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Perisinusoidal space

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57: 29: 246:). The excess extracellular matrix may be cleared as the causative insult subsides and the liver parenchyma regenerates with appropriate macrostructure if injury is limited to the center of the liver lobules; when injury affects entire liver lobules, fibrous septa form, impeding structural restoration and promoting nodule formation ( 160:
components from the sinusoids to be absorbed by the hepatocytes. Fenestration and discontinuity of the endothelium facilitates this transport. The perisinusoidal space also contains
385: 413: 376: โ€“ Histology Learning System at Boston University - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse" 218:(which may arise due to various insults) promotes proliferation of hepatic fibroblasts as well as transformation of stellate cells into 406: 363: 382: โ€“ Histology Learning System at Boston University - "Liver, Gall Bladder, and Pancreas: liver; sinusoids and Kupffer cells" 337: 399: 536: 275: 111: 686: 423: 481: 104: 702: 722: 367: 99: 391: 580: 565: 459: 242:), and impaired substance exchange between sinusoidal blood and hepatocytes (which may result in 745: 474: 439: 265: 526: 469: 243: 161: 379: 373: 238:) which results in increased resistance to blood flow in the sinusoids (which may result in 173: 8: 597: 239: 46: 750: 592: 449: 388:- Comparative Organology at University of California, Davis - "Mammal, liver (EM, Low)" 717: 712: 630: 587: 343: 333: 308: 271: 682: 677: 672: 667: 625: 620: 575: 570: 508: 496: 300: 235: 697: 304: 640: 491: 464: 145: 739: 548: 513: 454: 347: 266:
Robbins, Stanley L.; Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker (1999).
219: 187:, leading to decreased uptake by hepatocytes of nutrients and wastes such as 184: 531: 503: 444: 327: 312: 231: 227: 215: 198: 157: 149: 615: 607: 153: 117: 521: 141: 42: 557: 247: 195: 188: 177: 56: 38: 656: 421: 223: 156:
of hepatocytes extend into this space, allowing proteins and other
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liver with fenestrated endothelial cells. Fenestrae are approx 100
222:. These then secrete extracellular matrix components (various 431: 137: 87: 75: 28: 169: 34: 291:Haubrich WS (2004). "Disse of the space of Disse". 16:Location in liver between hepatocyte and sinusoid 737: 45:. Scanning electron micrograph by Robin Fraser, 325: 407: 386:Anatomy photo: digestive/mammal/liver5/liver7 290: 284: 259: 194:The Space of Disse is named for the German 414: 400: 326:Silbernagl, Stefan; Lang, Florian (2009). 55: 27: 738: 234:) into the perisinusoidal space (i.e. 395: 332:(2nd ed.). Thieme. p. 186. 41:diameter, and the sinusoidal width 5 268:Robbins pathologic basis of disease 214:Hepatic cell injury and consequent 13: 204: 14: 762: 537:Liver sinusoidal endothelial cell 357: 183:This space may be obliterated in 424:liver, pancreas and biliary tree 112:Anatomical terms of microanatomy 329:Color Atlas of Pathophysiology 319: 1: 253: 305:10.1053/j.gastro.2004.10.021 7: 209: 10: 767: 482:Fibrous capsule of Glisson 270:. Philadelphia: Saunders. 655: 606: 556: 547: 430: 380:Histology image: 15204loa 374:Histology image: 22103loa 110: 98: 86: 81: 71: 66: 54: 26: 21: 566:Intrahepatic bile ducts 136:) is a location in the 93:spatium perisinusoideum 364:UIUC Histology Subject 162:hepatic stellate cells 527:Hepatic stellate cell 244:chronic liver failure 216:inflammatory response 61:Basic liver structure 487:Perisinusoidal space 174:fat soluble vitamins 130:perisinusoidal space 22:Perisinusoidal space 598:Common hepatic duct 240:portal hypertension 47:University of Otago 593:Right hepatic duct 450:Ligamentum venosum 148:. It contains the 105:H3.04.05.0.00012 733: 732: 718:Centroacinar cell 713:Pancreatic islets 651: 650: 631:Sphincter of Oddi 588:Left hepatic duct 339:978-3-13-116552-7 126: 125: 121: 758: 687:Uncinate process 626:Ampulla of Vater 621:Common bile duct 576:Canals of Hering 571:Bile canaliculus 554: 553: 509:Lobules of liver 497:Periportal space 416: 409: 402: 393: 392: 352: 351: 323: 317: 316: 293:Gastroenterology 288: 282: 281: 263: 236:hepatic fibrosis 118:edit on Wikidata 115: 59: 31: 19: 18: 766: 765: 761: 760: 759: 757: 756: 755: 736: 735: 734: 729: 647: 602: 543: 426: 422:Anatomy of the 420: 360: 355: 340: 324: 320: 289: 285: 278: 264: 260: 256: 212: 207: 205:Pathophysiology 168:), which store 164:(also known as 122: 62: 50: 17: 12: 11: 5: 764: 754: 753: 748: 731: 730: 728: 727: 726: 725: 720: 715: 707: 706: 705: 700: 692: 691: 690: 680: 675: 670: 661: 659: 653: 652: 649: 648: 646: 645: 644: 643: 641:Cholecystocyte 635: 634: 633: 623: 618: 612: 610: 604: 603: 601: 600: 595: 590: 585: 584: 583: 578: 573: 562: 560: 551: 545: 544: 542: 541: 540: 539: 534: 529: 524: 516: 511: 506: 501: 500: 499: 492:Liver sinusoid 489: 484: 479: 478: 477: 472: 465:Lobes of liver 462: 460:Round ligament 457: 452: 447: 442: 436: 434: 428: 427: 419: 418: 411: 404: 396: 390: 389: 383: 377: 371: 359: 358:External links 356: 354: 353: 338: 318: 283: 276: 257: 255: 252: 220:myofibroblasts 211: 208: 206: 203: 134:space of Disse 124: 123: 114: 108: 107: 102: 96: 95: 90: 84: 83: 79: 78: 73: 69: 68: 64: 63: 60: 52: 51: 33:Sinusoid of a 32: 24: 23: 15: 9: 6: 4: 3: 2: 763: 752: 749: 747: 746:Liver anatomy 744: 743: 741: 724: 723:Stellate cell 721: 719: 716: 714: 711: 710: 709:Microanatomy 708: 704: 701: 699: 696: 695: 693: 688: 684: 681: 679: 676: 674: 671: 669: 666: 665: 663: 662: 660: 658: 654: 642: 639: 638: 636: 632: 629: 628: 627: 624: 622: 619: 617: 614: 613: 611: 609: 605: 599: 596: 594: 591: 589: 586: 582: 579: 577: 574: 572: 569: 568: 567: 564: 563: 561: 559: 555: 552: 550: 549:Biliary tract 546: 538: 535: 533: 530: 528: 525: 523: 520: 519: 518:Microanatomy 517: 515: 514:Liver segment 512: 510: 507: 505: 502: 498: 495: 494: 493: 490: 488: 485: 483: 480: 476: 473: 471: 468: 467: 466: 463: 461: 458: 456: 455:Porta hepatis 453: 451: 448: 446: 443: 441: 438: 437: 435: 433: 429: 425: 417: 412: 410: 405: 403: 398: 397: 394: 387: 384: 381: 378: 375: 372: 370: 369: 365: 362: 361: 349: 345: 341: 335: 331: 330: 322: 314: 310: 306: 302: 298: 294: 287: 279: 277:0-7216-7335-X 273: 269: 262: 258: 251: 249: 245: 241: 237: 233: 232:glycoproteins 229: 228:proteoglycans 225: 221: 217: 202: 201:(1852โ€“1912). 200: 197: 192: 190: 186: 185:liver disease 181: 179: 175: 171: 167: 163: 159: 155: 151: 147: 143: 139: 135: 131: 119: 113: 109: 106: 103: 101: 97: 94: 91: 89: 85: 80: 77: 74: 70: 65: 58: 53: 48: 44: 40: 36: 30: 25: 20: 581:Interlobular 532:Kupffer cell 504:Portal triad 486: 445:Cantlie line 366: 328: 321: 296: 292: 286: 267: 261: 213: 199:Joseph Disse 193: 182: 165: 150:blood plasma 133: 129: 127: 92: 616:Cystic duct 608:Gallbladder 299:(6): 1684. 250:) instead. 176:including 82:Identifiers 740:Categories 558:Bile ducts 522:Hepatocyte 254:References 154:Microvilli 142:hepatocyte 140:between a 751:Histology 703:accessory 440:Bare area 348:439472713 248:cirrhosis 224:collagens 196:anatomist 189:bilirubin 178:vitamin A 166:Ito cells 657:Pancreas 475:Quadrate 313:15578505 210:Fibrosis 146:sinusoid 72:Location 470:Caudate 67:Details 694:Ducts 664:Gross 637:Cells 346:  336:  311:  274:  230:, and 158:plasma 144:and a 432:Liver 138:liver 116:[ 88:Latin 76:Liver 698:main 683:Head 678:Neck 673:Body 668:Tail 368:1317 344:OCLC 334:ISBN 309:PMID 272:ISBN 132:(or 128:The 301:doi 297:127 180:). 172:or 170:fat 152:. 35:rat 742:: 342:. 307:. 295:. 226:, 191:. 100:TH 43:ยตm 39:nm 689:) 685:( 415:e 408:t 401:v 350:. 315:. 303:: 280:. 120:] 49:.

Index


rat
nm
ยตm
University of Otago

Liver
Latin
TH
H3.04.05.0.00012
Anatomical terms of microanatomy
edit on Wikidata
liver
hepatocyte
sinusoid
blood plasma
Microvilli
plasma
hepatic stellate cells
fat
fat soluble vitamins
vitamin A
liver disease
bilirubin
anatomist
Joseph Disse
inflammatory response
myofibroblasts
collagens
proteoglycans

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