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Postpartum infections

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943:(Allgemeines Krankenhaus), where medical students received their training. Working without knowledge of Holmes' essay, Semmelweis noticed his ward's 16% mortality rate from fever was substantially higher than the 2% mortality rate in the Second Division, where midwifery students were trained. Semmelweis also noticed that puerperal fever was rare in women who gave birth before arriving at the hospital. Semmelweis noted that doctors in First Division performed autopsies each morning on women who had died the previous day, but the midwives were not required or allowed to perform such autopsies. He made the connection between autopsies and puerperal fever after a colleague, 2224:: "Whenever puerperal fever is rife, or when a practitioner has attended any one example of it, he should use most diligent ablution; he should even wash his hands with some disinfecting fluid, a weak solution of chlorine for instance: he should avoid going in the same dress to any other of his midwifery patients: in short, he should take all those precautions which, when the danger is understood, common sense will suggest, against his clothes or his body becoming a vehicle of contagion and death between one patient and another." 804: 42: 3404: 927:, a well-known obstetrician, who stated, "Doctors are gentlemen, and gentlemen's hands are clean." Richard Gordon states that Holmes' exhortations "outraged obstetricians, particularly in Philadelphia". In those days, "surgeons operated in blood-stiffened frock coats—the stiffer the coat, the prouder the busy surgeon", "pus was as inseparable from surgery as blood", and "Cleanliness was next to prudishness". He quotes 281:. This increases to 5% to 13% among those who have more difficult deliveries and 50% with C-sections before the use of preventive antibiotics. In 2015, these infections resulted in 17,900 deaths down from 34,000 deaths in 1990. They are the cause of about 10% of deaths around the time of pregnancy. The first known descriptions of the condition date back to at least the 5th century BCE in the writings of 1021:, contracted childbed fever after giving birth to him and died nine days later. Her infant son was also in perilous health following the birth; the adult Rousseau later wrote that "I came into the world with so few signs of life that little hope was entertained of preserving me". He was nursed back to health by an aunt. French natural philosopher 2171:
nature, and that the infection was as readily communicated as that of smallpox, or measles, and operated more speedily than any other infection, with which I am acquainted." From p. 64: "It is a disagreeable declaration for me to mention, that I myself was the means of carrying the infection to a great number of women."
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solution, before a delivery reduced childbed fever fatalities by 90%. Publication of his findings was not well received by the medical profession. The idea conflicted both with the existing medical concepts and with the image doctors had of themselves. The scorn and ridicule of doctors was so extreme
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Semmelweis began experimenting with various cleansing agents and, from May 1847, ordered all doctors and students working in the First Division wash their hands in chlorinated lime solution before starting ward work, and later before each vaginal examination. The mortality rate from puerperal fever
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On p. 63, Gordon recognized the puerperal fever as infectious: "But this disease seized such women only, as were visited, or delivered, by a practitioner, or taken care of by a nurse, who had previously attended patients affected with the disease. In short, I had evident proofs of its infectious
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and controversially concluded that puerperal fever was frequently carried from patient to patient by physicians and nurses; he suggested that clean clothing and avoidance of autopsies by those aiding birth would prevent the spread of puerperal fever. Holmes quoted Dr. James Blundell as stating,
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Antibiotics have been used to prevent and treat these infections—however, the misuse of antibiotics is a serious problem for global health. It is recommended that guidelines be followed that outline when it is appropriate to give antibiotics and which antibiotics are most effective.
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Puerperal infections in the 18th and 19th centuries affected, on average, 6 to 9 women in every 1,000 births, killing two to three of them with peritonitis or sepsis. It was the single most common cause of maternal mortality, accounting for about half of all deaths related to
842:, and women were subjected to crowding, frequent vaginal examinations, and the use of contaminated instruments, dressings, and bedding. It was common for a doctor to deliver one baby after another, without washing his hands or changing clothes between patients. 920:"... in my own family, I had rather that those I esteemed the most should be delivered unaided, in a stable, by the mangerside, than that they should receive the best help, in the fairest apartment, but exposed to the vapors of this pitiless disease." 795:, which over the same period had declined but has seen a rise in last decade worldwide especially in Asia with smaller outbreaks in US and Canada. UK had reported 12,906 cases between September 2015 and April 2016 which is the largest outbreak since 1969. 881:(1752–1799) warned that the disease was transmitted from one case to another by midwives and doctors. Gordon wrote, "It is a disagreeable declaration for me to mention, that I myself was the means of carrying the infection to a great number of women." 849:
in 1646. Hospitals throughout Europe and America consistently reported death rates between 20% and 25% of all women giving birth, punctuated by intermittent epidemics with up to 100% fatalities of women giving birth in childbirth wards.
330:(blood poisoning) or other illnesses, especially when her resistance has been lowered by long labour or severe bleeding. Puerperal infection is most common on the raw surface of the interior of the uterus after separation of the 931:
on that era: "There was no object in being clean. Indeed, cleanliness was out of place. It was considered to be finicking and affected. An executioner might as well manicure his nails before chopping off a head".
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The number of cases of puerperal sepsis per year shows wide variations among published literature—this may be related to different definitions, recordings etc. Globally, bacterial infections are the cause of 10% of
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greater than 38.0 °C (100.4 °F), chills, low abdominal pain, and possibly bad-smelling vaginal discharge. It usually occurs after the first 24 hours and within the first ten days following delivery.
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In the United States, puerperal infections are believed to occur in between 1% and 8% of all births. About three die from puerperal sepsis for every 100,000 births. The single most important risk factor is
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around the time of surgery. Treatment of established infections is with antibiotics, with most people improving in two to three days. In those with mild disease, oral antibiotics may be used; otherwise
1286:"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015" 285:. These infections were a very common cause of death around the time of childbirth starting in at least the 18th century until the 1930s when antibiotics were introduced. In 1847, Hungarian physician 522:
A temperature rise above 38 °C (100.4 °F) maintained over 24 hours or recurring during the period from the end of the first to the end of the 10th day after childbirth or abortion. (ICD-10)
820: 1234:"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015" 2323:
From p. 104: Speaking of a physician in Philadelphia, Pennsylvania, Meigs said: "He is a gentlemen who is scrupulously careful of his personal appearance, … But a gentleman's hands are clean."
1394:"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013" 484:
PPD 2–3: endometritis ( the most common cause ) risk factors include emergency cesarean section, prolonged membrane rupture, prolonged labor, and multiple vaginal examinations during labor.
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in the division fell from 18% in May 1847 to less than 3% in June–November of the same year. While his results were extraordinary, he was treated with skepticism and ridicule (see
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Saving Mothers' Lives: Reviewing maternal deaths to make motherhood safer – 2003–2005. The Seventh Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom
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PPD 5–6: septic pelvic thrombophlebitis risk factors include emergency cesarean section, prolonged membrane rupture, prolonged labor, and diffuse difficult vaginal childbirth.
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deaths associated with genital tract sepsis per 100,000 pregnancies was 0.40–0.85. In 2003–2005, genital tract sepsis accounted for 14% of direct causes of maternal death.
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in killing women of childbearing age. A rough estimate is that about 250,000–500,000 died from puerperal fever in the 18th and 19th centuries in England and Wales alone.
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mother and younger sister perished from this condition, explaining the character's animosity towards his nephew Fred and also his poor relationship with his own father.
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Hospitals for childbirth became common in the 17th century in many European cities. These "lying-in" hospitals were established at a time when there was no knowledge of
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Management: multiple agent IV antibiotics to cover polymicrobial organisms: clindamycin, gentamicin, addition of ampicillin if no response, no cultures are necessary.
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solution and changes of clothing for obstetric attendants "to prevent the practitioner becoming a vehicle of contagion and death between one patient and another."
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of the infecting organism, the resistance of the invaded tissues, and the general health of the woman. Organisms commonly producing this infection are
745:. The number of maternal deaths in the United States is about 13 in 100,000. They make up about 11% of pregnancy-related deaths in the United States. 3305: 1212: 891:, London, wrote in 1842: "Wherever puerperal fever is rife, or when a practitioner has attended any one instance of it, he should use most diligent 546: 776:
that women in childbed were prone to fevers, the distinct name, "puerperal fever" appears in historical records only from the early 18th century.
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The debate about when this term first emerged is presented by Irvine Loudon, The tragedy of childbed fever, Oxford University Press, 2000, p. 8.
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From the 1600s through the mid-to-late 1800s, the majority of childbed fever cases were caused by the doctors themselves. With no knowledge of
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and gentamicin in those who have had a C-section. In those who are not improving with appropriate treatment, other complications such as an
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handwash in 1847 marked by vertical line. Rates for Dublin maternity hospital, which had no pathological anatomy, is shown for comparison (
791:. Another reason appears to be a lessening of the virulence or invasiveness of Streptococcus pyogenes. This organism is also the cause of 277:
In 2015, about 11.8 million maternal infections occurred. In the developed world about 1% to 2% develop uterine infections following
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Colebrook, L; Kenny, M (June 6, 1936). "Treatment of Human Puerperal Infections, and of Experimental Infections in Mice, with Prontosil".
1458: 1353: 1692: 952: 1922: 392:, which flourish in devitalized tissues such as may be present after long and injurious labour and unskilled instrumental delivery; 2038: 1899: 2943: 2910: 2471: 1935: 1884: 1854: 1731: 1489: 1452: 1376: 1347: 1198: 1156: 857:
noticed that women giving birth at home had a much lower incidence of childbed fever than those giving birth in the doctor's
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that Semmelweis moved from Vienna and, following a breakdown, was eventually committed to a mental asylum, where he died.
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On the Nature, Signs, and Treatment of Childbed Fevers: In a Series of Letters Addressed to the Students of His Class
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Management: antibiotics for cellulitis, open and drain wound, saline-soaked packing twice a day, secondary closure.
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decreased death from the disease in the First Obstetrical Clinic of Vienna from nearly 20% to 2% through the use of
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Elite status was no protection against postpartum infections, as the deaths of several English queens attest.
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has a large bare surface, which is prone to infection. Infection may be limited to the cavity and wall of her
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Oral temperature of 38 °C (100.4 °F) or more on any two of the first ten days postpartum. (USJCMW)
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Due to the risks following caesarean section, it is recommended that all women receive a preventive dose of
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Management: IV heparin for 7–10 days at rates sufficient to prolong the PTT to double the baseline values.
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in Vienna in 1823 (vertical line) was correlated to the incidence of fatal childbed fever there. Onset of
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among others. Most infections involve a number of types of bacteria. Diagnosis is rarely helped by
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greater than 38.0 °C (100.4 °F), chills, lower abdominal pain, and possibly bad-smelling
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National Center for Case Study Teaching in Science, December 8, 1999 (revised October 27, 2003).
2424: 2318: 1481: 3366: 3340: 3118: 2938: 2933: 2905: 2882: 2782: 2109:""The contagiousness of childbed fever": a short history of puerperal sepsis and its treatment" 1083: 924: 537:), is no longer favored as a diagnostic category. Instead, contemporary terminology specifies: 368: 179:. It usually occurs after the first 24 hours and within the first ten days following delivery. 50: 1721: 1442: 1337: 846: 708:: persistent wide fever swings despite antibiotics, usually normal abdominal or pelvic exams. 3325: 2777: 2237:"The contagiousness of childbed fever: a short history of puerperal sepsis and its treatment" 2165: 1018: 203: 1746: 1002:, died of puerperal fever one week after giving birth to a daughter, who also died. Her son 3335: 3204: 3099: 2920: 2895: 999: 862: 812: 319: 294: 1505:
Anderson BL (April 2014). "Puerperal group A streptococcal infection: beyond Semmelweis".
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Puerperal fever, childbed fever, maternal sepsis, maternal infection, puerperal infections
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Semmelweis was not the only doctor ignored after sounding a warning about this issue: in
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antibiotics are recommended. Common antibiotics include a combination of ampicillin and
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Wyklicky H, Skopec M (1983). "Ignaz Philipp Semmelweis, the prophet of bacteriology".
1409: 1301: 1249: 861:. His investigation discovered that washing hands with an antiseptic, in this case a 564:(uncontrolled and uncontained multiplication of microbes throughout the blood stream). 3250: 3222: 3182: 3177: 3112: 2986: 2787: 2762: 2730: 2585: 2556: 2527: 2467: 2398: 2159: 2128: 2081: 2006: 1988: 1931: 1880: 1850: 1795: 1727: 1640: 1579: 1522: 1485: 1448: 1423: 1372: 1343: 1315: 1263: 1232:
GBD 2015 Disease and Injury Incidence and Prevalence Collaborators (8 October 2016).
1204: 1194: 1152: 1066: 995: 966: 944: 742: 603: 459: 286: 199: 176: 94: 59: 2643: 2539: 2410: 2140: 2093: 1822:"WHO recommendations for prevention and treatment of maternal peripartum infections" 1807: 1534: 1391: 1283: 783:. The decline may be partly attributed to improved environmental conditions, better 3133: 3072: 2804: 2577: 2568:
Calhoun BC, Brost B (June 1995). "Emergency management of sudden puerperal fever".
2519: 2390: 2120: 2073: 1996: 1980: 1787: 1569: 1561: 1514: 1413: 1405: 1305: 1297: 1253: 1245: 1071: 1046: 936: 854: 808: 803: 492: 488: 394: 362:(inflammation of the abdominal lining). The severity of the illness depends on the 278: 219: 102: 2381:
Raju TN (1999). "Ignác Semmelweis and the etiology of fetal and neonatal sepsis".
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WHO recommendations for prevention and treatment of maternal peripartum infections
947:, died of sepsis after accidentally cutting his hand while performing an autopsy. 3288: 3255: 3044: 3029: 2809: 2654: 2431: 2287: 2243: 1906: 1791: 1662: 1606: 1518: 1061: 1050: 692: 470: 435: 227: 2510:
Chaim W, Burstein E (August 2003). "Postpartum infection treatments: a review".
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French L (August 2003). "Prevention and treatment of postpartum endometritis".
1011: 858: 734: 621: 2523: 2077: 54:(red-stained spheres) is responsible for many cases of severe puerperal fever. 3425: 3265: 3235: 2968: 2851: 1992: 1918: 977: 959: 828: 792: 609: 579: 506: 373: 2628: 2209:"Lectures on the principles and practice of physic: Diseases of the abdomen" 686:: moderate fever, exquisite uterine tenderness, minimal abdominal findings. 633:
A number of other conditions can cause fevers following delivery including:
3260: 3194: 2560: 2531: 2402: 2132: 2010: 1799: 1583: 1526: 1427: 1319: 1267: 1208: 1054: 1041: 1036: 1007: 962:, and published his findings in 1860, but his discovery was again ignored. 839: 761: 724:
Management: antibiotics for cellulitis, open and drain abscess if present.
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Management: pulmonary exercises, ambulation (deep breathing and walking).
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of any part of the genital tract. By whatever portal, they can invade the
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The Global Incidence of Puerperal Sepsis Protocol for a Systematic Review
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GBD 2013 Mortality and Causes of Death Collaborators (17 December 2014).
1367:"Cover of Hacker & Moore's Essentials of Obstetrics and Gynecology". 896: 788: 784: 657: 642: 615: 597: 591: 550: 478: 451: 431: 359: 343: 339: 327: 290: 282: 267: 259: 243: 168: 120: 89: 41: 2611: 939:
was appointed assistant lecturer in the First Obstetric Division of the
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is a polymicrobial infection. It frequently includes organisms such as
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GBD 2015 Mortality and Causes of Death Collaborators (8 October 2016).
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The death rate for women giving birth decreased in the 20th century in
757: 585: 573: 443: 381: 355: 335: 263: 254: 250: 239: 164: 64: 2277: 1151:(24th ed.). McGraw-Hill Professional. 2014. pp. Chapter 37. 2863: 2722: 2673: 1629:"Bacteriologic Findings of Post-Cesarian Endometritis in Adolescents" 970: 923:
Holmes' conclusions were ridiculed by many contemporaries, including
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Management: antibiotics as per culture sensitivity (cephalosporine).
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Loudon I. "Deaths in childbed from the eighteenth century to 1935".
560:(contained multiplication of microbes) or possibly life-threatening 442:. Septic risk factors for each condition are listed in order of the 2757: 900: 874: 816: 714: 696: 502: 385: 331: 215: 110: 2039:"The Childbed Fever Mystery and the Meaning of Medical Journalism" 495:, prolonged labor, and multiple vaginal examinations during labor. 230:
may be required. Other causes of fever following delivery include
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Although it had been recognized from as early as the time of the
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PPD 1–2: urinary tract infections risk factors include multiple
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The first recorded epidemic of puerperal fever occurred at the
561: 358:(inflammation of connective tissue), and pelvic or generalized 351: 323: 183: 2336:(1983). "Disastrous Motherhood: Tales from the Vienna Wards". 3025: 2996: 2829: 718: 306: 172: 2964:
Pruritic urticarial papules and plaques of pregnancy (PUPPP)
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Hacker & Moore's essentials of obstetrics and gynecology
660:: mild to moderate fever, no changes or mild rales on chest 1747:
Definition of "infection" from several medical dictionaries
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Fever, lower abdominal pain, bad-smelling vaginal discharge
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Childbed fever. A scientific biography of Ignaz Semmelweis
2317:. Philadelphia, Pennsylvania: Blanchard and Lea. p.  1550:"Medicine in stamps-Ignaz Semmelweis and Puerperal Fever" 418:
Causes (listed in order of decreasing frequency) include
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Basetti S, Hodgson J, Rawson TM, Majeed A (2017-08-11).
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PPD 4–5: wound infection risk factors include emergency
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Journal of the Turkish German Gynecological Association
1371:(6 ed.). Elsevier Canada. 2015. pp. 276–290. 748:
In the United Kingdom from 1985 to 2005, the number of
2357:. London, England: Cassell and Company, Ltd. pp.  2161:
A Treatise on the Epidemic Puerperal Fever of Aberdeen
695:: persistent spiking fever despite antibiotics, wound 202:(C-section), the presence of certain bacteria such as 3432:
Pathology of pregnancy, childbirth and the puerperium
2459: 1776:"Breast Pain: Engorgement, Nipple Pain, and Mastitis" 1723:
Diagnostic Gynecologic and Obstetric Pathology E-Book
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presented evidence to demonstrate that the advent of
553:(inflammation of the membrane lining of the abdomen). 226:
of the vagina or blood. In those who do not improve,
2601: 2365: 2174: 831:, doctors did not believe hand washing was needed. 446:day (PPD) on which the condition generally occurs. 2570:Obstetrics and Gynecology Clinics of North America 2351:Treves F (1923). "Ch. 2: The Old Receiving Room". 2326: 2164:. London, England: G.G. and J. Robinson. pp.  1969:"Scarlet fever: a guide for general practitioners" 1473: 798: 545:(inflammation of the inner lining of the uterus), 3306:Childbirth-related post-traumatic stress disorder 1548:Ataman AD, Vatanoğlu-Lutz EE, Yıldırım G (2013). 3423: 2057: 2425:"Childbed fever: a nineteenth-century mystery," 2340:. London: Hutchinson & Co. pp. 43–46 . 1045:. Other notables include African-American poet 958:He did the same work in St. Rochus hospital in 549:(inflammation of the veins of the uterus), and 2100: 2063: 1193:. World Health Organization. 2015. p. 1. 2706: 2509: 2261:The New England Quarterly Journal of Medicine 2184:. www.general-anaesthesia.com. Archived from 2182:"Treatise on the Epidemic of Puerperal Fever" 1335: 1180: 1178: 1176: 1174: 1172: 1170: 1168: 2567: 2271: 1844: 1719: 1227: 1225: 556:the severity of the infection: less serious 238:, infections of an abdominal incision or an 2254: 1930:. Oxford University Press, USA. p. 6. 1595: 1593: 1279: 1277: 871:Treatise on the Epidemic of Puerperal Fever 2713: 2699: 2257:"On the contagiousness of puerperal fever" 1693:Centers for Disease Control and Prevention 1165: 40: 2000: 1726:. Elsevier Health Sciences. p. 430. 1573: 1417: 1331: 1329: 1309: 1257: 1222: 1086:, a traditional practice after childbirth 628: 595:, and may also include organisms such as 182:The most common infection is that of the 2546: 2466:. Elsevier Health Sciences. p. 54. 2354:The Elephant Man and Other Reminiscences 2106: 1626: 1590: 1504: 1440: 1274: 1142: 1140: 1138: 1136: 1134: 1132: 1130: 1128: 1126: 1124: 1122: 1120: 802: 505:risk factors include nipple trauma from 1900:CEMACH: Saving Mothers' Lives 2003–2005 1849:. Transaction Publishers. p. 100. 1447:. New Delhi: Jaypee Bros. p. 153. 1118: 1116: 1114: 1112: 1110: 1108: 1106: 1104: 1102: 1100: 1049:(1784), British housekeeping authority 1017:Suzanne Barnard, mother of philosopher 171:. Signs and symptoms usually include a 3424: 2417: 2350: 2332: 2206: 2157: 2036: 1917: 1773: 1471: 1385: 1360: 1326: 1035:, died ten days after giving birth to 980:and hence a cure for puerperal fever. 887:(1792–1882), Professor of Medicine at 645:and surgical incisions, among others. 404:(inhabitants of the lower bowel); and 2944:Intrahepatic cholestasis of pregnancy 2911:Intrahepatic cholestasis of pregnancy 2694: 2310: 2280:The Contagiousness of Puerperal Fever 1869: 1758: 1701:from the original on 22 February 2016 917:The Contagiousness of Puerperal Fever 305:Signs and symptoms usually include a 300: 3010:Pregnancy-induced hypercoagulability 2380: 2374: 1667:The Lecturio Medical Concept Library 1097: 990:List of women who died in childbirth 906: 823:). His efforts were futile, however. 677:tenderness, positive urine culture. 84:Typically multiple types of bacteria 1761:Blueprint Obstetrics and Gynecology 518:Puerperal fever is diagnosed with: 326:, or it may spread beyond to cause 13: 2959:Pruritic folliculitis of pregnancy 2503: 2125:10.5694/j.1326-5377.2002.tb05004.x 1780:Clinical Obstetrics and Gynecology 1720:Crum CP, Lee KR, Nucci MR (2011). 1032:Vindication of the Rights of Woman 717:: unilateral, localized erythema, 541:the specific target of infection: 14: 3453: 3217:Pain management during childbirth 3144:Twin-to-twin transfusion syndrome 2597: 2512:Expert Opinion on Pharmacotherapy 2235:The Medical Journal of Australia. 1339:DC Dutta's Textbook of Obstetrics 1057:in 1916 died of puerperal fever. 1006:had two wives who died this way, 529:Puerperal fever (from the Latin 186:and surrounding tissues known as 3403: 3402: 3389:Sexual activity during pregnancy 2460:Sue Bale, Vanessa Jones (2006). 2147:from the original on 2006-12-03. 2113:The Medical Journal of Australia 1834:from the original on 2016-03-06. 1651:from the original on 2013-11-03. 1461:from the original on 2016-03-04. 1356:from the original on 2015-12-08. 1218:from the original on 2016-02-07. 983: 376:(inhabitants of the skin and of 2486: 2453: 2437: 2344: 2304: 2292: 2248: 2227: 2200: 2151: 2030: 2017: 1960: 1951: 1911: 1893: 1863: 1838: 1814: 1767: 1752: 1740: 1713: 1680: 1655: 1620: 1611: 1541: 1498: 1342:. JP Medical Ltd. p. 432. 727: 699:or fluctuance, wound drainage. 413: 2891:Acute fatty liver of pregnancy 2549:Current Women's Health Reports 1973:London Journal of Primary Care 1465: 1444:Manual of perinatal infections 1434: 706:Septic pelvic thrombophlebitis 440:septic pelvic thrombophlebitis 266:following vaginal delivery or 208:premature rupture of membranes 99:premature rupture of membranes 1: 3093:Prelabor rupture of membranes 2582:10.1016/S0889-8545(21)00185-6 1985:10.1080/17571472.2017.1365677 1924:The Tragedy of Childbed Fever 1845:Carter KC, Carter BR (2005). 1480:. New York: Dekker. pp.  1410:10.1016/S0140-6736(14)61682-2 1302:10.1016/s0140-6736(16)31012-1 1250:10.1016/S0140-6736(16)31678-6 1090: 873:(1795), ex-naval surgeon and 648: 3372:Systemic lupus erythematosus 3023:Maternal care related to the 3005:Gestational thrombocytopenia 2371:Gordon, Richard (1983) p. 44 2207:Watson (February 18, 1842). 1792:10.1097/GRF.0000000000000153 1519:10.1097/aog.0000000000000175 513: 477:during labor, and untreated 318:After childbirth, a woman's 7: 3173:Cephalopelvic disproportion 1774:Berens PD (December 2015). 1077: 10: 3458: 3437:Health issues in pregnancy 3284:Breastfeeding difficulties 3083:Constriction ring syndrome 3057:Braxton Hicks contractions 2213:The London Medical Gazette 2043:McGill Journal of Medicine 1627:Berenson AB (April 1990). 1070:, it is implied that both 987: 767: 338:organisms may also affect 3397: 3354: 3321:Peripartum cardiomyopathy 3311:Pubic symphysis diastasis 3274: 3158: 3022: 2995: 2977: 2919: 2881: 2872: 2828: 2746: 2737: 2664: 2605: 2524:10.1517/14656566.4.8.1297 2496:'s "The Age of Rousseau". 2078:10.1017/S0195941700059762 1749:– Retrieved on 2021-07-07 1688:"Urinary Tract Infection" 1633:Obstetrics and Gynecology 1507:Obstetrics and Gynecology 913:Oliver Wendell Holmes Sr. 760:, and was second only to 313: 161:female reproductive tract 134: 126: 116: 88: 80: 70: 58: 48: 39: 31: 26: 2847:Gestational hypertension 2107:De Costa CM (Nov 2002). 635:urinary tract infections 464:obstructive lung disease 236:urinary tract infections 214:, manual removal of the 3246:Umbilical cord prolapse 3168:Amniotic fluid embolism 2926:dermatoses of pregnancy 2383:Journal of Perinatology 2338:Great Medical Disasters 2278:Oliver Wendell Holmes: 2255:Holmes OW (1842–1843). 1039:, who grew up to write 941:Vienna General Hospital 889:King's College Hospital 673:: high fever, malaise, 671:Urinary tract infection 473:during labor, multiple 424:urinary tract infection 401:Clostridium perfringens 198:. Risk factors include 196:postpartum endometritis 3362:Concomitant conditions 3341:Postpartum thyroiditis 3119:Circumvallate placenta 2939:Impetigo herpetiformis 2934:Gestational pemphigoid 2906:Hyperemesis gravidarum 2839:hypertensive disorders 1879:. CEMACH. p. 97. 1336:Hiralal Konar (2014). 1084:Postpartum confinement 1053:, and American author 973:was effective against 953:Response to Semmelweis 925:Charles Delucena Meigs 895:." Watson recommended 824: 629:Differential diagnosis 390:anaerobic streptococci 369:Streptococcus pyogenes 274:should be considered. 51:Streptococcus pyogenes 3331:Postpartum infections 3326:Postpartum depression 2395:10.1038/sj.jp.7200155 2298:(Holmes, 1842–1843), 1566:10.5152/jtgga.2013.08 1476:A history of medicine 1019:Jean-Jacques Rousseau 806: 799:"The Doctor's Plague" 787:care, and the use of 454:risk factors include 204:group B streptococcus 145:Postpartum infections 27:Postpartum infections 3336:Postpartum psychosis 3205:Obstetrical bleeding 3100:Obstetrical bleeding 2921:Integumentary system 2896:Gestational diabetes 2875:related to pregnancy 2873:Other, predominantly 1947:on 11 February 2012. 1296:(10053): 1459–1544. 1244:(10053): 1545–1602. 929:Sir Frederick Treves 863:calcium hypochlorite 813:pathological anatomy 475:vaginal examinations 295:calcium hypochlorite 155:, are any bacterial 3442:Infectious diseases 3316:Postpartum bleeding 3139:Placental abruption 3124:Monochorionic twins 2954:Prurigo gestationis 2049:(1). Archived from 1441:Walvekar V (2005). 1149:Williams Obstetrics 1037:her second daughter 1027:Mary Wollstonecraft 998:, queen consort of 847:Hôtel-Dieu de Paris 781:developed countries 192:postpartum metritis 3346:Puerperal mastitis 3301:Breast engorgement 3088:Monoamniotic twins 3078:Chorionic hematoma 2665:External resources 2463:Wound care nursing 2430:2009-04-16 at the 2286:2007-02-03 at the 2242:2006-12-03 at the 2119:(11–12): 668–671. 2037:Caplan CE (1995). 1905:2008-05-21 at the 1605:2008-12-17 at the 1472:Magner LN (1992). 1023:Émilie du Châtelet 825: 807:In his 1861 book, 774:Hippocratic corpus 639:breast engorgement 456:general anesthesia 407:Clostridium tetani 334:(afterbirth), but 301:Signs and symptoms 232:breast engorgement 3419: 3418: 3377:Thyroid disorders 3367:Diabetes mellitus 3251:Uterine inversion 3183:Shoulder dystocia 3178:Obstructed labour 3154: 3153: 3018: 3017: 2987:Chorea gravidarum 2763:Ectopic pregnancy 2688: 2687: 2473:978-0-7234-3344-6 2311:Meigs CD (1854). 2158:Gordon A (1795). 1937:978-0-19-820499-2 1886:978-0-9533536-8-2 1856:978-1-4128-0467-7 1733:978-1-4557-0895-6 1697:. 17 April 2015. 1491:978-0-8247-8673-1 1454:978-81-8061-472-9 1404:(9963): 117–171. 1378:978-1-4557-7558-3 1349:978-93-5152-067-2 1200:978-92-4-154936-3 1158:978-0-07-179893-8 1067:A Christmas Carol 996:Elizabeth of York 967:Leonard Colebrook 945:Jakob Kolletschka 907:Hygienic measures 743:caesarean section 460:cigarette smoking 384:, and many other 287:Ignaz Semmelweiss 200:caesarean section 177:vaginal discharge 142: 141: 95:Caesarean section 21:Medical condition 3449: 3406: 3405: 3241:Postmature birth 3229:Placenta accreta 3134:Placenta praevia 3129:Placenta accreta 3073:Chorioamnionitis 2883:Digestive system 2879: 2878: 2805:Fetal resorption 2793:Rudimentary horn 2750:abortive outcome 2744: 2743: 2715: 2708: 2701: 2692: 2691: 2603: 2602: 2593: 2564: 2543: 2497: 2490: 2484: 2483: 2481: 2480: 2457: 2451: 2441: 2435: 2421: 2415: 2414: 2378: 2372: 2369: 2363: 2362: 2348: 2342: 2341: 2330: 2324: 2322: 2308: 2302: 2296: 2290: 2275: 2269: 2268: 2252: 2246: 2231: 2225: 2220: 2204: 2198: 2197: 2195: 2193: 2188:on July 20, 2008 2178: 2172: 2169: 2155: 2149: 2148: 2104: 2098: 2097: 2061: 2055: 2054: 2034: 2028: 2021: 2015: 2014: 2004: 1964: 1958: 1955: 1949: 1948: 1946: 1940:. Archived from 1929: 1921:(9 March 2000). 1915: 1909: 1897: 1891: 1890: 1867: 1861: 1860: 1842: 1836: 1835: 1833: 1826: 1818: 1812: 1811: 1771: 1765: 1764: 1756: 1750: 1744: 1738: 1737: 1717: 1711: 1710: 1708: 1706: 1684: 1678: 1677: 1675: 1673: 1659: 1653: 1652: 1624: 1618: 1617:Carter (2005):98 1615: 1609: 1597: 1588: 1587: 1577: 1545: 1539: 1538: 1502: 1496: 1495: 1479: 1469: 1463: 1462: 1438: 1432: 1431: 1421: 1389: 1383: 1382: 1364: 1358: 1357: 1333: 1324: 1323: 1313: 1281: 1272: 1271: 1261: 1229: 1220: 1219: 1217: 1192: 1182: 1163: 1162: 1144: 1047:Phillis Wheatley 937:Ignaz Semmelweis 879:Alexander Gordon 855:Ignaz Semmelweis 809:Ignaz Semmelweis 535:male child (boy) 493:membrane rupture 489:cesarean section 395:Escherichia coli 388:eruptions); the 279:vaginal delivery 220:prolonged labour 188:puerperal sepsis 147:, also known as 103:prolonged labour 44: 24: 23: 3457: 3456: 3452: 3451: 3450: 3448: 3447: 3446: 3422: 3421: 3420: 3415: 3393: 3350: 3294:Cracked nipples 3289:Low milk supply 3270: 3256:Uterine rupture 3150: 3045:Oligohydramnios 3030:amniotic cavity 3024: 3014: 2991: 2973: 2924: 2915: 2874: 2868: 2837: 2824: 2810:Molar pregnancy 2749: 2733: 2719: 2689: 2684: 2683: 2660: 2659: 2614: 2600: 2518:(8): 1297–313. 2506: 2504:Further reading 2501: 2500: 2491: 2487: 2478: 2476: 2474: 2458: 2454: 2450:(1): 1279–1286. 2442: 2438: 2432:Wayback Machine 2423:Christa Colyer. 2422: 2418: 2379: 2375: 2370: 2366: 2349: 2345: 2331: 2327: 2309: 2305: 2297: 2293: 2288:Wayback Machine 2276: 2272: 2253: 2249: 2244:Wayback Machine 2232: 2228: 2205: 2201: 2191: 2189: 2180: 2179: 2175: 2156: 2152: 2105: 2101: 2062: 2058: 2035: 2031: 2022: 2018: 1965: 1961: 1956: 1952: 1944: 1938: 1927: 1916: 1912: 1907:Wayback Machine 1898: 1894: 1887: 1868: 1864: 1857: 1843: 1839: 1831: 1824: 1820: 1819: 1815: 1772: 1768: 1757: 1753: 1745: 1741: 1734: 1718: 1714: 1704: 1702: 1686: 1685: 1681: 1671: 1669: 1661: 1660: 1656: 1625: 1621: 1616: 1612: 1607:Wayback Machine 1598: 1591: 1546: 1542: 1503: 1499: 1492: 1470: 1466: 1455: 1439: 1435: 1390: 1386: 1379: 1366: 1365: 1361: 1350: 1334: 1327: 1282: 1275: 1230: 1223: 1215: 1201: 1190: 1184: 1183: 1166: 1159: 1146: 1145: 1098: 1093: 1080: 1062:Charles Dickens 1051:Isabella Beeton 992: 986: 909: 801: 770: 735:maternal deaths 730: 693:Wound infection 651: 631: 516: 471:catheterization 436:wound infection 416: 316: 303: 228:medical imaging 206:in the vagina, 153:puerperal fever 22: 17: 12: 11: 5: 3455: 3445: 3444: 3439: 3434: 3417: 3416: 3414: 3413: 3398: 3395: 3394: 3392: 3391: 3386: 3384:Maternal death 3381: 3380: 3379: 3374: 3369: 3358: 3356: 3352: 3351: 3349: 3348: 3343: 3338: 3333: 3328: 3323: 3318: 3313: 3308: 3303: 3298: 3297: 3296: 3291: 3280: 3278: 3272: 3271: 3269: 3268: 3263: 3258: 3253: 3248: 3243: 3238: 3233: 3232: 3231: 3219: 3214: 3213: 3212: 3202: 3197: 3192: 3190:Fetal distress 3187: 3186: 3185: 3175: 3170: 3164: 3162: 3156: 3155: 3152: 3151: 3149: 3148: 3147: 3146: 3141: 3136: 3131: 3126: 3121: 3109: 3108: 3107: 3097: 3096: 3095: 3090: 3085: 3080: 3075: 3059: 3054: 3053: 3052: 3050:Polyhydramnios 3047: 3039:amniotic fluid 3034: 3032: 3020: 3019: 3016: 3015: 3013: 3012: 3007: 3001: 2999: 2993: 2992: 2990: 2989: 2983: 2981: 2979:Nervous system 2975: 2974: 2972: 2971: 2966: 2961: 2956: 2951: 2946: 2941: 2936: 2930: 2928: 2917: 2916: 2914: 2913: 2908: 2903: 2898: 2893: 2887: 2885: 2876: 2870: 2869: 2867: 2866: 2861: 2860: 2859: 2857:HELLP syndrome 2849: 2843: 2841: 2826: 2825: 2823: 2822: 2817: 2812: 2807: 2802: 2797: 2796: 2795: 2790: 2785: 2780: 2775: 2770: 2760: 2754: 2752: 2748:Pregnancy with 2741: 2735: 2734: 2718: 2717: 2710: 2703: 2695: 2686: 2685: 2682: 2681: 2679:article/796892 2669: 2668: 2666: 2662: 2661: 2658: 2657: 2646: 2631: 2615: 2610: 2609: 2607: 2606:Classification 2599: 2598:External links 2596: 2595: 2594: 2565: 2544: 2505: 2502: 2499: 2498: 2485: 2472: 2452: 2436: 2416: 2389:(4): 307–310. 2373: 2364: 2343: 2325: 2303: 2291: 2270: 2247: 2226: 2199: 2173: 2150: 2099: 2072:(5): 367–370. 2066:Infect Control 2056: 2053:on 2012-07-07. 2029: 2027:1986; 30: 1–41 2016: 1959: 1950: 1936: 1910: 1892: 1885: 1873:, ed. (2007). 1862: 1855: 1837: 1813: 1766: 1751: 1739: 1732: 1712: 1679: 1654: 1639:(4): 627–629. 1619: 1610: 1589: 1540: 1513:(4): 874–882. 1497: 1490: 1464: 1453: 1433: 1384: 1377: 1359: 1348: 1325: 1273: 1221: 1199: 1164: 1157: 1095: 1094: 1092: 1089: 1088: 1087: 1079: 1076: 1025:died in 1749. 1012:Catherine Parr 985: 982: 908: 905: 859:maternity ward 800: 797: 769: 766: 729: 726: 721:, tenderness. 675:costovertebral 650: 647: 630: 627: 622:Staphylococcus 566: 565: 554: 547:metrophlebitis 527: 526: 523: 515: 512: 511: 510: 499: 496: 485: 482: 467: 415: 412: 315: 312: 302: 299: 149:childbed fever 140: 139: 136: 132: 131: 128: 124: 123: 118: 114: 113: 92: 86: 85: 82: 78: 77: 74: 68: 67: 62: 56: 55: 46: 45: 37: 36: 33: 29: 28: 20: 15: 9: 6: 4: 3: 2: 3454: 3443: 3440: 3438: 3435: 3433: 3430: 3429: 3427: 3412: 3411: 3407: 3400: 3399: 3396: 3390: 3387: 3385: 3382: 3378: 3375: 3373: 3370: 3368: 3365: 3364: 3363: 3360: 3359: 3357: 3353: 3347: 3344: 3342: 3339: 3337: 3334: 3332: 3329: 3327: 3324: 3322: 3319: 3317: 3314: 3312: 3309: 3307: 3304: 3302: 3299: 3295: 3292: 3290: 3287: 3286: 3285: 3282: 3281: 3279: 3277: 3273: 3267: 3266:Uterine atony 3264: 3262: 3259: 3257: 3254: 3252: 3249: 3247: 3244: 3242: 3239: 3237: 3236:Preterm birth 3234: 3230: 3227: 3226: 3225: 3224: 3220: 3218: 3215: 3211: 3208: 3207: 3206: 3203: 3201: 3198: 3196: 3193: 3191: 3188: 3184: 3181: 3180: 3179: 3176: 3174: 3171: 3169: 3166: 3165: 3163: 3161: 3157: 3145: 3142: 3140: 3137: 3135: 3132: 3130: 3127: 3125: 3122: 3120: 3117: 3116: 3115: 3114: 3110: 3106: 3103: 3102: 3101: 3098: 3094: 3091: 3089: 3086: 3084: 3081: 3079: 3076: 3074: 3071: 3070: 3069: 3068: 3064: 3060: 3058: 3055: 3051: 3048: 3046: 3043: 3042: 3041: 3040: 3036: 3035: 3033: 3031: 3027: 3021: 3011: 3008: 3006: 3003: 3002: 3000: 2998: 2994: 2988: 2985: 2984: 2982: 2980: 2976: 2970: 2969:Stretch marks 2967: 2965: 2962: 2960: 2957: 2955: 2952: 2950: 2947: 2945: 2942: 2940: 2937: 2935: 2932: 2931: 2929: 2927: 2922: 2918: 2912: 2909: 2907: 2904: 2902: 2899: 2897: 2894: 2892: 2889: 2888: 2886: 2884: 2880: 2877: 2871: 2865: 2862: 2858: 2855: 2854: 2853: 2852:Pre-eclampsia 2850: 2848: 2845: 2844: 2842: 2840: 2835: 2831: 2827: 2821: 2818: 2816: 2813: 2811: 2808: 2806: 2803: 2801: 2798: 2794: 2791: 2789: 2786: 2784: 2781: 2779: 2776: 2774: 2771: 2769: 2766: 2765: 2764: 2761: 2759: 2756: 2755: 2753: 2751: 2745: 2742: 2740: 2736: 2732: 2728: 2724: 2721:Pathology of 2716: 2711: 2709: 2704: 2702: 2697: 2696: 2693: 2680: 2676: 2675: 2671: 2670: 2667: 2663: 2656: 2652: 2651: 2647: 2645: 2641: 2640: 2636: 2632: 2630: 2626: 2625: 2621: 2617: 2616: 2613: 2608: 2604: 2591: 2587: 2583: 2579: 2576:(2): 357–67. 2575: 2571: 2566: 2562: 2558: 2554: 2550: 2545: 2541: 2537: 2533: 2529: 2525: 2521: 2517: 2513: 2508: 2507: 2495: 2489: 2475: 2469: 2465: 2464: 2456: 2449: 2446: 2440: 2433: 2429: 2426: 2420: 2412: 2408: 2404: 2400: 2396: 2392: 2388: 2384: 2377: 2368: 2360: 2356: 2355: 2347: 2339: 2335: 2329: 2320: 2316: 2315: 2307: 2301: 2295: 2289: 2285: 2282: 2281: 2274: 2266: 2262: 2258: 2251: 2245: 2241: 2238: 2236: 2230: 2223: 2218: 2214: 2210: 2203: 2192:September 15, 2187: 2183: 2177: 2167: 2163: 2162: 2154: 2146: 2142: 2138: 2134: 2130: 2126: 2122: 2118: 2114: 2110: 2103: 2095: 2091: 2087: 2083: 2079: 2075: 2071: 2067: 2060: 2052: 2048: 2044: 2040: 2033: 2026: 2020: 2012: 2008: 2003: 1998: 1994: 1990: 1986: 1982: 1978: 1974: 1970: 1963: 1954: 1943: 1939: 1933: 1926: 1925: 1920: 1914: 1908: 1904: 1901: 1896: 1888: 1882: 1878: 1877: 1872: 1866: 1858: 1852: 1848: 1841: 1830: 1823: 1817: 1809: 1805: 1801: 1797: 1793: 1789: 1786:(4): 902–14. 1785: 1781: 1777: 1770: 1762: 1759:Callaghan T. 1755: 1748: 1743: 1735: 1729: 1725: 1724: 1716: 1700: 1696: 1694: 1689: 1683: 1668: 1664: 1663:"Atelectasis" 1658: 1650: 1646: 1642: 1638: 1634: 1630: 1623: 1614: 1608: 1604: 1601: 1596: 1594: 1585: 1581: 1576: 1571: 1567: 1563: 1559: 1555: 1551: 1544: 1536: 1532: 1528: 1524: 1520: 1516: 1512: 1508: 1501: 1493: 1487: 1483: 1478: 1477: 1468: 1460: 1456: 1450: 1446: 1445: 1437: 1429: 1425: 1420: 1415: 1411: 1407: 1403: 1399: 1395: 1388: 1380: 1374: 1370: 1363: 1355: 1351: 1345: 1341: 1340: 1332: 1330: 1321: 1317: 1312: 1307: 1303: 1299: 1295: 1291: 1287: 1280: 1278: 1269: 1265: 1260: 1255: 1251: 1247: 1243: 1239: 1235: 1228: 1226: 1214: 1210: 1206: 1202: 1196: 1189: 1188: 1181: 1179: 1177: 1175: 1173: 1171: 1169: 1160: 1154: 1150: 1143: 1141: 1139: 1137: 1135: 1133: 1131: 1129: 1127: 1125: 1123: 1121: 1119: 1117: 1115: 1113: 1111: 1109: 1107: 1105: 1103: 1101: 1096: 1085: 1082: 1081: 1075: 1073: 1069: 1068: 1063: 1058: 1056: 1052: 1048: 1044: 1043: 1038: 1034: 1033: 1028: 1024: 1020: 1015: 1013: 1009: 1005: 1001: 997: 991: 984:Notable cases 981: 979: 978:streptococcus 976: 972: 968: 963: 961: 960:Pest, Hungary 956: 954: 948: 946: 942: 938: 933: 930: 926: 921: 918: 914: 904: 902: 898: 894: 890: 886: 885:Thomas Watson 882: 880: 877:obstetrician 876: 872: 867: 864: 860: 856: 853:In the 1800s 851: 848: 843: 841: 837: 832: 830: 822: 818: 814: 810: 805: 796: 794: 793:scarlet fever 790: 786: 782: 777: 775: 765: 763: 759: 753: 751: 746: 744: 738: 736: 725: 722: 720: 716: 712: 709: 707: 703: 700: 698: 694: 690: 687: 685: 681: 678: 676: 672: 668: 665: 663: 659: 655: 646: 644: 640: 636: 626: 624: 623: 618: 617: 612: 611: 610:Lactobacillus 606: 605: 600: 599: 594: 593: 588: 587: 582: 581: 580:Streptococcus 576: 575: 570: 563: 559: 555: 552: 548: 544: 540: 539: 538: 536: 532: 524: 521: 520: 519: 508: 507:breastfeeding 504: 500: 497: 494: 490: 486: 483: 480: 476: 472: 468: 465: 461: 457: 453: 449: 448: 447: 445: 441: 437: 433: 429: 425: 421: 411: 409: 408: 403: 402: 397: 396: 391: 387: 383: 379: 375: 374:staphylococci 371: 370: 365: 361: 357: 353: 349: 345: 341: 337: 333: 329: 325: 321: 320:genital tract 311: 308: 298: 296: 292: 288: 284: 280: 275: 273: 269: 265: 261: 256: 252: 247: 245: 241: 237: 233: 229: 225: 221: 217: 213: 212:vaginal exams 209: 205: 201: 197: 193: 189: 185: 180: 178: 174: 170: 166: 162: 158: 154: 150: 146: 137: 133: 129: 125: 122: 119: 115: 112: 108: 104: 100: 96: 93: 91: 87: 83: 79: 75: 73: 69: 66: 63: 61: 57: 53: 52: 47: 43: 38: 34: 30: 25: 19: 16:Human disease 3408: 3401: 3330: 3261:Vasa praevia 3221: 3195:Locked twins 3111: 3061: 3037: 2783:Interstitial 2672: 2648: 2633: 2618: 2573: 2569: 2555:(4): 274–9. 2552: 2548: 2515: 2511: 2492:Quoted from 2488: 2477:. 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Index


Streptococcus pyogenes
Specialty
Obstetrics
Symptoms
Risk factors
Caesarean section
premature rupture of membranes
prolonged labour
malnutrition
diabetes
Antibiotics
infections
female reproductive tract
childbirth
miscarriage
fever
vaginal discharge
uterus
caesarean section
group B streptococcus
premature rupture of membranes
vaginal exams
placenta
prolonged labour
culturing
medical imaging
breast engorgement
urinary tract infections
episiotomy

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