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90:
63:. Most utopioid derivatives are however selective kappa agonists, which may have limited abuse potential as dissociative hallucinogens, but do not alleviate withdrawal distress in opioid dependent individuals or maintain addiction in a typical sense. Nevertheless, this has not stopped them from being sold as designer drugs, and a number of these compounds are now banned in many jurisdictions alongside U-47700 itself.
323:
50:
and became widely sold around the world for several years before being banned in various jurisdictions from 2016 onwards. Following the prohibition of U-47700, a number of related compounds have continued to appear on illicit drug markets. They are often marketed online or included as components in
914:
Vandeputte MM, Persson M, Walther D, Vikingsson S, Kronstrand R, Baumann MH, Gréen H, Stove CP (March 2022). "Characterization of recent non-fentanyl synthetic opioids via three different in vitro µ-opioid receptor activation assays".
960:"Investigation of the μ- and κ-opioid receptor activation by eight new synthetic opioids using the [35 S]-GTPγS assay: U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520, and U-48800"
59:
and N-Ethyl-U-47700 retain similar mu selectivity but with lower potency similar to that of morphine, or have a mixture of mu and kappa mediated effects, such as
51:
mixtures sold under the guise of "street heroin." U-47700 itself is the most potent mu opioid agonist from this class, around 7-10x the potency of
1115:
773:"The search for the "next" euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning"
1076:
Cheney BV. Structure-activity relationships for drugs binding to the agonist and antagonist states of the primary morphine receptor.
34:. However, they were never marketed for medical use. Some compounds from this class have been used for scientific research as model
1030:"In vitro μ-opioid receptor activation potential of U10 and β-U10, positional isomers of the synthetic opioid naphthyl U-47700"
1007:
1120:
681:
686:
1125:
1110:
865:"U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market"
820:
Kyei-Baffour K, Lindsley CW (December 2020). "DARK Classics in
Chemical Neuroscience: U-47700".
1130:
35:
1008:"Non-fentanyl opioids and related new psychoactive substances with no known legitimate uses"
8:
1059:
989:
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891:
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118:
98:
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886:
876:
863:
Baumann MH, Tocco G, Papsun DM, Mohr AL, Fogarty MF, Krotulski AJ (November 2020).
829:
792:
784:
737:
311:
505:
289:
833:
599:
579:
390:
56:
726:"Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review"
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485:
344:
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788:
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881:
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47:
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27:
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89:
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52:
913:
328:
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60:
43:
30:
drugs first developed in the 1970s by the pharmaceutical company
31:
24:
771:
Sharma KK, Hales TG, Rao VJ, NicDaeid N, McKenzie C (2019).
957:
723:
322:
958:
Otte L, Wilde M, Auwärter V, Grafinger KE (July 2022).
724:
Armenian P, Vo KT, Barr-Walker J, Lynch KL (May 2018).
862:
770:
819:
1102:
1027:
1021:
951:
907:
856:
813:
764:
717:
1045:
975:
890:
880:
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1116:Chemical classes of psychoactive drugs
1103:
711:Cayman Chemical News and Announcements
1028:Vandeputte MM, Stove CP (July 2023).
1015:International Narcotics Control Board
66:
42:selective compound from this class,
13:
14:
1142:
742:10.1016/j.neuropharm.2017.10.016
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38:agonists. In the mid-2010s, one
1070:
55:. Some other compounds such as
1000:
699:
1:
692:
682:List of benzimidazole opioids
834:10.1021/acschemneuro.0c00330
7:
675:
23:) are a class of synthetic
10:
1147:
929:10.1007/s00204-021-03207-9
687:List of fentanyl analogues
432:3,4-Ethylenedioxy-U-51574
412:3,4-Ethylenedioxy-U-47700
1080:. 1988 Mar;31(3):521-31.
1034:Drug Testing and Analysis
964:Drug Testing and Analysis
822:ACS Chemical Neuroscience
789:10.1007/s11419-018-0454-5
882:10.3390/brainsci10110895
370:N,N-Didesmethyl-U-47700
1121:Dimethylamino compounds
917:Archives of Toxicology
511:N-Cyclopropyl-U-47700
621:4-TFM-U-48520 (U-04)
605:2,4-Difluoro-U-48800
585:3,4-Difluoro-U-47700
36:kappa opioid receptor
569:3,4-Dibromo-U-47700
491:N-Isopropyl-U-47700
350:N-Desmethyl-U-47700
1086:10.1021/jm00398a007
777:Forensic Toxicology
74:Chemical structure
1017:. 28 January 2022.
549:N-Methyl-U-47931E
530:N-Methoxy-U-47700
67:Table of Utopioids
46:, re-emerged as a
40:mu opioid receptor
828:(23): 3928–3936.
736:(Pt A): 121–132.
730:Neuropharmacology
673:
672:
471:N-Propyl-U-47700
1138:
1126:Cyclohexylamines
1095:
1074:
1068:
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1047:10.1002/dta.3554
1025:
1019:
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1004:
998:
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979:
977:10.1002/dta.3238
970:(7): 1187–1199.
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452:N-Ethyl-U-47700
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713:. 12 July 2018.
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391:3,4-MDO-U-47700
69:
57:3,4-MDO-U-47700
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1111:Lists of drugs
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1040:(3): 323–326.
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869:Brain Sciences
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21:U-type opioids
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649:2417942-61-9
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499:2748319-16-4
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479:2749433-76-7
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440:2748623-91-6
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420:2749619-08-5
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400:2488874-96-8
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48:designer drug
45:
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26:
22:
18:
1131:Carboxamides
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733:
729:
719:
710:
701:
338:119878-31-8
20:
16:
15:
875:(11): 895.
783:(1): 1–16.
707:"Utopioids"
669:67579-80-0
629:67579-38-8
557:75570-38-6
358:67579-73-1
316:96744-75-1
294:87151-85-7
284:Spiradoline
251:67198-13-4
229:98587-47-4
209:67579-76-4
167:67579-11-7
137:Bromadoline
123:82657-23-6
103:67579-13-9
83:CAS number
1105:Categories
1078:J Med Chem
693:References
135:U-47931E (
77:Drug name
1064:260101432
994:246701889
945:246239574
850:220438986
645:165362154
589:165362347
534:155907659
515:165361451
495:137700166
475:137700434
456:155907846
436:137700374
416:137700298
396:139598237
374:129406364
354:129390993
334:117071705
282:U-62066 (
221:U-50211
205:129392412
185:137700072
28:analgesic
17:Utopioids
1056:37482925
986:35142070
937:35072756
901:33238449
842:32639714
807:30636980
758:21404877
750:29042317
676:See also
665:54524276
625:53720446
553:54482637
267:44269303
263:U-51574
225:13544017
201:U-49900
163:13544026
159:U-48520
119:13544016
115:U-47700
99:44269286
95:U-47109
80:PubChem
53:morphine
1093:2831361
892:7700279
798:6314991
329:U-77891
307:U-69593
247:3036289
242:U-50488
180:U-48800
143:6328449
61:U-48800
44:U-47700
1091:
1062:
1054:
992:
984:
943:
935:
899:
889:
848:
840:
805:
795:
756:
748:
661:β-U10
641:α-U10
312:105104
32:Upjohn
25:opioid
1060:S2CID
1011:(PDF)
990:S2CID
941:S2CID
846:S2CID
754:S2CID
290:55652
1089:PMID
1052:PMID
982:PMID
933:PMID
897:PMID
838:PMID
803:PMID
746:PMID
1082:doi
1042:doi
972:doi
925:doi
887:PMC
877:doi
830:doi
793:PMC
785:doi
738:doi
734:134
1107::
1058:.
1050:.
1038:16
1036:.
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988:.
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966:.
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19:(
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