263:, with the opposite strand serving as a template for the proper sequence for the repair patch. Since multiple proteins are involved in NER, different XP patients may have different gene mutations (called "complementation groups" based on which enzyme is defective in the NER pathway). Ultimately, his group showed that the entire NER pathway could be performed synthetically by reconstituting 30 different purified proteins, allowing him to define DNA repair at the molecular level. Since returning to the United States, his laboratory has focused on the role polymerases play in making ‘emergency’ translesion repairs that lead to additional mutational errors and contribute to cancers.
250:
for their contributions to DNA repair). Working in
Lindahl's lab, Wood developed a way to perform NER on DNA in a test tube using crude cell-free extracts from tissues. By performing this test on extracts derived from blood cells of children with XP, Wood could begin deciphering which different
251:
proteins are involved in the NER process. Extracts from group A XP cells, for example, could be “complemented” to resume DNA repair by adding cellular extracts obtained from group C XP patients (who have a normal group A protein but a non-functional group C protein).
254:
Wood established his own group at ICRF and over the next decade, performed a series of biochemistry experiments to understand each step in the repair process by adding individual, purified proteins. Repair (particularly of UV-induced
259:) includes recognition of the damaged site (probably by sensing an unpaired bubble at the mutation site), nicking the DNA at upstream and downstream sites, excising the damaged DNA, then filling in the single-stranded DNA gap using a
214:
The NER DNA repair pathway is a complex mechanism that cells use to repair DNA damage caused by ultraviolet sun exposure. The pathway is essential to life, and children born with mutations in genes coding for NER proteins develop
835:
Aboussekhra, Abdelilah; Biggerstaff, Maureen; Shivji, Mahmud K.K; Vilpo, Juhani A.; Moncollin, Vincent; Podust, Vladimir N.; Protić, Miroslava; Hübscher, Ulrich; Egly, Jean-Marc; Wood, Richard D. (1995).
520:
Aboussekhra, Abdelilah; Biggerstaff, Maureen; Shivji, Mahmud K.K; Vilpo, Juhani A; Moncollin, Vincent; Podust, Vladimir N; Protić, Miroslava; Hübscher, Ulrich; Egly, Jean-Marc; Wood, Richard D (1995).
1343:
1313:
1021:
563:"Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK"
80:
91:
1308:
203:(NER), particularly for reconstituting the minimum set of proteins involved in this process, identifying proliferating cell nuclear antigen (
1348:
1328:
406:
743:
Wood, RD; Robins, P; Lindahl, T (1988). "Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts".
227:
and must be continuously protected from sunlight to prevent fatal skin scarring and cancers. By the 1980s, scientists (notably
1318:
323:
1333:
1323:
85:
971:
176:
788:"Complementation of DNA repair in xeroderma pigmentosum group A cell extracts by a protein with affinity for damaged DNA"
275:
1004:
290:
132:
54:
1338:
357:
336:
17:
235:
31:
306:
231:) had uncovered how NER works in bacteria but this pathway remained poorly understood in mammalian cells.
1013:
350:
64:
655:"POLN, a Nuclear PolA Family DNA Polymerase Homologous to the DNA Cross-link Sensitivity Protein Mus308"
1201:
1186:
1152:
1090:
1055:
200:
50:
610:
Shivji, Mahmud K.K. (1992). "Proliferating cell nuclear antigen is required for DNA excision repair".
309:
in 2023. He is a jazz bassist (he was a college roommate of the
Hollywood composer and orchestrator
302:
140:
977:
247:
136:
1303:
1080:
997:
982:
216:
926:
1298:
1267:
1257:
282:
8:
1277:
1236:
1120:
838:"Mammalian DNA nucleotide excision repair reconstituted with purified protein components"
522:"Mammalian DNA nucleotide excision repair reconstituted with purified protein components"
313:) and plays in local bands and together with his wife Enid Wood, a violinist and artist.
294:
267:
1272:
1100:
903:
878:
803:
768:
635:
301:
from 1982 to 1985. He currently is J. Ralph
Meadows Professor in Carcinogenesis at the
128:
812:
787:
720:
695:
587:
562:
381:
1206:
1196:
1142:
990:
908:
859:
854:
837:
817:
760:
756:
725:
676:
627:
623:
592:
543:
538:
521:
502:
256:
220:
188:
654:
639:
1125:
1115:
1040:
898:
890:
849:
807:
799:
772:
752:
715:
707:
666:
619:
582:
574:
533:
494:
147:
498:
1231:
1181:
402:
343:
310:
298:
234:
Wood's first breakthrough came in 1988, after he moved to
England to work at the
124:
75:
70:
1262:
1211:
1191:
1105:
1075:
1070:
1060:
1045:
457:
423:
1292:
1252:
1147:
1137:
1110:
1085:
1017:
385:
239:
162:
1157:
1050:
912:
729:
680:
671:
653:
Marini, Federica; Kim, Nayun; Schuffert, Anthony; Wood, Richard D. (2003).
596:
506:
243:
1170:
1163:
1131:
863:
821:
764:
631:
547:
471:
1226:
1221:
1216:
1095:
1065:
711:
578:
330:
228:
114:
696:"POLQ (Pol θ), a DNA polymerase and DNA‐dependent ATPase in human cells"
440:
286:
260:
208:
192:
110:
441:"Elected Fellows, American Association for the Advancement of Science"
1176:
1035:
894:
786:
Robins, P; Jones, CJ; Biggerstaff, M; Lindahl, T; Wood, RD (1991).
474:. Jacksonville, FL: Environmental Mutagenesis and Genomics Society.
196:
834:
519:
271:
191:) is an American molecular biologist specializing in research on
1012:
219:
or XP. XP patients cannot repair DNA mutations, particularly
207:) as part of the NER complex and identifying mammalian repair
785:
561:
Araújo, SJ; Tirode, F; Coin, F; et al. (February 2000).
947:
278:
204:
460:. Cambridge, Mass: American_Academy of Arts and Sciences.
224:
652:
1344:
University of Texas MD Anderson Cancer Center faculty
485:
Lindahl, T. (1999). "Quality
Control by DNA Repair".
1314:UC Berkeley College of Letters and Science alumni
742:
1290:
560:
426:. Heidelberg: Meyenburg Stiftung. 30 April 2005.
876:
493:(5446). Science 1999:286;1897-1905: 1897–1905.
693:
998:
303:University of Texas MD Anderson Cancer Center
1005:
991:
694:Seki, M.; Marini, F.; Wood, R. D. (2003).
418:
416:
902:
853:
811:
719:
670:
586:
537:
199:. He is known for pioneering studies on
30:For other people named Richard Wood, see
452:
450:
27:American molecular biologist (born 1955)
877:Lange, SS; Takata, K; Wood, RD (2011).
484:
413:
407:European Molecular Biology Organization
397:
395:
324:American Academy of Arts & Sciences
14:
1291:
609:
435:
433:
986:
447:
376:
374:
1309:Westminster University (Utah) alumni
392:
927:"Richard D. Wood, Ph.D.: Professor"
464:
430:
276:Westminster College, Salt Lake City
24:
804:10.1002/j.1460-2075.1991.tb04961.x
424:"Die Preisträger, Meyenburg Prize"
371:
291:University of California, Berkeley
25:
1360:
965:
1349:21st-century American biologists
1329:University of Pittsburgh faculty
978:Richard D. Wood - Google Scholar
940:
919:
870:
828:
779:
736:
687:
659:Journal of Biological Chemistry
646:
603:
358:US National Academy of Sciences
337:Meyenburg Cancer Research Prize
554:
513:
478:
403:"Richard D. Wood EMBO profile"
86:Fellow Am. Acad Arts & Sci
13:
1:
1319:American molecular biologists
499:10.1126/science.286.5446.1897
364:
246:later would receive the 2015
236:Imperial Cancer Research Fund
32:Richard Wood (disambiguation)
1334:Fellows of the Royal Society
1324:American medical researchers
879:"DNA polymerases and cancer"
855:10.1016/0092-8674(95)90289-9
757:10.1016/0092-8674(88)90491-6
624:10.1016/0092-8674(92)90416-A
539:10.1016/0092-8674(95)90289-9
307:National Academy of Sciences
157:Other academic advisors
7:
351:Fellow of the Royal Society
10:
1365:
1056:Richard Dickinson Chambers
305:and was elected to the US
201:nucleotide excision repair
29:
1245:
1028:
443:. Washington, D.C.: AAAS.
316:
172:
168:
156:
146:
120:
106:
99:
60:
46:
39:
248:Nobel Prize in Chemistry
137:University of Pittsburgh
1339:Yale University fellows
948:"Enid A. Wood Fine Art"
700:Nucleic Acids Research
672:10.1074/jbc.M305646200
382:"Richard Wood, Fellow"
356:Elected Member of the
187:(born June 3, 1955 in
458:"Dr. Richard D. Wood"
242:(Lindahl, Sancar and
217:xeroderma pigmentosum
1268:Martin David Kruskal
1258:Walter Jakob Gehring
579:10.1101/gad.14.3.349
1278:Stanley B. Prusiner
1121:Peter B. Kronheimer
665:(34): 32014–32019.
295:postdoctoral fellow
160:Franklin Hutchinson
51:Westminster College
1273:George Andrew Olah
1101:Paul Gordon Jarvis
712:10.1093/nar/gkg814
293:(1981), and was a
266:Wood received his
1286:
1285:
1207:Richard E. Taylor
1197:Bernard Silverman
1143:Richard G. Morris
706:(21): 6117–6126.
257:pyrimidine dimers
221:pyrimidine dimers
189:Boulder, Colorado
182:
181:
148:Doctoral advisors
101:Scientific career
16:(Redirected from
1356:
1132:James R. Maxwell
1126:Philippa Marrack
1116:Philip Kocienski
1041:J. Michael Brady
1007:
1000:
993:
984:
983:
974:Wood Lab webpage
959:
958:
956:
954:
944:
938:
937:
935:
933:
923:
917:
916:
906:
874:
868:
867:
857:
832:
826:
825:
815:
783:
777:
776:
740:
734:
733:
723:
691:
685:
684:
674:
650:
644:
643:
607:
601:
600:
590:
558:
552:
551:
541:
517:
511:
510:
482:
476:
475:
468:
462:
461:
454:
445:
444:
437:
428:
427:
420:
411:
410:
399:
390:
389:
378:
37:
36:
21:
1364:
1363:
1359:
1358:
1357:
1355:
1354:
1353:
1289:
1288:
1287:
1282:
1241:
1232:Richard D. Wood
1182:Giacinto Scoles
1024:
1011:
972:Wood Laboratory
968:
963:
962:
952:
950:
946:
945:
941:
931:
929:
925:
924:
920:
895:10.1038/nrc2998
875:
871:
833:
829:
798:(12): 3913–21.
784:
780:
741:
737:
692:
688:
651:
647:
608:
604:
559:
555:
518:
514:
483:
479:
470:
469:
465:
456:
455:
448:
439:
438:
431:
422:
421:
414:
401:
400:
393:
380:
379:
372:
367:
344:EMBO Membership
319:
311:Geoff Stradling
299:Yale University
185:Richard D. Wood
177:Wood Laboratory
161:
139:
135:
131:
127:
125:Yale University
95:
89:
84:
79:
76:Meyenburg Prize
74:
71:EMBO Membership
68:
53:
47:Alma mater
42:
35:
28:
23:
22:
18:Richard D. Wood
15:
12:
11:
5:
1362:
1352:
1351:
1346:
1341:
1336:
1331:
1326:
1321:
1316:
1311:
1306:
1301:
1284:
1283:
1281:
1280:
1275:
1270:
1265:
1263:Roy J. Glauber
1260:
1255:
1249:
1247:
1243:
1242:
1240:
1239:
1237:Graham C. Wood
1234:
1229:
1224:
1219:
1214:
1212:Neil Trudinger
1209:
1204:
1199:
1194:
1192:Wilson Sibbett
1189:
1184:
1179:
1174:
1171:Alan Rickinson
1167:
1160:
1155:
1153:George Pickett
1150:
1145:
1140:
1135:
1128:
1123:
1118:
1113:
1108:
1106:Charles K. Kao
1103:
1098:
1093:
1088:
1083:
1078:
1076:Richard Fortey
1073:
1071:Laurence Eaves
1068:
1063:
1061:Colin W. Clark
1058:
1053:
1048:
1046:Michael Bulmer
1043:
1038:
1032:
1030:
1026:
1025:
1010:
1009:
1002:
995:
987:
981:
980:
975:
967:
966:External links
964:
961:
960:
939:
918:
883:Nat Rev Cancer
869:
848:(6): 859–868.
827:
778:
735:
686:
645:
618:(2): 367–374.
602:
553:
532:(6): 859–868.
512:
477:
463:
446:
429:
412:
405:. Heidelberg:
391:
369:
368:
366:
363:
362:
361:
354:
347:
340:
334:
327:
318:
315:
180:
179:
174:
170:
169:
166:
165:
158:
154:
153:
150:
144:
143:
122:
118:
117:
108:
104:
103:
97:
96:
62:
58:
57:
48:
44:
43:
40:
26:
9:
6:
4:
3:
2:
1361:
1350:
1347:
1345:
1342:
1340:
1337:
1335:
1332:
1330:
1327:
1325:
1322:
1320:
1317:
1315:
1312:
1310:
1307:
1305:
1304:Living people
1302:
1300:
1297:
1296:
1294:
1279:
1276:
1274:
1271:
1269:
1266:
1264:
1261:
1259:
1256:
1254:
1253:Thomas Eisner
1251:
1250:
1248:
1244:
1238:
1235:
1233:
1230:
1228:
1225:
1223:
1220:
1218:
1215:
1213:
1210:
1208:
1205:
1203:
1202:Richard Sykes
1200:
1198:
1195:
1193:
1190:
1188:
1185:
1183:
1180:
1178:
1175:
1173:
1172:
1168:
1166:
1165:
1161:
1159:
1156:
1154:
1151:
1149:
1148:Chris Perrins
1146:
1144:
1141:
1139:
1138:Tim Mitchison
1136:
1134:
1133:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1111:Barry Keverne
1109:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1086:Douglas Gough
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1033:
1031:
1027:
1023:
1019:
1018:Royal Society
1015:
1008:
1003:
1001:
996:
994:
989:
988:
985:
979:
976:
973:
970:
969:
949:
943:
928:
922:
914:
910:
905:
900:
896:
892:
889:(2): 96–110.
888:
884:
880:
873:
865:
861:
856:
851:
847:
843:
839:
831:
823:
819:
814:
809:
805:
801:
797:
793:
789:
782:
774:
770:
766:
762:
758:
754:
751:(1): 97–106.
750:
746:
739:
731:
727:
722:
717:
713:
709:
705:
701:
697:
690:
682:
678:
673:
668:
664:
660:
656:
649:
641:
637:
633:
629:
625:
621:
617:
613:
606:
598:
594:
589:
584:
580:
576:
573:(3): 349–59.
572:
568:
564:
557:
549:
545:
540:
535:
531:
527:
523:
516:
508:
504:
500:
496:
492:
488:
481:
473:
467:
459:
453:
451:
442:
436:
434:
425:
419:
417:
408:
404:
398:
396:
387:
386:Royal Society
383:
377:
375:
370:
359:
355:
352:
348:
345:
341:
338:
335:
332:
328:
325:
321:
320:
314:
312:
308:
304:
300:
296:
292:
288:
284:
280:
277:
273:
269:
264:
262:
258:
252:
249:
245:
241:
240:Tomas Lindahl
237:
232:
230:
226:
222:
218:
212:
210:
206:
202:
198:
194:
190:
186:
178:
175:
171:
167:
164:
163:Tomas Lindahl
159:
155:
152:H. John Burki
151:
149:
145:
142:
138:
134:
130:
126:
123:
119:
116:
112:
109:
105:
102:
98:
93:
90:
87:
82:
77:
72:
66:
63:
59:
56:
52:
49:
45:
38:
33:
19:
1169:
1164:Kenneth Reid
1162:
1158:George Poste
1130:
1081:David Garner
1051:John Burland
951:. Retrieved
942:
930:. Retrieved
921:
886:
882:
872:
845:
841:
830:
795:
792:EMBO Journal
791:
781:
748:
744:
738:
703:
699:
689:
662:
658:
648:
615:
611:
605:
570:
566:
556:
529:
525:
515:
490:
486:
480:
472:"EMGS Award"
466:
281:(1977), his
265:
253:
244:Paul Modrich
233:
223:, caused by
213:
184:
183:
121:Institutions
100:
69:
41:Richard Wood
1299:1955 births
1227:Alan Windle
1222:Simon White
1217:Robin Weiss
1187:James Scott
1096:Julian Jack
1066:David Clary
331:AAAS Fellow
229:Aziz Sancar
209:polymerases
141:MD Anderson
133:UC Berkeley
115:Mutagenesis
81:Fellow AAAS
55:UC Berkeley
1293:Categories
1091:John Hinch
384:. London:
365:References
287:Biophysics
285:degree in
270:degree in
261:polymerase
193:DNA repair
111:DNA Repair
92:EMGS Award
1177:Leo Sachs
1036:Mike Bate
953:14 August
932:13 August
567:Genes Dev
1020:elected
913:21258395
730:14576298
681:12794064
640:12260457
597:10673506
507:10583946
349:Elected
342:Elected
329:Elected
322:Elected
197:mutation
1246:Foreign
1029:Fellows
1022:in 1997
1016:of the
1014:Fellows
904:3739438
864:7697716
822:1935910
773:9810684
765:3349527
632:1348971
548:7697716
487:Science
353:(1997)
289:at the
272:Biology
173:Website
911:
901:
862:
820:
813:453130
810:
771:
763:
728:
721:275456
718:
679:
638:
630:
595:
588:316364
585:
546:
505:
360:(2023)
346:(1998)
339:(1998)
333:(2013)
326:(2018)
317:Awards
107:Fields
94:(2021)
88:(2018)
83:(2013)
78:(1998)
73:(1998)
67:(1997)
61:Awards
769:S2CID
636:S2CID
283:Ph.D.
274:from
238:with
195:and
955:2022
934:2022
909:PMID
860:PMID
842:Cell
818:PMID
761:PMID
745:Cell
726:PMID
677:PMID
628:PMID
612:Cell
593:PMID
544:PMID
526:Cell
503:PMID
279:Utah
268:B.S.
205:PCNA
129:ICRF
899:PMC
891:doi
850:doi
808:PMC
800:doi
753:doi
716:PMC
708:doi
667:doi
663:278
620:doi
583:PMC
575:doi
534:doi
495:doi
491:286
297:at
65:FRS
1295::
907:.
897:.
887:11
885:.
881:.
858:.
846:80
844:.
840:.
816:.
806:.
796:10
794:.
790:.
767:.
759:.
749:53
747:.
724:.
714:.
704:31
702:.
698:.
675:.
661:.
657:.
634:.
626:.
616:69
614:.
591:.
581:.
571:14
569:.
565:.
542:.
530:80
528:.
524:.
501:.
489:.
449:^
432:^
415:^
394:^
373:^
225:UV
211:.
113:,
1006:e
999:t
992:v
957:.
936:.
915:.
893::
866:.
852::
824:.
802::
775:.
755::
732:.
710::
683:.
669::
642:.
622::
599:.
577::
550:.
536::
509:.
497::
409:.
388:.
34:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.