9621: 9617: 9572: 9568: 9529: 9525: 9486: 9482: 9445: 9441: 9396: 9389: 9354: 9350: 9319: 9315: 9268: 9264: 9232: 9228: 9193: 9186: 9155: 9146: 9101: 9092: 9053: 9049: 9004: 9000: 8973:Ther Drug Monit 8969: 8958: 8953: 8949: 8917: 8913: 8882: 8878: 8851:Eur J Pharmacol 8847: 8843: 8812: 8808: 8781:Eur J Pharmacol 8777: 8773: 8750: 8746: 8736: 8734: 8726: 8725: 8718: 8708: 8706: 8696: 8689: 8679: 8677: 8669: 8659: 8652: 8621:(Pt A): 89–99. 8607: 8603: 8558: 8554: 8514: 8507: 8476: 8472: 8433: 8424: 8379: 8366: 8327: 8323: 8278: 8274: 8243: 8239: 8208: 8204: 8154: 8147: 8102: 8098: 8082:10.18433/J3H03R 8061: 8057: 8047: 8045: 8041: 8030: 8026: 8025: 8016: 7985: 7981: 7950: 7935: 7890: 7886: 7879: 7865: 7861: 7830:(20): 355–361. 7816: 7812: 7802: 7800: 7785: 7778: 7733: 7729: 7707: 7706: 7702: 7657: 7653: 7614: 7610: 7578: 7574: 7543:(10): 899–906. 7529: 7525: 7486: 7482: 7472: 7470: 7427: 7423: 7383: 7379: 7369: 7367: 7354: 7353: 7349: 7339: 7337: 7328: 7327: 7312: 7281: 7277: 7246: 7242: 7211: 7207: 7182: 7173: 7142:(1): CD001703. 7128: 7124: 7077: 7073: 7036: 7032: 6985: 6981: 6960:(10): 867–881. 6949: 6945: 6914: 6910: 6865: 6861: 6851: 6849: 6836: 6835: 6831: 6821: 6819: 6802: 6801: 6797: 6760: 6753: 6700: 6696: 6659: 6655: 6618:Sexual Medicine 6610: 6606: 6561: 6557: 6512: 6508: 6469: 6465: 6420: 6413: 6382: 6378: 6333: 6329: 6274: 6270: 6225: 6221: 6190:(3): CD010078. 6176: 6172: 6135: 6131: 6094: 6090: 6045: 6041: 5996: 5992: 5953: 5944: 5897: 5893: 5862:(5): CD000031. 5848: 5841: 5794: 5790: 5751:Pharmaceuticals 5743: 5739: 5694: 5690: 5650: 5643: 5633: 5631: 5612: 5608: 5563: 5559: 5528:(4): CD011268. 5514: 5510: 5473: 5469: 5436:(1): e1003886. 5422: 5418: 5373: 5366: 5325:(2): e0229381. 5311: 5302: 5257: 5248: 5238: 5236: 5232: 5183: 5177: 5166: 5126: 5122: 5098: 5094: 5084: 5082: 5074: 5073: 5069: 5059: 5057: 5044: 5043: 5039: 5029: 5027: 5023: 5008: 5004: 5003: 4996: 4986: 4984: 4973: 4964: 4954: 4952: 4945: 4929: 4922: 4912: 4910: 4897: 4896: 4889: 4850: 4841: 4831: 4829: 4814: 4796: 4787: 4742: 4727: 4712: 4690: 4679: 4669: 4667: 4663: 4624: 4618: 4605: 4595: 4593: 4550: 4543: 4506: 4499: 4468: 4459: 4428: 4421: 4389: 4382: 4374: 4368:GlaxoSmithKline 4363: 4359: 4358: 4345: 4306: 4302: 4279: 4272: 4233: 4224: 4193:(10): 913–917. 4179: 4172: 4127: 4100: 4093: 4079: 4075: 4047: 4040: 3995: 3988: 3978: 3976: 3963: 3962: 3953: 3943: 3941: 3928: 3927: 3923: 3913: 3911: 3906:. 2 June 2020. 3898: 3897: 3890: 3880: 3878: 3865: 3864: 3860: 3850: 3848: 3835: 3834: 3813: 3803: 3801: 3788: 3787: 3783: 3773: 3771: 3756: 3755: 3751: 3741: 3739: 3724: 3723: 3719: 3709: 3707: 3689: 3685: 3675: 3673: 3664: 3663: 3659: 3649: 3647: 3635: 3634: 3630: 3585: 3576: 3537: 3490: 3480: 3478: 3465: 3464: 3460: 3455: 3443: 3431: 3423: 3407: 3398: 3393: 3333:GlaxoSmithKline 3313: 3304: 3303: 3302: 3299: 3298: 3297: 3296: 3293: 3291: 3288: 3286: 3283: 3279: 3264: 3238: 3188: 3182: 3178: 3164:Bupropion is a 3155:optical isomers 3149:-bupropion and 3095: 3083:psychostimulant 3060:-hydrobupropion 3053:-hydrobupropion 3009:cytochrome P450 2994:bioavailability 2991: 2986: 2971: 2929:phenethylamines 2924: 2920: 2917: 2911:receptors with 2910: 2905: 2901: 2892: 2858: 2855:methylphenidate 2846: 2797:-hydrobupropion 2790:-hydrobupropion 2751: 2739: 2735: 2731: 2727: 2721: 2719: 2705: 2694: 2681: 2659: 2645: 2633: 2619: 2615: 2603: 2589: 2585: 2573: 2559: 2555: 2543: 2529: 2525: 2513: 2499: 2487: 2477: 2465: 2455: 2443: 2429: 2417: 2403: 2393: 2391: 2389: 2385: 2381: 2380: 2376: 2375: 2371: 2370: 2363: 2361: 2359: 2353: 2342: 2340: 2338: 2334: 2330: 2329: 2325: 2324: 2320: 2319: 2312: 2310: 2308: 2302: 2291: 2289: 2287: 2283: 2279: 2278: 2274: 2273: 2269: 2268: 2261: 2259: 2257: 2251: 2224: 2199: 2172: 2168: 2142: 2138: 2112: 2108: 2028: 1982: 1966: 1964: 1954: 1952: 1942: 1940: 1930: 1928: 1909: 1886:corticosteroids 1884:, and systemic 1729: 1697: 1654: 1591: 1585: 1553:bulimia nervosa 1537: 1528: 1524: 1516: 1512: 1500: 1496: 1491: 1487: 1483: 1462: 1452: 1450:Available forms 1437:clinical trials 1421:akinetic mutism 1389: 1364: 1332: 1324:methylphenidate 1312:onset of action 1296: 1260: 1186: 1173: 1160: 1051:adverse effects 1021:and to support 991: 989: 984: 981: 976: 971: 970: 959: 956: 951: 950: 939: 914: 895: 889: 869: 845: 837: 817: 797: 769: 749: 729: 709: 689: 672: 664: 656: 650: 632: 629: 616: 615: 595: 591: 587: 583: 566: 562: 560: 556: 552: 550: 546: 542: 540: 536: 532: 525: 515: 513: 507: 505: 499: 497: 491: 458: 456: 451:Protein binding 441:Bioavailability 433:Pharmacokinetic 427: 408: 332: 306:antidepressants 284: 277: 258: 251: 189:-butylcathinone 180: 170: 137: 133: 127: 123: 84: 80: 67: 39: 28: 23: 22: 15: 12: 11: 5: 27540: 27530: 27529: 27524: 27519: 27514: 27509: 27504: 27499: 27494: 27489: 27484: 27479: 27477:Ergogenic aids 27474: 27469: 27464: 27459: 27454: 27449: 27444: 27439: 27434: 27429: 27424: 27409: 27408: 27385: 27384: 27382: 27381: 27368: 27365: 27364: 27362: 27361: 27356: 27349: 27344: 27338: 27336: 27332: 27331: 27329: 27328: 27321: 27314: 27307: 27300: 27292: 27290: 27286: 27285: 27282: 27281: 27279: 27278: 27273: 27268: 27266:Henry Wellcome 27263: 27258: 27253: 27248: 27246:Thomas Beecham 27242: 27240: 27236: 27235: 27233: 27232: 27227: 27222: 27217: 27214: 27212:Lynn Elsenhans 27209: 27204: 27199: 27194: 27189: 27184: 27179: 27177:Philip Hampton 27173: 27171: 27162: 27158: 27157: 27154: 27153: 27151: 27150: 27145: 27140: 27135: 27130: 27125: 27120: 27115: 27110: 27105: 27103:Goody's Powder 27100: 27095: 27092: 27087: 27082: 27077: 27072: 27067: 27062: 27057: 27052: 27047: 27044: 27038: 27036: 27032: 27031: 27028: 27027: 27025: 27024: 27013: 27008: 27003: 26998: 26993: 26988: 26983: 26978: 26973: 26968: 26963: 26958: 26953: 26948: 26943: 26938: 26933: 26928: 26923: 26917: 26915: 26911: 26910: 26908: 26907: 26896: 26891: 26886: 26881: 26876: 26871: 26866: 26861: 26856: 26851: 26846: 26841: 26836: 26831: 26825: 26823: 26816: 26809: 26805: 26804: 26802: 26801: 26796: 26791: 26786: 26781: 26776: 26771: 26769:Glaxo Wellcome 26766: 26761: 26756: 26751: 26746: 26740: 26738: 26732: 26731: 26728: 26727: 26722: 26720: 26716: 26715: 26713: 26712: 26706: 26701: 26696: 26691: 26685: 26683: 26676: 26672: 26671: 26664: 26663: 26656: 26649: 26641: 26632: 26631: 26629: 26628: 26623: 26618: 26613: 26608: 26603: 26600:Levosalbutamol 26593: 26588: 26583: 26578: 26573: 26568: 26563: 26558: 26553: 26548: 26543: 26538: 26533: 26528: 26523: 26518: 26513: 26508: 26503: 26498: 26493: 26488: 26483: 26481:Desvenlafaxine 26478: 26473: 26468: 26463: 26458: 26452: 26450: 26446: 26445: 26443: 26442: 26437: 26432: 26424: 26416: 26411: 26406: 26396: 26394:Norepinephrine 26391: 26381: 26376: 26371: 26366: 26361: 26356: 26351: 26343: 26335: 26333:-Phenylalanine 26327: 26318: 26309: 26304: 26299: 26294: 26289: 26284: 26279: 26274: 26269: 26264: 26259: 26250: 26245: 26240: 26235: 26230: 26225: 26219: 26217: 26211:Catecholamines 26207: 26206: 26204: 26203: 26198: 26193: 26188: 26183: 26178: 26173: 26168: 26163: 26158: 26153: 26148: 26143: 26138: 26133: 26128: 26123: 26118: 26113: 26104: 26102: 26096: 26095: 26093: 26092: 26080: 26075: 26070: 26065: 26060: 26055: 26050: 26041: 26039: 26033: 26032: 26030: 26029: 26024: 26019: 26014: 26009: 26004: 25999: 25987: 25982: 25977: 25972: 25967: 25962: 25957: 25952: 25947: 25942: 25937: 25932: 25927: 25922: 25917: 25912: 25907: 25902: 25897: 25892: 25887: 25882: 25877: 25872: 25867: 25862: 25853: 25851: 25845: 25844: 25842: 25841: 25829: 25817: 25812: 25807: 25802: 25797: 25792: 25783: 25781: 25775: 25774: 25772: 25771: 25758: 25753: 25748: 25736: 25731: 25726: 25724:Methamnetamine 25721: 25716: 25711: 25706: 25701: 25696: 25691: 25686: 25681: 25676: 25671: 25666: 25661: 25656: 25651: 25646: 25641: 25636: 25631: 25626: 25621: 25616: 25611: 25606: 25601: 25596: 25584: 25579: 25574: 25569: 25564: 25559: 25554: 25549: 25544: 25539: 25534: 25529: 25524: 25519: 25514: 25509: 25504: 25499: 25494: 25489: 25484: 25479: 25471: 25466: 25461: 25456: 25451: 25441: 25436: 25431: 25426: 25421: 25416: 25411: 25406: 25401: 25396: 25391: 25386: 25381: 25376: 25362: 25357: 25352: 25347: 25345:Etilamfetamine 25342: 25337: 25332: 25327: 25322: 25317: 25312: 25307: 25293: 25288: 25283: 25278: 25273: 25268: 25263: 25258: 25246: 25241: 25236: 25231: 25226: 25221: 25216: 25211: 25206: 25201: 25196: 25191: 25186: 25181: 25176: 25171: 25166: 25161: 25156: 25151: 25146: 25141: 25136: 25131: 25126: 25121: 25116: 25107: 25105: 25099: 25098: 25096: 25095: 25090: 25078: 25073: 25064: 25063: 25058: 25050: 25042: 25034: 25026: 25021: 25015: 25010: 25008:Phenethylamine 25005: 24990: 24989: 24984: 24979: 24974: 24969: 24964: 24959: 24954: 24949: 24944: 24939: 24934: 24929: 24923: 24922: 24917: 24912: 24907: 24902: 24897: 24892: 24887: 24882: 24877: 24872: 24867: 24862: 24857: 24852: 24847: 24842: 24837: 24832: 24827: 24822: 24817: 24812: 24807: 24802: 24797: 24792: 24787: 24782: 24777: 24772: 24767: 24762: 24757: 24752: 24747: 24742: 24737: 24732: 24727: 24722: 24717: 24712: 24707: 24702: 24697: 24692: 24687: 24682: 24677: 24672: 24667: 24662: 24657: 24652: 24647: 24642: 24637: 24632: 24627: 24622: 24617: 24612: 24607: 24602: 24596: 24595: 24590: 24585: 24580: 24575: 24566: 24564: 24558: 24557: 24550: 24549: 24542: 24535: 24527: 24518: 24517: 24507: 24504: 24503: 24501: 24500: 24495: 24490: 24485: 24480: 24475: 24470: 24465: 24460: 24455: 24450: 24445: 24440: 24435: 24430: 24425: 24415: 24410: 24405: 24400: 24395: 24390: 24388:Chlorpromazine 24385: 24380: 24375: 24370: 24365: 24360: 24351: 24350: 24341: 24340: 24335: 24330: 24325: 24320: 24315: 24310: 24305: 24300: 24295: 24290: 24285: 24276: 24275: 24270: 24265: 24260: 24255: 24250: 24245: 24236: 24234: 24230: 24229: 24227: 24226: 24221: 24216: 24211: 24201: 24196: 24191: 24186: 24181: 24176: 24171: 24166: 24156: 24146: 24141: 24136: 24131: 24126: 24121: 24112: 24111: 24106: 24101: 24096: 24091: 24086: 24081: 24076: 24071: 24062: 24061: 24056: 24051: 24046: 24041: 24036: 24031: 24026: 24018: 24013: 24008: 24003: 23998: 23993: 23988: 23983: 23978: 23973: 23964: 23962: 23958: 23953: 23952: 23950: 23949: 23944: 23939: 23934: 23929: 23924: 23919: 23914: 23909: 23904: 23899: 23894: 23889: 23884: 23879: 23874: 23864: 23854: 23846: 23841: 23836: 23831: 23829:Chlorpromazine 23826: 23821: 23816: 23811: 23806: 23801: 23796: 23791: 23786: 23781: 23772: 23771: 23766: 23750: 23749: 23744: 23739: 23734: 23729: 23724: 23719: 23714: 23709: 23704: 23699: 23694: 23689: 23684: 23682:E-52862 (S1RA) 23679: 23674: 23669: 23664: 23659: 23654: 23649: 23644: 23639: 23634: 23629: 23624: 23615: 23614: 23609: 23604: 23599: 23594: 23589: 23584: 23579: 23574: 23569: 23564: 23559: 23554: 23549: 23547:Neuropeptide Y 23544: 23539: 23534: 23529: 23524: 23519: 23511: 23506: 23501: 23496: 23491: 23486: 23481: 23476: 23471: 23466: 23461: 23456: 23451: 23446: 23441: 23436: 23431: 23429:Dextrallorphan 23426: 23416: 23406: 23401: 23396: 23391: 23386: 23376: 23371: 23366: 23361: 23356: 23351: 23346: 23341: 23336: 23331: 23326: 23317: 23315: 23311: 23306: 23305: 23299:Sigma receptor 23295: 23294: 23287: 23280: 23272: 23263: 23262: 23260: 23259: 23250: 23241: 23228: 23219: 23210: 23201: 23188: 23185: 23184: 23181: 23180: 23177: 23176: 23174: 23173: 23163: 23145: 23142: 23141: 23139: 23138: 23133: 23114:chlorpromazine 23110:acetophenazine 23103: 23085: 23063: 23058: 23053: 23048: 23043: 23038: 23033: 23028: 23023: 23018: 23013: 23008: 23003: 22998: 22993: 22988: 22934: 22929: 22924: 22919: 22857: 22854: 22853: 22851: 22850: 22828: 22818: 22813: 22808: 22803: 22798: 22793: 22788: 22778: 22773: 22768: 22763: 22754: 22748: 22744: 22739: 22738: 22735: 22734: 22732: 22731: 22721: 22695: 22692: 22691: 22689: 22688: 22681:chlorpromazine 22674: 22652: 22638: 22633: 22628: 22623: 22618: 22613: 22608: 22603: 22598: 22593: 22588: 22583: 22578: 22573: 22568: 22563: 22558: 22553: 22548: 22543: 22538: 22533: 22528: 22523: 22518: 22513: 22508: 22470: 22461: 22458: 22457: 22455: 22454: 22449: 22444: 22386: 22381: 22376: 22334: 22328: 22324: 22319: 22318: 22315: 22314: 22312: 22311: 22301: 22283: 22282: 22277: 22272: 22267: 22262: 22253: 22250: 22249: 22247: 22246: 22244:Valerenic acid 22241: 22231: 22226: 22204: 22198: 22194: 22189: 22188: 22185: 22184: 22182: 22181: 22176: 22171: 22166: 22161: 22156: 22151: 22146: 22137: 22134: 22133: 22131: 22130: 22125: 22120: 22115: 22110: 22105: 22100: 22095: 22090: 22085: 22080: 22075: 22070: 22068:Metoclopramide 22065: 22060: 22055: 22050: 22045: 22040: 22035: 22026: 22020: 22016: 22011: 22010: 22007: 22006: 22004: 22003: 21993: 21984: 21981: 21980: 21978: 21977: 21972: 21967: 21962: 21944: 21934: 21929: 21924: 21919: 21901: 21896: 21891: 21886: 21881: 21876: 21871: 21866: 21861: 21856: 21851: 21846: 21841: 21836: 21831: 21826: 21821: 21816: 21811: 21806: 21788: 21783: 21778: 21773: 21764: 21761: 21760: 21758: 21757: 21752: 21730: 21712: 21707: 21702: 21697: 21692: 21674: 21669: 21664: 21642: 21636: 21632: 21624: 21618: 21614: 21609: 21608: 21605: 21604: 21601: 21600: 21598: 21597: 21583: 21574: 21571: 21570: 21568: 21567: 21562: 21543:chlorpromazine 21536: 21522: 21517: 21512: 21507: 21477: 21472: 21467: 21462: 21457: 21452: 21447: 21442: 21437: 21432: 21427: 21422: 21417: 21412: 21407: 21402: 21397: 21392: 21387: 21382: 21377: 21372: 21367: 21362: 21357: 21319: 21314: 21309: 21304: 21299: 21297:Cyproheptadine 21294: 21289: 21284: 21279: 21221: 21216: 21207: 21204: 21203: 21201: 21200: 21195: 21190: 21185: 21180: 21134: 21129: 21124: 21119: 21114: 21109: 21083: 21069: 21064: 21059: 21054: 21049: 21044: 21022: 21017: 21012: 20954: 20932: 20927: 20922: 20917: 20912: 20907: 20873: 20847: 20813: 20807: 20803: 20798: 20797: 20794: 20793: 20791: 20790: 20776: 20773: 20772: 20770: 20769: 20764: 20759: 20756:chlorpromazine 20749: 20744: 20726: 20721: 20716: 20711: 20706: 20701: 20696: 20691: 20686: 20681: 20676: 20671: 20666: 20661: 20656: 20651: 20646: 20641: 20636: 20631: 20626: 20621: 20591: 20586: 20584:Cyproheptadine 20581: 20523: 20514: 20511: 20510: 20508: 20507: 20453: 20448: 20443: 20438: 20428: 20406: 20401: 20367: 20345: 20340: 20310: 20305: 20296: 20290: 20286: 20281: 20280: 20277: 20276: 20274: 20273: 20255: 20252: 20251: 20249: 20248: 20243: 20238: 20233: 20178:chlorpromazine 20171: 20161: 20131: 20126: 20121: 20116: 20111: 20077: 20072: 20067: 20062: 20057: 20052: 20047: 20042: 20037: 20032: 20027: 20022: 20017: 20012: 20007: 20002: 19997: 19992: 19987: 19982: 19977: 19972: 19967: 19962: 19957: 19952: 19947: 19942: 19908: 19903: 19898: 19893: 19888: 19883: 19878: 19776: 19771: 19756:cyproheptadine 19752:Antihistamines 19749: 19744: 19739: 19734: 19729: 19720: 19717: 19716: 19714: 19713: 19667: 19662: 19657: 19652: 19634: 19620: 19618:SCHEMBL5334361 19615: 19610: 19605: 19600: 19595: 19590: 19585: 19563: 19558: 19553: 19548: 19543: 19473: 19468: 19446: 19441: 19436: 19431: 19426: 19421: 19387: 19361: 19356: 19351: 19321: 19274: 19268: 19264: 19256: 19252: 19247: 19246: 19243: 19242: 19239: 19238: 19236: 19235: 19230: 19221: 19218: 19217: 19215: 19214: 19204: 19186: 19181: 19176: 19171: 19150: 19145: 19136: 19130: 19126: 19121: 19120: 19117: 19116: 19114: 19113: 19092: 19089: 19088: 19086: 19085: 19076: 19073: 19072: 19070: 19069: 19059: 19049: 19044: 19034: 19025: 19019: 19015: 19010: 19009: 19006: 19005: 19003: 19002: 18984: 18975: 18972: 18971: 18969: 18968: 18963: 18958: 18953: 18948: 18943: 18938: 18933: 18928: 18923: 18918: 18913: 18908: 18898: 18893: 18888: 18879: 18876: 18875: 18873: 18872: 18842: 18800: 18795: 18790: 18785: 18780: 18775: 18770: 18765: 18760: 18730: 18725: 18720: 18711: 18705: 18701: 18696: 18695: 18692: 18691: 18689: 18688: 18666: 18663: 18662: 18660: 18659: 18654: 18649: 18644: 18639: 18634: 18629: 18624: 18619: 18609: 18604: 18570: 18561: 18558: 18557: 18555: 18554: 18549: 18527: 18522: 18496: 18491: 18486: 18481: 18451: 18446: 18441: 18436: 18431: 18426: 18421: 18412: 18406: 18402: 18397: 18396: 18393: 18392: 18390: 18389: 18379: 18374: 18365: 18362: 18361: 18359: 18358: 18353: 18348: 18343: 18338: 18333: 18328: 18323: 18318: 18313: 18308: 18303: 18298: 18293: 18288: 18283: 18278: 18273: 18268: 18263: 18258: 18253: 18243: 18238: 18233: 18228: 18178: 18173: 18151: 18148: 18147: 18145: 18144: 18139: 18134: 18129: 18124: 18119: 18114: 18072: 18067: 18062: 18057: 18052: 18047: 18042: 18037: 18032: 18027: 18022: 18017: 18012: 18007: 18002: 17997: 17992: 17987: 17982: 17977: 17972: 17967: 17962: 17957: 17952: 17947: 17942: 17937: 17932: 17927: 17922: 17917: 17912: 17870: 17865: 17860: 17855: 17850: 17845: 17840: 17835: 17830: 17825: 17799: 17761: 17727: 17722: 17717: 17708: 17702: 17698: 17690: 17686: 17681: 17680: 17670: 17669: 17662: 17655: 17647: 17638: 17637: 17635: 17634: 17629: 17624: 17619: 17615: 17612: 17611: 17609: 17608: 17603: 17598: 17593: 17588: 17583: 17578: 17573: 17568: 17563: 17553: 17548: 17542: 17540: 17526: 17525: 17522: 17521: 17519: 17518: 17513: 17508: 17503: 17498: 17493: 17488: 17483: 17478: 17473: 17468: 17463: 17458: 17453: 17448: 17443: 17438: 17433: 17428: 17423: 17418: 17413: 17408: 17403: 17398: 17393: 17388: 17383: 17378: 17373: 17368: 17363: 17358: 17353: 17348: 17343: 17338: 17333: 17328: 17323: 17318: 17313: 17308: 17306:Kynurenic acid 17303: 17298: 17293: 17288: 17283: 17278: 17273: 17268: 17263: 17258: 17253: 17248: 17243: 17238: 17233: 17228: 17223: 17218: 17213: 17208: 17203: 17198: 17193: 17188: 17183: 17178: 17173: 17168: 17163: 17158: 17153: 17148: 17143: 17138: 17133: 17128: 17123: 17118: 17113: 17108: 17103: 17100:κ-bungarotoxin 17096:α-bungarotoxin 17089: 17084: 17070: 17065: 17060: 17055: 17050: 17045: 17040: 17035: 17034:, many others) 17024:α-bungarotoxin 17017: 17012: 17006: 17004: 16987: 16986: 16984: 16983: 16978: 16973: 16968: 16963: 16958: 16956:Tribendimidine 16953: 16948: 16943: 16938: 16933: 16928: 16923: 16918: 16913: 16908: 16903: 16898: 16893: 16888: 16883: 16881:Sebacylcholine 16878: 16873: 16868: 16863: 16858: 16853: 16848: 16843: 16838: 16833: 16828: 16823: 16813: 16808: 16803: 16798: 16793: 16788: 16783: 16778: 16773: 16768: 16763: 16758: 16753: 16748: 16743: 16738: 16733: 16728: 16723: 16718: 16713: 16708: 16703: 16698: 16696:Butyrylcholine 16693: 16688: 16683: 16678: 16673: 16668: 16663: 16658: 16653: 16648: 16643: 16638: 16633: 16628: 16623: 16618: 16613: 16608: 16602: 16600: 16580: 16569: 16568: 16558: 16557: 16550: 16543: 16535: 16526: 16525: 16489: 16486: 16485: 16483: 16482: 16470: 16458: 16457: 16452:DAT enhancers: 16448: 16446: 16442: 16441: 16439: 16438: 16433: 16428: 16423: 16418: 16413: 16408: 16403: 16398: 16393: 16388: 16383: 16378: 16373: 16368: 16363: 16358: 16353: 16348: 16330: 16324: 16322: 16311: 16310: 16307: 16306: 16304: 16303: 16298: 16268: 16263: 16258: 16253: 16248: 16243: 16238: 16233: 16228: 16223: 16218: 16213: 16187: 16176:Antipsychotics 16173: 16170:tripelennamine 16154:dimenhydrinate 16150:chlorphenamine 16142:Antihistamines 16139: 16134: 16125: 16122: 16121: 16119: 16118: 16113: 16108: 16103: 16098: 16093: 16088: 16083: 16078: 16076:Cyanodothiepin 16073: 16068: 16063: 16054: 16051: 16050: 16048: 16047: 16037: 16032: 16027: 16022: 16017: 16012: 16007: 16002: 15997: 15992: 15987: 15982: 15977: 15972: 15967: 15962: 15957: 15952: 15947: 15942: 15937: 15932: 15927: 15922: 15917: 15912: 15907: 15902: 15897: 15892: 15887: 15882: 15877: 15872: 15867: 15862: 15853: 15850: 15849: 15847: 15846: 15841: 15836: 15831: 15826: 15821: 15816: 15811: 15806: 15801: 15799:Desvenlafaxine 15796: 15791: 15786: 15777: 15774: 15773: 15771: 15770: 15765: 15760: 15755: 15750: 15745: 15740: 15735: 15730: 15725: 15716: 15715: 15710: 15705: 15700: 15695: 15690: 15685: 15680: 15675: 15670: 15665: 15660: 15655: 15650: 15645: 15640: 15635: 15630: 15625: 15620: 15615: 15610: 15605: 15600: 15591: 15585: 15561: 15560: 15557: 15556: 15554: 15553: 15523: 15518: 15513: 15506: 15501: 15496: 15482: 15471:Antipsychotics 15468: 15465:tripelennamine 15457:chlorphenamine 15449:Antihistamines 15442: 15439: 15438: 15436: 15435: 15430: 15425: 15420: 15415: 15406: 15403: 15402: 15400: 15399: 15394: 15389: 15384: 15379: 15374: 15369: 15364: 15359: 15354: 15349: 15344: 15339: 15330: 15327: 15326: 15324: 15323: 15313: 15308: 15303: 15298: 15293: 15288: 15283: 15278: 15273: 15268: 15263: 15258: 15253: 15248: 15243: 15238: 15233: 15228: 15223: 15218: 15213: 15208: 15203: 15198: 15193: 15188: 15183: 15178: 15173: 15168: 15163: 15158: 15153: 15148: 15143: 15138: 15129: 15126: 15125: 15123: 15122: 15117: 15112: 15107: 15102: 15097: 15092: 15087: 15082: 15077: 15072: 15070:Desvenlafaxine 15067: 15062: 15053: 15050: 15049: 15047: 15046: 15041: 15036: 15031: 15026: 15021: 15016: 15011: 15006: 15001: 14996: 14991: 14986: 14981: 14976: 14967: 14964: 14963: 14961: 14960: 14955: 14950: 14945: 14940: 14935: 14930: 14925: 14920: 14915: 14910: 14905: 14900: 14895: 14890: 14881: 14875: 14851: 14850: 14847: 14846: 14844: 14843: 14838: 14836:Tripelennamine 14833: 14828: 14823: 14818: 14813: 14808: 14803: 14798: 14793: 14788: 14783: 14778: 14773: 14768: 14763: 14758: 14753: 14748: 14743: 14738: 14733: 14728: 14723: 14718: 14713: 14708: 14703: 14698: 14693: 14688: 14683: 14678: 14673: 14668: 14663: 14658: 14653: 14648: 14643: 14638: 14633: 14628: 14623: 14618: 14613: 14608: 14603: 14598: 14593: 14586: 14581: 14576: 14571: 14566: 14561: 14559:Amfonelic acid 14556: 14551: 14546: 14537: 14534: 14533: 14531: 14530: 14525: 14520: 14515: 14510: 14505: 14500: 14495: 14490: 14485: 14480: 14475: 14470: 14465: 14460: 14455: 14450: 14445: 14440: 14435: 14430: 14425: 14420: 14415: 14410: 14405: 14400: 14391: 14388: 14387: 14385: 14384: 14379: 14374: 14369: 14364: 14355: 14352: 14351: 14349: 14348: 14343: 14338: 14333: 14328: 14323: 14318: 14313: 14311:Ethylphenidate 14308: 14303: 14298: 14293: 14288: 14279: 14276: 14275: 14273: 14272: 14267: 14262: 14257: 14252: 14247: 14242: 14237: 14228: 14222: 14198: 14197: 14190: 14189: 14182: 14175: 14167: 14158: 14157: 14155: 14154: 14143: 14140: 14139: 14137: 14136: 14124: 14119: 14107: 14089: 14084: 14079: 14074: 14069: 14064: 14059: 14054: 14052:Cyproheptadine 14049: 14044: 14039: 14034: 14029: 14027:Alkyl nitrites 14024: 14005: 14003: 13999: 13998: 13996: 13995: 13988: 13974: 13952: 13933: 13931: 13925: 13924: 13922: 13921: 13916: 13911: 13906: 13901: 13896: 13891: 13886: 13881: 13876: 13871: 13866: 13860: 13858: 13852: 13851: 13849: 13848: 13843: 13838: 13832: 13830: 13824: 13823: 13821: 13820: 13815: 13810: 13805: 13800: 13795: 13790: 13785: 13780: 13775: 13769: 13767: 13761: 13760: 13750: 13749: 13742: 13735: 13727: 13718: 13717: 13714: 13713: 13712: 13711: 13708: 13697: 13691: 13685: 13684: 13681: 13680: 13678: 13677: 13672: 13667: 13662: 13657: 13652: 13647: 13642: 13637: 13632: 13627: 13621: 13619: 13615: 13614: 13612: 13611: 13605: 13603: 13597: 13596: 13594: 13593: 13588: 13583: 13578: 13573: 13567: 13565: 13561: 13560: 13558: 13557: 13552: 13546: 13544: 13536: 13535: 13533: 13532: 13521: 13519: 13513: 13512: 13510: 13509: 13503: 13493: 13488: 13483: 13478: 13473: 13467: 13462: 13457: 13452: 13447: 13441: 13439: 13421: 13420: 13418: 13417: 13412: 13407: 13402: 13397: 13392: 13387: 13381: 13379: 13371: 13370: 13367: 13366: 13364: 13363: 13358: 13353: 13348: 13343: 13338: 13333: 13328: 13326:Phenethylamine 13323: 13318: 13313: 13308: 13303: 13293: 13288: 13283: 13278: 13273: 13263: 13258: 13253: 13247: 13245: 13241: 13240: 13238: 13237: 13227: 13222: 13217: 13212: 13207: 13202: 13197: 13191: 13189: 13183: 13182: 13180: 13179: 13174: 13169: 13159: 13154: 13149: 13144: 13139: 13134: 13129: 13124: 13119: 13114: 13109: 13104: 13102:Etilamfetamine 13099: 13094: 13089: 13084: 13079: 13074: 13069: 13064: 13059: 13054: 13049: 13044: 13039: 13034: 13029: 13024: 13019: 13013: 13011: 12997: 12991: 12990: 12974: 12973: 12966: 12959: 12951: 12942: 12941: 12939: 12938: 12926: 12920: 12915: 12910: 12899: 12881: 12879: 12873: 12872: 12870: 12869: 12863: 12852: 12851: 12850: 12845: 12840: 12835: 12833:Dihydrocodeine 12830: 12825: 12820: 12803: 12798: 12792: 12775: 12773: 12767: 12766: 12764: 12763: 12758: 12753: 12736: 12731: 12730: 12729: 12724: 12712: 12711: 12710: 12698: 12697: 12696: 12691: 12686: 12681: 12665: 12663: 12657: 12656: 12654: 12653: 12636: 12631: 12626: 12621: 12616: 12610: 12608: 12602: 12601: 12588: 12587: 12580: 12573: 12565: 12556: 12555: 12552: 12551: 12550: 12549: 12546: 12535: 12529: 12523: 12522: 12519: 12518: 12515: 12514: 12512: 12511: 12506: 12501: 12492: 12484: 12467: 12461:Ademetionine ( 12457: 12454: 12453: 12443: 12442: 12439: 12438: 12436: 12435: 12431: 12423: 12413: 12399: 12394: 12363: 12360: 12359: 12347: 12346: 12343: 12342: 12339: 12338: 12336: 12335: 12326: 12324: 12315: 12309: 12308: 12306: 12305: 12300: 12295: 12290: 12285: 12280: 12275: 12266: 12264: 12255: 12249: 12248: 12246: 12245: 12236: 12235: 12226: 12225: 12220: 12215: 12210: 12205: 12200: 12195: 12190: 12185: 12180: 12175: 12170: 12165: 12160: 12155: 12150: 12141: 12139: 12131: 12130: 12118: 12117: 12114: 12113: 12110: 12109: 12107: 12106: 12100: 12098: 12094: 12093: 12091: 12090: 12085: 12080: 12075: 12069: 12067: 12056: 12055: 12053: 12052: 12047: 12042: 12037: 12032: 12027: 12022: 12017: 12012: 12007: 12002: 11997: 11992: 11987: 11982: 11980:Imipraminoxide 11977: 11972: 11967: 11962: 11957: 11952: 11947: 11942: 11937: 11932: 11927: 11922: 11917: 11911: 11909: 11894: 11893: 11877: 11876: 11873: 11872: 11869: 11868: 11866: 11865: 11860: 11855: 11850: 11845: 11840: 11835: 11830: 11825: 11820: 11815: 11810: 11805: 11800: 11795: 11790: 11784: 11782: 11778: 11777: 11775: 11774: 11769: 11763: 11761: 11750: 11749: 11747: 11746: 11741: 11736: 11730: 11728: 11717: 11716: 11714: 11713: 11708: 11703: 11697: 11695: 11684: 11683: 11681: 11680: 11675: 11670: 11664: 11662: 11651: 11650: 11648: 11647: 11642: 11637: 11631: 11629: 11618: 11617: 11615: 11614: 11609: 11604: 11599: 11594: 11589: 11587:Desvenlafaxine 11583: 11581: 11570: 11569: 11567: 11566: 11561: 11556: 11551: 11546: 11541: 11536: 11531: 11525: 11523: 11508: 11507: 11490: 11489: 11477: 11476: 11469: 11462: 11454: 11446: 11445: 11424:(2): 111–113. 11404: 11385:(4): 276–277. 11369: 11350:(4): 615–625. 11334: 11327: 11309: 11279: 11272: 11254: 11232:(in Russian). 11221: 11194:(5): 357–362. 11178: 11159:(3): 216–217. 11143: 11100: 11081: 11044: 11017:(4): 341–354. 10998: 10967: 10937: 10900: 10869: 10838: 10804: 10764: 10734: 10700: 10669: 10624: 10613:on 6 June 2011 10592: 10559: 10533: 10507: 10467: 10433: 10399: 10361: 10335: 10309: 10274: 10245:(2): 105–108. 10225: 10184: 10135: 10121: 10101: 10072: 10044: 10025:(7): 495–500. 10009: 9990:(4): 341–354. 9974: 9955:(3): 287–298. 9936: 9917:(3): 293–313. 9911:Drug Metab Rev 9898: 9883: 9850: 9841: 9830:(4): 637–643. 9814: 9795:(4): 225–238. 9778: 9771: 9751: 9697: 9651: 9615: 9566: 9523: 9480: 9439: 9387: 9348: 9329:(1): 134–144. 9313: 9276:Front Neurosci 9262: 9226: 9184: 9165:(4): 387–394. 9144: 9090: 9063:(6): 820–830. 9047: 9018:(1): 260–266. 8998: 8979:(2): 155–169. 8956: 8947: 8928:(3): 675–682. 8911: 8892:(4): 467–489. 8876: 8841: 8822:(4): 559–565. 8806: 8771: 8744: 8716: 8687: 8667: 8650: 8601: 8572:(3): 171–179. 8552: 8525:(3): 675–682. 8505: 8470: 8443:(4): 467–489. 8422: 8364: 8321: 8272: 8237: 8202: 8145: 8116:(1): 102–111. 8096: 8075:(2): 198–207. 8055: 8014: 7995:(5): 327–333. 7979: 7933: 7904:(4): 238–250. 7884: 7877: 7859: 7810: 7776: 7727: 7700: 7651: 7608: 7572: 7523: 7480: 7441:(3): 296–303. 7421: 7377: 7347: 7310: 7285:J Investig Med 7275: 7256:(2): 181–188. 7240: 7205: 7171: 7122: 7091:(8): 897–905. 7071: 7030: 6979: 6943: 6908: 6859: 6829: 6795: 6774:(7): 532–546. 6751: 6694: 6673:(1): 114–128. 6653: 6604: 6569:Women's Health 6555: 6526:(4): 159–166. 6506: 6479:(3): 259–266. 6463: 6411: 6392:(2): 112–116. 6376: 6347:(9): 727–738. 6327: 6268: 6219: 6170: 6129: 6108:(3): 280–298. 6088: 6039: 6010:(5): 805–816. 5990: 5963:(7): 965–981. 5942: 5891: 5839: 5788: 5737: 5708:(5): 545–546. 5688: 5641: 5630:on 4 June 2020 5606: 5557: 5508: 5467: 5416: 5364: 5300: 5246: 5164: 5120: 5092: 5067: 5037: 4994: 4962: 4943: 4920: 4887: 4860:(4): 481–488. 4839: 4812: 4785: 4725: 4710: 4677: 4635:(8): 561–628. 4603: 4564:(3): 291–312. 4541: 4520:(5): 438–450. 4497: 4478:(6): 612–617. 4457: 4438:(4): 404–415. 4419: 4400:(2): 253–259. 4380: 4343: 4316:(4): 121–135. 4300: 4270: 4243:(5): 653–689. 4222: 4170: 4098: 4091: 4073: 4038: 4009:(2): 230–238. 3986: 3951: 3921: 3888: 3858: 3811: 3781: 3749: 3717: 3683: 3657: 3628: 3599:(3): 106–113. 3574: 3547:(3): 293–313. 3488: 3457: 3456: 3454: 3451: 3450: 3449: 3442: 3439: 3430: 3427: 3422: 3419: 3406: 3403: 3397: 3394: 3392: 3389: 3366:Sanofi-Aventis 3319:Comparison of 3312: 3309: 3306: 3305: 3300: 3281: 3280: 3273: 3272: 3271: 3270: 3237: 3234: 3180: 3176: 3166:small-molecule 3094: 3091: 2989: 2984: 2970: 2967: 2915: 2908: 2903: 2899: 2890: 2757: 2756: 2749: 2737: 2733: 2729: 2725: 2717: 2710: 2709: 2706: 2703: 2700: 2697: 2686: 2685: 2682: 2679: 2676: 2673: 2664: 2663: 2660: 2657: 2654: 2651: 2643: 2638: 2637: 2634: 2631: 2628: 2625: 2617: 2613: 2608: 2607: 2604: 2601: 2598: 2595: 2587: 2583: 2578: 2577: 2574: 2571: 2568: 2565: 2557: 2553: 2548: 2547: 2544: 2541: 2538: 2535: 2527: 2523: 2518: 2517: 2514: 2511: 2508: 2505: 2497: 2492: 2491: 2488: 2485: 2482: 2479: 2475: 2470: 2469: 2466: 2463: 2460: 2457: 2453: 2448: 2447: 2444: 2441: 2438: 2435: 2427: 2422: 2421: 2418: 2415: 2412: 2409: 2401: 2396: 2395: 2386: 2383: 2378: 2373: 2368: 2365: 2356: 2345: 2344: 2335: 2332: 2327: 2322: 2317: 2314: 2305: 2294: 2293: 2284: 2281: 2276: 2271: 2266: 2263: 2254: 2243: 2242: 2239: 2236: 2233: 2223: 2220: 2217: 2216: 2213: 2210: 2207: 2204: 2201: 2197: 2192: 2191: 2188: 2185: 2182: 2179: 2176: 2170: 2166: 2161: 2160: 2157: 2154: 2151: 2148: 2145: 2140: 2136: 2131: 2130: 2127: 2124: 2121: 2118: 2115: 2110: 2106: 2101: 2100: 2097: 2094: 2091: 2088: 2085: 2078: 2077: 2074: 2071: 2068: 2065: 2062: 2055: 2054: 2051: 2048: 2045: 2042: 2039: 2032: 2031: 2026: 2020: 2019: 2016: 2013: 2010: 2007: 2004: 2000: 1999: 1996: 1993: 1990: 1987: 1984: 1975: 1974: 1970: 1969: 1957: 1945: 1933: 1921: 1918: 1908: 1905: 1874:antipsychotics 1789:St John's wort 1735:by the enzyme 1728: 1725: 1696: 1693: 1653: 1650: 1617:liver toxicity 1596:desvenlafaxine 1584: 1581: 1569:kidney disease 1557:benzodiazepine 1536: 1533: 1451: 1448: 1388: 1385: 1363: 1360: 1331: 1328: 1295: 1292: 1259: 1256: 1185: 1182: 1172: 1169: 1101:, and risk of 1095:liver toxicity 1087:blood pressure 998: 997: 986: 985: 983: 982: 979: 977: 974: 966: 965: 964: 961: 960: 958: 957: 954: 946: 945: 944: 941: 940: 938: 937: 929: 927: 919: 918: 912: 906: 905: 893: 887: 882: 876: 875: 871: 870: 868: 867: 854: 852: 839: 838: 836: 835: 827: 825: 819: 818: 816: 815: 807: 805: 799: 798: 796: 795: 787: 779: 777: 771: 770: 768: 767: 759: 757: 751: 750: 748: 747: 739: 737: 731: 730: 728: 727: 719: 717: 711: 710: 708: 707: 699: 697: 691: 690: 688: 687: 679: 677: 666: 665: 663: 662: 642: 640: 634: 633: 631: 630: 619: 611: 610: 609: 606: 605: 601: 600: 577: 571: 570: 529: 520: 519: 488: 482: 481: 467: 461: 460: 455:Bupropion: 84% 453: 447: 446: 443: 437: 436: 429: 428: 426: 425: 422: 413: 398: 385: 374: 361: 347: 345: 339: 338: 334: 333: 331: 330: 317: 315: 309: 308: 300: 294: 293: 287: 285:administration 279: 278: 276: 275: 273: 263: 261: 253: 252: 250: 249: 231: 229: 223: 222: 215: 209: 208: 201: 191: 190: 159: 155: 154: 151: 145: 144: 78: 74: 73: 69: 68: 65: 57: 56: 26: 9: 6: 4: 3: 2: 27539: 27528: 27525: 27523: 27520: 27518: 27515: 27513: 27510: 27508: 27505: 27503: 27500: 27498: 27495: 27493: 27490: 27488: 27485: 27483: 27480: 27478: 27475: 27473: 27470: 27468: 27465: 27463: 27460: 27458: 27455: 27453: 27450: 27448: 27445: 27443: 27440: 27438: 27435: 27433: 27430: 27428: 27425: 27423: 27420: 27419: 27417: 27407: 27397: 27396: 27393: 27380: 27379: 27370: 27369: 27366: 27360: 27357: 27355: 27354: 27350: 27348: 27345: 27343: 27340: 27339: 27337: 27333: 27327: 27326: 27322: 27320: 27319: 27315: 27313: 27312: 27308: 27306: 27305: 27301: 27299: 27298: 27294: 27293: 27291: 27287: 27277: 27274: 27272: 27269: 27267: 27264: 27262: 27261:John K. Smith 27259: 27257: 27254: 27252: 27249: 27247: 27244: 27243: 27241: 27237: 27231: 27228: 27226: 27223: 27221: 27218: 27216:Jesse Goodman 27215: 27213: 27210: 27208: 27205: 27203: 27200: 27198: 27195: 27193: 27190: 27188: 27185: 27183: 27182:Emma Walmsley 27180: 27178: 27175: 27174: 27172: 27166: 27163: 27159: 27149: 27146: 27144: 27141: 27139: 27136: 27134: 27131: 27129: 27126: 27124: 27121: 27119: 27116: 27114: 27111: 27109: 27106: 27104: 27101: 27099: 27096: 27093: 27091: 27088: 27086: 27083: 27081: 27078: 27076: 27073: 27071: 27068: 27066: 27063: 27061: 27058: 27056: 27053: 27051: 27048: 27045: 27043: 27040: 27039: 27037: 27033: 27023: 27022: 27017: 27014: 27012: 27009: 27007: 27004: 27002: 26999: 26997: 26994: 26992: 26989: 26987: 26984: 26982: 26979: 26977: 26974: 26972: 26969: 26967: 26964: 26962: 26959: 26957: 26954: 26952: 26949: 26947: 26944: 26942: 26939: 26937: 26934: 26932: 26929: 26927: 26924: 26922: 26919: 26918: 26916: 26912: 26906: 26905: 26900: 26897: 26895: 26892: 26890: 26887: 26885: 26882: 26880: 26877: 26875: 26874:Paxil/Seroxat 26872: 26870: 26867: 26865: 26862: 26860: 26857: 26855: 26852: 26850: 26847: 26845: 26842: 26840: 26837: 26835: 26832: 26830: 26827: 26826: 26824: 26820: 26817: 26813: 26810: 26806: 26800: 26797: 26795: 26792: 26790: 26787: 26785: 26782: 26780: 26777: 26775: 26772: 26770: 26767: 26765: 26762: 26760: 26757: 26755: 26752: 26750: 26749:Beecham Group 26747: 26745: 26742: 26741: 26739: 26735:Predecessors, 26733: 26725: 26721: 26717: 26710: 26707: 26705: 26702: 26700: 26697: 26695: 26692: 26690: 26687: 26686: 26684: 26680: 26677: 26673: 26669: 26662: 26657: 26655: 26650: 26648: 26643: 26642: 26639: 26627: 26624: 26622: 26619: 26617: 26616:Thiamphenicol 26614: 26612: 26611:Theodrenaline 26609: 26607: 26604: 26601: 26597: 26594: 26592: 26589: 26587: 26584: 26582: 26579: 26577: 26574: 26572: 26569: 26567: 26564: 26562: 26559: 26557: 26554: 26552: 26549: 26547: 26544: 26542: 26539: 26537: 26534: 26532: 26529: 26527: 26526:Fluorolintane 26524: 26522: 26519: 26517: 26514: 26512: 26509: 26507: 26504: 26502: 26499: 26497: 26494: 26492: 26489: 26487: 26484: 26482: 26479: 26477: 26474: 26472: 26469: 26467: 26464: 26462: 26459: 26457: 26454: 26453: 26451: 26449:Miscellaneous 26447: 26441: 26438: 26436: 26435:Phenylephrine 26433: 26431: 26429: 26425: 26423: 26421: 26417: 26415: 26414:Orciprenaline 26412: 26410: 26407: 26404: 26400: 26397: 26395: 26392: 26389: 26388:Levonordefrin 26385: 26382: 26380: 26377: 26375: 26372: 26370: 26367: 26365: 26362: 26360: 26357: 26355: 26352: 26350: 26348: 26344: 26342: 26336: 26334: 26328: 26325: 26319: 26316: 26310: 26308: 26305: 26303: 26300: 26298: 26295: 26293: 26290: 26288: 26285: 26283: 26280: 26278: 26275: 26273: 26270: 26268: 26265: 26263: 26260: 26257: 26251: 26249: 26246: 26244: 26241: 26239: 26236: 26234: 26231: 26229: 26226: 26224: 26221: 26220: 26218: 26212: 26208: 26202: 26199: 26197: 26194: 26192: 26189: 26187: 26184: 26182: 26179: 26177: 26174: 26172: 26169: 26167: 26164: 26162: 26159: 26157: 26154: 26152: 26149: 26147: 26144: 26142: 26139: 26137: 26134: 26132: 26129: 26127: 26124: 26122: 26119: 26117: 26114: 26112: 26109: 26106: 26105: 26103: 26101: 26097: 26091: 26088: 26084: 26081: 26079: 26076: 26074: 26071: 26069: 26066: 26064: 26061: 26059: 26056: 26054: 26051: 26049: 26046: 26043: 26042: 26040: 26038: 26034: 26028: 26025: 26023: 26020: 26018: 26015: 26013: 26010: 26008: 26005: 26003: 26000: 25998: 25995: 25991: 25988: 25986: 25983: 25981: 25978: 25976: 25973: 25971: 25968: 25966: 25963: 25961: 25958: 25956: 25955:Methcathinone 25953: 25951: 25948: 25946: 25943: 25941: 25938: 25936: 25933: 25931: 25928: 25926: 25923: 25921: 25918: 25916: 25913: 25911: 25908: 25906: 25903: 25901: 25898: 25896: 25893: 25891: 25888: 25886: 25883: 25881: 25878: 25876: 25873: 25871: 25868: 25866: 25863: 25861: 25858: 25855: 25854: 25852: 25850: 25846: 25840: 25837: 25833: 25830: 25828: 25825: 25821: 25818: 25816: 25813: 25811: 25810:Mephentermine 25808: 25806: 25803: 25801: 25798: 25796: 25793: 25791: 25788: 25785: 25784: 25782: 25780: 25776: 25769: 25762: 25759: 25757: 25754: 25752: 25749: 25747: 25744: 25740: 25737: 25735: 25732: 25730: 25727: 25725: 25722: 25720: 25717: 25715: 25712: 25710: 25707: 25705: 25702: 25700: 25697: 25695: 25692: 25690: 25687: 25685: 25682: 25680: 25677: 25675: 25672: 25670: 25667: 25665: 25662: 25660: 25659:6-Chloro-MDMA 25657: 25655: 25652: 25650: 25647: 25645: 25642: 25640: 25637: 25635: 25632: 25630: 25627: 25625: 25622: 25620: 25617: 25615: 25612: 25610: 25607: 25605: 25602: 25600: 25597: 25595: 25592: 25588: 25585: 25583: 25582:Xylopropamine 25580: 25578: 25575: 25573: 25570: 25568: 25565: 25563: 25560: 25558: 25555: 25553: 25550: 25548: 25545: 25543: 25540: 25538: 25535: 25533: 25530: 25528: 25525: 25523: 25520: 25518: 25515: 25513: 25510: 25508: 25505: 25503: 25500: 25498: 25495: 25493: 25490: 25488: 25485: 25483: 25480: 25478: 25472: 25470: 25467: 25465: 25462: 25460: 25457: 25455: 25452: 25449: 25445: 25442: 25440: 25437: 25435: 25432: 25430: 25427: 25425: 25422: 25420: 25417: 25415: 25412: 25410: 25407: 25405: 25402: 25400: 25397: 25395: 25392: 25390: 25387: 25385: 25382: 25380: 25377: 25374: 25370: 25366: 25363: 25361: 25358: 25356: 25353: 25351: 25348: 25346: 25343: 25341: 25338: 25336: 25333: 25331: 25328: 25326: 25323: 25321: 25320:Benzphetamine 25318: 25316: 25313: 25311: 25308: 25305: 25301: 25297: 25294: 25292: 25289: 25287: 25284: 25282: 25279: 25277: 25274: 25272: 25269: 25267: 25264: 25262: 25259: 25257: 25254: 25250: 25247: 25245: 25242: 25240: 25237: 25235: 25232: 25230: 25227: 25225: 25222: 25220: 25217: 25215: 25212: 25210: 25207: 25205: 25202: 25200: 25197: 25195: 25192: 25190: 25187: 25185: 25182: 25180: 25177: 25175: 25172: 25170: 25167: 25165: 25162: 25160: 25157: 25155: 25152: 25150: 25147: 25145: 25142: 25140: 25137: 25135: 25132: 25130: 25127: 25125: 25122: 25120: 25117: 25115: 25112: 25111:Psychedelics: 25109: 25108: 25106: 25104: 25100: 25094: 25091: 25089: 25086: 25082: 25079: 25077: 25074: 25072: 25069: 25066: 25065: 25062: 25059: 25057: 25055: 25051: 25049: 25047: 25043: 25041: 25039: 25035: 25033: 25031: 25027: 25025: 25022: 25020:(amphetamine) 25019: 25016: 25014: 25011: 25009: 25006: 25004: 25001: 25000: 24999: 24998: 24995: 24988: 24985: 24983: 24980: 24978: 24975: 24973: 24970: 24968: 24965: 24963: 24960: 24958: 24955: 24953: 24950: 24948: 24945: 24943: 24942:Isoproscaline 24940: 24938: 24935: 24933: 24930: 24928: 24927:Allylescaline 24925: 24924: 24921: 24918: 24916: 24913: 24911: 24908: 24906: 24903: 24901: 24898: 24896: 24893: 24891: 24888: 24886: 24883: 24881: 24878: 24876: 24873: 24871: 24868: 24866: 24863: 24861: 24858: 24856: 24853: 24851: 24848: 24846: 24843: 24841: 24838: 24836: 24833: 24831: 24828: 24826: 24823: 24821: 24818: 24816: 24813: 24811: 24808: 24806: 24803: 24801: 24798: 24796: 24793: 24791: 24788: 24786: 24783: 24781: 24778: 24776: 24773: 24771: 24768: 24766: 24763: 24761: 24758: 24756: 24753: 24751: 24748: 24746: 24743: 24741: 24738: 24736: 24733: 24731: 24728: 24726: 24723: 24721: 24718: 24716: 24713: 24711: 24708: 24706: 24703: 24701: 24698: 24696: 24693: 24691: 24688: 24686: 24683: 24681: 24678: 24676: 24673: 24671: 24668: 24666: 24663: 24661: 24658: 24656: 24653: 24651: 24648: 24646: 24643: 24641: 24638: 24636: 24633: 24631: 24628: 24626: 24623: 24621: 24618: 24616: 24613: 24611: 24608: 24606: 24603: 24601: 24598: 24597: 24594: 24591: 24589: 24586: 24584: 24581: 24579: 24576: 24574: 24571: 24570:Psychedelics: 24568: 24567: 24565: 24563: 24559: 24555: 24548: 24543: 24541: 24536: 24534: 24529: 24528: 24525: 24515: 24514: 24511: 24505: 24499: 24496: 24494: 24491: 24489: 24486: 24484: 24481: 24479: 24476: 24474: 24471: 24469: 24466: 24464: 24461: 24459: 24456: 24454: 24451: 24449: 24446: 24444: 24441: 24439: 24436: 24434: 24431: 24429: 24426: 24423: 24419: 24416: 24414: 24411: 24409: 24406: 24404: 24401: 24399: 24396: 24394: 24391: 24389: 24386: 24384: 24381: 24379: 24376: 24374: 24371: 24369: 24366: 24364: 24361: 24359: 24356: 24353: 24352: 24349: 24346: 24343: 24342: 24339: 24336: 24334: 24331: 24329: 24326: 24324: 24321: 24319: 24316: 24314: 24311: 24309: 24306: 24304: 24301: 24299: 24296: 24294: 24291: 24289: 24286: 24284: 24281: 24278: 24277: 24274: 24273:Tenocyclidine 24271: 24269: 24266: 24264: 24261: 24259: 24256: 24254: 24251: 24249: 24246: 24244: 24241: 24238: 24237: 24235: 24231: 24225: 24222: 24220: 24217: 24215: 24212: 24207: 24202: 24200: 24197: 24195: 24192: 24190: 24187: 24185: 24182: 24180: 24177: 24175: 24172: 24170: 24167: 24162: 24157: 24152: 24147: 24145: 24142: 24140: 24137: 24135: 24132: 24130: 24127: 24125: 24122: 24120: 24117: 24114: 24113: 24110: 24107: 24105: 24102: 24100: 24097: 24095: 24092: 24090: 24087: 24085: 24082: 24080: 24077: 24075: 24072: 24070: 24067: 24064: 24063: 24060: 24057: 24055: 24052: 24050: 24049:Phencyclidine 24047: 24045: 24042: 24040: 24037: 24035: 24032: 24030: 24027: 24025: 24019: 24017: 24014: 24012: 24009: 24007: 24004: 24002: 23999: 23997: 23994: 23992: 23989: 23987: 23984: 23982: 23979: 23977: 23974: 23972: 23969: 23966: 23965: 23963: 23961: 23954: 23948: 23945: 23943: 23940: 23938: 23935: 23933: 23930: 23928: 23925: 23923: 23920: 23918: 23915: 23913: 23910: 23908: 23905: 23903: 23900: 23898: 23895: 23893: 23890: 23888: 23885: 23883: 23880: 23878: 23875: 23870: 23865: 23860: 23855: 23853: 23847: 23845: 23842: 23840: 23837: 23835: 23832: 23830: 23827: 23825: 23822: 23820: 23819:Amitriptyline 23817: 23815: 23812: 23810: 23807: 23805: 23802: 23800: 23797: 23795: 23792: 23790: 23787: 23785: 23782: 23780: 23777: 23774: 23773: 23770: 23767: 23765: 23762: 23758: 23755: 23752: 23751: 23748: 23745: 23743: 23740: 23738: 23735: 23733: 23730: 23728: 23725: 23723: 23720: 23718: 23715: 23713: 23710: 23708: 23705: 23703: 23700: 23698: 23695: 23693: 23690: 23688: 23685: 23683: 23680: 23678: 23675: 23673: 23670: 23668: 23665: 23663: 23660: 23658: 23655: 23653: 23650: 23648: 23645: 23643: 23640: 23638: 23635: 23633: 23630: 23628: 23625: 23623: 23620: 23617: 23616: 23613: 23610: 23608: 23605: 23603: 23600: 23598: 23595: 23593: 23590: 23588: 23585: 23583: 23580: 23578: 23575: 23573: 23570: 23568: 23565: 23563: 23560: 23558: 23555: 23553: 23550: 23548: 23545: 23543: 23540: 23538: 23535: 23533: 23532:Methoxetamine 23530: 23528: 23525: 23523: 23520: 23518: 23512: 23510: 23507: 23505: 23502: 23500: 23497: 23495: 23492: 23490: 23487: 23485: 23482: 23480: 23477: 23475: 23472: 23470: 23467: 23465: 23462: 23460: 23457: 23455: 23452: 23450: 23447: 23445: 23442: 23440: 23437: 23435: 23432: 23430: 23427: 23424: 23420: 23417: 23414: 23410: 23407: 23405: 23402: 23400: 23397: 23395: 23392: 23390: 23387: 23382: 23377: 23375: 23372: 23370: 23367: 23365: 23362: 23360: 23357: 23355: 23352: 23350: 23347: 23345: 23342: 23340: 23337: 23335: 23332: 23330: 23327: 23325: 23322: 23319: 23318: 23316: 23314: 23307: 23303: 23300: 23293: 23288: 23286: 23281: 23279: 23274: 23273: 23270: 23257: 23256: 23251: 23248: 23247: 23242: 23239: 23238: 23234: 23229: 23226: 23225: 23224:Melatonergics 23220: 23217: 23216: 23215:Dopaminergics 23211: 23208: 23207: 23202: 23199: 23198: 23195: 23190: 23189: 23186: 23171: 23167: 23164: 23161: 23157: 23153: 23150: 23147: 23146: 23143: 23137: 23134: 23131: 23127: 23123: 23119: 23115: 23111: 23107: 23104: 23101: 23097: 23093: 23092:amitriptyline 23089: 23086: 23083: 23079: 23075: 23071: 23067: 23064: 23062: 23059: 23057: 23054: 23052: 23049: 23047: 23044: 23042: 23039: 23037: 23034: 23032: 23029: 23027: 23024: 23022: 23019: 23017: 23014: 23012: 23009: 23007: 23004: 23002: 22999: 22997: 22994: 22992: 22989: 22986: 22982: 22978: 22974: 22970: 22966: 22962: 22958: 22954: 22950: 22949:bromocriptine 22946: 22942: 22938: 22935: 22933: 22930: 22928: 22925: 22923: 22920: 22917: 22913: 22909: 22905: 22901: 22897: 22893: 22889: 22885: 22881: 22880:brexpiprazole 22877: 22873: 22869: 22865: 22862: 22859: 22858: 22855: 22848: 22844: 22840: 22836: 22832: 22829: 22826: 22822: 22819: 22817: 22814: 22812: 22809: 22807: 22804: 22802: 22799: 22797: 22794: 22792: 22789: 22786: 22782: 22779: 22777: 22774: 22772: 22769: 22767: 22764: 22762: 22759: 22756: 22755: 22752: 22749: 22747: 22740: 22729: 22725: 22722: 22719: 22715: 22711: 22710:bromocriptine 22707: 22703: 22700: 22697: 22696: 22693: 22686: 22682: 22678: 22675: 22672: 22671:nortriptyline 22668: 22664: 22660: 22659:amitriptyline 22656: 22653: 22650: 22646: 22642: 22639: 22637: 22634: 22632: 22629: 22627: 22624: 22622: 22619: 22617: 22614: 22612: 22609: 22607: 22604: 22602: 22599: 22597: 22594: 22592: 22589: 22587: 22584: 22582: 22579: 22577: 22574: 22572: 22569: 22567: 22564: 22562: 22559: 22557: 22554: 22552: 22549: 22547: 22544: 22542: 22539: 22537: 22534: 22532: 22529: 22527: 22524: 22522: 22519: 22517: 22514: 22512: 22509: 22506: 22502: 22498: 22494: 22490: 22486: 22482: 22478: 22474: 22471: 22469: 22466: 22463: 22462: 22459: 22453: 22450: 22448: 22445: 22442: 22438: 22434: 22430: 22426: 22422: 22418: 22414: 22410: 22406: 22402: 22398: 22394: 22390: 22387: 22385: 22382: 22380: 22377: 22374: 22370: 22366: 22362: 22358: 22354: 22350: 22346: 22342: 22339: 22336: 22335: 22332: 22329: 22327: 22320: 22309: 22305: 22302: 22299: 22295: 22291: 22288: 22285: 22284: 22281: 22278: 22276: 22273: 22271: 22268: 22266: 22263: 22261: 22258: 22255: 22254: 22251: 22245: 22242: 22239: 22235: 22232: 22230: 22227: 22224: 22220: 22216: 22212: 22209: 22206: 22205: 22202: 22199: 22197: 22190: 22180: 22177: 22175: 22172: 22170: 22167: 22165: 22162: 22160: 22157: 22155: 22152: 22150: 22147: 22145: 22142: 22139: 22138: 22135: 22129: 22126: 22124: 22121: 22119: 22116: 22114: 22111: 22109: 22106: 22104: 22101: 22099: 22096: 22094: 22091: 22089: 22086: 22084: 22081: 22079: 22076: 22074: 22071: 22069: 22066: 22064: 22061: 22059: 22056: 22054: 22051: 22049: 22046: 22044: 22041: 22039: 22036: 22034: 22031: 22028: 22027: 22024: 22021: 22019: 22012: 22001: 21997: 21994: 21992: 21989: 21986: 21985: 21982: 21976: 21973: 21971: 21968: 21966: 21963: 21960: 21956: 21952: 21951:nitrous oxide 21948: 21945: 21942: 21938: 21935: 21933: 21930: 21928: 21925: 21923: 21920: 21917: 21913: 21909: 21905: 21902: 21900: 21899:Tedatioxetine 21897: 21895: 21892: 21890: 21887: 21885: 21882: 21880: 21877: 21875: 21872: 21870: 21867: 21865: 21862: 21860: 21857: 21855: 21852: 21850: 21849:Galanolactone 21847: 21845: 21842: 21840: 21837: 21835: 21832: 21830: 21827: 21825: 21822: 21820: 21817: 21815: 21812: 21810: 21807: 21804: 21800: 21796: 21792: 21789: 21787: 21784: 21782: 21779: 21777: 21774: 21772: 21769: 21766: 21765: 21762: 21756: 21753: 21750: 21746: 21742: 21738: 21734: 21731: 21728: 21724: 21720: 21716: 21713: 21711: 21708: 21706: 21703: 21701: 21698: 21696: 21693: 21690: 21686: 21682: 21678: 21675: 21673: 21670: 21668: 21665: 21662: 21658: 21654: 21650: 21647: 21644: 21643: 21640: 21637: 21635: 21628: 21625: 21622: 21617: 21610: 21595: 21591: 21587: 21584: 21582: 21579: 21576: 21575: 21572: 21566: 21563: 21560: 21556: 21552: 21548: 21544: 21540: 21537: 21534: 21533:nortriptyline 21530: 21529:amitriptyline 21526: 21523: 21521: 21518: 21516: 21513: 21511: 21508: 21505: 21501: 21497: 21493: 21492:esmirtazapine 21489: 21485: 21481: 21478: 21476: 21475:Tedatioxetine 21473: 21471: 21468: 21466: 21463: 21461: 21458: 21456: 21453: 21451: 21448: 21446: 21443: 21441: 21438: 21436: 21433: 21431: 21428: 21426: 21423: 21421: 21418: 21416: 21413: 21411: 21408: 21406: 21403: 21401: 21398: 21396: 21393: 21391: 21388: 21386: 21383: 21381: 21378: 21376: 21373: 21371: 21368: 21366: 21363: 21361: 21358: 21355: 21351: 21347: 21343: 21339: 21335: 21331: 21330:bromocriptine 21327: 21323: 21320: 21318: 21315: 21313: 21310: 21308: 21307:Desmetramadol 21305: 21303: 21300: 21298: 21295: 21293: 21290: 21288: 21285: 21283: 21280: 21277: 21273: 21269: 21265: 21261: 21257: 21253: 21249: 21245: 21241: 21237: 21233: 21229: 21225: 21222: 21220: 21217: 21215: 21212: 21209: 21208: 21205: 21199: 21196: 21194: 21191: 21189: 21186: 21184: 21181: 21178: 21174: 21170: 21166: 21162: 21158: 21154: 21150: 21146: 21142: 21138: 21135: 21133: 21130: 21128: 21125: 21123: 21120: 21118: 21115: 21113: 21110: 21107: 21103: 21099: 21095: 21091: 21087: 21084: 21081: 21077: 21073: 21070: 21068: 21065: 21063: 21060: 21058: 21055: 21053: 21050: 21048: 21045: 21042: 21038: 21034: 21030: 21026: 21023: 21021: 21018: 21016: 21013: 21010: 21006: 21002: 20998: 20994: 20990: 20986: 20982: 20978: 20974: 20970: 20966: 20962: 20958: 20955: 20952: 20948: 20944: 20940: 20936: 20933: 20931: 20928: 20926: 20923: 20921: 20918: 20916: 20913: 20911: 20908: 20905: 20901: 20897: 20893: 20889: 20885: 20881: 20877: 20874: 20871: 20867: 20863: 20859: 20855: 20851: 20848: 20845: 20841: 20837: 20833: 20829: 20825: 20821: 20818: 20815: 20814: 20811: 20808: 20806: 20799: 20788: 20784: 20781: 20778: 20777: 20774: 20768: 20765: 20763: 20760: 20757: 20753: 20750: 20748: 20745: 20742: 20738: 20734: 20730: 20727: 20725: 20722: 20720: 20717: 20715: 20712: 20710: 20707: 20705: 20702: 20700: 20697: 20695: 20692: 20690: 20687: 20685: 20682: 20680: 20677: 20675: 20672: 20670: 20667: 20665: 20662: 20660: 20657: 20655: 20652: 20650: 20647: 20645: 20642: 20640: 20637: 20635: 20632: 20630: 20627: 20625: 20622: 20619: 20615: 20611: 20607: 20603: 20602:bromocriptine 20599: 20595: 20592: 20590: 20587: 20585: 20582: 20579: 20575: 20571: 20567: 20563: 20559: 20555: 20551: 20547: 20543: 20542:brexpiprazole 20539: 20535: 20531: 20527: 20524: 20522: 20519: 20516: 20515: 20512: 20505: 20501: 20497: 20493: 20489: 20485: 20481: 20477: 20473: 20469: 20465: 20461: 20457: 20454: 20452: 20449: 20447: 20444: 20442: 20439: 20436: 20432: 20429: 20426: 20422: 20418: 20414: 20410: 20407: 20405: 20402: 20399: 20395: 20391: 20387: 20383: 20379: 20375: 20371: 20368: 20365: 20361: 20357: 20353: 20349: 20346: 20344: 20341: 20338: 20334: 20330: 20326: 20322: 20318: 20314: 20311: 20309: 20306: 20304: 20301: 20298: 20297: 20294: 20291: 20289: 20282: 20271: 20267: 20263: 20260: 20257: 20256: 20253: 20247: 20244: 20242: 20239: 20237: 20234: 20231: 20227: 20223: 20219: 20215: 20211: 20207: 20203: 20199: 20195: 20191: 20187: 20183: 20179: 20175: 20172: 20169: 20168:amitriptyline 20165: 20162: 20159: 20155: 20151: 20147: 20146:esmirtazapine 20143: 20139: 20135: 20132: 20130: 20127: 20125: 20122: 20120: 20117: 20115: 20112: 20109: 20105: 20104:triazoledione 20101: 20097: 20093: 20089: 20085: 20081: 20078: 20076: 20073: 20071: 20068: 20066: 20063: 20061: 20058: 20056: 20053: 20051: 20048: 20046: 20043: 20041: 20038: 20036: 20033: 20031: 20028: 20026: 20023: 20021: 20018: 20016: 20013: 20011: 20008: 20006: 20005:Naftidrofuryl 20003: 20001: 19998: 19996: 19993: 19991: 19988: 19986: 19983: 19981: 19978: 19976: 19973: 19971: 19968: 19966: 19963: 19961: 19958: 19956: 19953: 19951: 19948: 19946: 19943: 19940: 19936: 19932: 19928: 19924: 19920: 19916: 19912: 19909: 19907: 19904: 19902: 19899: 19897: 19894: 19892: 19889: 19887: 19884: 19882: 19879: 19876: 19872: 19868: 19864: 19860: 19856: 19852: 19848: 19844: 19840: 19836: 19832: 19828: 19824: 19820: 19816: 19812: 19808: 19804: 19800: 19799:brexpiprazole 19796: 19792: 19788: 19784: 19780: 19777: 19775: 19772: 19769: 19765: 19761: 19757: 19753: 19750: 19748: 19745: 19743: 19740: 19738: 19735: 19733: 19730: 19728: 19725: 19722: 19721: 19718: 19711: 19707: 19703: 19699: 19695: 19691: 19687: 19683: 19679: 19675: 19671: 19668: 19666: 19663: 19661: 19658: 19656: 19653: 19650: 19646: 19642: 19638: 19635: 19632: 19628: 19624: 19621: 19619: 19616: 19614: 19611: 19609: 19606: 19604: 19601: 19599: 19596: 19594: 19591: 19589: 19586: 19583: 19579: 19575: 19571: 19567: 19564: 19562: 19559: 19557: 19554: 19552: 19549: 19547: 19544: 19541: 19537: 19533: 19529: 19525: 19521: 19517: 19513: 19509: 19505: 19501: 19497: 19493: 19489: 19488:bromocriptine 19485: 19481: 19477: 19474: 19472: 19469: 19466: 19462: 19458: 19454: 19450: 19447: 19445: 19442: 19440: 19437: 19435: 19432: 19430: 19427: 19425: 19422: 19419: 19415: 19411: 19407: 19403: 19399: 19395: 19391: 19388: 19385: 19381: 19377: 19373: 19369: 19365: 19362: 19360: 19357: 19355: 19352: 19349: 19345: 19341: 19337: 19333: 19329: 19325: 19322: 19319: 19315: 19311: 19307: 19303: 19299: 19295: 19291: 19287: 19283: 19279: 19276: 19275: 19272: 19269: 19267: 19260: 19257: 19255: 19248: 19234: 19231: 19229: 19226: 19223: 19222: 19219: 19212: 19208: 19205: 19202: 19198: 19194: 19190: 19187: 19185: 19182: 19180: 19177: 19175: 19172: 19169: 19166: 19162: 19158: 19157:bromocriptine 19154: 19151: 19149: 19146: 19144: 19141: 19138: 19137: 19134: 19131: 19129: 19122: 19112: 19108: 19104: 19100: 19097: 19094: 19093: 19090: 19084: 19081: 19078: 19077: 19074: 19067: 19063: 19060: 19057: 19053: 19050: 19048: 19045: 19042: 19038: 19035: 19033: 19030: 19027: 19026: 19023: 19020: 19018: 19011: 19000: 18996: 18992: 18988: 18985: 18983: 18980: 18977: 18976: 18973: 18967: 18964: 18962: 18959: 18957: 18954: 18952: 18949: 18947: 18944: 18942: 18939: 18937: 18934: 18932: 18929: 18927: 18924: 18922: 18919: 18917: 18914: 18912: 18909: 18906: 18902: 18899: 18897: 18894: 18892: 18889: 18887: 18884: 18881: 18880: 18877: 18870: 18866: 18862: 18858: 18854: 18850: 18846: 18843: 18840: 18836: 18832: 18828: 18824: 18820: 18816: 18812: 18808: 18804: 18801: 18799: 18796: 18794: 18791: 18789: 18786: 18784: 18781: 18779: 18776: 18774: 18771: 18769: 18766: 18764: 18761: 18758: 18754: 18750: 18746: 18742: 18738: 18737:bromocriptine 18734: 18731: 18729: 18726: 18724: 18721: 18719: 18716: 18713: 18712: 18709: 18706: 18704: 18697: 18686: 18682: 18678: 18674: 18671: 18668: 18667: 18664: 18658: 18655: 18653: 18650: 18648: 18645: 18643: 18640: 18638: 18635: 18633: 18630: 18628: 18625: 18623: 18620: 18617: 18613: 18610: 18608: 18605: 18602: 18598: 18594: 18590: 18586: 18582: 18578: 18574: 18573:Beta blockers 18571: 18569: 18566: 18563: 18562: 18559: 18553: 18550: 18547: 18543: 18539: 18535: 18531: 18528: 18526: 18523: 18520: 18516: 18512: 18508: 18504: 18500: 18497: 18495: 18492: 18490: 18487: 18485: 18482: 18479: 18475: 18471: 18467: 18463: 18459: 18458:bromocriptine 18455: 18452: 18450: 18447: 18445: 18442: 18440: 18437: 18435: 18432: 18430: 18427: 18425: 18422: 18420: 18417: 18414: 18413: 18410: 18407: 18405: 18398: 18387: 18383: 18380: 18378: 18375: 18373: 18370: 18367: 18366: 18363: 18357: 18354: 18352: 18349: 18347: 18344: 18342: 18339: 18337: 18334: 18332: 18329: 18327: 18324: 18322: 18319: 18317: 18314: 18312: 18309: 18307: 18304: 18302: 18299: 18297: 18294: 18292: 18289: 18287: 18284: 18282: 18279: 18277: 18274: 18272: 18269: 18267: 18264: 18262: 18259: 18257: 18254: 18251: 18247: 18244: 18242: 18239: 18237: 18234: 18232: 18229: 18226: 18222: 18218: 18214: 18210: 18206: 18202: 18198: 18194: 18193:cyanopindolol 18190: 18186: 18182: 18181:Beta blockers 18179: 18177: 18174: 18171: 18167: 18163: 18159: 18156: 18153: 18152: 18149: 18143: 18140: 18138: 18135: 18133: 18130: 18128: 18125: 18123: 18120: 18118: 18115: 18112: 18108: 18104: 18100: 18096: 18092: 18088: 18084: 18080: 18076: 18073: 18071: 18068: 18066: 18063: 18061: 18058: 18056: 18053: 18051: 18048: 18046: 18043: 18041: 18038: 18036: 18033: 18031: 18028: 18026: 18023: 18021: 18018: 18016: 18013: 18011: 18008: 18006: 18003: 18001: 17998: 17996: 17993: 17991: 17988: 17986: 17983: 17981: 17978: 17976: 17973: 17971: 17968: 17966: 17963: 17961: 17958: 17956: 17953: 17951: 17948: 17946: 17943: 17941: 17938: 17936: 17933: 17931: 17928: 17926: 17923: 17921: 17918: 17916: 17913: 17910: 17906: 17902: 17898: 17894: 17890: 17886: 17882: 17878: 17877:bromocriptine 17874: 17871: 17869: 17866: 17864: 17861: 17859: 17856: 17854: 17851: 17849: 17846: 17844: 17841: 17839: 17836: 17834: 17831: 17829: 17826: 17823: 17819: 17815: 17811: 17807: 17803: 17800: 17797: 17793: 17789: 17785: 17781: 17777: 17776:brexpiprazole 17773: 17769: 17765: 17762: 17759: 17755: 17751: 17750:triazoledione 17747: 17743: 17739: 17735: 17731: 17728: 17726: 17723: 17721: 17718: 17716: 17713: 17710: 17709: 17706: 17703: 17701: 17694: 17691: 17689: 17682: 17678: 17675: 17668: 17663: 17661: 17656: 17654: 17649: 17648: 17645: 17633: 17630: 17628: 17625: 17623: 17620: 17617: 17616: 17613: 17607: 17604: 17602: 17599: 17597: 17594: 17592: 17589: 17587: 17584: 17582: 17579: 17577: 17574: 17572: 17569: 17567: 17564: 17561: 17557: 17554: 17552: 17549: 17547: 17544: 17543: 17541: 17537: 17531: 17527: 17517: 17514: 17512: 17509: 17507: 17504: 17502: 17499: 17497: 17494: 17492: 17489: 17487: 17484: 17482: 17479: 17477: 17474: 17472: 17469: 17467: 17464: 17462: 17459: 17457: 17454: 17452: 17449: 17447: 17444: 17442: 17439: 17437: 17434: 17432: 17429: 17427: 17424: 17422: 17419: 17417: 17416:Phencyclidine 17414: 17412: 17409: 17407: 17404: 17402: 17399: 17397: 17394: 17392: 17389: 17387: 17386:Nitrous oxide 17384: 17382: 17379: 17377: 17374: 17372: 17369: 17367: 17364: 17362: 17359: 17357: 17354: 17352: 17349: 17347: 17344: 17342: 17339: 17337: 17334: 17332: 17329: 17327: 17326:Levomethadone 17324: 17322: 17319: 17317: 17314: 17312: 17309: 17307: 17304: 17302: 17299: 17297: 17294: 17292: 17289: 17287: 17284: 17282: 17279: 17277: 17274: 17272: 17271:Hexafluronium 17269: 17267: 17264: 17262: 17259: 17257: 17254: 17252: 17249: 17247: 17244: 17242: 17239: 17237: 17234: 17232: 17229: 17227: 17224: 17222: 17219: 17217: 17214: 17212: 17209: 17207: 17204: 17202: 17199: 17197: 17194: 17192: 17189: 17187: 17184: 17182: 17179: 17177: 17174: 17172: 17169: 17167: 17164: 17162: 17161:Decamethonium 17159: 17157: 17154: 17152: 17149: 17147: 17144: 17142: 17139: 17137: 17134: 17132: 17131:Cisatracurium 17129: 17127: 17124: 17122: 17119: 17117: 17114: 17112: 17109: 17107: 17104: 17101: 17097: 17093: 17092:Bungarotoxins 17090: 17088: 17085: 17082: 17078: 17077:pentobarbital 17074: 17071: 17069: 17066: 17064: 17061: 17059: 17056: 17054: 17051: 17049: 17046: 17044: 17041: 17039: 17036: 17033: 17029: 17025: 17021: 17020:α-Neurotoxins 17018: 17016: 17013: 17011: 17008: 17007: 17005: 16999: 16992: 16988: 16982: 16979: 16977: 16974: 16972: 16969: 16967: 16964: 16962: 16959: 16957: 16954: 16952: 16949: 16947: 16944: 16942: 16939: 16937: 16934: 16932: 16929: 16927: 16924: 16922: 16919: 16917: 16914: 16912: 16909: 16907: 16904: 16902: 16899: 16897: 16894: 16892: 16889: 16887: 16884: 16882: 16879: 16877: 16874: 16872: 16869: 16867: 16864: 16862: 16859: 16857: 16854: 16852: 16849: 16847: 16844: 16842: 16839: 16837: 16834: 16832: 16829: 16827: 16824: 16821: 16817: 16814: 16812: 16809: 16807: 16804: 16802: 16799: 16797: 16794: 16792: 16789: 16787: 16784: 16782: 16779: 16777: 16774: 16772: 16769: 16767: 16764: 16762: 16759: 16757: 16754: 16752: 16749: 16747: 16744: 16742: 16739: 16737: 16734: 16732: 16729: 16727: 16724: 16722: 16721:Decamethonium 16719: 16717: 16714: 16712: 16709: 16707: 16704: 16702: 16699: 16697: 16694: 16692: 16689: 16687: 16684: 16682: 16679: 16677: 16674: 16672: 16669: 16667: 16664: 16662: 16659: 16657: 16656:Acetylcholine 16654: 16652: 16649: 16647: 16644: 16642: 16639: 16637: 16634: 16632: 16629: 16627: 16624: 16622: 16619: 16617: 16614: 16612: 16609: 16607: 16604: 16603: 16601: 16595: 16588: 16584: 16581: 16576: 16570: 16566: 16563: 16556: 16551: 16549: 16544: 16542: 16537: 16536: 16533: 16522: 16521: 16517: 16513: 16512:Serotonergics 16509: 16508:Dopaminergics 16505: 16501: 16497: 16494: 16487: 16481: 16478: 16474: 16471: 16469: 16466: 16465:Agonist-like: 16463: 16460: 16459: 16456: 16453: 16450: 16449: 16447: 16443: 16437: 16434: 16432: 16429: 16427: 16426:Tetrabenazine 16424: 16422: 16419: 16417: 16414: 16412: 16409: 16407: 16404: 16402: 16399: 16397: 16394: 16392: 16389: 16387: 16384: 16382: 16379: 16377: 16374: 16372: 16369: 16367: 16364: 16362: 16359: 16357: 16354: 16352: 16349: 16346: 16342: 16338: 16334: 16331: 16329: 16326: 16325: 16323: 16318: 16312: 16302: 16299: 16296: 16292: 16288: 16284: 16280: 16276: 16272: 16269: 16267: 16264: 16262: 16259: 16257: 16254: 16252: 16249: 16247: 16244: 16242: 16239: 16237: 16234: 16232: 16229: 16227: 16224: 16222: 16219: 16217: 16214: 16211: 16210:phencyclidine 16207: 16206:methoxetamine 16203: 16199: 16195: 16191: 16188: 16185: 16181: 16177: 16174: 16171: 16167: 16163: 16159: 16155: 16151: 16147: 16143: 16140: 16138: 16135: 16133: 16130: 16127: 16126: 16123: 16117: 16116:Protriptyline 16114: 16112: 16109: 16107: 16106:Nortriptyline 16104: 16102: 16099: 16097: 16094: 16092: 16089: 16087: 16084: 16082: 16079: 16077: 16074: 16072: 16069: 16067: 16064: 16062: 16061:Amitriptyline 16059: 16056: 16055: 16052: 16045: 16041: 16038: 16036: 16033: 16031: 16028: 16026: 16025:Tedatioxetine 16023: 16021: 16018: 16016: 16013: 16011: 16008: 16006: 16003: 16001: 15998: 15996: 15993: 15991: 15988: 15986: 15983: 15981: 15978: 15976: 15973: 15971: 15968: 15966: 15963: 15961: 15958: 15956: 15953: 15951: 15948: 15946: 15943: 15941: 15938: 15936: 15933: 15931: 15928: 15926: 15923: 15921: 15918: 15916: 15913: 15911: 15908: 15906: 15903: 15901: 15898: 15896: 15893: 15891: 15888: 15886: 15885:Centanafadine 15883: 15881: 15878: 15876: 15873: 15871: 15868: 15866: 15863: 15861: 15858: 15855: 15854: 15851: 15845: 15842: 15840: 15837: 15835: 15832: 15830: 15829:N-Methyl-PPPA 15827: 15825: 15822: 15820: 15817: 15815: 15812: 15810: 15807: 15805: 15802: 15800: 15797: 15795: 15792: 15790: 15787: 15785: 15782: 15779: 15778: 15775: 15769: 15766: 15764: 15761: 15759: 15756: 15754: 15751: 15749: 15746: 15744: 15741: 15739: 15736: 15734: 15731: 15729: 15726: 15724: 15721: 15718: 15717: 15714: 15711: 15709: 15706: 15704: 15701: 15699: 15696: 15694: 15691: 15689: 15686: 15684: 15681: 15679: 15676: 15674: 15671: 15669: 15668:Norfluoxetine 15666: 15664: 15661: 15659: 15656: 15654: 15651: 15649: 15646: 15644: 15641: 15639: 15636: 15634: 15631: 15629: 15626: 15624: 15621: 15619: 15616: 15614: 15611: 15609: 15608:Centpropazine 15606: 15604: 15601: 15599: 15596: 15593: 15592: 15589: 15586: 15579: 15568: 15562: 15551: 15547: 15543: 15539: 15535: 15531: 15530:desmetramadol 15527: 15524: 15522: 15519: 15517: 15514: 15512: 15511: 15510:Ginkgo biloba 15507: 15505: 15502: 15500: 15497: 15494: 15493:phencyclidine 15490: 15486: 15483: 15480: 15476: 15472: 15469: 15466: 15462: 15458: 15454: 15450: 15447: 15444: 15443: 15440: 15434: 15431: 15429: 15426: 15424: 15421: 15419: 15416: 15414: 15411: 15408: 15407: 15404: 15398: 15395: 15393: 15392:Protriptyline 15390: 15388: 15387:Nortriptyline 15385: 15383: 15380: 15378: 15375: 15373: 15370: 15368: 15365: 15363: 15360: 15358: 15355: 15353: 15350: 15348: 15345: 15343: 15340: 15338: 15337:Amitriptyline 15335: 15332: 15331: 15328: 15321: 15317: 15314: 15312: 15309: 15307: 15304: 15302: 15301:Tedatioxetine 15299: 15297: 15294: 15292: 15289: 15287: 15284: 15282: 15279: 15277: 15274: 15272: 15269: 15267: 15264: 15262: 15259: 15257: 15254: 15252: 15249: 15247: 15244: 15242: 15239: 15237: 15234: 15232: 15229: 15227: 15224: 15222: 15219: 15217: 15214: 15212: 15209: 15207: 15204: 15202: 15199: 15197: 15194: 15192: 15189: 15187: 15184: 15182: 15179: 15177: 15174: 15172: 15169: 15167: 15164: 15162: 15161:Centanafadine 15159: 15157: 15154: 15152: 15149: 15147: 15144: 15142: 15139: 15137: 15134: 15131: 15130: 15127: 15121: 15118: 15116: 15113: 15111: 15108: 15106: 15103: 15101: 15100:N-Methyl-PPPA 15098: 15096: 15093: 15091: 15088: 15086: 15083: 15081: 15078: 15076: 15073: 15071: 15068: 15066: 15063: 15061: 15058: 15055: 15054: 15051: 15045: 15042: 15040: 15037: 15035: 15032: 15030: 15027: 15025: 15022: 15020: 15017: 15015: 15012: 15010: 15007: 15005: 15002: 15000: 14997: 14995: 14992: 14990: 14987: 14985: 14982: 14980: 14977: 14975: 14972: 14969: 14968: 14965: 14959: 14956: 14954: 14951: 14949: 14946: 14944: 14941: 14939: 14936: 14934: 14931: 14929: 14926: 14924: 14921: 14919: 14916: 14914: 14911: 14909: 14906: 14904: 14901: 14899: 14896: 14894: 14891: 14889: 14886: 14883: 14882: 14879: 14876: 14869: 14858: 14852: 14842: 14839: 14837: 14834: 14832: 14829: 14827: 14826:Tedatioxetine 14824: 14822: 14819: 14817: 14814: 14812: 14809: 14807: 14804: 14802: 14799: 14797: 14794: 14792: 14789: 14787: 14784: 14782: 14779: 14777: 14774: 14772: 14769: 14767: 14764: 14762: 14759: 14757: 14754: 14752: 14749: 14747: 14744: 14742: 14739: 14737: 14734: 14732: 14729: 14727: 14724: 14722: 14719: 14717: 14714: 14712: 14709: 14707: 14704: 14702: 14699: 14697: 14694: 14692: 14689: 14687: 14684: 14682: 14679: 14677: 14674: 14672: 14669: 14667: 14664: 14662: 14659: 14657: 14654: 14652: 14649: 14647: 14644: 14642: 14639: 14637: 14634: 14632: 14629: 14627: 14624: 14622: 14619: 14617: 14614: 14612: 14609: 14607: 14604: 14602: 14599: 14597: 14594: 14592: 14591: 14587: 14585: 14582: 14580: 14577: 14575: 14572: 14570: 14567: 14565: 14562: 14560: 14557: 14555: 14552: 14550: 14547: 14545: 14542: 14539: 14538: 14535: 14529: 14526: 14524: 14521: 14519: 14516: 14514: 14511: 14509: 14506: 14504: 14501: 14499: 14496: 14494: 14491: 14489: 14486: 14484: 14481: 14479: 14476: 14474: 14471: 14469: 14466: 14464: 14461: 14459: 14456: 14454: 14451: 14449: 14448:Ioflupane (I) 14446: 14444: 14441: 14439: 14436: 14434: 14431: 14429: 14426: 14424: 14421: 14419: 14416: 14414: 14411: 14409: 14406: 14404: 14401: 14399: 14396: 14393: 14392: 14389: 14383: 14380: 14378: 14375: 14373: 14370: 14368: 14365: 14363: 14360: 14359:Pyrrolidines: 14357: 14356: 14353: 14347: 14346:Tenocyclidine 14344: 14342: 14339: 14337: 14334: 14332: 14331:Phencyclidine 14329: 14327: 14324: 14322: 14319: 14317: 14314: 14312: 14309: 14307: 14304: 14302: 14299: 14297: 14294: 14292: 14289: 14287: 14284: 14281: 14280: 14277: 14271: 14268: 14266: 14263: 14261: 14258: 14256: 14253: 14251: 14248: 14246: 14243: 14241: 14238: 14236: 14233: 14230: 14229: 14226: 14223: 14216: 14205: 14199: 14195: 14188: 14183: 14181: 14176: 14174: 14169: 14168: 14165: 14153: 14152: 14149: 14145: 14144: 14141: 14134: 14133: 14128: 14125: 14123: 14120: 14117: 14116: 14111: 14108: 14105: 14101: 14097: 14093: 14090: 14088: 14085: 14083: 14080: 14078: 14075: 14073: 14070: 14068: 14065: 14063: 14060: 14058: 14055: 14053: 14050: 14048: 14045: 14043: 14040: 14038: 14035: 14033: 14030: 14028: 14025: 14022: 14018: 14014: 14010: 14007: 14006: 14004: 14000: 13993: 13990:Mixed (e.g., 13989: 13986: 13982: 13978: 13975: 13972: 13968: 13964: 13960: 13956: 13953: 13950: 13946: 13942: 13938: 13935: 13934: 13932: 13930: 13926: 13920: 13917: 13915: 13912: 13910: 13907: 13905: 13902: 13900: 13897: 13895: 13892: 13890: 13887: 13885: 13882: 13880: 13877: 13875: 13872: 13870: 13867: 13865: 13864:Acetildenafil 13862: 13861: 13859: 13857: 13853: 13847: 13844: 13842: 13839: 13837: 13836:Bremelanotide 13834: 13833: 13831: 13829: 13825: 13819: 13816: 13814: 13811: 13809: 13806: 13804: 13801: 13799: 13796: 13794: 13791: 13789: 13786: 13784: 13781: 13779: 13776: 13774: 13771: 13770: 13768: 13766: 13762: 13758: 13755: 13748: 13743: 13741: 13736: 13734: 13729: 13728: 13725: 13709: 13707: 13704: 13703: 13701: 13698: 13695: 13692: 13690: 13687: 13686: 13682: 13676: 13673: 13671: 13668: 13666: 13663: 13661: 13658: 13656: 13655:Setmelanotide 13653: 13651: 13648: 13646: 13643: 13641: 13638: 13636: 13633: 13631: 13628: 13626: 13623: 13622: 13620: 13616: 13610: 13607: 13606: 13604: 13602: 13598: 13592: 13589: 13587: 13584: 13582: 13579: 13577: 13574: 13572: 13569: 13568: 13566: 13562: 13556: 13553: 13551: 13548: 13547: 13545: 13543: 13537: 13530: 13526: 13523: 13522: 13520: 13518: 13514: 13507: 13504: 13501: 13500:+cagrilintide 13497: 13494: 13492: 13489: 13487: 13486:Oxyntomodulin 13484: 13482: 13479: 13477: 13474: 13471: 13468: 13466: 13463: 13461: 13458: 13456: 13453: 13451: 13448: 13446: 13443: 13442: 13440: 13438: 13434: 13430: 13426: 13422: 13416: 13413: 13411: 13408: 13406: 13403: 13401: 13398: 13396: 13393: 13391: 13388: 13386: 13383: 13382: 13380: 13378: 13372: 13362: 13359: 13357: 13354: 13352: 13349: 13347: 13344: 13342: 13339: 13337: 13334: 13332: 13331:Phenmetrazine 13329: 13327: 13324: 13322: 13319: 13317: 13314: 13312: 13309: 13307: 13304: 13301: 13297: 13294: 13292: 13289: 13287: 13284: 13282: 13279: 13277: 13274: 13271: 13267: 13264: 13262: 13259: 13257: 13254: 13252: 13249: 13248: 13246: 13242: 13235: 13231: 13228: 13226: 13223: 13221: 13218: 13216: 13213: 13211: 13208: 13206: 13203: 13201: 13198: 13196: 13193: 13192: 13190: 13188: 13184: 13178: 13175: 13173: 13172:Xylopropamine 13170: 13167: 13163: 13160: 13158: 13155: 13153: 13150: 13148: 13145: 13143: 13140: 13138: 13135: 13133: 13130: 13128: 13125: 13123: 13120: 13118: 13115: 13113: 13110: 13108: 13105: 13103: 13100: 13098: 13095: 13093: 13090: 13088: 13085: 13083: 13080: 13078: 13075: 13073: 13070: 13068: 13065: 13063: 13060: 13058: 13055: 13053: 13050: 13048: 13047:Benzphetamine 13045: 13043: 13040: 13038: 13035: 13033: 13030: 13028: 13025: 13023: 13020: 13018: 13015: 13014: 13012: 13010: 13005: 13001: 12998: 12996: 12992: 12987: 12983: 12979: 12972: 12967: 12965: 12960: 12958: 12953: 12952: 12949: 12936: 12935:Phenobarbital 12932: 12931: 12927: 12924: 12921: 12919: 12916: 12914: 12911: 12909: 12905: 12904: 12900: 12897: 12893: 12889: 12883: 12882: 12880: 12878: 12874: 12867: 12864: 12862: 12858: 12857: 12853: 12849: 12846: 12844: 12841: 12839: 12836: 12834: 12831: 12829: 12826: 12824: 12821: 12818: 12814: 12813:Buprenorphine 12811: 12810: 12809: 12808: 12804: 12802: 12799: 12796: 12793: 12791: 12787: 12783: 12777: 12776: 12774: 12772: 12768: 12762: 12759: 12757: 12754: 12751: 12747: 12743: 12737: 12735: 12732: 12728: 12725: 12723: 12720: 12719: 12718: 12717: 12713: 12709: 12708:Nitrous oxide 12706: 12705: 12704: 12703: 12699: 12695: 12692: 12690: 12687: 12685: 12682: 12680: 12677: 12676: 12675: 12674: 12667: 12666: 12664: 12662: 12658: 12651: 12647: 12643: 12637: 12635: 12632: 12630: 12627: 12625: 12622: 12620: 12617: 12615: 12612: 12611: 12609: 12607: 12603: 12598: 12594: 12591:Treatment of 12586: 12581: 12579: 12574: 12572: 12567: 12566: 12563: 12547: 12545: 12542: 12541: 12539: 12536: 12533: 12530: 12528: 12525: 12524: 12520: 12510: 12507: 12505: 12502: 12500: 12493: 12491: 12489: 12485: 12482: 12478: 12474: 12473:neurosteroids 12471: 12468: 12466: 12459: 12458: 12455: 12451:Miscellaneous 12448: 12444: 12429: 12428:levothyroxine 12421: 12417: 12414: 12411: 12407: 12403: 12400: 12398: 12395: 12392: 12388: 12384: 12380: 12376: 12375:brexpiprazole 12372: 12368: 12365: 12364: 12361: 12357: 12352: 12348: 12334: 12331: 12330:Irreversible: 12328: 12327: 12325: 12319: 12310: 12304: 12301: 12299: 12296: 12294: 12291: 12289: 12286: 12284: 12281: 12279: 12276: 12274: 12271: 12268: 12267: 12265: 12259: 12250: 12244: 12241: 12238: 12237: 12234: 12231: 12228: 12227: 12224: 12221: 12219: 12216: 12214: 12211: 12209: 12206: 12204: 12201: 12199: 12196: 12194: 12191: 12189: 12186: 12184: 12181: 12179: 12176: 12174: 12171: 12169: 12166: 12164: 12163:Isocarboxazid 12161: 12159: 12156: 12154: 12151: 12149: 12146: 12145:Irreversible: 12143: 12142: 12140: 12138:Non-selective 12136: 12132: 12128: 12123: 12119: 12105: 12102: 12101: 12099: 12095: 12089: 12086: 12084: 12081: 12079: 12076: 12074: 12071: 12070: 12068: 12063: 12057: 12051: 12048: 12046: 12043: 12041: 12038: 12036: 12035:Protriptyline 12033: 12031: 12028: 12026: 12023: 12021: 12018: 12016: 12013: 12011: 12010:Nortriptyline 12008: 12006: 12005:Nitroxazepine 12003: 12001: 11998: 11996: 11993: 11991: 11988: 11986: 11983: 11981: 11978: 11976: 11973: 11971: 11968: 11966: 11963: 11961: 11958: 11956: 11953: 11951: 11948: 11946: 11945:Demexiptiline 11943: 11941: 11938: 11936: 11933: 11931: 11928: 11926: 11923: 11921: 11920:Amitriptyline 11918: 11916: 11913: 11912: 11910: 11905: 11899: 11895: 11891: 11887: 11882: 11878: 11864: 11861: 11859: 11856: 11854: 11851: 11849: 11846: 11844: 11841: 11839: 11836: 11834: 11831: 11829: 11826: 11824: 11821: 11819: 11816: 11814: 11811: 11809: 11806: 11804: 11801: 11799: 11796: 11794: 11791: 11789: 11786: 11785: 11783: 11779: 11773: 11770: 11768: 11765: 11764: 11762: 11757: 11751: 11745: 11742: 11740: 11737: 11735: 11732: 11731: 11729: 11724: 11718: 11712: 11709: 11707: 11704: 11702: 11699: 11698: 11696: 11691: 11685: 11679: 11676: 11674: 11671: 11669: 11666: 11665: 11663: 11658: 11652: 11646: 11643: 11641: 11638: 11636: 11633: 11632: 11630: 11625: 11619: 11613: 11610: 11608: 11605: 11603: 11600: 11598: 11595: 11593: 11590: 11588: 11585: 11584: 11582: 11577: 11571: 11565: 11562: 11560: 11557: 11555: 11552: 11550: 11547: 11545: 11542: 11540: 11537: 11535: 11532: 11530: 11527: 11526: 11524: 11519: 11513: 11509: 11505: 11501: 11495: 11491: 11486: 11482: 11475: 11470: 11468: 11463: 11461: 11456: 11455: 11452: 11441: 11437: 11432: 11427: 11423: 11419: 11415: 11408: 11400: 11396: 11392: 11388: 11384: 11380: 11373: 11365: 11361: 11357: 11353: 11349: 11345: 11338: 11330: 11324: 11320: 11313: 11297: 11293: 11289: 11283: 11275: 11269: 11265: 11258: 11251: 11239: 11235: 11231: 11225: 11217: 11213: 11209: 11205: 11201: 11197: 11193: 11189: 11182: 11174: 11170: 11166: 11162: 11158: 11154: 11147: 11139: 11135: 11131: 11127: 11123: 11119: 11115: 11111: 11104: 11097: 11093: 11090: 11085: 11077: 11073: 11068: 11063: 11059: 11055: 11048: 11040: 11036: 11032: 11028: 11024: 11020: 11016: 11012: 11005: 11003: 10986: 10982: 10978: 10971: 10955: 10951: 10947: 10941: 10922: 10918: 10911: 10904: 10888: 10884: 10880: 10873: 10857: 10853: 10849: 10842: 10826: 10822: 10818: 10814: 10808: 10789: 10785: 10781: 10774: 10768: 10752: 10748: 10744: 10738: 10722: 10718: 10716: 10710: 10704: 10688: 10684: 10680: 10673: 10666: 10665:public domain 10647: 10643: 10639: 10633: 10631: 10629: 10612: 10608: 10607: 10602: 10596: 10580: 10576: 10575: 10570: 10563: 10547: 10543: 10537: 10521: 10517: 10511: 10492: 10488: 10486: 10477: 10471: 10455: 10451: 10449: 10443: 10437: 10421: 10417: 10415: 10409: 10403: 10387: 10383: 10379: 10375: 10368: 10366: 10349: 10345: 10339: 10323: 10319: 10313: 10305: 10301: 10297: 10293: 10289: 10285: 10278: 10270: 10266: 10261: 10256: 10252: 10248: 10244: 10240: 10236: 10229: 10221: 10217: 10212: 10207: 10203: 10199: 10195: 10188: 10180: 10176: 10172: 10168: 10163: 10158: 10154: 10150: 10146: 10139: 10124: 10118: 10114: 10113: 10105: 10089: 10085: 10079: 10077: 10061: 10057: 10051: 10049: 10040: 10036: 10032: 10028: 10024: 10020: 10013: 10005: 10001: 9997: 9993: 9989: 9985: 9978: 9970: 9966: 9962: 9958: 9954: 9950: 9943: 9941: 9932: 9928: 9924: 9920: 9916: 9912: 9905: 9903: 9894: 9890: 9886: 9880: 9876: 9872: 9868: 9861: 9859: 9857: 9855: 9845: 9837: 9833: 9829: 9825: 9818: 9810: 9806: 9802: 9798: 9794: 9790: 9782: 9774: 9768: 9764: 9763: 9755: 9739: 9735: 9731: 9727: 9723: 9719: 9715: 9711: 9704: 9702: 9693: 9689: 9685: 9681: 9677: 9673: 9669: 9665: 9658: 9656: 9647: 9643: 9639: 9635: 9632:(6): 2502–5. 9631: 9627: 9619: 9611: 9607: 9602: 9597: 9593: 9589: 9585: 9581: 9577: 9570: 9562: 9558: 9554: 9550: 9546: 9542: 9538: 9534: 9527: 9519: 9515: 9511: 9507: 9503: 9499: 9495: 9491: 9484: 9476: 9472: 9467: 9462: 9458: 9454: 9453:Res Pharm Sci 9450: 9443: 9435: 9431: 9427: 9423: 9418: 9413: 9409: 9405: 9401: 9394: 9392: 9384: 9379: 9375: 9371: 9367: 9363: 9359: 9358:CNS Spectrums 9352: 9344: 9340: 9336: 9332: 9328: 9324: 9317: 9309: 9305: 9300: 9295: 9290: 9285: 9281: 9277: 9273: 9266: 9258: 9254: 9250: 9246: 9242: 9238: 9230: 9223: 9218: 9214: 9210: 9206: 9202: 9198: 9191: 9189: 9180: 9176: 9172: 9168: 9164: 9160: 9153: 9151: 9149: 9140: 9136: 9131: 9126: 9122: 9118: 9115:: 1114–1136. 9114: 9110: 9106: 9099: 9097: 9095: 9086: 9082: 9078: 9074: 9070: 9066: 9062: 9058: 9051: 9043: 9039: 9034: 9029: 9025: 9021: 9017: 9013: 9009: 9002: 8994: 8990: 8986: 8982: 8978: 8974: 8967: 8965: 8963: 8961: 8951: 8943: 8939: 8935: 8931: 8927: 8923: 8922:Mol Pharmacol 8915: 8907: 8903: 8899: 8895: 8891: 8887: 8880: 8872: 8868: 8864: 8860: 8856: 8852: 8845: 8837: 8833: 8829: 8825: 8821: 8817: 8810: 8802: 8798: 8794: 8790: 8786: 8782: 8775: 8767: 8763: 8760:(1): 94–102. 8759: 8755: 8748: 8733: 8729: 8723: 8721: 8705: 8701: 8694: 8692: 8675: 8671: 8664:, Driscol J. 8663: 8657: 8655: 8646: 8642: 8637: 8632: 8628: 8624: 8620: 8616: 8612: 8605: 8597: 8593: 8588: 8583: 8579: 8575: 8571: 8567: 8563: 8556: 8548: 8544: 8540: 8536: 8532: 8528: 8524: 8520: 8512: 8510: 8501: 8497: 8493: 8489: 8485: 8481: 8474: 8466: 8462: 8458: 8454: 8450: 8446: 8442: 8438: 8431: 8429: 8427: 8418: 8414: 8409: 8404: 8400: 8396: 8392: 8388: 8384: 8377: 8375: 8373: 8371: 8369: 8360: 8356: 8352: 8348: 8344: 8340: 8336: 8332: 8325: 8317: 8313: 8308: 8303: 8299: 8295: 8291: 8287: 8283: 8276: 8268: 8264: 8260: 8256: 8252: 8248: 8241: 8233: 8229: 8225: 8221: 8217: 8213: 8206: 8198: 8194: 8190: 8186: 8181: 8176: 8172: 8168: 8164: 8160: 8152: 8150: 8141: 8137: 8133: 8129: 8124: 8119: 8115: 8111: 8107: 8100: 8092: 8088: 8083: 8078: 8074: 8070: 8066: 8059: 8040: 8036: 8029: 8023: 8021: 8019: 8010: 8006: 8002: 7998: 7994: 7990: 7983: 7975: 7971: 7967: 7963: 7959: 7955: 7948: 7946: 7944: 7942: 7940: 7938: 7929: 7925: 7920: 7915: 7911: 7907: 7903: 7899: 7895: 7888: 7880: 7874: 7870: 7863: 7855: 7851: 7846: 7841: 7837: 7833: 7829: 7825: 7821: 7814: 7798: 7794: 7790: 7783: 7781: 7772: 7768: 7763: 7758: 7754: 7750: 7746: 7742: 7738: 7731: 7723: 7719: 7715: 7711: 7704: 7696: 7692: 7687: 7682: 7678: 7674: 7670: 7666: 7662: 7655: 7647: 7643: 7639: 7635: 7631: 7627: 7624:(2): 91–110. 7623: 7619: 7612: 7604: 7600: 7596: 7592: 7588: 7584: 7576: 7568: 7564: 7559: 7554: 7550: 7546: 7542: 7538: 7534: 7527: 7519: 7515: 7511: 7507: 7503: 7499: 7495: 7491: 7484: 7468: 7464: 7460: 7456: 7452: 7448: 7444: 7440: 7436: 7432: 7425: 7417: 7413: 7409: 7405: 7401: 7397: 7393: 7389: 7381: 7365: 7361: 7357: 7351: 7335: 7331: 7325: 7323: 7321: 7319: 7317: 7315: 7306: 7302: 7298: 7294: 7290: 7286: 7279: 7271: 7267: 7263: 7259: 7255: 7251: 7244: 7236: 7232: 7228: 7224: 7221:(4): 377–88. 7220: 7216: 7209: 7202: 7197: 7193: 7189: 7188: 7180: 7178: 7176: 7167: 7163: 7158: 7153: 7149: 7145: 7141: 7137: 7133: 7126: 7118: 7114: 7109: 7104: 7099: 7094: 7090: 7086: 7082: 7075: 7067: 7063: 7058: 7053: 7049: 7045: 7041: 7034: 7026: 7022: 7017: 7012: 7007: 7002: 6998: 6994: 6990: 6983: 6975: 6971: 6967: 6963: 6959: 6955: 6947: 6939: 6935: 6931: 6927: 6923: 6919: 6912: 6904: 6900: 6895: 6890: 6886: 6882: 6878: 6874: 6870: 6863: 6847: 6843: 6839: 6833: 6817: 6813: 6811: 6805: 6799: 6791: 6787: 6782: 6777: 6773: 6769: 6765: 6758: 6756: 6747: 6743: 6739: 6735: 6730: 6725: 6721: 6717: 6713: 6709: 6705: 6698: 6690: 6686: 6681: 6676: 6672: 6668: 6664: 6657: 6649: 6645: 6640: 6635: 6631: 6627: 6623: 6619: 6615: 6608: 6600: 6596: 6591: 6586: 6582: 6578: 6574: 6570: 6566: 6559: 6551: 6547: 6542: 6537: 6533: 6529: 6525: 6521: 6517: 6510: 6502: 6498: 6494: 6490: 6486: 6482: 6478: 6474: 6467: 6459: 6455: 6450: 6445: 6441: 6437: 6433: 6429: 6425: 6418: 6416: 6407: 6403: 6399: 6395: 6391: 6387: 6380: 6372: 6368: 6363: 6358: 6354: 6350: 6346: 6342: 6338: 6331: 6323: 6319: 6314: 6309: 6304: 6299: 6295: 6291: 6287: 6283: 6279: 6272: 6264: 6260: 6255: 6250: 6246: 6242: 6238: 6234: 6230: 6223: 6215: 6211: 6206: 6201: 6197: 6193: 6189: 6185: 6181: 6174: 6166: 6162: 6157: 6152: 6148: 6144: 6140: 6133: 6125: 6121: 6116: 6111: 6107: 6103: 6099: 6092: 6084: 6080: 6075: 6070: 6066: 6062: 6058: 6054: 6050: 6043: 6035: 6031: 6026: 6021: 6017: 6013: 6009: 6005: 6001: 5994: 5986: 5982: 5978: 5974: 5970: 5966: 5962: 5958: 5951: 5949: 5947: 5938: 5934: 5929: 5924: 5919: 5914: 5910: 5906: 5902: 5895: 5887: 5883: 5878: 5873: 5869: 5865: 5861: 5857: 5853: 5846: 5844: 5835: 5831: 5826: 5821: 5816: 5811: 5807: 5803: 5799: 5792: 5784: 5780: 5775: 5770: 5765: 5760: 5756: 5752: 5748: 5741: 5733: 5729: 5725: 5721: 5716: 5711: 5707: 5703: 5699: 5692: 5684: 5680: 5676: 5672: 5668: 5664: 5660: 5656: 5648: 5646: 5629: 5625: 5621: 5617: 5610: 5602: 5598: 5593: 5588: 5584: 5580: 5577:(13): e3165. 5576: 5572: 5568: 5561: 5553: 5549: 5544: 5539: 5535: 5531: 5527: 5523: 5519: 5512: 5504: 5500: 5495: 5490: 5487:(3): 252–60. 5486: 5482: 5478: 5471: 5463: 5459: 5454: 5449: 5444: 5439: 5435: 5431: 5427: 5420: 5412: 5408: 5403: 5398: 5394: 5390: 5386: 5382: 5378: 5371: 5369: 5360: 5356: 5351: 5346: 5341: 5336: 5332: 5328: 5324: 5320: 5316: 5309: 5307: 5305: 5296: 5292: 5287: 5282: 5278: 5274: 5270: 5266: 5262: 5255: 5253: 5251: 5231: 5227: 5223: 5219: 5215: 5210: 5205: 5201: 5197: 5193: 5189: 5182: 5175: 5173: 5171: 5169: 5160: 5156: 5152: 5148: 5144: 5140: 5136: 5132: 5124: 5115: 5110: 5106: 5102: 5096: 5081: 5077: 5071: 5055: 5051: 5047: 5041: 5022: 5018: 5016: 5007: 5001: 4999: 4982: 4978: 4971: 4969: 4967: 4950: 4946: 4940: 4936: 4935: 4927: 4925: 4908: 4904: 4900: 4894: 4892: 4883: 4879: 4875: 4871: 4867: 4863: 4859: 4855: 4848: 4846: 4844: 4827: 4823: 4819: 4815: 4809: 4805: 4801: 4794: 4792: 4790: 4781: 4777: 4772: 4767: 4763: 4759: 4755: 4751: 4747: 4740: 4738: 4736: 4734: 4732: 4730: 4721: 4717: 4713: 4707: 4703: 4699: 4695: 4688: 4686: 4684: 4682: 4662: 4658: 4654: 4650: 4646: 4642: 4638: 4634: 4630: 4623: 4616: 4614: 4612: 4610: 4608: 4591: 4587: 4583: 4579: 4575: 4571: 4567: 4563: 4559: 4555: 4548: 4546: 4537: 4533: 4528: 4523: 4519: 4515: 4511: 4504: 4502: 4493: 4489: 4485: 4481: 4477: 4473: 4466: 4464: 4462: 4453: 4449: 4445: 4441: 4437: 4433: 4426: 4424: 4415: 4411: 4407: 4403: 4399: 4395: 4387: 4385: 4373: 4369: 4362: 4356: 4354: 4352: 4350: 4348: 4339: 4335: 4331: 4327: 4323: 4319: 4315: 4311: 4304: 4296: 4292: 4288: 4284: 4277: 4275: 4266: 4262: 4258: 4254: 4250: 4246: 4242: 4238: 4231: 4229: 4227: 4218: 4214: 4209: 4204: 4200: 4196: 4192: 4188: 4184: 4177: 4175: 4166: 4162: 4157: 4152: 4148: 4144: 4141:(2): 99–144. 4140: 4136: 4132: 4125: 4123: 4121: 4119: 4117: 4115: 4113: 4111: 4109: 4107: 4105: 4103: 4094: 4088: 4084: 4077: 4068: 4063: 4059: 4055: 4051: 4045: 4043: 4034: 4030: 4025: 4020: 4016: 4012: 4008: 4004: 4000: 3993: 3991: 3974: 3970: 3966: 3960: 3958: 3956: 3939: 3935: 3931: 3925: 3909: 3905: 3901: 3895: 3893: 3876: 3872: 3868: 3862: 3846: 3842: 3838: 3832: 3830: 3828: 3826: 3824: 3822: 3820: 3818: 3816: 3799: 3795: 3791: 3785: 3769: 3765: 3764: 3763:Health Canada 3759: 3753: 3737: 3733: 3732: 3731:Health Canada 3727: 3721: 3705: 3701: 3697: 3693: 3687: 3671: 3667: 3661: 3646: 3642: 3638: 3632: 3624: 3620: 3615: 3610: 3606: 3602: 3598: 3594: 3590: 3583: 3581: 3579: 3570: 3566: 3562: 3558: 3554: 3550: 3546: 3542: 3535: 3533: 3531: 3529: 3527: 3525: 3523: 3521: 3519: 3517: 3515: 3513: 3511: 3509: 3507: 3505: 3503: 3501: 3499: 3497: 3495: 3493: 3476: 3472: 3468: 3462: 3458: 3448: 3445: 3444: 3438: 3436: 3426: 3418: 3416: 3415:methcathinone 3412: 3411:narcotic drug 3402: 3388: 3384: 3382: 3379:In 2017, the 3377: 3373: 3369: 3367: 3362: 3358: 3355: 3350: 3345: 3342: 3338: 3334: 3330: 3329:Nariman Mehta 3322: 3317: 3277: 3269: 3268: 3265: 3262: 3258: 3256: 3251: 3247: 3243: 3242:propiophenone 3233: 3230: 3228: 3224: 3220: 3216: 3211: 3209: 3205: 3202: 3201:hydrochloride 3198: 3194: 3186: 3174: 3170: 3167: 3162: 3160: 3156: 3152: 3148: 3144: 3140: 3136: 3132: 3128: 3124: 3120: 3116: 3112: 3108: 3104: 3100: 3090: 3088: 3084: 3078: 3074: 3072: 3068: 3063: 3061: 3059: 3054: 3052: 3047: 3043: 3039: 3035: 3031: 3027: 3025: 3020: 3019: 3014: 3010: 3006: 3001: 2999: 2995: 2987: 2975: 2966: 2964: 2961: 2957: 2953: 2949: 2944: 2942: 2938: 2934: 2930: 2919: 2897: 2894: 2887: 2882: 2880: 2876: 2872: 2868: 2864: 2856: 2852: 2844: 2839: 2837: 2833: 2829: 2825: 2821: 2817: 2813: 2809: 2807: 2802: 2798: 2796: 2791: 2789: 2784: 2780: 2776: 2772: 2768: 2764: 2755: 2715: 2711: 2707: 2701: 2699:34,000–69,000 2698: 2693: 2688: 2687: 2683: 2677: 2674: 2672: 2666: 2665: 2661: 2655: 2652: 2650: 2640: 2639: 2635: 2629: 2627:12,000–14,000 2626: 2624: 2610: 2609: 2605: 2599: 2596: 2594: 2580: 2579: 2575: 2569: 2566: 2564: 2550: 2549: 2545: 2539: 2536: 2534: 2520: 2519: 2515: 2509: 2506: 2504: 2494: 2493: 2489: 2483: 2480: 2478: 2472: 2471: 2467: 2461: 2458: 2456: 2450: 2449: 2445: 2439: 2436: 2434: 2424: 2423: 2419: 2413: 2410: 2408: 2398: 2397: 2387: 2366: 2357: 2352: 2347: 2346: 2336: 2315: 2306: 2301: 2296: 2295: 2285: 2264: 2255: 2250: 2245: 2244: 2240: 2237: 2234: 2231: 2230: 2214: 2211: 2208: 2205: 2202: 2200: 2193: 2189: 2186: 2183: 2180: 2177: 2174: 2162: 2158: 2155: 2152: 2149: 2146: 2143: 2132: 2128: 2125: 2122: 2119: 2116: 2113: 2102: 2098: 2095: 2092: 2089: 2086: 2083: 2079: 2075: 2072: 2069: 2066: 2063: 2060: 2056: 2052: 2049: 2046: 2043: 2040: 2037: 2033: 2029: 2021: 2017: 2014: 2011: 2008: 2005: 2001: 1997: 1994: 1991: 1988: 1985: 1983:to bupropion 1980: 1976: 1971: 1968: 1962: 1956: 1950: 1944: 1938: 1932: 1926: 1915: 1904: 1902: 1898: 1893: 1891: 1887: 1883: 1879: 1875: 1871: 1866: 1864: 1860: 1856: 1855:nortriptyline 1852: 1848: 1844: 1840: 1836: 1833: 1829: 1825: 1821: 1817: 1813: 1808: 1806: 1802: 1798: 1794: 1793:phenobarbital 1790: 1786: 1782: 1778: 1774: 1773:carbamazepine 1770: 1766: 1762: 1758: 1754: 1750: 1749:norfluoxetine 1746: 1742: 1738: 1734: 1724: 1722: 1718: 1714: 1710: 1706: 1702: 1692: 1690: 1685: 1682: 1677: 1675: 1671: 1666: 1663: 1659: 1658:boxed warning 1649: 1647: 1642: 1640: 1635: 1633: 1629: 1624: 1622: 1618: 1613: 1610: 1606: 1604: 1599: 1597: 1590: 1580: 1578: 1574: 1571:, and severe 1570: 1566: 1562: 1558: 1554: 1550: 1546: 1542: 1532: 1523:(Auvelity; 45 1522: 1510: 1506: 1481: 1477: 1474: 1473:hydrochloride 1470: 1467: 1461: 1457: 1447: 1445: 1440: 1438: 1434: 1433:animal models 1430: 1426: 1422: 1418: 1414: 1410: 1405: 1403: 1399: 1395: 1384: 1382: 1378: 1374: 1370: 1359: 1357: 1356:meta-analysis 1353: 1349: 1345: 1341: 1337: 1327: 1325: 1321: 1317: 1313: 1309: 1305: 1301: 1291: 1287: 1285: 1281: 1276: 1272: 1269: 1265: 1255: 1253: 1247: 1244: 1240: 1236: 1230: 1228: 1224: 1219: 1216: 1212: 1207: 1203: 1202:meta-analyses 1200:is low. Some 1199: 1195: 1191: 1190:effectiveness 1179:Wellbutrin XL 1177: 1168: 1166: 1158: 1154: 1153:Nariman Mehta 1149: 1147: 1143: 1139: 1135: 1131: 1127: 1123: 1120:(NDRI) and a 1119: 1114: 1112: 1108: 1104: 1100: 1096: 1092: 1088: 1084: 1080: 1076: 1072: 1068: 1064: 1060: 1056: 1052: 1047: 1045: 1040: 1036: 1032: 1028: 1024: 1020: 1016: 1012: 1008: 1004: 994: 987: 978: 973: 972: 969: 962: 953: 952: 949: 942: 935: 931: 930: 928: 925: 920: 913: 911: 907: 883: 881: 877: 872: 864: 860: 859:DTXSID7022706 856: 855: 853: 844: 840: 833: 829: 828: 826: 824: 820: 813: 809: 808: 806: 804: 800: 793: 789:as HCl: 788: 785: 781: 780: 778: 776: 772: 765: 761: 760: 758: 756: 752: 745: 741: 740: 738: 736: 732: 725: 721: 720: 718: 716: 712: 705: 701: 700: 698: 696: 692: 685: 681: 680: 678: 671: 667: 660: 654: 648: 644: 643: 641: 639: 635: 627: 623: 618: 617: 614: 607: 602: 598: 581: 578: 576: 572: 530: 528: 521: 512: 504: 496: 489: 487: 483: 479: 475: 471: 468: 466: 462: 454: 452: 448: 444: 442: 438: 434: 430: 423: 421: Rx-only 414: 411: 399: 396: 386: 384: 375: 372: 362: 359: 349: 348: 346: 344: 340: 335: 327: 322: 319: 318: 316: 314: 310: 307: 304: 301: 299: 295: 291: 288: 286: 280: 274: 265: 264: 262: 260: 254: 247: 242: 233: 232: 230: 228: 224: 220: 216: 214: 210: 206: 202: 200: 196: 192: 188: 184: 178: 174: 168: 164: 160: 156: 152: 150: 146: 142: 141: 132: 131: 120: 79: 77:Pronunciation 75: 72:Clinical data 70: 63: 58: 54: 49: 41: 37: 33: 32:Buprenorphine 19: 27447:Aphrodisiacs 27377: 27353:Side Effects 27351: 27323: 27316: 27309: 27302: 27295: 27271:Andrew Witty 27256:Mahlon Kline 27207:Vivienne Cox 27020: 26976:H5N1 vaccine 26903: 26893: 26737:acquisitions 26675:Subsidiaries 26606:Solriamfetol 26521:Famprofazone 26427: 26419: 26405:-Octopamine) 26402: 26399:Norfenefrine 26354:Metanephrine 26346: 26302:Isoprenaline 26258:(Dextrodopa) 26243:Adrenochrome 26201:Pyrovalerone 26107: 26086: 26045:Entactogens: 26044: 25994:Entactogens: 25993: 25940:Ethcathinone 25924: 25856: 25835: 25824:Entactogens: 25823: 25786: 25779:Phentermines 25742: 25591:Entactogens: 25590: 25587:Zylofuramine 25365:Fenfluramine 25360:Fenethylline 25310:Amphetaminil 25291:Amfepentorex 25252: 25110: 25103:Amphetamines 25084: 25068:Entactogens: 25067: 25053: 25045: 25037: 25029: 24993: 24991: 24967:Metaescaline 24569: 24509: 24508: 24463:Promethazine 24448:Perphenazine 24428:Fluphenazine 24403:Clocapramine 24378:Carvotroline 24354: 24344: 24280:Antagonists: 24279: 24239: 24115: 24066:Antagonists: 24065: 23967: 23839:Clomipramine 23775: 23760: 23753: 23732:Progesterone 23619:Antagonists: 23618: 23582:Pregnenolone 23469:Escitalopram 23389:Cloperastine 23364:Blarcamesine 23320: 23253: 23244: 23231: 23222: 23213: 23204: 23193: 23192: 23148: 23136:Vortioxetine 23122:fluphenazine 23096:clomipramine 22991:JNJ-18038683 22981:methysergide 22892:fluperlapine 22872:aripiprazole 22861:Antagonists: 22860: 22825:frovatriptan 22757: 22698: 22663:clomipramine 22571:Landipirdine 22561:Idalopirdine 22546:Cerlapirdine 22493:fluperlapine 22477:aripiprazole 22465:Antagonists: 22464: 22373:methysergide 22337: 22298:methysergide 22286: 22257:Antagonists: 22256: 22207: 22141:Antagonists: 22140: 22083:Prucalopride 22029: 21987: 21965:Vortioxetine 21879:Palonosetron 21823: 21768:Antagonists: 21767: 21645: 21577: 21559:thioridazine 21395:Medifoxamine 21350:methysergide 21302:Deramciclane 21256:paliperidone 21240:fluperlapine 21211:Antagonists: 21210: 21090:aripiprazole 20973:ergine (LSA) 20816: 20779: 20684:Sarpogrelate 20534:aripiprazole 20518:Antagonists: 20517: 20394:methysergide 20329:fenfluramine 20313:Amphetamines 20299: 20258: 20236:Volinanserin 20222:thioridazine 20194:perphenazine 20182:fluphenazine 20124:Teniloxazine 20075:Sarpogrelate 20065:Roluperidone 20035:Pimavanserin 20015:Nelotanserin 19990:Medifoxamine 19975:Landipirdine 19935:methysergide 19906:Eplivanserin 19896:Deramciclane 19851:paliperidone 19819:fluperlapine 19807:clocapramine 19803:carpipramine 19787:aripiprazole 19732:5-MeO-NBpBrT 19724:Antagonists: 19723: 19496:ergine (LSA) 19318:2CBFly-NBOMe 19277: 19225:Antagonists: 19224: 19168:methysergide 19139: 19095: 19080:Antagonists: 19079: 19041:methysergide 19028: 18978: 18883:Antagonists: 18882: 18839:zolmitriptan 18823:frovatriptan 18757:methysergide 18714: 18669: 18565:Antagonists: 18564: 18552:Vortioxetine 18519:zolmitriptan 18474:methysergide 18415: 18368: 18336:Spiroxatrine 18155:Antagonists: 18154: 17905:methysergide 17822:tandospirone 17768:aripiprazole 17758:vortioxetine 17711: 17501:Tubocurarine 17431:Promegestone 17426:Progesterone 17341:Mecamylamine 17151:Cyclopropane 17141:Coronaridine 17105: 17073:Barbiturates 17058:Anatruxonium 17028:α-cobratoxin 16871:Sazetidine A 16791:JNJ-39393406 16781:Ispronicline 16492: 16491: 16476: 16464: 16461: 16451: 16361:Bietaserpine 16333:Amphetamines 16256:Mifepristone 16246:Medifoxamine 16128: 16071:Clomipramine 16066:Cianopramine 16057: 15910:Diclofensine 15880:Brasofensine 15856: 15780: 15768:Vortioxetine 15719: 15638:Escitalopram 15594: 15516:Indeloxazine 15508: 15445: 15428:Oxaprotiline 15409: 15397:Trimipramine 15352:Clomipramine 15347:Cianopramine 15342:Butriptyline 15333: 15186:Diclofensine 15156:Brasofensine 15132: 15056: 15044:Solriamfetol 14978: 14970: 14953:Teniloxazine 14913:Esreboxetine 14884: 14816:Solriamfetol 14736:Medifoxamine 14626:Dimethocaine 14616:Diclofensine 14588: 14583: 14540: 14428:Difluoropine 14423:Dichloropane 14408:Brasofensine 14394: 14382:Pyrovalerone 14358: 14283:Piperidines: 14282: 14232:Piperazines: 14231: 14147: 14146: 14130: 14113: 14096:amphetamines 14087:Phentolamine 14041: 14013:acecarbromal 13981:progesterone 13977:Progestogens 13941:testosterone 13929:Sex steroids 13841:Melanotan II 13529:+semaglutide 13525:Cagrilintide 13481:Orforglipron 13351:Pyrovalerone 13300:+phentermine 13296:Fenfluramine 13291:Fenbutrazate 13265: 13177:Zylofuramine 13112:Fenethylline 13042:Amphetaminil 13027:Amfepentorex 13004:Amphetamines 12930:Barbiturates 12928: 12901: 12884: 12854: 12805: 12778: 12738: 12714: 12700: 12668: 12638: 12629:Mecamylamine 12613: 12495:Oxitriptan ( 12487: 12371:aripiprazole 12329: 12278:Metralindole 12269: 12239: 12229: 12208:Pivhydrazine 12198:Pheniprazine 12144: 12050:Trimipramine 12040:Quinupramine 11940:Clomipramine 11935:Butriptyline 11858:Teniloxazine 11853:Tandospirone 11838:Metryptamine 11833:Medifoxamine 11818:Indeloxazine 11772:Vortioxetine 11672: 11534:Escitalopram 11421: 11417: 11407: 11382: 11378: 11372: 11347: 11343: 11337: 11318: 11312: 11300:. Retrieved 11291: 11282: 11263: 11257: 11249: 11242:. Retrieved 11224: 11191: 11187: 11181: 11156: 11152: 11146: 11116:(1): 65–69. 11113: 11109: 11103: 11084: 11057: 11053: 11047: 11014: 11010: 10989:. Retrieved 10980: 10970: 10958:. Retrieved 10949: 10940: 10928:. Retrieved 10916: 10903: 10891:. Retrieved 10882: 10872: 10860:. Retrieved 10851: 10841: 10829:. Retrieved 10825:the original 10816: 10807: 10795:. Retrieved 10788:the original 10783: 10779: 10767: 10755:. Retrieved 10751:the original 10737: 10725:. Retrieved 10712: 10703: 10691:. Retrieved 10672: 10650:. Retrieved 10615:. Retrieved 10611:the original 10604: 10595: 10583:. Retrieved 10579:the original 10572: 10562: 10550:. Retrieved 10546:the original 10536: 10524:. Retrieved 10520:the original 10510: 10498:. Retrieved 10482: 10470: 10458:. Retrieved 10445: 10436: 10424:. Retrieved 10411: 10402: 10390:. Retrieved 10386:the original 10381: 10377: 10352:. Retrieved 10338: 10326:. Retrieved 10322:the original 10312: 10290:(11): 1479. 10287: 10283: 10277: 10242: 10238: 10228: 10201: 10197: 10187: 10155:(1): 53–54. 10152: 10148: 10138: 10126:. Retrieved 10111: 10104: 10092:. Retrieved 10087: 10063:. Retrieved 10059: 10022: 10018: 10012: 9987: 9983: 9977: 9952: 9948: 9914: 9910: 9866: 9844: 9827: 9823: 9817: 9792: 9788: 9781: 9761: 9754: 9742:. Retrieved 9720:(6): 903–7. 9717: 9713: 9667: 9663: 9629: 9625: 9618: 9586:(1): 142–5. 9583: 9579: 9569: 9536: 9532: 9526: 9493: 9489: 9483: 9459:(4): 251–7. 9456: 9452: 9442: 9407: 9403: 9381: 9361: 9357: 9351: 9326: 9322: 9316: 9279: 9275: 9265: 9243:(1): 81–92. 9240: 9236: 9229: 9220: 9200: 9196: 9162: 9158: 9112: 9108: 9060: 9056: 9050: 9015: 9011: 9001: 8976: 8972: 8950: 8925: 8921: 8914: 8889: 8885: 8879: 8854: 8850: 8844: 8819: 8815: 8809: 8784: 8780: 8774: 8757: 8753: 8747: 8735:. Retrieved 8731: 8707:. Retrieved 8703: 8678:. Retrieved 8673: 8618: 8614: 8604: 8569: 8565: 8555: 8522: 8518: 8486:(1): 85–93. 8483: 8479: 8473: 8440: 8436: 8390: 8386: 8334: 8330: 8324: 8289: 8285: 8275: 8250: 8246: 8240: 8215: 8211: 8205: 8180:11585/762375 8162: 8158: 8113: 8109: 8099: 8072: 8068: 8058: 8046:. Retrieved 8034: 7992: 7988: 7982: 7957: 7953: 7901: 7897: 7887: 7868: 7862: 7827: 7823: 7813: 7801:. Retrieved 7797:the original 7747:(2): 92–97. 7744: 7740: 7730: 7713: 7709: 7703: 7671:(1): 12–28. 7668: 7664: 7654: 7621: 7617: 7611: 7586: 7582: 7575: 7540: 7536: 7526: 7493: 7489: 7483: 7471:. Retrieved 7438: 7434: 7424: 7394:(1): 63–74. 7391: 7387: 7380: 7370:20 September 7368:. Retrieved 7359: 7350: 7340:20 September 7338:. Retrieved 7288: 7284: 7278: 7253: 7249: 7243: 7218: 7214: 7208: 7199: 7186: 7139: 7135: 7125: 7088: 7084: 7074: 7047: 7043: 7033: 6996: 6992: 6982: 6957: 6953: 6946: 6921: 6917: 6911: 6879:(2): 28–35. 6876: 6872: 6862: 6850:. Retrieved 6841: 6832: 6820:. Retrieved 6807: 6798: 6771: 6767: 6711: 6707: 6697: 6670: 6666: 6656: 6624:(2): 59–74. 6621: 6617: 6607: 6572: 6568: 6558: 6523: 6519: 6509: 6476: 6472: 6466: 6431: 6427: 6389: 6385: 6379: 6344: 6340: 6330: 6285: 6281: 6271: 6236: 6232: 6222: 6187: 6183: 6173: 6146: 6142: 6132: 6105: 6101: 6091: 6056: 6052: 6042: 6007: 6003: 5993: 5960: 5956: 5908: 5904: 5894: 5859: 5855: 5808:(1): 45–53. 5805: 5801: 5791: 5754: 5750: 5740: 5705: 5701: 5691: 5658: 5654: 5632:. Retrieved 5628:the original 5623: 5619: 5609: 5574: 5570: 5560: 5525: 5521: 5511: 5484: 5481:N Engl J Med 5480: 5470: 5433: 5429: 5419: 5384: 5380: 5322: 5318: 5268: 5264: 5237:. Retrieved 5191: 5187: 5134: 5130: 5123: 5114:10665/371090 5104: 5095: 5083:. Retrieved 5079: 5070: 5058:. Retrieved 5049: 5040: 5028:. Retrieved 5012: 4985:. Retrieved 4953:. Retrieved 4933: 4911:. Retrieved 4902: 4857: 4854:J Addict Dis 4853: 4830:. Retrieved 4803: 4753: 4749: 4693: 4668:. Retrieved 4632: 4628: 4594:. Retrieved 4561: 4557: 4517: 4513: 4475: 4471: 4435: 4431: 4397: 4393: 4372:the original 4313: 4309: 4303: 4286: 4282: 4240: 4236: 4190: 4186: 4138: 4134: 4082: 4076: 4057: 4053: 4006: 4002: 3977:. Retrieved 3968: 3942:. Retrieved 3933: 3924: 3912:. Retrieved 3903: 3879:. Retrieved 3870: 3861: 3849:. Retrieved 3840: 3802:. Retrieved 3793: 3784: 3772:. Retrieved 3761: 3752: 3740:. Retrieved 3729: 3720: 3708:. Retrieved 3686: 3674:. Retrieved 3660: 3648:. Retrieved 3640: 3631: 3596: 3592: 3544: 3540: 3479:. Retrieved 3470: 3461: 3432: 3424: 3408: 3405:Legal status 3399: 3385: 3378: 3374: 3370: 3363: 3359: 3346: 3326: 3321:steady-state 3254: 3248:followed by 3239: 3231: 3213:A number of 3212: 3208:hydrobromide 3163: 3150: 3146: 3134: 3130: 3126: 3122: 3118: 3114: 3096: 3079: 3075: 3064: 3057: 3050: 3023: 3017: 3002: 2980: 2945: 2933:amphetamines 2883: 2840: 2820:β-adrenergic 2814:, including 2805: 2794: 2787: 2760: 2753: 2713: 2653:7,900–50,000 2507:7,600–28,000 2411:4,200–16,000 2307:3,640–52,000 1960: 1948: 1936: 1924: 1907:Pharmacology 1894: 1882:theophylline 1867: 1809: 1777:clotrimazole 1765:orphenadrine 1730: 1727:Interactions 1698: 1686: 1684:medication. 1678: 1667: 1655: 1643: 1636: 1625: 1614: 1607: 1603:hypertension 1600: 1592: 1583:Side effects 1573:hypertension 1538: 1511:(Contrave; 8 1505:combinations 1480:hydrobromide 1463: 1441: 1427:and improve 1406: 1390: 1365: 1333: 1297: 1288: 1277: 1273: 1261: 1252:aripiprazole 1248: 1231: 1220: 1187: 1171:Medical uses 1150: 1115: 1067:constipation 1048: 1010: 1007:amfebutamone 1006: 1002: 1001: 990: 657:905818-69-1 651:31677-93-7 ( 625: 621: 524:Elimination 343:Legal status 337:Legal status 227:License data 186: 182: 176: 172: 166: 162: 40: 27467:Dermatoxins 27220:Judy Lewent 26626:Venlafaxine 26591:Pronethalol 26561:Methoxamine 26491:Dizocilpine 26486:Diphenidine 26461:Amidephrine 26422:-Octopamine 26359:Metaraminol 26326:(Droxidopa) 26272:Epinephrine 26262:Dimetofrine 26108:Stimulants: 26087:Stimulants: 25915:Brephedrone 25905:Amfepramone 25857:Stimulants: 25839:Cericlamine 25820:Phentermine 25800:Clortermine 25787:Stimulants: 25567:Sibutramine 25552:Prenylamine 25487:Oxifentorex 25439:Metaraminol 25379:Fenproporex 25350:Fencamfamin 25330:Clobenzorex 25296:Amphetamine 25253:Stimulants: 24994:Stimulants: 24952:Macromerine 24498:Venlafaxine 24478:Remoxipride 24468:Propranolol 24393:Cinnarizine 24293:Lamotrigine 24189:Pentazocine 24184:Noribogaine 24174:Nemonapride 24006:Haloperidol 23932:Spipethiane 23897:Noribogaine 23892:Nemonapride 23887:KCR-12-83.1 23727:Pentazocine 23687:Haloperidol 23592:Pridopidine 23567:Pentazocine 23484:Fluvoxamine 23404:Cyclazocine 23206:Adrenergics 23166:Piperazines 23082:mirtazapine 23074:maprotiline 22985:sergolexole 22977:metergoline 22973:mesulergine 22953:cabergoline 22932:EGIS-12,233 22912:ziprasidone 22900:risperidone 22884:clorotepine 22868:amisulpride 22831:Tryptamines 22724:Piperazines 22581:Masupirdine 22551:EGIS-12,233 22497:iloperidone 22485:clorotepine 22389:Tryptamines 22369:metergoline 22365:mesulergine 22304:Piperazines 22294:metergoline 22234:Tryptamines 22118:Usmarapride 22073:Minesapride 22048:Cinitapride 21996:Piperazines 21955:sevoflurane 21932:Tropisetron 21927:Tropanserin 21916:mirtazapine 21874:Ondansetron 21854:Granisetron 21829:Cilansetron 21814:Batanopride 21781:Arazasetron 21776:Anpirtoline 21715:Tryptamines 21677:Piperazines 21555:pipamperone 21504:mirtazapine 21496:maprotiline 21470:SDZ SER-082 21420:Propranolol 21410:Pirenperone 21360:Etoperidone 21354:sergolexole 21346:metergoline 21342:mesulergine 21317:Eltoprazine 21272:ziprasidone 21264:risperidone 21244:iloperidone 21232:clorotepine 21219:Agomelatine 21214:Adatanserin 21183:Vabicaserin 21137:Tryptamines 21086:Piperazines 20965:cabergoline 20741:mirtazapine 20719:SDZ SER-082 20669:Rauwolscine 20659:Propranolol 20649:Pirenperone 20618:mesulergine 20578:ziprasidone 20574:risperidone 20566:pipamperone 20546:cariprazine 20530:amisulpride 20521:Agomelatine 20456:Tryptamines 20431:Piperazines 20374:cabergoline 20270:nicergoline 20226:thiothixene 20202:pipamperone 20186:haloperidol 20158:mirtazapine 20150:maprotiline 20096:mepiprazole 20084:etoperidone 20055:Rauwolscine 20050:Pruvanserin 20040:Pirenperone 19955:Glemanserin 19950:Flibanserin 19939:sergolexole 19931:metergoline 19927:mesulergine 19871:ziprasidone 19867:zicronapine 19859:risperidone 19843:ocaperidone 19839:mosapramine 19827:iloperidone 19823:gevotroline 19811:clorotepine 19795:blonanserin 19760:hydroxyzine 19742:Adatanserin 19670:Tryptamines 19637:Piperazines 19492:cabergoline 19310:2CBCB-NBOMe 19306:25TFM-NBOMe 19207:Tryptamines 19201:sumatriptan 19197:naratriptan 19062:Tryptamines 18982:Acetryptine 18966:Ziprasidone 18905:metergoline 18845:Tryptamines 18835:sumatriptan 18831:rizatriptan 18827:naratriptan 18815:donitriptan 18807:almotriptan 18741:cabergoline 18677:cabergoline 18616:metergoline 18597:propranolol 18530:Tryptamines 18515:sumatriptan 18507:donitriptan 18449:Eltoprazine 18419:Anpirtoline 18372:Acetryptine 18321:SDZ 216-525 18261:Flopropione 18250:metergoline 18221:propranolol 18166:risperidone 18162:iloperidone 18075:Tryptamines 18020:Rauwolscine 18010:Pardoprunox 17950:Flibanserin 17881:cabergoline 17868:Enciprazine 17863:Eltoprazine 17843:Cannabidiol 17818:perospirone 17796:ziprasidone 17780:cariprazine 17734:etoperidone 17725:Amphetamine 17720:Adatanserin 17606:Pirisudanol 17571:Cyprodenate 17551:Adafenoxate 17466:Surugatoxin 17456:Sevoflurane 17411:Pentolinium 17391:Norketamine 17311:Laudanosine 17241:Erythravine 17231:Encenicline 17216:Dipyrandium 17186:Dextrorphan 17032:α-conotoxin 16991:Antagonists 16976:WAY-317,538 16971:Varenicline 16961:Tropisetron 16951:Tebanicline 16896:SSR-180,711 16861:Rivanicline 16851:Pozanicline 16846:PNU-282,987 16841:PNU-120,596 16836:PHA-709,829 16831:PHA-543,613 16771:Galantamine 16746:Epiboxidine 16741:Epibatidine 16661:Altinicline 16504:Adrenergics 16431:Valbenazine 16421:Rose bengal 16366:Deserpidine 16337:amphetamine 16287:levorphanol 16231:Dextrorphan 16184:ziprasidone 16166:pheniramine 16101:Lofepramine 16081:Desipramine 16030:Tesofensine 16020:Sibutramine 15995:Perafensine 15955:JNJ-7925476 15950:Indatraline 15895:Dasotraline 15865:Amifitadine 15844:Venlafaxine 15824:Milnacipran 15723:Etoperidone 15703:Seproxetine 15693:Pirandamine 15673:Omiloxetine 15653:Fluvoxamine 15613:Cericlamine 15603:Alaproclate 15550:levorphanol 15479:ziprasidone 15461:pheniramine 15433:Setiptiline 15418:Maprotiline 15377:Lofepramine 15357:Desipramine 15306:Tesofensine 15296:Sibutramine 15271:Perafensine 15231:JNJ-7925476 15226:Indatraline 15171:Dasotraline 15141:Amifitadine 15120:Venlafaxine 15095:Milnacipran 15024:Nomifensine 14989:Fencamfamin 14918:Lortalamine 14908:Edivoxetine 14898:Ciclazindol 14893:Alseroxylon 14841:Venlafaxine 14821:Tametraline 14811:Sibutramine 14786:Perafensine 14766:Nomifensine 14696:Indatraline 14671:Fencamfamin 14646:DOV-216,303 14641:DOV-102,677 14601:Dasotraline 14596:Ciclazindol 14554:Armodafinil 14549:Amifitadine 14498:Tesofensine 14306:Difemetorex 14110:Rauwolscine 14067:Mirtazapine 14062:Flibanserin 14032:Alprostadil 13889:Mirodenafil 13803:Quinagolide 13798:Pramipexole 13778:Cabergoline 13773:Apomorphine 13696:from market 13645:Metreleptin 13581:Mitratapide 13576:Dirlotapide 13506:Tirzepatide 13496:Semaglutide 13491:Retatrutide 13476:Liraglutide 13465:Ecnoglutide 13460:Danuglipron 13390:Ibipinabant 13377:antagonists 13375:Cannabinoid 13361:Tesofensine 13356:Sibutramine 13286:Difemetorex 13270:+naltrexone 13256:Atomoxetine 13225:Terbutaline 13200:Clenbuterol 13166:+topiramate 13162:Phentermine 13117:Fenproporex 13077:Clortermine 13067:Clobenzorex 13037:Amphetamine 13032:Amfepramone 12684:Acamprosate 12634:Varenicline 12534:from market 12477:brexanolone 12391:risperidone 12288:Moclobemide 12270:Reversible: 12230:Reversible: 12153:Iproclozide 12088:Setiptiline 12083:Mirtazapine 12073:Maprotiline 12030:Propizepine 12015:Noxiptiline 12000:Metapramine 11990:Lofepramine 11960:Dimetacrine 11950:Desipramine 11823:Flupentixol 11808:Etryptamine 11793:Amisulpride 11788:Agomelatine 11734:Etoperidone 11711:Setiptiline 11706:Mirtazapine 11678:Nomifensine 11635:Atomoxetine 11612:Venlafaxine 11602:Milnacipran 11544:Fluvoxamine 10930:26 November 10893:26 November 10862:26 February 10831:20 December 10797:16 December 10056:"Bupropion" 9949:Xenobiotica 7618:Drug Safety 7473:13 November 7360:AdisInsight 7108:10852/63759 6924:: 129–135. 5387:: e067606. 5239:13 December 5194:: 393–398. 4899:"Bupropion" 4558:Drug Safety 4067:10665/58135 3481:24 December 3421:Brand names 3257:-butylamine 3183:ClNO and a 3143:enantiomers 3099:aminoketone 3087:reinforcing 3015:leading to 3011:isoenzymes 2773:of several 2769:(NDRI) and 2313:1,400–1,900 2203:87 (mouse) 2023:Inhibition 1859:venlafaxine 1835:dextrorphan 1824:atomoxetine 1820:desipramine 1805:Ticlopidine 1761:clopidogrel 1705:venlafaxine 1652:Psychiatric 1369:sibutramine 1362:Weight gain 1320:amphetamine 1308:atomoxetine 1284:varenicline 1243:hypersomnia 1215:unpublished 1211:variability 1206:effect size 1130:aminoketone 1039:hypersomnia 917: g·mol 604:Identifiers 486:Metabolites 213:MedlinePlus 158:Other names 149:Trade names 27517:Stimulants 27457:Cathinones 27432:Anorectics 27416:Categories 27289:Litigation 27276:Chris Gent 27225:Urs Rohner 27133:Parodontax 26941:Engerix-B 26754:Block Drug 26596:Salbutamol 26531:Hexapradol 26511:Etafedrine 26506:Ephenidine 26501:Dopexamine 26496:Dobutamine 26476:Denopamine 26466:Arbutamine 26440:Synephrine 26374:Methyldopa 26369:Metirosine 26317:(Levodopa) 26307:Isoetarine 26292:Fenclonine 26282:Etilefrine 26196:Prolintane 26027:Mephedrone 25990:Radafaxine 25980:Pentedrone 25960:Methedrone 25920:Buphedrone 25910:Benzedrone 25849:Cathinones 25761:Selegiline 25751:Amiflamine 25547:Pholedrine 25497:Ortetamine 25492:Oxilofrine 25424:Lefetamine 25414:Iofetamine 25399:Furfenorex 25394:Formetorex 25384:Flucetorex 25315:Benfluorex 25286:Amfecloral 25281:Alfetamine 25154:D-Deprenyl 25071:Lophophine 24982:Psi-2C-T-4 24977:Proscaline 24947:Jimscaline 24483:SL 82.0715 24398:Cinuperone 24373:Caramiphen 24368:Butaclamol 24268:Tapentadol 24199:Safinamide 24179:Nepinalone 24144:Clemastine 24139:5-MeO-DiPT 24134:5-MeO-DALT 24011:Ifenprodil 23976:Arketamine 23927:Selegiline 23922:Safinamide 23882:Imipramine 23844:Clorgiline 23834:Clemastine 23824:Azidopamil 23814:5-MeO-DiPT 23809:5-MeO-DALT 23742:Sertraline 23542:Nepinalone 23489:Ifenprodil 23479:Fluoxetine 23444:Dimemorfan 23413:prasterone 23374:Citalopram 23369:Captodiame 23349:Arketamine 23344:Amantadine 23302:modulators 23100:imipramine 23061:SSR-181507 23036:SB-656104A 23011:Ritanserin 23001:LY-215,840 22996:Ketanserin 22969:LY-215,840 22961:ergotamine 22945:amesergide 22922:Butaclamol 22908:tiospirone 22904:sertindole 22896:olanzapine 22771:Bifeprunox 22714:lergotrile 22611:Ro 63-0563 22606:Ro 04-6790 22601:Ritanserin 22566:Ketanserin 22505:tiospirone 22501:olanzapine 22452:WAY-208466 22447:WAY-181187 22441:tryptamine 22421:EMD-386088 22353:ergotamine 22275:Ritanserin 22219:ergotamine 22123:Velusetrag 22093:Renzapride 21975:Zatosetron 21894:Ricasetron 21889:Renzapride 21884:Ramosetron 21864:Lerisetron 21844:Dolasetron 21803:quetiapine 21799:olanzapine 21741:isoflurane 21565:Xylamidine 21488:aptazapine 21425:Ritanserin 21405:Nefazodone 21380:Ketanserin 21375:Irindalone 21365:Fluoxetine 21338:LY-215,840 21326:amesergide 21312:Dotarizine 21292:Cinanserin 21282:Captodiame 21268:sertindole 21260:quetiapine 21252:olanzapine 21193:WAY-161503 21177:tryptamine 21173:psilocybin 21117:PNU-181731 21076:lophophine 21062:Oxaflozane 21020:Lorcaserin 21015:Flumexadol 20977:ergotamine 20858:5-MeO-DiPT 20674:Ritanserin 20639:Metadoxine 20624:Ketanserin 20598:amesergide 20570:quetiapine 20562:olanzapine 20504:tryptamine 20500:psilocybin 20404:Lorcaserin 20386:ergotamine 20241:Xylamidine 20210:setoperone 20142:aptazapine 20129:Temanogrel 20100:nefazodone 20092:lubazodone 20060:Ritanserin 20025:Pelanserin 19965:Ketanserin 19960:Irindalone 19945:Fananserin 19923:LY-215,840 19915:amesergide 19901:Dotarizine 19886:Cinanserin 19863:sertindole 19855:quetiapine 19847:olanzapine 19831:lurasidone 19783:amperozide 19747:Altanserin 19727:5-I-R91150 19710:tryptamine 19706:psilocybin 19627:lophophine 19608:PNU-181731 19593:Oxaflozane 19561:Lorcaserin 19556:Jimscaline 19546:Flumexadol 19504:ergotamine 19372:5-MeO-DiPT 19193:eletriptan 19174:Lasmiditan 19148:CP-122,288 19066:tryptamine 19056:eletriptan 18956:Ritanserin 18916:Ketanserin 18891:BRL-15,572 18819:eletriptan 18811:avitriptan 18788:PNU-142633 18783:PNU-109291 18749:ergotamine 18718:CP-122,288 18627:Isamoltane 18601:tertatolol 18593:penbutolol 18589:oxprenolol 18585:isamoltane 18577:alprenolol 18568:AR-A000002 18511:eletriptan 18503:avitriptan 18466:ergotamine 18439:CP-122,288 18424:CGS-12066A 18377:Carvedilol 18356:Xylamidine 18351:WAY-100635 18346:WAY-100135 18316:SB-649,915 18306:Robalzotan 18271:Isamoltane 18241:Dotarizine 18225:tertatolol 18209:penbutolol 18205:oxprenolol 18201:isamoltane 18185:alprenolol 18170:sertindole 18137:Xaliproden 18132:Vilazodone 18122:U-92,016-A 18111:psilocybin 18099:indorenate 18070:Sunepitron 18065:SSR-181507 18015:Piclozotan 18005:Oxaflozane 18000:Osemozotan 17965:Lesopitron 17955:Flumexadol 17945:Flesinoxan 17889:ergotamine 17828:Bay R 1531 17810:eptapirone 17802:Azapirones 17792:quetiapine 17788:lurasidone 17754:vilazodone 17742:nefazodone 17677:modulators 17566:Citicoline 17546:Acetyl-coA 17530:Precursors 17506:Vanoxerine 17496:Tropeinium 17481:Toxiferine 17446:Reboxetine 17436:Radafaxine 17381:Neramexane 17371:Mivacurium 17366:Metocurine 17331:Malouetine 17296:Isoflurane 17251:Fazadinium 17246:Esketamine 17226:Doxacurium 17211:Dioscorine 17171:Desflurane 17136:Coclaurine 17068:Atracurium 17053:Amantadine 17043:Alcuronium 16796:Levamisole 16786:Ivermectin 16731:Dianicline 16691:Butinoline 16676:Anatoxin-a 16565:modulators 16480:SoRI-20041 16473:SoRI-20040 16401:Ketanserin 16328:Amiodarone 16291:tapentadol 16251:Mesembrine 16221:Delucemine 16198:esketamine 16111:Pipofezine 16096:Imipramine 16015:SEP-228432 16010:SEP-228431 15980:Nefazodone 15965:Liafensine 15935:Fezolamine 15925:DOV-216303 15920:DOV-102677 15875:Bicifadine 15870:Ansofaxine 15809:Eclanamine 15804:Duloxetine 15789:Bicifadine 15763:Vilazodone 15733:Lubazodone 15728:Litoxetine 15713:Zimelidine 15708:Sertraline 15683:Paroxetine 15678:Panuramine 15648:Fluoxetine 15643:Femoxetine 15623:Dapoxetine 15618:Citalopram 15542:tapentadol 15521:Nefazodone 15504:Ephenidine 15499:Dopexamine 15382:Melitracen 15372:Imipramine 15291:SEP-228432 15286:SEP-228431 15256:Nefazodone 15241:Liafensine 15211:Fezolamine 15201:DOV-216303 15196:DOV-102677 15151:Bicifadine 15146:Ansofaxine 15105:Nafenodone 15080:Eclanamine 15075:Duloxetine 15034:Radafaxine 15014:Manifaxine 14999:Lefetamine 14974:Amineptine 14958:Viloxazine 14933:Reboxetine 14928:Nisoxetine 14806:Sertraline 14796:Radafaxine 14781:Oroxylin A 14726:Manifaxine 14716:Liafensine 14706:Lefetamine 14686:GYKI-52895 14676:Fezolamine 14661:Esketamine 14656:Ephenidine 14579:BTS 74,398 14569:Ansofaxine 14564:Amineptine 14443:FP-β-CPPIT 14438:FE-β-CPPIT 14377:Prolintane 14270:Vanoxerine 14265:Nefazodone 14082:Papaverine 14072:Moxisylyte 14057:Dapoxetine 14037:Amantadine 13985:progestins 13919:Vardenafil 13899:Sildenafil 13869:Aildenafil 13813:Rotigotine 13808:Ropinirole 13670:Zonisamide 13660:Topiramate 13650:Naltrexone 13630:Bimagrumab 13601:Uncouplers 13591:Simmondsin 13571:Cetilistat 13555:Lorcaserin 13455:Cotadutide 13450:Cinchonine 13415:Taranabant 13410:Surinabant 13405:Rosonabant 13400:Rimonabant 13306:Manifaxine 13261:Benfluorex 13220:Synephrine 13127:Furfenorex 13022:Amfecloral 12995:Stimulants 12982:Anorectics 12861:Naltrexone 12795:Lofexidine 12734:Topiramate 12722:Naltrexone 12679:Disulfiram 12509:Tryptophan 12481:zuranolone 12387:quetiapine 12383:olanzapine 12379:lurasidone 12333:Selegiline 12323:-selective 12303:Toloxatone 12298:Tetrindole 12293:Pirlindole 12273:Eprobemide 12263:-selective 12243:Bifemelane 12233:Caroxazone 12193:Phenelzine 12178:Mebanazine 12158:Iproniazid 12045:Tianeptine 12025:Pipofezine 11995:Melitracen 11975:Imipramine 11955:Dibenzepin 11915:Amineptine 11863:Tianeptine 11848:Pivagabine 11843:Oxaflozane 11803:Esketamine 11767:Vilazodone 11739:Nefazodone 11668:Amineptine 11645:Viloxazine 11640:Reboxetine 11592:Duloxetine 11564:Zimelidine 11559:Sertraline 11554:Paroxetine 11539:Fluoxetine 11529:Citalopram 10991:24 October 10960:24 October 10585:13 October 10552:13 October 10500:21 October 10460:4 December 10426:4 December 9744:25 October 9670:: 173073. 9364:(2): 222. 9012:NeuroImage 8048:1 December 6233:Pediatrics 5757:(6): 116. 5702:CNS Spectr 4822:1249799493 3979:22 October 3914:21 October 3650:22 October 3453:References 3246:brominated 3227:manifaxine 3223:radafaxine 3193:lipophilic 3085:-like and 2235:Value (nM) 2175:nicotinic 2144:nicotinic 2114:nicotinic 2018:22 h 2015:31 h 2012:15 h 2009:19 h 2006:11 h 2003:Half-life 1920:Bupropion 1851:imipramine 1847:metoprolol 1843:heart rate 1832:metabolite 1781:rifampicin 1753:fluoxetine 1745:sertraline 1741:paroxetine 1587:See also: 1547:, such as 1507:including 1454:See also: 1387:Other uses 1318:, such as 1316:stimulants 1268:withdrawal 1235:sleepiness 1184:Depression 1035:sleepiness 1011:Wellbutrin 922:3D model ( 910:Molar mass 812:CHEBI:3219 764:01ZG3TPX31 735:ChemSpider 695:IUPHAR/BPS 647:34911-55-2 638:CAS Number 613:IUPAC name 594:unchanged) 531:Bupropion: 474:intestines 465:Metabolism 298:Drug class 18:Wellbutrin 27359:Study 329 27170:Directors 27168:Board of 27143:Sensodyne 27123:Nicorette 27080:Emergen-C 27075:ChapStick 27055:BC Powder 27050:Aquafresh 26991:Pandemrix 26961:Hepatyrix 26859:Flixonase 26839:Augmentin 26576:PARGY-LAD 26471:Cafedrine 26430:-Tyramine 26384:Nordefrin 26364:Metaterol 26349:-Tyramine 26341:-Tyrosine 26297:Ibopamine 26186:Naphyrone 26017:Methylone 25985:Pentylone 25930:Cathinone 25925:Bupropion 25768:-Deprenyl 25434:Mefenorex 25404:Gepefrine 25355:Fencamine 25340:Ephedrine 25276:Acridorex 25003:Hordenine 24962:Mescaline 24855:2C-T-22.5 24593:25N-NBOMe 24588:25I-NBOMe 24583:25D-NBOMe 24578:25C-NBOMe 24573:25B-NBOMe 24510:See also: 24488:SR-31747A 24473:Quinidine 24458:Proadifen 24443:Molindone 24418:Hypericin 24413:EMD-59983 24363:BMY-13980 24348:SKF-83959 24263:Naluzotan 24243:Berberine 24240:Agonists: 24194:RS-67,333 24129:4-MeO-PCP 24124:3-MeO-PCE 24039:Opipramol 24034:OPC-14523 23968:Agonists: 23907:RS-67,333 23852:-Deprenyl 23804:4-MeO-PCP 23784:3-MeO-PCP 23769:SOMCL-668 23761:Positive: 23757:Phenytoin 23747:SR-31742A 23722:PD-144418 23712:NPC-16377 23562:Opipramol 23557:OPC-14523 23552:Noscapine 23522:Memantine 23464:Eliprodil 23459:Donepezil 23334:5-MeO-DMT 23321:Agonists: 23194:See also: 23160:pergolide 23152:Ergolines 23078:mianserin 23070:amoxapine 23056:Spiperone 23041:SB-691673 23031:SB-656104 23026:SB-269970 23021:SB-258741 23016:SB-258719 22937:Ergolines 22888:clozapine 22876:asenapine 22847:N-Me-5-HT 22843:bufotenin 22811:Sarizotan 22806:RU-24,969 22781:Ergolines 22761:8-OH-DPAT 22758:Agonists: 22718:pergolide 22702:Ergolines 22649:mianserin 22645:amoxapine 22636:SB-742457 22631:SB-399885 22626:SB-357134 22621:SB-271046 22616:SB-258585 22596:PRX-07034 22556:GW-742457 22541:BVT-74316 22531:BGC20-760 22489:clozapine 22481:asenapine 22433:N-Me-5-HT 22429:LY-586713 22409:Bufotenin 22393:2-Me-5-HT 22341:Ergolines 22338:Agonists: 22290:Ergolines 22280:SB-699551 22260:Asenapine 22211:Ergolines 22208:Agonists: 22179:SB-204070 22174:SB-203186 22159:Piboserod 22149:GR-125487 22144:GR-113808 22128:Zacopride 22113:Tegaserod 22103:RS-67,506 22098:RS-67,333 22088:PRX-03140 22078:Mosapride 22063:Dazopride 22058:CJ-033466 22053:Cisapride 22043:Capeserod 22030:Agonists: 21970:Zacopride 21912:mianserin 21908:amoxapine 21869:Memantine 21839:Dazopride 21824:Bupropion 21809:Azasetron 21795:clozapine 21771:Alosetron 21737:halothane 21719:2-Me-5-HT 21710:SR-57227A 21689:quipazine 21646:Agonists: 21586:Ergolines 21581:Efavirenz 21520:Trazodone 21500:mianserin 21484:amoxapine 21465:SB-243213 21460:SB-242084 21455:SB-228357 21450:SB-221284 21445:SB-206553 21440:SB-200646 21430:RS-102221 21415:Pizotifen 21385:Ketotifen 21370:FR-260010 21322:Ergolines 21248:melperone 21236:clozapine 21228:asenapine 21149:bufotenin 21127:Ro60-0213 21122:Ro60-0175 21112:PNU-22394 21102:quipazine 21080:mescaline 21067:PHA-57378 21057:ORG-37684 21052:ORG-12962 21009:pergolide 20957:Ergolines 20930:Dimemebfe 20925:CP-809101 20920:Alstonine 20915:AL-38022A 20896:α-Me-5-HT 20892:5-MeO-αMT 20888:5-MeO-αET 20866:5-MeO-DPT 20862:5-MeO-DMT 20854:5-MeO-DET 20817:Agonists: 20783:Ergolines 20767:Yohimbine 20747:Trazodone 20737:mianserin 20733:amoxapine 20724:Tegaserod 20714:SB-228357 20709:SB-221284 20704:SB-215505 20699:SB-206553 20694:SB-204741 20689:SB-200646 20679:RS-127445 20664:PRX-08066 20654:Pizotifen 20629:LY-393558 20614:LY-272015 20594:Ergolines 20589:EGIS-7625 20550:clozapine 20538:asenapine 20476:bufotenin 20472:α-Me-5-HT 20446:Ro60-0175 20441:PNU-22394 20398:pergolide 20370:Ergolines 20343:BW-723C86 20300:Agonists: 20262:Ergolines 20246:Yohimbine 20218:spiramide 20214:spiperone 20154:mianserin 20138:amoxapine 20114:SR-46349B 20108:trazodone 20045:Pizotifen 20010:Nantenine 19980:LY-393558 19911:Ergolines 19835:melperone 19815:clozapine 19791:asenapine 19768:perlapine 19764:ketotifen 19682:bufotenin 19645:quipazine 19631:mescaline 19603:PNU-22394 19598:PHA-57378 19551:IHCH-7113 19540:pergolide 19476:Ergolines 19471:Efavirenz 19439:Dimemebfe 19429:AL-37350A 19410:α-Me-5-HT 19406:5-MeO-αMT 19402:5-MeO-αET 19380:5-MeO-DPT 19376:5-MeO-DMT 19368:5-MeO-DET 19314:25CN-NBOH 19302:25C-NBOMe 19298:25B-NBOMe 19294:25I-NBOMe 19278:Agonists: 19233:Mianserin 19179:LY-334370 19153:Ergolines 19143:BRL-54443 19140:Agonists: 19099:Ergolines 19037:Ergolines 19032:BRL-54443 19029:Agonists: 18999:pergolide 18987:Ergolines 18961:Yohimbine 18951:Mianserin 18941:LY-456220 18936:LY-456219 18931:LY-393558 18926:LY-367642 18921:LY-310762 18911:GR-127935 18901:Ergolines 18896:Elzasonan 18886:Alniditan 18733:Ergolines 18728:CP-286601 18723:CP-135807 18715:Agonists: 18673:Ergolines 18657:Yohimbine 18652:SB-236057 18647:SB-224289 18642:SB-216641 18632:LY-393558 18622:GR-127935 18612:Ergolines 18607:Elzasonan 18581:carteolol 18489:RU-24,969 18478:pergolide 18454:Ergolines 18444:CP-135807 18416:Agonists: 18382:Ergolines 18331:Spiramide 18326:Spiperone 18276:Lecozotan 18256:FCE-24379 18246:Ergolines 18231:BMY-7,378 18213:pindobind 18189:carteolol 18142:Yohimbine 18103:N-Me-5-HT 18091:bufotenin 18083:5-MeO-DMT 18055:Sarizotan 18035:RU-24,969 18030:Roxindole 18025:Repinotan 17990:Naluzotan 17975:LY-301317 17970:LY-293284 17909:pergolide 17873:Ergolines 17858:Ebalzotan 17848:Dimemebfe 17838:BMY-14802 17833:Befiradol 17806:buspirone 17784:clozapine 17772:asenapine 17746:trazodone 17715:8-OH-DPAT 17712:Agonists: 17406:Pentamine 17401:Pempidine 17351:Methadone 17346:Memantine 17266:Halothane 17256:Gallamine 17236:Enflurane 17191:Diadonium 17106:Bupropion 16891:SIB-1553A 16886:SIB-1508Y 16876:SB-206553 16701:Carbachol 16681:AR-R17779 16671:Anatabine 16666:Anabasine 16631:A-867,744 16626:A-582,941 16621:A-366,833 16493:See also: 16468:SoRI-9804 16416:Reserpine 16386:GBR-12935 16381:Efavirenz 16301:Roxindole 16279:methadone 16266:N-Me-5-HT 16236:Efavirenz 16194:3-MeO-PCP 16137:Amoxapine 16005:Pridefine 15975:Naphyrone 15839:Tofenacin 15758:Trazodone 15748:SB-649915 15743:Quipazine 15738:LY-393558 15663:Ifoxetine 15658:Indalpine 15534:methadone 15423:Mianserin 15413:Amoxapine 15281:Pridefine 15251:Naphyrone 15115:Tofenacin 15065:CP-39,332 14984:Fencamine 14979:Bupropion 14948:Tandamine 14943:Talsupram 14903:Daledalin 14801:Rimcazole 14791:Pridefine 14756:Modafinil 14681:Fluorenol 14651:Efavirenz 14584:Bupropion 14544:Adrafinil 14508:Tropoxane 14398:Altropane 14395:Tropanes: 14372:Naphyrone 14336:Pipradrol 14255:GBR-13098 14250:GBR-13069 14245:GBR-12935 14240:GBR-12783 14148:See also: 14127:Yohimbine 14122:Trazodone 14115:Rauvolfia 14047:Buspirone 14042:Bupropion 14021:vitamin E 14017:quebracho 13959:estradiol 13955:Estrogens 13937:Androgens 13909:Tadalafil 13884:Lodenafil 13818:Terguride 13793:Piribedil 13788:Pergolide 13706:Phase III 13694:Withdrawn 13640:Metformin 13625:Beloranib 13470:Exenatide 13395:Otenabant 13385:Drinabant 13341:Pipradrol 13266:Bupropion 13230:Yohimbine 13205:Ephedrine 13195:Albuterol 13142:Mefenorex 13092:Ephedrine 13057:Cathinone 12913:Lorazepam 12896:Clonidine 12866:Nalmefene 12828:Methadone 12817:+naloxone 12790:Clonidine 12750:Clonidine 12727:Nalmefene 12673:inhibitor 12650:Clonidine 12614:Bupropion 12544:Phase III 12532:Withdrawn 12397:Buspirone 12283:Minaprine 12218:Tedizolid 12213:Safrazine 12188:Octamoxin 12183:Nialamide 12173:Linezolid 12168:Isoniazid 12078:Mianserin 12020:Opipramol 11985:Iprindole 11965:Dosulepin 11930:Amoxapine 11886:Tricyclic 11744:Trazodone 11701:Mianserin 11673:Bupropion 11607:Tofenacin 11549:Indalpine 11498:Specific 11062:CiteSeerX 11060:: 21–46. 10526:19 August 10354:20 August 10328:18 August 10019:Chirality 9692:226292409 9561:257583439 9518:234883621 9434:253283525 9426:2772-4085 9378:1092-8529 9257:0272-4391 8737:19 August 8709:19 August 8704:BindingDB 8680:19 August 8670:Database" 8359:218563059 8197:215758102 7496:: 60–68. 7416:232141396 6954:CNS Drugs 6746:247057961 6004:Addiction 5732:233212535 5085:30 August 5060:30 August 4979:. USPTO. 4882:246238087 4832:27 August 4657:234472488 4586:229357583 4265:195687060 3881:9 January 3804:9 January 3774:9 January 3742:9 January 3676:9 January 3569:163167323 3471:Drugs.com 3236:Synthesis 3215:analogues 3187:of 239.74 3171:with the 3093:Chemistry 3067:half-life 3034:reductive 3005:oxidative 2943:(TAAR1). 2832:histamine 2828:serotonin 2812:receptors 2481:580–2,100 2311:443–3,240 2309:940–1,900 2262:550–2,170 2260:330–2,900 2258:372–2,780 2256:173–1,800 2126:14 (rat) 2096:67 (rat) 2093:inactive 2090:inactive 2087:inactive 2084:, uptake 2073:16 (rat) 2061:, uptake 2050:47 (rat) 2044:inactive 2038:, uptake 1967:bupropion 1955:bupropion 1943:bupropion 1931:bupropion 1863:nebivolol 1801:efavirenz 1785:ritonavir 1717:morbidity 1713:mortality 1681:psychosis 1665:placebo. 1615:Cases of 1402:psoriasis 1394:TNF-alpha 1344:trazodone 1107:pregnancy 1099:psychosis 1085:. Raised 1059:dry mouth 1003:Bupropion 832:ChEMBL894 575:Excretion 526:half-life 480:, others) 283:Routes of 257:Pregnancy 246:Bupropion 205:Monograph 199:Drugs.com 181:3-Chloro- 171:3-Chloro- 140:-teh-moan 45:Bupropion 36:Buspirone 27502:Prodrugs 27406:Medicine 27378:Category 27128:NiQuitin 27118:Nicoderm 27113:Lucozade 27108:Horlicks 27090:Excedrin 27065:Caltrate 27011:Shingrix 27001:Rabavert 26996:Pediarix 26971:Infanrix 26951:FluLaval 26936:Cervarix 26931:Boostrix 26914:Vaccines 26889:Ventolin 26879:Serlipet 26869:Lamictal 26864:Hycamtin 26849:Beconase 26808:Products 26581:Phenibut 26267:Dopamine 26248:Ciladopa 26238:a-Me-TRA 26078:Eutylone 26068:Butylone 26012:Ethylone 26007:Butylone 25997:3,4-DMMC 25945:Eutylone 25895:4-MeMABP 25815:Pentorex 25805:Etolorex 25795:Cloforex 25572:Tiflorex 25464:Morforex 25389:Fludorex 25144:Beatrice 24937:Escaline 24453:Pimozide 24408:Dezocine 24298:Naloxone 24258:Metaphit 24253:Fourphit 24233:Unsorted 24169:Ibogaine 24109:SAS-0132 24059:UKH-1114 24016:Ketamine 24001:DKR-1051 23996:DKR-1005 23877:Ibogaine 23509:L-687384 23504:Ketamine 23156:lisuride 23130:pimozide 23126:loxapine 22965:LY-53857 22916:zotepine 22821:Triptans 22685:loxapine 22536:BVT-5182 22379:Hypidone 22357:lisuride 22169:RS-67532 22164:RS-39604 22154:L-Lysine 21991:LY-53857 21941:loxapine 21834:CSP-2503 21755:YM-31636 21705:SR-57227 21695:RS-56812 21649:Alcohols 21551:pimozide 21547:loxapine 21515:Tramadol 21334:LY-53857 21276:zotepine 21169:psilocin 20985:LA-SS-Az 20981:lisuride 20910:A-372159 20884:5-Fl-αMT 20880:5-Cl-αMT 20610:LY-53857 20606:lisuride 20496:psilocin 20321:cloforex 20308:Aminorex 20198:pimozide 20190:loxapine 20119:TGBA01AD 19919:LY-53857 19891:CSP-2503 19875:zotepine 19737:AC-90179 19702:psilocin 19512:LA-SS-Az 19508:lisuride 19424:AL-34662 19398:5-Fl-αMT 19394:5-Cl-αMT 19354:2C-B-FLY 19290:25I-NBOH 19286:25I-NBMD 19189:Triptans 19161:lysergol 19107:lysergol 19052:Triptans 18995:lysergol 18991:lisuride 18857:5-Et-DMT 18803:Triptans 18798:TGBA01AD 18773:L-772405 18768:L-694247 18763:GR-46611 18685:lisuride 18499:Triptans 18434:CP-94253 18429:CP-93129 18266:GR-46611 18236:CSP-2503 18217:pindolol 18127:Urapidil 18117:TGBA01AD 18107:psilocin 18040:S-14,506 17960:Hypidone 17940:F-15,599 17915:F-11,461 17893:lisuride 17853:Dopamine 17814:gepirone 17618:See also 17560:lecithin 17536:prodrugs 17486:Tramadol 17336:ME-18-MC 17301:Ketamine 17291:Ibogaine 17111:BW284C51 16866:RJR-2429 16856:Pyrantel 16816:Nicotine 16811:Morantel 16801:Lobeline 16766:EVP-6124 16761:EVP-4473 16716:Cytisine 16711:Cotinine 16616:A-84,543 16587:Agonists 16455:Luteolin 16406:Lobeline 16396:Ibogaine 16295:tramadol 16241:Hypidone 16202:ketamine 16180:loxapine 16040:Tropanes 15970:Mazindol 15960:JZ-IV-10 15794:CP-39332 15753:TGBA01AD 15546:tramadol 15489:ketamine 15475:loxapine 15316:Tropanes 15246:Mazindol 15236:JZ-IV-10 14938:Talopram 14923:Mazindol 14888:Amedalin 14746:Metaphit 14741:Mesocarb 14731:Mazindol 14701:Ketamine 14503:Troparil 14260:JJC8-088 14077:Oxytocin 13992:tibolone 13971:Premarin 13947:, other 13914:Udenafil 13874:Avanafil 13783:Lisuride 13665:ZGN-1061 13586:Orlistat 13433:and / or 13311:Mazindol 13251:Aminorex 13157:Pentorex 13122:Fludorex 13107:Etolorex 13072:Cloforex 12923:Oxazepam 12908:Diazepam 12801:Ibogaine 12761:Phenibut 12756:Baclofen 12624:Lobeline 12619:Cytisine 12470:GABAkine 12148:Benmoxin 12104:Tiazesim 11828:Ketamine 11813:Gepirone 11440:11091936 11364:21241211 11296:Archived 11244:28 April 11238:Archived 11216:24870292 11208:27504927 11173:23519045 11130:22468662 11092:Archived 11039:58587857 11031:30601027 10985:Archived 10954:Archived 10921:Archived 10887:Archived 10856:Archived 10721:Archived 10687:Archived 10683:Medscape 10652:23 March 10646:Archived 10617:19 April 10574:NBC News 10491:Archived 10454:Archived 10420:Archived 10348:Archived 10269:21191682 10179:43480769 10171:10999247 10128:4 August 10094:4 August 10065:4 August 10004:30601027 9931:31124380 9893:24484978 9809:15083067 9738:Archived 9734:16644475 9684:33186562 9646:23953570 9610:25670957 9553:36928557 9510:34218389 9475:25657796 9343:26791601 9308:27092049 9217:32746649 9179:18705749 9139:34736882 9085:26035635 9077:16005476 9042:19969097 8993:38287888 8942:15322260 8906:10379421 8645:27671323 8596:31871303 8539:15322260 8500:12909199 8465:19490821 8457:10379421 8417:20509659 8351:32386065 8316:30460996 8267:15554766 8232:18691982 8189:32285503 8140:14761997 8132:25655950 8091:27518170 8039:Archived 7974:16368442 7928:19031375 7854:31288917 7771:25097474 7722:26594724 7695:31595027 7646:25290793 7638:11888352 7603:24267809 7567:28605035 7518:19196303 7510:29715610 7467:Archived 7463:33102792 7455:25874915 7408:33682569 7364:Archived 7334:Archived 7305:32606041 7270:38465412 7235:16030444 7166:18253994 7117:28512664 7066:27167571 7025:16984660 6974:37792265 6938:27018393 6903:18497715 6846:Archived 6842:DailyMed 6816:Archived 6790:15809465 6738:35193485 6689:27916394 6648:29523488 6599:29649948 6550:15361919 6493:19440080 6458:21955201 6406:27813651 6371:30097390 6322:33085721 6282:PLOS ONE 6263:31570648 6214:32129504 6165:32343335 6124:33464342 6083:31684681 6034:29377409 5985:19195413 5977:16831112 5937:17156479 5886:37230961 5877:10207863 5834:18488428 5783:32512768 5724:33843549 5683:25267685 5675:18605812 5634:21 March 5601:27043678 5571:Medicine 5552:30883669 5503:18199864 5462:35045113 5430:PLOS Med 5411:35918097 5359:32101579 5319:PLOS ONE 5295:29477251 5230:Archived 5218:29677603 5159:35858125 5151:19185342 5103:(2023). 5080:ClinCalc 5054:Archived 5050:ClinCalc 5021:Archived 4981:Archived 4949:Archived 4907:Archived 4874:35068363 4826:Archived 4780:28965364 4720:24484978 4670:10 April 4661:Archived 4649:33977870 4590:Archived 4578:33354752 4536:28135844 4492:21872337 4452:24362450 4414:15705013 4338:22436728 4330:28850959 4295:16848671 4257:18370448 4217:27591914 4165:27141292 4033:27255113 3973:Archived 3938:Archived 3908:Archived 3904:DailyMed 3875:Archived 3871:DailyMed 3845:Archived 3841:DailyMed 3798:Archived 3768:Archived 3736:Archived 3710:3 August 3704:Archived 3670:Archived 3623:16027765 3561:31124380 3475:Archived 3441:See also 3429:Research 3341:seizures 3169:compound 3159:racemize 2960:cytokine 2893:receptor 2875:affinity 2824:dopamine 2668:α/β/δ/γ- 2241:Species 2215:no data 2212:no data 2209:no data 2190:no data 2187:no data 2159:no data 2156:no data 2129:no data 2099:no data 2076:no data 2053:no data 1981:relative 1771:such as 1769:inducers 1757:diazepam 1695:Overdose 1674:insomnia 1628:glaucoma 1541:epilepsy 1446:(POTS). 1373:orlistat 1126:dopamine 1103:overdose 1091:seizures 1071:insomnia 1044:by mouth 993:(verify) 715:DrugBank 371:Class C1 313:ATC code 272: B2 259:category 241:DailyMed 27098:Geritol 27094:Flonase 27070:Centrum 27060:Biotene 27042:Actifed 27016:Twinrix 27006:Rotarix 26966:Hiberix 26946:Fluarix 26926:Bexsero 26884:Tagamet 26844:Avandia 26815:Current 26682:Current 26621:UWA-101 26586:PRO-LAD 26516:ETH-LAD 26277:Epinine 26233:a-Me-DA 26156:4-MePPP 26151:4-MePHP 26146:4-MePBP 26058:Ariadne 25836:Others: 25746:3,4-DCA 25743:Others: 25694:2,3-MDA 25679:6-MAPDB 25644:5-MAPDB 25325:Cathine 25249:ZDCM-04 25234:Psi-DOM 25219:Ganesha 25085:Others: 24900:2C-T-33 24895:2C-T-32 24890:2C-T-31 24885:2C-T-30 24880:2C-T-28 24875:2C-T-27 24870:2C-T-25 24865:2C-T-24 24860:2C-T-23 24850:2C-T-22 24845:2C-T-21 24840:2C-T-20 24835:2C-T-19 24830:2C-T-18 24825:2C-T-17 24820:2C-T-16 24815:2C-T-15 24810:2C-T-14 24805:2C-T-13 24800:2C-T-12 24795:2C-T-11 24790:2C-T-10 24605:2C-B-AN 24323:UMB-116 24318:UMB-103 24313:UMB-101 24308:UMB-100 24099:MIN-101 24089:CT-1812 24079:BD-1067 24074:BD-1008 23981:BD-1047 23917:Saffron 23902:RHL-033 23672:Dup-734 23657:BD-1067 23652:BD-1063 23647:BD-1060 23642:BD-1047 23637:BD-1031 23632:BD-1008 23577:PRE-084 23394:Cocaine 23359:BD-1052 23168:(e.g., 23154:(e.g., 23108:(e.g., 23090:(e.g., 23068:(e.g., 23051:SLV-314 23046:SLV-313 22939:(e.g., 22927:DR-4485 22866:(e.g., 22833:(e.g., 22823:(e.g., 22783:(e.g., 22776:E-55888 22726:(e.g., 22704:(e.g., 22679:(e.g., 22667:doxepin 22657:(e.g., 22643:(e.g., 22526:AVN-397 22521:AVN-322 22516:AVN-211 22511:AVN-101 22475:(e.g., 22468:ABT-354 22437:ST-1936 22391:(e.g., 22343:(e.g., 22306:(e.g., 22292:(e.g., 22236:(e.g., 22213:(e.g., 21998:(e.g., 21949:(e.g., 21939:(e.g., 21922:Thujone 21906:(e.g., 21793:(e.g., 21786:AS-8112 21745:toluene 21735:(e.g., 21717:(e.g., 21679:(e.g., 21653:butanol 21651:(e.g., 21588:(e.g., 21541:(e.g., 21527:(e.g., 21510:TIK-301 21482:(e.g., 21435:S-14671 21324:(e.g., 21226:(e.g., 21188:WAY-629 21139:(e.g., 21088:(e.g., 21074:(e.g., 21027:(e.g., 20997:LSD-Pip 20959:(e.g., 20937:(e.g., 20878:(e.g., 20844:2C-T-21 20822:(e.g., 20785:(e.g., 20762:TIK-301 20754:(e.g., 20731:(e.g., 20596:(e.g., 20528:(e.g., 20458:(e.g., 20433:(e.g., 20411:(e.g., 20372:(e.g., 20350:(e.g., 20315:(e.g., 20264:(e.g., 20176:(e.g., 20166:(e.g., 20136:(e.g., 20082:(e.g., 20070:S-14671 19970:KML-010 19913:(e.g., 19781:(e.g., 19754:(e.g., 19672:(e.g., 19639:(e.g., 19625:(e.g., 19568:(e.g., 19524:LSD-Pip 19478:(e.g., 19451:(e.g., 19392:(e.g., 19359:2CB-Ind 19348:2C-T-21 19326:(e.g., 19282:25I-NBF 19209:(e.g., 19191:(e.g., 19155:(e.g., 19101:(e.g., 19064:(e.g., 19054:(e.g., 19039:(e.g., 18989:(e.g., 18903:(e.g., 18847:(e.g., 18805:(e.g., 18735:(e.g., 18675:(e.g., 18614:(e.g., 18575:(e.g., 18532:(e.g., 18501:(e.g., 18456:(e.g., 18384:(e.g., 18311:S-15535 18301:NAN-190 18248:(e.g., 18183:(e.g., 18160:(e.g., 18077:(e.g., 18050:S-15535 18045:S-14671 17985:MKC-242 17935:F-15063 17930:F-14679 17925:F-13714 17920:F-12826 17875:(e.g., 17804:(e.g., 17766:(e.g., 17732:(e.g., 17556:Choline 17116:BW-A444 17094:(e.g., 17087:BNC-210 17075:(e.g., 17038:ABT-126 17022:(e.g., 16981:XY-4083 16946:TC-6683 16941:TC-5619 16936:TC-5214 16931:TC-2216 16926:TC-1827 16921:TC-1734 16916:TC-1698 16826:NS-1738 16820:tobacco 16706:Choline 16651:ABT-894 16646:ABT-560 16641:ABT-418 16636:ABT-202 16391:GZ-793A 16335:(e.g., 16273:(e.g., 16271:Opioids 16192:(e.g., 16178:(e.g., 16144:(e.g., 16132:A-80426 16129:Others: 16091:Doxepin 16044:cocaine 16042:(e.g., 15990:NS-2359 15985:Nefopam 15940:HDMP-28 15930:EXP-561 15890:Cocaine 15819:McN5652 15698:RTI-353 15528:(e.g., 15526:Opioids 15487:(e.g., 15473:(e.g., 15451:(e.g., 15446:Others: 15367:Doxepin 15320:cocaine 15318:(e.g., 15266:NS-2359 15261:Nefopam 15216:HDMP-28 15206:EXP-561 15166:Cocaine 15090:McN5652 15009:LR-5182 14771:NS-2359 14761:Nefopam 14721:LR-5182 14666:EXP-561 14541:Others: 14493:RTI-336 14488:RTI-229 14483:RTI-177 14478:RTI-150 14473:RTI-126 14468:RTI-121 14463:RTI-113 14458:RTI-112 14418:Cocaine 14316:HDMP-28 14235:DBL-583 14132:Yohimbe 14100:cocaine 14094:(e.g., 14009:Afrodor 13979:(e.g., 13957:(e.g., 13939:(e.g., 13879:Icariin 13846:PL-6983 13445:AMG 133 13234:Yohimbe 13210:Ephedra 13097:Ephedra 13052:Cathine 12807:Opioids 12402:Lithium 11970:Doxepin 11502:and/or 11399:1918431 11302:9 April 11138:1310940 10819:. U.S. 10745:. U.S. 10640:. U.S. 10292:Bibcode 10260:3724447 10220:7768026 10060:PubChem 10039:8240925 9969:3107223 9836:1813908 9601:4310912 9466:4314873 9299:4820462 9282:: 148. 9130:8559442 9033:4135078 8871:9537821 8836:7855217 8801:3816971 8766:6086881 8732:PubChem 8698:Liu T. 8662:Roth BL 8636:5148637 8587:6978693 8547:1577336 8408:2895766 8307:6465131 8009:8830063 7919:3550116 7845:6637660 7791:. U.S. 7762:4112250 7686:7002596 7558:6490529 7157:7025781 7016:1599716 6894:2797110 6729:9886814 6639:5960024 6590:5900810 6501:1663570 6449:3229037 6362:6109107 6313:7577505 6290:Bibcode 6254:7067282 6205:7059898 6074:6816175 6025:5947828 5928:1764891 5911:: 300. 5825:2528204 5774:7345023 5592:4998539 5543:6422318 5453:8769343 5402:9344377 5350:7043778 5327:Bibcode 5286:5889788 5226:5011570 4913:29 July 4903:PubChem 4771:6485546 4208:5540329 4156:4837968 4024:4959100 3944:7 March 3614:1163271 3354:generic 3311:History 3139:racemic 3058:erythro 3030:CYP2C19 2939:of the 2937:agonist 2896:agonist 2801:prodrug 2795:erythro 2490:Rodent 1961:Erythro 1941:Hydroxy 1929:Hydroxy 1917: 1890:alcohol 1870:seizure 1670:anxiety 1609:Seizure 1411:, like 1264:craving 1194:placebo 1075:anxiety 1055:placebo 1049:Common 880:Formula 724:DB01156 670:PubChem 445:Unknown 412:Rx-only 409:WARNING 381:: 329:) 323: ( 321:N06AX12 243:: 219:a695033 130:-pee-on 27392:Portal 27161:People 27138:Ribena 27035:Former 26986:Menveo 26981:Kinrix 26956:Havrix 26921:Arexvy 26899:Zantac 26854:Boniva 26829:Advair 26822:Pharma 26724:Haleon 26719:Former 26704:Tesaro 26536:IP-LAD 26456:AL-LAD 26228:6-OHDA 25763:(also 25756:DiFMDA 25674:6-MAPB 25664:6-EAPB 25654:6-APDB 25639:5-MAPB 25629:5-EAPB 25624:5-APDB 25229:MMDA-2 25129:3C-MAL 25081:MDMPEA 24932:DESOXY 24910:2C-TFM 24905:2C-TFE 24785:2C-T-9 24780:2C-T-8 24775:2C-T-7 24770:2C-T-6 24765:2C-T-5 24760:2C-T-4 24755:2C-T-3 24750:2C-T-2 24725:2C-O-4 24715:2C-NH2 24690:2C-G-N 24685:2C-G-6 24680:2C-G-5 24675:2C-G-4 24670:2C-G-3 24665:2C-G-2 24660:2C-G-1 24338:YZ-185 24333:YZ-069 24328:YZ-011 24219:UMB-82 24214:UMB-23 24094:LR-172 24084:CM-156 24069:AC-927 23986:BD1063 23947:YKP10A 23912:RTI-55 23799:4-IPBS 23789:4C-T-2 23707:NE-100 23702:MS-377 23697:LR-172 23692:LR-132 23677:E-5842 23667:CM-156 23627:AC-927 23612:UMB-82 23607:UMB-23 23354:BD-737 23329:4-PPBP 22801:LP-211 22591:MS-245 22417:E-6837 22413:E-6801 21667:m-CPBG 21198:YM-348 21047:MK-212 20961:ALD-52 20840:2C-T-7 20836:2C-T-2 19665:TFMFly 19588:O-4310 19484:ALD-52 19480:1P-LSD 19444:DMBMPP 19344:2C-T-7 19340:2C-T-2 18341:UH-301 18281:Mefway 17146:Curare 17063:AQW051 17010:18-MAC 16966:UB-165 16776:GTS-21 16606:5-HIAA 16574:nAChRs 16445:Others 16000:PRC200 15945:HP-505 15688:PIM-35 15276:PRC200 15221:HP-505 15029:O-2172 14776:O-2172 14453:RTI-55 14002:Others 13689:WHO-EM 13618:Others 13540:5-HT2C 13517:DACRAs 12527:WHO-EM 12240:Mixed: 12097:Others 11781:Others 11689:NaSSAs 11438: 11397: 11362: 11325: 11270: 11234:Гарант 11214: 11206: 11171: 11136: 11128: 11064: 11037: 11029: 10757:3 July 10392:27 May 10267: 10257: 10218: 10177: 10169: 10119: 10037: 10002: 9967: 9929: 9891: 9881: 9834: 9807: 9769: 9732: 9690: 9682: 9644: 9608: 9598: 9559: 9551: 9516: 9508: 9473: 9463: 9432: 9424: 9376: 9341: 9306: 9296: 9255: 9215: 9177: 9137: 9127: 9083: 9075: 9040: 9030: 8991: 8940: 8904: 8869: 8834: 8799: 8764: 8643: 8633: 8594: 8584: 8545: 8537: 8498: 8463: 8455: 8415: 8405: 8357: 8349: 8314: 8304: 8265: 8230: 8195: 8187: 8138: 8130: 8089: 8007: 7972: 7926: 7916: 7875: 7852: 7842: 7803:13 May 7769: 7759: 7720: 7693: 7683: 7644: 7636: 7601: 7565: 7555: 7516: 7508: 7461: 7453: 7414: 7406: 7303: 7268: 7233: 7164: 7154: 7115: 7064: 7023: 7013: 6999:: 24. 6972: 6936: 6901: 6891: 6788: 6744: 6736: 6726: 6687: 6646: 6636: 6597: 6587: 6548: 6541:514842 6538: 6499: 6491: 6456: 6446: 6404: 6369: 6359: 6320: 6310: 6261: 6251: 6212: 6202: 6163: 6122: 6081: 6071: 6059:(10). 6032: 6022: 5983: 5975: 5935: 5925: 5884: 5874: 5832: 5822: 5781: 5771: 5730: 5722: 5681: 5673: 5599: 5589: 5550: 5540: 5501: 5460: 5450: 5409: 5399: 5357: 5347: 5293: 5283: 5265:Lancet 5224: 5216: 5157: 5149: 5131:Lancet 4987:2 June 4955:5 June 4941: 4880: 4872: 4820: 4810: 4778: 4768: 4718: 4708: 4655: 4647: 4596:17 May 4584: 4576: 4534: 4490: 4450: 4412: 4336: 4328: 4293: 4263: 4255: 4215: 4205: 4163: 4153: 4089: 4031: 4021: 3621: 3611: 3567: 3559: 3225:, and 3210:salt. 3189: 3046:AKR7A3 3042:AKR7A2 3021:- and 3013:CYP2B6 2925: 2859: 2847: 2834:, and 2792:, and 2748:, GABA 2728:, 5-HT 2722: 2714:Notes: 2708:Human 2684:Human 2662:Human 2636:Human 2606:Human 2597:12,000 2576:Human 2546:Human 2516:Human 2468:Human 2446:Human 2420:Human 2364:15,600 1861:, and 1812:CYP2D6 1799:, and 1791:, and 1763:, and 1737:CYP2B6 1529: 1527:mg/105 1525: 1517: 1513: 1501: 1497: 1492: 1488: 1484: 1469:tablet 1419:, and 1417:abulia 1413:apathy 1161: 1081:, and 1079:tremor 1063:nausea 1027:add-on 948:SMILES 915:239.74 823:ChEMBL 792:D00817 784:D07591 592: 588: 584: 567: 563: 557: 553: 547: 543: 537: 533: 518:Others 516: 508: 500: 492: 478:CYP2B6 406: 393: 383:℞-only 369: 356: 239: 143: 136:am-fa- 27335:Other 27239:Other 27046:Advil 26764:Glaxo 26711:(85%) 26571:MT-45 26324:-DOPS 26315:-DOPA 26256:-DOPA 26223:6-FNE 26166:MOPVP 26161:MOPPP 26136:MDPPP 26131:MDPBP 26126:α-PVP 26121:α-PPP 26116:α-PHP 26111:α-PBP 26053:4-MAB 26048:4-CAB 26002:3-MMC 25900:4-MPD 25890:4-MEC 25885:4-FMC 25880:4-EMC 25875:4-CMC 25870:4-BMC 25860:3-FMC 25832:MDMPH 25729:MMDMA 25709:MDHMA 25649:6-APB 25619:5-APB 25614:4-MTA 25609:4-MMA 25599:4-FMA 25271:3-FMA 25261:2-FMA 25214:DOTFM 25169:DMMDA 25164:DMCPA 25139:Aleph 25119:3C-BZ 25114:3C-AL 25093:DMPEA 25076:MDPEA 24987:TCB-2 24957:MEPEA 24915:2C-YN 24740:2C-SE 24735:2C-Ph 24705:2C-iP 24645:2C-EF 24630:2C-CP 24625:2C-CN 24615:2C-Bu 24610:2C-Bn 24303:SM-21 24044:PB-28 23971:3-PPP 23794:4-IBP 23622:3-PPP 23324:3-PPP 22796:LP-44 22791:LP-12 22766:AS-19 22038:BIMU8 21959:xenon 21106:TFMPP 20435:TFMPP 19660:TCB-2 19649:TFMPP 19613:RH-34 18525:TFMPP 18176:AV965 17995:NBUMP 17534:(and 17516:Xenon 17015:18-MC 16994:(and 16590:(and 16316:VMATs 14528:WF-33 14523:WF-31 14518:WF-23 14513:WF-11 13675:Water 13550:5-HTP 13425:GLP-1 13244:Other 12497:5-HTP 12061:TeCAs 11722:SARIs 11656:NDRIs 11575:SNRIs 11517:SSRIs 11212:S2CID 11134:S2CID 11035:S2CID 10924:(PDF) 10913:(PDF) 10791:(PDF) 10776:(PDF) 10727:5 May 10717:(FDA) 10713:U.S. 10693:9 May 10494:(PDF) 10487:(FDA) 10483:U.S. 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