Knowledge

Troponin

Source 📝

243:
the existence of several cardiac specific isoforms of TnT (cTnT) are described in the literature. No cardiac specific isoforms are known for human TnC. TnC in human cardiac muscle tissue is presented by an isoform typical for slow skeletal muscle. Another form of TnC, the fast skeletal TnC isoform, is more typical for fast skeletal muscles. cTnI is expressed only in myocardium. No examples of cTnI expression in healthy or injured skeletal muscle or in other tissue types are known. cTnT is probably less cardiac specific. The expression of cTnT in skeletal tissue of patients with chronic skeletal muscle injuries has been described.
37: 251:
plays an important positive role in improving the stability of cTnI molecule. cTnI, which is extremely unstable in its free form, demonstrates significantly better stability in complex with TnC or in ternary cTnI-cTnT-TnC complex. It has been demonstrated that stability of cTnI in native complex is significantly better than stability of the purified form of the protein or the stability of cTnI in artificial troponin complexes combined from purified proteins.
169:, but the specific versions of troponin differ between types of muscle. The main difference is that the TnC subunit of troponin in skeletal muscle has four calcium ion-binding sites, whereas in cardiac muscle there are only three. The actual amount of calcium that binds to troponin has not been definitively established. 250:
10 M). TnC, forming a complex with cTnI, changes the conformation of cTnI molecule and shields part of its surface. According to the latest data cTnI is released in the blood stream of the patient in the form of binary complex with TnC or ternary complex with cTnT and TnC. cTnI-TnC complex formation
598:
First cTnI and later cTnT were originally used as markers for cardiac cell death. Both proteins are now widely used to diagnose acute myocardial infarction (AMI), unstable angina, post-surgery myocardium trauma and some other related diseases with cardiac muscle injury. Both markers can be detected
314:
Cardiac troponins are a marker of all heart muscle damage, not just myocardial infarction, which is the most severe form of heart disorder. However, diagnostic criteria for raised troponin indicating myocardial infarction is currently set by the WHO at a threshold of 2 μg/L or higher. Critical
242:
TnT and TnI in cardiac muscle are presented by forms different from those in skeletal muscles. Two isoforms of TnI and two isoforms of TnT are expressed in human skeletal muscle tissue (skTnI and skTnT). Only one tissue-specific isoform of TnI is described for cardiac muscle tissue (cTnI), whereas
589:
In a community-based cohort study indicating the importance of silent cardiac damage, troponin I has been shown to predict mortality and first coronary heart disease event in men free from cardiovascular disease at baseline. In people with stroke, elevated blood troponin levels are not a useful
338:
placement can also cause immediate post-procedure elevated serum troponin levels. This can be problematic in a clinical setting as troponin values and guidance protocols become subject to more thoughtful interpretation. Essentially, making it difficult for a clinician to use troponin elevation
192:), and is the protein complex to which calcium binds to trigger the production of muscular force. Troponin has three subunits, TnC, TnI, and TnT, each playing a role in force regulation.. Under resting intracellular levels of calcium, tropomyosin covers the active actin sites to which 1318:
Amsterdam, E. A.; Wenger, N. K.; Brindis, R. G.; Casey, D. E.; Ganiats, T. G.; Holmes, D. R.; Jaffe, A. S.; Jneid, H.; Kelly, R. F.; Kontos, M. C.; Levine, G. N.; Liebson, P. R.; Mukherjee, D.; Peterson, E. D.; Sabatine, M. S.; Smalling, R. W.; Zieman, S. J. (23 September 2014).
599:
in patient's blood 3–6 hours after onset of the chest pain, reaching peak level within 16–30 hours. Elevated concentration of cTnI and cTnT in blood samples can be detected even 5–8 days after onset of the symptoms, making both proteins useful also for the late diagnosis of AMI.
238:
TnT is a tropomyosin-binding subunit which regulates the interaction of troponin complex with thin filaments; TnI inhibits ATP-ase activity of acto-myosin; TnC is a Ca-binding subunit, playing the main role in Ca dependent regulation of muscle contraction.
552:
can lead to increased troponin levels in up to one-third of subjects, but it is not linked to adverse health effects in these competitors. High troponin T levels have also been reported in patients with inflammatory muscle diseases such as
339:
diagnostically in this patient group. After stenting and related PCI procedures, troponin levels do return to standard levels once the stent has 'settled' and is no longer causing localized cardiac muscle inflammation.
1815:
Rifai N, Douglas PS, O'Toole M, Rimm E, Ginsburg GS (April 1999). "Cardiac troponin T and I, echocardiographic wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon".
506:
can also be accompanied by the release of troponins due to hypoxic cardiotoxic effects. Cardiac injury occurs in about one-third of severe CO poisoning cases, and troponin screening is appropriate in these patients.
196:(a molecular motor organized in muscle thick filaments) binds in order to generate force. When calcium becomes bound to specific sites in the N-domain of TnC, a series of protein structural changes occurs, such that 1321:"2014 AHA/ACC Guideline for the Management of Patients With Non-ST-Elevation Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines" 1559:
Hadziselimovic, Edina; Greve, Anders M.; Sajadieh, Ahmad; Olsen, Michael H.; Kesäniemi, Y. Antero; Nienaber, Christoph A.; Ray, Simon G.; Rossebø, Anne B.; Wachtell, Kristian; Nielsen, Olav W. (April 2023).
134:
open in the sarcoplasmic membrane and release calcium into the sarcoplasm. Some of this calcium attaches to troponin, which causes it to change shape, exposing binding sites for myosin (active sites) on the
1743:
Needham DM, Shufelt KA, Tomlinson G, Scholey JW, Newton GE (October 2004). "Troponin I and T levels in renal failure patients without acute coronary syndrome: a systematic review of the literature".
743: 452:
The distinction between cardiac and non-cardiac conditions is somewhat artificial; the conditions listed below are not primary heart diseases, but they exert indirect effects on the heart muscle.
157:
Troponin activation. Troponin C (red) binds Ca2+, which stabilizes the activated state, where troponin I (yellow) is no longer bound to actin. Troponin T (blue) anchors the complex on tropomyosin.
530:. Of course, patients with COPD exacerbations might also have concurrent myocardial infarction or pulmonary embolism, so care has to be taken to attribute increased troponin levels to COPD. 2308:
Katus HA, Remppis A, Looser S, Hallermeier K, Scheffold T, Kubler W (1989). "Enzyme linked immunoassay of cardiac troponin T for the detection of acute myocardial infarction in patients".
331:) in an individual with normal coronary arteries can also lead to increased troponins for example, it is presumed due to increased oxygen demand and inadequate supply to the heart muscle. 1964:
Erlacher P, Lercher A, Falkensammer J, et al. (April 2001). "Cardiac troponin and beta-type myosin heavy chain concentrations in patients with polymyositis or dermatomyositis".
154: 246:
Inside the cardiac troponin complex the strongest interaction between molecules has been demonstrated for cTnI – TnC binary complex especially in the presence of Ca ( KA = 1.5
1886:
Urhausen A, Scharhag J, Herrmann M, Kindermann W (September 2004). "Clinical significance of increased cardiac troponins T and I in participants of ultra-endurance events".
307:. A person who recently had a myocardial infarction has areas of damaged heart muscle and elevated cardiac troponin levels in the blood. This can also occur in people with 40:
Ribbon representation of the human cardiac troponin core complex (52 kDa core) in the calcium-saturated form. Blue = troponin C; green = troponin I; magenta = troponin T.
311:, a type of myocardial infarction involving severe constriction of the cardiac blood vessels. After a myocardial infarction troponins may remain high for up to 2 weeks. 2097:
Gaze DC, Collinson PO; Collinson, PO (December 2005). "Cardiac troponins as biomarkers of drug- and toxin-induced cardiac toxicity and cardioprotection".
1193:
Reiffert SU, Jaquet K, Heilmeyer LM Jr, Herberg FW (1998). "Stepwise subunit interaction changes by mono- and bisphosphorylation of cardiac troponin I".
1508:
Ferreira, Roberto Muniz; de Souza e Silva, Nelson Albuquerque; Salis, Lúcia Helena Alvares; Maia, Paula Dias; Horta, Lucas Felipe Bastos (2017-05-01).
1851:
Neumayr G, Gaenzer H, Pfister R, et al. (February 2001). "Plasma levels of cardiac troponin I after prolonged strenuous endurance exercise".
3265: 2475:"Comparison of Two Commercially Available Immunoassays for the Measurement of Bovine Cardiac Troponin I in Cattle with Induced Myocardial Injury" 1024: 870:
Thygesen, Kristian; Alpert, Joseph S.; Jaffe, Allan S.; Chaitman, Bernard R.; Bax, Jeroen J.; Morrow, David A.; White, Harvey D. (2018-10-30).
1562:"Association of high-sensitivity troponin T with outcomes in asymptomatic non-severe aortic stenosis: a post-hoc substudy of the SEAS trial" 537:
can have chronically elevated troponin T levels, which are linked to a poorer prognosis. Troponin I is less likely to be falsely elevated.
2273:
Cummins B, Auckland ML, Cummins P (1987). "Cardiac-specific troponin-I radioimmunoassay in the diagnosis of acute myocardial infarction".
5074: 687:
Takeda S, Yamashita A, Maeda K, Maeda Y (2003). "Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form".
83:. Measurements of cardiac-specific troponins I and T are extensively used as diagnostic and prognostic indicators in the management of 5094: 1921:
Kobayashi S, Tanaka M, Tamura N, Hashimoto H, Hirose S (September 1992). "Serum cardiac troponin T in polymyositis/dermatomyositis".
200:
is rolled away from myosin-binding sites on actin, allowing myosin to attach to the thin filament and produce force and shorten the
5026: 5011: 5006: 5001: 4996: 4986: 4907: 4616: 4596: 4566: 4561: 634:
Troponin elevation following cardiac cell necrosis starts within 2–3 hours, peaks in approx. 24 hours, and persists for 1–2 weeks.
5236: 5231: 5226: 5221: 4976: 4966: 4956: 4951: 4922: 4626: 4621: 3668: 3556: 3546: 3521: 3501: 3405: 3385: 2613: 319:. Other conditions that directly or indirectly lead to heart muscle damage and death can also increase troponin levels, such as 3628: 787:"Stable high-sensitivity cardiac troponin T levels and the association with frailty and prognosis in patients with chest pain" 2682: 1000: 578:
In 2020, it was found that patients with severe COVID-19 had higher troponin I levels compared to those with milder disease.
519: 1228:
Katrukha AG, Bereznikova AV, Esakova TV, Pettersson K, Lovgren T, Severina ME, Pulkki K, Vuopio-Pulkki LM, Gusev NB (1997).
3893: 2999: 748: 373:, where they also predict mortality and ventricular rhythm abnormalities. They can rise in inflammatory conditions such as 3258: 3030: 359: 2234:"Troponin I as a predictor of coronary heart disease and mortality in 70-year-old men: a community-based cohort study" 586:
Elevated troponin levels are prognostically important in many of the conditions in which they are used for diagnosis.
463:. There is an increased risk of mortality and length of stay in the intensive-care unit in these patients. In severe 1230:"Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex" 177:
In both cardiac and skeletal muscles, muscular force production is controlled primarily by changes in intracellular
381:
with heart muscle involvement (which is then termed myopericarditis). Troponins can also indicate several forms of
1473:
Tsai SH, Chu SJ, Hsu CW, Cheng SM, Yang SP (March 2008). "Use and interpretation of cardiac troponins in the ED".
4412: 1776:"Prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease: a meta-analysis" 181:
concentration. In general, when calcium rises, the muscles contract and, when calcium falls, the muscles relax.
4681: 4524: 3251: 1271:"Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes" 363: 5560: 5114: 2700: 328: 1320: 3821: 2606: 390: 273: 2142:"Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): Evidence from a meta-analysis" 5292: 3035: 995:. Peter Desaix, Eddie Johnson, Jody E. Johnson, Oksana Korol, Dean Kruse, Brandon Poe. Houston, Texas. 1510:"Troponin I elevation after elective percutaneous coronary interventions: Prevalence and risk factors" 354:(above 14 pg/mL) was found associated with an increased 5-year event rate of ischemic cardiac events ( 2585: 1365:"Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase" 1102:
Gomes, A.V; Potter, J.D.; Szczesna-Cordary, D. (2002). "The role of Troponin in muscle contraction".
845:
Relation of chronic myocardial injury and Non-ST-Segment elevation myocardial infarction to mortality
499: 464: 398: 2357: 1119:"Modulation of thin filament activation by breakdown or isoform switching of thin filament Proteins" 1039: 5585: 5525: 2666: 2579: 534: 402: 1660:"Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning" 3228: 3102: 3097: 643: 575:
Cardiac troponin T and I can be used to monitor drug and toxin-induced cardiomyocyte toxicity. .
456: 441: 394: 347: 304: 103:
or other myocardial injury that is ongoing, although the sensitivity of this measurement is low.
92: 119:
filaments in muscle tissue. In a relaxed muscle, tropomyosin blocks the attachment site for the
3186: 3015: 2655: 2645: 2599: 2352: 511: 425: 386: 3944: 3298: 1369: 355: 343: 296: 88: 4213: 2630: 1378: 698: 433: 1085: 858:
Stable high-sensitivity cardiac troponin T levels and outcomes in patients with chest pain
8: 5520: 4153: 2815: 1594: 1561: 1382: 940:
Kerr, Gillian; Ray, Gautamananda; Wu, Olivia; Stott, David J.; Langhorne, Peter (2009).
821: 786: 702: 3973: 3603: 2550: 2525: 2501: 2474: 2214: 2166: 2141: 2122: 2030: 2017: 2000: 1946: 1544: 1509: 1399: 1364: 1300: 1135: 1118: 1055: 1018: 919: 826: 722: 515: 335: 308: 178: 68: 52: 2406: 2389: 2366: 2250: 2233: 2189:
Mannu, GS (August 2014). "The non-cardiac use and significance of cardiac troponins".
2074: 2049: 1977: 1864: 1829: 1792: 1775: 1450: 1423: 1171: 5580: 5371: 3735: 3148: 3064: 2971: 2724: 2555: 2506: 2455: 2411: 2370: 2325: 2321: 2290: 2286: 2255: 2206: 2171: 2114: 2079: 2022: 1981: 1938: 1934: 1903: 1868: 1833: 1797: 1752: 1722: 1681: 1640: 1599: 1581: 1531: 1490: 1455: 1404: 1345: 1292: 1251: 1210: 1175: 1140: 1067: 1059: 1006: 996: 971: 963: 911: 903: 830: 808: 714: 677: 616: 503: 413: 2575: 2126: 2034: 1950: 1304: 923: 126:, thus preventing contraction. When the muscle cell is stimulated to contract by an 5319: 4443: 3798: 3793: 2764: 2545: 2537: 2496: 2486: 2445: 2401: 2362: 2317: 2282: 2245: 2218: 2198: 2161: 2153: 2106: 2069: 2061: 2012: 1973: 1930: 1895: 1860: 1825: 1787: 1712: 1671: 1658:
Henry CR, Satran D, Lindgren B, Adkinson C, Nicholson CI, Henry TD (January 2006).
1630: 1589: 1573: 1539: 1521: 1482: 1445: 1437: 1394: 1386: 1335: 1282: 1241: 1202: 1167: 1130: 1051: 953: 893: 883: 816: 798: 726: 706: 689: 545: 475: 467:, there can also be a mismatch between oxygen demand and supply of the myocardium. 429: 139: 131: 127: 1899: 226:
binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place
5461: 4075: 3925: 3808: 3092: 2984: 1635: 1618: 1577: 1340: 1246: 1229: 558: 523: 316: 292: 276: 162: 72: 1287: 1270: 888: 871: 5424: 5287: 3984: 3815: 3324: 3243: 3049: 3025: 2343:
Hamm CW. (2001). "Acute coronary syndromes. The diagnostic role of troponins".
2157: 2065: 1999:
Fleming SM, O'Gorman T, Finn J, Grimes H, Daly K, Morrison JJ (November 2000).
1717: 1701:"Cardiovascular manifestations of moderate to severe carbon monoxide poisoning" 1700: 1486: 803: 562: 479: 417: 382: 320: 76: 1526: 1441: 220:
binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex
5574: 5488: 5483: 4448: 4318: 4267: 4217: 4157: 4079: 4047: 3988: 3774: 3293: 3114: 2622: 2491: 2450: 2433: 2202: 2110: 1699:
Satran D, Henry CR, Adkinson C, Nicholson CI, Bracha Y, Henry TD (May 2005).
1585: 1535: 1063: 1010: 967: 907: 812: 471: 421: 370: 80: 761: 5332: 4387: 4142: 3686: 3278: 2793: 2746: 2559: 2510: 2459: 2415: 2374: 2259: 2210: 2175: 2118: 2083: 2026: 1985: 1907: 1872: 1837: 1801: 1771: 1756: 1726: 1685: 1676: 1659: 1644: 1603: 1494: 1459: 1408: 1349: 1179: 1144: 1071: 1038:
Gillis, Todd E.; Marshall, Christian R.; Tibbits, Glen F. (December 2007).
975: 915: 898: 718: 569: 554: 470:
Chemotherapy agents can exert toxic effects on the heart (examples include
378: 5304: 5282: 2329: 2294: 1942: 1296: 1255: 1214: 1101: 990: 36: 5478: 5429: 5299: 5189: 4519: 3963: 3918: 3837: 3759: 3307: 3143: 3118: 2937: 2908: 2709: 608: 572:, elevated troponin levels indicate some degree of myofibrillary damage. 491: 487: 437: 406: 374: 324: 197: 189: 147: 123: 112: 84: 2526:"A Review of Causes and Systemic Approach to Cardiac Troponin Elevation" 2390:"Cardiac troponin assays: a view from the clinical chemistry laboratory" 1390: 710: 5530: 5449: 5439: 5327: 4438: 4417: 4183: 4120: 4115: 4110: 4090: 4065: 4053: 4039: 4034: 4029: 4024: 4019: 4014: 4009: 4004: 3999: 3861: 3743: 3732: 3718: 3334: 3213: 3174: 3169: 3059: 3020: 2994: 2989: 2959: 2954: 2949: 2877: 2810: 2788: 2640: 658: 653: 648: 351: 300: 288: 284: 269: 265: 223: 217: 211: 166: 64: 60: 56: 2541: 1206: 958: 941: 785:
Strandberg, Love S.; Roos, Andreas; Holzmann, Martin J. (2021-01-01).
681: 630:
immunoassay methods available on many different immunoassay platforms.
153: 5359: 5354: 5349: 5309: 5147: 5142: 5137: 4495: 4475: 4130: 4125: 4105: 4100: 4095: 4085: 3994: 3898: 3832: 3218: 3123: 3109: 3069: 2979: 2895: 2847: 2842: 2759: 2677: 1090: 856:
A Roos, N Bandstein, M Lundbäck, O Hammarsten, R Ljung, MJ. Holzmann
549: 495: 483: 201: 96: 1227: 5473: 5434: 5366: 5339: 5206: 5194: 5069: 5064: 4505: 4500: 4422: 3856: 3851: 3208: 3179: 3139: 1619:"Elevated cardiac troponin measurements in critically ill patients" 1269:
Antman EM, Tanasijevic MJ, Thompson B, et al. (October 1996).
541: 527: 486:). Several toxins and venoms can also lead to heart muscle injury ( 2001:"Cardiac troponin I in pre-eclampsia and gestational hypertension" 1885: 5500: 5454: 5344: 5274: 5243: 5173: 5168: 5132: 5127: 5122: 5089: 5059: 5054: 5049: 5044: 4729: 4661: 4656: 4651: 4646: 4641: 4533: 4470: 3958: 3903: 3844: 3827: 3788: 3274: 3223: 2928: 2852: 1507: 1428: 424:. Troponins are commonly increased in several procedures such as 2591: 1558: 5419: 5401: 5396: 5391: 5386: 5376: 5211: 5104: 5099: 5084: 5079: 4991: 4937: 4902: 4877: 4872: 4867: 4862: 4852: 4847: 4837: 4822: 4817: 4699: 4694: 4689: 4601: 4591: 4571: 4556: 4551: 4546: 4541: 4407: 4178: 4173: 3930: 3596: 3591: 3581: 3359: 3164: 2918: 2050:"Raised cardiac troponins: troponin is raised in pre-eclampsia" 460: 214:
binds to calcium ions to produce a conformational change in TnI
193: 143: 120: 100: 2096: 1920: 1742: 1192: 315:
levels of other cardiac biomarkers are also relevant, such as
5444: 5216: 5199: 5036: 5031: 5021: 5016: 4981: 4971: 4961: 4946: 4927: 4917: 4912: 4897: 4892: 4887: 4882: 4857: 4842: 4832: 4827: 4812: 4807: 4787: 4782: 4777: 4772: 4767: 4762: 4757: 4752: 4747: 4742: 4737: 4709: 4704: 4671: 4666: 4636: 4631: 4611: 4606: 4586: 4576: 4491: 4369: 4364: 4359: 4354: 4349: 4344: 4339: 4334: 4329: 4324: 4308: 4303: 4298: 4293: 4288: 4283: 4278: 4273: 4248: 4243: 4238: 4233: 4228: 4223: 4203: 4198: 4193: 4188: 4168: 4163: 3873: 3803: 3752: 3749: 3746: 3738: 3727: 3724: 3721: 3706: 3701: 3696: 3691: 3663: 3653: 3638: 3571: 3561: 3541: 3516: 3511: 3496: 3486: 3481: 3476: 3471: 3466: 3461: 3446: 3400: 3395: 3390: 3380: 3375: 3370: 3349: 3344: 3339: 3329: 3316: 2923: 2913: 2835: 2830: 2825: 2820: 2307: 1998: 1769: 872:"Fourth Universal Definition of Myocardial Infarction (2018)" 732: 280: 185: 136: 116: 1698: 5545: 5540: 5535: 5495: 5466: 5381: 5258: 5253: 5248: 5152: 4802: 4797: 4792: 4719: 4714: 4581: 4463: 4458: 4453: 3913: 3908: 3866: 3779: 3769: 3764: 3658: 3648: 3643: 3633: 3623: 3618: 3613: 3608: 3531: 3456: 3451: 3441: 3436: 3431: 3426: 3421: 3416: 2872: 2803: 2798: 2739: 2734: 2729: 2719: 2714: 1963: 1814: 1657: 1317: 869: 2387: 1116: 2473:
Smith, Joe S.; Varga, Anita; Schober, Karsten E. (2020).
1421: 1268: 1040:"Functional and evolutionary relationships of troponin C" 686: 2388:
Melanson SE, Tanasijevic MJ, Jarolim P (October 2007).
2139: 942:"Elevated troponin after a stroke: a systematic review" 526:
strain results in increased wall tension and may cause
455:
Troponins are increased in around 40% of patients with
2272: 2231: 784: 184:
Troponin is a component of thin filaments (along with
1850: 1037: 412:
Heart injury with increased troponins also occurs in
1617:
Lim W, Qushmaq I, Devereaux PJ, et al. (2006).
1422:
Ammann P, Pfisterer M, Fehr T, Rickli H (May 2004).
1158:
Sarko J, Pollack CV Jr (2002). "Cardiac troponins".
1616: 762:"Troponin - Understand the Test & Your Results" 2232:Zethelius B, Johnston N, Venge P (February 2006). 615:Due to patent regulations, a single manufacturer ( 2523: 2472: 860:J Am Coll Cardiol, 70 (18) (2017), pp. 2226-2236, 150:formation, and contraction of the muscle begins. 5572: 3273: 2432:Collinson PO, Boa FG, Gaze DC (September 2001). 2431: 1770:Khan NA, Hemmelgarn BR, Tonelli M, Thompson CR, 1738: 1736: 1472: 568:In hypertensive disorders of pregnancy such as 207:Individual subunits serve different functions: 1363:Kristjansson RP, et al. (February 2016). 939: 369:Troponins are also increased in patients with 3259: 2607: 876:Journal of the American College of Cardiology 2427: 2425: 2381: 2225: 2090: 2041: 1992: 1957: 1879: 1844: 1808: 1763: 1733: 1692: 1651: 1610: 1466: 1362: 1157: 405:, or infiltrative disorders such as cardiac 2140:Lippi G, Lavie CJ, Sanchis-Gomar F (2020). 1914: 670: 3266: 3252: 2614: 2600: 2524:Patil, H.; Vaidya, O.; Bogart, D. (2011). 1023:: CS1 maint: location missing publisher ( 2578:at the U.S. National Library of Medicine 2549: 2500: 2490: 2449: 2422: 2405: 2356: 2249: 2165: 2073: 2016: 1791: 1716: 1675: 1634: 1593: 1543: 1525: 1449: 1398: 1339: 1286: 1245: 1134: 957: 897: 887: 843:A Roos, U Sartipy, R Ljung, MJ. Holzmann 820: 802: 607:Cardiac troponin T and I are measured by 447: 342:In patients with non-severe asymptomatic 95:. Blood troponin levels may be used as a 2342: 2047: 847:Am J Cardiol, 122 (2018), pp. 1989-1995, 152: 35: 5573: 935: 933: 230:Smooth muscle does not have troponin. 3247: 2595: 2188: 1117:Marston, S.B.; Redwood, C.S. (2003). 988: 520:chronic obstructive pulmonary disease 259: 3000:Connective tissue in skeletal muscle 626:A host of diagnostic companies make 111:Troponin is attached to the protein 2699: 930: 115:and lies within the groove between 13: 2434:"Measurement of cardiac troponins" 2018:10.1111/j.1471-0528.2000.tb11658.x 1136:10.1161/01.RES.0000105088.06696.17 1056:10.1152/physiolgenomics.00197.2007 561:. Troponins are also increased in 438:percutaneous coronary intervention 360:percutaneous coronary intervention 291:to differentiate between unstable 14: 5597: 2621: 2569: 2407:10.1161/CIRCULATIONAHA.107.722975 2251:10.1161/CIRCULATIONAHA.105.570762 1793:10.1161/CIRCULATIONAHA.105.560128 791:American Journal of Medicine Open 581: 3894:Wiskott–Aldrich syndrome protein 1106:. No. 54. pp. 323–333. 590:marker to detect the condition. 5115:Microtubule organising proteins 3031:Excitation–contraction coupling 2517: 2479:Frontiers in Veterinary Science 2466: 2336: 2301: 2266: 2182: 2133: 1552: 1501: 1415: 1356: 1311: 1262: 1221: 1186: 1151: 1110: 1095: 1078: 1031: 494:, and venom from jellyfish and 2099:Expert Opin Drug Metab Toxicol 982: 863: 850: 837: 778: 754: 737: 364:coronary artery bypass surgery 299:(heart attack) in people with 264:Subtypes of troponin (cardiac 1: 5162:Microtubule severing proteins 2367:10.1016/S0049-3848(01)00299-7 1978:10.1016/S0009-8981(01)00392-8 1900:10.1016/j.amjcard.2004.05.050 1865:10.1016/S0002-9149(00)01382-5 1830:10.1016/S0002-9149(99)00020-X 1172:10.1016/S0736-4679(02)00463-8 664: 593: 518:, and acute exacerbations of 172: 3822:actin depolymerizing factors 2322:10.1016/0022-2828(89)90680-9 2287:10.1016/0002-8703(87)90645-4 1935:10.1016/0140-6736(92)92262-E 1636:10.1001/archinte.166.22.2446 1578:10.1016/j.eclinm.2023.101875 1566:The Lancet eClinicalMedicine 1341:10.1161/CIR.0000000000000134 749:Dorland's Medical Dictionary 602: 329:supraventricular tachycardia 287:). They are measured in the 7: 5300:Plakoglobin (gamma catenin) 1288:10.1056/NEJM199610313351802 889:10.1016/j.jacc.2018.08.1038 637: 391:hypertrophic cardiomyopathy 254: 233: 146:'s binding to actin causes 106: 30:to detect myocardial damage 10: 5602: 3036:Sliding filament mechanism 2158:10.1016/j.pcad.2020.03.001 2066:10.1136/bmj.329.7457.111-a 1718:10.1016/j.jacc.2005.01.044 1487:10.1016/j.ajem.2007.05.031 1424:"Raised cardiac troponins" 1247:10.1093/clinchem/43.8.1379 804:10.1016/j.ajmo.2021.100001 161:Troponin is found in both 5556: 5513: 5412: 5318: 5273: 5182: 5161: 5113: 4936: 4728: 4680: 4532: 4518: 4484: 4431: 4400: 4380: 4259: 4141: 3972: 3954: 3943: 3886: 3679: 3358: 3315: 3306: 3292: 3285: 3199: 3157: 3132: 3085: 3078: 3048: 3008: 2970: 2894: 2861: 2784: 2777: 2755: 2690: 2676: 2665: 2654: 2629: 1527:10.1016/j.ihj.2016.11.319 1442:10.1136/bmj.328.7447.1028 989:Betts, J. Gordon (2013). 500:Carbon monoxide poisoning 465:gastrointestinal bleeding 420:and internal or external 399:peripartum cardiomyopathy 26: 21: 5526:Prokaryotic cytoskeleton 2580:Medical Subject Headings 2492:10.3389/fvets.2020.00531 2451:10.1258/0004563011901109 2203:10.1177/0036933014540090 2191:Scottish Medical Journal 2111:10.1517/17425255.1.4.715 992:Anatomy & physiology 946:Cerebrovascular Diseases 535:end-stage kidney disease 403:Takotsubo cardiomyopathy 51:, is a complex of three 3229:Fukutin-related protein 644:Calcium-binding protein 442:radiofrequency ablation 395:ventricular hypertrophy 348:coronary artery disease 305:acute coronary syndrome 93:acute coronary syndrome 67:) that are integral to 3187:Sarcoplasmic reticulum 3016:Neuromuscular junction 2924:elastic filament/titin 2646:Vascular smooth muscle 2048:Morton A (July 2004). 1677:10.1001/jama.295.4.398 1044:Physiological Genomics 512:pulmonary hypertension 448:Non-cardiac conditions 387:dilated cardiomyopathy 274:sensitive and specific 158: 41: 4146:(hard alpha-keratins) 3977:(soft alpha-keratins) 2919:thick filament/myosin 1370:Nature Communications 434:atrial septal defects 430:heart transplantation 356:myocardial infarction 344:aortic valve stenosis 297:myocardial infarction 156: 89:myocardial infarction 39: 5561:cytoskeletal defects 5521:Major sperm proteins 1705:J. Am. Coll. Cardiol 1514:Indian Heart Journal 540:Strenuous endurance 327:(for example due to 3974:Epithelial keratins 2914:thin filament/actin 2900:(a, i, and h bands; 2588:at Lab Tests Online 2146:Prog Cardiovasc Dis 1391:10.1038/ncomms10572 1383:2016NatCo...710572K 1201:(39): 13516–13525. 711:10.1038/nature01780 703:2003Natur.424...35T 53:regulatory proteins 2438:Ann. Clin. Biochem 2310:J Mol Cell Cardiol 1859:(3): 369–71, A10. 766:labtestsonline.org 516:pulmonary embolism 457:critical illnesses 309:coronary vasospasm 260:Cardiac conditions 159: 69:muscle contraction 42: 5568: 5567: 5509: 5508: 5269: 5268: 4514: 4513: 4396: 4395: 3939: 3938: 3882: 3881: 3241: 3240: 3237: 3236: 3195: 3194: 3149:Myosatellite cell 3065:Intercalated disc 3044: 3043: 2972:Connective tissue 2890: 2889: 2886: 2885: 2853:Synemin/desmuslin 2773: 2772: 2542:10.1002/clc.20983 2316:(12): 1349–1353. 1774:(November 2005). 1623:Arch. Intern. Med 1475:Am. J. Emerg. Med 1334:(25): e344–e426. 1207:10.1021/bi980280j 1129:(12): 1170–1178. 1002:978-1-947172-04-3 959:10.1159/000226773 882:(18): 2231–2264. 617:Roche Diagnostics 524:right ventricular 504:cyanide poisoning 414:cardiac contusion 97:diagnostic marker 34: 33: 5593: 4530: 4529: 3970: 3969: 3952: 3951: 3313: 3312: 3304: 3303: 3290: 3289: 3268: 3261: 3254: 3245: 3244: 3083: 3082: 2866: 2782: 2781: 2765:Laminin, alpha 2 2697: 2696: 2688: 2687: 2674: 2673: 2663: 2662: 2616: 2609: 2602: 2593: 2592: 2564: 2563: 2553: 2521: 2515: 2514: 2504: 2494: 2470: 2464: 2463: 2453: 2444:(Pt 5): 423–49. 2429: 2420: 2419: 2409: 2385: 2379: 2378: 2360: 2340: 2334: 2333: 2305: 2299: 2298: 2281:(6): 1333–1344. 2270: 2264: 2263: 2253: 2229: 2223: 2222: 2186: 2180: 2179: 2169: 2137: 2131: 2130: 2094: 2088: 2087: 2077: 2045: 2039: 2038: 2020: 1996: 1990: 1989: 1966:Clin. Chim. Acta 1961: 1955: 1954: 1918: 1912: 1911: 1883: 1877: 1876: 1848: 1842: 1841: 1812: 1806: 1805: 1795: 1767: 1761: 1760: 1740: 1731: 1730: 1720: 1696: 1690: 1689: 1679: 1655: 1649: 1648: 1638: 1614: 1608: 1607: 1597: 1556: 1550: 1549: 1547: 1529: 1505: 1499: 1498: 1470: 1464: 1463: 1453: 1436:(7447): 1028–9. 1419: 1413: 1412: 1402: 1360: 1354: 1353: 1343: 1325: 1315: 1309: 1308: 1290: 1266: 1260: 1259: 1249: 1240:(8): 1379–1385. 1225: 1219: 1218: 1190: 1184: 1183: 1155: 1149: 1148: 1138: 1114: 1108: 1107: 1099: 1093: 1082: 1076: 1075: 1035: 1029: 1028: 1022: 1014: 986: 980: 979: 961: 937: 928: 927: 901: 891: 867: 861: 854: 848: 841: 835: 834: 824: 806: 782: 776: 775: 773: 772: 758: 752: 741: 735: 731:; rendered with 730: 684: 674: 510:In both primary 476:cyclophosphamide 350:, the increased 334:Coronary artery 249: 132:calcium channels 128:action potential 49:troponin complex 19: 18: 5601: 5600: 5596: 5595: 5594: 5592: 5591: 5590: 5586:Muscular system 5571: 5570: 5569: 5564: 5552: 5505: 5408: 5314: 5265: 5178: 5157: 5109: 4932: 4724: 4676: 4522: 4510: 4480: 4427: 4392: 4376: 4260:Ungrouped alpha 4255: 4145: 4137: 3976: 3962: 3956: 3946: 3935: 3878: 3675: 3354: 3296: 3281: 3272: 3242: 3233: 3201: 3191: 3153: 3128: 3074: 3051: 3040: 3004: 2966: 2901: 2899: 2882: 2862: 2857: 2769: 2751: 2692: 2681: 2668: 2657: 2650: 2632: 2625: 2620: 2572: 2567: 2536:(12): 723–728. 2522: 2518: 2471: 2467: 2430: 2423: 2386: 2382: 2358:10.1.1.500.6908 2341: 2337: 2306: 2302: 2271: 2267: 2230: 2226: 2187: 2183: 2138: 2134: 2095: 2091: 2046: 2042: 2011:(11): 1417–20. 1997: 1993: 1962: 1958: 1919: 1915: 1884: 1880: 1849: 1845: 1813: 1809: 1786:(20): 3088–96. 1768: 1764: 1745:Can. J. Cardiol 1741: 1734: 1697: 1693: 1656: 1652: 1629:(22): 2446–54. 1615: 1611: 1557: 1553: 1506: 1502: 1471: 1467: 1420: 1416: 1361: 1357: 1323: 1316: 1312: 1275:N. Engl. J. Med 1267: 1263: 1226: 1222: 1191: 1187: 1156: 1152: 1115: 1111: 1100: 1096: 1083: 1079: 1036: 1032: 1016: 1015: 1003: 987: 983: 938: 931: 868: 864: 855: 851: 842: 838: 783: 779: 770: 768: 760: 759: 755: 742: 738: 697:(6944): 35–41. 676: 675: 671: 667: 640: 605: 596: 584: 559:dermatomyositis 450: 426:cardiac surgery 317:creatine kinase 283:muscle damage ( 262: 257: 247: 236: 175: 163:skeletal muscle 109: 73:skeletal muscle 17: 16:Protein complex 12: 11: 5: 5599: 5589: 5588: 5583: 5566: 5565: 5557: 5554: 5553: 5551: 5550: 5549: 5548: 5543: 5538: 5533: 5523: 5517: 5515: 5511: 5510: 5507: 5506: 5504: 5503: 5498: 5493: 5492: 5491: 5486: 5476: 5471: 5470: 5469: 5459: 5458: 5457: 5452: 5447: 5442: 5437: 5432: 5427: 5425:Corneodesmosin 5416: 5414: 5410: 5409: 5407: 5406: 5405: 5404: 5399: 5394: 5389: 5384: 5379: 5374: 5364: 5363: 5362: 5357: 5352: 5342: 5337: 5336: 5335: 5324: 5322: 5316: 5315: 5313: 5312: 5307: 5302: 5297: 5296: 5295: 5285: 5279: 5277: 5271: 5270: 5267: 5266: 5264: 5263: 5262: 5261: 5256: 5251: 5241: 5240: 5239: 5234: 5229: 5224: 5219: 5209: 5204: 5203: 5202: 5192: 5186: 5184: 5180: 5179: 5177: 5176: 5171: 5165: 5163: 5159: 5158: 5156: 5155: 5150: 5145: 5140: 5135: 5130: 5125: 5119: 5117: 5111: 5110: 5108: 5107: 5102: 5097: 5092: 5087: 5082: 5077: 5072: 5067: 5062: 5057: 5052: 5047: 5040: 5039: 5034: 5029: 5024: 5019: 5014: 5009: 5004: 4999: 4994: 4989: 4984: 4979: 4974: 4969: 4964: 4959: 4954: 4949: 4942: 4940: 4934: 4933: 4931: 4930: 4925: 4920: 4915: 4910: 4905: 4900: 4895: 4890: 4885: 4880: 4875: 4870: 4865: 4860: 4855: 4850: 4845: 4840: 4835: 4830: 4825: 4820: 4815: 4810: 4805: 4800: 4795: 4790: 4785: 4780: 4775: 4770: 4765: 4760: 4755: 4750: 4745: 4740: 4734: 4732: 4726: 4725: 4723: 4722: 4717: 4712: 4707: 4702: 4697: 4692: 4686: 4684: 4678: 4677: 4675: 4674: 4669: 4664: 4659: 4654: 4649: 4644: 4639: 4634: 4629: 4624: 4619: 4614: 4609: 4604: 4599: 4594: 4589: 4584: 4579: 4574: 4569: 4564: 4559: 4554: 4549: 4544: 4538: 4536: 4527: 4516: 4515: 4512: 4511: 4509: 4508: 4503: 4498: 4492:Nuclear lamins 4488: 4486: 4482: 4481: 4479: 4478: 4473: 4468: 4467: 4466: 4461: 4456: 4446: 4441: 4435: 4433: 4429: 4428: 4426: 4425: 4420: 4415: 4410: 4404: 4402: 4398: 4397: 4394: 4393: 4391: 4390: 4384: 4382: 4378: 4377: 4375: 4374: 4373: 4372: 4367: 4362: 4357: 4352: 4347: 4342: 4337: 4332: 4327: 4314: 4313: 4312: 4311: 4306: 4301: 4296: 4291: 4286: 4281: 4276: 4263: 4261: 4257: 4256: 4254: 4253: 4252: 4251: 4246: 4241: 4236: 4231: 4226: 4209: 4208: 4207: 4206: 4201: 4196: 4191: 4186: 4181: 4176: 4171: 4166: 4149: 4147: 4139: 4138: 4136: 4135: 4134: 4133: 4128: 4123: 4118: 4113: 4108: 4103: 4098: 4093: 4088: 4071: 4070: 4069: 4068: 4058: 4057: 4056: 4044: 4043: 4042: 4037: 4032: 4027: 4022: 4017: 4012: 4007: 4002: 3997: 3980: 3978: 3967: 3949: 3941: 3940: 3937: 3936: 3934: 3933: 3928: 3923: 3922: 3921: 3916: 3911: 3901: 3896: 3890: 3888: 3884: 3883: 3880: 3879: 3877: 3876: 3871: 3870: 3869: 3864: 3854: 3849: 3848: 3847: 3842: 3841: 3840: 3835: 3818: 3816:Arp2/3 complex 3813: 3812: 3811: 3806: 3801: 3796: 3785: 3784: 3783: 3782: 3777: 3772: 3767: 3757: 3756: 3755: 3741: 3730: 3711: 3710: 3709: 3704: 3699: 3694: 3683: 3681: 3677: 3676: 3674: 3673: 3672: 3671: 3666: 3661: 3656: 3651: 3646: 3641: 3636: 3631: 3626: 3621: 3616: 3611: 3601: 3600: 3599: 3594: 3586: 3585: 3584: 3576: 3575: 3574: 3566: 3565: 3564: 3559: 3551: 3550: 3549: 3544: 3536: 3535: 3534: 3526: 3525: 3524: 3519: 3514: 3506: 3505: 3504: 3499: 3491: 3490: 3489: 3484: 3479: 3474: 3469: 3464: 3459: 3454: 3449: 3444: 3439: 3434: 3429: 3424: 3419: 3411: 3410: 3409: 3403: 3398: 3393: 3388: 3383: 3378: 3373: 3364: 3362: 3356: 3355: 3353: 3352: 3347: 3342: 3337: 3332: 3327: 3321: 3319: 3310: 3301: 3294:Microfilaments 3287: 3283: 3282: 3271: 3270: 3263: 3256: 3248: 3239: 3238: 3235: 3234: 3232: 3231: 3226: 3221: 3216: 3211: 3205: 3203: 3197: 3196: 3193: 3192: 3190: 3189: 3184: 3183: 3182: 3172: 3167: 3161: 3159: 3155: 3154: 3152: 3151: 3146: 3136: 3134: 3130: 3129: 3127: 3126: 3121: 3112: 3107: 3106: 3105: 3100: 3089: 3087: 3080: 3076: 3075: 3073: 3072: 3067: 3062: 3056: 3054: 3046: 3045: 3042: 3041: 3039: 3038: 3033: 3028: 3026:Muscle spindle 3023: 3018: 3012: 3010: 3006: 3005: 3003: 3002: 2997: 2992: 2987: 2982: 2976: 2974: 2968: 2967: 2965: 2964: 2963: 2962: 2957: 2952: 2941: 2940: 2934: 2933: 2932: 2931: 2926: 2921: 2916: 2905: 2903: 2902:z and m lines) 2892: 2891: 2888: 2887: 2884: 2883: 2881: 2880: 2875: 2869: 2867: 2859: 2858: 2856: 2855: 2850: 2845: 2840: 2839: 2838: 2833: 2828: 2823: 2818: 2808: 2807: 2806: 2801: 2791: 2785: 2779: 2775: 2774: 2771: 2770: 2768: 2767: 2762: 2756: 2753: 2752: 2750: 2749: 2744: 2743: 2742: 2737: 2732: 2727: 2722: 2717: 2706: 2704: 2694: 2685: 2671: 2660: 2652: 2651: 2649: 2648: 2643: 2637: 2635: 2627: 2626: 2619: 2618: 2611: 2604: 2596: 2590: 2589: 2583: 2571: 2570:External links 2568: 2566: 2565: 2516: 2465: 2421: 2400:(18): e501–4. 2380: 2335: 2300: 2265: 2224: 2181: 2152:(3): 390–391. 2132: 2089: 2040: 1991: 1972:(1–2): 27–33. 1956: 1913: 1888:Am. J. Cardiol 1878: 1853:Am. J. Cardiol 1843: 1818:Am. J. Cardiol 1807: 1762: 1751:(12): 1212–8. 1732: 1691: 1670:(4): 398–402. 1650: 1609: 1551: 1520:(3): 322–324. 1500: 1465: 1414: 1355: 1310: 1281:(18): 1342–9. 1261: 1220: 1185: 1150: 1109: 1094: 1077: 1030: 1001: 981: 952:(3): 220–226. 929: 862: 849: 836: 777: 753: 736: 668: 666: 663: 662: 661: 656: 651: 646: 639: 636: 632: 631: 624: 619:) distributes 604: 601: 595: 592: 583: 582:Prognostic use 580: 563:rhabdomyolysis 488:scorpion venom 480:5-fluorouracil 449: 446: 418:defibrillation 383:cardiomyopathy 321:kidney failure 261: 258: 256: 253: 235: 232: 228: 227: 221: 215: 174: 171: 167:cardiac muscle 108: 105: 77:cardiac muscle 32: 31: 28: 24: 23: 15: 9: 6: 4: 3: 2: 5598: 5587: 5584: 5582: 5579: 5578: 5576: 5563: 5562: 5555: 5547: 5544: 5542: 5539: 5537: 5534: 5532: 5529: 5528: 5527: 5524: 5522: 5519: 5518: 5516: 5512: 5502: 5499: 5497: 5494: 5490: 5487: 5485: 5482: 5481: 5480: 5477: 5475: 5472: 5468: 5465: 5464: 5463: 5460: 5456: 5453: 5451: 5448: 5446: 5443: 5441: 5438: 5436: 5433: 5431: 5428: 5426: 5423: 5422: 5421: 5418: 5417: 5415: 5411: 5403: 5400: 5398: 5395: 5393: 5390: 5388: 5385: 5383: 5380: 5378: 5375: 5373: 5370: 5369: 5368: 5365: 5361: 5358: 5356: 5353: 5351: 5348: 5347: 5346: 5343: 5341: 5338: 5334: 5331: 5330: 5329: 5326: 5325: 5323: 5321: 5317: 5311: 5308: 5306: 5305:Delta catenin 5303: 5301: 5298: 5294: 5291: 5290: 5289: 5286: 5284: 5283:Alpha catenin 5281: 5280: 5278: 5276: 5272: 5260: 5257: 5255: 5252: 5250: 5247: 5246: 5245: 5242: 5238: 5235: 5233: 5230: 5228: 5225: 5223: 5220: 5218: 5215: 5214: 5213: 5210: 5208: 5205: 5201: 5198: 5197: 5196: 5193: 5191: 5188: 5187: 5185: 5181: 5175: 5172: 5170: 5167: 5166: 5164: 5160: 5154: 5151: 5149: 5146: 5144: 5141: 5139: 5136: 5134: 5131: 5129: 5126: 5124: 5121: 5120: 5118: 5116: 5112: 5106: 5103: 5101: 5098: 5096: 5093: 5091: 5088: 5086: 5083: 5081: 5078: 5076: 5073: 5071: 5068: 5066: 5063: 5061: 5058: 5056: 5053: 5051: 5048: 5046: 5043:cytoplasmic: 5042: 5041: 5038: 5035: 5033: 5030: 5028: 5025: 5023: 5020: 5018: 5015: 5013: 5010: 5008: 5005: 5003: 5000: 4998: 4995: 4993: 4990: 4988: 4985: 4983: 4980: 4978: 4975: 4973: 4970: 4968: 4965: 4963: 4960: 4958: 4955: 4953: 4950: 4948: 4944: 4943: 4941: 4939: 4935: 4929: 4926: 4924: 4921: 4919: 4916: 4914: 4911: 4909: 4906: 4904: 4901: 4899: 4896: 4894: 4891: 4889: 4886: 4884: 4881: 4879: 4876: 4874: 4871: 4869: 4866: 4864: 4861: 4859: 4856: 4854: 4851: 4849: 4846: 4844: 4841: 4839: 4836: 4834: 4831: 4829: 4826: 4824: 4821: 4819: 4816: 4814: 4811: 4809: 4806: 4804: 4801: 4799: 4796: 4794: 4791: 4789: 4786: 4784: 4781: 4779: 4776: 4774: 4771: 4769: 4766: 4764: 4761: 4759: 4756: 4754: 4751: 4749: 4746: 4744: 4741: 4739: 4736: 4735: 4733: 4731: 4727: 4721: 4718: 4716: 4713: 4711: 4708: 4706: 4703: 4701: 4698: 4696: 4693: 4691: 4688: 4687: 4685: 4683: 4679: 4673: 4670: 4668: 4665: 4663: 4660: 4658: 4655: 4653: 4650: 4648: 4645: 4643: 4640: 4638: 4635: 4633: 4630: 4628: 4625: 4623: 4620: 4618: 4615: 4613: 4610: 4608: 4605: 4603: 4600: 4598: 4595: 4593: 4590: 4588: 4585: 4583: 4580: 4578: 4575: 4573: 4570: 4568: 4565: 4563: 4560: 4558: 4555: 4553: 4550: 4548: 4545: 4543: 4540: 4539: 4537: 4535: 4531: 4528: 4526: 4521: 4517: 4507: 4504: 4502: 4499: 4497: 4493: 4490: 4489: 4487: 4483: 4477: 4474: 4472: 4469: 4465: 4462: 4460: 4457: 4455: 4452: 4451: 4450: 4449:Neurofilament 4447: 4445: 4442: 4440: 4437: 4436: 4434: 4430: 4424: 4421: 4419: 4416: 4414: 4411: 4409: 4406: 4405: 4403: 4399: 4389: 4386: 4385: 4383: 4379: 4371: 4368: 4366: 4363: 4361: 4358: 4356: 4353: 4351: 4348: 4346: 4343: 4341: 4338: 4336: 4333: 4331: 4328: 4326: 4323: 4322: 4321: 4320: 4319:chromosome 12 4316: 4315: 4310: 4307: 4305: 4302: 4300: 4297: 4295: 4292: 4290: 4287: 4285: 4282: 4280: 4277: 4275: 4272: 4271: 4270: 4269: 4268:chromosome 17 4265: 4264: 4262: 4258: 4250: 4247: 4245: 4242: 4240: 4237: 4235: 4232: 4230: 4227: 4225: 4222: 4221: 4220: 4219: 4218:chromosome 12 4215: 4211: 4210: 4205: 4202: 4200: 4197: 4195: 4192: 4190: 4187: 4185: 4182: 4180: 4177: 4175: 4172: 4170: 4167: 4165: 4162: 4161: 4160: 4159: 4158:chromosome 17 4155: 4151: 4150: 4148: 4144: 4143:Hair keratins 4140: 4132: 4129: 4127: 4124: 4122: 4119: 4117: 4114: 4112: 4109: 4107: 4104: 4102: 4099: 4097: 4094: 4092: 4089: 4087: 4084: 4083: 4082: 4081: 4080:chromosome 12 4077: 4073: 4072: 4067: 4064: 4063: 4062: 4059: 4055: 4052: 4051: 4050: 4049: 4048:chromosome 12 4045: 4041: 4038: 4036: 4033: 4031: 4028: 4026: 4023: 4021: 4018: 4016: 4013: 4011: 4008: 4006: 4003: 4001: 3998: 3996: 3993: 3992: 3991: 3990: 3989:chromosome 17 3986: 3982: 3981: 3979: 3975: 3971: 3968: 3965: 3960: 3953: 3950: 3948: 3945:Intermediate 3942: 3932: 3929: 3927: 3924: 3920: 3917: 3915: 3912: 3910: 3907: 3906: 3905: 3902: 3900: 3897: 3895: 3892: 3891: 3889: 3885: 3875: 3872: 3868: 3865: 3863: 3860: 3859: 3858: 3855: 3853: 3850: 3846: 3843: 3839: 3836: 3834: 3831: 3830: 3829: 3826: 3825: 3824: 3823: 3819: 3817: 3814: 3810: 3807: 3805: 3802: 3800: 3797: 3795: 3792: 3791: 3790: 3787: 3786: 3781: 3778: 3776: 3773: 3771: 3768: 3766: 3763: 3762: 3761: 3758: 3754: 3751: 3748: 3745: 3742: 3740: 3737: 3734: 3731: 3729: 3726: 3723: 3720: 3717: 3716: 3715: 3712: 3708: 3705: 3703: 3700: 3698: 3695: 3693: 3690: 3689: 3688: 3685: 3684: 3682: 3678: 3670: 3667: 3665: 3662: 3660: 3657: 3655: 3652: 3650: 3647: 3645: 3642: 3640: 3637: 3635: 3632: 3630: 3627: 3625: 3622: 3620: 3617: 3615: 3612: 3610: 3607: 3606: 3605: 3602: 3598: 3595: 3593: 3590: 3589: 3587: 3583: 3580: 3579: 3577: 3573: 3570: 3569: 3567: 3563: 3560: 3558: 3555: 3554: 3552: 3548: 3545: 3543: 3540: 3539: 3537: 3533: 3530: 3529: 3527: 3523: 3520: 3518: 3515: 3513: 3510: 3509: 3507: 3503: 3500: 3498: 3495: 3494: 3492: 3488: 3485: 3483: 3480: 3478: 3475: 3473: 3470: 3468: 3465: 3463: 3460: 3458: 3455: 3453: 3450: 3448: 3445: 3443: 3440: 3438: 3435: 3433: 3430: 3428: 3425: 3423: 3420: 3418: 3415: 3414: 3412: 3407: 3404: 3402: 3399: 3397: 3394: 3392: 3389: 3387: 3384: 3382: 3379: 3377: 3374: 3372: 3369: 3368: 3366: 3365: 3363: 3361: 3357: 3351: 3348: 3346: 3343: 3341: 3338: 3336: 3333: 3331: 3328: 3326: 3323: 3322: 3320: 3318: 3314: 3311: 3309: 3305: 3302: 3300: 3295: 3291: 3288: 3284: 3280: 3276: 3269: 3264: 3262: 3257: 3255: 3250: 3249: 3246: 3230: 3227: 3225: 3222: 3220: 3217: 3215: 3212: 3210: 3207: 3206: 3204: 3198: 3188: 3185: 3181: 3178: 3177: 3176: 3173: 3171: 3168: 3166: 3163: 3162: 3160: 3156: 3150: 3147: 3145: 3141: 3138: 3137: 3135: 3131: 3125: 3122: 3120: 3116: 3115:Microfilament 3113: 3111: 3108: 3104: 3101: 3099: 3096: 3095: 3094: 3091: 3090: 3088: 3084: 3081: 3077: 3071: 3068: 3066: 3063: 3061: 3058: 3057: 3055: 3053: 3047: 3037: 3034: 3032: 3029: 3027: 3024: 3022: 3019: 3017: 3014: 3013: 3011: 3007: 3001: 2998: 2996: 2993: 2991: 2988: 2986: 2983: 2981: 2978: 2977: 2975: 2973: 2969: 2961: 2958: 2956: 2953: 2951: 2948: 2947: 2946: 2943: 2942: 2939: 2936: 2935: 2930: 2927: 2925: 2922: 2920: 2917: 2915: 2912: 2911: 2910: 2907: 2906: 2904: 2897: 2893: 2879: 2876: 2874: 2871: 2870: 2868: 2865: 2860: 2854: 2851: 2849: 2846: 2844: 2841: 2837: 2834: 2832: 2829: 2827: 2824: 2822: 2819: 2817: 2814: 2813: 2812: 2809: 2805: 2802: 2800: 2797: 2796: 2795: 2792: 2790: 2787: 2786: 2783: 2780: 2778:Intracellular 2776: 2766: 2763: 2761: 2758: 2757: 2754: 2748: 2745: 2741: 2738: 2736: 2733: 2731: 2728: 2726: 2723: 2721: 2718: 2716: 2713: 2712: 2711: 2708: 2707: 2705: 2702: 2698: 2695: 2693:extracellular 2689: 2686: 2684: 2679: 2675: 2672: 2670: 2664: 2661: 2659: 2653: 2647: 2644: 2642: 2639: 2638: 2636: 2634: 2628: 2624: 2623:Muscle tissue 2617: 2612: 2610: 2605: 2603: 2598: 2597: 2594: 2587: 2584: 2581: 2577: 2574: 2573: 2561: 2557: 2552: 2547: 2543: 2539: 2535: 2531: 2527: 2520: 2512: 2508: 2503: 2498: 2493: 2488: 2484: 2480: 2476: 2469: 2461: 2457: 2452: 2447: 2443: 2439: 2435: 2428: 2426: 2417: 2413: 2408: 2403: 2399: 2395: 2391: 2384: 2376: 2372: 2368: 2364: 2359: 2354: 2350: 2346: 2339: 2331: 2327: 2323: 2319: 2315: 2311: 2304: 2296: 2292: 2288: 2284: 2280: 2276: 2269: 2261: 2257: 2252: 2247: 2244:(8): 1071–8. 2243: 2239: 2235: 2228: 2220: 2216: 2212: 2208: 2204: 2200: 2196: 2192: 2185: 2177: 2173: 2168: 2163: 2159: 2155: 2151: 2147: 2143: 2136: 2128: 2124: 2120: 2116: 2112: 2108: 2105:(4): 715–25. 2104: 2100: 2093: 2085: 2081: 2076: 2071: 2067: 2063: 2060:(7457): 111. 2059: 2055: 2051: 2044: 2036: 2032: 2028: 2024: 2019: 2014: 2010: 2006: 2002: 1995: 1987: 1983: 1979: 1975: 1971: 1967: 1960: 1952: 1948: 1944: 1940: 1936: 1932: 1929:(8821): 726. 1928: 1924: 1917: 1909: 1905: 1901: 1897: 1893: 1889: 1882: 1874: 1870: 1866: 1862: 1858: 1854: 1847: 1839: 1835: 1831: 1827: 1824:(7): 1085–9. 1823: 1819: 1811: 1803: 1799: 1794: 1789: 1785: 1781: 1777: 1773: 1766: 1758: 1754: 1750: 1746: 1739: 1737: 1728: 1724: 1719: 1714: 1711:(9): 1513–6. 1710: 1706: 1702: 1695: 1687: 1683: 1678: 1673: 1669: 1665: 1661: 1654: 1646: 1642: 1637: 1632: 1628: 1624: 1620: 1613: 1605: 1601: 1596: 1591: 1587: 1583: 1579: 1575: 1571: 1567: 1563: 1555: 1546: 1541: 1537: 1533: 1528: 1523: 1519: 1515: 1511: 1504: 1496: 1492: 1488: 1484: 1481:(3): 331–41. 1480: 1476: 1469: 1461: 1457: 1452: 1447: 1443: 1439: 1435: 1431: 1430: 1425: 1418: 1410: 1406: 1401: 1396: 1392: 1388: 1384: 1380: 1376: 1372: 1371: 1366: 1359: 1351: 1347: 1342: 1337: 1333: 1329: 1322: 1314: 1306: 1302: 1298: 1294: 1289: 1284: 1280: 1276: 1272: 1265: 1257: 1253: 1248: 1243: 1239: 1235: 1231: 1224: 1216: 1212: 1208: 1204: 1200: 1196: 1189: 1181: 1177: 1173: 1169: 1165: 1161: 1160:J. Emerg. Med 1154: 1146: 1142: 1137: 1132: 1128: 1124: 1120: 1113: 1105: 1098: 1092: 1088: 1087: 1081: 1073: 1069: 1065: 1061: 1057: 1053: 1049: 1045: 1041: 1034: 1026: 1020: 1012: 1008: 1004: 998: 994: 993: 985: 977: 973: 969: 965: 960: 955: 951: 947: 943: 936: 934: 925: 921: 917: 913: 909: 905: 900: 899:10044/1/73052 895: 890: 885: 881: 877: 873: 866: 859: 853: 846: 840: 832: 828: 823: 818: 814: 810: 805: 800: 796: 792: 788: 781: 767: 763: 757: 751: 750: 745: 740: 734: 728: 724: 720: 716: 712: 708: 704: 700: 696: 692: 691: 683: 679: 673: 669: 660: 657: 655: 652: 650: 647: 645: 642: 641: 635: 629: 625: 622: 618: 614: 613: 612: 610: 600: 591: 587: 579: 576: 573: 571: 566: 564: 560: 556: 551: 547: 543: 538: 536: 531: 529: 525: 521: 517: 513: 508: 505: 501: 497: 493: 489: 485: 481: 477: 473: 472:anthracycline 468: 466: 462: 458: 453: 445: 443: 439: 435: 432:, closure of 431: 427: 423: 422:cardioversion 419: 415: 410: 408: 404: 400: 396: 392: 388: 384: 380: 376: 372: 371:heart failure 367: 365: 361: 357: 353: 349: 346:and no overt 345: 340: 337: 332: 330: 326: 322: 318: 312: 310: 306: 302: 298: 294: 290: 286: 282: 278: 275: 271: 267: 252: 244: 240: 231: 225: 222: 219: 216: 213: 210: 209: 208: 205: 203: 199: 195: 191: 187: 182: 180: 170: 168: 164: 155: 151: 149: 145: 141: 138: 133: 129: 125: 122: 118: 114: 104: 102: 98: 94: 90: 86: 82: 81:smooth muscle 78: 74: 70: 66: 62: 58: 54: 50: 46: 38: 29: 25: 20: 5558: 5333:Dystroglycan 5288:Beta catenin 4520:Microtubules 4388:Beta-keratin 4317: 4266: 4212: 4152: 4074: 4060: 4046: 3983: 3820: 3713: 3687:Tropomodulin 3279:cytoskeleton 3093:Muscle fiber 2944: 2863: 2794:Dystrobrevin 2747:Dystroglycan 2533: 2530:Clin Cardiol 2529: 2519: 2482: 2478: 2468: 2441: 2437: 2397: 2393: 2383: 2351:(1): 63–69. 2348: 2344: 2338: 2313: 2309: 2303: 2278: 2274: 2268: 2241: 2237: 2227: 2197:(3): 172–8. 2194: 2190: 2184: 2149: 2145: 2135: 2102: 2098: 2092: 2057: 2053: 2043: 2008: 2004: 1994: 1969: 1965: 1959: 1926: 1922: 1916: 1894:(5): 696–8. 1891: 1887: 1881: 1856: 1852: 1846: 1821: 1817: 1810: 1783: 1779: 1765: 1748: 1744: 1708: 1704: 1694: 1667: 1663: 1653: 1626: 1622: 1612: 1569: 1565: 1554: 1517: 1513: 1503: 1478: 1474: 1468: 1433: 1427: 1417: 1374: 1368: 1358: 1331: 1327: 1313: 1278: 1274: 1264: 1237: 1233: 1223: 1198: 1195:Biochemistry 1194: 1188: 1166:(1): 57–65. 1163: 1159: 1153: 1126: 1122: 1112: 1103: 1097: 1084: 1080: 1050:(1): 16–27. 1047: 1043: 1033: 991: 984: 949: 945: 879: 875: 865: 857: 852: 844: 839: 794: 790: 780: 769:. Retrieved 765: 756: 747: 739: 694: 688: 672: 633: 627: 620: 606: 597: 588: 585: 577: 574: 570:preeclampsia 567: 555:polymyositis 539: 533:People with 532: 509: 469: 454: 451: 411: 379:pericarditis 368: 341: 333: 313: 263: 245: 241: 237: 229: 206: 183: 176: 160: 110: 48: 44: 43: 5479:Plakophilin 5430:Desmoplakin 5190:Tau protein 3964:Cytokeratin 3760:Tropomyosin 3308:Myofilament 3144:Muscle cell 3119:Myofilament 2938:Tropomyosin 2909:Myofilament 2710:Sarcoglycan 2394:Circulation 2345:Thromb. Res 2275:Am. Heart J 2238:Circulation 1780:Circulation 1328:Circulation 609:immunoassay 492:snake venom 407:amyloidosis 375:myocarditis 325:tachycardia 198:tropomyosin 190:tropomyosin 148:crossbridge 124:crossbridge 113:tropomyosin 85:myocarditis 5575:Categories 5559:See also: 5531:Crescentin 5450:Periplakin 5440:Envoplakin 5328:Dystrophin 4945:axonemal: 4439:Internexin 4418:Peripherin 3214:Telethonin 3175:Sarcolemma 3170:Sarcoplasm 3103:extrafusal 3098:intrafusal 3060:Myocardium 3021:Motor unit 2995:Endomysium 2990:Perimysium 2878:Caveolin 3 2811:Syntrophin 2789:Dystrophin 2641:Calmodulin 1572:: 101875. 1234:Clin. Chem 797:: 100001. 771:2019-04-18 744:"troponin" 665:References 659:Troponin T 654:Troponin I 649:Troponin C 550:triathlons 496:centipedes 393:or (left) 385:, such as 352:troponin T 301:chest pain 285:myocardium 277:indicators 224:Troponin I 218:Troponin T 212:Troponin C 173:Physiology 79:, but not 65:troponin T 61:troponin I 57:troponin C 5148:Centrin 3 5143:Centrin 2 5138:Centrin 1 4476:Syncoilin 4381:Not alpha 3947:filaments 3899:Fibrillin 3219:Dysferlin 3202:ungrouped 3124:Sarcomere 3110:Myofibril 3070:Nebulette 2980:Epimysium 2896:Sarcomere 2848:Dysbindin 2843:Syncoilin 2760:Sarcospan 2691:Membrane/ 2678:Costamere 2586:Troponins 2353:CiteSeerX 1586:2589-5370 1536:0019-4832 1377:: 10572. 1123:Circ. Res 1091:eMedicine 1086:Troponins 1064:1094-8341 1019:cite book 1011:898069394 968:1421-9786 908:0735-1097 831:244507759 813:2667-0364 685:​; 611:methods. 603:Detection 546:marathons 484:cisplatin 323:. Severe 202:sarcomere 140:filaments 47:, or the 5581:Troponin 5514:Nonhuman 5474:Vinculin 5435:Dystonin 5367:Spectrin 5340:Utrophin 5320:Membrane 5275:Catenins 5207:Stathmin 5195:Dynactin 5075:DYNC2LI1 5070:DYNC1LI2 5065:DYNC1LI1 4730:Kinesins 4534:Tubulins 4423:Vimentin 3955:Type 1/2 3857:Profilin 3852:Gelsolin 3714:Troponin 3275:Proteins 3209:Myotilin 3180:T-tubule 3140:Myoblast 2985:Fascicle 2945:Troponin 2864:related: 2667:Skeletal 2656:Striated 2576:Troponin 2560:22120679 2511:33062647 2460:11587122 2416:17967982 2375:11567671 2260:16490824 2211:24934496 2176:32169400 2127:38299373 2119:16863435 2084:15242925 2035:23517519 2027:11117772 1986:11282091 1951:32856946 1908:15342317 1873:11165984 1838:10190525 1802:16286604 1757:15494773 1727:15862427 1686:16434630 1645:17159009 1604:36915288 1595:10006443 1495:18358946 1460:15117768 1409:26838040 1350:25249585 1305:25524575 1180:12217473 1145:14670832 1072:17940202 976:19571535 924:52110825 916:30153967 822:11256254 719:12840750 638:See also 594:Subunits 544:such as 542:exercise 528:ischemia 522:(COPD), 459:such as 255:Research 234:Subunits 107:Function 45:Troponin 22:Troponin 5501:PLEKHA7 5455:Plectin 5420:Plakins 5345:Ankyrin 5244:Dynamin 5174:Spastin 5169:Katanin 5133:CAMSAP3 5128:CAMSAP2 5123:CAMSAP1 5095:DYNLRB2 5090:DYNLRB1 5060:DYNC1I2 5055:DYNC1I1 5050:DYNC2H1 5045:DYNC1H1 4938:Dyneins 4662:TUBGCP6 4657:TUBGCP5 4652:TUBGCP4 4647:TUBGCP3 4642:TUBGCP2 4471:Synemin 4214:type II 4076:type II 3959:Keratin 3904:Filamin 3845:Destrin 3828:Cofilin 3789:Actinin 3360:Myosins 3277:of the 3224:Fukutin 3050:Cardiac 3009:General 2929:nebulin 2551:6652696 2502:7481330 2485:: 531. 2330:2632816 2295:3591601 2219:9010300 2167:7127395 1943:1355820 1772:Levin A 1545:5485429 1400:4742860 1379:Bibcode 1297:8857017 1256:9267317 1215:9753437 727:2174019 699:Bibcode 179:calcium 27:Purpose 5402:SPTBN5 5397:SPTBN4 5392:SPTBN2 5387:SPTBN1 5377:SPTAN1 5212:Tektin 5105:DYNLT3 5100:DYNLT1 5085:DYNLL2 5080:DYNLL1 5027:DNALI1 5012:DNAH17 5007:DNAH14 5002:DNAH13 4997:DNAH12 4992:DNAH11 4987:DNAH10 4908:KIF26B 4903:KIF26A 4878:KIF21B 4873:KIF21A 4868:KIF20B 4863:KIF20A 4853:KIF18B 4848:KIF18A 4838:KIF16B 4823:KIF13B 4818:KIF13A 4617:TUBB4Q 4602:TUBB2C 4597:TUBB2B 4592:TUBB2A 4572:TUBA4A 4567:TUBA3E 4562:TUBA3D 4557:TUBA3C 4552:TUBA1C 4547:TUBA1B 4542:TUBA1A 4485:Type 5 4444:Nestin 4432:Type 4 4408:Desmin 4401:Type 3 4154:type I 3985:type I 3931:TRIOBP 3597:MYO18B 3592:MYO18A 3588:XVIII 3582:MYO15A 3317:Actins 3200:Other/ 3165:Desmin 3052:muscle 2669:muscle 2658:muscle 2633:muscle 2631:Smooth 2582:(MeSH) 2558:  2548:  2509:  2499:  2458:  2414:  2373:  2355:  2328:  2293:  2258:  2217:  2209:  2174:  2164:  2125:  2117:  2082:  2075:449874 2072:  2033:  2025:  1984:  1949:  1941:  1923:Lancet 1906:  1871:  1836:  1800:  1755:  1725:  1684:  1643:  1602:  1592:  1584:  1542:  1534:  1493:  1458:  1451:403831 1448:  1407:  1397:  1348:  1303:  1295:  1254:  1213:  1178:  1143:  1070:  1062:  1009:  999:  974:  966:  922:  914:  906:  829:  819:  811:  725:  717:  690:Nature 482:, and 461:sepsis 293:angina 272:) are 194:myosin 144:Myosin 121:myosin 101:stroke 63:, and 5462:Talin 5445:MACF1 5413:Other 5372:SPTA1 5237:TEKT5 5232:TEKT4 5227:TEKT3 5222:TEKT2 5217:TEKT1 5200:DCTN1 5183:Other 5037:DNAL4 5032:DNAL1 5022:DNAI2 5017:DNAI1 4982:DNAH9 4977:DNAH8 4972:DNAH7 4967:DNAH6 4962:DNAH5 4957:DNAH3 4952:DNAH2 4947:DNAH1 4928:KIFC3 4923:KIFC2 4918:KIFC1 4913:KIF27 4898:KIF25 4893:KIF24 4888:KIF23 4883:KIF22 4858:KIF19 4843:KIF17 4833:KIF15 4828:KIF14 4813:KIF12 4808:KIF11 4788:KIF5C 4783:KIF5B 4778:KIF5A 4773:KIF4B 4768:KIF4A 4763:KIF3C 4758:KIF3B 4753:KIF2C 4748:KIF2A 4743:KIF1B 4738:KIF1A 4710:MAP1B 4705:MAP1A 4672:TUBE1 4667:TUBD1 4637:TUBG2 4632:TUBG1 4627:TUBB8 4622:TUBB6 4612:TUBB4 4607:TUBB3 4587:TUBB1 4577:TUBA8 3926:Espin 3887:Other 3874:Titin 3680:Other 3669:MYLL1 3664:MYLK2 3654:MYLIP 3639:MYL6B 3572:MYO10 3562:MYO9B 3557:MYO9A 3547:MYO7B 3542:MYO7A 3522:MYO5C 3517:MYO5B 3512:MYO5A 3502:MYO3B 3497:MYO3A 3487:MYH16 3482:MYH15 3477:MYH14 3472:MYH13 3467:MYH11 3462:MYH10 3447:MYH7B 3406:MYO1H 3401:MYO1G 3396:MYO1F 3391:MYO1E 3386:MYO1D 3381:MYO1C 3376:MYO1B 3371:MYO1A 3286:Human 3158:Other 3133:Cells 3086:Fiber 2215:S2CID 2123:S2CID 2031:S2CID 1947:S2CID 1324:(PDF) 1301:S2CID 920:S2CID 827:S2CID 733:PyMOL 723:S2CID 440:, or 362:, or 336:stent 289:blood 281:heart 186:actin 137:actin 117:actin 5546:ParM 5541:MreB 5536:FtsZ 5496:ACF7 5489:PKP2 5484:PKP1 5467:TLN1 5382:SPTB 5360:ANK3 5355:ANK2 5350:ANK1 5259:DNM3 5254:DNM2 5249:DNM1 5153:PCM1 4803:KIF9 4798:KIF7 4793:KIF6 4720:MAP4 4715:MAP2 4682:MAPs 4582:TUBB 4525:MAPs 4523:and 4464:NEFH 4459:NEFM 4454:NEFL 4413:GFAP 4061:none 3919:FLNC 3914:FLNB 3909:FLNA 3659:MYLK 3649:MYL9 3644:MYL7 3634:MYL6 3629:MYL5 3624:MYL4 3619:MYL3 3614:MYL2 3609:MYL1 3538:VII 3532:MYO6 3493:III 3457:MYH9 3452:MYH8 3442:MYH7 3437:MYH6 3432:MYH4 3427:MYH3 3422:MYH2 3417:MYH1 3299:ABPs 3297:and 3079:Both 2873:NOS1 2740:SGCZ 2735:SGCG 2730:SGCE 2725:SGCD 2720:SGCB 2715:SGCA 2683:DAPC 2556:PMID 2507:PMID 2456:PMID 2412:PMID 2371:PMID 2326:PMID 2291:PMID 2256:PMID 2207:PMID 2172:PMID 2115:PMID 2080:PMID 2023:PMID 2005:BJOG 1982:PMID 1939:PMID 1904:PMID 1869:PMID 1834:PMID 1798:PMID 1753:PMID 1723:PMID 1682:PMID 1664:JAMA 1641:PMID 1600:PMID 1582:ISSN 1532:ISSN 1491:PMID 1456:PMID 1405:PMID 1346:PMID 1293:PMID 1252:PMID 1211:PMID 1176:PMID 1141:PMID 1104:Life 1068:PMID 1060:ISSN 1025:link 1007:OCLC 997:ISBN 972:PMID 964:ISSN 912:PMID 904:ISSN 809:ISSN 715:PMID 682:1J1E 628:cTnI 621:cTnT 428:and 377:and 295:and 268:and 188:and 165:and 99:for 91:and 75:and 5310:GAN 5293:APC 4700:EB3 4695:EB2 4690:EB1 4496:A/C 4179:33B 4174:33A 3578:XV 3553:IX 3528:VI 3413:II 2701:DAP 2546:PMC 2538:doi 2497:PMC 2487:doi 2446:doi 2402:doi 2398:116 2363:doi 2349:103 2318:doi 2283:doi 2279:113 2246:doi 2242:113 2199:doi 2162:PMC 2154:doi 2107:doi 2070:PMC 2062:doi 2058:329 2054:BMJ 2013:doi 2009:107 1974:doi 1970:306 1931:doi 1927:340 1896:doi 1861:doi 1826:doi 1788:doi 1784:112 1713:doi 1672:doi 1668:295 1631:doi 1627:166 1590:PMC 1574:doi 1540:PMC 1522:doi 1483:doi 1446:PMC 1438:doi 1434:328 1429:BMJ 1395:PMC 1387:doi 1336:doi 1332:130 1283:doi 1279:335 1242:doi 1203:doi 1168:doi 1131:doi 1089:at 1052:doi 954:doi 894:hdl 884:doi 817:PMC 799:doi 795:1–6 746:at 707:doi 695:424 678:PDB 557:or 548:or 502:or 498:). 366:). 303:or 279:of 71:in 5577:: 4506:B2 4501:B1 4494:: 4370:80 4365:79 4360:78 4355:77 4350:76 4345:75 4340:74 4335:73 4330:72 4325:71 4309:40 4304:39 4299:28 4294:27 4289:26 4284:25 4279:24 4274:23 4249:86 4244:85 4239:84 4234:83 4229:82 4224:81 4204:38 4199:37 4194:36 4189:35 4184:34 4169:32 4164:31 4121:6C 4116:6B 4111:6A 4091:2A 4066:21 4054:18 4040:20 4035:19 4030:17 4025:16 4020:15 4015:14 4010:13 4005:12 4000:10 3604:LC 3568:X 3508:V 3367:I 3350:G2 3345:G1 3340:C1 3330:A2 3325:A1 2836:G2 2831:G1 2826:B2 2821:B1 2554:. 2544:. 2534:34 2532:. 2528:. 2505:. 2495:. 2481:. 2477:. 2454:. 2442:38 2440:. 2436:. 2424:^ 2410:. 2396:. 2392:. 2369:. 2361:. 2347:. 2324:. 2314:21 2312:. 2289:. 2277:. 2254:. 2240:. 2236:. 2213:. 2205:. 2195:59 2193:. 2170:. 2160:. 2150:63 2148:. 2144:. 2121:. 2113:. 2101:. 2078:. 2068:. 2056:. 2052:. 2029:. 2021:. 2007:. 2003:. 1980:. 1968:. 1945:. 1937:. 1925:. 1902:. 1892:94 1890:. 1867:. 1857:87 1855:. 1832:. 1822:83 1820:. 1796:. 1782:. 1778:. 1749:20 1747:. 1735:^ 1721:. 1709:45 1707:. 1703:. 1680:. 1666:. 1662:. 1639:. 1625:. 1621:. 1598:. 1588:. 1580:. 1570:58 1568:. 1564:. 1538:. 1530:. 1518:69 1516:. 1512:. 1489:. 1479:26 1477:. 1454:. 1444:. 1432:. 1426:. 1403:. 1393:. 1385:. 1373:. 1367:. 1344:. 1330:. 1326:. 1299:. 1291:. 1277:. 1273:. 1250:. 1238:43 1236:. 1232:. 1209:. 1199:37 1197:. 1174:. 1164:23 1162:. 1139:. 1127:93 1125:. 1121:. 1066:. 1058:. 1048:32 1046:. 1042:. 1021:}} 1017:{{ 1005:. 970:. 962:. 950:28 948:. 944:. 932:^ 918:. 910:. 902:. 892:. 880:72 878:. 874:. 825:. 815:. 807:. 793:. 789:. 764:. 721:. 713:. 705:. 693:. 680:: 565:. 514:, 490:, 478:, 474:, 444:. 436:, 416:, 409:. 401:, 397:, 389:, 358:, 248:× 204:. 142:. 130:, 87:, 59:, 4216:/ 4156:/ 4131:8 4126:7 4106:5 4101:4 4096:3 4086:1 4078:/ 3995:9 3987:/ 3966:) 3961:, 3957:( 3867:2 3862:1 3838:2 3833:1 3809:4 3804:3 3799:2 3794:1 3780:4 3775:3 3770:2 3765:1 3753:3 3750:2 3747:1 3744:I 3739:2 3736:1 3733:C 3728:3 3725:2 3722:1 3719:T 3707:4 3702:3 3697:2 3692:1 3408:) 3335:B 3267:e 3260:t 3253:v 3142:/ 3117:/ 2960:I 2955:C 2950:T 2898:/ 2816:A 2804:B 2799:A 2703:: 2680:/ 2615:e 2608:t 2601:v 2562:. 2540:: 2513:. 2489:: 2483:7 2462:. 2448:: 2418:. 2404:: 2377:. 2365:: 2332:. 2320:: 2297:. 2285:: 2262:. 2248:: 2221:. 2201:: 2178:. 2156:: 2129:. 2109:: 2103:1 2086:. 2064:: 2037:. 2015:: 1988:. 1976:: 1953:. 1933:: 1910:. 1898:: 1875:. 1863:: 1840:. 1828:: 1804:. 1790:: 1759:. 1729:. 1715:: 1688:. 1674:: 1647:. 1633:: 1606:. 1576:: 1548:. 1524:: 1497:. 1485:: 1462:. 1440:: 1411:. 1389:: 1381:: 1375:7 1352:. 1338:: 1307:. 1285:: 1258:. 1244:: 1217:. 1205:: 1182:. 1170:: 1147:. 1133:: 1074:. 1054:: 1027:) 1013:. 978:. 956:: 926:. 896:: 886:: 833:. 801:: 774:. 729:. 709:: 701:: 623:. 270:T 266:I 55:(

Index


regulatory proteins
troponin C
troponin I
troponin T
muscle contraction
skeletal muscle
cardiac muscle
smooth muscle
myocarditis
myocardial infarction
acute coronary syndrome
diagnostic marker
stroke
tropomyosin
actin
myosin
crossbridge
action potential
calcium channels
actin
filaments
Myosin
crossbridge

skeletal muscle
cardiac muscle
calcium
actin
tropomyosin

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.