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In 2010, AIDS Research
Alliance in Los Angeles, California announced that it signed a new licensing agreement with Stanford University, transferring exclusive rights of the technology developed by the Stanford research team. Phase I human
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and a team at the U.S. National Cancer
Institute. Samoan healers use the mamala tree to treat hepatitis. Research indicated that prostratin has potential to be useful in the treatment of
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InChI=1S/C22H30O6/c1-11-6-16-20(26,18(11)25)9-14(10-23)7-15-17-19(4,5)21(17,28-13(3)24)8-12(2)22(15,16)27/h6-7,12,15-17,23,26-27H,8-10H2,1-5H3/t12-,15+,16-,17-,20-,21+,22-/m1/s1
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InChI=1/C22H30O6/c1-11-6-16-20(26,18(11)25)9-14(10-23)7-15-17-19(4,5)21(17,28-13(3)24)8-12(2)22(15,16)27/h6-7,12,15-17,23,26-27H,8-10H2,1-5H3/t12-,15+,16-,17-,20-,21+,22-/m1/s1
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Prostratin is of interest because of its unique ability to activate latent viral reservoirs, while preventing healthy cells from infection, as well as its discovery through
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486:. Pioneering agreements to protect indigenous intellectual property rights of the Samoan people were established between the Samoan government and the
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517:. This practical synthesis produces gram quantities of prostratin, and is a major step forward in pharmaceutical development of prostratin.
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Wang, Man-Tzu; Holderfield, Matthew; Galeas, Jacqueline; Delrosario, Reyno; To, Minh D.; Balmain, Allan; McCormick, Frank (2015).
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490:, with 20% of ARA's profits to be returned to the Samoan people, and between the Samoan Government and the
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Press
Release-AIDS Research Alliance Gains Exclusive Rights To New Technology from Stanford University
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69:)-4a,7b-Dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9a
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619:"Practical Synthesis of Prostratin, DPP, and Their Analogs, Adjuvant Leads Against Latent HIV"
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of prostratin will be carried out by the AIDS ReSearch
Alliance in Los Angeles, California.
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and UC Berkeley agreed to share equally in any commercial proceeds from the gene product.
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556:"K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling"
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is trying to isolate the gene sequence responsible for prostratin biosynthesis.
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470:. In 2015, study showed that orally administrated prostratin repressed human
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432:, the antiviral activity of prostratin was discovered during research on the
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416:). While prostratin was originally isolated and identified as a new
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Except where otherwise noted, data are given for materials in their
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U.S. University Shares Drug
Royalties with Samoa for Tree Gene
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Berkeley searches for AIDS cure in a Samoan indigenous tree
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In 2008, a team at
Stanford University led by chemist
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O=C1\C(=C/23(O)(/C=C(/CO)C12O)4(OC(=O)C)(C3C)C4(C)C)C
617:; Jung-Min Kee; Jeffrey M. Warrington (May 2008).
402:activator found in the bark of the mamala tree of
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678:Paul Wender and Stanford Prostratin synthesis
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542:Prostratin and the AIDS Research Alliance
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448:as it could flush viral reservoirs in
273:Key: BOJKFRKNLSCGHY-HXGSDTCMSA-N
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604:, AIDS Research Alliance, 2001-12-13
73:-cyclopropabenzoazulen-9a-yl acetate
509:has published an elegant four-step
283:Key: BOJKFRKNLSCGHY-HXGSDTCMBJ
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13:
492:University of California, Berkeley
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683:Jay Keasling and Prostratin Genes
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693:Prostratin Agreements with Samoa
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357:(at 25 °C , 100 kPa).
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544:, AIDS Research Alliance, 2006
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1:
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573:10.1016/j.cell.2015.10.041
420:from species of the genus
347:390.47 g/mol
82:12-Deoxyphorbol-13-acetate
440:village by ethnobotanist
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595:Prostratin Press Release
643:10.1126/science.1154690
688:Ethnobotanist Paul Cox
488:AIDS Research Alliance
436:of Samoan healers in
434:traditional knowledge
494:where a team led by
37:Preferred IUPAC name
635:2008Sci...320..649W
513:of prostratin from
468:Alzheimer's disease
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511:chemical synthesis
458:As a modulator of
409:Homalanthus nutans
384:Infobox references
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629:(5876): 649–652.
450:latently infected
392:Chemical compound
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226:CompTox Dashboard
129:Interactive image
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320:Chemical formula
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88:Identifiers
80:Other names
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507:Paul Wender
484:ethnobotany
426:Thymelaceae
313:Properties
17:Prostratin
728:Diterpenes
717:Categories
529:References
396:Prostratin
343:Molar mass
214:KO94U6DIQ6
160:ChemSpider
116:3D model (
105:60857-08-1
95:CAS Number
438:Falealupo
430:Australia
661:18451298
598:Archived
582:26590425
478:Overview
652:2704988
631:Bibcode
623:Science
515:phorbol
422:Pimelea
377:what is
375: (
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181:PubChem
659:
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464:cancer
372:verify
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297:SMILES
194:454217
169:399975
140:ChEMBL
31:Names
500:Samoa
428:) in
404:Samoa
398:is a
262:InChI
118:JSmol
657:PMID
578:PMID
560:Cell
466:and
205:UNII
647:PMC
639:doi
627:320
568:doi
564:163
446:HIV
231:EPA
184:CID
65:,9a
57:,7b
53:,7a
49:,4a
45:,1b
41:(1a
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367:N
335:6
333:O
329:H
325:C
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71:H
67:S
63:R
59:R
55:S
51:R
47:S
43:R
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