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Perisinusoidal space

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68: 40: 257:). The excess extracellular matrix may be cleared as the causative insult subsides and the liver parenchyma regenerates with appropriate macrostructure if injury is limited to the center of the liver lobules; when injury affects entire liver lobules, fibrous septa form, impeding structural restoration and promoting nodule formation ( 171:
components from the sinusoids to be absorbed by the hepatocytes. Fenestration and discontinuity of the endothelium facilitates this transport. The perisinusoidal space also contains
396: 424: 387: โ€“ Histology Learning System at Boston University - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse" 229:(which may arise due to various insults) promotes proliferation of hepatic fibroblasts as well as transformation of stellate cells into 417: 374: 393: โ€“ Histology Learning System at Boston University - "Liver, Gall Bladder, and Pancreas: liver; sinusoids and Kupffer cells" 348: 410: 547: 286: 122: 17: 697: 434: 492: 115: 713: 733: 378: 110: 402: 591: 576: 470: 253:), and impaired substance exchange between sinusoidal blood and hepatocytes (which may result in 756: 485: 450: 276: 537: 480: 254: 172: 390: 384: 249:) which results in increased resistance to blood flow in the sinusoids (which may result in 184: 8: 608: 250: 57: 761: 603: 460: 399:- Comparative Organology at University of California, Davis - "Mammal, liver (EM, Low)" 728: 723: 641: 598: 354: 344: 319: 282: 693: 688: 683: 678: 636: 631: 586: 581: 519: 507: 311: 246: 708: 315: 651: 502: 475: 156: 750: 559: 524: 465: 358: 277:
Robbins, Stanley L.; Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker (1999).
230: 198:, leading to decreased uptake by hepatocytes of nutrients and wastes such as 195: 542: 514: 455: 338: 323: 242: 238: 226: 209: 168: 160: 626: 618: 164: 128: 532: 152: 53: 568: 258: 206: 199: 188: 67: 49: 667: 432: 234: 167:
of hepatocytes extend into this space, allowing proteins and other
48:
liver with fenestrated endothelial cells. Fenestrae are approx 100
233:. These then secrete extracellular matrix components (various 442: 148: 98: 86: 39: 180: 45: 302:Haubrich WS (2004). "Disse of the space of Disse". 27:Location in liver between hepatocyte and sinusoid 748: 56:. Scanning electron micrograph by Robin Fraser, 336: 418: 397:Anatomy photo: digestive/mammal/liver5/liver7 301: 295: 270: 205:The Space of Disse is named for the German 425: 411: 337:Silbernagl, Stefan; Lang, Florian (2009). 66: 38: 14: 749: 245:) into the perisinusoidal space (i.e. 406: 343:(2nd ed.). Thieme. p. 186. 52:diameter, and the sinusoidal width 5 279:Robbins pathologic basis of disease 225:Hepatic cell injury and consequent 24: 215: 25: 773: 548:Liver sinusoidal endothelial cell 368: 194:This space may be obliterated in 435:liver, pancreas and biliary tree 123:Anatomical terms of microanatomy 340:Color Atlas of Pathophysiology 330: 13: 1: 264: 316:10.1053/j.gastro.2004.10.021 7: 220: 10: 778: 493:Fibrous capsule of Glisson 281:. Philadelphia: Saunders. 666: 617: 567: 558: 441: 391:Histology image: 15204loa 385:Histology image: 22103loa 121: 109: 97: 92: 82: 77: 65: 37: 32: 577:Intrahepatic bile ducts 147:) is a location in the 104:spatium perisinusoideum 375:UIUC Histology Subject 173:hepatic stellate cells 538:Hepatic stellate cell 255:chronic liver failure 227:inflammatory response 72:Basic liver structure 498:Perisinusoidal space 185:fat soluble vitamins 141:perisinusoidal space 33:Perisinusoidal space 609:Common hepatic duct 251:portal hypertension 58:University of Otago 604:Right hepatic duct 461:Ligamentum venosum 159:. It contains the 116:H3.04.05.0.00012 744: 743: 729:Centroacinar cell 724:Pancreatic islets 662: 661: 642:Sphincter of Oddi 599:Left hepatic duct 350:978-3-13-116552-7 137: 136: 132: 16:(Redirected from 769: 698:Uncinate process 637:Ampulla of Vater 632:Common bile duct 587:Canals of Hering 582:Bile canaliculus 565: 564: 520:Lobules of liver 508:Periportal space 427: 420: 413: 404: 403: 363: 362: 334: 328: 327: 304:Gastroenterology 299: 293: 292: 274: 247:hepatic fibrosis 129:edit on Wikidata 126: 70: 42: 30: 29: 21: 777: 776: 772: 771: 770: 768: 767: 766: 747: 746: 745: 740: 658: 613: 554: 437: 433:Anatomy of the 431: 371: 366: 351: 335: 331: 300: 296: 289: 275: 271: 267: 223: 218: 216:Pathophysiology 179:), which store 175:(also known as 133: 73: 61: 28: 23: 22: 15: 12: 11: 5: 775: 765: 764: 759: 742: 741: 739: 738: 737: 736: 731: 726: 718: 717: 716: 711: 703: 702: 701: 691: 686: 681: 672: 670: 664: 663: 660: 659: 657: 656: 655: 654: 652:Cholecystocyte 646: 645: 644: 634: 629: 623: 621: 615: 614: 612: 611: 606: 601: 596: 595: 594: 589: 584: 573: 571: 562: 556: 555: 553: 552: 551: 550: 545: 540: 535: 527: 522: 517: 512: 511: 510: 503:Liver sinusoid 500: 495: 490: 489: 488: 483: 476:Lobes of liver 473: 471:Round ligament 468: 463: 458: 453: 447: 445: 439: 438: 430: 429: 422: 415: 407: 401: 400: 394: 388: 382: 370: 369:External links 367: 365: 364: 349: 329: 294: 287: 268: 266: 263: 231:myofibroblasts 222: 219: 217: 214: 145:space of Disse 135: 134: 125: 119: 118: 113: 107: 106: 101: 95: 94: 90: 89: 84: 80: 79: 75: 74: 71: 63: 62: 44:Sinusoid of a 43: 35: 34: 26: 18:Space of Disse 9: 6: 4: 3: 2: 774: 763: 760: 758: 757:Liver anatomy 755: 754: 752: 735: 734:Stellate cell 732: 730: 727: 725: 722: 721: 720:Microanatomy 719: 715: 712: 710: 707: 706: 704: 699: 695: 692: 690: 687: 685: 682: 680: 677: 676: 674: 673: 671: 669: 665: 653: 650: 649: 647: 643: 640: 639: 638: 635: 633: 630: 628: 625: 624: 622: 620: 616: 610: 607: 605: 602: 600: 597: 593: 590: 588: 585: 583: 580: 579: 578: 575: 574: 572: 570: 566: 563: 561: 560:Biliary tract 557: 549: 546: 544: 541: 539: 536: 534: 531: 530: 529:Microanatomy 528: 526: 525:Liver segment 523: 521: 518: 516: 513: 509: 506: 505: 504: 501: 499: 496: 494: 491: 487: 484: 482: 479: 478: 477: 474: 472: 469: 467: 466:Porta hepatis 464: 462: 459: 457: 454: 452: 449: 448: 446: 444: 440: 436: 428: 423: 421: 416: 414: 409: 408: 405: 398: 395: 392: 389: 386: 383: 381: 380: 376: 373: 372: 360: 356: 352: 346: 342: 341: 333: 325: 321: 317: 313: 309: 305: 298: 290: 288:0-7216-7335-X 284: 280: 273: 269: 262: 260: 256: 252: 248: 244: 243:glycoproteins 240: 239:proteoglycans 236: 232: 228: 213: 212:(1852โ€“1912). 211: 208: 203: 201: 197: 196:liver disease 192: 190: 186: 182: 178: 174: 170: 166: 162: 158: 154: 150: 146: 142: 130: 124: 120: 117: 114: 112: 108: 105: 102: 100: 96: 91: 88: 85: 81: 76: 69: 64: 59: 55: 51: 47: 41: 36: 31: 19: 592:Interlobular 543:Kupffer cell 515:Portal triad 497: 456:Cantlie line 377: 339: 332: 307: 303: 297: 278: 272: 224: 210:Joseph Disse 204: 193: 176: 161:blood plasma 144: 140: 138: 103: 627:Cystic duct 619:Gallbladder 310:(6): 1684. 261:) instead. 187:including 93:Identifiers 751:Categories 569:Bile ducts 533:Hepatocyte 265:References 165:Microvilli 153:hepatocyte 151:between a 762:Histology 714:accessory 451:Bare area 359:439472713 259:cirrhosis 235:collagens 207:anatomist 200:bilirubin 189:vitamin A 177:Ito cells 668:Pancreas 486:Quadrate 324:15578505 221:Fibrosis 157:sinusoid 83:Location 481:Caudate 78:Details 705:Ducts 675:Gross 648:Cells 357:  347:  322:  285:  241:, and 169:plasma 155:and a 443:Liver 149:liver 127:[ 99:Latin 87:Liver 709:main 694:Head 689:Neck 684:Body 679:Tail 379:1317 355:OCLC 345:ISBN 320:PMID 283:ISBN 143:(or 139:The 312:doi 308:127 191:). 183:or 181:fat 163:. 46:rat 753:: 353:. 318:. 306:. 237:, 202:. 111:TH 54:ยตm 50:nm 700:) 696:( 426:e 419:t 412:v 361:. 326:. 314:: 291:. 131:] 60:. 20:)

Index

Space of Disse

rat
nm
ยตm
University of Otago

Liver
Latin
TH
H3.04.05.0.00012
Anatomical terms of microanatomy
edit on Wikidata
liver
hepatocyte
sinusoid
blood plasma
Microvilli
plasma
hepatic stellate cells
fat
fat soluble vitamins
vitamin A
liver disease
bilirubin
anatomist
Joseph Disse
inflammatory response
myofibroblasts
collagens

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