94:). Frequency was estimated to be about 1 in 100,000 cancers; however, this proportion might be an under- or an overestimate. For one, not all cases of spontaneous regression can be apprehended, either because the case was not well documented or the physician was not willing to publish, or simply because the patient ceased to attend a clinic any more. On the other hand, for the past 100 years almost all cancer patients have received some form of treatment, and the influence of that treatment cannot always be excluded.
134:(growth of new blood vessels) are sometimes discussed as possible causes of spontaneous regression. But both mechanisms need appropriate biochemical triggers and cannot initiate on their own. Indeed, in many cancer cells apoptosis is defective, and angiogenesis is activated, both of these effects being caused by mutations in cancer cells; cancer exists because both mechanisms are malfunctioning.
69:
The spontaneous regression and remission from cancer was defined by
Everson and Cole in their 1966 book as "the partial or complete disappearance of a malignant tumour in the absence of all treatment, or in the presence of therapy which is considered inadequate to exert significant influence on
145:, suggesting a possible causal connection. If this coincidence in time would be a causal connection, it should as well precipitate as prophylactic effect, i.e. feverish infections should lower the risk to develop cancer later. This could be confirmed by collecting epidemiological studies.
123:
Challis and Stam, even more at a loss, concluded in 1989, "In summary, we are left to conclude that, although a great number of interesting and unusual cases continue to be published annually, there is still little conclusive data that explains the occurrence of spontaneous regression."
114:
it must be acknowledged that the factors or mechanisms responsible for spontaneous regression are obscure or unknown in the light of present knowledge. However, in some of the cases, available knowledge permits one to infer that hormonal influences probably were
97:
It is likely that the frequency of spontaneous regression in small tumors has been drastically underrated. In a carefully designed study on mammography it was found that 22% of all breast cancer cases underwent spontaneous regression.
78:
It has long been assumed that spontaneous regressions, let alone cures, from cancer are rare phenomena, and that some forms of cancer are more prone to unexpected courses (
41:, is an unexpected improvement or cure from a disease that usually progresses. These terms are commonly used for unexpected transient or final improvements in
554:
527:
Rohdenburg, G. L. (1 April 1918). "Fluctuations in the Growth Energy of
Malignant Tumors in Man, with Especial Reference to Spontaneous Recession".
50:
291:
Zahl, P. H.; Maehlen, J.; Welch, H. G. (2008). "The natural history of invasive breast cancers detected by screening mammography".
469:"Mistletoe lectin has a shiga toxin-like structure and should be combined with other Toll-like receptor ligands in cancer therapy"
17:
739:
644:
753:
711:
432:
Hobohm, U.; Stanford, J. L.; Grange, J. M. (2008). "Pathogen-associated molecular pattern in cancer immunotherapy".
786:
468:
608:
Cole, W. H. (1976). "Spontaneous regression of cancer and the importance of finding its cause".
169:
O'Regan
Brendan, Carlyle Hirschberg collected over 3,500 references from the medical literature
678:
548:
46:
180:
8:
663:
Spontaneous
Remission of Cancer: Theories from Healers, Physicians, and Cancer Survivors
496:
260:
235:
137:
There are several case reports of spontaneous regressions from cancer occurring after a
119:
In other cases, the protocols strongly suggest that an immune mechanism was responsible.
509:
409:
384:
273:
568:
Fauvet, J.; Roujeau, J.; Piet, R. (1964). "Spontaneous Cancer Cures and
Regressions".
791:
757:
735:
707:
640:
617:
577:
501:
449:
445:
414:
352:
308:
265:
513:
536:
491:
483:
441:
404:
396:
342:
300:
255:
247:
277:
703:
304:
106:
Everson and Cole offered as explanation for spontaneous regression from cancer:
487:
347:
330:
780:
173:
83:
771:
661:
581:
505:
453:
418:
400:
331:"The spontaneous regression of cancer. A review of cases from 1900 to 1987"
312:
269:
131:
356:
251:
621:
540:
183:
study, conducted interviews with 20 patients with spontaneous remissions
27:
Diminution or abatement of a disease over time, without formal treatment
142:
127:
91:
58:
666:(Thesis). Berkeley: UC Berkeley Electronic Theses and Dissertations.
749:
683:
87:
79:
54:
697:
73:
42:
466:
467:
Maletzki, C.; Linnebacher, M.; Savai, R.; Hobohm, U. (2013).
138:
61:
tumors; however, both terms are often used interchangeably.
163:
Everson and Cole described 176 cases between 1900 and 1960
154:
Rohdenburg (1918) summarized 185 spontaneous regressions
772:
Spontaneous remissions and an immunological explanation
639:. Sausalito, California: Institute of Noetic Sciences.
634:
431:
598:
Charles Thomas, Publ., Springfield Ill. 1966 (Book)
211:
209:
207:
166:Challis summarized 489 cases between 1900 and 1987
567:
553:: CS1 maint: DOI inactive as of September 2024 (
778:
637:Spontaneous Remission. An Annotated Bibliography
290:
45:. Spontaneous remissions concern cancers of the
676:
204:
157:Fauvet reported 202 cases between 1960 and 1964
754:The Body Can Beat Terminal Cancer — Sometimes.
635:O'Regan, Brendan; Hirschberg, Carlyle (1993).
74:Frequency of spontaneous regression in cancer
748:, American Scientist January–February 2009
698:Caryle Hirshberg; Marc Ian Barasch (1996).
328:
526:
495:
408:
346:
324:
322:
259:
229:
227:
225:
57:), while spontaneous regressions concern
219:Philadelphia, JB Saunder & Co (Book)
460:
14:
779:
659:
382:
319:
233:
222:
596:The spontaneous regression of cancer.
425:
746:Harnessing Infection to Fight Cancer
607:
329:Challis, G. B.; Stam, H. J. (1990).
610:National Cancer Institute Monograph
284:
24:
724:
677:Geoggrey Cowley (March 13, 1995).
25:
803:
765:
236:"Fever and cancer in perspective"
476:Cancer Immunology, Immunotherapy
446:10.1615/critrevimmunol.v28.i2.10
240:Cancer Immunology, Immunotherapy
217:Spontaneous Regression of Cancer
691:
670:
653:
628:
601:
588:
561:
176:, investigated about 1000 cases
529:The Journal of Cancer Research
520:
434:Critical Reviews in Immunology
376:
363:
160:Boyd reported 98 cases in 1966
110:In many of the collected cases
13:
1:
293:Archives of Internal Medicine
197:
64:
679:"Surviving Against All Odds"
305:10.1001/archinte.168.21.2311
130:(programmed cell death) and
7:
215:Everson T., Cole W. (1968)
10:
808:
660:Turner, Kelly Ann (2010).
369:Robert A. Weinberg (2007)
187:Surviving Against All Odds
148:
488:10.1007/s00262-013-1455-1
389:British Journal of Cancer
385:"Fever therapy revisited"
348:10.3109/02841869009090048
101:
191:a gamma interferon study
189:- re sole survivor in "
543:(inactive 2024-09-12).
401:10.1038/sj.bjc.6602386
121:
39:spontaneous regression
18:Spontaneous regression
570:La Revue du Praticien
371:The Biology of Cancer
252:10.1007/s002620100216
108:
70:neoplastic disease."
47:haematopoietic system
31:Spontaneous remission
541:10.1158/jcr.1918.193
181:qualitative research
787:Medical terminology
700:Remarkable Recovery
383:Hobohm, U. (2005).
234:Hobohm, U. (2001).
35:spontaneous healing
758:Discover Magazine
740:978-0-557-02885-6
646:978-0-943951-17-1
373:, Garland Science
16:(Redirected from
799:
761:, September 2007
718:
717:
695:
689:
688:
674:
668:
667:
657:
651:
650:
632:
626:
625:
605:
599:
592:
586:
585:
565:
559:
558:
552:
544:
524:
518:
517:
499:
473:
464:
458:
457:
429:
423:
422:
412:
380:
374:
367:
361:
360:
350:
326:
317:
316:
288:
282:
281:
263:
231:
220:
213:
118:
113:
21:
807:
806:
802:
801:
800:
798:
797:
796:
777:
776:
768:
727:
725:Further reading
722:
721:
714:
704:Riverhead Books
696:
692:
675:
671:
658:
654:
647:
633:
629:
606:
602:
593:
589:
566:
562:
546:
545:
525:
521:
471:
465:
461:
430:
426:
381:
377:
368:
364:
335:Acta Oncologica
327:
320:
289:
285:
232:
223:
214:
205:
200:
151:
116:
111:
104:
90:) than others (
76:
67:
28:
23:
22:
15:
12:
11:
5:
805:
795:
794:
789:
775:
774:
767:
766:External links
764:
763:
762:
751:
742:
726:
723:
720:
719:
712:
690:
669:
652:
645:
627:
600:
587:
560:
535:(2): 193–225.
519:
482:(8): 1283–92.
459:
424:
375:
362:
318:
299:(21): 2311–6.
283:
221:
202:
201:
199:
196:
195:
194:
184:
177:
170:
167:
164:
161:
158:
155:
150:
147:
141:brought on by
103:
100:
75:
72:
66:
63:
33:, also called
26:
9:
6:
4:
3:
2:
804:
793:
790:
788:
785:
784:
782:
773:
770:
769:
760:
759:
755:
752:
750:
747:
743:
741:
737:
733:
729:
728:
715:
713:9781573225304
709:
705:
701:
694:
687:. p. 63.
686:
685:
680:
673:
665:
664:
656:
648:
642:
638:
631:
623:
619:
615:
611:
604:
597:
591:
583:
579:
575:
571:
564:
556:
550:
542:
538:
534:
530:
523:
515:
511:
507:
503:
498:
493:
489:
485:
481:
477:
470:
463:
455:
451:
447:
443:
440:(2): 95–107.
439:
435:
428:
420:
416:
411:
406:
402:
398:
394:
390:
386:
379:
372:
366:
358:
354:
349:
344:
341:(5): 545–50.
340:
336:
332:
325:
323:
314:
310:
306:
302:
298:
294:
287:
279:
275:
271:
267:
262:
257:
253:
249:
245:
241:
237:
230:
228:
226:
218:
212:
210:
208:
203:
192:
188:
185:
182:
179:Turner, in a
178:
175:
174:meta-analysis
172:Hobohm, in a
171:
168:
165:
162:
159:
156:
153:
152:
146:
144:
140:
135:
133:
129:
125:
120:
107:
99:
95:
93:
89:
85:
84:neuroblastoma
81:
71:
62:
60:
56:
52:
48:
44:
40:
36:
32:
19:
756:
745:
744:Uwe Hobohm:
732:Healing Heat
731:
730:Uwe Hobohm:
699:
693:
682:
672:
662:
655:
636:
630:
613:
609:
603:
595:
590:
573:
569:
563:
549:cite journal
532:
528:
522:
479:
475:
462:
437:
433:
427:
395:(3): 421–5.
392:
388:
378:
370:
365:
338:
334:
296:
292:
286:
246:(8): 391–6.
243:
239:
216:
190:
186:
136:
132:angiogenesis
126:
122:
109:
105:
96:
77:
68:
51:blood cancer
38:
34:
30:
29:
576:: 2177–80.
781:Categories
198:References
115:important.
65:Definition
143:infection
128:Apoptosis
92:carcinoma
792:Oncology
734:, 2014,
684:Newsweek
594:Boyd W:
582:14157391
514:26031460
506:23832140
497:11028761
454:18540826
419:15700041
313:19029493
270:11726133
261:11032960
88:lymphoma
80:melanoma
59:palpable
55:leukemia
53:, e.g.,
616:: 5–9.
410:2362074
357:2206563
149:Reviews
738:
710:
643:
622:799760
620:
580:
512:
504:
494:
452:
417:
407:
355:
311:
278:109998
276:
268:
258:
117:
112:
102:Causes
43:cancer
510:S2CID
472:(PDF)
274:S2CID
139:fever
736:ISBN
708:ISBN
641:ISBN
618:PMID
578:PMID
555:link
502:PMID
450:PMID
415:PMID
353:PMID
309:PMID
266:PMID
537:doi
492:PMC
484:doi
442:doi
405:PMC
397:doi
343:doi
301:doi
297:168
256:PMC
248:doi
37:or
783::
706:.
702:.
681:.
614:44
612:.
574:14
572:.
551:}}
547:{{
531:.
508:.
500:.
490:.
480:62
478:.
474:.
448:.
438:28
436:.
413:.
403:.
393:92
391:.
387:.
351:.
339:29
337:.
333:.
321:^
307:.
295:.
272:.
264:.
254:.
244:50
242:.
238:.
224:^
206:^
86:,
82:,
716:.
649:.
624:.
584:.
557:)
539::
533:3
516:.
486::
456:.
444::
421:.
399::
359:.
345::
315:.
303::
280:.
250::
193:"
49:(
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.