960:
about 70% following three to five days of dosing at 10 mg daily after a 60-mg loading dose. Platelet aggregation gradually returns to baseline values over five to 9 days after discontinuation of prasugrel, this time course being a reflection of new platelet production rather than pharmacokinetics of prasugrel. Discontinuing clopidogrel 75 mg and initiating prasugrel 10 mg with the next dose resulted in increased inhibition of platelet aggregation, but not greater than that typically produced by a 10-mg maintenance dose of prasugrel alone. Increasing platelet inhibition could increase bleeding risk. The relationship between inhibition of platelet aggregation and clinical activity has not been established.
573:
550:
969:
31:
5117:
40:
947:
and patients with a history of stroke or TIA due to increased risk of bleeding, although several cases have been reported of decreased responsiveness to prasugrel. It has been suggested that the decreased responsiveness observed in prasugrel is likely due to its low but significant frequency of High
Platelet Reactivity (HPR).
959:
to 20 μM or 5 μM ADP, as measured by light transmission aggregometry. Following a 60-mg loading dose of the drug, about 90% of patients had at least 50% inhibition of platelet aggregation by one hour. Maximum platelet inhibition was about 80%. Mean steady-state inhibition of platelet aggregation was
934:
receptors. Prasugrel inhibits platelet aggregation more rapidly, more consistently, and to a greater extent than clopidogrel. The TRITON-TIMI 38 study compared prasugrel with clopidogrel, and showed that prasugrel reduced rates of ischaemic events, but increased bleeding risk. Overall mortality rates
946:
liver enzyme needed to activate clopidogrel may not get the full effect. Tests are available to predict if a patient would be susceptible to this problem or not. Unlike clopidogrel, prasugrel is effective in most individual with the exception in patients over the age of 75, weight under 60 kg,
1785:
Wiviott SD, Trenk D, Frelinger AL, O'Donoghue M, Neumann FJ, Michelson AD, et al. (December 2007). "Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the
Prasugrel in Comparison to Clopidogrel for Inhibition of
815:
Given the risk of bleeding, prasugrel should not be used in people who are older than 75 years, who have low body weight or a history of transient ischemic attacks or strokes. The initiation of prasugrel before coronary angiography outside the context of primary PCI is not recommended.
824:
The drug was introduced to clinical practice in Canada in 2010 but was subsequently withdrawn by the manufacturer in 2020 as a "business decision". This has left a gap in the management of high-risk patients in certain situations in Canada where
Effient was the drug of choice.
1200:
Chew DP, Scott IA, Cullen L, French JK, Briffa TG, Tideman PA, et al. (August 2016). "National Heart
Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the management of acute coronary syndromes 2016".
1624:
O'Donoghue ML, Braunwald E, Antman EM, Murphy SA, Bates ER, Rozenman Y, et al. (September 2009). "Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials".
1735:
Brandt JT, Payne CD, Wiviott SD, Weerakkody G, Farid NA, Small DS, et al. (January 2007). "A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation".
809:), who are planned for treatment with PCI. Prasugrel is associated with a higher bleeding risk compared to clopidogrel but has demonstrated superiority in reducing the composite endpoint of death, recurrent myocardial infarctions and stroke.
3295:
833:
Prasugrel should not be given to people with active pathological bleeding, such as peptic ulcer or a history of transient ischemic attack or stroke, because of higher risk of stroke (thrombotic stroke and intracranial hemorrhage).
1873:
2073:
Rehmel JL, Eckstein JA, Farid NA, Heim JB, Kasper SC, Kurihara A, et al. (April 2006). "Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450".
4700:
4249:
3819:
4229:
4379:
4389:
4349:
4194:
4189:
1952:
Silvano M, Zambon CF, De Rosa G, Plebani M, Pengo V, Napodano M, et al. (February 2011). "A case of resistance to clopidogrel and prasugrel after percutaneous coronary angioplasty".
4204:
3300:
1903:
Ruff CT, Giugliano RP, Antman EM, Murphy SA, Lotan C, Heuer H, et al. (March 2012). "Safety and efficacy of prasugrel compared with clopidogrel in different regions of the world".
4504:
209:
3276:
3986:
3457:
4597:
3809:
4459:
4234:
3991:
766:
Prasugrel was approved for use in the
European Union in February 2009, and in the US in July 2009, for the reduction of thrombotic cardiovascular events (including
4369:
4214:
3784:
3402:
5030:
4274:
164:
3191:
3859:
3839:
645:
5137:
3779:
703:
1843:
5142:
4524:
4103:
2229:
2216:
3244:
1075:
4424:
3944:
3829:
1384:
1461:
4419:
4414:
4239:
4056:
4001:
3522:
3407:
3290:
3285:
4098:
3929:
3924:
3432:
3427:
3422:
3417:
3349:
3344:
2188:
1260:"Reappraisal of thienopyridine pretreatment in patients with non-ST elevation acute coronary syndrome: a systematic review and meta-analysis"
972:
The reaction of prasugrel (top left) to its active metabolite (R-138727, top right). The two structures at the bottom represent the inactive
62:
4834:
4409:
4199:
4108:
3717:
3369:
3324:
659:
4329:
4289:
4209:
4081:
3981:
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2922:
2325:
2320:
4622:
4617:
4607:
4519:
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4484:
4479:
4474:
4469:
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4339:
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4319:
4314:
4309:
4304:
4299:
4294:
4146:
4021:
3996:
3914:
3909:
3904:
3899:
3894:
3864:
3727:
3672:
3617:
3612:
3602:
3597:
3532:
3507:
3384:
3379:
3374:
4399:
4627:
4439:
3667:
3662:
3021:
2259:
1092:
Baker WL, White CM (2009). "Role of prasugrel, a novel P2Y(12) receptor antagonist, in the management of acute coronary syndromes".
4499:
4494:
4394:
4324:
4046:
4041:
4036:
4031:
4026:
3889:
3849:
3657:
3652:
3184:
2351:
687:
InChI=1S/C20H20FNO3S/c1-12(23)25-18-10-14-11-22(9-8-17(14)26-18)19(20(24)13-6-7-13)15-4-2-3-5-16(15)21/h2-5,10,13,19H,6-9,11H2,1H3
4434:
4364:
4113:
4076:
4006:
3824:
1874:"FDA Drug Safety Communication: Reduced effectiveness of Plavix (clopidogrel) in patients who are poor metabolizers of the drug"
4118:
2237:
2117:
1938:
1829:
1771:
1721:
1668:
1610:
1370:
1307:
1244:
1183:
1844:"FDA Announces New Boxed Warning on Plavix: Alerts patients, health care professionals to potential for reduced effectiveness"
4725:
4647:
4584:
3135:
1561:"PPIs Are Not Responsible for Elevating Cardiovascular Risk in Patients on Clopidogrel-A Systematic Review and Meta-Analysis"
3177:
851:
3547:
3527:
775:
5152:
2506:
710:
679:
113:
1000:, which is then converted by CYP3A4 and CYP2B6, and to a minor extent by CYP2C9 and CYP2C19, to a pharmacologically
3152:
2302:
3116:
2524:
2497:
313:
194:
94:
1494:
2908:
2451:
2882:
398:
4354:
2252:
5095:
2735:
1879:
1851:
1847:
1465:
568:
449:
518:
4359:
4259:
2826:
2546:
1258:
Bellemain-Appaix A, Kerneis M, O'Connor SA, Silvain J, Cucherat M, Beygui F, et al. (October 2014).
529:
5107:
4567:
4404:
3804:
1684:"Efficacy and Safety of Proton-Pump Inhibitors in High-Risk Cardiovascular Subsets of the COGENT Trial"
1142:
Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, et al. (November 2007).
349:
2225:
2212:
1469:
942:
from the FDA on 12 March 2010, as the estimated 2–14% of the US population who have low levels of the
2874:
1321:
Montalescot G, Bolognese L, Dudek D, Goldstein P, Hamm C, Tanguay JF, et al. (September 2013).
857:
Central nervous system: Headache (6%), dizziness (4%), fatigue (4%), fever (3%), extremity pain (3%)
545:
5162:
2245:
791:
5167:
5147:
5000:
4950:
3799:
3389:
3319:
3211:
3140:
812:
Prasugrel does not change the risk of death when given to people who have had a STEMI or NSTEMI.
771:
150:
52:
2267:
5172:
5010:
4975:
4960:
4808:
4429:
4244:
3844:
3814:
3762:
3517:
3334:
2489:
2413:
1559:
Demcsák A, Lantos T, Bálint ER, Hartmann P, Vincze Á, Bajor J, et al. (19 November 2018).
1412:"Implications of the Antiplatelet Therapy Gap Left With Discontinuation of Prasugrel in Canada"
272:
498:
5055:
5025:
5005:
4985:
4955:
4254:
4224:
3834:
3794:
3314:
3217:
3017:
2111:
1932:
1823:
1765:
1715:
1682:
Vaduganathan M, Cannon CP, Cryer BL, Liu Y, Hsieh WH, Doros G, et al. (September 2016).
1662:
1604:
1364:
1301:
1238:
1177:
1021:
1005:
891:
798:
760:
736:
438:
389:
345:
5065:
5035:
4980:
4850:
4374:
4279:
4156:
4134:
3874:
3462:
3452:
3079:
2658:
2613:
1049:
956:
458:
282:
8:
5060:
4549:
4344:
4151:
3354:
2469:
894:
to reduce the risk of gastrointestinal bleeding without loss of its antiplatelet effect.
336:
157:
572:
549:
4573:
3757:
3259:
3203:
2760:
2133:"Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog"
2099:
2027:
1996:
1977:
1811:
1650:
1587:
1560:
1438:
1411:
1352:
1284:
1259:
1226:
1117:
1008:
of about 7 hours (range 2 h to 15 h). Healthy subjects, patients with stable
993:
989:
752:
740:
124:
1799:
1638:
4902:
4128:
3004:
2775:
2765:
2755:
2750:
2745:
2720:
2293:
2280:
2272:
2192:
2154:
2091:
2032:
1969:
1920:
1803:
1786:
Platelet
Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial".
1753:
1703:
1654:
1642:
1592:
1541:
1443:
1356:
1344:
1289:
1218:
1165:
1109:
1001:
939:
235:
222:
86:
1981:
1230:
1121:
1105:
378:
5157:
4769:
4758:
3971:
3964:
3934:
3497:
3447:
2978:
2809:
2770:
2740:
2144:
2103:
2083:
2022:
2012:
1961:
1912:
1815:
1795:
1745:
1695:
1634:
1582:
1572:
1531:
1433:
1423:
1334:
1279:
1271:
1210:
1155:
1101:
787:
585:
254:
177:
1323:"Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes"
890:
Prasugrel has a low potential for interactions. It may, for example, be used with
5121:
4715:
4123:
4091:
4066:
3637:
3577:
3339:
3200:
2782:
1916:
1699:
1536:
1519:
1009:
262:
72:
2178:
4802:
4705:
4665:
3627:
3582:
3146:
2673:
2359:
2268:
2182:
1428:
908:
846:
Cardiovascular: Hypertension (8%), hypotension (4%), atrial fibrillation (3%),
756:
748:
2017:
1965:
1749:
866:
Gastrointestinal: Nausea (5%), diarrhea (2%), gastrointestinal hemorrhage (2%)
5131:
4792:
3949:
3707:
3642:
3472:
3169:
3103:
3073:
2663:
2648:
2643:
2604:
2276:
2051:
1577:
1029:
561:
353:
1410:
Lordkipanidzé M, Marquis-Gravel G, Tanguay JF, Mehta SR, So DY (June 2021).
5075:
5015:
4912:
4897:
4892:
4871:
4819:
4797:
4710:
4680:
4637:
4178:
3712:
3622:
3567:
3557:
3093:
3063:
3041:
3036:
3009:
2958:
2937:
2787:
2726:
2682:
2559:
2502:
2441:
2436:
2417:
2315:
2284:
2196:
2158:
2149:
2132:
2095:
2087:
2052:"Switching from clopidogrel to prasugrel further reduces platelet function"
2036:
1973:
1924:
1807:
1757:
1707:
1646:
1596:
1545:
1447:
1348:
1293:
1222:
1169:
1113:
912:
795:
172:
1339:
1322:
1257:
1160:
1143:
923:(trade name Plavix). These agents reduce the aggregation ("clumping") of
790:
to prevent thrombosis in patients with acute coronary syndrome, including
22:
4887:
4844:
4787:
4782:
4738:
4695:
4660:
4544:
4449:
4051:
3742:
3722:
3702:
3687:
3682:
3632:
3502:
3482:
3412:
3397:
3228:
2963:
2891:
2860:
2792:
2693:
2687:
2677:
2580:
2374:
2364:
997:
973:
920:
916:
847:
80:
1214:
1144:"Prasugrel versus clopidogrel in patients with acute coronary syndromes"
418:
4907:
4866:
4839:
4824:
4814:
4670:
4632:
4539:
4269:
4061:
3976:
3854:
3747:
3732:
3592:
3552:
3537:
3467:
3437:
3364:
3068:
2985:
2968:
2953:
2932:
2917:
2912:
2855:
2840:
2814:
2804:
2799:
2653:
2622:
2554:
2534:
2512:
2401:
2385:
2381:
2330:
1683:
1409:
968:
879:
732:
621:
429:
1275:
4995:
4945:
4861:
4829:
4685:
4612:
4602:
4454:
4444:
4264:
4219:
4016:
3789:
3697:
3692:
3677:
3562:
3512:
3487:
3359:
3309:
3264:
3056:
3051:
3031:
3026:
2973:
2927:
2901:
2896:
2845:
2703:
2626:
2590:
2564:
2529:
2517:
2479:
2474:
2464:
2426:
2396:
2391:
2335:
2310:
1501:
924:
364:
295:
66:
30:
4970:
4965:
4856:
4529:
4086:
3607:
3587:
3492:
3329:
2850:
2835:
2668:
2639:
2630:
2618:
2585:
2431:
1784:
1623:
1495:"Efient (prasugrel) tablets: Highlights of prescribing information"
977:
478:
409:
300:
Urine (~68% inactive metabolites); feces (27% inactive metabolites)
108:
2234:
claims hydrochloride salt of prasugrel; will expire on 3 July 2021
1320:
644:
5079:
5050:
5020:
4990:
4940:
4690:
4675:
4534:
4284:
4163:
4141:
3939:
3477:
3249:
3232:
3121:
3111:
3088:
2886:
2715:
2459:
1141:
1025:
985:
943:
863:
Endocrine and metabolic: Hypercholesterolemia/hyperlipidemia (7%)
5045:
5040:
4752:
3959:
3954:
3919:
3647:
3083:
802:
509:
4726:
4648:
4585:
4509:
4071:
4011:
2345:
2181:. In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.).
2130:
1012:, and patients undergoing PCI show similar pharmacokinetics.
928:
806:
767:
635:
489:
1734:
534:
39:
4168:
3879:
3572:
3542:
2990:
1951:
1558:
1462:"Effient (prasugrel hydrochloride) Prescribing Information"
469:
2131:
Kurokawa T, Fukami T, Yoshida T, Nakajima M (March 2016).
1681:
1902:
850:(3%), noncardiac chest pain (3%), peripheral edema (3%),
2072:
1520:"Current oral antiplatelets: focus update on prasugrel"
759:
and marketed in the United States in cooperation with
5105:
1994:
1199:
875:
Respiratory: Epistaxis (6%), dyspnea (5%), cough (4%)
2221:
claims prasugrel compound; expired on 14 April 2017
1489:
1487:
397:
16:
Medication used to prevent formation of blood clots
3296:4'-O-β-D-Glucosyl-9-O-(6''-deoxysaccharosyl)olivil
1995:Warlo EM, Arnesen H, Seljeflot I (December 2019).
5129:
1524:Journal of the American Board of Family Medicine
1484:
377:
2001:receptor antagonism in coronary artery disease"
344:
3763:
3199:
1076:"European Public Assessment Report for Efient"
667:CC(=O)Oc1cc2c(s1)CCN(C2)C(c3ccccc3F)C(=O)C4CC4
4731:Tooltip Plasma membrane monoamine transporter
4653:Tooltip Equilibrative nucleoside transporters
4590:Tooltip Concentrative nucleoside transporters
3185:
2253:
2189:National Center for Biotechnology Information
938:Clopidogrel, unlike prasugrel, was issued a
112:
805:), and ST elevation myocardial infarction (
3192:
3178:
2260:
2246:
1091:
872:Neuromuscular and skeletal: Back pain (5%)
571:
548:
437:
38:
29:
5138:Adenosine diphosphate receptor inhibitors
2148:
2049:
2026:
2016:
1586:
1576:
1535:
1517:
1437:
1427:
1338:
1283:
1159:
869:Hematologic: Leukopenia (3%), anemia (2%)
457:
5143:Drugs developed by Eli Lilly and Company
4770:
1094:American Journal of Cardiovascular Drugs
967:
544:
417:
290:~7 h (range 2 h to 15 h)
85:
5130:
1954:Journal of Thrombosis and Thrombolysis
902:
786:Prasugrel is used in combination with
562:
241:
216:
3173:
2241:
1468:(FDA). September 2011. Archived from
1137:
1135:
1133:
1131:
743:and an irreversible antagonist of P2Y
517:
497:
229:
103:
71:
2179:"Prasugrel Therapy and CYP Genotype"
2176:
1997:"A brief review on resistance to P2Y
1850:(FDA). 12 March 2010. Archived from
1195:
1193:
996:in the liver to a likewise inactive
828:
327:tetrahydrothienopyridin-2-yl acetate
176:
1905:International Journal of Cardiology
1327:The New England Journal of Medicine
1148:The New England Journal of Medicine
963:
950:
852:thrombotic thrombocytopenic purpura
477:
368:
13:
4152:Tetramethylpyrazine (ligustrazine)
2169:
2116:: CS1 maint: overridden setting (
1937:: CS1 maint: overridden setting (
1828:: CS1 maint: overridden setting (
1770:: CS1 maint: overridden setting (
1720:: CS1 maint: overridden setting (
1667:: CS1 maint: overridden setting (
1609:: CS1 maint: overridden setting (
1369:: CS1 maint: overridden setting (
1306:: CS1 maint: overridden setting (
1243:: CS1 maint: overridden setting (
1182:: CS1 maint: overridden setting (
1128:
1068:
837:
819:
776:percutaneous coronary intervention
14:
5184:
2205:
1800:10.1161/CIRCULATIONAHA.107.740324
1500:. Eli Lilly. 2011. Archived from
1190:
955:Prasugrel produces inhibition of
774:(ACS) who are to be managed with
203:
135:
5115:
2875:Direct thrombin (IIa) inhibitors
2303:Glycoprotein IIb/IIIa inhibitors
1688:The American Journal of Medicine
1203:The Medical Journal of Australia
751:drug class. It was developed by
605:
602:
596:
2498:Thromboxane synthase inhibitors
2137:Drug Metabolism and Disposition
2124:
2076:Drug Metabolism and Disposition
2066:
2043:
1988:
1945:
1896:
1866:
1836:
1778:
1728:
1675:
1617:
1552:
1511:
1454:
1106:10.2165/1131209-000000000-00000
1054:European Medicines Agency (EMA)
1032:salt, which is a white powder.
897:
885:
781:
692:Key:DTGLZDAWLRGWQN-UHFFFAOYSA-N
3768:Tooltip Adenosine triphosphate
1403:
1385:"Product information -Effient"
1377:
1314:
1251:
1085:
1042:
988:and is rapidly metabolized by
614:
608:
590:
1:
5096:Receptor/signaling modulators
3458:8-Phenyl-1,3-dipropylxanthine
1639:10.1016/S0140-6736(09)61525-7
1035:
907:Prasugrel is a member of the
723:, sold under the brand names
2736:Low-molecular-weight heparin
2547:Phosphodiesterase inhibitors
2460:Acetylsalicylic acid/Aspirin
1917:10.1016/j.ijcard.2010.10.040
1880:Food and Drug Administration
1848:Food and Drug Administration
1700:10.1016/j.amjmed.2016.03.042
1537:10.3122/jabfm.2012.03.100270
1466:Food and Drug Administration
1015:
1004:(R-138727). R-138727 has an
935:were similar for each drug.
878:Hypersensitivity, including
747:ADP receptors and is of the
7:
927:by irreversibly binding to
770:thrombosis) in people with
10:
5189:
4598:6-Hydroxy-7-methoxyflavone
3305:-ethylcarboxamidoadenosine
2199:. Bookshelf ID: NBK425796.
2184:Medical Genetics Summaries
1429:10.1016/j.cjco.2020.11.021
580:Chemical and physical data
5089:
4930:
4880:
4768:
4751:
4724:
4646:
4583:
4566:
4177:
3756:
3741:
3258:
3227:
3210:
3130:
3102:
3003:
2946:
2873:
2825:
2714:
2708:(with some II inhibition)
2702:
2612:
2603:
2573:
2545:
2488:
2450:
2412:
2344:
2301:
2292:
2018:10.1186/s12959-019-0197-5
1966:10.1007/s11239-010-0533-x
1750:10.1016/j.ahj.2006.10.010
1518:John J, Koshy SK (2012).
842:Adverse effects include:
700:
675:
655:
633:
620:
584:
579:
560:
528:
508:
488:
468:
448:
428:
408:
388:
363:
335:
309:
304:
294:
281:
271:
261:
253:
193:
188:
163:
149:
123:
93:
79:
61:
51:
46:
37:
28:
5153:2-Fluorophenyl compounds
4775:Tooltip Xanthine oxidase
1578:10.3389/fphys.2018.01550
919:(trade name Ticlid) and
792:unstable angina pectoris
737:formation of blood clots
4365:UDP-N-acetylglucosamine
1565:Frontiers in Physiology
860:Dermatologic: Rash (3%)
772:acute coronary syndrome
277:Active metabolite: ~98%
4809:Cinnamomum osmophloeum
3518:Choline theophyllinate
3018:Plasminogen activators
2490:Thromboxane inhibitors
2414:Prostaglandin analogue
2150:10.1124/dmd.115.068221
2088:10.1124/dmd.105.007989
1846:(Press release). U.S.
1738:American Heart Journal
981:
892:proton pump inhibitors
4052:Opiranserin (VVZ-149)
3393:-Cyclopentyladenosine
3080:serine endopeptidases
2614:Vitamin K antagonists
1340:10.1056/NEJMoa1308075
1161:10.1056/NEJMoa0706482
1006:elimination half-life
992:in the intestine and
971:
799:myocardial infarction
761:Eli Lilly and Company
4851:Pistacia integerrima
4157:Ligusticum wallichii
4135:Ligusticum wallichii
3463:8-Phenyltheophylline
3453:8-Chlorotheophylline
3403:Neladenoson dalanate
2827:Direct Xa inhibitors
2659:Ethyl biscoumacetate
2525:Receptor antagonists
1024:atom. It is used in
957:platelet aggregation
2470:Carbasalate calcium
1507:on 31 January 2012.
1215:10.5694/mja16.00368
903:Mechanism of action
225:(Prescription only)
212:(Prescription only)
25:
3157:Never to phase III
3005:Thrombolytic drugs
2721:glycosaminoglycans
2294:Antiplatelet drugs
2281:antiplatelet drugs
2005:Thrombosis Journal
1744:(1): 66.e9–66.16.
1472:on 18 January 2017
1270:(aug06 2): g6269.
1056:. 25 February 2009
1020:Prasugrel has one
994:carboxylesterase 1
990:carboxylesterase 2
982:
753:Daiichi Sankyo Co.
741:platelet inhibitor
21:
5103:
5102:
4926:
4925:
4903:Mycophenolic acid
4762:
4747:
4746:
4577:
4562:
4561:
4558:
4557:
4129:Angelica sinensis
3221:
3167:
3166:
2999:
2998:
2869:
2868:
2599:
2598:
1794:(25): 2923–2932.
1633:(9694): 989–997.
1276:10.1136/bmj.g6269
1154:(20): 2001–2015.
1002:active metabolite
940:black box warning
915:inhibitors, like
829:Contraindications
718:
717:
646:Interactive image
530:CompTox Dashboard
245:
233:
220:
207:
139:
106:
5180:
5120:
5119:
5118:
5111:
4776:
4772:
4766:
4765:
4756:
4732:
4728:
4654:
4650:
4591:
4587:
4581:
4580:
4571:
3965:Rheum officinale
3769:
3765:
3754:
3753:
3498:Caffeine citrate
3448:7-Methylxanthine
3281:-methyladenosine
3225:
3224:
3215:
3194:
3187:
3180:
3171:
3170:
2979:Drotrecogin alfa
2959:Antithrombin III
2810:Dermatan sulfate
2783:Oligosaccharides
2712:
2711:
2610:
2609:
2346:ADP receptor/P2Y
2299:
2298:
2262:
2255:
2248:
2239:
2238:
2233:
2232:
2228:
2220:
2219:
2215:
2200:
2163:
2162:
2152:
2128:
2122:
2121:
2115:
2107:
2070:
2064:
2063:
2061:
2059:
2047:
2041:
2040:
2030:
2020:
1992:
1986:
1985:
1949:
1943:
1942:
1936:
1928:
1900:
1894:
1893:
1891:
1889:
1870:
1864:
1863:
1861:
1859:
1854:on 15 March 2010
1840:
1834:
1833:
1827:
1819:
1782:
1776:
1775:
1769:
1761:
1732:
1726:
1725:
1719:
1711:
1694:(9): 1002–1005.
1679:
1673:
1672:
1666:
1658:
1621:
1615:
1614:
1608:
1600:
1590:
1580:
1556:
1550:
1549:
1539:
1515:
1509:
1508:
1506:
1499:
1491:
1482:
1481:
1479:
1477:
1458:
1452:
1451:
1441:
1431:
1407:
1401:
1400:
1398:
1396:
1381:
1375:
1374:
1368:
1360:
1342:
1333:(11): 999–1010.
1318:
1312:
1311:
1305:
1297:
1287:
1255:
1249:
1248:
1242:
1234:
1197:
1188:
1187:
1181:
1173:
1163:
1139:
1126:
1125:
1089:
1083:
1082:
1080:
1072:
1066:
1065:
1063:
1061:
1046:
964:Pharmacokinetics
951:Pharmacodynamics
788:low-dose aspirin
755:and produced by
735:used to prevent
714:
713:
706:
648:
628:
616:
610:
607:
604:
598:
592:
575:
564:
553:
552:
538:
536:
521:
501:
481:
461:
441:
421:
401:
381:
371:
370:
348:
286:
243:
240:
231:
228:
218:
215:
205:
202:
180:
137:
134:
116:
105:
102:
89:
75:
42:
33:
26:
24:
20:
5188:
5187:
5183:
5182:
5181:
5179:
5178:
5177:
5163:Thienopyridines
5128:
5127:
5126:
5116:
5114:
5106:
5104:
5099:
5085:
4922:
4876:
4774:
4755:
4743:
4730:
4720:
4716:Propentofylline
4666:Benzodiazepines
4652:
4642:
4589:
4570:
4554:
4173:
4124:Sodium ferulate
4092:Radix puerariae
4067:Phenolphthalein
3767:
3760:
3745:
3737:
3638:Propentofylline
3578:Isovaleric acid
3262:
3254:
3214:
3206:
3201:Purine receptor
3198:
3168:
3163:
3162:
3147:Clinical trials
3126:
3098:
3008:
2995:
2942:
2865:
2821:
2724:
2719:
2707:
2698:
2674:1,3-Indandiones
2616:
2595:
2569:
2541:
2484:
2446:
2408:
2360:Thienopyridines
2349:
2340:
2288:
2269:Antithrombotics
2266:
2230:
2224:
2217:
2211:
2208:
2203:
2177:Dean L (2017).
2172:
2170:Further reading
2167:
2166:
2129:
2125:
2109:
2108:
2071:
2067:
2057:
2055:
2048:
2044:
2000:
1993:
1989:
1950:
1946:
1930:
1929:
1901:
1897:
1887:
1885:
1884:. 12 March 2010
1872:
1871:
1867:
1857:
1855:
1842:
1841:
1837:
1821:
1820:
1783:
1779:
1763:
1762:
1733:
1729:
1713:
1712:
1680:
1676:
1660:
1659:
1622:
1618:
1602:
1601:
1557:
1553:
1516:
1512:
1504:
1497:
1493:
1492:
1485:
1475:
1473:
1460:
1459:
1455:
1408:
1404:
1394:
1392:
1383:
1382:
1378:
1362:
1361:
1319:
1315:
1299:
1298:
1256:
1252:
1236:
1235:
1198:
1191:
1175:
1174:
1140:
1129:
1090:
1086:
1078:
1074:
1073:
1069:
1059:
1057:
1048:
1047:
1043:
1038:
1018:
1010:atherosclerosis
984:Prasugrel is a
966:
953:
932:
905:
900:
888:
840:
838:Adverse effects
831:
822:
820:Approval status
784:
746:
709:
707:
704:(what is this?)
701:
696:
693:
688:
683:
682:
671:
668:
663:
662:
651:
626:
613:
601:
595:
556:
532:
524:
504:
484:
464:
444:
424:
404:
384:
367:
359:
331:
328:
326:
317:
316:
284:
273:Protein binding
263:Bioavailability
255:Pharmacokinetic
249:
184:
152:
145:
126:
119:
57:Effient, Efient
17:
12:
11:
5:
5186:
5176:
5175:
5170:
5168:Acetate esters
5165:
5160:
5155:
5150:
5148:Daiichi Sankyo
5145:
5140:
5125:
5124:
5101:
5100:
5090:
5087:
5086:
5084:
5083:
5069:
5068:
5063:
5058:
5053:
5048:
5043:
5038:
5033:
5028:
5023:
5018:
5013:
5008:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4953:
4948:
4943:
4934:
4932:
4928:
4927:
4924:
4923:
4921:
4920:
4915:
4910:
4905:
4900:
4895:
4890:
4884:
4882:
4878:
4877:
4875:
4874:
4869:
4864:
4859:
4854:
4847:
4842:
4837:
4832:
4827:
4822:
4817:
4812:
4805:
4803:Cinnamaldehyde
4800:
4795:
4790:
4785:
4779:
4777:
4763:
4749:
4748:
4745:
4744:
4742:
4741:
4735:
4733:
4722:
4721:
4719:
4718:
4713:
4708:
4706:Pentoxifylline
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4668:
4663:
4657:
4655:
4644:
4643:
4641:
4640:
4635:
4630:
4625:
4620:
4615:
4610:
4605:
4600:
4594:
4592:
4578:
4564:
4563:
4560:
4559:
4556:
4555:
4553:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4462:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4383:
4382:
4377:
4372:
4367:
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4292:
4287:
4282:
4277:
4272:
4267:
4262:
4257:
4252:
4247:
4242:
4237:
4232:
4227:
4222:
4217:
4212:
4207:
4202:
4197:
4192:
4183:
4181:
4175:
4174:
4172:
4171:
4166:
4161:
4149:
4144:
4139:
4121:
4116:
4111:
4106:
4101:
4096:
4084:
4079:
4074:
4069:
4064:
4059:
4054:
4049:
4044:
4039:
4034:
4029:
4024:
4019:
4014:
4009:
4004:
3999:
3994:
3989:
3984:
3979:
3974:
3969:
3957:
3952:
3947:
3942:
3937:
3932:
3927:
3922:
3917:
3912:
3907:
3902:
3897:
3892:
3883:
3882:
3877:
3872:
3867:
3862:
3857:
3852:
3847:
3842:
3837:
3832:
3827:
3822:
3817:
3812:
3807:
3802:
3797:
3792:
3787:
3782:
3773:
3771:
3751:
3739:
3738:
3736:
3735:
3730:
3725:
3720:
3715:
3710:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3628:Pentoxifylline
3625:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3585:
3583:Istradefylline
3580:
3575:
3570:
3565:
3560:
3555:
3550:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3441:
3440:
3435:
3430:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3387:
3382:
3377:
3372:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3317:
3312:
3307:
3298:
3293:
3288:
3283:
3277:2-(1-Hexynyl)-
3270:
3268:
3256:
3255:
3253:
3252:
3247:
3245:8-Aminoadenine
3238:
3236:
3222:
3208:
3207:
3197:
3196:
3189:
3182:
3174:
3165:
3164:
3161:
3160:
3159:
3158:
3155:
3144:
3138:
3132:
3131:
3128:
3127:
3125:
3124:
3119:
3114:
3108:
3106:
3100:
3099:
3097:
3096:
3091:
3086:
3076:
3071:
3066:
3061:
3060:
3059:
3054:
3046:
3045:
3044:
3039:
3034:
3029:
3014:
3012:
3001:
3000:
2997:
2996:
2994:
2993:
2988:
2983:
2982:
2981:
2971:
2966:
2961:
2956:
2950:
2948:
2944:
2943:
2941:
2940:
2935:
2930:
2925:
2920:
2915:
2906:
2905:
2904:
2899:
2894:
2879:
2877:
2871:
2870:
2867:
2866:
2864:
2863:
2858:
2853:
2848:
2843:
2838:
2832:
2830:
2823:
2822:
2820:
2819:
2818:
2817:
2812:
2807:
2797:
2796:
2795:
2790:
2780:
2779:
2778:
2773:
2768:
2763:
2758:
2753:
2748:
2743:
2732:
2730:
2709:
2700:
2699:
2697:
2696:
2690:
2685:
2680:
2671:
2666:
2661:
2656:
2651:
2646:
2636:
2634:
2607:
2605:Anticoagulants
2601:
2600:
2597:
2596:
2594:
2593:
2588:
2583:
2577:
2575:
2571:
2570:
2568:
2567:
2562:
2557:
2551:
2549:
2543:
2542:
2540:
2539:
2538:
2537:
2532:
2522:
2521:
2520:
2515:
2510:
2494:
2492:
2486:
2485:
2483:
2482:
2477:
2472:
2467:
2462:
2456:
2454:
2452:COX inhibitors
2448:
2447:
2445:
2444:
2439:
2434:
2429:
2423:
2421:
2410:
2409:
2407:
2406:
2405:
2404:
2399:
2394:
2379:
2378:
2377:
2372:
2367:
2356:
2354:
2347:
2342:
2341:
2339:
2338:
2333:
2328:
2323:
2318:
2313:
2307:
2305:
2296:
2290:
2289:
2277:anticoagulants
2265:
2264:
2257:
2250:
2242:
2236:
2235:
2222:
2207:
2206:External links
2204:
2202:
2201:
2173:
2171:
2168:
2165:
2164:
2143:(3): 409–416.
2123:
2082:(4): 600–607.
2065:
2054:. TheHeart.org
2042:
1998:
1987:
1960:(2): 233–234.
1944:
1911:(3): 424–429.
1895:
1865:
1835:
1777:
1727:
1674:
1616:
1551:
1530:(3): 343–349.
1510:
1483:
1453:
1422:(6): 814–821.
1402:
1376:
1313:
1250:
1209:(3): 128–133.
1189:
1127:
1100:(4): 213–229.
1084:
1067:
1040:
1039:
1037:
1034:
1017:
1014:
980:of each other.
965:
962:
952:
949:
930:
909:thienopyridine
904:
901:
899:
896:
887:
884:
883:
882:
876:
873:
870:
867:
864:
861:
858:
855:
839:
836:
830:
827:
821:
818:
783:
780:
749:thienopyridine
744:
716:
715:
698:
697:
695:
694:
691:
689:
686:
678:
677:
676:
673:
672:
670:
669:
666:
658:
657:
656:
653:
652:
650:
649:
641:
639:
631:
630:
624:
618:
617:
611:
599:
593:
588:
582:
581:
577:
576:
566:
558:
557:
555:
554:
546:DTXSID70861544
541:
539:
526:
525:
523:
522:
514:
512:
506:
505:
503:
502:
494:
492:
486:
485:
483:
482:
474:
472:
466:
465:
463:
462:
454:
452:
446:
445:
443:
442:
434:
432:
426:
425:
423:
422:
414:
412:
406:
405:
403:
402:
394:
392:
386:
385:
383:
382:
374:
372:
361:
360:
358:
357:
341:
339:
333:
332:
330:
329:
320:
312:
311:
310:
307:
306:
302:
301:
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288:
279:
278:
275:
269:
268:
265:
259:
258:
251:
250:
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247:
238:
226:
213:
199:
197:
191:
190:
186:
185:
183:
182:
169:
167:
161:
160:
155:
153:administration
147:
146:
144:
143:
141:
131:
129:
121:
120:
118:
117:
99:
97:
91:
90:
83:
77:
76:
69:
59:
58:
55:
49:
48:
44:
43:
35:
34:
15:
9:
6:
4:
3:
2:
5185:
5174:
5173:Cyclopropanes
5171:
5169:
5166:
5164:
5161:
5159:
5156:
5154:
5151:
5149:
5146:
5144:
5141:
5139:
5136:
5135:
5133:
5123:
5113:
5112:
5109:
5098:
5097:
5094:
5088:
5081:
5077:
5074:
5071:
5070:
5067:
5064:
5062:
5059:
5057:
5054:
5052:
5049:
5047:
5044:
5042:
5039:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4952:
4949:
4947:
4944:
4942:
4939:
4936:
4935:
4933:
4929:
4919:
4916:
4914:
4911:
4909:
4906:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4885:
4883:
4879:
4873:
4870:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4852:
4848:
4846:
4843:
4841:
4838:
4836:
4833:
4831:
4828:
4826:
4823:
4821:
4818:
4816:
4813:
4811:
4810:
4806:
4804:
4801:
4799:
4796:
4794:
4793:Benzbromarone
4791:
4789:
4786:
4784:
4781:
4780:
4778:
4773:
4767:
4764:
4760:
4754:
4750:
4740:
4737:
4736:
4734:
4729:
4723:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4658:
4656:
4651:
4645:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4619:
4616:
4614:
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4595:
4593:
4588:
4582:
4579:
4575:
4569:
4565:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4425:AR-C 118925XX
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4385:
4384:
4381:
4378:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4355:UDP-galactose
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4301:
4298:
4296:
4293:
4291:
4288:
4286:
4283:
4281:
4278:
4276:
4273:
4271:
4268:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4196:
4193:
4191:
4188:
4185:
4184:
4182:
4180:
4176:
4170:
4167:
4165:
4162:
4159:
4158:
4153:
4150:
4148:
4145:
4143:
4140:
4137:
4136:
4131:
4130:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4094:
4093:
4088:
4085:
4083:
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4053:
4050:
4048:
4045:
4043:
4040:
4038:
4035:
4033:
4030:
4028:
4025:
4023:
4020:
4018:
4015:
4013:
4010:
4008:
4005:
4003:
4000:
3998:
3995:
3993:
3990:
3988:
3985:
3983:
3980:
3978:
3975:
3973:
3970:
3967:
3966:
3961:
3958:
3956:
3953:
3951:
3950:Chelerythrine
3948:
3946:
3945:Calmidazolium
3943:
3941:
3938:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3885:
3884:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3858:
3856:
3853:
3851:
3848:
3846:
3843:
3841:
3838:
3836:
3833:
3831:
3830:Cibacron blue
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3781:
3778:
3775:
3774:
3772:
3766:
3759:
3755:
3752:
3749:
3744:
3740:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3708:Theodrenaline
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3643:Proxyphylline
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3473:Aminophylline
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3443:
3442:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3392:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3308:
3306:
3304:
3299:
3297:
3294:
3292:
3289:
3287:
3284:
3282:
3280:
3275:
3272:
3271:
3269:
3266:
3261:
3257:
3251:
3248:
3246:
3243:
3240:
3239:
3237:
3234:
3230:
3226:
3223:
3219:
3213:
3209:
3205:
3202:
3195:
3190:
3188:
3183:
3181:
3176:
3175:
3172:
3156:
3154:
3151:
3150:
3148:
3145:
3142:
3139:
3137:
3134:
3133:
3129:
3123:
3120:
3118:
3115:
3113:
3110:
3109:
3107:
3105:
3104:Non-medicinal
3101:
3095:
3092:
3090:
3087:
3085:
3081:
3077:
3075:
3074:Streptokinase
3072:
3070:
3067:
3065:
3062:
3058:
3055:
3053:
3050:
3049:
3047:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3024:
3023:
3019:
3016:
3015:
3013:
3011:
3010:fibrinolytics
3006:
3002:
2992:
2989:
2987:
2984:
2980:
2977:
2976:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2951:
2949:
2945:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2910:
2907:
2903:
2900:
2898:
2895:
2893:
2890:
2889:
2888:
2884:
2881:
2880:
2878:
2876:
2872:
2862:
2859:
2857:
2854:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2833:
2831:
2828:
2824:
2816:
2813:
2811:
2808:
2806:
2803:
2802:
2801:
2798:
2794:
2791:
2789:
2786:
2785:
2784:
2781:
2777:
2774:
2772:
2769:
2767:
2764:
2762:
2759:
2757:
2754:
2752:
2749:
2747:
2744:
2742:
2739:
2738:
2737:
2734:
2733:
2731:
2728:
2722:
2717:
2713:
2710:
2705:
2701:
2695:
2691:
2689:
2686:
2684:
2681:
2679:
2675:
2672:
2670:
2667:
2665:
2664:Phenprocoumon
2662:
2660:
2657:
2655:
2652:
2650:
2649:Coumatetralyl
2647:
2645:
2644:Acenocoumarol
2641:
2638:
2637:
2635:
2632:
2628:
2624:
2620:
2615:
2611:
2608:
2606:
2602:
2592:
2589:
2587:
2584:
2582:
2579:
2578:
2576:
2572:
2566:
2563:
2561:
2558:
2556:
2553:
2552:
2550:
2548:
2544:
2536:
2533:
2531:
2528:
2527:
2526:
2523:
2519:
2516:
2514:
2511:
2508:
2504:
2501:
2500:
2499:
2496:
2495:
2493:
2491:
2487:
2481:
2478:
2476:
2473:
2471:
2468:
2466:
2463:
2461:
2458:
2457:
2455:
2453:
2449:
2443:
2440:
2438:
2435:
2433:
2430:
2428:
2425:
2424:
2422:
2419:
2415:
2411:
2403:
2400:
2398:
2395:
2393:
2390:
2389:
2387:
2383:
2380:
2376:
2373:
2371:
2368:
2366:
2363:
2362:
2361:
2358:
2357:
2355:
2353:
2350:
2343:
2337:
2334:
2332:
2329:
2327:
2324:
2322:
2319:
2317:
2314:
2312:
2309:
2308:
2306:
2304:
2300:
2297:
2295:
2291:
2286:
2282:
2278:
2274:
2273:thrombolytics
2270:
2263:
2258:
2256:
2251:
2249:
2244:
2243:
2240:
2227:
2223:
2214:
2210:
2209:
2198:
2194:
2190:
2186:
2185:
2180:
2175:
2174:
2160:
2156:
2151:
2146:
2142:
2138:
2134:
2127:
2119:
2113:
2105:
2101:
2097:
2093:
2089:
2085:
2081:
2077:
2069:
2053:
2050:O'Riordan M.
2046:
2038:
2034:
2029:
2024:
2019:
2014:
2010:
2006:
2002:
1991:
1983:
1979:
1975:
1971:
1967:
1963:
1959:
1955:
1948:
1940:
1934:
1926:
1922:
1918:
1914:
1910:
1906:
1899:
1883:
1881:
1875:
1869:
1853:
1849:
1845:
1839:
1831:
1825:
1817:
1813:
1809:
1805:
1801:
1797:
1793:
1789:
1781:
1773:
1767:
1759:
1755:
1751:
1747:
1743:
1739:
1731:
1723:
1717:
1709:
1705:
1701:
1697:
1693:
1689:
1685:
1678:
1670:
1664:
1656:
1652:
1648:
1644:
1640:
1636:
1632:
1628:
1620:
1612:
1606:
1598:
1594:
1589:
1584:
1579:
1574:
1570:
1566:
1562:
1555:
1547:
1543:
1538:
1533:
1529:
1525:
1521:
1514:
1503:
1496:
1490:
1488:
1471:
1467:
1463:
1457:
1449:
1445:
1440:
1435:
1430:
1425:
1421:
1417:
1413:
1406:
1390:
1389:Health Canada
1386:
1380:
1372:
1366:
1358:
1354:
1350:
1346:
1341:
1336:
1332:
1328:
1324:
1317:
1309:
1303:
1295:
1291:
1286:
1281:
1277:
1273:
1269:
1265:
1261:
1254:
1246:
1240:
1232:
1228:
1224:
1220:
1216:
1212:
1208:
1204:
1196:
1194:
1185:
1179:
1171:
1167:
1162:
1157:
1153:
1149:
1145:
1138:
1136:
1134:
1132:
1123:
1119:
1115:
1111:
1107:
1103:
1099:
1095:
1088:
1077:
1071:
1055:
1051:
1050:"Efient EPAR"
1045:
1041:
1033:
1031:
1030:hydrochloride
1027:
1023:
1013:
1011:
1007:
1003:
999:
995:
991:
987:
979:
975:
970:
961:
958:
948:
945:
941:
936:
933:
926:
922:
918:
914:
910:
895:
893:
881:
877:
874:
871:
868:
865:
862:
859:
856:
853:
849:
845:
844:
843:
835:
826:
817:
813:
810:
808:
804:
800:
797:
793:
789:
779:
777:
773:
769:
764:
762:
758:
754:
750:
742:
738:
734:
730:
726:
722:
712:
705:
699:
690:
685:
684:
681:
674:
665:
664:
661:
654:
647:
643:
642:
640:
637:
632:
625:
623:
619:
589:
587:
583:
578:
574:
570:
567:
565:
563:ECHA InfoCard
559:
551:
547:
543:
542:
540:
531:
527:
520:
519:ChEMBL1201772
516:
515:
513:
511:
507:
500:
496:
495:
493:
491:
487:
480:
476:
475:
473:
471:
467:
460:
456:
455:
453:
451:
447:
440:
436:
435:
433:
431:
427:
420:
416:
415:
413:
411:
407:
400:
396:
395:
393:
391:
387:
380:
376:
375:
373:
366:
362:
355:
354:hydrochloride
351:
347:
343:
342:
340:
338:
334:
325:)-5--4,5,6,7-
324:
319:
318:
315:
308:
303:
299:
297:
293:
289:
287:
280:
276:
274:
270:
266:
264:
260:
256:
252:
246: Rx-only
239:
237:
227:
224:
214:
211:
201:
200:
198:
196:
192:
187:
179:
174:
171:
170:
168:
166:
162:
159:
156:
154:
148:
142:
133:
132:
130:
128:
122:
115:
110:
101:
100:
98:
96:
92:
88:
84:
82:
78:
74:
70:
68:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
5092:
5091:
5076:Chrysophanol
5072:
5016:Hypoxanthine
4937:
4917:
4913:Pralatrexate
4898:Methotrexate
4893:Azathioprine
4872:Topiroxostat
4849:
4820:Myo-inositol
4807:
4798:Caffeic acid
4711:Progesterone
4681:Dipyridamole
4661:Barbiturates
4638:Progesterone
4514:
4420:AR-C 69931MX
4415:AR-C 67085MX
4387:Antagonists:
4386:
4240:AR-C 67085MX
4186:
4155:
4133:
4127:
4090:
4057:Oxidized-ATP
4002:JNJ-47965567
3963:
3887:Antagonists:
3886:
3860:L-β,γ-Me-ATP
3840:D-β,γ-Me-ATP
3776:
3713:Theophylline
3623:Paraxanthine
3568:Fenethylline
3558:Enprofylline
3523:Ciforadenant
3445:Antagonists:
3444:
3408:Piclidenoson
3390:
3302:
3286:2-Cl-IB-MECA
3278:
3273:
3241:
3094:Fibrinolysin
3064:Anistreplase
3042:Desmoteplase
3037:Tenecteplase
2938:Ximelagatran
2788:Fondaparinux
2727:antithrombin
2683:Diphenadione
2560:Dipyridamole
2503:Dipyridamole
2442:Treprostinil
2437:Prostacyclin
2369:
2316:Eptifibatide
2183:
2140:
2136:
2126:
2112:cite journal
2079:
2075:
2068:
2056:. Retrieved
2045:
2008:
2004:
1990:
1957:
1953:
1947:
1933:cite journal
1908:
1904:
1898:
1886:. Retrieved
1877:
1868:
1856:. Retrieved
1852:the original
1838:
1824:cite journal
1791:
1787:
1780:
1766:cite journal
1741:
1737:
1730:
1716:cite journal
1691:
1687:
1677:
1663:cite journal
1630:
1626:
1619:
1605:cite journal
1568:
1564:
1554:
1527:
1523:
1513:
1502:the original
1474:. Retrieved
1470:the original
1456:
1419:
1415:
1405:
1393:. Retrieved
1388:
1379:
1365:cite journal
1330:
1326:
1316:
1302:cite journal
1267:
1263:
1253:
1239:cite journal
1206:
1202:
1178:cite journal
1151:
1147:
1097:
1093:
1087:
1081:. EMA. 2009.
1070:
1058:. Retrieved
1053:
1044:
1028:form as the
1019:
983:
954:
937:
913:ADP receptor
906:
898:Pharmacology
889:
886:Interactions
841:
832:
823:
814:
811:
796:ST elevation
785:
782:Medical uses
765:
728:
724:
720:
719:
708:
702:
322:
283:Elimination
195:Legal status
189:Legal status
95:License data
18:
4938:Precursors:
4918:Many others
4888:Aminopterin
4845:Phytic acid
4788:Amflutizole
4783:Allopurinol
4739:Decynium-22
4696:Hexobendine
4568:Transporter
4545:Ticlopidine
4450:Clopidogrel
4360:UDP-glucose
4099:Purotoxin 1
3930:AZ-11645373
3925:AZ-10606120
3723:Tracazolate
3703:Theobromine
3688:SCH-442,416
3683:Rolofylline
3633:Preladenant
3503:Cartazolate
3483:Bamifylline
3433:Tecadenoson
3428:Sonedenoson
3423:Selodenoson
3418:SDZ WAG 994
3413:Regadenoson
3398:Namodenoson
3350:Capadenoson
3345:Binodenoson
3340:BAY 60–6583
3143:from market
2964:Defibrotide
2892:Bivalirudin
2861:Rivaroxaban
2800:Heparinoids
2793:Idraparinux
2694:Tioclomarol
2688:Phenindione
2678:Clorindione
2581:Cloricromen
2375:Ticlopidine
2365:Clopidogrel
1788:Circulation
1476:16 December
1395:18 February
1060:5 September
998:thiolactone
976:; they are
974:thiolactone
921:clopidogrel
917:ticlopidine
848:bradycardia
629: g·mol
569:100.228.719
499:CHEBI:87715
350:389574-19-0
346:150322-43-3
305:Identifiers
81:MedlinePlus
53:Trade names
5132:Categories
4908:Pemetrexed
4867:Tisopurine
4840:Oxipurinol
4835:Niraxostat
4825:Kaempferol
4815:Febuxostat
4759:inhibitors
4671:Cilostazol
4633:Phloridzin
4540:Ticagrelor
4410:AR-C 66096
4270:Diquafosol
4215:α,β-Me-ATP
4200:2-Thio-UTP
4109:Ro 0437626
4062:Phenol Red
3977:Gefapixant
3972:Evans blue
3855:Ivermectin
3785:α,β-Me-ATP
3748:nucleotide
3733:ZM-241,385
3718:Tozadenant
3593:MRE3008F20
3553:Dyphylline
3538:Dimethazan
3468:Acefylline
3438:UK-432,097
3370:Evodenoson
3365:CP-532,903
3325:Apadenoson
3204:modulators
3069:Monteplase
2986:Ramatroban
2969:Nafamostat
2954:Abelacimab
2933:Melagatran
2918:Dabigatran
2913:Argatroban
2856:Otamixaban
2841:Betrixaban
2829:("xabans")
2815:Sulodexide
2805:Danaparoid
2776:Tinzaparin
2766:Parnaparin
2761:Nadroparin
2756:Enoxaparin
2751:Dalteparin
2746:Certoparin
2706:inhibitors
2654:Dicoumarol
2555:Cilostazol
2535:Terutroban
2513:Picotamide
2402:Ticagrelor
2386:nucleoside
2382:Nucleotide
2352:inhibitors
2331:Sibrafiban
2226:US 6693115
2213:US 5288726
1036:References
880:angioedema
739:. It is a
733:medication
634:3D model (
622:Molar mass
459:34K66TBT99
430:ChemSpider
390:IUPHAR/BPS
337:CAS Number
314:IUPAC name
5093:See also:
4996:Guanosine
4946:Adenosine
4862:Quercetin
4830:Myricetin
4686:Estradiol
4613:Estradiol
4603:Adenosine
4515:Prasugrel
4455:Elinogrel
4445:Cangrelor
4390:2-Me-SAMP
4330:PAPET-ATP
4290:INS-37217
4265:Denufosol
4220:Adenosine
4210:5-OMe-UDP
4195:2-Me-SATP
4190:2-Me-SADP
4187:Agonists:
4082:PSB-12062
4017:Magnesium
3982:GW-791343
3870:PAPET-ATP
3790:Adenosine
3780:2-Me-SATP
3777:Agonists:
3698:Theacrine
3693:SCH-58261
3678:Reversine
3563:Etazolate
3513:CGS-15943
3488:Cafedrine
3360:CGS-21680
3310:Adenosine
3291:2'-MeCCPA
3274:Agonists:
3265:adenosine
3242:Agonists:
3153:Phase III
3141:Withdrawn
3057:Urokinase
3052:Saruplase
3032:Reteplase
3027:Alteplase
2974:Protein C
2928:Inogatran
2923:Efegatran
2909:Univalent
2902:Lepirudin
2897:Desirudin
2846:Darexaban
2771:Reviparin
2741:Bemiparin
2704:Factor Xa
2640:Coumarins
2617:(inhibit
2591:Vorapaxar
2565:Triflusal
2530:Terbogrel
2518:Terbogrel
2507:+ aspirin
2480:Triflusal
2475:Indobufen
2465:Aloxiprin
2427:Beraprost
2397:Elinogrel
2392:Cangrelor
2370:Prasugrel
2336:Tirofiban
2326:Roxifiban
2321:Orbofiban
2311:Abciximab
2011:(1): 11.
1655:205956050
1357:205095981
1016:Chemistry
978:tautomers
925:platelets
911:class of
721:Prasugrel
296:Excretion
285:half-life
151:Routes of
125:Pregnancy
114:Prasugrel
73:Monograph
67:Drugs.com
23:Prasugrel
5122:Medicine
4971:Cytidine
4966:Cytosine
4857:Propolis
4623:KGO-2173
4618:KGO-2142
4608:dMeThPmR
4574:blockers
4530:Regrelor
4520:PSB-0739
4490:MRS-2578
4485:MRS-2500
4480:MRS-2395
4475:MRS-2279
4470:MRS-2211
4465:MRS-2179
4340:PSB-1114
4335:PSB-0474
4320:MRS-4062
4315:MRS-2957
4310:MRS-2768
4305:MRS-2693
4300:MRS-2690
4295:MRS-2365
4205:5-Br-UDP
4147:TC-P 262
4087:Puerarin
4022:MRS-2159
3997:isoPPADS
3915:A-839977
3910:A-804598
3905:A-740003
3900:A-438079
3895:A-317491
3865:MRS-2219
3728:VUF-5574
3673:PSB-1115
3618:MRS-3777
3613:MRS-1754
3608:MRS-1706
3603:MRS-1334
3598:MRS-1220
3588:KF-26777
3533:CVT-6883
3508:CGH-2466
3493:Caffeine
3385:LUF-5845
3380:LUF-5835
3375:GR 79236
3330:ATL-146e
3212:Receptor
2883:Bivalent
2851:Edoxaban
2836:Apixaban
2669:Warfarin
2586:Ditazole
2432:Iloprost
2388:analogs
2197:28520385
2191:(NCBI).
2159:26718653
2096:16415119
2037:31198410
1982:20617890
1974:21088983
1925:21093072
1888:13 March
1858:13 March
1808:18056526
1758:17174640
1708:27143321
1647:19726078
1597:30510515
1571:: 1550.
1546:22570398
1448:34169260
1416:CJC Open
1349:23991622
1294:25954988
1231:13014429
1223:27465769
1170:17982182
1122:37160513
1114:19655817
711:(verify)
410:DrugBank
165:ATC code
158:By mouth
140: B1
127:category
109:DailyMed
5158:Ketones
5080:rhubarb
5073:Others:
5051:Uridine
5021:Inosine
4991:Guanine
4941:Adenine
4691:Ethanol
4676:Dilazep
4628:MeThPmR
4535:Suramin
4440:C1330-7
4285:INS-365
4164:TNP-ATP
4142:Suramin
3940:Calcium
3668:PSB-788
3663:PSB-603
3478:ATL-444
3250:Adenine
3233:adenine
3218:ligands
3122:Oxalate
3112:Citrate
3089:Brinase
2887:Hirudin
2716:Heparin
2692:Other:
2104:1698598
2058:1 April
2028:6558673
1816:8226182
1588:6252380
1464:. U.S.
1439:8209390
1285:4208629
1026:racemic
986:prodrug
944:CYP2C19
778:(PCI).
731:, is a
725:Effient
586:Formula
439:5293653
419:DB06209
379:6918456
365:PubChem
181:)
175: (
173:B01AC22
111::
87:a609027
5108:Portal
5046:Uracil
5041:Ribose
4931:Others
4881:Others
4753:Enzyme
4500:NF-340
4495:NF-157
4395:A3P5PS
4325:NF-546
4047:NF-449
4042:NF-279
4037:NF-157
4032:NF-110
4027:NF-023
3960:Emodin
3955:Copper
3920:AF-353
3890:5-BDBD
3850:HT-AMP
3658:PSB-36
3653:PSB-11
3648:PSB-10
3136:WHO-EM
3084:Ancrod
3078:Other
2725:(bind
2718:group/
2231:
2218:
2195:
2157:
2102:
2094:
2035:
2025:
1980:
1972:
1923:
1814:
1806:
1756:
1706:
1653:
1645:
1627:Lancet
1595:
1585:
1544:
1446:
1436:
1391:. 2021
1355:
1347:
1292:
1282:
1229:
1221:
1168:
1120:
1112:
1022:chiral
803:NSTEMI
794:, non-
729:Efient
660:SMILES
627:373.44
510:ChEMBL
479:D05597
236:℞-only
234:
221:
208:
107:
4701:NBMPR
4510:PPADS
4435:BzATP
4400:AMPαS
4380:UTPγS
4350:UDPβS
4250:ATPγS
4230:ADPβS
4114:Ro 51
4077:PPNDS
4072:PPADS
4012:KN-62
4007:KN-04
3825:BzATP
3820:ATPγS
3548:DPCPX
3022:r-tPA
2947:Other
2574:Other
2100:S2CID
1978:S2CID
1882:(FDA)
1878:U.S.
1812:S2CID
1651:S2CID
1505:(PDF)
1498:(PDF)
1353:S2CID
1227:S2CID
1118:S2CID
1079:(PDF)
854:(TTP)
807:STEMI
768:stent
680:InChI
636:JSmol
490:ChEBI
4727:PMAT
4649:ENTs
4586:CNTs
4525:RB-2
4460:Ip5I
4405:Ap4A
4370:Up3U
4260:dATP
4235:Ap3A
4169:Zinc
4119:RO-3
4104:RB-2
3992:Ip5I
3880:Zinc
3810:Ap5A
3805:Ap4A
3573:IBMX
3543:DMPX
3355:CCPA
3117:EDTA
3048:UPA
2991:REG1
2418:PGI2
2279:and
2193:PMID
2155:PMID
2118:link
2092:PMID
2060:2011
2033:PMID
1970:PMID
1939:link
1921:PMID
1890:2010
1860:2010
1830:link
1804:PMID
1772:link
1754:PMID
1722:link
1704:PMID
1669:link
1643:PMID
1611:link
1593:PMID
1542:PMID
1478:2019
1444:PMID
1397:2021
1371:link
1345:PMID
1308:link
1290:PMID
1245:link
1219:PMID
1184:link
1166:PMID
1110:PMID
1062:2024
727:and
470:KEGG
450:UNII
399:7562
267:≥79%
257:data
63:AHFS
5066:UTP
5061:UDP
5056:UMP
5036:ITP
5031:IDP
5026:IMP
5011:GTP
5006:GDP
5001:GMP
4986:CTP
4981:CDP
4976:CMP
4961:ATP
4956:ADP
4951:AMP
4550:UDP
4505:PIT
4430:ATP
4375:UTP
4345:UDP
4280:ITP
4275:IDP
4255:CTP
4245:ATP
4225:ADP
4179:P2Y
3987:HMA
3935:BBG
3875:UTP
3845:GTP
3835:CTP
3815:ATP
3800:AMP
3795:ADP
3764:ATP
3758:P2X
3528:CPX
3335:ATP
3320:AMP
3315:ADP
3301:5'-
2623:VII
2285:B01
2283:) (
2145:doi
2084:doi
2023:PMC
2013:doi
1962:doi
1913:doi
1909:155
1796:doi
1792:116
1746:doi
1742:153
1696:doi
1692:129
1635:doi
1631:374
1583:PMC
1573:doi
1532:doi
1434:PMC
1424:doi
1335:doi
1331:369
1280:PMC
1272:doi
1268:349
1264:BMJ
1211:doi
1207:205
1156:doi
1152:357
1102:doi
929:P2Y
757:Ube
535:EPA
369:CID
223:POM
178:WHO
5134::
4771:XO
4132:,
3743:P2
3260:P1
3229:P0
3149::
3082::
3020::
2911::
2885::
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2629:,
2627:IX
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2621:,
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217:UK
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