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protects against various infections in different animal models ranging from C. elegans to mouse models, they made an even more striking discovery. They showed that subclinical levels of microbes can rapidly seed (nucleate) amyloid plaques. It has long been held that amyloid plaques require a decade or more to form in the brain. However, injecting either bacteria or virus into the hippocampus of very young AD mice, showed that amyloid plaques formed overnight. These findings suggest that even subclinical levels of bacteria, viruses, or other microbes, entering or activating the brain, may initially trigger plaque formation and start the amyloid cascade rolling. Tanzi is currently carrying out large-scale metagenomic sequencing of post-mortem AD brains, to catalog the microbes that may be initiating amyloid pathology. In 2018, they published back-to-back papers with a group at Mt. Sinai implicating Herpes viruses in triggering plaque pathology in AD. Tanzi and Moir refer to this as the “antimicrobial protection hypothesis” of AD.
487:. In that study, Tanzi reported the first family-based genome-wide association study of AD, which most notably to the identification of the first innate immune AD gene, CD33, which encodes a cell-surface receptor on monocytes and microglia. When first identified as an AD gene, nothing was known about CD33 in the brain or AD pathology. In 2013, Tanzi and his ex-trainee, Ana Griciuc first reported in Neuron that increased expression of CD33 in microglial cells in AD brain and showed that a protective CD33 gene variant was associated with reductions in CD33 expression and Abeta levels in AD brain. Importantly, they showed CD33 inhibits microglial phagocytosis and clearance of Abeta and induces pro-inflammatory cytokine release leading to neuroinflammation. They also elucidated the molecular mechanism by which sialic acid binds to CD33 to induce neuroinflammation.
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definitively show that amyloid plaques directly cause neurofibrillary tangles, something that could not be shown in mouse models of early-onset familial AD gene mutations in APP and the presenilins (owing to differences in mouse and human isoforms of the Tau protein, the principal component of neurofibrillary tangles). This 3-D cell culture model/human brain organoid system of AD has also made drug screening considerably faster and more cost-effective. Most recently, using a modified 3-D human stem cell-derived neural-glial cell AD model, Tanzi has helped develop therapies targeted against neuroinflammation in AD. These include ALZT-OP1 (AZTherapies) targeting microglial activation and neuroinflammation, and a neuroprotective drug combination, called AMX0035 (
573:, induces Abeta generation, apoptosis, and neurodegeneration in the mouse brain and post-operative CSF of patients. This has gradually led to a dramatic reduction in the clinical use of isoflurane in the operating room, especially in elderly patients and Alzheimer's patients. With trainee, Lee Goldstein, Tanzi showed how head injury due to a bomb blast or collision causes rapid induction of tangles and gliosis in mice. Now referred to as the “bobblehead” effect, it has been postulated to be the main cause of the subsequent onset of chronic traumatic encephalopathy in human subjects exposed to repeated concussion and head trauma.
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ACAT1 promotes the palmitoylation of APP dimers in lipid rafts, rendering them more susceptible to beta-secretase cleavage and Abeta production. They are now testing anti-palmitoylation drugs as well as their ACAT1 inhibitors as potential drugs for preventing the axonal release of Abeta and reducing beta-amyloid deposition.
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functions downstream of CD33 and that crosstalk between CD33 and TREM2 involves the neuroinflammation-related IL-1beta/IL-1RN axis cluster. CD33 has now emerged as the primary target for novel drug discovery programs aimed at curbing neuroinflammation, at over a dozen pharmaceutical and biotech companies.
562:, co-founded by Josh Cohen, Justin Klee with Tanzi serving as the founding chair of the Scientific Advisory Board). AMX0035 was successful in a phase 2 clinical trial of ALS and is now under consideration for approval by the FDA, while it is also being tested in a phase 2 clinical trial in AD patients.
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Gusella, James F.; Wexler, Nancy S.; Conneally, P. Michael; Naylor, Susan L.; Anderson, Mary Anne; Tanzi, Rudolph E.; Watkins, Paul C.; Ottina, Kathleen; Wallace, Margaret R.; Sakaguchi, Alan Y.; Young, Anne B.; Shoulson, Ira; Bonilla, Ernesto; Martin, Joseph B.; et al. (Gusella, J., Wexler, N.,
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In another set of groundbreaking studies, Tanzi, working with Robert Moir, investigated whether amyloid beta (Abeta) may play a normal role in the brain. They demonstrated Abeta to be a potent antimicrobial peptide (AMP) in the brain's innate immune system. After showing that the beta-amyloid protein
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In 1995, Tanzi collaborated with Peter Hyslop and Jerry
Schellenberg to discover the two other EO-FAD genes, presenilin 1 and 2 (PSEN1 and PSEN2). He has published many key studies characterizing the role of the EO-FAD genes in health and disease. All three genes remain among the most highly studied
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Tanzi, RE; Petrukhin, K; Chernov, I; Pellequer, JL; Wasco, W; Ross, B; Romano, DM; Brzustowicz, LM; Devoto, M; Peppercorn, J; Bush, AI; Sternlieb, I; Pirastu, M; Gusella, JF; Evgrafov, O; Penchaszadeh, GK; Honig, B; Edelman, IS; Soares, MB; Scheinberg, IH; Gilliam, TC (1993). "Identification of the
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the existence of auto-antibodies against oligomeric Abeta, which they showed to protect against risk for AD. This discovery inspired Roger Nitsch and the Swiss biotech, Neurimmune to develop an AD therapy based on isolating those auto-antibodies from memory B-cells and reverse translating them into
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Also in 2000, Tanzi collaborated with cell biologist, Dora Kovacs, to show that blocking the enzyme acetyl-coA acetyltransferase 1 (ACAT1), responsible for storing cholesterol as lipid droplets in intracellular rafts, prevents the generation of Abeta. Most recently, this led to their discovery that
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list. In 2015, Tanzi also received the
Smithsonian American Ingenuity Award, the nation's highest award for invention and innovation. He also received the Silver Innovator Award, the Brain Research Foundation Award, the Ronald Reagan Award, the Pew Scholar Award, the Nathan Shock Award, the Rustum
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between 1987 and 1988, describing the initial cloning, mapping, and characterization of the gene encoding the amyloid beta-protein precursor (APP). Two other groups reported the cloning of APP at that time, and the gene was shown in 1990 to contain a mutation causing Dutch cerebral hemorrhage with
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Levy-Lahad, E; Wasco, W; Poorkaj, P; Romano, DM; Oshima Jm, Pettingell WH; Yu, C; Jondro, PD; Schmidt, SD; Wang, K; Crowley, AC; Fu, Y-H; Guenette, SY; Galas, D; Nemens, E; Wijsman, EM; Bird, TD; Schellenberg, GD; Tanzi, RE (1995). "Candidate gene for the chromosome 1 familial
Alzheimer's disease
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Tanzi has testified to
Congress on both Alzheimer's disease and most recently, in September 2019, on maintaining brain health. Tanzi serves on dozens of editorial and scientific advisory boards and as chair of the Cure Alzheimer's Fund Research Leadership Group. He has published over 600 research
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with his post-doctoral fellow Ashley Bush, Tanzi demonstrated a key role for zinc, copper, and iron in beta-amyloid deposition and Lewy body formation. This finding has led to the initiation of AD clinical trials of metal chaperones targeting metal-induced aggregation of beta-amyloid in AD and of
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in 2019, Tanzi and
Griciuc compared the neuroinflammatory effects of the CD33 gene to another AD-associated innate immune gene, TREM2. Knockout of CD33 in AD mice attenuated amyloid-beta pathology and improved cognition while knockout of TREM2 led to opposite effects. They then showed that TREM2
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2020: Used multiple whole genome sequencing datasets for the first time to identify sex-specific genetic risk factors for AD (ZBTB7C, GRID1, RIOK3, MCPH1) as well as several novel
Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development (FNBP1L,
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In 2000, Tanzi and Steven Wagner began screening for a class of drugs that they termed "gamma secretase modulators (GSM)". GSM's reverse the Abeta42:Abeta40 ratio and thereby prevent the “seeding” of amyloid plaques. Notably, they do not inhibit gamma-secretase. Tanzi and Wagner have published
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as “Alzheimer's-in-a-Dish”. This model was the first to recapitulate all three key AD pathological hallmarks in vitro, and, most importantly, resolved a decades-long debate as to whether Abeta pathology causes the formation of neurofibrillary tangles. Using this system, they were the first to
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2014: Invented a 3D human stem cell-derived neural culture AD model that recapitulated for the first time, plaques and tangles in vitro. This was the first model to definitively show that ?? amyloid plaques induce bona fide neurofibrillary tangles from endogenous
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2018: Invented a new 3D human stem cell-derived mixed neural-astrocyte-microglial microfluidic AD model, which showed neuronal Aβ deposition/tangle formation induces microglial activation and synaptic pruning/axotomy beginning with the astrocytic release of
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Gusella, JF; Wexler, NS; Conneally, PM; Naylor, SL; Anderson, MA; Tanzi, RE; Watkins, PC; Ottina, K; Wallace, MR; Sakaguchi, AY; Young, AB; Shoulson, I; Bonilla, E; Martin, JB (1983). "A polymorphic DNA marker genetically linked to
Huntington's Disease".
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Tanzi, RE; Gusella, JF; Watkins, PC; Bruns, GAP; St; George-Hyslop, PH; Van Keuren, ML; Patterson, D; Pagan, S; Kurnit, DM; Neve, RL. (1987). "The amyloid beta protein gene: cDNA cloning, mRNA distribution, and genetic linkage near the
Alzheimer locus".
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2010: Discovered the first non-NSAID class of gamma secretase modulators (GSM), which selectively lower production of Aβ42 without off-target effects of gamma secretase inhibitors. A clinical candidate is slated for phase I clinical trials in
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2016: Demonstrated Aβ to be a potent antimicrobial peptide in the brain; showed for the first time in mice and 3D models that microbes can rapidly (overnight) seed deposition of β-amyloid as a defense mechanism of the brain's innate immune
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Bertram, L; Blacker, D; Mullin, K; Keeney, D; Jones, J; Basu, S; Yhu, S; McInnis, M; Go, R; Vekrellis, K; Selkoe, D; Saunders, A; Tanzi, RE (2000). "Evidence for genetic linkage of
Alzheimer's disease to chromosome 10q".
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2022: Used whole-genome sequencing to discover two new genes associated with
Alzheimer's disease: DTNB and DLG2. Discovered that the plasma IL-12/IFN-Îł axis predicts cognitive trajectories in cognitively unimpaired older
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Bertram, L; Hiltunen, M; Parkinson, M; Ingelsson, M; Lange, C; Ramasamy, K; Mullin, K; Menon, R; Sampson, AJ; Hsiao, MY; Elliott, KJ; Moscarillo, T; Hyman, BT; Wagner, SL; Becker, KD; Blacker, D; Tanzi, RE (2005).
363:. His team was the first to use human stem cells to create three-dimensional cell culture organoids of AD, dubbed “Alzheimer's-in-a-Dish”. The 3-D model made drug screening for AD faster and more cost-effective.
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Choi, SH; Kim, YH; Hebisch, M; Sliwinski, C; Lee, S; D'Avanzo, C; Chen, J; Hooli, B; Asselin, C; Muffat, J; Klee, JB; Zhang, C; Wainger, BJ; Peitz, M; Kovacs, DM; Woolf, CJ; Wagner, SL; Tanzi, RE; Kim, DY (2014).
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Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY (November 13, 2014).
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2018: Demonstrated the key role of exercise-induced hippocampal neurogenesis in ameliorating AD pathology in AD transgenic mice and successfully mimicked this effect pharmacologically and genetically.
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2021: Showed astrocytic interleukin-3 programs microglia and reduces neuroinflammation in Alzheimer's disease. Co-authored successful clinical trial in ALS leading to approval of Relyvrio (Amylyx).
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drug targets in the field of AD, especially about therapeutic strategies aimed at reducing beta-amyloid deposition. In 1993, Tanzi also first discovered the gene for the neurodegenerative disease,
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Other AD genes Tanzi has discovered include ADAM10, UBQLN1, IDE, A2M, ITGB3, and ATXN1. In 2019, Tanzi, his ex-trainee, Jaehong Suh, and Huda Zoghbi (Baylor) led a study published in the journal,
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Tanzi, RE; McClatchey, AI; Lamperti, ED; V-Komaroff, L; Gusella, JF; Neve, R (1988). "Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease".
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506:, showing that ATXN1 (encoding the spinal cerebellar ataxia gene product, Ataxin-1) controls the production of the amyloid beta protein by regulating the expression of the gene BACE1.
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amyloidosis and later in 1991, a mutation causing early-onset familial AD (EO-FAD). In 1992, Tanzi and ex-trainee, Wilma Wasco, discovered the two APP family members, APLP1 and APLP2.
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In 2018, Tanzi was inducted into the Rhode Island Heritage Hall of Fame. He was also inducted into the Cranston Hall of Fame in 2000. Tanzi was awarded an honorary doctorate from
778:. He was included on the list of the "Harvard 100 Most Influential Alumni", and was chosen by the Geoffrey Beene Foundation as a “Rock Star of Science”. In 2015, he was named by
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2008: Employed family-based GWAS to discover the AD gene, CD33, the first AD gene controlling neuroinflammation and innate immunity in the brain, now a major drug target for AD.
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In 2014, Tanzi, and his ex-trainees, Doo Yeon Kim and Se Hoon Choi, were the first to use human stem cells to create three-dimensional cell culture organoids of AD, dubbed by
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In other studies, Tanzi and his trainee, Zhongcong Xie, published several seminal papers providing the first evidence that the widely used general inhalant anesthetic,
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Bertram, L; McQueen, MB; Mullin, K; Blacker, D; Tanzi, RE (2007). "Systematic Meta-Analyses of Alzheimer's Disease Genetic Association Studies: The AlzGene Database".
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papers and has been issued numerous patents. He has co-authored three international bestsellers with Deepak Chopra. Tanzi has hosted three shows on public television:
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2019: Demonstrated that ataxin-1, the gene causing spinal cerebellar ataxia, regulates the production of amyloid beta by controlling the expression of the BACE1 gene.
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1984-1988: Was among the first to discover the amyloid precursor protein (APP) gene and map it to chromosome 21, for which he produced the first complete linkage map.
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2008: Showed first evidence that isoflurane (a general anesthetic) induces Aβ generation and neurodegeneration, leading to a dramatic reduction in its clinical use.
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2010: Discovered and validated the first highly penetrant late-onset AD mutations in ADAM10, the main alpha-secretase that precludes Aβ production in the brain.
750:. He also co-wrote the tribute song to Alzheimer's patients called "Remember Me", performed by singer Chris Mann. He plays keyboards on the albums: Aerosmith:
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Tanzi, R. E.; Petrukhin, K.; Chernov, I.; Pellequer, J. L.; Wasco, W.; Ross, B.; Romano, D. M.; Parano, E.; Pavone, L.; Brzustowicz, L. M. (December 1993).
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2005: Showed auto-antibodies to oligomeric Aβ protect against AD – acknowledged to have significantly influenced the promising AD immunotherapy, Aducanumab.
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1993: Carried out physical mapping of chromosome 21 to show SOD1 as the first gene causing familial amyotrophic lateral sclerosis with Bob Brown (U. Mass.).
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340:, vice-chair of neurology, director of the Genetics and Aging Research Unit, and co-director of the Henry and Allison McCance Center for Brain Health at
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Over the past two decades, Tanzi has also contributed to the development of novel therapeutics for AD. Beginning in 1994, in a study published in
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Tanzi RE, Gusella JF, Watkins PC, Bruns GA, St George-Hyslop P, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL (February 20, 1987).
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Rosen, DR; Siddique, T; Patterson, D; Figlewicz, DA; Sapp, P; Hentati, A; Donaldson, D; Goto, J; O'Regan, JP; Deng, HX; et al. (1993).
481:'s Alzheimer's Genome Project, Tanzi several other AD genes, most notably, CD33, reported in 2008 with his ex-trainee, Lars Bertram, in the
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Kumar, D; Choi, SH; Washicosky, KJ; Eimer, WA; Tucker, S; Ghofrani, J; Lefkowitz, A; McColl, G; Goldstein, LE; Tanzi, RE; Moir, RD (2016).
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Griciuc, A; Serrano-Pozo, A; Parrado, AR; Lesinski, AN; Asselin, CN; Mullin, K; Hooli, B; Choi, SH; Hyman, BT; Tanzi, RE (2013).
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2010: Zinc-copper chelator, PBT2 (from Prana Biotechnology, now Alterity Therapeutics) successful in a phase 2 AD clinical trial.
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Super brain: unleashing the explosive power of your mind to maximize health, happiness, and spiritual well-being (Book, 2012)
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In 1987, based on his doctoral studies at Harvard Medical School, he was the lead author of seven papers published in
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2000: Discovered genetic linkage of AD to chromosome 10, implicating the gene encoding the insulin-degrading enzyme.
698:” effect of head injury/concussion causes tangle and gliosis pathology leading to chronic traumatic encephalopathy.
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2001: Showed that AD pathology in transgenic mice could be ameliorated by a zinc-copper chelator, clioquinol (PBT1)
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Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being.
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1995: Cloned and discovered first mutations in AD gene presenilin 2; collaborated on the cloning of presenilin 1.
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1442:"Alzheimer's Disease-Associated b-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection"
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The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life (Book, 2018)
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Tanzi has received numerous awards, including the two highest awards for Alzheimer's disease research: The
1356:"Amyloid-BetaPeptide Protects Against Microbial Infection In Mouse and Worm Models of Alzheimer's Disease"
470:. In that same year, he contributed to the discovery of the first familial amyotrophic lateral sclerosis (
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He has published over 600 research papers and has received the highest awards in his field, including the
847:"Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis"
1259:"ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function"
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SEL1L, LINC00298, PRKCH, C15ORF41, C2CD3, KIF2A, APC, LHX9, NALCN, CTNNA2, SYTL3, CLSTN2, DTNB, DLG2).
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1853:"Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus"
1591:"The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene"
1399:"Neuron-Glia Interactions Recapitulated in a 3D Organotypic Human Alzheimer's Disease Brain Model"
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Wilson's disease gene: A copper transporting ATPase with homology to the Menke's disease gene".
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The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life.
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2010: Demonstrated Aβ to be a potent antimicrobial peptide in the brain's innate immune system.
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Decoding darkness : the search for the genetic causes of Alzheimer's disease (Book, 2000)
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2018: Showed that the amyloid beta protein protects the brain against herpes virus infection.
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Park, J; Wetzel, I; Marriott, I; Dréau, D; D'Avanzo, C; Kim, D-Y; Tanzi, RE; Cho, H (2018).
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several papers on these compounds. Their ongoing drug development efforts supported by the
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and generally accepted as the central driver of the disease. The results were published in
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1993: Carried out chromosome 21 physical mapping leading to first familial ALS gene-SOD1.
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Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being.
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Suh, J; Choi, SH; Romano, DM; Gannon, MA; Lesinski, AN; Kim, DY; Tanzi, RE (2013).
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1999: Mapped the BACE2 gene to the obligate Down Syndrome region of chromosome 21
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It may require cleanup to comply with Knowledge's content policies, particularly
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2013: Showed that CD33 controls neuroinflammation in AD at the microglial level.
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At the start of his career in 1980, Tanzi worked as a research technologist for
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1214:"Alzheimer's Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta"
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1983: Helped localize the Huntington's disease gene via genetic linkage (with
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1142:"Family-based association between Alzheimer's disease and variants in UBQLN1"
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1647:"A three-dimensional human neural cell culture model of Alzheimer's disease"
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Eimer, WA; Kumar, D; Kumar, N; Breakefield, XO; Tanzi, RE; Moir, RD (2018).
1305:"A three-dimensional human neural cell culture model of Alzheimer's disease"
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Decoding Darkness: The Search for the Genetic Causes of Alzheimer's Disease.
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2007: Established widely used gene databases: AlzGene, PDGene and SZGene.
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386:. Tanzi received his B.S. in microbiology and B.A. in history from the
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2003: Clioquinol (PBT1) was successful in a phase 2 AD clinical trial.
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1529:"A polymorphic DNA marker genetically linked to Huntington's disease"
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Metlife Foundation Award for Medical Research in Alzheimer's Disease
589:. Tanzi regularly appears on network television programs, including
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In musical pursuits, Tanzi serves as a studio keyboard player for
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1994: Showed zinc/copper drives Aβ aggregation and neurotoxicity.
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since the 1980s. He co-discovered all three familial early-onset
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with Deepak Chopra. New York: Harmony Books, Random House, 2012.
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1934:"Chris Mann - Remember Me (An Anthem for Alzheimer's Disease)"
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from the article and its talk page, especially if potentially
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1909:"Forging a better connection between the brain and the mind"
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was on the discovery and isolation of the gene that encodes
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2007:"Rudolph E. Tanzi, Ph.D. | Mass General Research Institute"
1983:"Rudolph E. Tanzi, Ph.D. | Mass General Research Institute"
1749:"Rudolph E. Tanzi, Ph.D. | Mass General Research Institute"
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in 1980. In 1990, he received his Ph.D. in neurobiology at
370:. Tanzi on occasion serves as a studio keyboard player for
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with Deepak Chopra. New York: Harmony, Random House, 2018.
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with Deepak Chopra. London: Rider, Ebury Publishing, 2015.
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alpha-synuclein and Lewy bodies in Parkinson's disease.
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with Ann B, Parson. New York: Perseus Publishing, 2000.
758:. He has also performed with the legendary opera star,
2032:"Brain scientist "rock star" to address class of 2015"
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In 2005, Tanzi and his ex-trainee and late colleague,
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A major contributor to this article appears to have a
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Official Web page at Massachusetts General Hospital
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2011:Find a Researcher - Massachusetts General Hospital
1987:Find a Researcher - Massachusetts General Hospital
1753:Find a Researcher - Massachusetts General Hospital
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1774:"Gene hunter by day, Aerosmith organist by night"
694:2012: With Lee Goldstein, first showed that the “
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2103:Super Genes: The hidden key to total well-being
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792:Roy Award, and the Oneness in Humanity Award.
666:2005: Discovered ubiquitin 1 to be an AD gene.
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2034:. University of Rhode Island. Archived from
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1703:: CS1 maint: multiple names: authors list (
522:Neurotherapeutics Blueprint Program and the
2228:Members of the National Academy of Medicine
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639:1993: Discovered the Wilson's disease gene.
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53:Learn how and when to remove these messages
1959:"Curing Alzheimer's with Science and Song"
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544:the promising beta-amyloid immunotherapy,
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1800:Tanzi RE, Bertram L (February 25, 2005).
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332:(born September 18, 1958) a professor of
309:Learn how and when to remove this message
291:Learn how and when to remove this message
234:Learn how and when to remove this message
168:Learn how and when to remove this message
1925:
1844:
1503:"Alzheimer's Expert Jams with Aerosmith"
1500:
802:
320:
2101:Chopra, Deepak; Tanzi, Rudolph (2015).
1957:Tanzi, Rudy; Mann, Chris (2017-03-03).
1720:"Human Cells Model Alzheimer's Disease"
1637:
432:. There, he assisted in localizing the
2180:
1717:
195:contains content that is written like
1906:
436:gene; his findings were published in
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406:which is a pathological hallmark of
245:
179:
59:
18:
13:
1718:Torgan, Carol (November 3, 2014).
490:In a follow-up study published in
484:American Journal of Human Genetics
14:
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2029:
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464:; his findings were published in
347:Tanzi has been investigating the
34:This article has multiple issues.
1508:Drug Discovery & Development
587:The Brain, Body, Mind Connection
271:. Please discuss further on the
250:
184:
64:
23:
2208:Alzheimer's disease researchers
2117:
2072:
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2023:
1999:
1975:
1772:Christensen, Jen (2013-06-07).
1501:Fletcher, Bevin (26 Jun 2015).
789:Influential People in the World
540:Journal of Biological Chemistry
42:or discuss these issues on the
2223:University of Rochester alumni
1765:
1741:
1582:
1527:Conneally, P., et al) (1983).
1519:
797:The University of Rhode Island
430:Massachusetts General Hospital
342:Massachusetts General Hospital
1:
2213:Harvard Medical School alumni
2163:Official Web page at Harvard
1907:Nanos, Janelle (2017-10-13).
1728:National Institutes of Health
1485:
1124:10.1126/science.290.5500.2302
754:by Aerosmith and Joe Perry's
520:National Institutes of Health
1459:10.1016/j.neuron.2018.06.030
1372:10.1126/scitranslmed.aaf1059
1276:10.1016/j.neuron.2013.08.035
1231:10.1016/j.neuron.2013.04.014
752:Music from Another Dimension
75:biography of a living person
7:
838:
579:Super Brain with Rudy Tanzi
102:must be removed immediately
10:
2244:
2193:Harvard University faculty
1821:10.1016/j.cell.2005.02.008
621:Summary of key discoveries
330:Rudolph Emile 'Rudy' Tanzi
2113:– via worldcat.org.
1932:Chris Mann (2015-01-22).
1415:10.1038/s41593-018-0175-4
419:
400:amyloid precursor protein
807:
737:
378:Early life and education
1879:10.1126/science.2949367
1078:10.1126/science.7638622
957:10.1126/science.2949367
388:University of Rochester
583:Super Genes with Tanzi
392:Harvard Medical School
384:Cranston, Rhode Island
326:
89:Please help by adding
2203:American neurologists
2158:URI Commencement 2015
2144:– via WorldCat.
803:Selected publications
756:Switzerland Manifesto
524:Cure Alzheimer's Fund
479:Cure Alzheimer's Fund
477:As the leader of the
382:Tanzi is a native of
374:and other musicians.
324:
269:neutral point of view
216:neutral point of view
2198:American geneticists
2173:Piano Music by Tanzi
1724:NIH Research Matters
1159:10.1056/nejmoa042765
434:Huntington's disease
95:Contentious material
1871:1987Sci...235..880T
1673:10.1038/nature13800
1665:2014Natur.515..274C
1545:1983Natur.306..234G
1403:Nature Neuroscience
1329:10.1038/nature13800
1321:2014Natur.515..274C
1116:2000Sci...290.2302B
1110:(5500): 2302–2303.
1070:1995Sci...269..973L
986:1988Natur.331..528T
949:1987Sci...235..880T
903:1983Natur.306..234G
863:1993Natur.364..362R
408:Alzheimer's disease
402:, the precursor to
357:Alzheimer's disease
208:promotional content
16:American geneticist
1607:10.1038/ng1293-344
1032:10.1038/ng1293-344
554:The New York Times
537:, reported in the
338:Harvard University
327:
210:and inappropriate
117:"Rudolph E. Tanzi"
1539:(5940): 234–238.
1064:(5226): 973–977.
980:(6156): 528–530.
943:(4791): 880–884.
897:(5940): 234–238.
799:on May 17, 2015.
766:Awards and honors
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264:with its subject.
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2038:on 11 April 2015
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1515:on 27 June 2015.
1511:. Archived from
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872:10.1038/364362c0
630:and Anne Young).
628:James F. Gusella
604:NBC Nightly News
592:CBS Morning News
462:Wilson's disease
361:Wilson’s disease
351:of neurological
325:Rudolph E. Tanzi
314:
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1177:Nature Genetics
1146:N. Engl. J. Med
1020:Nature Genetics
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2036:the original
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1699:cite journal
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394:, where his
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202:Please help
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84:verification
77:
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36:Please help
33:
2218:1958 births
1733:16 December
696:bobble head
535:Robert Moir
158:August 2020
2182:Categories
2135:1024080343
2111:1001632172
2016:2024-03-30
1992:2024-03-30
1968:2017-10-16
1963:TEDxNatick
1943:2017-10-16
1918:2017-10-16
1783:2023-02-14
1758:2024-03-30
1574:13 January
1486:References
1452:(1): 1–9.
611:, Oz, and
571:isoflurane
546:aducanumab
204:improve it
128:newspapers
39:improve it
2088:810953657
1892:1 January
1838:206559875
1615:1061-4036
748:Aerosmith
744:Joe Perry
442:in 1983.
372:Aerosmith
334:Neurology
273:talk page
80:citations
45:talk page
2066:45226067
1830:15734686
1691:25307057
1478:30001512
1433:29950669
1390:27225182
1347:25307057
1295:24055016
1250:23623698
1197:17192785
1168:15745979
1132:11125142
1094:27296868
1056:locus".
839:Articles
349:genetics
344:(MGH).
281:May 2021
224:May 2021
106:libelous
2030:Staff.
1938:YouTube
1887:2949367
1867:Bibcode
1858:Science
1682:4366007
1661:Bibcode
1623:8298641
1569:4320711
1561:6316146
1541:Bibcode
1469:6075814
1424:6800152
1381:5505565
1338:4366007
1317:Bibcode
1286:4105199
1241:3706457
1112:Bibcode
1104:Science
1086:7638622
1066:Bibcode
1058:Science
1040:8298641
1010:4277294
1002:2893290
982:Bibcode
965:2949367
945:Bibcode
937:Science
927:4320711
919:6316146
899:Bibcode
881:8332197
859:Bibcode
784:to the
733:adults.
709:system.
607:, CNN,
511:Science
448:Science
413:Science
353:disease
142:scholar
2133:
2109:
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2042:26 Jun
1885:
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1828:
1689:
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1652:Nature
1631:610188
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1533:Nature
1476:
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1446:Neuron
1431:
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1293:
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1218:Neuron
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1046:
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974:Nature
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851:Nature
585:, and
560:Amylyx
493:Neuron
453:Nature
439:Nature
420:Career
144:
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130:
123:
115:
2140:3 May
1834:S2CID
1627:S2CID
1565:S2CID
1201:S2CID
1090:S2CID
1044:S2CID
1006:S2CID
923:S2CID
808:Books
738:Music
713:MCP1.
685:2021.
609:MSNBC
149:JSTOR
135:books
73:This
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