582:
559:
1110:. The antileukemic activity of tigecycline can be attributed to the inhibition of mitochondrial protein translation in eukaryotic cells. Leukemic cells have an increased dependence on mitochondrial function, causing a heightened sensitivity to tigecycline. Tigecycline has also shown anti-cancer properties against several other kinds of tumors, including non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, and
1252:. In rats or rabbits, tigecycline crossed the placenta and was found in the fetal tissues, and is associated with slightly lower birth weights as well as slower bone ossification. Even though it was not considered teratogenic, tigecycline should be avoided unless benefits outweigh the risks. In addition, its use during childhood can cause yellow-grey-brown discoloration of the teeth and should not be used unless necessary.
31:
1336:. These antibiotics were the first new drugs of the tetracycline class to be reported since the discovery of minocycline in 1970. The glycylcyclines were found to be active against a broad spectrum of tetracycline susceptible and resistant Gram (-) and Gram (+) aerobic and anaerobic bacteria. This initial research resulted in numerous studies being done on the antibacterial activity of various
4058:
1328:
in 1970, but antibiotic resistance to the drug began growing in prevalence throughout the 70's and 80's. While the problem of antibiotic resistance was known to scientists during the 1980s, apathy led to little federal attention given to the emerging crisis. However, by the late 1980s the worldwide
1287:
in
September 2010, for tigecycline regarding an increased risk of death compared to other appropriate treatment. As a result of increase in total death rate (cause is unknown) in individuals taking this drug, tigecycline is reserved for situations in which alternative treatment is not suitable. The
1270:
mortality in patients treated for hospital-acquired pneumonia, especially ventilator-associated pneumonia (a non-approved use), but also in patients with complicated skin and skin structure infections, complicated intra-abdominal infections and diabetic foot infection. Increased mortality was in
1379:
Studies have shown that tigecycline binds to the 70S ribosome with 5 fold and >100 fold greater affinity than minocycline and tetracycline, respectively . As previously mentioned, tigecycline still binds to the A site of the 30S ribosomal subunit, however the binding of the novel antibiotic
800:
Tigecycline is used to treat different kinds of bacterial infections, including complicated skin and structure infections, complicated intra-abdominal infections and community-acquired bacterial pneumonia. Tigecycline is a glycylcycline antibiotic that covers MRSA and Gram-negative organisms:
1303:: Since both tigecycline and warfarin bind to serum or plasma proteins, there is potential for protein-binding interactions, such that one drug will have more effect than the other. Although dose adjustment is not necessary, INR and prothrombin time should be monitored if given concurrently.
651:
1442:
it is approved in adults and in children from the age of eight years for the treatment of complicated skin and soft tissue infections (excluding diabetic foot infections) and complicated intra-abdominal infections in situations where other alternative antibiotics are not suitable.
1380:
involves substantial interactions with residues of helix H34 of that same subunit. These interactions are not observed in the binding of tetracycline. The findings indicate that tigecycline likely has a unique mechanism of action that prevents inhibition from ribosomal protection.
1340:, with extra focus being put on N,N-dimethylglycyl-amino derivatives, due to their reported potency. The aforementioned research culminated in a 1999 paper describing the discovery of a compound known as GAR-936, which would later be known as Tigecycline.
3088:
Hoffmann M, DeMaio W, Jordan RA, Talaat R, Harper D, Speth J, et al. (September 2007). "Metabolism, excretion, and pharmacokinetics of tigecycline, a first-in-class glycylcycline antibiotic, after intravenous infusion to healthy male subjects".
1761:
The selection and use of essential medicines: report of the WHO Expert
Committee on Selection and Use of Essential Medicines, 2019 (including the 21st WHO Model List of Essential Medicines and the 7th WHO Model List of Essential Medicines for
1271:
comparison to other treatment of the same types of infections. The difference was not statistically significant for any type, but mortality was numerically greater for every infection type with
Tigecycline treatment, and thus prompted a
693:
InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1
1423:
metabolite. Therefore, dose adjustments are needed for patients with severe hepatic impairment. More so, it is primarily eliminated unchanged in the feces and secondarily eliminated by the kidneys. No renal adjustments are necessary.
1126:
Tigecycline targets both Gram-positive and Gram-negative bacteria including a few key multi-drug resistant pathogens. The following represents MIC susceptibility data for a few medically significant bacterial pathogens.
1247:
Precaution is needed when taken in individuals with tetracycline hypersensitivity, pregnant women, and children. It has been found to cause fetal harm when administered during pregnancy and therefore is classified as
1437:
It is approved to treat complicated skin and soft tissue infections (cSSTI), complicated intra-abdominal infections (cIAI), and community-acquired bacterial pneumonia (CAP) in individuals 18 years and older. In the
2314:
Pournaras S, Koumaki V, Spanakis N, Gennimata V, Tsakris A (July 2016). "Current perspectives on tigecycline resistance in
Enterobacteriaceae: susceptibility testing issues and mechanisms of resistance".
2728:
Sum PE, Lee VJ, Testa RT, Hlavka JJ, Ellestad GA, Bloom JD, et al. (January 1994). "Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines".
1070:
isolates have MICs <0.25 for tigecycline The
European Society of Clinical Microbiology and Infection recommends tigecycline as a potential salvage therapy for severe and/or complicated or refractory
1239:
Rare adverse effects (<2%) include: swelling, pain, and irritation at injection site, anorexia, jaundice, hepatic dysfunction, pruritus, acute pancreatitis, and increased prothrombin time.
1186:
Tigecycline does not require dose adjustment for people with mild to moderate liver problems. However, in people with severe liver problems dosing should be decreased and closely monitored.
2476:
2443:
255:
3216:
2766:"N,N-dimethylglycyl-amido derivative of minocycline and 6-demethyl-6-desoxytetracycline, two new glycylcyclines highly effective against tetracycline-resistant gram-positive cocci"
1508:
1236:
Common side effects of tigecycline include nausea and vomiting. Nausea (26%) and vomiting (18%) tend to be mild or moderate and usually occur during the first two days of therapy.
1217:
spp. can be naturally resistant to tigecycline through the constant over-expression of such efflux pumps. In some
Enterobacteriaceae species, mutations in ribosomal genes such as
986:
bacterial pathogens, many of which are resistant to existing antibiotics. Tigecycline successfully completed phase III trials in which it was at least equal to intravenous
2601:
Church RF, Schaub RE, Weiss MJ (March 1971). "Synthesis of 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) via 9-nitro-6-demethyl-6-deoxytetracycline".
1098:
and tumor metastasis. This is a feature not unique to minocycline, with many tetracyclines exhibiting non-antibiotic clinical benefits. Tigecycline has shown
3209:
2099:
Whiteman M, Halliwell B (January 1997). "Prevention of peroxynitrite-dependent tyrosine nitration and inactivation of alpha1-antiproteinase by antibiotics".
1733:
Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert
Committee on the selection and use of essential medicines
1403:, tigecycline has been found to improve minimal inhibitory concentrations against Gram-negative and Gram-positive organisms, when compared to tetracyclines.
1332:
In 1993, researchers in the same laboratories that first synthesized minocycline created a new generation of tetracycline antibacterial agents, known as the
210:
2862:
Sum PE, Petersen P (May 1999). "Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936".
1919:
Di Bella S, Nisii C, Petrosillo N (July 2015). "Is tigecycline a suitable option for
Clostridium difficile infection? Evidence from the literature".
3202:
1613:
2444:"FDA Drug Safety Communication: Increased risk of death with Tygacil (tigecycline) compared to other antibiotics used to treat similar infections"
1086:
It is well established that tigecycline works as an effective antibiotic, however it may have other properties that are not yet fully understood.
1210:
2477:"FDA Drug Safety Communication: FDA warns of increased risk of death with IV antibacterial Tygacil (tigecycline) and approves new Boxed Warning"
1309:: Effectiveness of oral contraceptives are decreased with concurrent use due to reduction in the concentration levels of oral contraceptives.
995:
107:
2509:
Dixit D, Madduri RP, Sharma R (April 2014). "The role of tigecycline in the treatment of infections in light of the new black box warning".
1399:-dimethyglycylamido (DMG) moiety attached to the 9-position of tetracycline ring D. With structural modifications as a 9-DMG derivative of
665:
1015:
901:
818:
2815:"In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)"
3040:
Nguyen F, Starosta AL, Arenz S, Sohmen D, Dönhöfer A, Wilson DN (May 2014). "Tetracycline antibiotics and resistance mechanisms".
3194:
780:(FDA) fast-track approval and was approved on 17 June 2005. It was approved for medical use in the European Union in April 2006.
1555:
3159:"Comparative in vitro activities of tigecycline (GAR-936) and other antimicrobial agents against Stenotrophomonas maltophilia"
4012:
784:
2636:
Macdonald H, Kelly RG, Allen ES, Noble JF, Kanegis LA (September 1973). "Pharmacokinetic studies on minocycline in man".
761:. As a tetracycline derivative antibiotic, its structural modifications has expanded its therapeutic activity to include
4093:
4083:
1059:
spp. The drug is licensed for the treatment of skin and soft tissue infections as well as intra-abdominal infections.
710:
158:
4088:
2005:
Garrido-Mesa N, Zarzuelo A, Gálvez J (January 2013). "What is behind the non-antibiotic properties of minocycline?".
1825:
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1364:
with the A site of the ribosome. In addition, tigecycline has demonstrated bactericidal activity against isolates of
685:
4029:
2224:
Worasilchai N, Chindamporn A, Plongla R, Torvorapanit P, Manothummetha K, Chuleerarux N, et al. (March 2020).
1078:
Tigecycline can also be used in vulnerable populations such as immunocompromised patients or patients with cancer.
1038:
952:
Tigecycline may be used for treatment of community-acquired bacterial pneumonia caused by; penicillin susceptible
353:
240:
139:
2482:
2449:
1023:
922:
777:
577:
458:
2401:"Tigecycline-induced acute pancreatitis in a cystic fibrosis patient: A case report and literature review"
787:
in 2019. The World Health
Organization classifies tigecycline as critically important for human medicine.
3229:
1353:
538:
527:
3717:
3621:
3272:
1209:
is often caused by genetic mutations leading to an up-regulation of bacterial efflux pumps, such as the
4048:
1233:
to the class of antibiotics. Gastrointestinal (GI) symptoms are the most common reported side effect.
3961:
1803:
1756:
1728:
1589:
1349:
1003:
2136:"Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia"
1329:
threat began to be treated more seriously, which led to the renewed funding of antibiotic research.
3480:
1384:
1366:
954:
827:
770:
739:
class drug that is administered intravenously. It was developed in response to the growing rate of
554:
3224:
3133:"Tygacil 50mg powder for solution for infusion - Summary of Product Characteristics (SPC) - (eMC)"
1959:
Kaewpoowat Q, Ostrosky-Zeichner L (February 2015). "Tigecycline : a critical safety review".
4017:
1461:
Tigilyn (Marketed by Real Value therapy pharmaceuticals company in
Myanmar, Manufactured by Lyka)
1306:
1043:
938:
910:
833:
751:
728:
195:
97:
3363:
1372:
983:
979:
970:
960:
839:
766:
762:
507:
295:
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Rose WE, Rybak MJ (August 2006). "Tigecycline: first of a new class of antimicrobial agents".
1509:"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017"
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890:
851:
813:
745:
2134:
Skrtić M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, et al. (November 2011).
1584:
864:
Tigecycline is indicated for treatment of complicated intra-abdominal infections caused by;
382:
3670:
2053:
1325:
1249:
932:
916:
872:
866:
857:
845:
740:
732:
467:
315:
8:
3299:
2990:"Functional, biophysical, and structural bases for antibacterial activity of tigecycline"
2040:
Amin AR, Attur MG, Thakker GD, Patel PD, Vyas PR, Patel RN, et al. (November 1996).
1055:
373:
202:
2057:
1189:
Tigecycline does not require dose changes in people with poor kidney function or having
581:
558:
3114:
3065:
3014:
2989:
2926:
2710:
2661:
2583:
2534:
2254:
2225:
2160:
2135:
1984:
1901:
1670:
1256:
1202:
944:
884:
169:
2875:
2790:
2765:
2376:
2351:
2328:
1932:
1854:
1090:
has been shown to have anti-inflammatory and anti-apoptotic activities, inhibition of
3941:
3937:
3506:
3180:
3106:
3057:
3019:
2970:
2965:
2948:
2918:
2879:
2844:
2839:
2814:
2795:
2746:
2702:
2653:
2618:
2575:
2526:
2422:
2381:
2352:"Pharmacokinetics of tigecycline after single and multiple doses in healthy subjects"
2332:
2259:
2206:
2165:
2116:
2081:
2076:
2041:
2022:
1976:
1936:
1893:
1821:
1785:
1775:
1710:
1662:
268:
131:
3069:
2714:
2665:
2538:
1988:
1905:
1674:
1313:
However, the mechanism behind these drug interactions have not been fully analyzed.
673:
CC(C)(C)NCC(=O)Nc1cc(c2C3C4(N(C)C)C(\O)=C(\C(N)=O)C(=O)4(O)C(/O)=C3/C(=O)c2c1O)N(C)C
407:
3989:
3933:
3561:
3170:
3118:
3098:
3049:
3009:
3001:
2960:
2930:
2910:
2871:
2834:
2826:
2785:
2777:
2738:
2692:
2645:
2610:
2587:
2565:
2518:
2412:
2371:
2363:
2324:
2278:"Tigecycline : Susceptibility and Minimum Inhibitory Concentration (MIC) Data"
2277:
2249:
2241:
2196:
2155:
2147:
2108:
2071:
2061:
2014:
1968:
1928:
1885:
1811:
1765:
1736:
1702:
1654:
1482:
1107:
878:
807:
757:
594:
287:
223:
117:
48:
3249:
3132:
2367:
2185:"Evaluating the efficacy of Tigecycline to target multiple cancer-types: A Review"
4062:
3980:
3975:
3687:
3556:
3551:
2522:
2042:"A novel mechanism of action of tetracyclines: effects on nitric oxide synthases"
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2018:
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965:
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2400:
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3825:
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3697:
3692:
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3369:
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2988:
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2706:
2210:
2066:
1789:
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1333:
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1272:
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1007:
736:
570:
22:
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3511:
3485:
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3321:
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3023:
2974:
2922:
2883:
2848:
2579:
2530:
2426:
2385:
2336:
2304:
Tygacil . Philadelphia, PA: Wyeth Pharmaceuticals; 2005. Updated July 2010.
2263:
2230:
Susceptibility of Thai Pythium insidiosum Isolates to Antibacterial Agents"
2169:
2026:
1980:
1940:
1897:
1714:
1666:
1658:
1230:
1190:
1111:
1095:
805:
Tigecycline can treat complicated skin and structure infections caused by;
218:
3053:
2799:
2781:
2750:
2657:
2649:
2622:
2570:
2553:
2201:
2184:
2120:
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3901:
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3702:
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3536:
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3501:
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3175:
3158:
3005:
2830:
2245:
2223:
1420:
1400:
1321:
1091:
1087:
1049:
978:
Tigecycline is given intravenously and has activity against a variety of
125:
2742:
2614:
1816:
1770:
1741:
427:
3951:
3911:
3906:
3855:
3835:
3820:
3795:
3750:
3745:
3679:
3650:
3630:
3450:
3445:
3436:
3431:
3416:
3411:
3359:
3311:
3225:
2949:"Tigecycline: in-vitro performance as a predictor of clinical efficacy"
2350:
Muralidharan G, Micalizzi M, Speth J, Raible D, Troy S (January 2005).
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627:
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Zimmerman JJ, Raible DG, Harper DM, Matschke K, Speth JL (July 2008).
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values reported at 2 μg/mL) and multi-drug resistant strains of
991:
393:
334:
328:
111:
3865:
3335:
3306:
1556:"Tygacil- tigecycline injection, powder, lyophilized, for solution"
1300:
999:
487:
418:
153:
2813:
Petersen PJ, Jacobus NV, Weiss WJ, Sum PE, Testa RT (April 1999).
1296:
Tigecycline has been found to interact with medications, such as:
650:
3850:
3156:
2554:"Evaluation of a potential tigecycline-warfarin drug interaction"
2313:
2349:
1174:
Tigecycline generally has poor activity against most strains of
3947:
2133:
518:
338:
81:
30:
2551:
1114:. It also shows good activity against the causative agent of
641:
498:
2681:"The evolving response to antibiotic resistance (1945–2018)"
1810:(6th revision ed.). Geneva: World Health Organization.
1259:, with particular relevance to patients also diagnosed with
543:
1958:
1464:
TIGILITE (marketed in INDIA, Scutonix Lifesciences, Bombay)
1255:
More so, there are clinical reports of tigecycline-induced
1229:
As a tetracycline derivative, tigecycline exhibits similar
478:
72:
63:
57:
3087:
2004:
1221: have been found to cause resistance to tigecycline.
3607:
3258:
3039:
1802:
1755:
1727:
60:
2635:
1745:. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.
1356:. It exhibits bacteriostatic activity by binding to the
2812:
1918:
785:
World Health Organization's List of Essential Medicines
1808:
Critically important antimicrobials for human medicine
4046:
2987:
2896:
2039:
84:
75:
69:
51:
1550:
1360:
of bacteria and thereby blocking the interaction of
1014:
bacteria and anaerobes – including activity against
78:
54:
2899:"Tigecycline: A Novel Broad-Spectrum Antimicrobial"
2764:Goldstein FW, Kitzis MD, Acar JF (September 1994).
2763:
1548:
1546:
1544:
1542:
1540:
1538:
1536:
1534:
1532:
1530:
66:
2508:
1475:
2942:
2940:
2727:
2600:
2098:
4070:
2897:Slover CM, Rodvold KA, Danziger LH (June 2007).
1855:"TYGACIL U.S. Physician Prescribing Information"
1527:
1324:was a commonly used tetracycline synthesized in
406:
2471:
2469:
2438:
2436:
2182:
381:
2937:
1579:
1577:
996:complicated skin and skin structure infections
3210:
2398:
2317:International Journal of Antimicrobial Agents
1954:
1952:
1950:
1921:International Journal of Antimicrobial Agents
2890:
2864:Bioorganic & Medicinal Chemistry Letters
2466:
2433:
2392:
1912:
1640:
1638:
1636:
1634:
1483:"Tigecycline (Tygacil) Use During Pregnancy"
1201:Bacterial resistance towards tigecycline in
157:
2946:
2861:
1849:
1847:
1845:
1843:
1841:
1839:
1837:
1574:
1288:FDA updated the black box warning in 2013.
1181:
3678:
3217:
3203:
3083:
3081:
3079:
2183:Arora R, Jain S, Rahimi H (1 April 2018).
1947:
1875:
1695:American Journal of Health-System Pharmacy
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1686:
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580:
557:
446:
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3163:The Journal of Antimicrobial Chemotherapy
3035:
3033:
3013:
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2200:
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466:
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2504:
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1834:
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2511:Expert Review of Anti-Infective Therapy
1878:The Journal of Dermatological Treatment
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426:
130:
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2638:Clinical Pharmacology and Therapeutics
2399:Hemphill MT, Jones KR (January 2016).
1721:
1513:Therapeutic Goods Administration (TGA)
1427:
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1213:AcrAB. Some bacterial species such as
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571:
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2994:Antimicrobial Agents and Chemotherapy
2819:Antimicrobial Agents and Chemotherapy
2770:Antimicrobial Agents and Chemotherapy
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2356:Antimicrobial Agents and Chemotherapy
2234:Antimicrobial Agents and Chemotherapy
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1998:
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1735:. Geneva: World Health Organization.
1006:. Tigecycline is active against many
1002:and cilastatian to treat complicated
526:
506:
262:
148:
116:
1458:Tigeplug (marketed by Biocon, India)
1291:
1278:
1062:"Tigecycline is also active against
795:
222:
2953:Clinical Microbiology and Infection
1792:. WHO technical report series;1021.
1411:Tigecycline is metabolized through
1406:
486:
397:
13:
1995:
1415:into glucuronide conjugates and a
14:
4105:
2329:10.1016/j.ijantimicag.2016.04.017
1933:10.1016/j.ijantimicag.2015.03.012
1594:(in Aragonese). 17 September 2018
1387:derivative within a class called
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2947:Hawkey P, Finch R (April 2007).
2603:The Journal of Organic Chemistry
611:
605:
47:
29:
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3125:
3091:Drug Metabolism and Disposition
2981:
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2757:
2721:
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2629:
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2545:
2343:
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2270:
2217:
2176:
2127:
2092:
2033:
1869:
1796:
1224:
790:
698:Key:FPZLLRFZJZRHSY-HJYUBDRYSA-N
364:--2-(tert-butylamino) acetamide
3718:transpeptidation/translocation
2731:Journal of Medicinal Chemistry
1749:
1606:
1501:
1446:
1242:
1162:(methicillin-resistant): 0.03
769:organisms, including those of
617:
599:
1:
2903:The Annals of Pharmacotherapy
2876:10.1016/S0960-894X(99)00216-4
2679:Podolsky SH (December 2018).
2368:10.1128/aac.49.1.220-229.2005
1961:Expert Opinion on Drug Safety
1468:
1047:. It has no activity against
2523:10.1586/14787210.2014.894882
2483:Food and Drug Administration
2450:Food and Drug Administration
1973:10.1517/14740338.2015.997206
1024:Stenotrophomonas maltophilia
923:Bacteroides thetaiotaomicron
778:Food and Drug Administration
723:, sold under the brand name
7:
1432:
1354:protein synthesis inhibitor
731:medication for a number of
10:
4110:
2405:Journal of Cystic Fibrosis
2019:10.1016/j.phrs.2012.10.006
1316:
1004:intra-abdominal infections
589:Chemical and physical data
4094:Drugs developed by Pfizer
4084:Glycylcycline antibiotics
4007:
3962:Quinupristin/dalfopristin
3920:
3892:
3864:
3726:
3715:
3669:
3615:
3606:
3580:
3494:
3479:
3459:
3398:
3281:
3266:
3257:
3230:inhibit protein synthesis
2698:10.1057/s41599-018-0181-x
2418:10.1016/j.jcf.2015.07.008
2152:10.1016/j.ccr.2011.10.015
2113:10.3109/10715769709097783
1890:10.1080/09546630510011810
1804:World Health Organization
1757:World Health Organization
1729:World Health Organization
1590:European Medicines Agency
1383:It is a third-generation
1350:broad-spectrum antibiotic
894:, vancomycin-susceptible
811:, vancomycin-susceptible
706:
681:
661:
639:
626:
593:
588:
569:
537:
517:
497:
477:
457:
437:
417:
392:
372:
349:
344:
327:
314:
304:
294:
286:
239:
234:
209:
194:
168:
138:
124:
106:
96:
42:
37:
28:
4089:Drugs developed by Wyeth
3481:Tetracycline antibiotics
2067:10.1073/pnas.93.24.14014
2007:Pharmacological Research
1182:Liver or kidney problems
1064:Clostridioides difficile
955:Streptococcus pneumoniae
828:Streptococcus agalactiae
783:It was removed from the
2685:Palgrave Communications
2189:STEM Fellowship Journal
1106:activity against acute
1044:Acinetobacter baumannii
939:Clostridium perfringens
911:Streptococcus anginosus
834:Streptococcus anginosus
752:Acinetobacter baumannii
729:tetracycline antibiotic
3103:10.1124/dmd.107.015735
1659:10.1592/phco.26.8.1099
1618:European Patent Office
1266:Tigecycline showed an
1029:Haemophilus influenzae
1016:methicillin-resistant
971:Legionella pneumophila
964:that does not produce
961:Haemophilus influenzae
902:methicillin-resistant
840:Streptococcus pyogenes
819:methicillin-resistant
3054:10.1515/hsz-2013-0292
2782:10.1128/AAC.38.9.2218
2650:10.1002/cpt1973145852
2571:10.1592/phco.28.7.895
2202:10.17975/sfj-2018-002
2101:Free Radical Research
1358:30S ribosomal subunit
1197:Resistance mechanisms
1160:Staphylococcus aureus
1146:Klebsiella pneumoniae
1082:Non-Antibacterial use
1073:Clostridium difficile
1034:Neisseria gonorrhoeae
1018:Staphylococcus aureus
998:, and to intravenous
928:Bacteroides uniformis
904:Staphylococcus aureus
897:Enterococcus faecalis
891:Klebsiella pneumoniae
852:Klebsiella pneumoniae
821:Staphylococcus aureus
814:Enterococcus faecalis
771:multi-drug resistance
746:Staphylococcus aureus
3671:Peptidyl transferase
3042:Biological Chemistry
3006:10.1128/AAC.01499-05
2831:10.1128/AAC.43.4.738
2246:10.1128/AAC.02099-19
1326:Lederle Laboratories
1250:pregnancy category D
1211:RND type efflux pump
933:Bacteroides vulgatus
917:Bacteroides fragilis
873:Enterobacter cloacae
867:Citrobacter freundii
858:Bacteroides fragilis
846:Enterobacter cloacae
776:It was given a U.S.
741:antibiotic resistant
733:bacterial infections
3300:Dihydrostreptomycin
2743:10.1021/jm00027a023
2615:10.1021/jo00804a025
2487:. 27 September 2013
2058:1996PNAS...9314014A
2052:(24): 14014–14019.
1428:Society and culture
1344:Mechanism of action
1307:Oral contraceptives
1122:Susceptibility data
1094:and suppression of
258:(Prescription only)
25:
4034:Never to phase III
3176:10.1093/jac/dkf196
2454:. 1 September 2010
1707:10.2146/ajhp050487
1257:acute pancreatitis
1203:Enterobacteriaceae
945:Peptostreptococcus
885:Klebsiella oxytoca
21:
4044:
4043:
4003:
4002:
3999:
3998:
3711:
3710:
3602:
3601:
3598:
3597:
3507:Chlortetracycline
3475:
3474:
2915:10.1345/aph.1H543
2870:(10): 1459–1462.
1701:(13): 1235–1243.
1348:Tigecycline is a
1292:Drug interactions
1285:black box warning
1283:The FDA issued a
1279:Black box warning
1273:black box warning
796:Antibacterial use
743:bacteria such as
718:
717:
652:Interactive image
539:CompTox Dashboard
278:
266:
253:
184:
151:
16:Chemical compound
4101:
4061:
4060:
4059:
4052:
3724:
3723:
3676:
3675:
3613:
3612:
3562:Rolitetracycline
3492:
3491:
3279:
3278:
3264:
3263:
3219:
3212:
3205:
3196:
3195:
3189:
3188:
3178:
3154:
3148:
3147:
3145:
3143:
3137:Medicines.org.uk
3129:
3123:
3122:
3097:(9): 1543–1553.
3085:
3074:
3073:
3037:
3028:
3027:
3017:
3000:(6): 2156–2166.
2985:
2979:
2978:
2968:
2944:
2935:
2934:
2894:
2888:
2887:
2859:
2853:
2852:
2842:
2810:
2804:
2803:
2793:
2776:(9): 2218–2220.
2761:
2755:
2754:
2725:
2719:
2718:
2700:
2676:
2670:
2669:
2633:
2627:
2626:
2598:
2592:
2591:
2573:
2549:
2543:
2542:
2506:
2497:
2496:
2494:
2492:
2473:
2464:
2463:
2461:
2459:
2440:
2431:
2430:
2420:
2396:
2390:
2389:
2379:
2347:
2341:
2340:
2311:
2305:
2302:
2296:
2295:
2293:
2291:
2282:
2274:
2268:
2267:
2257:
2221:
2215:
2214:
2204:
2180:
2174:
2173:
2163:
2131:
2125:
2124:
2096:
2090:
2089:
2079:
2069:
2037:
2031:
2030:
2002:
1993:
1992:
1956:
1945:
1944:
1916:
1910:
1909:
1873:
1867:
1866:
1864:
1862:
1851:
1832:
1831:
1819:
1800:
1794:
1793:
1773:
1753:
1747:
1746:
1744:
1725:
1719:
1718:
1690:
1679:
1678:
1653:(8): 1099–1110.
1642:
1629:
1628:
1626:
1624:
1610:
1604:
1603:
1601:
1599:
1581:
1572:
1571:
1569:
1567:
1552:
1525:
1524:
1522:
1520:
1505:
1499:
1498:
1496:
1494:
1479:
1407:Pharmacokinetics
1132:Escherichia coli
1108:myeloid leukemia
879:Escherichia coli
808:Escherichia coli
714:
713:
654:
634:
619:
613:
607:
601:
584:
573:
562:
561:
547:
545:
530:
510:
490:
470:
450:
430:
410:
400:
399:
385:
319:
276:
273:
264:
261:
251:
248:
226:
182:
179:
161:
150:
147:
134:
120:
91:
90:
87:
86:
83:
80:
77:
74:
71:
68:
65:
62:
59:
56:
53:
33:
26:
24:
20:
4109:
4108:
4104:
4103:
4102:
4100:
4099:
4098:
4069:
4068:
4067:
4057:
4055:
4047:
4045:
4040:
4039:
4024:Clinical trials
3995:
3981:Streptogramin B
3976:Streptogramin A
3916:
3888:
3860:
3707:
3688:Chloramphenicol
3665:
3619:
3594:
3576:
3557:Penimepicycline
3552:Oxytetracycline
3483:
3471:
3455:
3394:
3270:
3268:Aminoglycosides
3253:
3223:
3193:
3192:
3155:
3151:
3141:
3139:
3131:
3130:
3126:
3086:
3077:
3038:
3031:
2986:
2982:
2945:
2938:
2895:
2891:
2860:
2856:
2811:
2807:
2762:
2758:
2726:
2722:
2677:
2673:
2634:
2630:
2599:
2595:
2558:Pharmacotherapy
2550:
2546:
2507:
2500:
2490:
2488:
2475:
2474:
2467:
2457:
2455:
2442:
2441:
2434:
2397:
2393:
2348:
2344:
2312:
2308:
2303:
2299:
2289:
2287:
2280:
2276:
2275:
2271:
2222:
2218:
2181:
2177:
2132:
2128:
2097:
2093:
2038:
2034:
2003:
1996:
1957:
1948:
1917:
1913:
1874:
1870:
1860:
1858:
1853:
1852:
1835:
1828:
1801:
1797:
1782:
1754:
1750:
1726:
1722:
1691:
1682:
1647:Pharmacotherapy
1643:
1632:
1622:
1620:
1612:
1611:
1607:
1597:
1595:
1583:
1582:
1575:
1565:
1563:
1554:
1553:
1528:
1518:
1516:
1507:
1506:
1502:
1492:
1490:
1481:
1480:
1476:
1471:
1449:
1435:
1430:
1419:-acetyl-9-amino
1413:glucuronidation
1409:
1352:that acts as a
1346:
1319:
1294:
1281:
1261:cystic fibrosis
1245:
1227:
1199:
1184:
1124:
1084:
798:
793:
709:
707:
702:
699:
694:
689:
688:
677:
674:
669:
668:
657:
632:
622:
616:
610:
604:
565:
541:
533:
513:
493:
473:
453:
433:
413:
396:
388:
368:
365:
357:
356:
317:
310:Not metabolized
296:Protein binding
288:Pharmacokinetic
282:
230:
197:
190:
171:
164:
50:
46:
17:
12:
11:
5:
4107:
4097:
4096:
4091:
4086:
4081:
4066:
4065:
4042:
4041:
4038:
4037:
4036:
4035:
4032:
4021:
4015:
4009:
4008:
4005:
4004:
4001:
4000:
3997:
3996:
3994:
3993:
3983:
3978:
3973:
3959:
3945:
3926:
3924:
3922:Streptogramins
3918:
3917:
3915:
3914:
3909:
3904:
3898:
3896:
3890:
3889:
3887:
3886:
3881:
3876:
3870:
3868:
3862:
3861:
3859:
3858:
3853:
3848:
3843:
3841:Troleandomycin
3838:
3833:
3828:
3823:
3818:
3813:
3808:
3803:
3798:
3793:
3788:
3783:
3778:
3773:
3771:Flurithromycin
3768:
3763:
3758:
3756:Clarithromycin
3753:
3748:
3743:
3738:
3732:
3730:
3721:
3713:
3712:
3709:
3708:
3706:
3705:
3700:
3695:
3690:
3684:
3682:
3673:
3667:
3666:
3664:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3627:
3625:
3610:
3604:
3603:
3600:
3599:
3596:
3595:
3593:
3592:
3586:
3584:
3582:Glycylcyclines
3578:
3577:
3575:
3574:
3569:
3564:
3559:
3554:
3549:
3544:
3539:
3534:
3529:
3524:
3519:
3517:Demeclocycline
3514:
3509:
3504:
3498:
3496:
3489:
3477:
3476:
3473:
3472:
3470:
3469:
3463:
3461:
3457:
3456:
3454:
3453:
3448:
3442:
3441:
3440:
3439:
3434:
3429:
3424:
3419:
3408:
3406:
3402:Micromonospora
3396:
3395:
3393:
3392:
3390:Nourseothricin
3387:
3382:
3377:
3372:
3367:
3356:
3355:
3354:
3353:
3348:
3343:
3338:
3327:
3326:
3325:
3324:
3319:
3314:
3303:
3302:
3297:
3291:
3289:
3276:
3261:
3255:
3254:
3226:Antibacterials
3222:
3221:
3214:
3207:
3199:
3191:
3190:
3169:(5): 758–759.
3149:
3124:
3075:
3048:(5): 559–575.
3029:
2980:
2959:(4): 354–362.
2936:
2889:
2854:
2825:(4): 738–744.
2805:
2756:
2737:(1): 184–188.
2720:
2671:
2644:(5): 852–861.
2628:
2609:(5): 723–725.
2593:
2564:(7): 895–905.
2544:
2517:(4): 397–400.
2498:
2465:
2432:
2391:
2362:(1): 220–229.
2342:
2306:
2297:
2269:
2216:
2175:
2146:(5): 674–688.
2126:
2091:
2032:
1994:
1967:(2): 335–342.
1946:
1911:
1884:(4): 207–212.
1868:
1833:
1826:
1795:
1780:
1748:
1720:
1680:
1630:
1605:
1585:"Tygacil EPAR"
1573:
1562:. 20 July 2020
1526:
1515:. 21 June 2022
1500:
1473:
1472:
1470:
1467:
1466:
1465:
1462:
1459:
1456:
1453:
1448:
1445:
1440:United Kingdom
1434:
1431:
1429:
1426:
1408:
1405:
1391:which carry a
1389:glycylcyclines
1373:L. pneumophila
1362:aminoacyl-tRNA
1345:
1342:
1338:glycylcyclines
1334:glycylcyclines
1318:
1315:
1311:
1310:
1304:
1293:
1290:
1280:
1277:
1244:
1241:
1226:
1223:
1198:
1195:
1183:
1180:
1172:
1171:
1157:
1143:
1123:
1120:
1083:
1080:
1066:strains. Most
976:
975:
966:Beta-lactamase
950:
862:
797:
794:
792:
789:
716:
715:
704:
703:
701:
700:
697:
695:
692:
684:
683:
682:
679:
678:
676:
675:
672:
664:
663:
662:
659:
658:
656:
655:
647:
645:
637:
636:
630:
624:
623:
620:
614:
608:
602:
597:
591:
590:
586:
585:
575:
567:
566:
564:
563:
550:
548:
535:
534:
532:
531:
523:
521:
515:
514:
512:
511:
503:
501:
495:
494:
492:
491:
483:
481:
475:
474:
472:
471:
463:
461:
455:
454:
452:
451:
443:
441:
435:
434:
432:
431:
423:
421:
415:
414:
412:
411:
403:
401:
390:
389:
387:
386:
378:
376:
370:
369:
367:
366:
360:
352:
351:
350:
347:
346:
342:
341:
331:
325:
324:
321:
312:
311:
308:
302:
301:
298:
292:
291:
284:
283:
281:
280:
271:
259:
245:
243:
237:
236:
232:
231:
229:
228:
215:
213:
207:
206:
200:
198:administration
192:
191:
189:
188:
186:
176:
174:
166:
165:
163:
162:
144:
142:
136:
135:
128:
122:
121:
114:
104:
103:
100:
94:
93:
44:
40:
39:
35:
34:
15:
9:
6:
4:
3:
2:
4106:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4076:
4074:
4064:
4054:
4053:
4050:
4033:
4031:
4028:
4027:
4025:
4022:
4019:
4016:
4014:
4011:
4010:
4006:
3991:
3987:
3986:Virginiamycin
3984:
3982:
3979:
3977:
3974:
3971:
3967:
3963:
3960:
3957:
3953:
3949:
3946:
3943:
3939:
3935:
3931:
3930:Pristinamycin
3928:
3927:
3925:
3923:
3919:
3913:
3910:
3908:
3905:
3903:
3900:
3899:
3897:
3895:
3891:
3885:
3884:Solithromycin
3882:
3880:
3877:
3875:
3874:Telithromycin
3872:
3871:
3869:
3867:
3863:
3857:
3854:
3852:
3849:
3847:
3846:Tulathromycin
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3826:Telithromycin
3824:
3822:
3819:
3817:
3816:Solithromycin
3814:
3812:
3811:Roxithromycin
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3776:Gamithromycin
3774:
3772:
3769:
3767:
3764:
3762:
3761:Dirithromycin
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3733:
3731:
3729:
3725:
3722:
3719:
3714:
3704:
3701:
3699:
3698:Thiamphenicol
3696:
3694:
3693:Azidamfenicol
3691:
3689:
3686:
3685:
3683:
3681:
3677:
3674:
3672:
3668:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3628:
3626:
3623:
3618:
3617:Oxazolidinone
3614:
3611:
3609:
3605:
3591:
3588:
3587:
3585:
3583:
3579:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3518:
3515:
3513:
3510:
3508:
3505:
3503:
3500:
3499:
3497:
3495:Tetracyclines
3493:
3490:
3487:
3482:
3478:
3468:
3465:
3464:
3462:
3458:
3452:
3449:
3447:
3444:
3443:
3438:
3435:
3433:
3430:
3428:
3425:
3423:
3420:
3418:
3415:
3414:
3413:
3410:
3409:
3407:
3404:
3403:
3397:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3370:Spectinomycin
3368:
3365:
3361:
3358:
3357:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3333:
3332:
3329:
3328:
3323:
3320:
3318:
3315:
3313:
3310:
3309:
3308:
3305:
3304:
3301:
3298:
3296:
3293:
3292:
3290:
3287:
3286:
3280:
3277:
3274:
3269:
3265:
3262:
3260:
3256:
3251:
3247:
3243:
3239:
3235:
3231:
3227:
3220:
3215:
3213:
3208:
3206:
3201:
3200:
3197:
3186:
3182:
3177:
3172:
3168:
3164:
3160:
3153:
3138:
3134:
3128:
3120:
3116:
3112:
3108:
3104:
3100:
3096:
3092:
3084:
3082:
3080:
3071:
3067:
3063:
3059:
3055:
3051:
3047:
3043:
3036:
3034:
3025:
3021:
3016:
3011:
3007:
3003:
2999:
2995:
2991:
2984:
2976:
2972:
2967:
2962:
2958:
2954:
2950:
2943:
2941:
2932:
2928:
2924:
2920:
2916:
2912:
2909:(6): 965–72.
2908:
2904:
2900:
2893:
2885:
2881:
2877:
2873:
2869:
2865:
2858:
2850:
2846:
2841:
2836:
2832:
2828:
2824:
2820:
2816:
2809:
2801:
2797:
2792:
2787:
2783:
2779:
2775:
2771:
2767:
2760:
2752:
2748:
2744:
2740:
2736:
2732:
2724:
2716:
2712:
2708:
2704:
2699:
2694:
2690:
2686:
2682:
2675:
2667:
2663:
2659:
2655:
2651:
2647:
2643:
2639:
2632:
2624:
2620:
2616:
2612:
2608:
2604:
2597:
2589:
2585:
2581:
2577:
2572:
2567:
2563:
2559:
2555:
2548:
2540:
2536:
2532:
2528:
2524:
2520:
2516:
2512:
2505:
2503:
2486:
2484:
2478:
2472:
2470:
2453:
2451:
2445:
2439:
2437:
2428:
2424:
2419:
2414:
2410:
2406:
2402:
2395:
2387:
2383:
2378:
2373:
2369:
2365:
2361:
2357:
2353:
2346:
2338:
2334:
2330:
2326:
2322:
2318:
2310:
2301:
2286:
2279:
2273:
2265:
2261:
2256:
2251:
2247:
2243:
2239:
2235:
2231:
2229:
2220:
2212:
2208:
2203:
2198:
2194:
2190:
2186:
2179:
2171:
2167:
2162:
2157:
2153:
2149:
2145:
2141:
2137:
2130:
2122:
2118:
2114:
2110:
2106:
2102:
2095:
2087:
2083:
2078:
2073:
2068:
2063:
2059:
2055:
2051:
2047:
2043:
2036:
2028:
2024:
2020:
2016:
2012:
2008:
2001:
1999:
1990:
1986:
1982:
1978:
1974:
1970:
1966:
1962:
1955:
1953:
1951:
1942:
1938:
1934:
1930:
1926:
1922:
1915:
1907:
1903:
1899:
1895:
1891:
1887:
1883:
1879:
1872:
1856:
1850:
1848:
1846:
1844:
1842:
1840:
1838:
1829:
1827:9789241515528
1823:
1818:
1813:
1809:
1805:
1799:
1791:
1787:
1783:
1781:9789241210300
1777:
1772:
1767:
1763:
1758:
1752:
1743:
1738:
1734:
1730:
1724:
1716:
1712:
1708:
1704:
1700:
1696:
1689:
1687:
1685:
1676:
1672:
1668:
1664:
1660:
1656:
1652:
1648:
1641:
1639:
1637:
1635:
1619:
1615:
1609:
1593:
1591:
1586:
1580:
1578:
1561:
1557:
1551:
1549:
1547:
1545:
1543:
1541:
1539:
1537:
1535:
1533:
1531:
1514:
1510:
1504:
1489:. 6 July 2020
1488:
1484:
1478:
1474:
1463:
1460:
1457:
1454:
1451:
1450:
1444:
1441:
1425:
1422:
1418:
1414:
1404:
1402:
1398:
1394:
1390:
1386:
1381:
1377:
1376:
1374:
1369:
1368:
1367:S. pneumoniae
1363:
1359:
1355:
1351:
1341:
1339:
1335:
1330:
1327:
1323:
1314:
1308:
1305:
1302:
1299:
1298:
1297:
1289:
1286:
1276:
1274:
1269:
1264:
1262:
1258:
1253:
1251:
1240:
1237:
1234:
1232:
1222:
1220:
1216:
1212:
1208:
1204:
1194:
1192:
1187:
1179:
1177:
1169:
1165:
1161:
1158:
1155:
1151:
1147:
1144:
1141:
1137:
1133:
1130:
1129:
1128:
1119:
1117:
1113:
1109:
1105:
1101:
1097:
1093:
1089:
1079:
1076:
1074:
1069:
1065:
1060:
1058:
1057:
1052:
1051:
1046:
1045:
1040:
1036:
1035:
1030:
1026:
1025:
1020:
1019:
1013:
1012:Gram-negative
1009:
1008:Gram-positive
1005:
1001:
997:
993:
989:
985:
984:Gram-negative
981:
980:Gram-positive
973:
972:
967:
963:
962:
957:
956:
951:
948:
946:
941:
940:
935:
934:
929:
925:
924:
919:
918:
913:
912:
907:
905:
899:
898:
893:
892:
887:
886:
881:
880:
875:
874:
869:
868:
863:
860:
859:
854:
853:
848:
847:
842:
841:
836:
835:
830:
829:
824:
822:
816:
815:
810:
809:
804:
803:
802:
788:
786:
781:
779:
774:
772:
768:
767:Gram-negative
764:
763:Gram-positive
760:
759:
754:
753:
748:
747:
742:
738:
737:glycylcycline
734:
730:
726:
722:
712:
705:
696:
691:
690:
687:
680:
671:
670:
667:
660:
653:
649:
648:
646:
643:
638:
631:
629:
625:
598:
596:
592:
587:
583:
579:
576:
574:
572:ECHA InfoCard
568:
560:
556:
555:DTXSID2048581
552:
551:
549:
540:
536:
529:
525:
524:
522:
520:
516:
509:
505:
504:
502:
500:
496:
489:
485:
484:
482:
480:
476:
469:
465:
464:
462:
460:
456:
449:
445:
444:
442:
440:
436:
429:
425:
424:
422:
420:
416:
409:
405:
404:
402:
395:
391:
384:
380:
379:
377:
375:
371:
363:
359:
358:
355:
348:
343:
340:
336:
332:
330:
326:
322:
320:
313:
309:
307:
303:
299:
297:
293:
289:
285:
279: Rx-only
272:
270:
260:
257:
247:
246:
244:
242:
238:
233:
225:
220:
217:
216:
214:
212:
208:
204:
201:
199:
193:
187:
178:
177:
175:
173:
167:
160:
155:
146:
145:
143:
141:
137:
133:
129:
127:
123:
119:
115:
113:
109:
105:
101:
99:
95:
89:
45:
43:Pronunciation
41:
38:Clinical data
36:
32:
27:
19:
4079:Carboxamides
3970:Quinupristin
3966:Dalfopristin
3894:Lincosamides
3831:Tildipirosin
3801:Oleandomycin
3766:Erythromycin
3736:Azithromycin
3589:
3572:Tetracycline
3547:Omadacycline
3532:Meclocycline
3522:Eravacycline
3512:Clomocycline
3427:Micronomicin
3400:
3375:Hygromycin B
3364:+loteprednol
3322:Ribostamycin
3295:Streptomycin
3285:Streptomyces
3283:
3166:
3162:
3152:
3140:. Retrieved
3136:
3127:
3094:
3090:
3045:
3041:
2997:
2993:
2983:
2956:
2952:
2906:
2902:
2892:
2867:
2863:
2857:
2822:
2818:
2808:
2773:
2769:
2759:
2734:
2730:
2723:
2688:
2684:
2674:
2641:
2637:
2631:
2606:
2602:
2596:
2561:
2557:
2547:
2514:
2510:
2491:26 September
2489:. Retrieved
2480:
2456:. Retrieved
2447:
2411:(1): e9-11.
2408:
2404:
2394:
2359:
2355:
2345:
2323:(1): 11–18.
2320:
2316:
2309:
2300:
2288:. Retrieved
2284:
2272:
2237:
2233:
2227:
2219:
2192:
2188:
2178:
2143:
2139:
2129:
2107:(1): 49–56.
2104:
2100:
2094:
2049:
2045:
2035:
2013:(1): 18–30.
2010:
2006:
1964:
1960:
1924:
1920:
1914:
1881:
1877:
1871:
1859:. Retrieved
1817:10665/312266
1807:
1798:
1771:10665/330668
1760:
1751:
1742:10665/325773
1732:
1723:
1698:
1694:
1650:
1646:
1623:29 September
1621:. Retrieved
1617:
1608:
1598:26 September
1596:. Retrieved
1588:
1566:26 September
1564:. Retrieved
1559:
1517:. Retrieved
1512:
1503:
1493:26 September
1491:. Retrieved
1486:
1477:
1436:
1416:
1410:
1396:
1392:
1385:tetracycline
1382:
1378:
1371:
1365:
1347:
1331:
1320:
1312:
1295:
1282:
1275:by the FDA.
1267:
1265:
1254:
1246:
1238:
1235:
1231:side effects
1228:
1225:Side effects
1218:
1214:
1206:
1200:
1191:hemodialysis
1188:
1185:
1175:
1173:
1167:
1163:
1159:
1153:
1149:
1145:
1139:
1135:
1131:
1125:
1112:glioblastoma
1103:
1099:
1096:angiogenesis
1085:
1077:
1072:
1068:C. difficile
1067:
1063:
1061:
1054:
1048:
1042:
1032:
1028:
1022:
1017:
977:
969:
959:
953:
943:
937:
931:
927:
921:
915:
909:
903:
895:
889:
883:
877:
871:
865:
856:
850:
844:
838:
832:
826:
820:
812:
806:
799:
791:Medical uses
782:
775:
756:
750:
744:
724:
720:
719:
708:
528:ChEMBL376140
508:CHEBI:149836
361:
316:Elimination
241:Legal status
235:Legal status
140:License data
18:
4020:from market
3956:Linopristin
3902:Clindamycin
3879:Cethromycin
3806:Rokitamycin
3791:Midecamycin
3786:Kitasamycin
3703:Florfenicol
3680:Amphenicols
3624:inhibitors)
3590:Tigecycline
3567:Sarecycline
3542:Minocycline
3537:Metacycline
3527:Lymecycline
3502:Doxycycline
3346:Bekanamycin
3317:Paromomycin
3275:inhibitors)
2195:(1): 5–11.
2140:Cancer Cell
1927:(1): 8–12.
1614:"EP2181330"
1447:Other names
1421:minocycline
1401:minocycline
1322:Minocycline
1243:Precautions
1215:Pseudomonas
1176:Pseudomonas
1092:proteolysis
1088:Minocycline
1075:infection.
1050:Pseudomonas
721:Tigecycline
635: g·mol
578:100.211.439
383:220620-09-7
345:Identifiers
203:Intravenous
159:Tigecycline
126:MedlinePlus
98:Trade names
23:Tigecycline
4073:Categories
3952:Flopristin
3912:Pirlimycin
3907:Lincomycin
3856:Tylvalosin
3836:Tilmicosin
3821:Spiramycin
3796:Miocamycin
3751:Carrimycin
3746:Carbomycin
3728:Macrolides
3651:Ranbezolid
3631:Eperezolid
3622:initiation
3451:Astromicin
3446:Verdamicin
3437:Isepamicin
3432:Plazomicin
3417:Netilmicin
3412:Gentamicin
3360:Tobramycin
3312:Framycetin
3273:initiation
2691:(1): 124.
2285:Toku-e.com
1861:31 October
1469:References
1152:g/mL — 16
1010:bacteria,
988:vancomycin
735:. It is a
640:3D model (
628:Molar mass
468:70JE2N95KR
439:ChemSpider
374:CAS Number
354:IUPAC name
323:42.4 hours
306:Metabolism
4030:Phase III
4018:Withdrawn
3866:Ketolides
3781:Josamycin
3741:Boromycin
3661:Tedizolid
3656:Sutezolid
3646:Radezolid
3641:Posizolid
3636:Linezolid
3467:Butirosin
3422:Sisomicin
3385:Apramycin
3380:Totomycin
3351:Dibekacin
3341:Arbekacin
3331:Kanamycin
2707:2055-1045
2211:2369-0399
1790:0512-3054
1762:Children)
1487:Drugs.com
1268:increased
1205:(such as
1166:g/mL — 2
1138:g/mL — 4
1116:pythiosis
1021:(MRSA),
994:to treat
992:aztreonam
335:Bile duct
329:Excretion
318:half-life
196:Routes of
170:Pregnancy
118:Monograph
112:Drugs.com
4063:Medicine
3488:binding)
3399:-micin (
3336:Amikacin
3307:Neomycin
3282:-mycin (
3185:12407139
3142:13 March
3111:17537869
3070:12668198
3062:24497223
3024:16723578
2975:17359318
2923:17519296
2884:10360756
2849:10103174
2715:53086078
2666:30279473
2580:18576904
2539:36614422
2531:24597542
2458:13 March
2427:26282838
2386:15616299
2337:27256586
2290:13 March
2264:32015039
2228:In Vitro
2170:22094260
2027:23085382
1989:43407481
1981:25539800
1941:25982915
1906:28869637
1898:16249141
1857:. Pfizer
1806:(2019).
1759:(2019).
1731:(2019).
1715:16790575
1675:29714610
1667:16863487
1560:DailyMed
1519:30 March
1433:Approval
1301:Warfarin
1207:E. coli)
1134:: 0.015
1100:in vitro
1053:spp. or
1000:imipenem
711:(verify)
448:10482314
419:DrugBank
211:ATC code
172:category
154:DailyMed
3851:Tylosin
3119:5070076
3015:1479133
2931:5686856
2800:7811053
2751:8289194
2658:4199710
2623:5545572
2588:3474652
2255:7179303
2161:3221282
2121:9018471
2086:8943052
2054:Bibcode
1455:Tygacil
1452:GAR-936
1317:History
1148:: 0.06
1104:in vivo
1056:Proteus
758:E. coli
727:, is a
725:Tygacil
633:585.658
595:Formula
428:DB00560
408:5282044
394:PubChem
227:)
221: (
219:J01AA12
185: D
156::
132:a614002
102:Tygacil
4049:Portal
4013:WHO-EM
3948:NXL103
3250:QJ01XQ
3183:
3117:
3109:
3068:
3060:
3022:
3012:
2973:
2929:
2921:
2882:
2847:
2837:
2798:
2791:284718
2788:
2749:
2713:
2705:
2664:
2656:
2621:
2586:
2578:
2537:
2529:
2425:
2384:
2377:538906
2374:
2335:
2262:
2252:
2209:
2168:
2158:
2119:
2084:
2074:
2025:
1987:
1979:
1939:
1904:
1896:
1824:
1788:
1778:
1713:
1673:
1665:
1037:(with
1031:, and
947:micros
942:, and
914:grp.,
906:(MRSA)
855:, and
837:grp.,
823:(MRSA)
755:, and
666:SMILES
519:ChEMBL
488:D01079
339:kidney
337:, 33%
300:71–89%
269:℞-only
267:
254:
152:
92:
3716:MLS (
3460:other
3228:that
3115:S2CID
3066:S2CID
2927:S2CID
2840:89200
2711:S2CID
2662:S2CID
2584:S2CID
2535:S2CID
2485:(FDA)
2481:U.S.
2452:(FDA)
2448:U.S.
2281:(PDF)
2240:(4).
2077:19486
1985:S2CID
1902:S2CID
1671:S2CID
1592:(EMA)
686:InChI
642:JSmol
499:ChEBI
3486:tRNA
3246:J01G
3242:J01F
3238:J01B
3234:J01A
3181:PMID
3144:2017
3107:PMID
3058:PMID
3020:PMID
2971:PMID
2919:PMID
2880:PMID
2845:PMID
2796:PMID
2747:PMID
2703:ISSN
2654:PMID
2619:PMID
2576:PMID
2527:PMID
2493:2020
2460:2017
2423:PMID
2382:PMID
2333:PMID
2292:2017
2260:PMID
2207:ISSN
2166:PMID
2117:PMID
2082:PMID
2023:PMID
1977:PMID
1937:PMID
1894:PMID
1863:2015
1822:ISBN
1786:ISSN
1776:ISBN
1711:PMID
1663:PMID
1625:2017
1600:2020
1568:2020
1521:2024
1495:2020
1370:and
1219:rpsJ
1170:g/mL
1156:g/mL
1142:g/mL
1102:and
990:and
982:and
968:and
765:and
479:KEGG
459:UNII
333:59%
290:data
205:(IV)
108:AHFS
3942:IIB
3938:IIA
3608:50S
3259:30S
3171:doi
3099:doi
3050:doi
3046:395
3010:PMC
3002:doi
2961:doi
2911:doi
2872:doi
2835:PMC
2827:doi
2786:PMC
2778:doi
2739:doi
2693:doi
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