126:
216:
34:
166:
231:. The oxygen atom at the 11 position in this steroid is an absolute requirement for biological activity. There are however no known natural sources for starting materials that contain that feature. The only method for preparing this drug prior to 1952 was a lengthy synthesis starting from
614:
307:
In 2015, Pfizer resurrected the Upjohn name for a division which manufactures and licenses drugs for which patents have expired; as of 2019, it planned to divest itself of this business in 2020.
681:
235:
isolated from bile. In 1952, two Upjohn biochemists, Dury
Peterson and Herb Murray announced that they were able to introduce this crucial oxygen atom by fermentation of the steroid
1488:
674:
1483:
690:
667:
1478:
427:
1172:
1162:
1152:
1142:
1132:
1122:
1112:
1102:
1092:
352:
152:, which were specifically designed to be easily digested. They could be "reduced to a powder under the thumb", a strong marketing argument at the time.
1473:
331:
595:
509:
243:. Over the next several years a group of chemists headed by John Hogg developed a process for preparing cortisone from the soybean sterol
1463:
1458:
1468:
542:
269:
by V. VanRheenen, R. C. Kelly, and D. Y. Cha in 1976. Upjohn's best known drugs before the acquisition by Pfizer were
202:
1437:
1498:
570:
1305:
844:
527:
445:
384:
Hogg, John A. (1992). "Steroids, the steroid community, and Upjohn in perspective: A profile of innovation".
370:
1063:
1420:
874:
176:
869:
1043:
1013:
998:
926:
911:
849:
794:
1375:
1310:
1018:
759:
1225:
946:
936:
931:
789:
729:
547:
184:
44:
20:
659:
1330:
1300:
1250:
1205:
1053:
744:
266:
145:
1405:
1210:
1028:
993:
839:
819:
654:
459:
297:
102:
92:
1365:
1340:
1290:
1285:
1265:
1215:
1148:
1138:
1008:
983:
891:
886:
854:
784:
754:
8:
1390:
1355:
1345:
1270:
1255:
978:
973:
714:
704:
314:. The merger was expected to close in the first half of 2020, but was delayed due to the
1315:
1128:
1098:
1048:
814:
799:
409:
137:
494:
1295:
1260:
749:
521:
481:
oxidation of olefins to cis-1,2-glycols using tertiary amine oxides as the oxidant".
439:
401:
397:
364:
315:
141:
116:
413:
1023:
961:
941:
896:
881:
824:
490:
393:
1493:
1370:
1280:
1275:
916:
864:
834:
1200:
906:
1452:
1380:
1178:
1080:
988:
543:"Pfizer Is Spinning Off Upjohn. What's Left Will Be No Bargain, Analyst Says"
1158:
244:
236:
220:
125:
405:
318:. The merger was completed in November 2020 and the new company was named
1350:
1033:
901:
477:
Vanrheenen, V.; Kelly, R.C.; Cha, D.Y. (1976). "An improved catalytic OsO
251:
232:
1410:
1038:
769:
282:
270:
258:
1360:
1230:
1003:
968:
829:
804:
293:
286:
278:
274:
262:
228:
136:
was an
American pharmaceutical manufacturing firm founded in 1886 in
88:
571:"Viagra and EpiPen drugmakers form a $ 20-billion-a-year powerhouse"
1240:
1235:
1118:
1108:
779:
240:
1395:
1245:
1168:
1088:
1058:
956:
921:
859:
774:
734:
719:
689:
319:
255:
247:. The microbiological oxygenation is a key step in this process.
106:
215:
1335:
1325:
1220:
951:
764:
709:
301:
33:
1415:
1385:
1320:
809:
739:
724:
311:
227:
Upjohn developed a process for the large scale production of
1195:
129:
Logo of Upjohn Pill & Granule, later The Upjohn
Company
655:
http://www.michmarkers.com/startup.asp?startpage=S0582.htm
596:"Mylan delays merger with Upjohn due to COVID-19 pandemic"
310:
In July 2019, Pfizer announced plans to merge Upjohn with
148:
medical school. The company was originally formed to make
649:
254:
biochemically converted cortisone into the more potent
353:"William E. Upjohn: Person of the Century 1853 - 1932"
16:
American pharmaceutical manufacturing firm (1886–1995)
1489:
Defunct pharmaceutical companies of the United States
615:"Mylan completes merger with Upjohn to form Viatris"
359:. Archived from the original on September 28, 2007.
476:
265:, the company is known for the development of the
434:. Archived from the original on January 11, 2012.
350:
1450:
1484:Pharmaceutical companies disestablished in 1995
351:Lohrstorfer, Martha; Larson, Catherine (2002).
179:for grammar, style, cohesion, tone, or spelling
332:W. E. Upjohn Institute for Employment Research
691:Pharmaceutical companies of the United States
675:
1479:Pharmaceutical companies established in 1886
1079:
540:
516:. Archived from the original on May 7, 2006.
682:
668:
32:
541:Nathan-Kazis, Josh (September 19, 2019).
460:"DailyMed - DELTASONE- prednisone tablet"
428:"Prednisone Half Life Is A Good Medicine"
203:Learn how and when to remove this message
612:
568:
214:
124:
613:Sabatini, Patricia (16 November 2020).
1474:Companies based in Kalamazoo, Michigan
1451:
663:
593:
383:
159:
250:Subsequently, Upjohn together with
13:
1464:1995 disestablishments in Michigan
969:Pharmaceutical Product Development
14:
1510:
643:
569:Valinsky, Jordan (29 July 2019).
239:with a common mold of the genus
1438:List of pharmaceutical companies
261:by a bacterial fermentation. In
164:
144:who was an 1875 graduate of the
1459:1886 establishments in Michigan
606:
650:Memories of The Upjohn Company
587:
562:
534:
502:
470:
452:
420:
377:
344:
1:
1469:1995 mergers and acquisitions
845:Institute for OneWorld Health
594:Gough, Paul (26 March 2020).
495:10.1016/S0040-4039(00)78093-2
337:
1064:West Pharmaceutical Services
398:10.1016/0039-128X(92)90013-Y
292:In 1995, Upjohn merged with
7:
637:Upjohn Co. v. United States
325:
300:; the company was owned by
71:; 29 years ago
10:
1515:
870:McNeil Consumer Healthcare
155:
18:
1433:
1376:Smith, Kline & French
1188:
1072:
927:Northwest Biotherapeutics
912:Merrimack Pharmaceuticals
697:
600:Pittsburgh Business Times
526:: CS1 maint: unfit URL (
444:: CS1 maint: unfit URL (
432:PrednisoneSideEffects.org
369:: CS1 maint: unfit URL (
112:
98:
83:
65:
50:
40:
31:
357:Kalamazoo Public Library
619:Pittsburgh Post-Gazette
21:Upjohn (disambiguation)
1499:Life sciences industry
1301:Leiner Health Products
745:Amneal Pharmaceuticals
304:from 2002 until 2020.
298:Pharmacia & Upjohn
267:Upjohn dihydroxylation
224:
146:University of Michigan
130:
103:Pharmacia & Upjohn
93:Pharmacia & Upjohn
855:Johnson & Johnson
639:(449 U.S. 383) (1981)
218:
128:
1149:Jazz Pharmaceuticals
1139:Horizon Therapeutics
1009:Sarepta Therapeutics
984:Proteon Therapeutics
979:Procter & Gamble
892:Melinta Therapeutics
785:Bristol Myers Squibb
464:dailymed.nlm.nih.gov
19:For other uses, see
1356:Repros Therapeutics
1271:Forest Laboratories
1256:Cutter Laboratories
974:Prasco Laboratories
715:Acorda Therapeutics
705:Abbott Laboratories
514:Resource Informagen
483:Tetrahedron Letters
223:produced by Upjohn.
28:
1316:Miles Laboratories
1306:Martek Biosciences
1129:Endo International
1049:Ventria Bioscience
815:Danco Laboratories
225:
183:You can assist by
138:Hastings, Michigan
134:The Upjohn Company
131:
27:The Upjohn Company
26:
1446:
1445:
1429:
1428:
1261:DNAPrint Genomics
750:Avax Technologies
316:COVID-19 pandemic
263:chemical research
213:
212:
205:
142:William E. Upjohn
123:
122:
1506:
1077:
1076:
1024:Tec Laboratories
897:Melior Discovery
882:Kinetic Concepts
825:Galena Biopharma
684:
677:
670:
661:
660:
629:
628:
626:
625:
610:
604:
603:
591:
585:
584:
582:
581:
566:
560:
559:
557:
555:
538:
532:
531:
525:
517:
510:"Upjohn Company"
506:
500:
498:
474:
468:
467:
456:
450:
449:
443:
435:
424:
418:
417:
381:
375:
374:
368:
360:
348:
208:
201:
197:
194:
188:
168:
167:
160:
79:
77:
72:
61:
59:
36:
29:
25:
1514:
1513:
1509:
1508:
1507:
1505:
1504:
1503:
1449:
1448:
1447:
1442:
1425:
1371:Schering-Plough
1281:ImClone Systems
1184:
1068:
917:Myriad Genetics
907:Merck & Co.
865:Janssen Biotech
835:Gilead Sciences
693:
688:
646:
633:
632:
623:
621:
611:
607:
592:
588:
579:
577:
567:
563:
553:
551:
539:
535:
519:
518:
508:
507:
503:
480:
475:
471:
458:
457:
453:
437:
436:
426:
425:
421:
392:(12): 593–616.
382:
378:
362:
361:
349:
345:
340:
328:
209:
198:
192:
189:
182:
169:
165:
158:
105:
75:
73:
70:
57:
55:
24:
17:
12:
11:
5:
1512:
1502:
1501:
1496:
1491:
1486:
1481:
1476:
1471:
1466:
1461:
1444:
1443:
1441:
1440:
1434:
1431:
1430:
1427:
1426:
1424:
1423:
1418:
1413:
1408:
1403:
1398:
1393:
1388:
1383:
1378:
1373:
1368:
1363:
1358:
1353:
1348:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1201:Allergan, Inc.
1198:
1192:
1190:
1186:
1185:
1183:
1182:
1181:(Canada, 2010)
1176:
1166:
1156:
1146:
1136:
1126:
1116:
1106:
1096:
1085:
1083:
1074:
1070:
1069:
1067:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
965:
964:
959:
949:
944:
939:
934:
932:Norwich Pharma
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
878:
877:
872:
867:
862:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
701:
699:
695:
694:
687:
686:
679:
672:
664:
658:
657:
652:
645:
644:External links
642:
641:
640:
631:
630:
605:
586:
561:
533:
501:
489:(23): 1973–6.
478:
469:
451:
419:
376:
342:
341:
339:
336:
335:
334:
327:
324:
211:
210:
172:
170:
163:
157:
154:
121:
120:
114:
110:
109:
100:
96:
95:
85:
81:
80:
67:
63:
62:
52:
48:
47:
45:Pharmaceutical
42:
38:
37:
15:
9:
6:
4:
3:
2:
1511:
1500:
1497:
1495:
1492:
1490:
1487:
1485:
1482:
1480:
1477:
1475:
1472:
1470:
1467:
1465:
1462:
1460:
1457:
1456:
1454:
1439:
1436:
1435:
1432:
1422:
1419:
1417:
1414:
1412:
1409:
1407:
1404:
1402:
1399:
1397:
1394:
1392:
1389:
1387:
1384:
1382:
1381:Sterling Drug
1379:
1377:
1374:
1372:
1369:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1337:
1334:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1282:
1279:
1277:
1274:
1272:
1269:
1267:
1264:
1262:
1259:
1257:
1254:
1252:
1249:
1247:
1244:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1193:
1191:
1187:
1180:
1179:Bausch Health
1177:
1174:
1170:
1167:
1164:
1160:
1157:
1154:
1150:
1147:
1144:
1140:
1137:
1134:
1130:
1127:
1124:
1120:
1117:
1114:
1110:
1107:
1104:
1100:
1097:
1094:
1090:
1087:
1086:
1084:
1082:
1081:Tax inversion
1078:
1075:
1071:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
990:
989:Purdue Pharma
987:
985:
982:
980:
977:
975:
972:
970:
967:
963:
960:
958:
955:
954:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
876:
873:
871:
868:
866:
863:
861:
858:
857:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
702:
700:
696:
692:
685:
680:
678:
673:
671:
666:
665:
662:
656:
653:
651:
648:
647:
638:
635:
634:
620:
616:
609:
601:
597:
590:
576:
572:
565:
550:
549:
544:
537:
529:
523:
515:
511:
505:
496:
492:
488:
484:
473:
465:
461:
455:
447:
441:
433:
429:
423:
415:
411:
407:
403:
399:
395:
391:
387:
380:
372:
366:
358:
354:
347:
343:
333:
330:
329:
323:
321:
317:
313:
308:
305:
303:
299:
295:
290:
288:
284:
280:
276:
272:
268:
264:
260:
257:
253:
248:
246:
242:
238:
234:
230:
222:
217:
207:
204:
196:
186:
180:
178:
173:This section
171:
162:
161:
153:
151:
150:friable pills
147:
143:
139:
135:
127:
118:
115:
111:
108:
104:
101:
97:
94:
90:
86:
82:
68:
64:
53:
49:
46:
43:
39:
35:
30:
22:
1400:
1159:Mallinckrodt
1044:Upsher-Smith
875:Ortho-McNeil
636:
622:. Retrieved
618:
608:
599:
589:
578:. Retrieved
574:
564:
552:. Retrieved
546:
536:
513:
504:
486:
482:
472:
463:
454:
431:
422:
389:
385:
379:
356:
346:
309:
306:
291:
249:
245:stigmasterol
237:progesterone
226:
221:multivitamin
199:
190:
177:copy editing
175:may require
174:
149:
133:
132:
113:Headquarters
87:Merged with
1351:Parke-Davis
1034:Trevena Inc
902:Mentholatum
710:AbbVie Inc.
296:AB to form
233:cholic acid
1453:Categories
1411:ViroPharma
1311:Massengill
1039:Ultragenyx
770:Bioverativ
624:2020-11-18
580:2020-05-07
338:References
259:prednisone
219:Unicap, a
185:editing it
117:Portage MI
1361:Qualitest
1231:CancerVax
1014:Sheffield
1004:RespireRx
999:Regeneron
850:Intercept
830:Genentech
820:Eli Lilly
805:CytoSport
795:Ceragenix
554:March 30,
294:Pharmacia
229:cortisone
193:July 2023
140:, by Dr.
99:Successor
89:Pharmacia
1241:CoTherix
1236:Cephalon
1119:Covidien
1109:Allergan
1099:Alkermes
1019:Spectrum
887:McKesson
780:Biovista
760:BioCryst
548:Barron's
522:cite web
440:cite web
414:21779154
386:Steroids
365:cite web
326:See also
283:Lincocin
252:Schering
241:Rhizopus
91:to form
41:Industry
1396:Trubion
1246:Covance
1226:Bradley
1175:, 2013)
1173:Ireland
1169:Perrigo
1165:, 2013)
1163:Ireland
1155:, 2012)
1153:Ireland
1145:, 2014)
1143:Ireland
1135:, 2014)
1133:Ireland
1125:, 2007)
1123:Ireland
1115:, 2015)
1113:Ireland
1105:, 2011)
1103:Ireland
1095:, 2013)
1093:Ireland
1089:Actavis
1059:Viatris
957:Hospira
947:Ovation
942:Organon
937:NovaBay
922:Moderna
860:Ethicon
790:Century
775:Biovest
735:Alnylam
730:Alexion
720:Advaxis
698:Current
406:1481225
320:Viatris
287:Rogaine
275:Halcion
256:steroid
156:History
107:Viatris
74: (
66:Defunct
56: (
51:Founded
1494:Pfizer
1421:Zonite
1401:Upjohn
1336:Nuvelo
1331:Nereus
1326:Naurex
1251:Cubist
1221:Biolex
1206:Amylin
1073:Former
1054:Vertex
962:Searle
952:Pfizer
765:Biogen
755:Baxter
412:
404:
302:Pfizer
285:, and
279:Motrin
119:, U.S.
1416:Wyeth
1406:Verus
1386:Tanox
1366:Rib-X
1341:Ortho
1321:Mylan
1276:Genta
1211:ARIAD
1189:Other
1029:Titan
994:Quark
840:Ionis
810:CytRx
800:Combe
740:Amgen
725:Alcon
410:S2CID
312:Mylan
271:Xanax
1291:King
1286:ISTA
1266:Epix
1216:Barr
1196:Alza
556:2020
528:link
446:link
402:PMID
371:link
84:Fate
76:1995
69:1995
58:1886
54:1886
1391:TAP
1346:OSI
575:CNN
491:doi
394:doi
1455::
1296:KV
617:.
598:.
573:.
545:.
524:}}
520:{{
512:.
487:17
485:.
462:.
442:}}
438:{{
430:.
408:.
400:.
390:57
388:.
367:}}
363:{{
355:.
322:.
289:.
281:,
277:,
273:,
1171:(
1161:(
1151:(
1141:(
1131:(
1121:(
1111:(
1101:(
1091:(
683:e
676:t
669:v
627:.
602:.
583:.
558:.
530:)
499:)
497:.
493::
479:4
466:.
448:)
416:.
396::
373:)
206:)
200:(
195:)
191:(
187:.
181:.
78:)
60:)
23:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
