1619:
1607:
1594:
483:
339:
1907:
1543:
1816:, a specialized medical care focused on the symptoms, pain, and stress of a serious illness, is recommended by multiple national cancer treatment guidelines as an accompaniment to curative treatments for people with lymphoma. It is used to address both the direct symptoms of lymphoma and many unwanted side effects that arise from treatments. Palliative care can be especially helpful for children who develop lymphoma, helping both children and their families deal with the physical and emotional symptoms of the disease. For these reasons, palliative care is especially important for people requiring bone marrow transplants.
640:
425:
1566:, and IV indicates spread to tissue outside the lymphatic system. Different suffixes imply the involvement of different organs, for example, S for the spleen and H for the liver. Extra-lymphatic involvement is expressed with the letter E. In addition, the presence of B symptoms (one or more of the following: unintentional loss of 10% body weight in the last 6 months, night sweats, or persistent fever of 38 °C or more) or their absence is expressed with B or A, respectively.
739:
1734:. The evidence is very uncertain about the therapeutic effect of mesenchymal stromal cells to treat graft-versus-host diseases on the all-cause mortality and complete disappear of chronic acute graft-versus-host diseases. Mesenchymal stromal cells may result in little to no difference in the all-cause mortality, relapse of malignant disease and incidence of acute and chronic graft-versus-host diseases if they are used for prophylactic reason. Moreover, it was seen that
347:
2003:
34:
1593:
2042:. Clinical/translational research focuses on studying the disease in a defined and generally immediately applicable way, such as testing a new drug in people. Studies may focus on effective means of treatment, better ways of treating the disease, improving the quality of life for people, or appropriate care in remission or after cures. Hundreds of
539:, which are defined as being all lymphomas except Hodgkin lymphoma, are more common than Hodgkin lymphoma. A wide variety of lymphomas are in this class, and the causes, the types of cells involved, and the prognoses vary by type. The number of cases per year of non-Hodgkin lymphoma increases with age. It is further divided into several subtypes.
1618:
1510:. It excluded the Hodgkin lymphomas and divided the remaining lymphomas into four grades (low, intermediate, high, and miscellaneous) related to prognosis, with some further subdivisions based on the size and shape of affected cells. This purely histological classification included no information about
1606:
1824:
Adding physical exercises to the standard treatment for adult patients with haematological malignancies like lymphomas may result in little to no difference in the mortality, the quality of life and the physical functioning. These exercises may result in a slight reduction in depression. Furthermore,
1804:
can be used for the treatment of a
Hodgkin's lymphoma. The evidence is very uncertain about the effect of Nivolumab for patients with a Hodgkin's lymphoma on the overall survival, the quality of life, the survival without a progression, the response rate (=complete disappear) and grade 3 or 4 serious
321:
in the United States for all
Hodgkin lymphoma subtypes is 85%, while that for non-Hodgkin lymphomas is 69%. Worldwide, lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths. They make up 3–4% of all cancers, making them as a group the seventh-most-common form. In children, they are
1561:
is routinely used for staging of both HL and NHL. In this staging system, stage I represents localized disease contained within a lymph node group, II represents the presence of lymphoma in two or more lymph nodes groups, III represents spread of the lymphoma to lymph nodes groups on both sides of
685:
The WHO classification, published in 2001 and updated in 2008, 2017, and 2022, is based upon the foundations laid within the "revised
European–American lymphoma classification" (REAL). This system groups lymphomas by cell type (i.e., the normal cell type that most resembles the tumor) and defining
2049:
Basic science research studies the disease process at a distance, such as seeing whether a suspected carcinogen can cause healthy cells to turn into lymphoma cells in the laboratory or how the DNA changes inside lymphoma cells as the disease progresses. The results from basic research studies are
742:
DNA-microarray analysis of
Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL) showing differences in gene expression patterns. Colors indicate levels of expression; green indicates genes that are underexpressed in lymphoma cells (as compared to normal cells), whereas red indicates genes
490:
According to the World Health
Organization (WHO), lymphoma classification should reflect in which lymphocyte population the neoplasm arises. Thus, neoplasms that arise from precursor lymphoid cells are distinguished from those that arise from mature lymphoid cells. Most mature lymphoid neoplasms
1796:
scans between the chemotherapy cycles can be used to make assumptions about the survival. The evidence is very uncertain about the effect of negative (= good prognosis) or positive (= bad prognosis) interim PET scan results on the progression-free survival. Negative interim PET scan results may
1738:
for people undergoing a chemotherapy or a stem cell transplantation for the prevention of bleeding events had different effects on the number of participants with a bleeding event, the number of days on which a bleeding occurred, the mortality secondary to bleeding and the number of platelet
1722:
regimen. A number of people are cured with first-line chemotherapy. Most relapses occur within the first two years, and the relapse risk drops significantly thereafter. For people who relapse, high-dose chemotherapy followed by autologous stem cell transplantation is a proven approach.
1554:. This refers to determining if the cancer has spread, and if so, whether locally or to distant sites. Staging is reported as a grade between I (confined) and IV (spread). The stage of a lymphoma helps predict a patient's prognosis and is used to help select the appropriate therapy.
1717:
Treatment of some other, more aggressive, forms of lymphoma can result in a cure in the majority of cases, but the prognosis for people with a poor response to therapy is worse. Treatment for these types of lymphoma typically consists of aggressive chemotherapy, including the
1789:. Considerable controversy exists regarding the use of ABVD or BEACOPP. Briefly, both regimens are effective, but BEACOPP is associated with more toxicity. Encouragingly, a significant number of people who relapse after ABVD can still be salvaged by stem cell transplant.
591:
587:
611:
698:
characteristics. The five groups are shown in the table. Hodgkin lymphoma is considered separately within the WHO and preceding classifications, although it is recognized as being a tumor, albeit markedly abnormal, of lymphocytes of mature B cell lineage.
1797:
result in an increase in progression-free survival compared if the adjusted result was measured. Negative interim PET scan results probably result in a large increase in the overall survival compared to those with a positive interim PET scan result.
4306:"Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation"
1525:
In 1994, the
Revised European-American Lymphoma (REAL) classification applied immunophenotypic and genetic features in identifying distinct clinicopathologic entities among all the lymphomas except Hodgkin lymphoma. For coding purposes, the
623:
1650:, a disease wherein these cells' infiltrative lesions are limited to the stomach. These diseases do not progress to cancer, may regress spontaneously and do not respond to, and do not require, chemotherapy or other lymphoma treatments.
1599:
Mantle cell lymphoma: Notice the irregular nuclear contours of the medium-sized lymphoma cells and the presence of a pink histiocyte. By immunohistochemistry, the lymphoma cells expressed CD20, CD5, and Cyclin D1 (high-power view,
603:
1685:
If a low-grade lymphoma becomes symptomatic, radiotherapy or chemotherapy are the treatments of choice. Although these treatments do not permanently cure the lymphoma, they can alleviate the symptoms, particularly painful
1014:
595:
1993:
Because the whole lymphatic system is part of the body's immune system, people with a weakened immune system such as from HIV infection or from certain drugs or medication also have a higher number of cases of lymphoma.
583:
579:
1049:
607:
2985:
Manli Jiang, N. Nora
Bennani, and Andrew L. Feldman. Lymphoma classification update: T-cell lymphomas, Hodgkin lymphoma, and histiocytic/dendritic cell neoplasms. Expert Rev Hematol. 2017 Mar; 10(3): 239–249. Author
1474:
occurs most often in immunocompromised patients, in particular those with AIDS, but it can occur in the immunocompetent, as well. It has a poor prognosis, particularly in those with AIDS. Treatment can consist of
5297:
5278:
3566:
Kirova YM, Piedbois Y, Haddad E, Levy E, Calitchi E, Marinello G, Le
Bourgeois JP (May 1999). "Radiotherapy in the management of mycosis fungoides: indications, results, prognosis. Twenty years experience".
4817:
Schmidt P, Otto M, Hechler T, Metzing S, Wolfe J, Zernikow B (September 2013). "Did increased availability of pediatric palliative care lead to improved palliative care outcomes in children with cancer?".
619:
2316:"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015"
599:
4853:
Tang ST, Chang WC, Chen JS, Wang HM, Shen WC, Li CY, Liao YC (June 2013). "Course and predictors of depressive symptoms among family caregivers of terminally ill cancer patients until their death".
524:
characteristics. A division into
Hodgkin and non-Hodgkin lymphomas is used in several of the older classification systems. A Hodgkin lymphoma is marked by the presence of a type of cell called the
452:
features that may indicate lymphoma. After lymphoma is diagnosed, a variety of tests may be carried out to look for specific features characteristic of different types of lymphoma. These include:
2267:"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015"
491:
comprise the non-Hodgkin lymphomas. Historically, mature histiocytic and dendritic cell (HDC) neoplasms have been considered mature lymphoid neoplasms, since these often involve lymphoid tissue.
4212:"Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition"
2442:
1009:
1587:
are other established poor prognostic factors. This means that people who are elderly or too sick to take care of themselves are more likely to be killed by lymphoma than others.
428:
An initial evaluation of a suspected lymphoma is to make a "touch prep" wherein a glass slide is lightly pressed against excised lymphoid tissue, and subsequently stained (usually
5246:
2050:
generally less immediately useful to people with the disease, but can improve scientists' understanding of lymphoma and form the foundation for future, more effective treatments.
354:
Lymphoma may present with certain nonspecific symptoms; if the symptoms are persistent, an evaluation to determine their cause, including possible lymphoma, should be undertaken.
4774:
Heath JA, Clarke NE, Donath SM, McCarthy M, Anderson VA, Wolfe J (January 2010). "Symptoms and suffering at the end of life in children with cancer: an
Australian perspective".
547:
4655:
3229:
Naresh KN, Medeiros LJ (December 2023). "Introduction to the Fifth Edition of the World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues".
1983:
Taken together, lymphomas represent 5.3% of all cancers (excluding simple basal cell and squamous cell skin cancers) in the United States and 55.6% of all blood cancers.
2163:
1253:
5380:
2566:
Hu L, Luo D, Zhou T, Tao Y, Feng J, Mei S (December 2017). "The association between non-Hodgkin lymphoma and organophosphate pesticides exposure: A meta-analysis".
1580:-avid lymphomas, such as Hodgkin lymphoma, as a staging tool that can even replace bone marrow biopsy. For other lymphomas, CT scanning is recommended for staging.
2106:
1195:
5410:
5309:
2013:
published the first description of lymphoma in 1832, specifically of the form named after him. Since then, many other forms of lymphoma have been described.
2265:
Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, Carter A, et al. (GBD 2015 Disease and Injury Incidence and Prevalence Collaborators) (October 2016).
3710:
1247:
1243:
4261:"Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation"
2190:"Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)"
4210:
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J (January 2019). Cochrane Haematological Malignancies Group (ed.).
1207:
1024:
1678:(growing slowly or not at all) for many years – sometimes, for the rest of the person's life. With an indolent lymphoma, such as follicular lymphoma,
5196:
309:, and surgery. In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so thick that
3031:
2826:
482:
244:
193:
3800:
Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M (November 1971). "Report of the Committee on Hodgkin's Disease Staging Classification".
2519:"The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes"
2433:
1662:
of tumour, referring to how quickly a cancer replicates. Paradoxically, high-grade lymphomas are more readily treated and have better prognoses:
1624:
Hodgkin lymphoma, nodular lymphocyte predominant (high-power view): Notice the presence of L&H cells, also known as "popcorn cells". (H&E)
1499:
Several previous classifications have been used, including Rappaport 1956, Lennert/Kiel 1974, BNLI, Working formulation (1982), and REAL (1994).
1437:
317:
may be appropriate for certain types. The outcome depends on the subtype, with some being curable and treatment prolonging survival in most. The
4560:
Goldkuhle M, Dimaki M, Gartlehner G, Monsef I, Dahm P, Glossmann JP, et al. (July 2018). Cochrane Haematological Malignancies Group (ed.).
5373:
2855:
2658:
Solimini AG, Lombardi AM, Palazzo C, De Giusti M (May 2016). "Meat intake and non-Hodgkin lymphoma: a meta-analysis of observational studies".
4378:
Martin NE, Ng AK (November 2009). "Good things come in small packages: low-dose radiation as palliation for indolent non-Hodgkin lymphomas".
4259:
Estcourt L, Stanworth S, Doree C, Hopewell S, Murphy MF, Tinmouth A, Heddle N (May 2012). Cochrane Haematological Malignancies Group (ed.).
1990:, lymphomas account for about 5%, and Hodgkin lymphoma in particular accounts for less than 1% of all cases of cancer in the United States.
4171:"Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma"
2957:
1825:
aerobic physical exercises probably reduce fatigue. The evidence is very uncertain about the effect on anxiety and serious adverse events.
5057:
Table 1.4: Age-Adjusted SEER Incidence and U.S. Death Rates and 5-Year Relative Survival Rates By Primary Cancer Site, Sex and Time Period
5574:
4304:
Estcourt LJ, Stanworth SJ, Doree C, Hopewell S, Trivella M, Murphy MF (November 2015). Cochrane Haematological Malignancies Group (ed.).
3753:"Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification"
1612:
Hodgkin lymphoma, nodular lymphocyte predominant (low-power view): Notice the nodular architecture and the areas of "mottling". (H&E)
714:, therefore, depends on the correct diagnosis and classification of the disease, which is established after examination of a biopsy by a
2787:
1639:
582:, the World Health Organization (2016) includes the following lymphomas, when associated with EBV infection, in this group of diseases:
4513:"Interim PET-results for prognosis in adults with Hodgkin lymphoma: a systematic review and meta-analysis of prognostic factor studies"
3706:
3112:
2896:
2611:"Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma: A PRISMA-Compliant Meta-Analysis of Observational Studies"
2414:
930:
775:
Occurs in older adults, usually involves lymph nodes, bone marrow and spleen, most patients have peripheral blood involvement, indolent
3629:"Expert review of non-Hodgkin's lymphomas in a population-based cancer registry: reliability of diagnosis and subtype classifications"
5366:
5175:
1635:
1124:
1109:
1739:
transfusions depending on the way they were used (therapeutic, depending on a threshold, different dose schedules or prophylactic).
5581:
4964:
Knips L, Bergenthal N, Streckmann F, Monsef I, Elter T, Skoetz N (January 2019). Cochrane Haematological Malignancies Group (ed.).
2996:
Canova F, Marino D, Trentin C, SoldĂ C, Ghiotto C, Aversa SM (August 2011). "Intrathecal chemotherapy in lymphomatous meningitis".
1082:
Endemic in Africa, sporadic elsewhere, more common in immunocompromised and children, often visceral involvement, highly aggressive
834:
710:), causing rapid deterioration and death. However, most of the aggressive lymphomas respond well to treatment and are curable. The
4673:
3685:
3081:
3950:"A Systematic Review on Childhood Non-Hodgkin Lymphoma: An Overlooked Phenomenon in the Health and Research Sector of Bangladesh"
3266:"A Systematic Review on Childhood Non-Hodgkin Lymphoma: An Overlooked Phenomenon in the Health and Research Sector of Bangladesh"
3129:"A Systematic Review on Childhood Non-Hodgkin Lymphoma: An Overlooked Phenomenon in the Health and Research Sector of Bangladesh"
1727:
1471:
1272:
1267:
649:
3336:
2719:
5507:
5430:
3358:
1129:
5013:
4511:
Aldin A, Umlauff L, Estcourt LJ, Collins G, Moons KG, Engert A, et al. (January 2020). Cochrane Haematology Group (ed.).
3079:
National Cancer Institute. "What You Need To Know About Hodgkin Lymphoma". U.S. Dept of Health and Human Services, (online at
3058:
2155:
1777:
Advanced Hodgkin disease requires systemic chemotherapy, sometimes combined with radiotherapy. Chemotherapy used includes the
338:
290:
may then be done to determine if and where the cancer has spread. Lymphoma most often spreads to the lungs, liver, and brain.
4669:
4651:
3611:
3505:
3330:
2810:
2781:
2754:
2408:
2244:
1303:
3511:
1642:) can be mimicked by two benign diseases that involve the excessive proliferation of nonmalignant NK cells in the GI tract,
5598:
2801:
Tepper John E. Niederhuber, James O. Armitage, James H. Doroshow, Michael B. Kastan, Joel E. (2014). "Childhood lymphoma".
1906:
4943:
3186:
Rezk SA, Zhao X, Weiss LM (September 2018). "Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update".
2495:
4134:
Jenkins EC (January 1972). "Wire-loop application of liquid emulsion to slides for autoradiography in light microscopy".
2098:
1029:
875:
748:
4753:
1781:
regimen, which is commonly used in the United States. Other regimens used in the management of Hodgkin lymphoma include
5564:
1234:
615:
466:
5591:
5524:
5519:
5460:
5455:
5137:
5093:
Tran H, Nourse J, Hall S, Green M, Griffiths L, Gandhi MK (September 2008). "Immunodeficiency-associated lymphomas".
2381:
1277:
3316:
5044:
4091:
Bernstein SH, Burack WR (2009). "The incidence, natural history, biology, and treatment of transformed lymphomas".
791:
5638:
5475:
5450:
5251:
1658:
Prognoses and treatments are different for HL and between all the different forms of NHL, and also depend on the
1647:
1643:
1542:
4611:"The national agenda for quality palliative care: the National Consensus Project and the National Quality Forum"
5569:
5539:
5490:
5485:
5440:
5425:
3527:"Burkitt lymphoma in adults: a prospective study of 72 patients treated with an adapted pediatric LMB protocol"
1682:
is often the initial course of action, because monitoring is less risky and less harmful than early treatment.
1239:
1119:
1104:
797:
782:
3874:"NK-Cell Enteropathy and Similar Indolent Lymphoproliferative Disorders: A Case Series With Literature Review"
367:(systemic symptoms) – can be associated with both Hodgkin lymphoma and non-Hodgkin lymphoma. They consist of:
5669:
5613:
5445:
1987:
1690:. People with these types of lymphoma can live near-normal lifespans, even though the disease is technically
1134:
973:
578:(EBV). The virus may be responsible for the development and/or progression of these diseases. In addition to
5643:
5554:
5465:
3127:
Britto TI, Fattah SA, Rahman MA, Chowdhury MA, Britto TI, Fattah SA, Rahman MA, Chowdhury MA (2023-09-25).
1793:
1646:, a disease wherein NK cell infiltrative lesions occur in the intestine, colon, stomach, or esophagus, and
1287:
959:
267:
254:
and a history of the disease in the family. Risk factors for common types of non-Hodgkin lymphomas include
5608:
5207:
4702:"What is the evidence that palliative care teams improve outcomes for cancer patients and their families?"
1666:, for example, is a high-grade tumour known to double within days, and is highly responsive to treatment.
5534:
5497:
5480:
1300:
with irregular nuclear contours, condensed chromatin, small nucleoli and scant cytoplasm without granules
1114:
1034:
1019:
5679:
5618:
5514:
2188:
Kamper-Jørgensen M, Rostgaard K, Glaser SL, Zahm SH, Cozen W, Smedby KE, et al. (September 2013).
915:
Occurs in older adults, usually involves lymph nodes, bone marrow and spleen, associated with t(14;18)
787:
703:
263:
4940:"Providing Palliative Care to Family Caregivers Throughout the Bone Marrow Transplantation Trajectory"
1730:. It was evaluated whether mesenchymal stromal cells can be used for the treatment and prophylaxis of
760:
Small resting lymphocytes mixed with variable numbers of large activated cells, lymph nodes diffusely
516:
Hodgkin lymphoma accounts for about 15% of lymphomas. It differs from other forms of lymphomas in its
5603:
5153:
5040:
3437:
Herrmann A, Hoster E, Zwingers T, Brittinger G, Engelhard M, Meusers P, et al. (February 2009).
1759:
1731:
1370:
Reed–Sternberg cell variants and inflammation, usually broad sclerotic bands that consist of collagen
1044:
916:
4169:
Philip T, Guglielmi C, Hagenbeek A, Somers R, Van der Lelie H, Bron D, et al. (December 1995).
2938:
2851:
2473:
5633:
5544:
5502:
5470:
5420:
5317:
5069:
3826:
1977:
1747:
1416:
Most common in men, more likely to be diagnosed at advanced stages than the nodular sclerosis form
1139:
4649:*The American Society of Clinical Oncology made this recommendation based on various cancers. See
3751:
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA (September 2014).
1160:
Usually small lymphoid cells with convoluted nuclei that often infiltrate the epidermis, creating
5623:
5586:
5559:
5549:
4354:
3725:"2022 ICD-10-CM Codes C81-C96: Malignant neoplasms of lymphoid, hematopoietic and related tissue"
1751:
1726:
The treatment of side effects is also important as they can occur due to the chemotherapy or the
1171:
1161:
996:
525:
370:
318:
4562:"Nivolumab for adults with Hodgkin's lymphoma (a rapid review using the software RobotReviewer)"
4462:
Viviani S, Zinzani PL, Rambaldi A, Brusamolino E, Levis A, Bonfante V, et al. (July 2011).
3525:
Diviné M, Casassus P, Koscielny S, Bosq J, Sebban C, Le Maignan C, et al. (December 2005).
2953:
1002:
Occurs in all ages, but most commonly in older adults, may occur outside lymph nodes, aggressive
706:), compatible with a long life even without treatment, whereas other forms are aggressive (e.g.
5628:
5435:
5415:
5405:
2035:
1417:
1291:
1200:
1177:
Localized or more generalized skin symptoms, generally indolent, in a more aggressive variant,
1039:
855:
761:
575:
495:
283:
251:
101:
5346:
2517:
Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, et al. (July 2009).
1178:
361:
or swelling of lymph nodes, is the primary presentation in lymphoma. It is generally painless.
2925:
1577:
1067:
1054:
707:
5358:
2892:
2771:
2398:
2373:
2367:
639:
5171:
2575:
1774:
Hodgkin lymphoma typically is treated with radiotherapy alone, as long as it is localized.
1763:
1735:
1511:
1507:
935:
827:
536:
232:
3724:
2917:
1227:
Probably consists of several rare tumor types, often disseminated and generally aggressive
278:
may also increase the risk. Diagnosis, if enlarged lymph nodes are present, is usually by
8:
5674:
5301:
3668:
3372:
2059:
1719:
1503:
1387:
1096:
880:
813:
802:
41:
3984:
3949:
3292:
3265:
3163:
3128:
3088:
2579:
1750:(for relapsed or refractory large B-cell lymphoma with two failed systemic treatments),
4990:
4965:
4921:
4878:
4799:
4787:
4731:
4609:
Ferrell B, Connor SR, Cordes A, Dahlin CM, Fine PG, Hutton N, et al. (June 2007).
4586:
4561:
4537:
4512:
4493:
4403:
4330:
4305:
4281:
4260:
4236:
4211:
4116:
4038:
3903:
3777:
3752:
3468:
3211:
2820:
2693:
2635:
2610:
2548:
2461:
2340:
2315:
2291:
2266:
2214:
2189:
1584:
1563:
396:
255:
225:
164:
105:
89:
68:
5529:
4627:
4610:
4069:
3580:
2331:
2282:
1148:
228:. The enlarged lymph nodes are usually painless. The sweats are most common at night.
5664:
5133:
5110:
4995:
4913:
4870:
4835:
4791:
4723:
4632:
4591:
4542:
4485:
4444:
4395:
4335:
4286:
4241:
4192:
4151:
4108:
4073:
4030:
3989:
3971:
3930:
3895:
3850:
3809:
3782:
3700:
3650:
3607:
3584:
3548:
3501:
3460:
3424:
3326:
3320:
3297:
3246:
3203:
3168:
3150:
3106:
3013:
3009:
2806:
2777:
2750:
2685:
2640:
2591:
2540:
2404:
2377:
2345:
2296:
2219:
1675:
1558:
1355:
1219:
Variable, usually a mix small to large lymphoid cells with irregular nuclear contours
1144:
456:
441:
401:
298:
279:
139:
125:
120:
52:
5017:
4925:
4882:
4735:
4497:
4439:
4422:
4407:
4120:
4104:
4042:
3907:
3472:
3350:
3215:
3054:
2697:
958:
Occurs mainly in adult males, usually involves lymph nodes, bone marrow, spleen and
868:
Frequently occurs outside lymph nodes, very indolent, may be cured by local excision
5102:
4985:
4981:
4977:
4905:
4862:
4827:
4803:
4783:
4713:
4622:
4581:
4577:
4573:
4532:
4528:
4524:
4475:
4434:
4387:
4325:
4321:
4317:
4276:
4272:
4268:
4231:
4227:
4223:
4182:
4143:
4100:
4065:
4020:
3979:
3961:
3885:
3869:
3840:
3772:
3764:
3640:
3576:
3538:
3450:
3414:
3401:
Leitch HA, Gascoyne RD, Chhanabhai M, Voss NJ, Klasa R, Connors JM (October 2003).
3287:
3277:
3238:
3195:
3158:
3140:
3005:
2675:
2667:
2630:
2622:
2583:
2552:
2530:
2335:
2327:
2286:
2278:
2240:
2209:
2201:
1755:
1702:
1679:
1663:
1349:
1317:
1222:
511:
433:
327:
314:
306:
236:
231:
Many subtypes of lymphomas are known. The two main categories of lymphomas are the
201:
147:
4056:
Ansell SM (April 2014). "Follicular lymphoma: watch and wait is watch and worry".
3827:
International Non-Hodgkin's Lymphoma Prognostic Factors Project (September 1993).
3645:
3628:
3199:
2711:
1705:
is not a desirable strategy for everyone, as it leads to significant distress and
1522:. It was widely accepted at the time of its publication but by 2004 was obsolete.
1015:
Epstein–Barr virus positive diffuse large B-cell lymphoma, not otherwise specified
5322:
5241:
4718:
4701:
4664:
3500:. Vol. 936 (4 ed.). Lippincott Williams & Wilkins. pp. 285–6.
3495:
3242:
2587:
2535:
2518:
2043:
1813:
1701:
in the treatment of follicular lymphoma rather than the wait-and-watch approach.
1687:
1519:
1515:
1476:
1050:
Large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease
986:
Variable, most resemble B cells of large germinal centers, diffuse growth pattern
719:
358:
323:
287:
275:
209:
113:
73:
4187:
4170:
3921:
Sweetenham JW (November 2009). "Treatment of lymphoblastic lymphoma in adults".
3845:
3828:
3627:
Clarke CA, Glaser SL, Dorfman RF, Bracci PM, Eberle E, Holly EA (January 2004).
2626:
2487:
5106:
4966:"Aerobic physical exercise for adult patients with haematological malignancies"
4939:
2039:
2010:
1659:
1551:
907:
767:
555:
461:
449:
310:
302:
143:
4464:"ABVD versus BEACOPP for Hodgkin's lymphoma when high-dose salvage is planned"
4391:
4147:
2671:
5658:
5236:
4749:
4009:"Understanding the concept of uncertainty in patients with indolent lymphoma"
3975:
3768:
3455:
3438:
3154:
950:
838:
666:
656:
542:
424:
5291:
5287:
3543:
3526:
3419:
3402:
2609:
Yang L, Dong J, Jiang S, Shi W, Xu X, Huang H, et al. (November 2015).
2205:
5390:
5114:
4999:
4917:
4896:
Chung HM, Lyckholm LJ, Smith TJ (February 2009). "Palliative care in BMT".
4874:
4839:
4795:
4727:
4636:
4595:
4546:
4489:
4448:
4399:
4339:
4290:
4245:
4112:
4077:
4034:
4025:
4008:
3993:
3934:
3899:
3786:
3654:
3588:
3552:
3464:
3428:
3301:
3250:
3207:
3172:
3017:
2689:
2644:
2595:
2544:
2349:
2300:
2223:
1484:
1480:
1465:
819:
660:
551:
429:
375:
294:
135:
4831:
4480:
4463:
4196:
4155:
3890:
3873:
3854:
3813:
738:
5341:
5032:
4909:
3966:
3282:
3145:
1576:
imaging modalities are used to stage cancer. PET scanning is advised for
1383:
1297:
897:
851:
807:
695:
380:
217:
96:
81:
3439:"Improvement of overall survival in advanced stage mantle cell lymphoma"
2680:
346:
2002:
1910:
Deaths from lymphomas and multiple myeloma per million persons in 2012
1786:
1743:
1331:
893:
687:
571:
445:
364:
197:
57:
45:
5270:
1273:
B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
702:
Of the many forms of lymphoma, some are categorized as indolent (e.g.
208:
versions rather than all such tumours. Signs and symptoms may include
4866:
3673:
3377:
1801:
1698:
1691:
1192:
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders
1071:
963:
715:
711:
691:
521:
517:
271:
158:
947:
Lymphocytes of small to intermediate size growing in diffuse pattern
2187:
1766:). These therapies come with certification and other restrictions.
1573:
1182:
567:
499:
259:
240:
221:
109:
85:
61:
1010:
Diffuse large B-cell lymphoma associated with chronic inflammation
592:
diffuse large B cell lymphoma associated with chronic inflammation
4650:
4461:
1782:
1706:
1569:
1066:
Round lymphoid cells of intermediate size with several nucleoli,
563:
559:
411:
406:
151:
33:
3436:
2657:
574:) in which one or more of these cell types is infected with the
5282:
5255:
4963:
4559:
1746:
therapies are FDA-approved for non-Hodgkin lymphoma, including
1326:
1321:
1092:
731:
390:
205:
4303:
4258:
4168:
486:
Lymph node with mantle cell lymphoma (low-power view, H&E)
5388:
4427:
Hematology. American Society of Hematology. Education Program
4093:
Hematology. American Society of Hematology. Education Program
3799:
3750:
1527:
920:
213:
77:
3400:
3319:. In Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (eds.).
4510:
3947:
3602:
Jaffe ES, Harris NL, Vardiman JW, Campo E, Arber D (2011).
3524:
3263:
3126:
2516:
1778:
1377:
1373:
990:
903:
862:
322:
the third-most-common cancer. They occur more often in the
4209:
3829:"A predictive model for aggressive non-Hodgkin's lymphoma"
3264:
Britto TI, Fattah SA, Rahman M, Chowdhury M (2023-09-25).
2776:(Second ed.). Cambridge University Press. p. 1.
2749:. World Health Organization. 2014. pp. Chapter 5.13.
2435:
The Lymphoma Guide Information for Patients and Caregivers
858:
of B cells to epithelium creates lymphoepithelial lesions.
548:
Epstein–Barr virus-associated lymphoproliferative diseases
543:
Epstein–Barr virus-associated lymphoproliferative diseases
5172:"Search of: Lymphoma - List Results - ClinicalTrials.gov"
4816:
4773:
4608:
3626:
1531:
1455:
1446:
Immunodeficiency-associated lymphoproliferative disorders
1311:
1307:
1268:
B-lymphoblastic leukemia/lymphoma not otherwise specified
1166:
250:
Risk factors for Hodgkin lymphoma include infection with
3601:
3565:
2995:
2918:"Primary CNS Lymphoma: Overview, Etiology, Epidemiology"
962:, associated with t(11;14) translocation overexpressing
448:
examined under the microscope. This examination reveals
4355:"New CAR-T for Aggressive B-Cell Lymphoma Wins FDA Nod"
749:
B-cell chronic lymphocytic leukemia/small cell lymphoma
5127:
4750:"Palliative Care: It's for Caregivers Too, Says Study"
3948:
Britto TI, Fattah SA, Rahman MA, Chowdhury MA (2023).
3387:
3385:
2313:
2264:
2156:"General Information About Adult Non-Hodgkin Lymphoma"
1709:
in some people. It has been called "watch and worry".
1254:
Breast plant-associated anaplastic large cell lymphoma
4656:"Five Things Physicians and Patients Should Question"
3867:
2893:"Warning Signs of Lymphoma — First Signs of Lymphoma"
2887:
2885:
2883:
2881:
2879:
2877:
2875:
2873:
342:
The lymph nodes where lymphoma most commonly develops
5260:
293:
Treatment may involve one or more of the following:
5092:
5030:
3382:
2034:The two types of lymphoma research are clinical or
1546:
Diagram showing common sites where lymphoma spreads
612:
peripheral T cell lymphoma, not otherwise specified
4895:
2870:
2773:Lymphoma : pathology, diagnosis and treatment
2099:"General Information About Adult Hodgkin Lymphoma"
2046:are being planned or conducted at any given time.
1836:Five-year relative survival by stage at diagnosis
1550:After a diagnosis and before treatment, cancer is
1454:Associated with the human immunodeficiency virus (
1410:Many classic Reed–Sternberg cells and inflammation
1208:Peripheral T-cell lymphoma not otherwise specified
1025:Primary mediastinal (thymic) large B-cell lymphoma
393:, bleeding, increased susceptibility to infections
5197:"Understanding Clinical Trials for Blood Cancers"
4852:
2372:(29th ed.). Philadelphia: Saunders. p.
1382:Most common in young adults, often arises in the
850:Variable cell size and differentiation, 40% show
5656:
5132:. Lippincott Williams & Wilkins. p. 5.
5128:Hellman S, Mauch, P.M. Ed. (1999). "Chapter 1".
5037:Surveillance Epidemiology and End Results (SEER)
3633:Cancer Epidemiology, Biomarkers & Prevention
2805:(Fifth ed.). Elsevier. p. Chapter 97.
2608:
1196:Primary cutaneous anaplastic large cell lymphoma
900:), usually nodular ("follicular") growth pattern
245:tumors of the hematopoietic and lymphoid tissues
243:and myelomas are a part of the broader group of
5206:. Leukemia and Lymphoma Society. Archived from
4695:
4693:
4423:"Standard therapy of advanced Hodgkin lymphoma"
4090:
3709:) CS1 maint: bot: original URL status unknown (
3322:Cancer Management: A Multidisciplinary Approach
3052:National Cancer Institute, "Hodgkin Lymphoma",
2846:
2844:
2842:
2840:
2838:
2836:
1438:Nodular lymphocyte-predominant Hodgkin lymphoma
596:fibrin-associated diffuse large B cell lymphoma
4699:
3228:
2945:
1697:Some centers advocate the use of single agent
1640:type II enteropathy-associated T-cell lymphoma
588:large B cell lymphoma, not otherwise specified
5374:
3688:. Archived from the original on June 27, 2004
3185:
2712:"SEER Stat Fact Sheets: Non-Hodgkin Lymphoma"
2428:
2426:
2424:
2396:
1980:, or "blood cancer", in the developed world.
824:Monoclonal immunoglobulin deposition diseases
4889:
4846:
4810:
4767:
4690:
4602:
4414:
4371:
4084:
4000:
3914:
3861:
3595:
3257:
3179:
2833:
2825:: CS1 maint: multiple names: authors list (
2565:
2403:. Jones & Bartlett Learning. p. 6.
1835:
1514:or genetics and made no distinction between
4970:The Cochrane Database of Systematic Reviews
4566:The Cochrane Database of Systematic Reviews
4517:The Cochrane Database of Systematic Reviews
4310:The Cochrane Database of Systematic Reviews
4265:The Cochrane Database of Systematic Reviews
4216:The Cochrane Database of Systematic Reviews
2017:
1494:
1407:Second-most common form of Hodgkin lymphoma
444:, meaning a partial or total excision of a
16:Hematologic cancer that affects lymphocytes
5381:
5367:
5033:"SEER Cancer Statistics Review, 1975–2006"
3920:
3497:Clinical Hematology: Theory and Procedures
3314:
2741:
2739:
2737:
2421:
2150:
2148:
2146:
2144:
1867:Regional (spread to regional lymph nodes)
931:Primary cutaneous follicle center lymphoma
665:. Relevant discussion may be found on the
32:
5121:
5031:Horner MJ, Ries LG, Krapcho M, Neyman N.
4989:
4717:
4626:
4585:
4536:
4479:
4438:
4420:
4329:
4280:
4235:
4186:
4024:
3983:
3965:
3889:
3872:, Ferry JA, Zukerberg LR (January 2019).
3844:
3776:
3746:
3744:
3644:
3542:
3454:
3418:
3291:
3281:
3162:
3144:
2679:
2634:
2534:
2400:Johns Hopkins Patients' Guide to Lymphoma
2339:
2290:
2258:
2213:
2183:
2181:
2142:
2140:
2138:
2136:
2134:
2132:
2130:
2128:
2126:
2124:
2093:
1636:extranodal NK/T-cell lymphoma, nasal type
1629:
1451:Associated with a primary immune disorder
1157:Most common cutaneous lymphoid malignancy
1125:Extranodal NK/T-cell lymphoma, nasal type
1110:T-cell large granular lymphocyte leukemia
1063:< 1% of lymphomas in the United States
743:that are overexpressed in lymphoma cells.
608:extranodal NK/T cell lymphoma, nasal type
502:, known as lymphomatous meningitis (LM).
204:). The name typically refers to just the
5411:Attention deficit hyperactivity disorder
5245:) is being considered for deletion. See
4377:
2369:Dorland's Illustrated medical dictionary
2307:
2241:"Hodgkin Lymphoma—SEER Stat Fact Sheets"
2091:
2089:
2087:
2085:
2083:
2081:
2079:
2077:
2075:
2073:
2001:
1905:
1541:
835:Extranodal marginal zone B cell lymphoma
737:
531:
481:
440:Lymphoma is definitively diagnosed by a
423:
345:
337:
4133:
3493:
3487:
2998:Critical Reviews in Oncology/Hematology
2763:
2734:
2361:
2359:
1819:
1472:Primary central nervous system lymphoma
274:. Eating large amounts of red meat and
5657:
5047:from the original on 26 September 2009
4663:Choosing Wisely: an initiative of the
4615:Journal of Pain and Symptom Management
4352:
4055:
4006:
3878:American Journal of Clinical Pathology
3741:
3705:: CS1 maint: archived copy as title (
3111:: CS1 maint: archived copy as title (
2800:
2769:
2365:
2235:
2233:
2178:
2121:
1130:Enteropathy-associated T-cell lymphoma
5362:
4670:American Society of Clinical Oncology
4652:American Society of Clinical Oncology
2981:
2979:
2977:
2975:
2070:
1856:Localized (confined to primary site)
1769:
629:
624:systemic T cell lymphoma of childhood
333:
286:may also be useful in the diagnosis.
3403:"Limited-stage mantle-cell lymphoma"
2960:from the original on 16 January 2013
2858:from the original on 2 December 2012
2356:
2314:Wang H, et al. (October 2016).
1976:Lymphoma is the most common form of
1367:Most common type of Hodgkin lymphoma
1070:by diffuse spread with interspersed
896:) mixed with large activated cells (
633:
313:is performed to remove the protein.
5508:Epidemiology of Alzheimer's disease
5204:The Leukemia & Lymphoma Society
4468:The New England Journal of Medicine
4175:The New England Journal of Medicine
3833:The New England Journal of Medicine
3606:(1st ed.). Elsevier Saunders.
2951:
2230:
1800:Current research evaluated whether
1432:Lymphocyte depleted or not depleted
1030:Intravascular large B-cell lymphoma
983:About 40–50% of lymphomas in adults
876:Nodal marginal zone B cell lymphoma
505:
13:
4788:10.5694/j.1326-5377.2010.tb03420.x
2972:
2016:The term "lymphoma" is from Latin
1988:U.S. National Institutes of Health
1878:Distant (cancer has metastasized)
1808:
1398:Mixed cellularity Hodgkin lymphoma
1235:Angioimmunoblastic T-cell lymphoma
616:angioimmunoblastic T-cell lymphoma
14:
5691:
5249:to help reach a consensus. ›
5228:
5014:"SEER Stat Fact Sheets: Lymphoma"
4628:10.1016/j.jpainsymman.2007.02.024
3317:"Principles of Surgical Oncology"
2448:from the original on 14 July 2014
1758:(for large B-cell lymphoma), and
1330:mutations, and is most common in
1278:T-lymphoblastic leukemia/lymphoma
944:About 3–4% of lymphomas in adults
477:
4776:The Medical Journal of Australia
3514:from the original on 2015-09-06.
3361:from the original on 2010-07-04.
3339:from the original on 2013-10-04.
3010:10.1016/j.critrevonc.2010.07.005
2854:. Lymphoma Research Foundation.
2790:from the original on 2015-09-06.
2722:from the original on 6 July 2014
2498:from the original on 5 July 2014
2417:from the original on 2017-09-10.
2166:from the original on 5 July 2014
2109:from the original on 5 July 2014
2053:
1744:chimeric antigen receptor T cell
1674:Many low-grade lymphomas remain
1617:
1605:
1592:
1506:of 1982 was a classification of
1185:and peripheral blood involvement
889:About 40% of lymphomas in adults
816:(also known as multiple myeloma)
638:
498:, often around the brain in the
494:Lymphoma can also spread to the
5189:
5178:from the original on 2013-01-06
5164:
5146:
5086:
5062:
5024:
5006:
4957:
4946:from the original on 2013-08-12
4932:
4756:from the original on 2014-06-01
4742:
4700:Higginson IJ, Evans CJ (2010).
4643:
4553:
4504:
4455:
4440:10.1182/asheducation-2009.1.497
4346:
4297:
4252:
4203:
4162:
4127:
4105:10.1182/asheducation-2009.1.532
4049:
3941:
3820:
3793:
3717:
3678:
3661:
3620:
3559:
3518:
3365:
3343:
3308:
3222:
3120:
3073:
3061:from the original on 2013-08-02
3046:
3024:
2989:
2910:
2899:from the original on 2012-11-18
2794:
2704:
2651:
2602:
2559:
2510:
2480:
2247:from the original on 2012-10-17
1901:
1894:
1891:
1888:
1883:
1880:
1877:
1872:
1869:
1866:
1861:
1858:
1855:
1848:
1843:
1840:
1644:natural killer cell enteropathy
1534:(codes C81-C96) are available.
1324:. It is highly associated with
847:About 5% of lymphomas in adults
407:Respiratory distress or dyspnea
4982:10.1002/14651858.CD009075.pub3
4820:Journal of Palliative Medicine
4578:10.1002/14651858.CD012556.pub2
4529:10.1002/14651858.CD012643.pub3
4322:10.1002/14651858.CD010983.pub2
4273:10.1002/14651858.CD004269.pub3
4228:10.1002/14651858.CD009768.pub2
3355:The Merck Manual of Geriatrics
2390:
1320:because of involvement of the
1240:Anaplastic large cell lymphoma
1120:Adult T-cell leukemia/lymphoma
1105:T-cell prolymphocytic leukemia
798:Splenic marginal zone lymphoma
783:B-cell prolymphocytic leukemia
652:of this section is in question
580:EBV-positive Hodgkin lymphomas
1:
5234:
4070:10.1016/S1470-2045(14)70066-X
3646:10.1158/1055-9965.EPI-03-0250
3581:10.1016/S0167-8140(99)00050-X
3200:10.1016/j.humpath.2018.05.020
3032:"Hodgkins Lymphoma Incidence"
2332:10.1016/s0140-6736(16)31012-1
2283:10.1016/S0140-6736(16)31678-6
2064:
1792:Scientists evaluated whether
1712:
1135:Hepatosplenic T-cell lymphoma
974:Diffuse large B-cell lymphoma
792:Waldenström macroglobulinemia
659:can not read content that is
350:Lymphoma and lymphatic system
268:immunosuppressant medications
4719:10.1097/PPO.0b013e3181f684e5
3868:Xia D, Morgan EA, Berger D,
3757:Journal of Clinical Oncology
3443:Journal of Clinical Oncology
3325:(11th ed.). CMPMedica.
3243:10.1016/j.modpat.2023.100330
2954:"How Is Lymphoma Diagnosed?"
2588:10.1016/j.envpol.2017.08.028
2536:10.1182/blood-2009-03-209262
1828:
1794:positron emission tomography
1669:
1653:
1288:acute lymphoblastic leukemia
1262:Precursor lymphoid neoplasms
725:Lymphoma subtypes (WHO 2008)
554:, and malignant diseases of
419:
397:Loss of appetite or anorexia
7:
5158:Online Etymology Dictionary
4898:Bone Marrow Transplantation
4188:10.1056/nejm199512073332305
3846:10.1056/NEJM199309303291402
2803:Abeloff's clinical oncology
2660:Cancer Causes & Control
2627:10.1097/MD.0000000000001729
2029:
1216:Most common T cell lymphoma
1115:Aggressive NK cell leukemia
1079:Five-year survival rate 50%
1020:Lymphomatoid granulomatosis
757:3–4% of lymphomas in adults
572:histiocytic-dendritic cells
10:
5696:
5107:10.1016/j.blre.2008.03.009
3055:"Lymphoma—Patient Version"
2057:
2026:("morbid growth, tumor").
1997:
1732:graft-versus-host diseases
1537:
1487:, often with methotrexate.
1035:ALK+ large B-cell lymphoma
788:Lymphoplasmacytic lymphoma
704:small lymphocytic lymphoma
620:follicular T cell lymphoma
509:
264:human T-lymphotropic virus
220:, unintended weight loss,
84:, unintended weight loss,
5398:
5332:
5264:
5041:National Cancer Institute
4392:10.3109/10428190903186510
4148:10.3109/10520297209116530
3569:Radiotherapy and Oncology
2672:10.1007/s10552-016-0745-2
2160:National Cancer Institute
2103:National Cancer Institute
2022:("water") and from Greek
1760:brexucabtagene autoleucel
1728:stem cell transplantation
1162:Pautrier microabscesseses
1055:Burkitt lymphoma/leukemia
1045:Primary effusion lymphoma
976:, not otherwise specified
772:5-year survival rate 50%.
654:. The specific issue is:
600:primary effusion lymphoma
235:(NHL) (90% of cases) and
179:
171:
157:
131:
119:
95:
67:
51:
40:
31:
26:
5582:Motor vehicle collisions
5247:templates for discussion
3769:10.1200/JCO.2013.54.8800
3456:10.1200/JCO.2008.16.8435
3435:70% for advanced stage:
3070:, accessed on 2013-08-05
2747:World Cancer Report 2014
1978:hematological malignancy
1748:lisocabtagene maraleucel
1648:lymphomatoid gastropathy
1559:Ann Arbor staging system
1495:Previous classifications
1420:involved in 70% of cases
1358:form of Hodgkin lymphoma
1140:Blastic NK cell lymphoma
892:Small "cleaved" cells (
239:(HL) (10%). Lymphomas,
5074:American Cancer Society
4380:Leukemia & Lymphoma
4353:Ingram I (2021-02-05).
3399:50% for limited stage:
2568:Environmental Pollution
1752:axicabtagene ciloleucel
1316:It often presents as a
997:Five-year survival rate
989:Variable expression of
966:, moderately aggressive
550:are a group of benign,
432:) for evaluation under
319:five-year survival rate
5431:Cardiovascular disease
4026:10.1188/08.ONF.449-454
4013:Oncology Nursing Forum
4007:Elphee EE (May 2008).
2956:. lymphoma.about.com.
2933:Cite journal requires
2895:. Lymphoma.about.com.
2397:Aditya Bardia (2010).
2036:translational research
2018:
2007:
1973:
1630:Differential diagnosis
1547:
1530:(codes 9590–9999) and
1292:lymphoblastic lymphoma
1201:Lymphomatoid papulosis
1040:Plasmablastic lymphoma
744:
604:plasmablastic lymphoma
496:central nervous system
487:
437:
351:
343:
194:blood and lymph tumors
5609:Risky sexual behavior
5393:of medical conditions
4832:10.1089/jpm.2013.0014
4481:10.1056/NEJMoa1100340
3544:10.1093/annonc/mdi403
3420:10.1093/annonc/mdg414
2206:10.1093/annonc/mdt218
2005:
1909:
1736:platelet transfusions
1545:
1068:starry-sky appearance
741:
537:Non-Hodgkin lymphomas
532:Non-Hodgkin lymphomas
485:
427:
349:
341:
5670:Anatomical pathology
5599:Periodontal diseases
4910:10.1038/bmt.2008.436
4421:Kuruvilla J (2009).
4359:www.medpagetoday.com
4058:The Lancet. Oncology
3967:10.7759/cureus.45937
3669:Non-Hodgkin Lymphoma
3373:Lymphoma, Follicular
3283:10.7759/cureus.45937
3146:10.7759/cureus.45937
2326:(10053): 1459–1544.
2277:(10053): 1545–1602.
1820:Supportive treatment
1764:mantle cell lymphoma
1512:cell surface markers
1508:non-Hodgkin lymphoma
1388:cervical lymph nodes
936:Mantle cell lymphoma
828:Heavy chain diseases
282:. Blood, urine, and
233:non-Hodgkin lymphoma
210:enlarged lymph nodes
74:Enlarged lymph nodes
3891:10.1093/ajcp/aqy108
3494:Turgeon ML (2005).
3351:"Chronic Leukemias"
3315:Wagman LD. (2008).
2580:2017EPoll.231..319H
2243:. Seer.cancer.gov.
2060:Lymphoma in animals
1889:Unknown (unstaged)
1841:Stage at diagnosis
1634:Certain lymphomas (
1504:Working Formulation
1099:(NK) cell neoplasms
881:Follicular lymphoma
814:Plasma cell myeloma
803:Hairy cell leukemia
526:Reed–Sternberg cell
284:bone marrow testing
256:autoimmune diseases
106:autoimmune diseases
42:Follicular lymphoma
5565:Metabolic syndrome
5333:External resources
5070:"Hodgkin Lymphoma"
3531:Annals of Oncology
3407:Annals of Oncology
2366:Taylor EJ (2000).
2194:Annals of Oncology
2008:
1974:
1844:Five-year relative
1585:performance status
1578:fluorodeoxyglucose
1548:
1418:Epstein–Barr virus
745:
708:Burkitt's lymphoma
630:WHO classification
576:Epstein–Barr virus
488:
438:
352:
344:
334:Signs and symptoms
252:Epstein–Barr virus
196:that develop from
175:4.9 million (2015)
165:five year survival
102:Epstein–Barr virus
5680:Pediatric cancers
5652:
5651:
5639:Teenage pregnancy
5525:Domestic violence
5520:Diabetes mellitus
5356:
5355:
5213:on 5 January 2011
5130:Hodgkin's Disease
4386:(11): 1765–1772.
4181:(23): 1540–1545.
3929:(12): 1015–1020.
3808:(11): 1860–1861.
3763:(27): 3059–3068.
3729:www.icd10data.com
3613:978-0-7216-0040-6
3537:(12): 1928–1935.
3507:978-0-7817-5007-3
3413:(10): 1555–1561.
3332:978-1-891483-62-2
2812:978-1-4557-2865-7
2783:978-1-107-01059-8
2770:Marcus R (2013).
2756:978-92-832-0429-9
2574:(Pt 1): 319–328.
2410:978-1-4496-3141-3
1986:According to the
1899:
1898:
1356:Nodular sclerosis
1350:Hodgkin lymphomas
1286:15% of childhood
1145:Mycosis fungoides
854:differentiation,
720:hematopathologist
683:
682:
457:Immunophenotyping
450:histopathological
442:lymph-node biopsy
299:radiation therapy
280:lymph node biopsy
262:, infection with
224:, and constantly
187:
186:
140:radiation therapy
126:Lymph node biopsy
121:Diagnostic method
21:Medical condition
5687:
5570:Mental disorders
5383:
5376:
5369:
5360:
5359:
5262:
5261:
5223:
5222:
5220:
5218:
5212:
5201:
5193:
5187:
5186:
5184:
5183:
5168:
5162:
5161:
5150:
5144:
5143:
5125:
5119:
5118:
5090:
5084:
5083:
5081:
5080:
5066:
5060:
5059:
5054:
5052:
5039:. Bethesda, MD:
5028:
5022:
5021:
5016:. Archived from
5010:
5004:
5003:
4993:
4961:
4955:
4954:
4952:
4951:
4936:
4930:
4929:
4893:
4887:
4886:
4867:10.1002/pon.3141
4861:(6): 1312–1318.
4850:
4844:
4843:
4826:(9): 1034–1039.
4814:
4808:
4807:
4771:
4765:
4764:
4762:
4761:
4746:
4740:
4739:
4721:
4697:
4688:
4687:
4686:
4684:
4679:on July 31, 2012
4678:
4672:, archived from
4660:
4647:
4641:
4640:
4630:
4606:
4600:
4599:
4589:
4557:
4551:
4550:
4540:
4508:
4502:
4501:
4483:
4459:
4453:
4452:
4442:
4418:
4412:
4411:
4375:
4369:
4368:
4366:
4365:
4350:
4344:
4343:
4333:
4316:(11): CD010983.
4301:
4295:
4294:
4284:
4256:
4250:
4249:
4239:
4207:
4201:
4200:
4190:
4166:
4160:
4159:
4136:Stain Technology
4131:
4125:
4124:
4088:
4082:
4081:
4053:
4047:
4046:
4028:
4004:
3998:
3997:
3987:
3969:
3945:
3939:
3938:
3918:
3912:
3911:
3893:
3865:
3859:
3858:
3848:
3824:
3818:
3817:
3797:
3791:
3790:
3780:
3748:
3739:
3738:
3736:
3735:
3721:
3715:
3714:
3704:
3696:
3694:
3693:
3682:
3676:
3665:
3659:
3658:
3648:
3624:
3618:
3617:
3599:
3593:
3592:
3563:
3557:
3556:
3546:
3522:
3516:
3515:
3491:
3485:
3476:
3458:
3432:
3422:
3389:
3380:
3369:
3363:
3362:
3347:
3341:
3340:
3312:
3306:
3305:
3295:
3285:
3261:
3255:
3254:
3231:Modern Pathology
3226:
3220:
3219:
3183:
3177:
3176:
3166:
3148:
3124:
3118:
3116:
3110:
3102:
3100:
3099:
3093:
3087:. Archived from
3086:
3077:
3071:
3069:
3067:
3066:
3050:
3044:
3043:
3041:
3039:
3028:
3022:
3021:
2993:
2987:
2983:
2970:
2969:
2967:
2965:
2949:
2943:
2942:
2936:
2931:
2929:
2921:
2914:
2908:
2907:
2905:
2904:
2889:
2868:
2867:
2865:
2863:
2852:"About Lymphoma"
2848:
2831:
2830:
2824:
2816:
2798:
2792:
2791:
2767:
2761:
2760:
2743:
2732:
2731:
2729:
2727:
2708:
2702:
2701:
2683:
2655:
2649:
2648:
2638:
2606:
2600:
2599:
2563:
2557:
2556:
2538:
2514:
2508:
2507:
2505:
2503:
2484:
2478:
2477:
2471:
2467:
2465:
2457:
2455:
2453:
2447:
2440:
2430:
2419:
2418:
2394:
2388:
2387:
2363:
2354:
2353:
2343:
2311:
2305:
2304:
2294:
2262:
2256:
2255:
2253:
2252:
2237:
2228:
2227:
2217:
2200:(9): 2245–2255.
2185:
2176:
2175:
2173:
2171:
2152:
2119:
2118:
2116:
2114:
2095:
2021:
1969:
1963:
1957:
1951:
1945:
1939:
1933:
1927:
1921:
1915:
1833:
1832:
1805:adverse events.
1770:Hodgkin lymphoma
1756:tisagenlecleucel
1703:Watchful waiting
1680:watchful waiting
1664:Burkitt lymphoma
1621:
1609:
1596:
1520:B-cell lymphomas
1516:T-cell lymphomas
1464:Associated with
1343:Hodgkin lymphoma
1318:mediastinal mass
1179:SĂ©zary's disease
1076:CD10, surface Ig
678:
675:
642:
634:
584:Burkitt lymphoma
512:Hodgkin lymphoma
506:Hodgkin lymphoma
434:light microscopy
387:Other symptoms:
328:developing world
315:Watchful waiting
307:targeted therapy
237:Hodgkin lymphoma
202:white blood cell
148:targeted therapy
36:
24:
23:
5695:
5694:
5690:
5689:
5688:
5686:
5685:
5684:
5655:
5654:
5653:
5648:
5394:
5387:
5357:
5352:
5351:
5328:
5327:
5273:
5250:
5231:
5226:
5216:
5214:
5210:
5199:
5195:
5194:
5190:
5181:
5179:
5170:
5169:
5165:
5152:
5151:
5147:
5140:
5126:
5122:
5091:
5087:
5078:
5076:
5068:
5067:
5063:
5050:
5048:
5029:
5025:
5012:
5011:
5007:
4976:(1): CD009075.
4962:
4958:
4949:
4947:
4938:
4937:
4933:
4894:
4890:
4855:Psycho-Oncology
4851:
4847:
4815:
4811:
4772:
4768:
4759:
4757:
4748:
4747:
4743:
4698:
4691:
4682:
4680:
4676:
4665:ABIM Foundation
4658:
4648:
4644:
4607:
4603:
4572:(7): CD012556.
4558:
4554:
4523:(8): CD012643.
4509:
4505:
4460:
4456:
4419:
4415:
4376:
4372:
4363:
4361:
4351:
4347:
4302:
4298:
4267:(5): CD004269.
4257:
4253:
4222:(1): CD009768.
4208:
4204:
4167:
4163:
4132:
4128:
4089:
4085:
4054:
4050:
4005:
4001:
3946:
3942:
3919:
3915:
3866:
3862:
3839:(14): 987–994.
3825:
3821:
3802:Cancer Research
3798:
3794:
3749:
3742:
3733:
3731:
3723:
3722:
3718:
3698:
3697:
3691:
3689:
3686:"Archived copy"
3684:
3683:
3679:
3666:
3662:
3625:
3621:
3614:
3604:Hematopathology
3600:
3596:
3564:
3560:
3523:
3519:
3508:
3492:
3488:
3390:
3383:
3370:
3366:
3349:
3348:
3344:
3333:
3313:
3309:
3262:
3258:
3227:
3223:
3188:Human Pathology
3184:
3180:
3125:
3121:
3104:
3103:
3097:
3095:
3091:
3084:
3082:"Archived copy"
3080:
3078:
3074:
3064:
3062:
3053:
3051:
3047:
3037:
3035:
3030:
3029:
3025:
2994:
2990:
2984:
2973:
2963:
2961:
2950:
2946:
2934:
2932:
2923:
2922:
2916:
2915:
2911:
2902:
2900:
2891:
2890:
2871:
2861:
2859:
2850:
2849:
2834:
2818:
2817:
2813:
2799:
2795:
2784:
2768:
2764:
2757:
2745:
2744:
2735:
2725:
2723:
2710:
2709:
2705:
2656:
2652:
2607:
2603:
2564:
2560:
2515:
2511:
2501:
2499:
2486:
2485:
2481:
2469:
2468:
2459:
2458:
2451:
2449:
2445:
2438:
2432:
2431:
2422:
2411:
2395:
2391:
2384:
2364:
2357:
2312:
2308:
2263:
2259:
2250:
2248:
2239:
2238:
2231:
2186:
2179:
2169:
2167:
2154:
2153:
2122:
2112:
2110:
2097:
2096:
2071:
2067:
2062:
2056:
2044:clinical trials
2032:
2000:
1972:
1971:
1967:
1965:
1961:
1959:
1955:
1953:
1949:
1947:
1943:
1941:
1937:
1935:
1931:
1929:
1925:
1923:
1919:
1917:
1913:
1904:
1850:
1845:
1831:
1822:
1814:Palliative care
1811:
1809:Palliative care
1772:
1715:
1688:lymphadenopathy
1672:
1656:
1632:
1625:
1622:
1613:
1610:
1601:
1597:
1540:
1497:
1492:
1491:
1490:
1477:corticosteroids
1461:Post-transplant
1447:
1443:
1442:
1429:Lymphocyte-rich
1344:
1340:
1339:
1263:
1259:
1258:
1172:5-year survival
1149:SĂ©zary syndrome
1100:
1088:
1087:
955:About 50 to 70%
919:overexpressing
735:
726:
679:
673:
670:
643:
632:
545:
534:
514:
508:
480:
422:
359:Lymphadenopathy
336:
324:developed world
288:Medical imaging
276:tobacco smoking
114:tobacco smoking
22:
17:
12:
11:
5:
5693:
5683:
5682:
5677:
5672:
5667:
5650:
5649:
5647:
5646:
5641:
5636:
5631:
5626:
5621:
5616:
5611:
5606:
5601:
5596:
5595:
5594:
5584:
5579:
5578:
5577:
5567:
5562:
5557:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5517:
5512:
5511:
5510:
5500:
5495:
5494:
5493:
5488:
5483:
5478:
5473:
5468:
5463:
5458:
5453:
5448:
5443:
5433:
5428:
5426:Binge drinking
5423:
5418:
5413:
5408:
5402:
5400:
5396:
5395:
5386:
5385:
5378:
5371:
5363:
5354:
5353:
5350:
5349:
5337:
5336:
5334:
5330:
5329:
5326:
5325:
5314:
5306:
5294:
5274:
5269:
5268:
5266:
5265:Classification
5259:
5258:
5230:
5229:External links
5227:
5225:
5224:
5188:
5163:
5145:
5138:
5120:
5101:(5): 261–281.
5085:
5061:
5023:
5020:on 2013-10-10.
5005:
4956:
4931:
4904:(4): 265–273.
4888:
4845:
4809:
4766:
4741:
4712:(5): 423–435.
4706:Cancer Journal
4689:
4642:
4621:(6): 737–744.
4601:
4552:
4503:
4474:(3): 203–212.
4454:
4413:
4370:
4345:
4296:
4251:
4202:
4161:
4126:
4083:
4064:(4): 368–369.
4048:
4019:(3): 449–454.
3999:
3940:
3913:
3860:
3819:
3792:
3740:
3716:
3677:
3660:
3639:(1): 138–143.
3619:
3612:
3594:
3575:(2): 147–151.
3558:
3517:
3506:
3486:
3484:
3483:
3482:
3481:
3480:
3479:
3478:
3477:
3449:(4): 511–518.
3433:
3381:
3364:
3342:
3331:
3307:
3256:
3237:(12): 100330.
3221:
3178:
3119:
3072:
3045:
3023:
3004:(2): 127–134.
2988:
2971:
2944:
2935:|journal=
2909:
2869:
2832:
2811:
2793:
2782:
2762:
2755:
2733:
2703:
2666:(5): 595–606.
2650:
2601:
2558:
2529:(5): 937–951.
2509:
2494:. 2011-02-02.
2479:
2470:|website=
2420:
2409:
2389:
2382:
2355:
2306:
2257:
2229:
2177:
2162:. 2014-04-25.
2120:
2105:. 2014-04-23.
2068:
2066:
2063:
2058:Main article:
2055:
2052:
2040:basic research
2031:
2028:
2011:Thomas Hodgkin
2006:Thomas Hodgkin
1999:
1996:
1966:
1960:
1954:
1948:
1942:
1936:
1930:
1924:
1918:
1912:
1911:
1903:
1900:
1897:
1896:
1893:
1890:
1886:
1885:
1882:
1879:
1875:
1874:
1871:
1868:
1864:
1863:
1860:
1857:
1853:
1852:
1847:
1842:
1838:
1837:
1830:
1827:
1821:
1818:
1810:
1807:
1771:
1768:
1720:CHOP or R-CHOP
1714:
1711:
1671:
1668:
1655:
1652:
1631:
1628:
1627:
1626:
1623:
1616:
1614:
1611:
1604:
1602:
1598:
1591:
1539:
1536:
1496:
1493:
1489:
1488:
1469:
1462:
1459:
1452:
1448:
1445:
1444:
1441:
1440:
1435:
1434:
1433:
1430:
1424:
1423:
1422:
1421:
1414:
1411:
1408:
1402:
1401:
1400:
1399:
1393:
1392:
1391:
1390:
1380:
1371:
1368:
1362:
1361:
1360:
1359:
1345:
1342:
1341:
1338:
1337:
1336:
1335:
1314:
1301:
1295:
1281:
1280:
1275:
1270:
1264:
1261:
1260:
1257:
1256:
1251:
1237:
1231:
1230:
1229:
1228:
1225:
1220:
1217:
1211:
1210:
1205:
1204:
1203:
1198:
1189:
1188:
1187:
1186:
1175:
1169:
1164:
1158:
1152:
1151:
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1101:
1097:natural killer
1090:
1089:
1086:
1085:
1084:
1083:
1080:
1077:
1074:
1064:
1058:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1006:
1005:
1004:
1003:
1000:
994:
993:and surface Ig
987:
984:
978:
977:
970:
969:
968:
967:
956:
953:
948:
945:
939:
938:
933:
927:
926:
925:
924:
913:
910:
901:
890:
884:
883:
878:
872:
871:
870:
869:
866:
859:
848:
842:
841:
837:, also called
832:
831:
830:
825:
822:
817:
805:
800:
795:
785:
779:
778:
777:
776:
773:
770:
768:immunoglobulin
764:
758:
752:
751:
736:
729:
728:
727:
724:
681:
680:
657:screen readers
646:
644:
637:
631:
628:
556:lymphoid cells
544:
541:
533:
530:
510:Main article:
507:
504:
479:
478:Classification
476:
475:
474:
464:
462:Flow cytometry
459:
421:
418:
417:
416:
415:
414:
409:
404:
399:
394:
385:
384:
383:
378:
373:
362:
335:
332:
311:plasmapheresis
303:proton therapy
192:is a group of
185:
184:
183:204,700 (2015)
181:
177:
176:
173:
169:
168:
161:
155:
154:
144:proton therapy
133:
129:
128:
123:
117:
116:
99:
93:
92:
71:
65:
64:
55:
49:
48:
38:
37:
29:
28:
20:
15:
9:
6:
4:
3:
2:
5692:
5681:
5678:
5676:
5673:
5671:
5668:
5666:
5663:
5662:
5660:
5645:
5642:
5640:
5637:
5635:
5632:
5630:
5627:
5625:
5622:
5620:
5617:
5615:
5614:Schizophrenia
5612:
5610:
5607:
5605:
5602:
5600:
5597:
5593:
5590:
5589:
5588:
5585:
5583:
5580:
5576:
5573:
5572:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5509:
5506:
5505:
5504:
5501:
5499:
5496:
5492:
5489:
5487:
5484:
5482:
5479:
5477:
5474:
5472:
5469:
5467:
5464:
5462:
5459:
5457:
5454:
5452:
5449:
5447:
5444:
5442:
5439:
5438:
5437:
5434:
5432:
5429:
5427:
5424:
5422:
5419:
5417:
5414:
5412:
5409:
5407:
5404:
5403:
5401:
5397:
5392:
5384:
5379:
5377:
5372:
5370:
5365:
5364:
5361:
5348:
5344:
5343:
5339:
5338:
5335:
5331:
5324:
5320:
5319:
5315:
5312:
5311:
5307:
5304:
5303:
5299:
5295:
5293:
5289:
5285:
5284:
5280:
5276:
5275:
5272:
5267:
5263:
5257:
5253:
5248:
5244:
5243:
5238:
5233:
5232:
5209:
5205:
5198:
5192:
5177:
5173:
5167:
5159:
5155:
5149:
5141:
5139:0-7817-1502-4
5135:
5131:
5124:
5116:
5112:
5108:
5104:
5100:
5096:
5095:Blood Reviews
5089:
5075:
5071:
5065:
5058:
5046:
5042:
5038:
5034:
5027:
5019:
5015:
5009:
5001:
4997:
4992:
4987:
4983:
4979:
4975:
4971:
4967:
4960:
4945:
4941:
4935:
4927:
4923:
4919:
4915:
4911:
4907:
4903:
4899:
4892:
4884:
4880:
4876:
4872:
4868:
4864:
4860:
4856:
4849:
4841:
4837:
4833:
4829:
4825:
4821:
4813:
4805:
4801:
4797:
4793:
4789:
4785:
4781:
4777:
4770:
4755:
4751:
4745:
4737:
4733:
4729:
4725:
4720:
4715:
4711:
4707:
4703:
4696:
4694:
4675:
4671:
4667:
4666:
4657:
4653:
4646:
4638:
4634:
4629:
4624:
4620:
4616:
4612:
4605:
4597:
4593:
4588:
4583:
4579:
4575:
4571:
4567:
4563:
4556:
4548:
4544:
4539:
4534:
4530:
4526:
4522:
4518:
4514:
4507:
4499:
4495:
4491:
4487:
4482:
4477:
4473:
4469:
4465:
4458:
4450:
4446:
4441:
4436:
4432:
4428:
4424:
4417:
4409:
4405:
4401:
4397:
4393:
4389:
4385:
4381:
4374:
4360:
4356:
4349:
4341:
4337:
4332:
4327:
4323:
4319:
4315:
4311:
4307:
4300:
4292:
4288:
4283:
4278:
4274:
4270:
4266:
4262:
4255:
4247:
4243:
4238:
4233:
4229:
4225:
4221:
4217:
4213:
4206:
4198:
4194:
4189:
4184:
4180:
4176:
4172:
4165:
4157:
4153:
4149:
4145:
4141:
4137:
4130:
4122:
4118:
4114:
4110:
4106:
4102:
4098:
4094:
4087:
4079:
4075:
4071:
4067:
4063:
4059:
4052:
4044:
4040:
4036:
4032:
4027:
4022:
4018:
4014:
4010:
4003:
3995:
3991:
3986:
3981:
3977:
3973:
3968:
3963:
3960:(9): e45937.
3959:
3955:
3951:
3944:
3936:
3932:
3928:
3924:
3917:
3909:
3905:
3901:
3897:
3892:
3887:
3883:
3879:
3875:
3871:
3864:
3856:
3852:
3847:
3842:
3838:
3834:
3830:
3823:
3815:
3811:
3807:
3803:
3796:
3788:
3784:
3779:
3774:
3770:
3766:
3762:
3758:
3754:
3747:
3745:
3730:
3726:
3720:
3712:
3708:
3702:
3687:
3681:
3675:
3671:
3670:
3664:
3656:
3652:
3647:
3642:
3638:
3634:
3630:
3623:
3615:
3609:
3605:
3598:
3590:
3586:
3582:
3578:
3574:
3570:
3562:
3554:
3550:
3545:
3540:
3536:
3532:
3528:
3521:
3513:
3509:
3503:
3499:
3498:
3490:
3474:
3470:
3466:
3462:
3457:
3452:
3448:
3444:
3440:
3434:
3430:
3426:
3421:
3416:
3412:
3408:
3404:
3398:
3397:
3396:
3395:
3394:
3393:
3392:
3391:
3388:
3386:
3379:
3375:
3374:
3368:
3360:
3356:
3352:
3346:
3338:
3334:
3328:
3324:
3323:
3318:
3311:
3303:
3299:
3294:
3289:
3284:
3279:
3276:(9): e45937.
3275:
3271:
3267:
3260:
3252:
3248:
3244:
3240:
3236:
3232:
3225:
3217:
3213:
3209:
3205:
3201:
3197:
3193:
3189:
3182:
3174:
3170:
3165:
3160:
3156:
3152:
3147:
3142:
3139:(9): e45937.
3138:
3134:
3130:
3123:
3114:
3108:
3094:on 2014-01-24
3090:
3083:
3076:
3060:
3056:
3049:
3033:
3027:
3019:
3015:
3011:
3007:
3003:
2999:
2992:
2982:
2980:
2978:
2976:
2959:
2955:
2948:
2940:
2927:
2920:. 2019-11-09.
2919:
2913:
2898:
2894:
2888:
2886:
2884:
2882:
2880:
2878:
2876:
2874:
2857:
2853:
2847:
2845:
2843:
2841:
2839:
2837:
2828:
2822:
2814:
2808:
2804:
2797:
2789:
2785:
2779:
2775:
2774:
2766:
2758:
2752:
2748:
2742:
2740:
2738:
2721:
2717:
2713:
2707:
2699:
2695:
2691:
2687:
2682:
2677:
2673:
2669:
2665:
2661:
2654:
2646:
2642:
2637:
2632:
2628:
2624:
2621:(45): e1729.
2620:
2616:
2612:
2605:
2597:
2593:
2589:
2585:
2581:
2577:
2573:
2569:
2562:
2554:
2550:
2546:
2542:
2537:
2532:
2528:
2524:
2520:
2513:
2497:
2493:
2489:
2483:
2475:
2463:
2444:
2437:
2436:
2429:
2427:
2425:
2416:
2412:
2406:
2402:
2401:
2393:
2385:
2383:0-7216-6254-4
2379:
2375:
2371:
2370:
2362:
2360:
2351:
2347:
2342:
2337:
2333:
2329:
2325:
2321:
2317:
2310:
2302:
2298:
2293:
2288:
2284:
2280:
2276:
2272:
2268:
2261:
2246:
2242:
2236:
2234:
2225:
2221:
2216:
2211:
2207:
2203:
2199:
2195:
2191:
2184:
2182:
2165:
2161:
2157:
2151:
2149:
2147:
2145:
2143:
2141:
2139:
2137:
2135:
2133:
2131:
2129:
2127:
2125:
2108:
2104:
2100:
2094:
2092:
2090:
2088:
2086:
2084:
2082:
2080:
2078:
2076:
2074:
2069:
2061:
2054:Other animals
2051:
2047:
2045:
2041:
2037:
2027:
2025:
2020:
2014:
2012:
2004:
1995:
1991:
1989:
1984:
1981:
1979:
1970: 122–184
1908:
1887:
1876:
1865:
1854:
1851:of cases (%)
1846:survival (%)
1839:
1834:
1826:
1817:
1815:
1806:
1803:
1798:
1795:
1790:
1788:
1784:
1780:
1775:
1767:
1765:
1761:
1757:
1753:
1749:
1745:
1740:
1737:
1733:
1729:
1724:
1721:
1710:
1708:
1704:
1700:
1695:
1693:
1689:
1683:
1681:
1677:
1667:
1665:
1661:
1651:
1649:
1645:
1641:
1637:
1620:
1615:
1608:
1603:
1595:
1590:
1589:
1588:
1586:
1583:Age and poor
1581:
1579:
1575:
1571:
1567:
1565:
1560:
1555:
1553:
1544:
1535:
1533:
1529:
1523:
1521:
1517:
1513:
1509:
1505:
1500:
1486:
1482:
1478:
1473:
1470:
1467:
1463:
1460:
1457:
1453:
1450:
1449:
1439:
1436:
1431:
1428:
1427:
1426:
1425:
1419:
1415:
1412:
1409:
1406:
1405:
1404:
1403:
1397:
1396:
1395:
1394:
1389:
1385:
1381:
1379:
1375:
1372:
1369:
1366:
1365:
1364:
1363:
1357:
1354:
1353:
1351:
1347:
1346:
1333:
1329:
1328:
1323:
1319:
1315:
1313:
1309:
1305:
1302:
1299:
1296:
1293:
1289:
1285:
1284:
1283:
1282:
1279:
1276:
1274:
1271:
1269:
1266:
1265:
1255:
1252:
1249:
1245:
1241:
1238:
1236:
1233:
1232:
1226:
1224:
1221:
1218:
1215:
1214:
1213:
1212:
1209:
1206:
1202:
1199:
1197:
1194:
1193:
1191:
1190:
1184:
1180:
1176:
1173:
1170:
1168:
1165:
1163:
1159:
1156:
1155:
1154:
1153:
1150:
1146:
1143:
1141:
1138:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1102:
1098:
1094:
1081:
1078:
1075:
1073:
1069:
1065:
1062:
1061:
1060:
1059:
1056:
1053:
1051:
1048:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1007:
1001:
998:
995:
992:
988:
985:
982:
981:
980:
979:
975:
972:
971:
965:
961:
957:
954:
952:
949:
946:
943:
942:
941:
940:
937:
934:
932:
929:
928:
922:
918:
917:translocation
914:
911:
909:
905:
902:
899:
895:
891:
888:
887:
886:
885:
882:
879:
877:
874:
873:
867:
864:
860:
857:
853:
849:
846:
845:
844:
843:
840:
839:MALT lymphoma
836:
833:
829:
826:
823:
821:
818:
815:
812:
811:
809:
806:
804:
801:
799:
796:
793:
789:
786:
784:
781:
780:
774:
771:
769:
766:CD5, surface
765:
763:
759:
756:
755:
754:
753:
750:
747:
746:
740:
733:
723:
721:
717:
713:
709:
705:
700:
697:
693:
689:
677:
668:
664:
662:
658:
653:
651:
650:accessibility
645:
641:
636:
635:
627:
625:
621:
617:
613:
609:
605:
601:
597:
593:
589:
585:
581:
577:
573:
569:
565:
561:
557:
553:
549:
540:
538:
529:
527:
523:
519:
513:
503:
501:
497:
492:
484:
472:
471:hybridization
470:
467:Fluorescence
465:
463:
460:
458:
455:
454:
453:
451:
447:
443:
435:
431:
430:H&E stain
426:
413:
410:
408:
405:
403:
400:
398:
395:
392:
389:
388:
386:
382:
379:
377:
374:
372:
369:
368:
366:
363:
360:
357:
356:
355:
348:
340:
331:
329:
325:
320:
316:
312:
308:
304:
300:
296:
291:
289:
285:
281:
277:
273:
269:
265:
261:
257:
253:
248:
246:
242:
238:
234:
229:
227:
226:feeling tired
223:
219:
215:
211:
207:
203:
199:
195:
191:
182:
178:
174:
170:
166:
162:
160:
156:
153:
149:
145:
141:
137:
134:
130:
127:
124:
122:
118:
115:
111:
107:
103:
100:
98:
94:
91:
90:feeling tired
87:
83:
79:
75:
72:
70:
66:
63:
59:
56:
54:
50:
47:
43:
39:
35:
30:
25:
19:
5644:Tuberculosis
5555:Malnutrition
5399:Health topic
5391:epidemiology
5340:
5316:
5308:
5296:
5277:
5240:
5215:. Retrieved
5208:the original
5203:
5191:
5180:. Retrieved
5166:
5157:
5148:
5129:
5123:
5098:
5094:
5088:
5077:. Retrieved
5073:
5064:
5056:
5049:. Retrieved
5036:
5026:
5018:the original
5008:
4973:
4969:
4959:
4948:. Retrieved
4934:
4901:
4897:
4891:
4858:
4854:
4848:
4823:
4819:
4812:
4782:(2): 71–75.
4779:
4775:
4769:
4758:. Retrieved
4744:
4709:
4705:
4681:, retrieved
4674:the original
4662:
4645:
4618:
4614:
4604:
4569:
4565:
4555:
4520:
4516:
4506:
4471:
4467:
4457:
4430:
4426:
4416:
4383:
4379:
4373:
4362:. Retrieved
4358:
4348:
4313:
4309:
4299:
4264:
4254:
4219:
4215:
4205:
4178:
4174:
4164:
4142:(1): 23–26.
4139:
4135:
4129:
4096:
4092:
4086:
4061:
4057:
4051:
4016:
4012:
4002:
3957:
3953:
3943:
3926:
3922:
3916:
3884:(1): 75–85.
3881:
3877:
3863:
3836:
3832:
3822:
3805:
3801:
3795:
3760:
3756:
3732:. Retrieved
3728:
3719:
3690:. Retrieved
3680:
3667:
3663:
3636:
3632:
3622:
3603:
3597:
3572:
3568:
3561:
3534:
3530:
3520:
3496:
3489:
3446:
3442:
3410:
3406:
3371:
3367:
3354:
3345:
3321:
3310:
3273:
3269:
3259:
3234:
3230:
3224:
3191:
3187:
3181:
3136:
3132:
3122:
3096:. Retrieved
3089:the original
3075:
3063:. Retrieved
3048:
3036:. Retrieved
3034:. 2015-05-14
3026:
3001:
2997:
2991:
2962:. Retrieved
2947:
2926:cite journal
2912:
2901:. Retrieved
2860:. Retrieved
2802:
2796:
2772:
2765:
2746:
2724:. Retrieved
2715:
2706:
2681:11573/865541
2663:
2659:
2653:
2618:
2614:
2604:
2571:
2567:
2561:
2526:
2522:
2512:
2500:. Retrieved
2491:
2482:
2450:. Retrieved
2434:
2399:
2392:
2368:
2323:
2319:
2309:
2274:
2270:
2260:
2249:. Retrieved
2197:
2193:
2168:. Retrieved
2159:
2111:. Retrieved
2102:
2048:
2033:
2023:
2015:
2009:
1992:
1985:
1982:
1975:
1964: 89–121
1902:Epidemiology
1823:
1812:
1799:
1791:
1776:
1773:
1741:
1725:
1716:
1696:
1684:
1673:
1657:
1633:
1582:
1568:
1556:
1549:
1524:
1501:
1498:
1485:chemotherapy
1481:radiotherapy
1466:methotrexate
1325:
1298:Lymphoblasts
1248:ALK-negative
1244:ALK-positive
912:About 72–77%
898:centroblasts
865:, surface Ig
820:Plasmacytoma
701:
684:
671:
655:
647:
552:premalignant
546:
535:
522:pathological
520:and several
515:
493:
489:
468:
439:
376:Night sweats
353:
295:chemotherapy
292:
249:
230:
216:, drenching
189:
188:
136:Chemotherapy
97:Risk factors
44:replacing a
18:
5535:Hepatitis D
5530:Hepatitis C
5498:Chikungunya
5342:MedlinePlus
5313:: 9590–9999
5235:‹ The
4433:: 497–506.
4099:: 532–541.
2986:Manuscript.
2964:22 December
2952:Mallick I.
2862:22 December
1958: 58–88
1952: 43–57
1946: 35–42
1940: 29–34
1934: 23–28
1928: 19–22
1922: 14–18
1384:mediastinum
1290:and 90% of
894:centrocytes
852:plasma cell
810:neoplasms:
808:Plasma cell
718:(usually a
716:pathologist
696:cytogenetic
381:Weight loss
270:, and some
200:(a type of
198:lymphocytes
5675:Hematology
5659:Categories
5619:Snakebites
5515:Depression
5461:esophageal
5456:colorectal
5182:2012-10-30
5079:2024-04-22
5051:3 November
4950:2014-08-21
4760:2014-08-21
4683:August 14,
4364:2021-02-09
3734:2022-02-02
3692:2005-11-07
3098:2013-08-05
3065:2013-08-05
2903:2012-12-01
2488:"Lymphoma"
2251:2012-08-26
2065:References
1916: 0–13
1849:Percentage
1787:Stanford V
1713:High-grade
1413:CD15, CD30
1348:Classical
1332:adolescent
923:, indolent
906:, surface
688:phenotypic
446:lymph node
365:B symptoms
272:pesticides
58:Hematology
46:lymph node
5604:Pneumonia
5592:childhood
3976:2168-8184
3870:Pinkus GS
3674:eMedicine
3378:eMedicine
3194:: 18–41.
3155:2168-8184
3038:2 October
2821:cite book
2472:ignored (
2462:cite book
1829:Prognosis
1802:Nivolumab
1699:rituximab
1692:incurable
1670:Low-grade
1654:Treatment
1564:diaphragm
1072:apoptosis
964:cyclin D1
790:(such as
734:neoplasms
712:prognosis
692:molecular
674:July 2024
667:talk page
518:prognosis
420:Diagnosis
326:than the
241:leukemias
206:cancerous
172:Frequency
167:85% (USA)
159:Prognosis
132:Treatment
53:Specialty
5665:Lymphoma
5634:Syphilis
5545:HIV/AIDS
5503:Dementia
5476:prostate
5471:lymphoma
5451:cervical
5421:Bed bugs
5252:Lymphoma
5237:template
5176:Archived
5115:18456377
5045:Archived
5000:30702150
4944:Archived
4926:20112284
4918:19151797
4883:31552330
4875:22836818
4840:23901834
4796:20078405
4754:Archived
4736:39881122
4728:20890138
4637:17531914
4596:30001476
4547:31930780
4498:10038896
4490:21774708
4449:20008235
4408:11004437
4400:19883306
4340:26576687
4291:22592695
4246:30697701
4121:12185761
4113:20008238
4078:24602759
4043:25207677
4035:18467294
3994:37900448
3985:10601349
3935:20017283
3923:Oncology
3908:52272766
3900:30212873
3787:25113753
3701:cite web
3655:14744745
3589:10435806
3553:16284057
3512:Archived
3473:32350562
3465:19075279
3429:14504058
3359:Archived
3337:Archived
3302:37900448
3293:10601349
3251:37716508
3216:47010934
3208:29885408
3173:37900448
3164:10601349
3117:), pg 4.
3107:cite web
3059:Archived
3018:20696592
2958:Archived
2897:Archived
2856:Archived
2788:Archived
2720:Archived
2698:17430078
2690:27076059
2645:26559248
2615:Medicine
2596:28810201
2545:19357394
2496:Archived
2443:Archived
2441:. 2013.
2415:Archived
2350:27733281
2301:27733282
2245:Archived
2224:23788758
2164:Archived
2107:Archived
2030:Research
1676:indolent
1600:H&E)
1574:PET scan
1183:erythema
960:GI tract
568:NK cells
500:meninges
260:HIV/AIDS
190:Lymphoma
163:Average
110:HIV/AIDS
69:Symptoms
62:oncology
27:Lymphoma
5624:Suicide
5587:Obesity
5560:Measles
5550:Leprosy
5491:ovarian
5486:stomach
5441:bladder
5389:Global
5323:D008223
5305:: 202.8
5239:below (
4991:6354325
4804:8355159
4587:6513229
4538:6984446
4331:4717525
4282:4338578
4237:6353308
4197:7477169
4156:4550425
3855:8141877
3814:5121694
3778:4979083
2726:18 June
2636:4912242
2576:Bibcode
2553:3101472
2502:13 June
2452:20 June
2341:5388903
2292:5055577
2215:3755332
2170:20 June
2113:20 June
1998:History
1783:BEACOPP
1707:anxiety
1570:CT scan
1538:Staging
1468:therapy
1181:, skin
1091:Mature
762:effaced
730:Mature
564:T cells
560:B cells
558:(i.e.,
473:testing
469:in situ
412:Itching
402:Fatigue
222:itching
152:surgery
86:itching
5629:Stroke
5540:Herpes
5446:breast
5436:Cancer
5416:Autism
5406:Asthma
5347:000580
5256:Curlie
5242:Curlie
5217:19 May
5154:"-oma"
5136:
5113:
4998:
4988:
4924:
4916:
4881:
4873:
4838:
4802:
4794:
4734:
4726:
4635:
4594:
4584:
4545:
4535:
4496:
4488:
4447:
4406:
4398:
4338:
4328:
4289:
4279:
4244:
4234:
4195:
4154:
4119:
4111:
4076:
4041:
4033:
3992:
3982:
3974:
3954:Cureus
3933:
3906:
3898:
3853:
3812:
3785:
3775:
3653:
3610:
3587:
3551:
3504:
3471:
3463:
3427:
3329:
3300:
3290:
3270:Cureus
3249:
3214:
3206:
3171:
3161:
3153:
3133:Cureus
3016:
2809:
2780:
2753:
2696:
2688:
2643:
2633:
2594:
2551:
2543:
2407:
2380:
2348:
2338:
2320:Lancet
2299:
2289:
2271:Lancet
2222:
2212:
2019:lympha
1968:
1962:
1956:
1950:
1944:
1938:
1932:
1926:
1920:
1914:
1552:staged
1532:ICD-10
1483:, and
1334:males.
1327:NOTCH1
1322:thymus
1093:T cell
856:homing
732:B cell
661:hidden
622:; and
570:, and
391:Anemia
218:sweats
180:Deaths
82:sweats
5575:child
5466:liver
5310:ICD-O
5211:(PDF)
5200:(PDF)
4922:S2CID
4879:S2CID
4800:S2CID
4732:S2CID
4677:(PDF)
4659:(PDF)
4494:S2CID
4404:S2CID
4117:S2CID
4039:S2CID
3904:S2CID
3469:S2CID
3212:S2CID
3092:(PDF)
3085:(PDF)
2694:S2CID
2549:S2CID
2523:Blood
2446:(PDF)
2439:(PDF)
1892:68.6
1881:62.7
1870:78.3
1859:82.3
1762:(for
1742:Four
1660:grade
1528:ICD-O
1250:types
921:Bcl-2
861:CD5,
694:, or
371:Fever
214:fever
78:fever
5481:skin
5318:MeSH
5302:9-CM
5219:2010
5134:ISBN
5111:PMID
5053:2009
4996:PMID
4914:PMID
4871:PMID
4836:PMID
4792:PMID
4724:PMID
4685:2012
4633:PMID
4592:PMID
4570:2018
4543:PMID
4486:PMID
4445:PMID
4431:2009
4396:PMID
4336:PMID
4314:2015
4287:PMID
4242:PMID
4193:PMID
4152:PMID
4109:PMID
4097:2009
4074:PMID
4031:PMID
3990:PMID
3972:ISSN
3931:PMID
3896:PMID
3851:PMID
3810:PMID
3783:PMID
3711:link
3707:link
3651:PMID
3608:ISBN
3585:PMID
3549:PMID
3502:ISBN
3461:PMID
3425:PMID
3327:ISBN
3298:PMID
3247:PMID
3204:PMID
3169:PMID
3151:ISSN
3113:link
3040:2017
3014:PMID
2966:2012
2939:help
2864:2012
2827:link
2807:ISBN
2778:ISBN
2751:ISBN
2728:2014
2686:PMID
2641:PMID
2592:PMID
2541:PMID
2504:2014
2474:help
2454:2014
2405:ISBN
2378:ISBN
2374:1038
2346:PMID
2297:PMID
2220:PMID
2172:2014
2115:2014
2038:and
2024:-oma
1785:and
1779:ABVD
1638:and
1562:the
1557:The
1518:and
1502:The
1378:CD30
1374:CD15
1246:and
1095:and
991:CD10
904:CD10
863:CD10
648:The
60:and
5298:ICD
5292:C96
5288:C81
5279:ICD
5254:at
5103:doi
4986:PMC
4978:doi
4906:doi
4863:doi
4828:doi
4784:doi
4780:192
4714:doi
4623:doi
4582:PMC
4574:doi
4533:PMC
4525:doi
4476:doi
4472:365
4435:doi
4388:doi
4326:PMC
4318:doi
4277:PMC
4269:doi
4232:PMC
4224:doi
4183:doi
4179:333
4144:doi
4101:doi
4066:doi
4021:doi
3980:PMC
3962:doi
3886:doi
3882:151
3841:doi
3837:329
3773:PMC
3765:doi
3672:at
3641:doi
3577:doi
3539:doi
3451:doi
3415:doi
3376:at
3288:PMC
3278:doi
3239:doi
3196:doi
3159:PMC
3141:doi
3006:doi
2716:NCI
2676:hdl
2668:doi
2631:PMC
2623:doi
2584:doi
2572:231
2531:doi
2527:114
2492:NCI
2336:PMC
2328:doi
2324:388
2287:PMC
2279:doi
2275:388
2210:PMC
2202:doi
1884:47
1873:19
1862:26
1572:or
1456:HIV
1386:or
1312:CD7
1308:CD2
1304:TdT
1223:CD3
1174:75%
1167:CD4
999:60%
951:CD5
722:).
669:.
5661::
5345::
5321::
5286::
5283:10
5202:.
5174:.
5156:.
5109:.
5099:22
5097:.
5072:.
5055:.
5043:.
5035:.
4994:.
4984:.
4972:.
4968:.
4942:.
4920:.
4912:.
4902:43
4900:.
4877:.
4869:.
4859:22
4857:.
4834:.
4824:16
4822:.
4798:.
4790:.
4778:.
4752:.
4730:.
4722:.
4710:16
4708:.
4704:.
4692:^
4668:,
4661:,
4654:,
4631:.
4619:33
4617:.
4613:.
4590:.
4580:.
4568:.
4564:.
4541:.
4531:.
4519:.
4515:.
4492:.
4484:.
4470:.
4466:.
4443:.
4429:.
4425:.
4402:.
4394:.
4384:50
4382:.
4357:.
4334:.
4324:.
4312:.
4308:.
4285:.
4275:.
4263:.
4240:.
4230:.
4218:.
4214:.
4191:.
4177:.
4173:.
4150:.
4140:47
4138:.
4115:.
4107:.
4095:.
4072:.
4062:15
4060:.
4037:.
4029:.
4017:35
4015:.
4011:.
3988:.
3978:.
3970:.
3958:15
3956:.
3952:.
3927:23
3925:.
3902:.
3894:.
3880:.
3876:.
3849:.
3835:.
3831:.
3806:31
3804:.
3781:.
3771:.
3761:32
3759:.
3755:.
3743:^
3727:.
3703:}}
3699:{{
3649:.
3637:13
3635:.
3631:.
3583:.
3573:51
3571:.
3547:.
3535:16
3533:.
3529:.
3510:.
3467:.
3459:.
3447:27
3445:.
3441:.
3423:.
3411:14
3409:.
3405:.
3384:^
3357:.
3353:.
3335:.
3296:.
3286:.
3274:15
3272:.
3268:.
3245:.
3235:36
3233:.
3210:.
3202:.
3192:79
3190:.
3167:.
3157:.
3149:.
3137:15
3135:.
3131:.
3109:}}
3105:{{
3057:.
3012:.
3002:79
3000:.
2974:^
2930::
2928:}}
2924:{{
2872:^
2835:^
2823:}}
2819:{{
2786:.
2736:^
2718:.
2714:.
2692:.
2684:.
2674:.
2664:27
2662:.
2639:.
2629:.
2619:94
2617:.
2613:.
2590:.
2582:.
2570:.
2547:.
2539:.
2525:.
2521:.
2490:.
2466::
2464:}}
2460:{{
2423:^
2413:.
2376:.
2358:^
2344:.
2334:.
2322:.
2318:.
2295:.
2285:.
2273:.
2269:.
2232:^
2218:.
2208:.
2198:24
2196:.
2192:.
2180:^
2158:.
2123:^
2101:.
2072:^
1895:8
1754:,
1694:.
1479:,
1376:,
1352::
1310:,
1306:,
1242::
908:Ig
690:,
626:.
618:;
614:;
610:;
606:;
602:;
598:;
594:;
590:;
586:;
566:,
562:,
528:.
330:.
305:,
301:,
297:,
266:,
258:,
247:.
212:,
150:,
146:,
142:,
138:,
112:,
108:,
104:,
88:,
80:,
76:,
5382:e
5375:t
5368:v
5300:-
5290:–
5281:-
5271:D
5221:.
5185:.
5160:.
5142:.
5117:.
5105::
5082:.
5002:.
4980::
4974:1
4953:.
4928:.
4908::
4885:.
4865::
4842:.
4830::
4806:.
4786::
4763:.
4738:.
4716::
4639:.
4625::
4598:.
4576::
4549:.
4527::
4521:1
4500:.
4478::
4451:.
4437::
4410:.
4390::
4367:.
4342:.
4320::
4293:.
4271::
4248:.
4226::
4220:1
4199:.
4185::
4158:.
4146::
4123:.
4103::
4080:.
4068::
4045:.
4023::
3996:.
3964::
3937:.
3910:.
3888::
3857:.
3843::
3816:.
3789:.
3767::
3737:.
3713:)
3695:.
3657:.
3643::
3616:.
3591:.
3579::
3555:.
3541::
3475:.
3453::
3431:.
3417::
3304:.
3280::
3253:.
3241::
3218:.
3198::
3175:.
3143::
3115:)
3101:.
3068:.
3042:.
3020:.
3008::
2968:.
2941:)
2937:(
2906:.
2866:.
2829:)
2815:.
2759:.
2730:.
2700:.
2678::
2670::
2647:.
2625::
2598:.
2586::
2578::
2555:.
2533::
2506:.
2476:)
2456:.
2386:.
2352:.
2330::
2303:.
2281::
2254:.
2226:.
2204::
2174:.
2117:.
1458:)
1294:.
1147:/
794:)
676:)
672:(
663:.
436:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
