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574:, can help strengthen the muscles that control urination. Fluid management, which focuses on avoiding excessive caffeine and alcohol intake, is advised to reduce the rate at which the bladder fills and minimize irritation to the bladder. Weight management and maintaining a healthy diet contribute to overall bladder health, especially when weight loss is able to reduce abdominal compression of the bladder. Adopting these behavioral and lifestyle changes can often improve the condition and enhance the effectiveness of other treatment approaches.
497:
specific to overactive bladder. General questionnaires include: American
Urological Association Symptom Index (AUASI), Urogenital Distress Inventory (UDI), Incontinence Impact Questionnaire (IIQ), and Bristol Female Lower Urinary Tract Symptoms (BFLUTS). Overactive bladder questionnaires include: Overactive Bladder Questionnaire (OAB-q), Urgency Questionnaire (UQ), Primary OAB Symptom Questionnaire (POSQ), and the International Consultation on Incontinence Questionnaire (ICIQ).
112:
36:
516:(blood in the urine) which are typically absent in OAB. Bladder cancer usually includes hematuria and can include pain, both not associated with OAB, and the common symptoms of OAB (urgency, frequency, and nocturia) may be absent. BPH frequently includes symptoms at the time of voiding as well as sometimes including pain or hematuria, and all of these are not usually present in OAB.
950:. Botulinum Toxin A injections into the bladder wall can suppress involuntary bladder contractions by blocking nerve signals and may be effective for up to 9 months. The growing knowledge of pathophysiology of overactive bladder fueled a huge amount of basic and clinical research in this field of pharmacotherapy.
528:
There is some controversy about the classification and diagnosis of OAB. Some sources classify overactive bladder into two different variants: "wet" (i.e., an urgent need to urinate with involuntary leakage) or "dry" (i.e., an urgent need to urinate but no involuntary leakage). Wet variants are more
409:
is considered abnormal if the person urinates more than eight times in a day. This frequency is usually monitored by having the person keep a voiding diary where they record urination episodes. The number of episodes varies depending on sleep, fluid intake, medications, and up to seven is considered
1013:
is increasing. However, a recent
Finnish population-based survey suggested that the number of people affected had been largely overestimated due to methodological shortcomings regarding age distribution and low participation (in earlier reports). It is suspected, then, that OAB affects approximately
637:
Patients taking oxybutynin and other anticholinergic drugs experience a 70% reduction of incontinence episode frequency, on average. Approximately 1 in 4 patients experience complete dryness while taking oxybutynin. Therefore, medication management alone is sufficient for a substantial minority, but
428:
It is important that the clinician and the person with overactive bladder both reach a consensus on the term, 'urgency.' Some common phrases used to describe OAB include, 'When I've got to go, I've got to go,' or 'When I have to go, I have to rush, because I think I will wet myself.' Hence the term,
416:
is a symptom where the person complains of interrupted sleep because of an urge to void and, like the urinary frequency component, is affected by similar lifestyle and medical factors. Individual waking events are not considered abnormal, one study in
Finland established two or more voids per night
304:
Overactive bladder affects approximately 11% of the population and more than 40% of people with overactive bladder have incontinence. Conversely, about 40% to 70% of urinary incontinence is due to overactive bladder. Overactive bladder is not life-threatening, but most people with the condition have
496:
Psychometrically robust self-completion questionnaires are generally recognized as a valid way of measuring a person's signs and symptoms, but there does not exist a single ideal questionnaire. These surveys can be divided into two groups: general surveys of lower urinary tract symptoms and surveys
988:
Because overactive bladder is most commonly associated with aging, the majority of patients experience symptoms (with or without incontinence) for the rest of their lives. A minority of age-related OAB cases may be cured or indefinitely suppressed by medications and behavioral modification. If the
577:
Most patients are not able to eliminate incontinence and other symptoms of OAB with lifestyle and behavioral modifications alone. However, numerous studies have demonstrated that these therapies are effective in improving quality of life, and some data shows that they increase the likelihood that
420:
Urge incontinence is a form of urinary incontinence characterized by the involuntary loss of urine occurring for no apparent reason while feeling urinary urgency as discussed above. Like frequency, the person can track incontinence in a diary to assist with diagnosis and management of symptoms.
383:
Overactive bladder is estimated to occur in 7–27% of men and 9–43% of women. It becomes more common with age. Some studies suggest that the condition is more common in women, especially when associated with loss of bladder control. Economic costs of overactive bladder were estimated in the United
367:
type, are only recommended if other measures are not effective. They are no more effective than behavioral methods; however, they are associated with side effects, particularly in older people. Some non-invasive electrical stimulation methods appear effective while they are in use. Injections of
544:
The usual first suggested treatment for a person with overactive bladder is a combination of lifestyle changes, exercises to strengthen the person's pelvic floor, and manage how much the person drinks and when during the day ("fluid management"). Patients who continue to experience incontinence
402:
is considered the hallmark symptom of OAB, but there are no clear criteria for what constitutes urgency and studies often use other criteria. Urgency is currently defined by the
International Continence Society (ICS), as of 2002, as "Sudden, compelling desire to pass urine that is difficult to
1017:
The
American Urological Association reports studies showing rates as low as 7% to as high as 27% in men and rates as low as 9% to 43% in women. Urge incontinence was reported as higher in women. Older people are more likely to be affected, and the number of symptoms increases with age.
569:
Behavioral and lifestyle changes are commonly recommended as the first-line option for treating overactive bladder. These include bladder training, which involves scheduled voiding (urination) and gradually increasing the time between bathroom visits. Pelvic floor exercises, known as
1920:
Shumaker SA, Wyman JF, Uebersax JS, McClish D, Fantl JA (October 1994). "Health-related quality of life measures for women with urinary incontinence: the
Incontinence Impact Questionnaire and the Urogenital Distress Inventory. Continence Program in Women (CPW) Research Group".
301:) may occur with this condition. This condition is also sometimes characterized by a sudden and involuntary contraction of the bladder muscles, in response to excitement or anticipation. This in turn leads to a frequent and urgent need to urinate.
324:
may worsen the symptoms. People often have the symptoms for a long time before seeking treatment and the condition is sometimes identified by caregivers. Diagnosis is based on a person's signs and symptoms and requires other problems such as
1191:
Gormley EA, Lightner DJ, Burgio KL, Chai TC, Clemens JQ, Culkin DJ, Das AK, Foster HE, Scarpero HM, Tessier CD, Vasavada SP (December 2012). "Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline".
2651:
Scarneciu, Ioan; Lupu, Sorin; Bratu, Ovidiu
Gabriel; Teodorescu, Andreea; Maxim, Laurian Stefan; Brinza, Adrian; Laculiceanu, Alexandru Georgian; Rotaru, Ruxandra Maria; Lupu, Aura-Mihaela; Scarneciu, Camelia Cornelia (2021-10-14).
980:, which is part of the small intestine. This procedure is rarely performed, and is only done for patients who have proven resistant to all other forms of treatment. This procedure can greatly enlarge urine volume in the bladder.
445:. It is also possible that the increased contractile nature originates from within the urothelium and lamina propria, and abnormal contractions in this tissue could stimulate dysfunction in the detrusor or whole bladder.
1282:
Hargreaves, Emma; Baker, Katherine; Barry, Gill; Harding, Christopher; Zhang, Yingying; Kandala, Ngianga-Bakwin; Zhang, Xiaowen; Kernohan, Ashleigh; Clarkson, Carl E (2022-09-23). Cochrane
Incontinence Group (ed.).
3483:
3468:
3449:
403:
defer." The previous definition was "Strong desire to void accompanied by fear of leakage or pain." The definition does not address the immediacy of the urge to void and has been criticized as subjective.
1647:
Tikkinen KA, Johnson TM, Tammela TL, Sintonen H, Haukka J, Huhtala H, Auvinen A (March 2010). "Nocturia frequency, bother, and quality of life: how often is too often? A population-based study in
Finland".
529:
common than dry variants. The distinction is not absolute; one study suggested that many classified as "dry" were actually "wet" and that people with no history of any leakage may have had other syndromes.
2768:
Milsom I, Abrams P, Cardozo L, Roberts RG, Thüroff J, Wein AJ (June 2001). "How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study".
1829:
457:
is in place, the catheter may be blocked by blood, thick sediment, or a kink in the catheter or drainage tubing. Sometimes spasms are caused by the catheter irritating the bladder,
1009:
had OAB. The number of people affected with OAB increases with age, thus it is expected that OAB will become more common in the future as the average age of people living in the
2046:
965:
If non-invasive and pharmacological approaches are not helpful, some people may be eligible for a surgical procedure to treat overactive bladder. Surgical options may include
3213:
2712:
Stewart WF, Van Rooyen JB, Cundiff GW, Abrams P, Herzog AR, Corey R, Hunt TL, Wein AJ (May 2003). "Prevalence and burden of overactive bladder in the United States".
1141:
Gormley EA, Lightner DJ, Faraday M, Vasavada SP (May 2015). "Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline amendment".
821:
10% of
Caucasians and 19% of black people have a genetic difference which causes them to lack a certain enzyme. Lack of this enzyme makes the drug less effective.
796:
10% of Caucasians and 19% of black people have a genetic difference which causes them to lack a certain enzyme. Lack of this enzyme makes the drug less effective.
1102:
2435:
493:. If there is an underlying metabolic or pathologic condition that explains the symptoms, the symptoms may be considered part of that disease and not OAB.
485:, and ultrasound are generally not needed. Additionally, urine culture may be done to rule out infection. The frequency/volume chart may be maintained and
340:
The amount of urine passed during each urination is relatively small. Pain while urinating suggests that there is a problem other than overactive bladder.
1847:
421:
Urge incontinence can also be measured with pad tests, and these are often used for research purposes. Some people with urge incontinence also have
1406:"Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: A systematic review and meta-analysis"
56:
Several sections with inaccurate or outdated information; lack of compliance with Manual of Style; excessive inline citations; copyediting issues.
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Sacco E, et al. (2009). "Investigational drug therapies for overactive bladder syndrome: the potential alternatives to anticholinergics".
2540:
Sacco E, Pinto F, Bassi P (April 2008). "Emerging pharmacological targets in overactive bladder therapy: experimental and clinical evidences".
957:
and causes urine to pass out of it. Both invasive and non-invasive electrical stimulation procedures may be used to treat overactive bladder.
1767:"Urothelial/lamina propria spontaneous activity and the role of M3 muscarinic receptors in mediating rate responses to stretch and carbachol"
2076:
Anger JT, Le TX, Nissim HA, Rogo-Gupta L, Rashid R, Behniwal A, Smith AL, Litwin MS, Rodriguez LV, Wein AJ, Maliski SL (November 2012).
1808:
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Sacco E, Paolillo M, Totaro A, Pinto F, Volpe A, Gardi M, Bassi PF (2008). "Botulinum toxin in the treatment of overactive bladder".
477:
Diagnosis of OAB is made primarily on the person's signs and symptoms and by ruling out other possible causes such as an infection.
3397:
976:
One surgical intervention, called a cystoplasty, involves the enlargement of the bladder using tissue taken from the patient's
437:
The cause of OAB is usually unclear, and indeed there may be multiple causes. It is often associated with overactivity of the
3116:
2462:
2521:
Sacco E, Bientinesi R (2012). "Future perspectives in pharmacological treatments options for overactive bladder syndrome".
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episodes, or who express a desire for medication along with therapy, may be treated with several classes of drugs, notably
2947:
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60:
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Araklitis G, Cardozo L (November 2017). "Safety issues associated with using medication to treat overactive bladder".
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to a degree that it negatively affects a person's life. The frequent need to urinate may occur during the day,
220:
1366:"Use of free uroflowmetry vs pressure-flow studies in the diagnosis of overactive bladder syndrome in females"
3045:
1546:"Diagnosis and Treatment of Overactive Bladder (Non-Neurogenic) in Adults: AUA/SUFU Guideline Amendment 2019"
2884:
Sacco E, Bientinesi R, Marangi F, D'Addessi A, Racioppi M, Gulino G, Pinto F, Totaro A, Bassi P (2011). "".
2814:
Tikkinen KA, Tammela TL, Rissanen AM, Valpas A, Huhtala H, Auvinen A (February 2007). Madersbacher S (ed.).
953:
Overactive bladder may be treated with electrical stimulation, which aims to reduce the contractions of the
380:
are generally not recommended. A diary to track problems can help determine whether treatments are working.
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561:. As a last resort if all other treatment options fail, invasive surgical procedures may be performed.
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Hutchinson, Alexander; Nesbitt, Alexander; Joshi, Andre; Clubb, Adrian; Perera, Marlon (Sep 2020).
586:
Medications are a common treatment option for people with overactive bladder syndrome. A number of
2627:"Overview | Urinary incontinence and pelvic organ prolapse in women: management | Guidance | NICE"
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Lightner, Deborah J.; Gomelsky, Alexander; Souter, Lesley; Vasavada, Sandip P. (September 2019).
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consumption, and drinking moderate fluids, can also have benefits. Medications, typically of the
326:
148:
3382:
2339:"Mirabegron: a review of recent data and its prospects in the management of overactive bladder"
1738:
Sussman DO (September 2007). "Overactive bladder: treatment options in primary care medicine".
970:
954:
558:
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214:
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1103:"Diagnosis and Treatment of Overactive Bladder (Non-Neurogenic) in Adults: AUA/SUFU Guideline"
618:) are frequently used to treat overactive bladder. Long term use, however, has been linked to
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1514:
392:
Overactive bladder is characterized by a group of four symptoms: urgency, urinary frequency,
344:
230:
2816:"Is the prevalence of overactive bladder overestimated? A population-based study in Finland"
2269:
Ouslander, Joseph; Reyes, Bernardo (2022). "Chapter 477: Caring for the Geriatric Patient".
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396:, and urge incontinence. Urge incontinence is not present in the "dry" classification.
308:
The cause of overactive bladder is unknown. Risk factors include obesity, caffeine, and
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1458:"Electrical stimulation with non-implanted electrodes for overactive bladder in adults"
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1982:
1965:
536:, but when they occur together, the condition is usually known as mixed incontinence.
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Nowakowski Ł, Futyma K, Ziętek A, Bogusiewicz M, Gałczyński K, Rechberger T (2016).
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549:. Patients who prove resistant to medications and therapy may then be treated with
469:, although most people eventually adjust to the irritation and the spasms go away.
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1257:(10 ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 890–891.
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Stewart F, Gameiro LF, El Dib R, Gameiro MO, Kapoor A, Amaro JL (December 2016).
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993:, then symptoms should resolve after the underlying problem has been treated.
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1964:
Coyne K, Schmier J, Hunt T, Corey R, Liberman J, Revicki D (March 2000).
1870:"Objective Evaluation of Overactive Bladder: Which Surveys Should I Use?"
1807:. MedlinePlus, the National Institutes of Health's Web site. 2010-03-09.
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2078:"How dry is "OAB-dry"? Perspectives from patients and physician experts"
453:
If bladder spasms occur or there is no urine in the drainage bag when a
285:) is a common condition where there is a frequent feeling of needing to
3073:
3028:
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2980:
1934:
1615:
901:
less researched for safety and efficacy than Tolterodine and Oxybutynin
862:
less researched for safety and efficacy than Tolterodine and Oxybutynin
844:
less researched for safety and efficacy than Tolterodine and Oxybutynin
751:
723:
701:
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2170:. Medical and Advanced Surgical Management of Pelvic Floor Disorders.
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259:
1966:"PRN6: developing a specific HRQL instrument for overactive bladder"
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Weill Cornell Medical College Department of Urology. Archived from
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458:
454:
413:
393:
360:
343:
Specific treatment is not always required. If treatment is desired
290:
3529:
1999:"Lower urinary tract symptomatology: Its definition and confusion"
557:(Botox) and other minimally-invasive surgical procedures, such as
520:
causes high frequency and volume, though not necessarily urgency.
189:
injury; over-consumption of water and caffeine; UTI; pelvic injury
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137:
124:
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International Urogynecology Journal and Pelvic Floor Dysfunction
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2211:"Overactive bladder syndrome: Management and treatment options"
1828:
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111:
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Earlier reports estimated that about one in six adults in the
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OAB causes similar symptoms to some other conditions such as
462:
2650:
1919:
1682:
Campbell-Walsh Urology, Tenth Edition, Chapter 66, Page 1948
1600:"Symptom-based diagnosis of overactive bladder: an overview"
1338:. Rochester, MN: Mayo Clinic Scientific Press. p. 339.
2448:
2208:
1455:
1281:
841:
higher rates of constipation and dry mouth than tolterodine
2767:
1764:
678:
available as generic in places including the United States
441:, a pattern of bladder muscle contraction observed during
351:, and other behavioral methods are initially recommended.
1190:
744:
patch commonly causes skin irritation which can be severe
384:
States at US$ 12.6 billion and 4.2 billion Euro in 2000.
2477:
2449:
Chancellor, Michael B; Christopher Smith (August 2011).
512:(BPH). Urinary tract infections often involve pain and
465:. Such spasms can be controlled with medication such as
209:
Based on symptoms after ruling out other possible causes
2809:
2807:
2075:
1285:"Acupuncture for treating overactive bladder in adults"
27:
Condition where a person has a frequent need to urinate
1765:
Moro C, Uchiyama J, Chess-Williams R (December 2011).
429:'fear of leakage,' is an important concept to people.
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1963:
1834:"Five Things Physicians and Patients Should Question"
3431:
2804:
1516:
Overactive bladder syndrome and urinary incontinence
1403:
1014:
half the number of individuals as earlier reported.
1740:
The Journal of the American Osteopathic Association
672:
available in market longer than other drugs for OAB
642:the majority, of patients with overactive bladder.
564:
2758:
2168:Obstetrics and Gynecology Clinics of North America
1364:
942:in adults with neurological conditions, including
2962:
1519:. Oxford: Oxford University Press. pp. 7–8.
859:severe dry mouth less common than with oxybutynin
838:More effective for some symptoms than Tolterodine
3578:
2426:"FDA approves Botox for loss of bladder control"
2293:
2162:White, Nicola; Iglesia, Cheryl B. (2016-03-01).
1758:
1593:
1591:
1589:
1404:Ruxton K, Woodman RJ, Mangoni AA (August 2015).
1356:
741:lower rate of dry mouth as compared to pill form
2707:
2705:
2539:
2520:
2336:
2133:, Treasure Island (FL): StatPearls Publishing,
989:OAB is due to a different condition, such as a
919:, but does not require that enzyme to be active
815:fewer side effects than short-acting Oxybutynin
790:fewer side effects than short-acting Oxybutynin
763:fewer side effects than short-acting Oxybutynin
713:fewer side effects than short-acting Oxybutynin
681:more side effects than alternatives, including
2268:
1915:
1913:
1335:Mayo Clinic internal medicine concise textbook
448:
3207:
2948:
2386:Diokno, Ananias; Ingber, Michael (Nov 2006).
1586:
938:Botulinum toxin A (Botox) is approved by the
922:it may avoid drug interactions of Tolterodine
675:many studies provide support of effectiveness
410:normal if consistent with the other factors.
2702:
2385:
2161:
1733:
1731:
1537:
648:Comparison of overactive bladder medication
578:medications can keep the OAB under control.
2124:
1910:
1867:
1462:The Cochrane Database of Systematic Reviews
272:~40% of elderly adults, increasing with age
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2271:Harrison's Principles of Internal Medicine
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425:and this can complicate clinical studies.
177:Age-related, or Secondary to other illness
110:
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2654:"Overactive bladder: A review and update"
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2014:
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769:applied to abdomen, arms, or thighs daily
79:Learn how and when to remove this message
2273:(21st ed.). New York: McGraw Hill.
1410:British Journal of Clinical Pharmacology
1101:American Urological Association (2014).
199:Old age, obesity, caffeine, constipation
2438:from the original on 24 September 2015.
2337:Sacco E, Bientinesi R (December 2012).
1822:
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1604:Canadian Urological Association Journal
1289:Cochrane Database of Systematic Reviews
14:
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2215:Australian Journal of General Practice
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1045:
553:interventions, such as treatment with
3195:
3117:Urologic chronic pelvic pain syndrome
2936:
2658:Experimental and Therapeutic Medicine
2582:
2388:"Oxybutynin in Detrusor Overactivity"
2264:
2262:
2157:
2155:
2153:
1996:
1691:
1451:
1449:
1331:
1250:
960:
955:muscle that tenses around the bladder
925:little existing research on this drug
884:little existing research on this drug
775:little existing research on this drug
387:
2928:. U.S. National Library of Medicine.
2125:Harris, Shauna; Riggs, John (2024),
1597:
1254:Danforth's obstetrics and gynecology
691:severe dry mouth more often reported
372:into the bladder is another option.
29:
1874:Current Bladder Dysfunction Reports
1846:, American Urogynecologic Society,
1028:National Association For Continence
24:
2619:
2259:
2150:
1446:
25:
3598:
2877:
2392:Urologic Clinics of North America
1868:Shy M, Fletcher SG (March 2013).
1850:from the original on June 2, 2015
1275:
523:
489:may be done to exclude tumor and
2865:
2782:10.1046/j.1464-410x.2001.02228.x
2016:10.1111/j.1442-2042.2007.01907.x
2003:International Journal of Urology
1533:from the original on 2016-03-05.
1371:Eur J Obstet Gynecol Reprod Biol
1352:from the original on 2016-03-05.
1271:from the original on 2016-03-05.
565:Lifestyle and behavioral therapy
34:
3251:Costovertebral angle tenderness
2644:
2576:
2533:
2514:
2471:
2442:
2418:
2379:
2343:Therapeutic Advances in Urology
2330:
2287:
2202:
2118:
2069:
2039:
1990:
1957:
1861:
1830:American Urogynecologic Society
1811:from the original on 2010-12-04
1797:
1685:
1676:
1640:
1506:
996:
973:, or augmentation cystoplasty.
337:is also a good diagnostic aid.
136:Frequent feeling of needing to
3041:Neurogenic bladder dysfunction
1474:10.1002/14651858.CD010098.pub4
1397:
1325:
1301:10.1002/14651858.CD013519.pub2
1220:
581:
417:as affecting quality of life.
264:Often but not always incurable
13:
1:
3046:Bladder sphincter dyssynergia
2308:10.1080/14740338.2017.1376646
2296:Expert Opinion on Drug Safety
1983:10.1016/s1098-3015(11)70554-x
1783:10.1016/j.urology.2011.08.039
1228:"Urinary Bladder, Overactive"
1038:
933:
539:
241:, medications, Botox, surgery
3361:Lower urinary tract symptoms
2841:10.1371/journal.pone.0000195
2127:"Mixed Urinary Incontinence"
1662:10.1016/j.eururo.2009.03.080
1383:10.1016/j.ejogrb.2016.10.054
983:
940:Food and Drug Administration
738:patch changed every 3–4 days
510:benign prostatic hyperplasia
472:
237:, drinking moderate fluids,
7:
1563:10.1097/JU.0000000000000309
1021:
534:stress urinary incontinence
449:Catheter-related irritation
105:Overactive bladder syndrome
54:. The specific problem is:
10:
3603:
2597:10.1177/039156030907600301
2492:10.1177/039156030807500102
2451:Botulinum Toxin in Urology
2094:10.1016/j.juro.2012.07.044
1206:10.1016/j.juro.2012.09.079
1155:10.1016/j.juro.2015.01.087
694:user takes 2-3 pills a day
3587:Urinary bladder disorders
3539:
3435:
3396:
3353:
3327:
3264:
3233:
3109:
3079:Non-gonococcal urethritis
3064:
3004:
2971:
2726:10.1007/s00345-002-0301-4
2554:10.1007/s00192-007-0529-z
2404:10.1016/j.ucl.2006.06.003
2180:10.1016/j.ogc.2015.10.002
1886:10.1007/s11884-012-0167-2
1251:Gibbs, Ronald S. (2008).
647:
432:
268:
258:
245:
226:
213:
203:
193:
181:
173:
165:
157:
147:
130:
118:
109:
101:
96:
3132:Retroperitoneal fibrosis
3051:Vesicointestinal fistula
2714:World Journal of Urology
2355:10.1177/1756287212457114
2227:10.31128/AJGP-11-19-5142
1997:Homma Y (January 2008).
1923:Quality of Life Research
669:well known by physicians
634:) may be used, as well.
327:urinary tract infections
3127:Urinary tract infection
1841:: an initiative of the
1598:Wein A (October 2011).
1332:Ghosh, Amit K. (2008).
991:urinary tract infection
502:urinary tract infection
331:neurological conditions
295:Loss of bladder control
221:neurological conditions
3383:Extravasation of urine
2670:10.3892/etm.2021.10879
2082:The Journal of Urology
1550:The Journal of Urology
1194:The Journal of Urology
1143:The Journal of Urology
971:sacral neuromodulation
624:β3 adrenergic receptor
559:sacral neuromodulation
439:detrusor urinae muscle
345:pelvic floor exercises
231:Pelvic floor exercises
215:Differential diagnosis
3056:Vesicoureteral reflux
3019:Interstitial cystitis
1513:Abrams, Paul (2011).
532:OAB is distinct from
3272:Urinary incontinence
3164:Urinary incontinence
3122:Obstructive uropathy
3034:Hemorrhagic cystitis
2922:"Overactive Bladder"
2898:10.5301/RU.2011.8886
2164:"Overactive Bladder"
2057:on 21 September 2013
2047:"Overactive Bladder"
1706:10.5301/RU.2012.8972
1692:Sacco E (2012). "".
1200:(6 Suppl): 2455–63.
312:. Poorly controlled
305:problems for years.
161:More common with age
61:improve this article
50:to meet Knowledge's
3297:Post-void dribbling
2832:2007PLoSO...2..195T
1805:"Urinary catheters"
1610:(Suppl 2): S135–6.
1033:Underactive bladder
915:same metabolite as
423:stress incontinence
322:chronic pelvic pain
318:functional mobility
254:drugs, β3 agonists
3540:External resources
3292:Nocturnal enuresis
3223:Signs and symptoms
3091:Urethral stricture
2996:Ureteric stricture
2434:. 24 August 2008.
2051:Cornell University
1935:10.1007/bf00451721
1616:10.5489/cuaj.11183
961:Invasive surgeries
948:spinal cord injury
944:multiple sclerosis
756:Topical medication
518:Diabetes insipidus
388:Signs and symptoms
279:Overactive bladder
97:Overactive bladder
3574:
3573:
3429:
3428:
3319:Urinary retention
3189:
3188:
3101:Urethral caruncle
3086:Urethral syndrome
2770:BJU International
2464:978-3-642-03579-1
2302:(11): 1273–1280.
1777:(6): 1442.e9–15.
1422:10.1111/bcp.12617
967:urinary diversion
931:
930:
728:transdermal patch
487:cystourethroscopy
407:Urinary frequency
374:Urinary catheters
355:in those who are
299:urge incontinence
276:
275:
205:Diagnostic method
91:Medical condition
89:
88:
81:
52:quality standards
43:This article may
18:Urge incontinence
16:(Redirected from
3594:
3433:
3432:
3282:Diurnal enuresis
3256:Vesical tenesmus
3225:relating to the
3216:
3209:
3202:
3193:
3192:
2963:Diseases of the
2957:
2950:
2943:
2934:
2933:
2929:
2917:
2871:
2870:
2869:
2863:
2853:
2843:
2811:
2802:
2801:
2765:
2756:
2755:
2737:
2709:
2700:
2699:
2689:
2648:
2642:
2641:
2639:
2638:
2623:
2617:
2616:
2580:
2574:
2573:
2537:
2531:
2530:
2518:
2512:
2511:
2475:
2469:
2468:
2446:
2440:
2439:
2422:
2416:
2415:
2383:
2377:
2376:
2366:
2334:
2328:
2327:
2291:
2285:
2284:
2266:
2257:
2256:
2238:
2206:
2200:
2199:
2159:
2148:
2147:
2146:
2145:
2122:
2116:
2115:
2105:
2073:
2067:
2066:
2064:
2062:
2043:
2037:
2036:
2018:
1994:
1988:
1987:
1985:
1961:
1955:
1954:
1917:
1908:
1907:
1897:
1865:
1859:
1858:
1857:
1855:
1826:
1820:
1819:
1817:
1816:
1801:
1795:
1794:
1762:
1756:
1755:
1735:
1726:
1725:
1689:
1683:
1680:
1674:
1673:
1650:European Urology
1644:
1638:
1637:
1627:
1595:
1584:
1583:
1565:
1541:
1535:
1534:
1510:
1504:
1503:
1493:
1453:
1444:
1443:
1433:
1401:
1395:
1394:
1368:
1360:
1354:
1353:
1329:
1323:
1322:
1312:
1279:
1273:
1272:
1248:
1239:
1238:
1236:
1234:
1224:
1218:
1217:
1188:
1167:
1166:
1138:
1125:
1124:
1122:
1120:
1115:on 26 April 2015
1114:
1108:. Archived from
1107:
1098:
874:extended release
808:extended release
706:extended release
645:
644:
626:agonists (e.g.,
547:anticholinergics
467:butylscopolamine
349:bladder training
333:to be excluded.
235:bladder training
114:
94:
93:
84:
77:
73:
70:
64:
38:
37:
30:
21:
3602:
3601:
3597:
3596:
3595:
3593:
3592:
3591:
3577:
3576:
3575:
3570:
3569:
3535:
3534:
3444:
3430:
3425:
3411:Brewer infarcts
3392:
3349:
3323:
3260:
3229:
3220:
3190:
3185:
3105:
3096:Meatal stenosis
3060:
3000:
2967:
2961:
2920:
2880:
2875:
2874:
2864:
2812:
2805:
2766:
2759:
2710:
2703:
2649:
2645:
2636:
2634:
2631:www.nice.org.uk
2625:
2624:
2620:
2581:
2577:
2538:
2534:
2523:Eur Urol Review
2519:
2515:
2476:
2472:
2465:
2447:
2443:
2424:
2423:
2419:
2384:
2380:
2335:
2331:
2292:
2288:
2281:
2267:
2260:
2207:
2203:
2160:
2151:
2143:
2141:
2123:
2119:
2074:
2070:
2060:
2058:
2045:
2044:
2040:
1995:
1991:
1970:Value in Health
1962:
1958:
1918:
1911:
1866:
1862:
1853:
1851:
1843:ABIM Foundation
1839:Choosing Wisely
1832:(May 5, 2015),
1827:
1823:
1814:
1812:
1803:
1802:
1798:
1763:
1759:
1736:
1729:
1690:
1686:
1681:
1677:
1645:
1641:
1596:
1587:
1542:
1538:
1527:
1511:
1507:
1468:(2): CD010098.
1454:
1447:
1402:
1398:
1361:
1357:
1346:
1330:
1326:
1295:(9): CD013519.
1280:
1276:
1265:
1249:
1242:
1232:
1230:
1226:
1225:
1221:
1189:
1170:
1139:
1128:
1118:
1116:
1112:
1105:
1099:
1046:
1041:
1024:
1011:developed world
999:
986:
963:
936:
854:(short acting)
793:2 pills per day
785:(short-acting)
664:(short-acting)
584:
572:Kegel exercises
567:
555:botulinum toxin
542:
526:
475:
451:
435:
390:
370:botulinum toxin
365:anti-muscarinic
252:Anticholinergic
187:detrusor muscle
92:
85:
74:
68:
65:
58:
39:
35:
28:
23:
22:
15:
12:
11:
5:
3600:
3590:
3589:
3572:
3571:
3568:
3567:
3565:article/459340
3556:
3544:
3543:
3541:
3537:
3536:
3533:
3532:
3521:
3510:
3499:
3480:
3465:
3445:
3440:
3439:
3437:
3436:Classification
3427:
3426:
3424:
3423:
3418:
3413:
3408:
3402:
3400:
3394:
3393:
3391:
3390:
3385:
3380:
3379:
3378:
3373:
3368:
3357:
3355:
3351:
3350:
3348:
3347:
3342:
3337:
3331:
3329:
3325:
3324:
3322:
3321:
3316:
3315:
3314:
3309:
3304:
3299:
3294:
3289:
3284:
3279:
3268:
3266:
3262:
3261:
3259:
3258:
3253:
3248:
3243:
3237:
3235:
3231:
3230:
3227:urinary system
3219:
3218:
3211:
3204:
3196:
3187:
3186:
3184:
3183:
3182:
3181:
3176:
3171:
3161:
3156:
3155:
3154:
3149:
3144:
3134:
3129:
3124:
3119:
3113:
3111:
3107:
3106:
3104:
3103:
3098:
3093:
3088:
3083:
3082:
3081:
3070:
3068:
3062:
3061:
3059:
3058:
3053:
3048:
3043:
3038:
3037:
3036:
3031:
3026:
3024:Hunner's ulcer
3021:
3010:
3008:
3002:
3001:
2999:
2998:
2993:
2988:
2983:
2977:
2975:
2969:
2968:
2960:
2959:
2952:
2945:
2937:
2931:
2930:
2918:
2888:(in Italian).
2879:
2878:External links
2876:
2873:
2872:
2803:
2757:
2701:
2643:
2633:. 2 April 2019
2618:
2591:(3): 161–177.
2575:
2532:
2513:
2470:
2463:
2441:
2417:
2398:(4): 439–445.
2378:
2329:
2286:
2280:978-1264268504
2279:
2258:
2221:(9): 593–598.
2201:
2149:
2117:
2068:
2038:
1989:
1956:
1929:(5): 291–306.
1909:
1860:
1821:
1796:
1757:
1727:
1684:
1675:
1639:
1585:
1556:(3): 558–563.
1536:
1525:
1505:
1445:
1396:
1355:
1344:
1324:
1274:
1263:
1240:
1219:
1168:
1149:(5): 1572–80.
1126:
1043:
1042:
1040:
1037:
1036:
1035:
1030:
1023:
1020:
998:
995:
985:
982:
962:
959:
935:
932:
929:
928:
927:
926:
923:
920:
911:
905:
904:
903:
902:
899:
898:1 pill per day
894:
888:
887:
886:
885:
882:
881:1 pill per day
877:
866:
865:
864:
863:
860:
855:
848:
847:
846:
845:
842:
839:
836:
835:1 pill per day
831:
825:
824:
823:
822:
819:
818:1 pill per day
816:
811:
800:
799:
798:
797:
794:
791:
786:
779:
778:
777:
776:
773:
770:
764:
759:
748:
747:
746:
745:
742:
739:
736:
731:
720:
719:
718:
717:
716:1 pill per day
714:
709:
698:
697:
696:
695:
692:
689:
679:
676:
673:
670:
665:
658:
657:
654:
650:
649:
588:antimuscarinic
583:
580:
566:
563:
541:
538:
525:
524:Classification
522:
506:bladder cancer
474:
471:
450:
447:
434:
431:
389:
386:
274:
273:
270:
266:
265:
262:
256:
255:
249:
243:
242:
228:
224:
223:
217:
211:
210:
207:
201:
200:
197:
191:
190:
183:
179:
178:
175:
171:
170:
167:
163:
162:
159:
155:
154:
151:
145:
144:
134:
128:
127:
122:
116:
115:
107:
106:
103:
99:
98:
90:
87:
86:
42:
40:
33:
26:
9:
6:
4:
3:
2:
3599:
3588:
3585:
3584:
3582:
3566:
3562:
3561:
3557:
3555:
3551:
3550:
3546:
3545:
3542:
3538:
3531:
3527:
3526:
3522:
3520:
3516:
3515:
3511:
3509:
3505:
3504:
3500:
3498:
3494:
3490:
3489:
3485:
3481:
3479:
3475:
3474:
3470:
3466:
3464:
3460:
3456:
3455:
3451:
3447:
3446:
3443:
3438:
3434:
3422:
3419:
3417:
3414:
3412:
3409:
3407:
3404:
3403:
3401:
3399:
3395:
3389:
3386:
3384:
3381:
3377:
3374:
3372:
3369:
3367:
3364:
3363:
3362:
3359:
3358:
3356:
3352:
3346:
3343:
3341:
3338:
3336:
3333:
3332:
3330:
3326:
3320:
3317:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3274:
3273:
3270:
3269:
3267:
3263:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3238:
3236:
3232:
3228:
3224:
3217:
3212:
3210:
3205:
3203:
3198:
3197:
3194:
3180:
3177:
3175:
3172:
3170:
3167:
3166:
3165:
3162:
3160:
3157:
3153:
3150:
3148:
3145:
3143:
3142:Bladder stone
3140:
3139:
3138:
3135:
3133:
3130:
3128:
3125:
3123:
3120:
3118:
3115:
3114:
3112:
3108:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3080:
3077:
3076:
3075:
3072:
3071:
3069:
3067:
3063:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3016:
3015:
3012:
3011:
3009:
3007:
3003:
2997:
2994:
2992:
2989:
2987:
2984:
2982:
2979:
2978:
2976:
2974:
2970:
2966:
2965:urinary tract
2958:
2953:
2951:
2946:
2944:
2939:
2938:
2935:
2927:
2923:
2919:
2915:
2911:
2907:
2903:
2899:
2895:
2892:(4): 241–56.
2891:
2887:
2882:
2881:
2868:
2861:
2857:
2852:
2847:
2842:
2837:
2833:
2829:
2825:
2821:
2817:
2810:
2808:
2799:
2795:
2791:
2787:
2783:
2779:
2775:
2771:
2764:
2762:
2753:
2749:
2745:
2741:
2736:
2735:2027.42/42170
2731:
2727:
2723:
2720:(6): 327–36.
2719:
2715:
2708:
2706:
2697:
2693:
2688:
2683:
2679:
2675:
2671:
2667:
2663:
2659:
2655:
2647:
2632:
2628:
2622:
2614:
2610:
2606:
2602:
2598:
2594:
2590:
2586:
2579:
2571:
2567:
2563:
2559:
2555:
2551:
2548:(4): 583–98.
2547:
2543:
2536:
2529:(2): 120–126.
2528:
2524:
2517:
2509:
2505:
2501:
2497:
2493:
2489:
2485:
2481:
2474:
2466:
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2389:
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2374:
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2352:
2349:(6): 315–24.
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2250:
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2140:
2136:
2132:
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2121:
2113:
2109:
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2099:
2095:
2091:
2088:(5): 1811–5.
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2083:
2079:
2072:
2056:
2052:
2048:
2042:
2034:
2030:
2026:
2022:
2017:
2012:
2008:
2004:
2000:
1993:
1984:
1979:
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1971:
1967:
1960:
1952:
1948:
1944:
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1936:
1932:
1928:
1924:
1916:
1914:
1905:
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1896:
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1879:
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1806:
1800:
1792:
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1784:
1780:
1776:
1772:
1768:
1761:
1753:
1749:
1746:(9): 379–85.
1745:
1741:
1734:
1732:
1723:
1719:
1715:
1711:
1707:
1703:
1699:
1695:
1688:
1679:
1671:
1667:
1663:
1659:
1656:(3): 488–96.
1655:
1651:
1643:
1635:
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1626:
1621:
1617:
1613:
1609:
1605:
1601:
1594:
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1526:9780199599394
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1518:
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1483:
1479:
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1471:
1467:
1463:
1459:
1452:
1450:
1441:
1437:
1432:
1427:
1423:
1419:
1416:(2): 209–20.
1415:
1411:
1407:
1400:
1392:
1388:
1384:
1380:
1376:
1372:
1367:
1359:
1351:
1347:
1345:9781420067514
1341:
1337:
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1320:
1316:
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1264:9780781769372
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1256:
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1215:
1211:
1207:
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1199:
1195:
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1181:
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1175:
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1152:
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994:
992:
981:
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867:
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853:
850:
849:
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837:
834:
833:
832:
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827:
826:
820:
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814:
813:
812:
809:
805:
802:
801:
795:
792:
789:
788:
787:
784:
781:
780:
774:
772:new on market
771:
768:
765:
762:
761:
760:
757:
753:
750:
749:
743:
740:
737:
734:
733:
732:
729:
725:
722:
721:
715:
712:
711:
710:
707:
703:
700:
699:
693:
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688:
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680:
677:
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671:
668:
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663:
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651:
646:
643:
641:
635:
633:
629:
625:
621:
617:
613:
609:
605:
601:
597:
593:
590:drugs (e.g.,
589:
579:
575:
573:
562:
560:
556:
552:
548:
537:
535:
530:
521:
519:
515:
511:
507:
503:
498:
494:
492:
491:kidney stones
488:
484:
483:bladder scope
480:
470:
468:
464:
460:
456:
446:
444:
440:
430:
426:
424:
418:
415:
411:
408:
404:
401:
397:
395:
385:
381:
379:
375:
371:
366:
362:
359:, decreasing
358:
354:
350:
346:
341:
338:
336:
332:
328:
323:
319:
315:
311:
306:
302:
300:
296:
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284:
280:
271:
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257:
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244:
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229:
225:
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198:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
153:UTIs, anxiety
152:
150:
149:Complications
146:
143:
139:
135:
133:
129:
126:
123:
121:
117:
113:
108:
104:
100:
95:
83:
80:
72:
62:
57:
53:
49:
48:
41:
32:
31:
19:
3558:
3547:
3523:
3512:
3501:
3482:
3467:
3448:
3421:Mathe's sign
3416:Lloyd's sign
3306:
3173:
3159:Malakoplakia
3147:Kidney stone
3137:Urolithiasis
2925:
2889:
2885:
2823:
2819:
2776:(9): 760–6.
2773:
2769:
2717:
2713:
2661:
2657:
2646:
2635:. Retrieved
2630:
2621:
2588:
2584:
2578:
2545:
2541:
2535:
2526:
2522:
2516:
2483:
2479:
2473:
2450:
2444:
2429:
2420:
2395:
2391:
2381:
2346:
2342:
2332:
2299:
2295:
2289:
2270:
2236:10072/400893
2218:
2214:
2204:
2174:(1): 59–68.
2171:
2167:
2142:, retrieved
2130:
2120:
2085:
2081:
2071:
2059:. Retrieved
2055:the original
2041:
2009:(1): 35–43.
2006:
2002:
1992:
1973:
1969:
1959:
1926:
1922:
1880:(1): 45–50.
1877:
1873:
1863:
1852:, retrieved
1837:
1824:
1813:. Retrieved
1799:
1774:
1770:
1760:
1743:
1739:
1700:(1): 24–35.
1697:
1693:
1687:
1678:
1653:
1649:
1642:
1607:
1603:
1553:
1549:
1539:
1515:
1508:
1465:
1461:
1413:
1409:
1399:
1374:
1370:
1358:
1334:
1327:
1292:
1288:
1277:
1253:
1231:. Retrieved
1222:
1197:
1193:
1146:
1142:
1117:. Retrieved
1110:the original
1016:
1000:
997:Epidemiology
987:
975:
964:
952:
937:
909:Fesoterodine
687:constipation
639:
636:
616:fesoterodine
585:
576:
568:
551:neurological
543:
531:
527:
499:
495:
476:
452:
436:
427:
419:
412:
405:
398:
391:
382:
342:
339:
335:Uroflowmetry
310:constipation
307:
303:
298:
282:
278:
277:
195:Risk factors
142:incontinence
75:
66:
59:Please help
55:
44:
3549:MedlinePlus
3406:Addis count
3246:Renal colic
3152:Renal colic
2986:Ureterocele
2926:MedlinePlus
2826:(2): e195.
2664:(6): 1444.
2486:(1): 4–13.
1377:: 137–140.
917:Tolterodine
892:Darifenacin
829:Solifenacin
804:Tolterodine
783:Tolterodine
767:topical gel
608:solifenacin
604:tolterodine
596:hyoscyamine
592:darifenacin
582:Medications
479:Urodynamics
443:urodynamics
353:Weight loss
293:, or both.
239:weight loss
158:Usual onset
102:Other names
63:if you can.
3514:DiseasesDB
3074:Urethritis
3029:Trigonitis
2991:Megaureter
2981:Ureteritis
2637:2023-04-24
2144:2024-03-07
2131:StatPearls
1976:(2): 141.
1815:2010-12-01
1039:References
934:Procedures
752:Oxybutynin
724:Oxybutynin
702:Oxybutynin
662:Oxybutynin
628:mirabegron
600:oxybutynin
540:Management
357:overweight
247:Medication
3560:eMedicine
3530:236633002
3525:SNOMED CT
3398:Eponymous
3376:frequency
2678:1792-1015
2613:208148685
2508:208149855
2245:2208-7958
2188:0889-8545
1572:1527-3792
1482:2164/8446
984:Prognosis
683:dry mouth
514:hematuria
473:Diagnosis
269:Frequency
260:Prognosis
227:Treatment
185:Old age;
120:Specialty
3581:Category
3366:Nocturia
3345:Polyuria
3335:Oliguria
3312:Overflow
3287:Giggling
3277:Enuresis
3179:Overflow
3014:Cystitis
2914:36693916
2906:22237808
2886:Urologia
2860:17332843
2820:PLOS ONE
2798:23650548
2790:11412210
2752:15994916
2744:12811491
2696:34721686
2605:21086288
2585:Urologia
2570:23846583
2562:18196198
2500:21086369
2480:Urologia
2455:Springer
2436:Archived
2412:17011379
2373:23205058
2324:10862256
2316:28889761
2253:32864677
2196:26880508
2139:30480967
2112:22999694
2033:35527427
2025:18184169
1951:22892631
1904:23439804
1848:archived
1809:Archived
1791:22001099
1752:17908830
1722:39170650
1714:22287269
1694:Urologia
1670:19361907
1634:21989525
1580:31039103
1531:Archived
1500:27935011
1440:25735839
1391:27852010
1350:Archived
1319:36148895
1269:Archived
1214:23098785
1163:25623739
1022:See also
870:Trospium
852:Trospium
632:vibegron
620:dementia
612:trospium
459:prostate
455:catheter
414:Nocturia
394:nocturia
361:caffeine
314:diabetes
291:at night
166:Duration
132:Symptoms
69:May 2024
45:require
3508:D053201
3371:urgency
3265:Control
3241:Dysuria
3110:Any/all
3066:Urethra
3006:Bladder
2851:1805814
2828:Bibcode
2687:8549091
2431:Reuters
2364:3491758
2103:3571660
1943:7841963
1895:3579666
1854:June 1,
1771:Urology
1625:3193392
1491:6463833
1431:4541969
1310:9502659
735:no pill
656:Traits
504:(UTI),
400:Urgency
378:surgery
316:, poor
287:urinate
169:Chronic
138:urinate
125:Urology
47:cleanup
3554:001270
3497:788.31
3493:596.51
3478:N32.81
3388:Uremia
3340:Anuria
3328:Volume
3302:Stress
3169:Stress
2973:Ureter
2912:
2904:
2858:
2848:
2796:
2788:
2750:
2742:
2694:
2684:
2676:
2611:
2603:
2568:
2560:
2506:
2498:
2461:
2410:
2371:
2361:
2322:
2314:
2277:
2251:
2243:
2194:
2186:
2137:
2110:
2100:
2061:25 Aug
2031:
2023:
1949:
1941:
1902:
1892:
1789:
1750:
1720:
1712:
1668:
1632:
1622:
1578:
1570:
1523:
1498:
1488:
1438:
1428:
1389:
1342:
1317:
1307:
1261:
1233:1 June
1212:
1161:
1119:1 June
1007:Europe
653:Agent
508:, and
433:Causes
320:, and
219:Other
182:Causes
3473:10-CM
3463:N39.4
3459:N32.8
3354:Other
2910:S2CID
2794:S2CID
2748:S2CID
2609:S2CID
2566:S2CID
2504:S2CID
2320:S2CID
2029:S2CID
1947:S2CID
1718:S2CID
1113:(PDF)
1106:(PDF)
978:ileum
463:penis
174:Types
3519:3612
3503:MeSH
3488:9-CM
3307:Urge
3234:Pain
3174:Urge
2902:PMID
2856:PMID
2786:PMID
2740:PMID
2692:PMID
2674:ISSN
2601:PMID
2558:PMID
2496:PMID
2459:ISBN
2408:PMID
2369:PMID
2312:PMID
2275:ISBN
2249:PMID
2241:ISSN
2192:PMID
2184:ISSN
2135:PMID
2108:PMID
2063:2013
2021:PMID
1939:PMID
1900:PMID
1856:2015
1787:PMID
1748:PMID
1710:PMID
1666:PMID
1630:PMID
1576:PMID
1568:ISSN
1521:ISBN
1496:PMID
1436:PMID
1387:PMID
1340:ISBN
1315:PMID
1293:2022
1259:ISBN
1235:2015
1210:PMID
1159:PMID
1121:2015
1005:and
946:and
685:and
481:, a
3484:ICD
3469:ICD
3450:ICD
2894:doi
2846:PMC
2836:doi
2778:doi
2730:hdl
2722:doi
2682:PMC
2666:doi
2593:doi
2550:doi
2488:doi
2400:doi
2359:PMC
2351:doi
2304:doi
2231:hdl
2223:doi
2176:doi
2098:PMC
2090:doi
2086:188
2011:doi
1978:doi
1931:doi
1890:PMC
1882:doi
1779:doi
1744:107
1702:doi
1658:doi
1620:PMC
1612:doi
1558:doi
1554:202
1486:PMC
1478:hdl
1470:doi
1426:PMC
1418:doi
1379:doi
1375:207
1305:PMC
1297:doi
1202:doi
1198:188
1151:doi
1147:193
640:not
461:or
376:or
329:or
283:OAB
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.