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Scrub typhus

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282:, but the main limitation of this method is the availability of fluorescent microscopes, which are not often available in resource-poor settings where scrub typhus is endemic. Indirect immunoperoxidase, a modification of the standard IFA method, can be used with a light microscope, and the results of these tests are comparable to those from IFA. Rapid bedside kits have been described that produce a result within one hour, but the availability of these tests is severely limited by their cost. Serological methods are most reliable when a four-fold rise in antibody titre is found. If the patient is from a nonendemic area, then diagnosis can be made from a single acute serum sample. In patients from endemic areas, this is not possible because antibodies may be found in up to 18% of healthy individuals. 391: 42: 267:
often absent since the bite does not inflict pain and the mites are almost too small to be seen by the naked eye. Usually, scrub typhus is often labelled as PUO in remote endemic areas, since blood culture is often negative, yet it can be treated effectively with chloramphenicol. Where doubt exists, the diagnosis may be confirmed by a laboratory test such as
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strains is now recognized, and immunity to one strain does not confer immunity to another. Any scrub typhus vaccine should give protection to all the strains present locally, to give an acceptable level of protection. A vaccine developed for one locality may not be protective in another, because of
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The precise incidence of the disease is unknown, as diagnostic facilities are not available in much of its large native range, which spans vast regions of equatorial jungle to the subtropics. In rural Thailand and Laos, murine and scrub typhus account for around a quarter of all adults presenting to
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in 1942–43, and mentions that to be hospital-evacuated, Allied soldiers (who cycled forces) had to run a fever of 102 Â°F (39 Â°C), and that sickness casualties outnumbered weapons-inflicted casualties 5:1. Similarly, the illness was a casualty producer in all the jungle fighting of the land
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It affects females more than males in Korea, but not in Japan, which may be because sex-differentiated cultural roles have women tending garden plots more often, thus being exposed to vegetation inhabited by chiggers. The incidence is increasing in the southern part of the Indian subcontinent and in
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can be identified, it is quite diagnostic of scrub typhus, but this can be unreliable on dark skin, and moreover, the site of eschar which is usually where the mite bites is often located in covered areas. Unless it is actively searched for, the eschar can easily be missed. History of mite bite is
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in a classified project called "Operation Tyburn"), but the vaccine was not used. The first known batch of scrub typhus vaccine actually used to inoculate human subjects was dispatched to India for use by Allied Land Forces, South-East Asia Command in June 1945. By December 1945, 268,000 cc had
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Suttinont C, Losuwanaluk K, Niwatayakul K, Hoontrakul S, Intaranongpai W, Silpasakorn S, Suwancharoen D, Panlar P, Saisongkorh W (June 2006). "Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study".
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been dispatched. The vaccine was produced at Wellcome's laboratory at Ely Grange, Frant, Sussex. An attempt to verify the efficacy of the vaccine by using a placebo group for comparison was vetoed by the military commanders, who objected to the experiment.
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hospital with fever and negative blood cultures. The incidence in Japan has fallen over the past few decades, probably due to land development driving decreasing exposure, and many prefectures report fewer than 50 cases per year.
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Watt G, Chouriyagune C, Ruangweerayud R, Watcharapichat P, Phulsuksombati D, Jongsakul K, Teja-Isavadharm P, Bhodhidatta D, Corcoran KD (1996). "Scrub typhus infections poorly responsive to antibiotics in northern Thailand".
289:, but these are not routinely available and the results do not always correlate with serological testing, and are affected by prior antibiotic treatment. The currently available diagnostic methods have been summarised. 217:), which are found in areas of heavy scrub vegetation. The mites feed on infected rodent hosts and subsequently transmit the parasite to other rodents and humans. The bite of this mite leaves a characteristic black 482:
Scrub typhus was first reported in Chile in 2006. This is likely the result of underdiagnosis and underreporting and not of a recent spread to Chile. In January 2020 the disease was for the first time reported in
472:. Where the Allies had bases, they could remove and cut back vegetation, or use DDT as a prophylaxis area barrier treatment, so mite- and tick-induced sickness rates in forces off the front lines were diminished. 2505: 2490: 250:
In endemic areas, diagnosis is generally made on clinical grounds alone. However, overshadowing of the diagnosis is quite often as the clinical symptoms overlap with other infectious diseases such as
443:, although war records frequently lack definitive diagnoses, and many records of "high fever" evacuations were also likely to be other tropical illnesses. In the chapter entitled "The Green War", 1948:
Watt G, Kantipong P, Jongsakul K, Watcharapichat P, Phulsuksombati D, Strickman D (2000). "Doxycycline and rifampicin for mild scrub-typhus infections in northern Thailand: a randomised trial".
271:. Again, this is often unavailable in most endemic areas, since the serological test involved is not included in the routine screening tests for PUO, especially in Burma (Myanmar). 2597: 1075:
Pradutkanchana J, Silpapojakul K, Paxton H, Pradutkanchana S, Kelly DJ, Strickman D (1997). "Comparative evaluation of four serodiagnostic tests for scrub typhus in Thailand".
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The choice of laboratory test is not straightforward, and all currently available tests have their limitations. The cheapest and most easily available serological test is the
4149: 4419: 2590: 1239:"Scrub typhus serologic testing with the indirect immunofluorescence method as a diagnostic gold standard: a lack of consensus leads to a lot of confusion" 1202:
Kelly DJ, Wong PW, Gan E, Lewis GE Jr (1988). "Comparative evaluation of the indirect immunoperoxidase test for the serodiagnosis of rickettsial disease".
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The disease was also a problem for US troops stationed in Japan after WWII, and was variously known as "Shichitƍ fever" (by troops stationed in the
382:, died after accidentally pricking her finger with a needle containing scrub typhus while inoculating a mouse in an attempt to develop a vaccine. 5170: 2583: 644:(Rickettsiales: Rickettsiaceae) in unengorged chiggers (Acari: Trombiculidae) from Oita Prefecture, Japan, by nested polymerase chain reaction". 320:
are alternatives. Azithromycin is an alternative in children and pregnant women with scrub typhus, and when doxycycline resistance is suspected.
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Phongmany S, Rolain JM, Phetsouvanh R, Blacksell SD, Soukkhaseum V, Rasachack B, Phiasakha K, Soukkhaseum S, Frichithavong K (February 2006).
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Mathai E, Rolain JM, Verghese L, Mathai M, Jasper P, Verghese G, Raoult D (2003). "Case reports: scrub typhus during pregnancy in India".
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Sonthayanon P, Chierakul W, Wuthiekanun V, Blacksell SD, Pimda K, Suputtamongkol Y, Pukrittayakamee S, White NJ, Day NP (December 2006).
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Without treatment, the disease is often fatal. Since the use of antibiotics, case fatalities have decreased from 4–40% to less than 2%.
5134: 4721: 2151:"Antigenic relationship among the eight prototype and new serotype strains of Orientia tsutsugamushi revealed by monoclonal antibodies" 2049: 1992: 1664:
Phimda K, Hoontrakul S, Suttinont C, Chareonwat S, Losuwanaluk K, Chueasuwanchai S, Chierakul W, Suwancharoen D, Silpasakorn S (2007).
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orderly Raphael Oimbari, near Buna on 25 December 1942. Whittington died in February 1943 from the effects of bush typhus. (Picture by
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Kelly DJ, Fuerst PA, Ching WM, Richards AL (2009). "Scrub typhus: The geographic distribution of phenotypic and genotypic variants of
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into northern Australia in the south, and to Pakistan and Afghanistan in the west. It may also be endemic in parts of South America.
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Tseng BY, Yang HH, Liou JH, Chen LK, Hsu YH (February 2008). "Immunohistochemical study of scrub typhus: a report of two cases".
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Tay ST, Nazma S, Rohani MY (1996). "Diagnosis of scrub typhus in Malaysian aborigines using nested polymerase chain reaction".
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is an alternative. Strains that are resistant to doxycycline and chloramphenicol have been reported in northern Thailand.
4632: 4194: 3413: 3158: 5082: 4427: 4614: 2839: 1758:"Azithromycin Activities against Orientia tsutsugamushi Strains Isolated in Cases of Scrub Typhus in Northern Thailand" 5040: 4778: 4637: 4540: 2967: 2610: 2296: 4448: 4435: 3403: 976: 933: 890: 4946: 4522: 3408: 2949: 977:"Comparative research on epidemiological aspects of tsutsugamushi disease (scrub typhus) between Korea and Japan" 776: 4687: 4509: 4463: 4374: 4364: 2981: 2575: 4071: 2339:
War epidemics: an historical geography of infectious diseases in military conflict and civil strife, 1850–2000
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Mahajan SK, Rolain JM, Sankhyan N, Kaushal RK, Raoult D (2008). "Pediatric scrub typhus in Indian Himalayas".
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Bozeman FM & Elisberg BL (1963). "Serological diagnosis of scrub typhus by indirect immunofluorescence".
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GonzĂĄlez C (January 29, 2020). "Una bacteria presente en ĂĄcaros causa un raro tipo de infecciĂłn en el sur".
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Ogawa M, Hagiwara T, Kishimoto T, Shiga S, Yoshida Y, Furuya Y, Kaiho I, Ito T, Nemoto H (1 August 2002).
5119: 4740: 4652: 3628: 3622: 3238: 279: 196: 5139: 4941: 3707: 230:). This extends from northern Japan and far-eastern Russia in the north, to the territories around the 1389:"Usefulness of nested PCR for the diagnosis of scrub typhus in clinical practice: A prospective study" 4667: 4443: 3428: 3263: 3232: 3162: 2943: 2685: 332:. Combination therapy with doxycycline and rifampicin is not recommended due to possible antagonism. 286: 259: 164: 459:
over extremely harsh terrains under intense hardships— fought during a six-month span all along the
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identifies that the disease was one of a number of debilitating afflictions affecting both sides on
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occur in the late phase of illness. It has particularly been shown to be the most common cause of
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World War II provides some indicators that the disease is endemic to undeveloped areas in all of
1155:"Serodiagnosis of tsutsugamushi fever (scrub typhus) by the indirect immunoperoxidase technique" 4647: 4599: 4589: 4584: 4473: 4158: 3923: 3841: 3800: 3796: 3677: 3671: 3438: 3148: 3083: 2877: 2783: 2755: 2689: 425: 372:
antigenic variation. This complexity continues to hamper efforts to produce a viable vaccine.
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Scrub typhus is endemic to a part of the world known as the tsutsugamushi triangle (after
95: 8: 5011: 5006: 4916: 4842: 4832: 4806: 4802: 4677: 4483: 4394: 4166: 4079: 4024: 3693: 3569: 3514: 3462: 3381: 3324: 3277: 3212: 3060: 3052: 3046: 2763: 2749: 2618: 2509: 2024: 465: 364: 352: 576: 5062: 4973: 4384: 4369: 4359: 4067: 3978: 3479: 3468: 3389: 3333: 3121: 2819: 2805: 2735: 2712: 2365: 2180: 2167: 2150: 2095: 2070: 1973: 1892:"Efficacy of azithromycin for treatment of mild scrub-typhus infections in South Korea" 1738: 1690: 1665: 1641: 1608: 1544: 1495: 1470: 1342: 1135: 1047: 1022: 871: 822: 797: 713: 669: 617: 590: 556: 448: 183:
and abnormal liver function tests are commonly seen in the early phase of the illness.
2514: 1961: 1926: 1532: 1179: 1154: 1088: 934:"Annual incidence of tsutsugamushi disease in Miyazaki prefecture, Japan in 2001-2005" 754: 737: 544: 5175: 5087: 4767: 4478: 4052: 4018: 3882: 3814: 3577: 3555: 3524: 2975: 2741: 2531: 2431: 2410:"Scrub typhus in Japan: Epidemiology and clinical features of cases reported in 1998" 2379: 2342: 2317: 2292: 2267: 2219: 2172: 2131: 2100: 2000: 1965: 1930: 1872: 1828: 1787: 1782: 1757: 1742: 1730: 1695: 1646: 1628: 1589: 1536: 1500: 1451: 1410: 1369: 1334: 1330: 1299: 1260: 1219: 1184: 1127: 1092: 1052: 996: 953: 910: 863: 827: 759: 718: 661: 622: 560: 548: 484: 444: 58: 3496: 3453: 3348: 2184: 1977: 1548: 1387:
Kim DM, Yun NR, Yang TY, Lee JH, Yang JT, Shim SK, Choi EN, Park MY, Lee SH (2006).
1346: 1170: 1139: 1074: 875: 5124: 5045: 4859: 4827: 4043: 3958: 3749: 3596: 3583: 3398: 3015: 2997: 2904: 2863: 2791: 2661: 2560: 2421: 2211: 2162: 2090: 2082: 1957: 1922: 1862: 1818: 1777: 1769: 1722: 1685: 1677: 1636: 1624: 1620: 1579: 1528: 1490: 1482: 1441: 1430:"Rapid diagnosis of scrub typhus in rural Thailand using polymerase chain reaction" 1400: 1326: 1291: 1250: 1211: 1174: 1166: 1119: 1084: 1042: 1034: 988: 945: 902: 855: 817: 809: 749: 708: 700: 673: 653: 612: 602: 540: 99: 2316:. Cave Junction, Oregon: Oregon Institute of Science & Medicine. p. 309. 5165: 5018: 4906: 4730: 4662: 4569: 4389: 4268: 3993: 3914: 3868: 3773: 3713: 3648: 3590: 3559: 3551: 3254: 3224: 3218: 3101: 2930: 2854: 2681: 2369: 1666:"Doxycycline versus Azithromycin for Treatment of Leptospirosis and Scrub Typhus" 1561: 1517: 783: 607: 400: 309: 275: 176: 2605: 2525: 1471:"Effects of Antibiotic Treatment on the Results of Nested PCRs for Scrub Typhus" 992: 949: 906: 5144: 5023: 4926: 4756: 4622: 4564: 4549: 4409: 4340: 4093: 3743: 3737: 3600: 3338: 2869: 2636: 2606: 2563: 2536: 1446: 1429: 1123: 1038: 844: 657: 429: 395: 379: 348: 102: 2499: 2426: 1867: 1850: 1726: 1584: 1563: 1562:
Kollars TM, Bodhidatta D, Phulsuksombati D, Tippayachai B, Coleman RE (2003).
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Watt G, Kantipong P, Jongsakul K, Watcharapichat P, Phulsuksombati D (1999).
1632: 859: 321: 131:. The disease is thus frequently classified separately from the other typhi. 92: 1278:
Eamsila C, Singsawat P, Duangvaraporn A, Strickman D (1996). "Antibodies to
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Manchester, p. Six months to recapture Buna and Gona from July 21–22, 1942
2135: 1947: 1832: 1540: 1373: 1303: 1223: 1188: 1096: 891:"Scrub typhus (tsutsugamushi disease) in Kanagawa Prefecture in 2001–2005" 795: 704: 5114: 4822: 4716: 4682: 4672: 4504: 4314: 4284: 4127: 3659: 3614: 3565: 3269: 3021: 2456: 1681: 1663: 1486: 476: 405: 301: 255: 231: 192: 184: 41: 2482: 1004: 961: 918: 432:; and before 1944, no effective antibiotics or vaccines were available. 5002: 4997: 4325: 4275: 4248: 3033: 1890:<Please add first missing authors to populate metadata.> (2003). 452: 356: 325: 180: 121: 394:
An Australian soldier, Private George "Dick" Whittington, is aided by
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Jain P, Prakash S, Tripathi PK, Chauhan A, Gupta S, Sharma U (2018).
375: 1755: 1564:"Short report: variation in the 56-kD type-specific antigen gene of 1317:
Watt G, Parola P (2003). "Scrub typhus and tropical rickettsioses".
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Scrub typhus is transmitted by some species of trombiculid mites ("
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Koh GC, Maude RJ, Paris DH, Newton PN, Blacksell SD (March 2010).
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Katayama T, Hara M, Furuya Y, Nikkawa T, Ogasawara H (June 2006).
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Although the disease is similar in presentation to other forms of
5057: 4968: 4896: 4812: 4399: 3874: 3820: 3174: 3139: 2407: 2054: 738:"Orientia tsutsugamushi infection: overview and immune responses" 436: 344: 5052: 2652: 2494: 417: 263: 218: 168: 109: 79: 1152: 4911: 1237:
Blacksell SD, Bryant NJ, Paris, DH, Sakoda Y, Day NP (2007).
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Pham XD, Otsuka Y, Suzuki H, Takaoka H (2001). "Detection of
413: 148: 140: 117: 1712: 1236: 1109: 424:. Several members of the U.S. Army's 5307th Composite Unit ( 4980: 4901: 932:
Yamamoto S, Ganmyo H, Iwakiri A, Suzuki S (December 2006).
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Kim YS, Lee HJ, Chang M, Son SK, Rhee YE, Shim SK (2006).
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cannot be used safely in pregnancy and is associated with
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Severe epidemics of the disease occurred among troops in
2197: 2032:"AWIC Newsletter: The Cotton Rat In Biomedical Research" 1807:"Azithromycin therapy for scrub typhus during pregnancy" 278:, but this is notoriously unreliable. The best test is 1201: 777:
Deadly scrub typhus bacteria confirmed in South America
639: 428:) died of the disease, as well as many soldiers in the 221:
that is useful to the doctor for making the diagnosis.
2291:. Barnsley, South Yorkshire: Leo Cooper. p. 212. 1607:
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Little Brown Company. pp.  2058:. Millbanksystems. April 2, 1946. 4449:Primary inoculation tuberculosis 3184:Neisseria gonorrhoeae/gonococcus 3159:Waterhouse–Friderichsen syndrome 2050:"Scrub Typhus Vaccine, Far East" 1889: 1331:10.1097/00001432-200310000-00009 975:Bang HA, Lee MJ, Lee WC (2008). 4947:Gram-negative toe web infection 4523:Group JK corynebacterium sepsis 2950:Human granulocytic anaplasmosis 2401: 2392: 2330: 2305: 2280: 2230: 2142: 2111: 2062: 2055:Parliamentary Debates (Hansard) 2042: 1984: 1941: 1906: 1883: 1798: 1749: 1706: 1657: 1600: 1555: 1511: 1462: 1421: 1380: 1353: 1310: 1271: 1230: 1195: 1171:10.1128/JCM.15.6.1128-1132.1982 1146: 1103: 925: 882: 838: 520:. London: Sassell. p. 177. 300:The drug most commonly used is 4688:Ehrlichiosis ewingii infection 4510:Cutaneous diphtheria infection 4464:Tuberculosis cutis orificialis 4375:Borderline tuberculoid leprosy 4365:Borderline lepromatous leprosy 2982:Ehrlichiosis ewingii infection 1625:10.1002/14651858.CD002150.pub2 789: 786:. ScienMag (September 8, 2016) 770: 680: 633: 582: 509: 1: 4712:Primary gonococcal dermatitis 4658:Flinders Island spotted fever 2798:Flinders Island spotted fever 1962:10.1016/S0140-6736(00)02728-8 1927:10.1016/S0035-9203(03)80032-9 1533:10.1016/S0140-6736(96)02501-9 1089:10.1016/S0035-9203(97)90266-2 755:10.1016/S1286-4579(00)01352-6 579:, accessdate: 16 October 2011 545:10.1016/S1607-551X(08)70103-7 502: 5100:Blistering distal dactylitis 4628:Rocky Mountain spotted fever 4516:Arcanobacterium haemolyticum 4469:Tuberculosis verrucosa cutis 4253:Chronic recurrent erysipelas 3968:Stenotrophomonas maltophilia 3292:Burkholderia cepacia complex 2728:Rocky Mountain spotted fever 2314:Jungle Snafus...And Remedies 2204:Clinical Infectious Diseases 1715:Indian Journal of Pediatrics 608:10.1371/journal.pntd.0006346 292: 245: 7: 5120:Blastomycosis-like pyoderma 4741:Chromobacteriosis infection 4653:Mediterranean spotted fever 3629:Far East scarlet-like fever 3623:Yersinia pseudotuberculosis 3239:Chromobacteriosis infection 1762:Antimicrob Agents Chemother 1670:Antimicrob Agents Chemother 1023:"Diagnosis of scrub typhus" 993:10.7883/yoken.JJID.2008.148 950:10.7883/yoken.JJID.2006.404 907:10.7883/yoken.JJID.2006.207 490: 485:Chile's southernmost region 280:indirect immunofluorescence 197:acute encephalitis syndrome 155:. More virulent strains of 139:Signs and symptoms include 10: 5197: 5140:Tick-borne lymphadenopathy 4942:Gram-negative folliculitis 2287:Grant, Ian Lyall- (2003). 2149:Kang JS, Chang WH (1999). 1447:10.4269/ajtmh.2006.75.1099 1124:10.3181/00379727-112-28107 1039:10.4269/ajtmh.2010.09-0233 658:10.1603/0022-2585-38.2.308 385: 335: 4959: 4879: 4858: 4749: 4696: 4557: 4548: 4539: 4492: 4444:Papulonecrotic tuberculid 4429:Mycobacterium haemophilum 4348: 4339: 4307: 4282: 4266: 4213: 4183: 4174: 4165: 4042: 4004: 3977: 3957: 3913: 3858: 3831: 3786: 3760: 3724: 3656: 3647: 3539: 3504: 3495: 3452: 3429:Hemolytic-uremic syndrome 3347: 3332: 3323: 3264:Burkholderia pseudomallei 3253: 3233:Chromobacterium violaceum 3200: 3173: 3163:Meningococcal septicaemia 3138: 3129: 3120: 3032: 3005: 2996: 2944:Anaplasma phagocytophilum 2929: 2894: 2853: 2711: 2700: 2651: 2635: 2626: 2617: 2546: 2476: 2460:(in Spanish). p. A9. 2427:10.4269/ajtmh.2002.67.162 2368:(1978). "The Green War". 2069:Thomson Walker W (1947). 1868:10.4269/ajtmh.2006.75.955 1727:10.1007/s12098-008-0198-z 1585:10.4269/ajtmh.2003.68.299 1406:10.4269/ajtmh.2006.75.542 1296:10.4269/ajtmh.1996.55.556 1216:10.4269/ajtmh.1988.38.400 355:infecting around 300,000 287:polymerase chain reaction 260:pyrexia of unknown origin 202: 165:intravascular coagulation 153:gastrointestinal symptoms 116:is no longer included in 57: 48: 39: 31: 26: 4937:Lymphogranuloma venereum 4643:Flea-borne spotted fever 4616:Rickettsia aeschlimannii 4610:American tick bite fever 4320:Erysipeloid of Rosenbach 4235:Streptococcal intertrigo 3904:Plesiomonas shigelloides 3686:Brazilian purpuric fever 3303:Bordetella parapertussis 3092:Bartonella bacilliformis 2911:Flea-borne spotted fever 2841:Rickettsia aeschlimannii 2834:Rickettsia aeschlimannii 2826:American tick bite fever 2289:Burma: The Turning Point 2238:"Death from Scrub Fever" 2120:Rickettsia tsutsugamushi 1915:Trans R Soc Trop Med Hyg 1469:Kim DM, Byun JN (2008). 1077:Trans R Soc Trop Med Hyg 860:10.1179/136485906X112158 214:Leptotrombidium deliense 5068:Trichomycosis axillaris 4605:African tick bite fever 4580:North Asian tick typhus 4500:Cutaneous actinomycosis 4072:Guillain–BarrĂ© syndrome 3988:Cardiobacterium hominis 3948:Acinetobacter baumannii 3890:Vibrio parahaemolyticus 3609:Yersinia enterocolitica 3376:Klebsiella granulomatis 2812:African tick bite fever 2770:North Asian tick typhus 1805:Choi EK, Pai H (1998). 4780:Haemophilus influenzae 4724:Pasteurella hemolytica 4648:Japanese spotted fever 4600:Bacillary angiomatosis 4590:Flying squirrel typhus 4585:Queensland tick typhus 4474:Tuberculous cellulitis 4437:Mycobacterium kansasii 4159:Bacterial skin disease 3924:Pseudomonas aeruginosa 3842:Francisella tularensis 3801:Legionella longbeachae 3797:Legionella pneumophila 3439:Enterobacter aerogenes 3084:Bacillary angiomatosis 2878:Orientia tsutsugamushi 2784:Queensland tick typhus 2756:Japanese spotted fever 2690:Flying squirrel typhus 2200:Orientia tsutsugamushi 2087:10.1136/bmj.1.4501.484 2071:"Scrub Typhus Vaccine" 1774:10.1128/AAC.43.11.2817 1566:Orientia tsutsugamushi 1280:Orientia tsutsugamushi 848:Ann Trop Med Parasitol 814:10.3201/eid1202.050900 642:Orientia tsutsugamushi 577:Pediatric Scrub Typhus 516:Slim, William (1956). 455:in the running bloody 409: 369:Orientia tsutsugamushi 88:Orientia tsutsugamushi 84:intracellular parasite 51:Orientia tsutsugamushi 5095:Elephantiasis nostras 5073:Necrotizing fasciitis 4986:Hospital furunculosis 4668:Brill–Zinsser disease 4299:Dermatitis gangrenosa 3941:Moraxella catarrhalis 3807:Legionnaires' disease 3728:Pasteurella multocida 3358:Klebsiella pneumoniae 3155:Meningococcal disease 2962:Ehrlichia chaffeensis 2722:Rickettsia rickettsii 2686:Brill–Zinsser disease 2676:Rickettsia prowazekii 1902:: abstract no. L–182. 1434:Am. J. Trop. Med. Hyg 1112:Proc Soc Exp Biol Med 1027:Am. J. Trop. Med. Hyg 705:10.4269/ajtmh.16-0583 533:Kaohsiung J. Med. Sci 393: 167:. Morbilliform rash, 5130:Chronic lymphangitis 4799:Hot tub folliculitis 4788:Pseudomonal pyoderma 4415:Miliary tuberculosis 4405:Lichen scrofulosorum 4205:Toxic shock syndrome 4102:Helicobacter cinaedi 4062:Campylobacter jejuni 4015:Aeromonas hydrophila 3897:Vibrio alginolyticus 3548:Shigella dysenteriae 3486:Citrobacter freundii 3443:Enterobacter cloacae 3299:Bordetella pertussis 2778:Rickettsia australis 2264:Red mites and typhus 1682:10.1128/AAC.00508-07 1487:10.1128/JCM.00634-08 1319:Curr Opin Infect Dis 802:Emerging Infect. Dis 470:Guadalcanal campaign 5181:Tick-borne diseases 5019:Acute lymphadenitis 5012:Perianal cellulitis 5007:Pyogenic paronychia 4917:Chlamydia infection 4833:Granuloma inguinale 4807:Green nail syndrome 4803:Ecthyma gangrenosum 4678:Cat-scratch disease 4484:Tuberculoid leprosy 4395:Lepromatous leprosy 4242:Streptococcus iniae 4080:Helicobacter pylori 3570:Bacillary dysentery 3515:Salmonella enterica 3463:Serratia marcescens 3382:Granuloma inguinale 3278:Burkholderia mallei 3213:Eikenella corrodens 3061:Bartonella quintana 3053:Cat-scratch disease 3047:Bartonella henselae 2764:Rickettsia sibirica 2750:Rickettsia japonica 1956:(9235): 1057–1061. 1282:in Thai soldiers". 518:Defeat Into Victory 466:New Guinea campaign 426:Merrill's Marauders 365:antigenic variation 353:Wellcome Foundation 179:are typical signs. 5063:Pitted keratolysis 4974:Periapical abscess 4385:Erythema induratum 4370:Borderline leprosy 4360:Aquarium granuloma 4068:Campylobacteriosis 3979:Cardiobacteriaceae 3480:Citrobacter koseri 3390:Klebsiella oxytoca 2820:Rickettsia parkeri 2806:Rickettsia africae 2736:Rickettsia conorii 2547:External resources 2366:William Manchester 2312:Kearny CH (1997). 782:2019-09-23 at the 595:PLOS Negl Trop Dis 449:William Manchester 410: 351:in 1937 (with the 135:Signs and symptoms 64:Infectious disease 5153: 5152: 5088:Fournier gangrene 4955: 4954: 4854: 4853: 4795:hot-foot syndrome 4768:Vibrio vulnificus 4535: 4534: 4531: 4530: 4479:Tuberculous gumma 4335: 4334: 4125: 4124: 4121: 4120: 4053:Campylobacterales 4038: 4037: 4019:Aeromonas veronii 3883:Vibrio vulnificus 3815:Coxiella burnetii 3782: 3781: 3708:H. parainfluenzae 3643: 3642: 3639: 3638: 3578:Proteus mirabilis 3525:Paratyphoid fever 3414:Enterohemorrhagic 3334:Enterobacteriales 3319: 3318: 3249: 3248: 3116: 3115: 3112: 3111: 3098:Carrion's disease 2992: 2991: 2976:Ehrlichia ewingii 2925: 2924: 2921: 2920: 2742:Boutonneuse fever 2573: 2572: 2414:Am J Trop Med Hyg 2385:978-0-316-54498-6 2348:978-0-19-823364-0 2323:978-1-884067-10-5 2273:978-0-485-26318-3 2155:Microbiol Immunol 2006:978-0-323-04885-9 1855:Am J Trop Med Hyg 1768:(11): 2817–2818. 1572:Am J Trop Med Hyg 1393:Am J Trop Med Hyg 1284:Am J Trop Med Hyg 1204:Am J Trop Med Hyg 477:Izu Seven Islands 445:General MacArthur 199:in Bihar, India. 177:lymphadenopathies 96:α-proteobacterium 69: 68: 21:Medical condition 5188: 5125:Bullous impetigo 5046:Sycosis vulgaris 4860:Campylobacterota 4809: 4555: 4554: 4546: 4545: 4346: 4345: 4181: 4180: 4172: 4171: 4152: 4145: 4138: 4129: 4128: 4049: 4048: 3959:Xanthomonadaceae 3767: 3750:Actinobacillosis 3731: 3664: 3654: 3653: 3584:Proteus vulgaris 3502: 3501: 3399:Escherichia coli 3345: 3344: 3330: 3329: 3205: 3136: 3135: 3127: 3126: 3016:Brucella abortus 3003: 3002: 2998:Hyphomicrobiales 2905:Rickettsia felis 2864:Rickettsia akari 2792:Rickettsia honei 2709: 2708: 2662:Rickettsia typhi 2649: 2648: 2633: 2632: 2624: 2623: 2600: 2593: 2586: 2577: 2576: 2474: 2473: 2462: 2461: 2451: 2440: 2439: 2429: 2405: 2399: 2396: 2390: 2389: 2362: 2353: 2352: 2334: 2328: 2327: 2309: 2303: 2302: 2284: 2278: 2277: 2262:Audy JR (1968). 2259: 2253: 2252: 2250: 2249: 2242:Kalgoorlie Miner 2234: 2228: 2227: 2195: 2189: 2188: 2170: 2146: 2140: 2139: 2115: 2109: 2108: 2098: 2066: 2060: 2059: 2046: 2040: 2039: 2034:. Archived from 2028: 2022: 2021: 2019: 2018: 2009:. Archived from 1988: 1982: 1981: 1945: 1939: 1938: 1910: 1904: 1903: 1887: 1881: 1880: 1870: 1846: 1837: 1836: 1826: 1802: 1796: 1795: 1785: 1753: 1747: 1746: 1710: 1704: 1703: 1693: 1661: 1655: 1654: 1644: 1604: 1598: 1597: 1587: 1559: 1553: 1552: 1515: 1509: 1508: 1498: 1475:J Clin Microbiol 1466: 1460: 1459: 1449: 1425: 1419: 1418: 1408: 1384: 1378: 1377: 1357: 1351: 1350: 1314: 1308: 1307: 1275: 1269: 1268: 1258: 1234: 1228: 1227: 1199: 1193: 1192: 1182: 1159:J Clin Microbiol 1150: 1144: 1143: 1107: 1101: 1100: 1072: 1061: 1060: 1050: 1018: 1009: 1008: 1003:. Archived from 981:Jpn J Infect Dis 972: 966: 965: 960:. Archived from 938:Jpn J Infect Dis 929: 923: 922: 917:. Archived from 895:Jpn J Infect Dis 886: 880: 879: 842: 836: 835: 825: 793: 787: 774: 768: 767: 757: 733: 727: 726: 716: 699:(6): 1223–1224. 684: 678: 677: 637: 631: 630: 620: 610: 586: 580: 574: 565: 564: 528: 522: 521: 513: 378:, an Australian 347:occurred in the 227:O. tsutsugamushi 211:", particularly 157:O. tsutsugamushi 44: 24: 23: 5196: 5195: 5191: 5190: 5189: 5187: 5186: 5185: 5156: 5155: 5154: 5149: 4961: 4951: 4875: 4850: 4786: 4745: 4731:Meningococcemia 4692: 4663:Verruga peruana 4570:Epidemic typhus 4527: 4488: 4390:Histoid leprosy 4351: 4331: 4303: 4278: 4269:Corynebacterium 4262: 4209: 4161: 4156: 4126: 4117: 4034: 4000: 3973: 3953: 3915:Pseudomonadales 3909: 3869:Vibrio cholerae 3854: 3827: 3778: 3761: 3756: 3725: 3720: 3657: 3635: 3591:Yersinia pestis 3535: 3491: 3448: 3404:Enterotoxigenic 3336: 3315: 3255:Burkholderiales 3245: 3219:Kingella kingae 3201: 3196: 3169: 3108: 3102:Verruga peruana 3028: 2988: 2931:Anaplasmataceae 2917: 2890: 2849: 2703: 2696: 2682:Epidemic typhus 2640: 2613: 2604: 2574: 2569: 2568: 2542: 2541: 2485: 2471: 2466: 2465: 2452: 2443: 2406: 2402: 2397: 2393: 2386: 2371:American Caesar 2363: 2356: 2349: 2335: 2331: 2324: 2310: 2306: 2299: 2285: 2281: 2274: 2260: 2256: 2247: 2245: 2236: 2235: 2231: 2210:(s3): S203–30. 2196: 2192: 2147: 2143: 2116: 2112: 2081:(4501): 484–7. 2067: 2063: 2048: 2047: 2043: 2030: 2029: 2025: 2016: 2014: 2007: 1989: 1985: 1946: 1942: 1911: 1907: 1888: 1884: 1847: 1840: 1811:Clin Infect Dis 1803: 1799: 1754: 1750: 1711: 1707: 1662: 1658: 1619:(9): CD002150. 1605: 1601: 1560: 1556: 1527:(9020): 86–89. 1516: 1512: 1467: 1463: 1440:(6): 1099–102. 1426: 1422: 1385: 1381: 1358: 1354: 1315: 1311: 1276: 1272: 1243:Clin Infect Dis 1235: 1231: 1200: 1196: 1151: 1147: 1108: 1104: 1073: 1064: 1019: 1012: 973: 969: 930: 926: 887: 883: 843: 839: 794: 790: 784:Wayback Machine 775: 771: 742:Microbes Infect 734: 730: 687:Park J (2016). 685: 681: 638: 634: 601:(3): e0006346. 587: 583: 575: 568: 529: 525: 514: 510: 505: 493: 464:battles of the 441:Pacific theater 388: 338: 310:chloramphenicol 295: 276:Weil-Felix test 248: 205: 147:, muscle pain, 137: 22: 17: 12: 11: 5: 5194: 5184: 5183: 5178: 5173: 5168: 5151: 5150: 5148: 5147: 5145:Tropical ulcer 5142: 5137: 5132: 5127: 5122: 5117: 5112: 5107: 5102: 5097: 5092: 5091: 5090: 5085: 5075: 5070: 5065: 5060: 5055: 5050: 5049: 5048: 5043: 5032: 5031: 5026: 5024:Pilonidal cyst 5021: 5016: 5015: 5014: 5009: 4995: 4990: 4989: 4988: 4978: 4977: 4976: 4965: 4963: 4957: 4956: 4953: 4952: 4950: 4949: 4944: 4939: 4934: 4929: 4927:Rat-bite fever 4924: 4919: 4914: 4909: 4904: 4899: 4894: 4889: 4883: 4881: 4877: 4876: 4874: 4873: 4864: 4862: 4856: 4855: 4852: 4851: 4849: 4848: 4840: 4835: 4830: 4825: 4820: 4815: 4810: 4784: 4776: 4771: 4764: 4759: 4757:Pasteurellosis 4753: 4751: 4747: 4746: 4744: 4743: 4738: 4733: 4728: 4719: 4714: 4700: 4698: 4694: 4693: 4691: 4690: 4685: 4680: 4675: 4670: 4665: 4660: 4655: 4650: 4645: 4640: 4635: 4630: 4625: 4623:Rickettsialpox 4620: 4612: 4607: 4602: 4597: 4592: 4587: 4582: 4577: 4572: 4567: 4565:Endemic typhus 4561: 4559: 4552: 4550:Pseudomonadota 4543: 4537: 4536: 4533: 4532: 4529: 4528: 4526: 4525: 4520: 4512: 4507: 4502: 4496: 4494: 4490: 4489: 4487: 4486: 4481: 4476: 4471: 4466: 4461: 4456: 4451: 4446: 4441: 4433: 4425: 4417: 4412: 4410:Lupus vulgaris 4407: 4402: 4397: 4392: 4387: 4382: 4377: 4372: 4367: 4362: 4356: 4354: 4350:Mycobacterium- 4343: 4341:Actinomycetota 4337: 4336: 4333: 4332: 4330: 4329: 4322: 4317: 4311: 4309: 4305: 4304: 4302: 4301: 4296: 4290: 4288: 4280: 4279: 4274: 4272: 4264: 4263: 4261: 4260: 4255: 4246: 4237: 4232: 4227: 4221: 4219: 4211: 4210: 4208: 4207: 4202: 4197: 4191: 4189: 4186:Staphylococcus 4178: 4169: 4163: 4162: 4155: 4154: 4147: 4140: 4132: 4123: 4122: 4119: 4118: 4116: 4115: 4114: 4113: 4098: 4097: 4096: 4094:Gastric cancer 4076: 4075: 4074: 4057: 4055: 4046: 4040: 4039: 4036: 4035: 4033: 4032: 4031: 4030: 4010: 4008: 4002: 4001: 3999: 3998: 3997: 3996: 3983: 3981: 3975: 3974: 3972: 3971: 3963: 3961: 3955: 3954: 3952: 3951: 3944: 3937: 3936: 3935: 3919: 3917: 3911: 3910: 3908: 3907: 3900: 3893: 3886: 3879: 3878: 3877: 3864: 3862: 3856: 3855: 3853: 3852: 3851: 3850: 3837: 3835: 3829: 3828: 3826: 3825: 3824: 3823: 3811: 3810: 3809: 3792: 3790: 3784: 3783: 3780: 3779: 3777: 3776: 3770: 3768: 3758: 3757: 3755: 3754: 3753: 3752: 3744:Actinobacillus 3740: 3738:Pasteurellosis 3734: 3732: 3722: 3721: 3719: 3718: 3717: 3716: 3704: 3703: 3702: 3690: 3689: 3688: 3683: 3667: 3665: 3651: 3649:Pasteurellales 3645: 3644: 3641: 3640: 3637: 3636: 3634: 3633: 3632: 3631: 3619: 3618: 3617: 3605: 3604: 3603: 3601:Bubonic plague 3587: 3574: 3573: 3572: 3543: 3541: 3537: 3536: 3534: 3533: 3532: 3531: 3510: 3508: 3499: 3493: 3492: 3490: 3489: 3476: 3475: 3474: 3458: 3456: 3450: 3449: 3447: 3446: 3434: 3433: 3432: 3431: 3421: 3416: 3411: 3409:Enteroinvasive 3406: 3394: 3393: 3386: 3385: 3384: 3372: 3371: 3370: 3353: 3351: 3342: 3327: 3321: 3320: 3317: 3316: 3314: 3313: 3312: 3311: 3295: 3288: 3287: 3286: 3274: 3273: 3272: 3259: 3257: 3251: 3250: 3247: 3246: 3244: 3243: 3242: 3241: 3229: 3228: 3227: 3208: 3206: 3198: 3197: 3195: 3194: 3193: 3192: 3179: 3177: 3171: 3170: 3168: 3167: 3166: 3165: 3144: 3142: 3133: 3124: 3118: 3117: 3114: 3113: 3110: 3109: 3107: 3106: 3105: 3104: 3088: 3087: 3086: 3071: 3070: 3069: 3057: 3056: 3055: 3038: 3036: 3034:Bartonellaceae 3030: 3029: 3027: 3026: 3025: 3024: 3011: 3009: 3000: 2994: 2993: 2990: 2989: 2987: 2986: 2985: 2984: 2972: 2971: 2970: 2958: 2957: 2956: 2935: 2933: 2927: 2926: 2923: 2922: 2919: 2918: 2916: 2915: 2914: 2913: 2900: 2898: 2892: 2891: 2889: 2888: 2887: 2886: 2874: 2873: 2872: 2870:Rickettsialpox 2859: 2857: 2851: 2850: 2848: 2847: 2846: 2845: 2830: 2829: 2828: 2816: 2815: 2814: 2802: 2801: 2800: 2788: 2787: 2786: 2774: 2773: 2772: 2760: 2759: 2758: 2746: 2745: 2744: 2732: 2731: 2730: 2717: 2715: 2706: 2698: 2697: 2695: 2694: 2693: 2692: 2672: 2671: 2670: 2657: 2655: 2646: 2637:Rickettsiaceae 2630: 2621: 2615: 2614: 2607:Pseudomonadota 2603: 2602: 2595: 2588: 2580: 2571: 2570: 2567: 2566: 2551: 2550: 2548: 2544: 2543: 2540: 2539: 2528: 2517: 2502: 2486: 2481: 2480: 2478: 2477:Classification 2470: 2469:External links 2467: 2464: 2463: 2441: 2400: 2391: 2384: 2354: 2347: 2329: 2322: 2304: 2297: 2279: 2272: 2254: 2229: 2216:10.1086/596576 2190: 2141: 2110: 2061: 2041: 2038:on 2004-06-10. 2023: 2005: 1983: 1940: 1905: 1882: 1838: 1824:10.1086/517742 1797: 1748: 1705: 1676:(9): 3259–63. 1656: 1599: 1578:(3): 299–300. 1554: 1510: 1461: 1420: 1399:(3): 542–545. 1379: 1352: 1325:(5): 429–436. 1309: 1270: 1256:10.1086/510585 1249:(3): 391–401. 1229: 1194: 1145: 1102: 1062: 1010: 1007:on 2008-09-27. 967: 964:on 2009-08-15. 924: 921:on 2010-05-25. 881: 837: 788: 769: 728: 679: 652:(2): 308–311. 632: 581: 566: 523: 507: 506: 504: 501: 500: 499: 492: 489: 457:Kokoda battles 447:'s biographer 387: 384: 380:bacteriologist 349:United Kingdom 337: 334: 294: 291: 262:(PUO). If the 247: 244: 204: 201: 136: 133: 103:Rickettsiaceae 82:caused by the 67: 66: 61: 55: 54: 46: 45: 37: 36: 33: 29: 28: 20: 15: 9: 6: 4: 3: 2: 5193: 5182: 5179: 5177: 5174: 5172: 5169: 5167: 5164: 5163: 5161: 5146: 5143: 5141: 5138: 5136: 5133: 5131: 5128: 5126: 5123: 5121: 5118: 5116: 5113: 5111: 5108: 5106: 5105:Botryomycosis 5103: 5101: 5098: 5096: 5093: 5089: 5086: 5084: 5081: 5080: 5079: 5076: 5074: 5071: 5069: 5066: 5064: 5061: 5059: 5056: 5054: 5051: 5047: 5044: 5042: 5039: 5038: 5037: 5034: 5033: 5030: 5027: 5025: 5022: 5020: 5017: 5013: 5010: 5008: 5004: 5001: 5000: 4999: 4996: 4994: 4991: 4987: 4984: 4983: 4982: 4981:Boil/furuncle 4979: 4975: 4972: 4971: 4970: 4967: 4966: 4964: 4958: 4948: 4945: 4943: 4940: 4938: 4935: 4933: 4930: 4928: 4925: 4923: 4922:Leptospirosis 4920: 4918: 4915: 4913: 4910: 4908: 4905: 4903: 4900: 4898: 4895: 4893: 4890: 4888: 4885: 4884: 4882: 4878: 4872: 4870: 4866: 4865: 4863: 4861: 4857: 4847: 4845: 4841: 4839: 4836: 4834: 4831: 4829: 4826: 4824: 4821: 4819: 4818:Salmonellosis 4816: 4814: 4811: 4808: 4804: 4800: 4796: 4794: 4789: 4785: 4783: 4781: 4777: 4775: 4774:Rhinoscleroma 4772: 4770: 4769: 4765: 4763: 4760: 4758: 4755: 4754: 4752: 4748: 4742: 4739: 4737: 4734: 4732: 4729: 4727: 4725: 4720: 4718: 4715: 4713: 4709: 4705: 4702: 4701: 4699: 4695: 4689: 4686: 4684: 4681: 4679: 4676: 4674: 4671: 4669: 4666: 4664: 4661: 4659: 4656: 4654: 4651: 4649: 4646: 4644: 4641: 4639: 4636: 4634: 4631: 4629: 4626: 4624: 4621: 4619: 4617: 4613: 4611: 4608: 4606: 4603: 4601: 4598: 4596: 4593: 4591: 4588: 4586: 4583: 4581: 4578: 4576: 4573: 4571: 4568: 4566: 4563: 4562: 4560: 4556: 4553: 4551: 4547: 4544: 4542: 4538: 4524: 4521: 4519: 4517: 4513: 4511: 4508: 4506: 4503: 4501: 4498: 4497: 4495: 4491: 4485: 4482: 4480: 4477: 4475: 4472: 4470: 4467: 4465: 4462: 4460: 4459:Scrofuloderma 4457: 4455: 4452: 4450: 4447: 4445: 4442: 4440: 4438: 4434: 4432: 4430: 4426: 4424: 4422: 4418: 4416: 4413: 4411: 4408: 4406: 4403: 4401: 4398: 4396: 4393: 4391: 4388: 4386: 4383: 4381: 4378: 4376: 4373: 4371: 4368: 4366: 4363: 4361: 4358: 4357: 4355: 4353: 4347: 4344: 4342: 4338: 4328: 4327: 4323: 4321: 4318: 4316: 4313: 4312: 4310: 4306: 4300: 4297: 4295: 4292: 4291: 4289: 4287: 4286: 4281: 4277: 4273: 4271: 4270: 4265: 4259: 4258:Scarlet fever 4256: 4254: 4250: 4247: 4245: 4243: 4238: 4236: 4233: 4231: 4228: 4226: 4223: 4222: 4220: 4218: 4217: 4216:Streptococcus 4212: 4206: 4203: 4201: 4198: 4196: 4193: 4192: 4190: 4188: 4187: 4182: 4179: 4177: 4173: 4170: 4168: 4164: 4160: 4153: 4148: 4146: 4141: 4139: 4134: 4133: 4130: 4112: 4110: 4106: 4105: 4104: 4103: 4099: 4095: 4091: 4090:MALT lymphoma 4087: 4084: 4083: 4082: 4081: 4077: 4073: 4069: 4066: 4065: 4064: 4063: 4059: 4058: 4056: 4054: 4050: 4047: 4045: 4041: 4029: 4027: 4023: 4022: 4021: 4020: 4016: 4012: 4011: 4009: 4007: 4006:Aeromonadales 4003: 3995: 3992: 3991: 3990: 3989: 3985: 3984: 3982: 3980: 3976: 3970: 3969: 3965: 3964: 3962: 3960: 3956: 3950: 3949: 3945: 3943: 3942: 3938: 3934: 3932: 3928: 3927: 3926: 3925: 3921: 3920: 3918: 3916: 3912: 3906: 3905: 3901: 3899: 3898: 3894: 3892: 3891: 3887: 3885: 3884: 3880: 3876: 3873: 3872: 3871: 3870: 3866: 3865: 3863: 3861: 3857: 3849: 3846: 3845: 3844: 3843: 3839: 3838: 3836: 3834: 3833:Thiotrichales 3830: 3822: 3819: 3818: 3817: 3816: 3812: 3808: 3805: 3804: 3803: 3802: 3798: 3794: 3793: 3791: 3789: 3788:Legionellales 3785: 3775: 3772: 3771: 3769: 3766: 3765: 3759: 3751: 3748: 3747: 3746: 3745: 3741: 3739: 3736: 3735: 3733: 3730: 3729: 3723: 3715: 3712: 3711: 3710: 3709: 3705: 3701: 3698: 3697: 3696: 3695: 3691: 3687: 3684: 3682: 3680: 3676: 3675: 3674: 3673: 3672:H. influenzae 3669: 3668: 3666: 3663: 3661: 3655: 3652: 3650: 3646: 3630: 3627: 3626: 3625: 3624: 3620: 3616: 3613: 3612: 3611: 3610: 3606: 3602: 3598: 3595: 3594: 3593: 3592: 3588: 3586: 3585: 3580: 3579: 3575: 3571: 3567: 3564: 3563: 3562: 3561: 3557: 3553: 3549: 3545: 3544: 3542: 3538: 3530: 3529:Salmonellosis 3526: 3522: 3521:Typhoid fever 3519: 3518: 3517: 3516: 3512: 3511: 3509: 3507: 3503: 3500: 3498: 3494: 3488: 3487: 3482: 3481: 3477: 3473: 3471: 3467: 3466: 3465: 3464: 3460: 3459: 3457: 3455: 3451: 3445: 3444: 3440: 3436: 3435: 3430: 3427: 3426: 3425: 3422: 3420: 3417: 3415: 3412: 3410: 3407: 3405: 3401: 3400: 3396: 3395: 3392: 3391: 3387: 3383: 3380: 3379: 3378: 3377: 3373: 3369: 3365: 3364:Rhinoscleroma 3362: 3361: 3360: 3359: 3355: 3354: 3352: 3350: 3346: 3343: 3340: 3335: 3331: 3328: 3326: 3322: 3310: 3307: 3306: 3305: 3304: 3300: 3296: 3294: 3293: 3289: 3285: 3282: 3281: 3280: 3279: 3275: 3271: 3268: 3267: 3266: 3265: 3261: 3260: 3258: 3256: 3252: 3240: 3237: 3236: 3235: 3234: 3230: 3226: 3223: 3222: 3221: 3220: 3215: 3214: 3210: 3209: 3207: 3204: 3199: 3191: 3188: 3187: 3186: 3185: 3181: 3180: 3178: 3176: 3172: 3164: 3160: 3156: 3153: 3152: 3151: 3150: 3146: 3145: 3143: 3141: 3137: 3134: 3132: 3128: 3125: 3123: 3119: 3103: 3099: 3096: 3095: 3094: 3093: 3089: 3085: 3082: 3081: 3080: 3076: 3072: 3068: 3065: 3064: 3063: 3062: 3058: 3054: 3051: 3050: 3049: 3048: 3043: 3042:Bartonellosis 3040: 3039: 3037: 3035: 3031: 3023: 3020: 3019: 3018: 3017: 3013: 3012: 3010: 3008: 3004: 3001: 2999: 2995: 2983: 2980: 2979: 2978: 2977: 2973: 2969: 2966: 2965: 2964: 2963: 2959: 2955: 2951: 2948: 2947: 2946: 2945: 2940: 2937: 2936: 2934: 2932: 2928: 2912: 2909: 2908: 2907: 2906: 2902: 2901: 2899: 2897: 2893: 2885: 2882: 2881: 2880: 2879: 2875: 2871: 2868: 2867: 2866: 2865: 2861: 2860: 2858: 2856: 2852: 2844: 2842: 2838: 2837: 2836: 2835: 2831: 2827: 2824: 2823: 2822: 2821: 2817: 2813: 2810: 2809: 2808: 2807: 2803: 2799: 2796: 2795: 2794: 2793: 2789: 2785: 2782: 2781: 2780: 2779: 2775: 2771: 2768: 2767: 2766: 2765: 2761: 2757: 2754: 2753: 2752: 2751: 2747: 2743: 2740: 2739: 2738: 2737: 2733: 2729: 2726: 2725: 2724: 2723: 2719: 2718: 2716: 2714: 2710: 2707: 2705: 2699: 2691: 2687: 2683: 2680: 2679: 2678: 2677: 2673: 2669: 2668:Murine typhus 2666: 2665: 2664: 2663: 2659: 2658: 2656: 2654: 2650: 2647: 2644: 2643:Rickettsioses 2638: 2634: 2631: 2629: 2628:Rickettsiales 2625: 2622: 2620: 2616: 2612: 2608: 2601: 2596: 2594: 2589: 2587: 2582: 2581: 2578: 2565: 2562: 2558: 2557: 2553: 2552: 2549: 2545: 2538: 2534: 2533: 2529: 2527: 2523: 2522: 2518: 2516: 2512: 2511: 2507: 2503: 2501: 2497: 2496: 2492: 2488: 2487: 2484: 2479: 2475: 2459: 2458: 2450: 2448: 2446: 2437: 2433: 2428: 2423: 2419: 2415: 2411: 2404: 2395: 2387: 2381: 2377: 2373: 2372: 2367: 2361: 2359: 2350: 2344: 2340: 2333: 2325: 2319: 2315: 2308: 2300: 2298:1-84415-026-7 2294: 2290: 2283: 2275: 2269: 2265: 2258: 2243: 2239: 2233: 2225: 2221: 2217: 2213: 2209: 2205: 2201: 2194: 2186: 2182: 2178: 2174: 2169: 2164: 2161:(3): 229–34. 2160: 2156: 2152: 2145: 2137: 2133: 2129: 2125: 2121: 2114: 2106: 2102: 2097: 2092: 2088: 2084: 2080: 2076: 2072: 2065: 2057: 2056: 2051: 2045: 2037: 2033: 2027: 2013:on 2009-05-06 2012: 2008: 2002: 1998: 1994: 1987: 1979: 1975: 1971: 1967: 1963: 1959: 1955: 1951: 1944: 1936: 1932: 1928: 1924: 1920: 1916: 1909: 1901: 1897: 1893: 1886: 1878: 1874: 1869: 1864: 1860: 1856: 1852: 1845: 1843: 1834: 1830: 1825: 1820: 1817:(6): 1538–9. 1816: 1812: 1808: 1801: 1793: 1789: 1784: 1779: 1775: 1771: 1767: 1763: 1759: 1752: 1744: 1740: 1736: 1732: 1728: 1724: 1720: 1716: 1709: 1701: 1697: 1692: 1687: 1683: 1679: 1675: 1671: 1667: 1660: 1652: 1648: 1643: 1638: 1634: 1630: 1626: 1622: 1618: 1614: 1610: 1603: 1595: 1591: 1586: 1581: 1577: 1573: 1569: 1567: 1558: 1550: 1546: 1542: 1538: 1534: 1530: 1526: 1522: 1514: 1506: 1502: 1497: 1492: 1488: 1484: 1481:(10): 3465–. 1480: 1476: 1472: 1465: 1457: 1453: 1448: 1443: 1439: 1435: 1431: 1424: 1416: 1412: 1407: 1402: 1398: 1394: 1390: 1383: 1375: 1371: 1367: 1363: 1356: 1348: 1344: 1340: 1336: 1332: 1328: 1324: 1320: 1313: 1305: 1301: 1297: 1293: 1289: 1285: 1281: 1274: 1266: 1262: 1257: 1252: 1248: 1244: 1240: 1233: 1225: 1221: 1217: 1213: 1209: 1205: 1198: 1190: 1186: 1181: 1176: 1172: 1168: 1165:(6): 1128–l. 1164: 1160: 1156: 1149: 1141: 1137: 1133: 1129: 1125: 1121: 1118:(3): 568–73. 1117: 1113: 1106: 1098: 1094: 1090: 1086: 1082: 1078: 1071: 1069: 1067: 1058: 1054: 1049: 1044: 1040: 1036: 1033:(3): 368–70. 1032: 1028: 1024: 1017: 1015: 1006: 1002: 998: 994: 990: 987:(2): 148–50. 986: 982: 978: 971: 963: 959: 955: 951: 947: 943: 939: 935: 928: 920: 916: 912: 908: 904: 900: 896: 892: 885: 877: 873: 869: 865: 861: 857: 854:(4): 363–70. 853: 849: 841: 833: 829: 824: 819: 815: 811: 808:(2): 256–62. 807: 803: 799: 792: 785: 781: 778: 773: 765: 761: 756: 751: 747: 743: 739: 732: 724: 720: 715: 710: 706: 702: 698: 694: 690: 683: 675: 671: 667: 663: 659: 655: 651: 647: 646:J Med Entomol 643: 636: 628: 624: 619: 614: 609: 604: 600: 596: 592: 585: 578: 573: 571: 562: 558: 554: 550: 546: 542: 538: 534: 527: 519: 512: 508: 498: 495: 494: 488: 486: 480: 478: 473: 471: 467: 462: 458: 454: 450: 446: 442: 438: 433: 431: 430:Burma theatre 427: 423: 419: 415: 407: 404:photographer 403: 402: 397: 392: 383: 381: 377: 373: 370: 366: 361: 358: 354: 350: 346: 341: 333: 331: 327: 323: 322:Ciprofloxacin 319: 315: 311: 307: 303: 298: 290: 288: 283: 281: 277: 272: 270: 265: 261: 257: 253: 243: 239: 235: 233: 229: 228: 222: 220: 216: 215: 210: 200: 198: 194: 190: 186: 182: 178: 174: 170: 166: 162: 158: 154: 150: 146: 142: 132: 130: 129: 124: 123: 119: 115: 111: 106: 104: 101: 97: 94: 93:Gram-negative 90: 89: 85: 81: 78:is a form of 77: 73: 65: 62: 60: 56: 53: 52: 47: 43: 38: 34: 30: 25: 19: 5110:Malakoplakia 5036:Folliculitis 4960:Unspecified 4932:Lyme disease 4869:Helicobacter 4868: 4843: 4792: 4779: 4766: 4723: 4704:Gonococcemia 4615: 4595:Trench fever 4575:Scrub typhus 4574: 4515: 4436: 4428: 4420: 4380:Buruli ulcer 4349: 4324: 4294:Gas gangrene 4283: 4267: 4241: 4214: 4184: 4109:Helicobacter 4108: 4100: 4086:Peptic ulcer 4078: 4060: 4025: 4013: 3986: 3966: 3946: 3939: 3930: 3922: 3902: 3895: 3888: 3881: 3867: 3860:Vibrionaceae 3840: 3813: 3795: 3762: 3742: 3726: 3706: 3692: 3678: 3670: 3658: 3621: 3607: 3589: 3582: 3576: 3546: 3513: 3484: 3478: 3469: 3461: 3437: 3397: 3388: 3374: 3356: 3297: 3290: 3276: 3262: 3231: 3217: 3211: 3202: 3182: 3147: 3131:Neisseriales 3090: 3078: 3074: 3067:Trench fever 3059: 3045: 3014: 3007:Brucellaceae 2974: 2960: 2954:Anaplasmosis 2942: 2939:Ehrlichiosis 2903: 2884:Scrub typhus 2883: 2876: 2862: 2840: 2832: 2818: 2804: 2790: 2776: 2762: 2748: 2734: 2720: 2674: 2660: 2609:-associated 2554: 2530: 2519: 2504: 2489: 2455: 2420:(2): 162–5. 2417: 2413: 2403: 2394: 2370: 2338: 2332: 2313: 2307: 2288: 2282: 2263: 2257: 2246:. 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Retrieved 2011:the original 1996: 1986: 1953: 1949: 1943: 1921:(5): 570–2. 1918: 1914: 1908: 1899: 1895: 1885: 1861:(5): 955–9. 1858: 1854: 1814: 1810: 1800: 1765: 1761: 1751: 1721:(9): 947–9. 1718: 1714: 1708: 1673: 1669: 1659: 1616: 1612: 1602: 1575: 1571: 1565: 1557: 1524: 1520: 1513: 1478: 1474: 1464: 1437: 1433: 1423: 1396: 1392: 1382: 1368:(3): 580–3. 1365: 1361: 1355: 1322: 1318: 1312: 1290:(5): 556–9. 1287: 1283: 1279: 1273: 1246: 1242: 1232: 1210:(2): 400–6. 1207: 1203: 1197: 1162: 1158: 1148: 1115: 1111: 1105: 1083:(4): 425–8. 1080: 1076: 1030: 1026: 1005:the original 984: 980: 970: 962:the original 944:(6): 404–5. 941: 937: 927: 919:the original 901:(3): 207–8. 898: 894: 884: 851: 847: 840: 805: 801: 791: 772: 748:(1): 11–21. 745: 741: 731: 696: 692: 682: 649: 645: 641: 635: 598: 594: 584: 536: 532: 526: 517: 511: 481: 474: 461:Kokoda Track 434: 422:World War II 411: 399: 374: 368: 362: 342: 339: 318:azithromycin 306:tetracycline 299: 296: 284: 273: 252:dengue fever 249: 240: 236: 225: 223: 212: 206: 189:encephalitis 173:splenomegaly 161:hemorrhaging 156: 138: 126: 120: 107: 86: 75: 72:Scrub typhus 71: 70: 49: 27:Scrub typhus 18: 5115:Pyomyositis 4823:Shigellosis 4793:Pseudomonas 4717:Melioidosis 4683:Oroya fever 4673:Brucellosis 4505:Nocardiosis 4315:Listeriosis 4285:Clostridium 3931:Pseudomonas 3679:Haemophilus 3660:Haemophilus 3615:Yersiniosis 3566:Shigellosis 3270:Melioidosis 3079:B. quintana 3075:B. henselae 3022:Brucellosis 2457:El Mercurio 539:(2): 92–8. 406:George Silk 357:cotton rats 330:miscarriage 326:stillbirths 302:doxycycline 256:paratyphoid 232:Solomon Sea 193:myocarditis 185:Pneumonitis 76:bush typhus 32:Other names 5160:Categories 5003:Paronychia 4998:Cellulitis 4871:cellulitis 4782:cellulitis 4722:Cutaneous 4326:Mycoplasma 4276:Erythrasma 4249:Erysipelas 4240:Cutaneous 4111:cellulitis 3694:H. ducreyi 3681:meningitis 3203:ungrouped: 2896:Flea-borne 2855:Mite-borne 2713:Tick-borne 2532:DiseasesDB 2248:2022-06-21 2130:(1): 1–6. 2017:2008-10-03 503:References 453:New Guinea 314:Rifampicin 181:Leukopenia 159:can cause 122:Rickettsia 4993:Carbuncle 4846:infection 4844:Aeromonas 4838:Chancroid 4762:Tularemia 4726:infection 4708:Gonorrhea 4618:infection 4518:infection 4439:infection 4431:infection 4423:infection 4244:infection 4176:Bacillota 4028:infection 4026:Aeromonas 3933:infection 3848:Tularemia 3700:Chancroid 3472:infection 3454:Slow/weak 3368:Pneumonia 3309:Pertussis 3190:Gonorrhea 2843:infection 2556:eMedicine 1999:. Mosby. 1743:207384950 1633:1469-493X 561:206172576 376:Dora Lush 363:Enormous 293:Treatment 246:Diagnosis 59:Specialty 5176:Zoonoses 5078:Gangrene 5029:Pyoderma 4962:pathogen 4892:Syphilis 4887:Syphilid 4736:Glanders 4541:Gram -ve 4225:Impetigo 4200:Impetigo 4167:Gram +ve 3556:flexneri 3470:Serratia 3284:Glanders 2564:ped/2710 2561:derm/841 2436:12389941 2224:19220144 2185:41165633 2177:10338191 2105:20248030 2075:Br Med J 1978:29646085 1970:11009140 1935:15307429 1877:17123995 1792:10543774 1735:19011809 1700:17638700 1651:30246875 1594:12685633 1549:23316592 1505:18716229 1456:17172374 1415:16968938 1347:24087729 1339:14501995 1265:17205447 1140:44692835 1132:14014756 1057:20207857 1001:18362409 958:17186964 915:16785710 876:25778287 868:16762116 832:16494751 780:Archived 764:11226850 723:27928073 666:11296840 627:29590177 553:18281226 491:See also 468:and the 269:serology 209:chiggers 145:headache 128:Orientia 114:pathogen 5058:Ecthyma 4969:Abscess 4897:Chancre 4813:Q fever 4400:Leprosy 4352:related 3875:Cholera 3821:Q fever 3424:O104:H4 3419:O157:H7 3073:Either 2702:Spotted 2376:297–298 2136:6789455 2096:2053023 1833:9868680 1691:2043199 1642:6485465 1541:8676722 1496:2566087 1374:9185274 1304:8940989 1224:3128129 1189:6809786 1097:9373640 1048:2829893 823:3373100 714:5154431 674:8133110 618:5891077 439:in the 437:Oceania 420:during 386:History 345:vaccine 336:Vaccine 5166:Typhus 5053:Pimple 4828:Plague 4493:Others 4308:Others 3597:Plague 3560:boydii 3552:sonnei 2653:Typhus 2526:D01261 2434:  2382:  2345:  2320:  2295:  2270:  2222:  2183:  2175:  2134:  2103:  2093:  2003:  1976:  1968:  1950:Lancet 1933:  1875:  1831:  1790:  1780:  1741:  1733:  1698:  1688:  1649:  1639:  1631:  1592:  1547:  1539:  1521:Lancet 1503:  1493:  1454:  1413:  1372:  1345:  1337:  1302:  1263:  1222:  1187:  1180:272264 1177:  1138:  1130:  1095:  1055:  1045:  999:  956:  913:  874:  866:  830:  820:  762:  721:  711:  672:  664:  625:  615:  559:  551:  418:Ceylon 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Index


Orientia tsutsugamushi
Specialty
Infectious disease
typhus
intracellular parasite
Orientia tsutsugamushi
Gram-negative
α-proteobacterium
family
Rickettsiaceae
typhus
pathogen
genus
Rickettsia
Orientia
fever
headache
cough
gastrointestinal symptoms
hemorrhaging
intravascular coagulation
eschar
splenomegaly
lymphadenopathies
Leukopenia
Pneumonitis
encephalitis
myocarditis
acute encephalitis syndrome

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