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Timeline of early HIV/AIDS cases

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276:. He developed symptoms which were similar to the symptoms which David Carr developed, and he died on 28 June 1959, apparently of the same very rare kind of pneumonia that killed Carr. Many years later, Dr. Gordon R. Hennigar, who had performed the autopsy on Antonio's body, was asked whether or not he thought his patient had died of AIDS; he replied "You bet ... It was so unusual at the time. Lord knows how many cases of AIDS have been autopsied that we didn't even know had AIDS. I think it's such a strong possibility that I've often thought about getting them to send me the tissue samples." 26: 118: 265:
which was present in the tissues was similar to the strain of HIV which was found in tissue samples which were collected and analyzed in the late 1980s rather than an earlier strain of HIV (which would have mutated considerably over the course of 30 years). Ho's discovery has cast doubt on the theory
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SIV exists as distinct lineages that cluster in different species of primates. HIV-1 is most similar to the SIV found in common chimpanzees (SIVcpz) in southeastern Cameroon, giving rise to the notion that HIV-1 emerged from chimpanzees in this area. SIVcpz itself emerged in chimpanzees as the result
180:. This estimation was the result of time-scaled evolutionary models being applied to modern samples and retrieved early samples of HIV-1 (M). It had previously been estimated from the genetic differences between LEO70 and DRC60 samples and later samples that 380:
in 1964 then again in 1972 to aid the sick. She was likely directly exposed to blood from many Congolese patients, one of whom infected her. She became unwell in 1974, then returned to Denmark in 1977, with her colleagues baffled by her symptoms. She died of
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Ardouin Antonio, a 49-year-old Jamaican-born Haitian, has been suggested as a possible early AIDS case. Antonio had emigrated to the United States in 1927, and at the time of his death, he was working as a shipping clerk for a garment manufacturer in
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and preserved in paraffin. In 2008, the sample was tested by researchers, identifying partial HIV viral sequences. The specimen, named DRC60 contained a strain of HIV-1 around 88% similar to LEO70, but was found to be most closely related to
321:(M) subgroup A isolates. These two specimens are significant not only because they are the oldest known specimens of HIV-1, but because they show that the virus already had an extensive amount of genetic diversity by 1960. 361:
some time between 1962 and 1965, and died on 24 April 1976. His eight-year-old daughter had died three months earlier, and his wife died in December 1976. Tissues of Røed, his wife and daughter all tested positive for
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Keele, Brandon F.; Van Heuverswyn, Fran; Li, Yingying; Bailes, Elizabeth; Takehisa, Jun; Santiago, Mario L.; Bibollet-Ruche, Frederic; Chen, Yalu; Wain, Louise V.; Liegeois, Florian; Loul, Severin (28 July 2006).
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was recognised as a novel illness in the early 1980s. An AIDS case is classified as "early" if the death occurred before 5 June 1981, when the AIDS epidemic was formally recognized by medical professionals in the
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Herbert Heinrich was a German concert violinist who died in 1979. Tests in 1989 found that he was HIV-positive, and there has been speculation that he was infected by a sex worker who was infected by Noe.
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Faria, Nuno R.; Rambaut, Andrew; Suchard, Marc A.; Baele, Guy; Bedford, Trevor; Ward, Melissa J.; Tatem, Andrew J.; Sousa, JoĂŁo D.; Arinaminpathy, Nimalan; PĂ©pin, Jacques; Posada, David (3 October 2014).
257:. Baffled by what he had died from, doctors preserved 50 of his tissue samples for inspection. In 1990, the tissues were found to be HIV-positive. However, in 1992, a second test by AIDS researcher 1173:
Garry RF, Witte MH, Gottlieb AA, Elvin-Lewis M, Gottlieb MS, Witte CL, Alexander SS, Cole WR, Drake WL Jr (October 1988). "Documentation of an AIDS virus infection in the United States in 1968".
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Worobey, Michael; Gemmel, Marlea; Teuwen, Dirk E.; Haselkorn, Tamara; Kunstman, Kevin; Bunce, Michael; Muyembe, Jean-Jacques; Kabongo, Jean-Marie M.; et al. (2008).
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Bailes, Elizabeth; Gao, Feng; Bibollet-Ruche, Frederic; Courgnaud, Valerie; Peeters, Martine; Marx, Preston A.; Hahn, Beatrice H.; Sharp, Paul M. (13 June 2003).
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A D M Bryceson, A M Tomkins, D Ridley, D Warhurst, A Goldstone, G Bayliss, J Toswill, J Ridley. HIV-2 associated AIDS in the 1970s. Letter Lancet, 1988, ii, 221.
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infections, considered novel to the European continent, and both AIDS related conditions. Some of these cases occurred in infants considered immunocompetent.
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W. C. Saxinger; P. H. Levine; A. G. Dean; G. de The; G. Lange-Wantzin; J. Moghissi; F. Laurent; M. Hoh; R. C. Gallo; Gallo, R. C.; et al. (March 1985).
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Hennigar, G.R., Lyons, H.A. et al., Pneumocystis carinii pneumonia in an adult, American Journal of Clinical Pathology, 1961, 35(4), 353–364.
213: 76: 1823: 1642: 1592: 1540: 1391: 1936: 347:. In 1985, retroactive testing of the frozen blood serum indicated that 50 of the children had antibodies to a virus related to HIV. 83: 1750: 479: 1662: 1492: 1314: 1035: 964: 65: 220:, Belgian Congo. The isolated strain was found to be most closely related to modern genome sequences of HIV-1 (M) subgroup D. 1911: 1082: 2342: 2030: 2467: 1707: 728: 755: 1890: 1780: 143:
All known subgroups of HIV-1 and HIV-2 are thought to have entered humans as distinct cross-species transmissions of
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Zhu, Tuofu; Korber, Bette T.; Nahmias, Andre J.; Hooper, Edward; Sharp, Paul M.; Ho, David D. (5 February 1998).
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Wyatt, J. P.; Trumbull, M. L.; Evans, M.; et al. (1953). "Cytomegalic Inclusion Pneumonitis in the adult".
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printer (sometimes mistakenly referred to as a sailor) who died on 31 August 1959 following the failure of his
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by Professor Anthony Bryceson until he died of the disease in 1978. He is the first confirmed case of
208:). The sample, designated LEO70, was isolated from the plasma of "an adult Bantu male" who also had a 2481: 2449: 2437: 2390: 1966: 1275:
Fro̸land, S.S.; Jenum, P.; Lindboe, C.F.; Wefring, K.W.; Linnestad, P.J.; Böhmer, T. (11 June 1988).
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in December 1977. Her tissues were examined and tested by her colleagues and found positive in 1987.
44: 1423:"Grethe Rask reddede liv på congolesisk missionshospital, indtil mødet med ukendt virus blev fatalt" 1422: 2322: 2172: 2045: 1733: 1692: 1209: 235:
with pneumocystis pneumonia and CMV, which some authors suggest constitutes a sufficient number of
2540: 2412: 2287: 2205: 2107: 1672: 1667: 327:, a 16-year-old boy who died in 1969, is considered to be the first recorded case of AIDS in the 236: 40: 503:"Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California" 2252: 2225: 2215: 2137: 2122: 2020: 1840: 1770: 1577: 1567: 382: 281: 172:(responsible for the global pandemic) is estimated to have emerged in humans around 1920 near 2535: 2489: 2427: 2417: 2327: 2262: 1833: 1801: 1738: 1562: 1478: 2504: 2422: 2337: 2312: 2297: 2235: 2187: 2167: 2092: 2087: 2072: 1813: 1745: 1226: 910: 853: 631: 431: 258: 227:
Richard Edwin Graves Jr., a 28-year-old World War II veteran who had been stationed in the
8: 2519: 2494: 2462: 2380: 2352: 2302: 2220: 2210: 2162: 2152: 2142: 2117: 1728: 1702: 426: 152: 1230: 914: 857: 780:"HIV epidemiology. The early spread and epidemic ignition of HIV-1 in human populations" 635: 2509: 2499: 2407: 2402: 2375: 2362: 2347: 2332: 2282: 2245: 2230: 2182: 2177: 2157: 2127: 2102: 2062: 2054: 1986: 1981: 1850: 1775: 1677: 1367: 1340: 1306: 1146: 1117: 1100: 944: 874: 841: 812: 779: 720: 660: 619: 591: 558: 451: 232: 181: 1294: 2457: 2307: 2277: 2257: 2240: 2147: 2112: 2097: 2082: 2067: 1845: 1755: 1712: 1582: 1372: 1298: 1242: 1217: 1190: 1186: 1122: 1016: 981: 936: 928: 899:"An African HIV-1 sequence from 1959 and implications for the origin of the epidemic" 879: 817: 799: 712: 704: 665: 647: 596: 578: 522: 514: 471: 463: 389: 209: 1310: 1276: 1045: 2514: 2292: 2272: 2267: 2197: 2132: 1875: 1362: 1354: 1290: 1234: 1182: 1112: 1008: 973: 948: 918: 869: 861: 807: 791: 724: 696: 655: 639: 586: 570: 344: 1079: 2025: 1765: 1535: 1086: 1040: 318: 285: 228: 574: 217: 1976: 1760: 1012: 324: 1358: 2582: 1956: 1865: 1207: 1101:"Pneumocystis Infection and Cytomegaly of the Lungs in the Newborn and Adult" 1036:"How scientists discovered false evidence on the world's "first AIDS victim"" 932: 803: 708: 651: 582: 518: 467: 405: 328: 309: 250: 205: 177: 169: 132: 1238: 977: 795: 700: 684: 643: 1991: 1682: 1126: 985: 883: 821: 751: 716: 669: 600: 313: 1376: 1302: 1246: 1194: 1020: 940: 526: 475: 1895: 1796: 1587: 369: 865: 1855: 1697: 1525: 1281: 502: 246: 54:
if you can. Unsourced or poorly sourced material may be challenged and
842:"Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960" 350: 273: 254: 1961: 1860: 1557: 1505: 358: 297: 193: 173: 151:
of a recombination of two separate lineages of SIV known to infect
127: 1470: 923: 898: 216:, in 1959. At the time of the samples isolation, he was living in 1885: 1392:"After hard working days she rested by the beautiful Ebola River" 500: 449: 373: 682: 2001: 999:
Huminer, D.; Rosenfeld, J. (1987). "AIDS in the Pre-AIDS era".
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European and Developing Countries Clinical Trials Partnership
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How Long Has Virus Been Stalking Victims? 25 October 1987
1520: 1501: 1345: 1210:"Evidence for exposure to HTLV-III in Uganda before 1973" 620:"Chimpanzee reservoirs of pandemic and nonpandemic HIV-1" 312:) died, and a lymph node sample was taken and fixed with 262: 1600:
WHO disease staging system for HIV infection and disease
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List of HIV/AIDS cases and deaths registered by region
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for a clinical course suggestive of an AIDS diagnosis.
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sailor and truck driver who was probably infected in
353:(an anagram of his birth name Arne Vidar Røed) was a 557:
Sharp, Paul M.; Hahn, Beatrice H. (September 2011).
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and it is believed he was exposed to the disease in
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List of countries by HIV/AIDS adult prevalence rate
1952:
President's Emergency Plan for AIDS Relief (PEPFAR)
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Joint United Nations Programme on HIV/AIDS (UNAIDS)
961: 1341:"Sailors and star-bursts, and the arrival of HIV" 1277:"HIV-1 infection in Norwegian family before 1970" 501:Centers for Disease Control (CDC) (3 July 1981). 450:Centers for Disease Control (CDC) (5 June 1981). 223:Possible cases of AIDS from this period include: 2580: 998: 1551:National Addiction and HIV Data Archive Program 752:"Aids: Origin of pandemic 'was 1920s Kinshasa'" 749: 50:Please review the contents of the article and 1486: 835: 833: 831: 1643:Diffuse infiltrative lymphocytosis syndrome 1074: 1072: 563:Cold Spring Harbor Perspectives in Medicine 507:MMWR. Morbidity and Mortality Weekly Report 456:MMWR. Morbidity and Mortality Weekly Report 339:Researchers drew blood from 75 children in 266:that David Carr's death was caused by AIDS. 192:The earliest known sample of HIV-1 is from 184:had jumped into humans in 1908 ± 10 years. 1876:People With AIDS Self-Empowerment Movement 1493: 1479: 828: 366:type O, in an epidemiology study in 1988. 1366: 1334: 1332: 1116: 922: 873: 811: 659: 590: 556: 1069: 743: 408:, where he lived between 1956 and 1966. 280:Researchers begin to note the spread of 1098: 2581: 1338: 1329: 1139: 1033: 965:American Journal of Clinical Pathology 559:"Origins of HIV and the AIDS pandemic" 1912:Discredited HIV/AIDS origins theories 1474: 1467:, Sydney: Angus & Robertson, 1996 1154:from the original on 11 February 2009 685:"Hybrid origin of SIV in chimpanzees" 452:"Pneumocystis pneumonia--Los Angeles" 164: 1317:from the original on 22 October 2016 612: 610: 552: 550: 548: 343:to serve as controls for a study of 19: 2031:The Freddie Mercury Tribute Concert 1500: 1420: 1389: 1339:Hooper, Edward (20 December 1997). 13: 750:James Gallagher (2 October 2014). 533:from the original on 18 March 2021 482:from the original on 22 April 2009 66:"Timeline of early HIV/AIDS cases" 14: 2605: 1617:Countries by AIDS prevalence rate 1457: 1433:from the original on 15 July 2021 1402:from the original on 15 July 2021 1105:The American Journal of Pathology 607: 545: 231:. Graves died on 26 July 1952 in 2078:Democratic Republic of the Congo 1638:AIDS-defining clinical condition 1256:from the original on 4 July 2021 1187:10.1001/jama.1988.03410140097031 1140:Kolata, Gina (28 October 1987). 758:from the original on 6 June 2022 731:from the original on 25 May 2021 302:Democratic Republic of the Congo 198:Democratic Republic of the Congo 138: 116: 24: 1445: 1414: 1390:Maj, Helle (10 November 2020). 1383: 1268: 1201: 1166: 1133: 1092: 1060: 1034:Connor, Steve (24 March 1995). 1027: 992: 955: 296:In 1960, a woman in modern-day 1044:. pp. 2–3. Archived from 1001:Reviews of Infectious Diseases 890: 770: 676: 494: 443: 394:Hospital for Tropical Diseases 52:add the appropriate references 1: 1947:Misconceptions about HIV/AIDS 1927:International AIDS Conference 1881:HIV/AIDS in the porn industry 1824:Discrimination against people 1295:10.1016/S0140-6736(88)92164-2 437: 145:Simian immunodeficiency virus 1807:Catholic Church and HIV/AIDS 1688:HIV Drug Resistance Database 7: 2108:CĂ´te d'Ivoire (Ivory Coast) 1942:Media portrayal of HIV/AIDS 1871:List of HIV-positive people 1099:Hamperl, H (10 June 1955). 575:10.1101/cshperspect.a006841 422:List of HIV-positive people 415: 37:reliable medical references 10: 2610: 2008:Reports from the Holocaust 1932:International AIDS Society 1922:Elton John AIDS Foundation 1421:Maj, Helle (9 June 2020). 2558: 2528: 2480: 2448: 2398: 2389: 2361: 2196: 2053: 2044: 1967:Treatment Action Campaign 1904: 1789: 1721: 1683:Tuberculosis co-infection 1625: 1546:disease progression rates 1513: 1359:10.1136/bmj.315.7123.1689 261:found that the strain of 43:or relies too heavily on 1693:Innate resistance to HIV 1663:Neurocognitive disorders 1085:22 December 2007 at the 1013:10.1093/clinids/9.6.1102 376:surgeon who traveled to 334: 291: 237:opportunistic infections 187: 2014:AIDS–Holocaust metaphor 1997:Gay Men's Health Crisis 1673:Opportunistic infection 1239:10.1126/science.2983417 796:10.1126/science.1256739 701:10.1126/science.1080657 644:10.1126/science.1126531 392:man was treated at the 1841:HIV-affected community 1781:HIV and homosexual men 383:pneumocystis pneumonia 282:Pneumocystis pneumonia 2021:Silence=Death Project 1819:Criminal transmission 1739:Multiple sex partners 1089:retrieved 15 May 2008 978:10.1093/ajcp/23.4.353 147:(SIV) from primates. 2343:United Arab Emirates 1814:Circumcision and HIV 1771:City of Hope Patient 1531:structure and genome 432:Timeline of HIV/AIDS 2589:History of HIV/AIDS 1891:AIDS Memorial Quilt 1703:HIV-positive people 1353:(7123): 1689–1691. 1289:(8598): 1344–1345. 1231:1985Sci...227.1036S 1225:(4690): 1036–1038. 1048:on 24 February 2005 915:1998Natur.391..594Z 866:10.1038/nature07390 858:2008Natur.455..661W 636:2006Sci...313..523K 427:History of HIV/AIDS 176:, then part of the 153:red-capped mangabey 2594:Medicine timelines 2468:Dominican Republic 1851:HIV/AIDS denialism 1776:Women and HIV/AIDS 1766:The London Patient 1633:Signs and symptoms 1541:CDC classification 1427:Kristeligt Dagblad 1396:globalhealth.ku.dk 1147:The New York Times 253:; he succumbed to 233:Memphis, Tennessee 165:Early 20th century 2576: 2575: 2554: 2553: 2476: 2475: 1957:The SING Campaign 1846:HIV/AIDS activism 1834:Cost of treatment 1756:Timothy Ray Brown 1751:World AIDS Museum 909:(6667): 594–597. 630:(5786): 523–526. 210:Sickle cell trait 125: 124: 101: 2601: 2546:Papua New Guinea 2396: 2395: 2051: 2050: 1495: 1488: 1481: 1472: 1471: 1452: 1449: 1443: 1442: 1440: 1438: 1418: 1412: 1411: 1409: 1407: 1387: 1381: 1380: 1370: 1336: 1327: 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Index

reliable medical references
verification
primary sources
add the appropriate references
removed
"Timeline of early HIV/AIDS cases"
news
newspapers
books
scholar
JSTOR
HIV/AIDS
United States
Simian immunodeficiency virus
red-capped mangabey
Cercopithecus
HIV-1 group M
Kinshasa
Belgian Congo
HIV-1 group M
Kinshasa
Democratic Republic of the Congo
Zaire
Belgian Congo
Sickle cell trait
G6PDD
LĂ©opoldville
Solomon Islands
Memphis, Tennessee
opportunistic infections

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