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Onychomycosis

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747: 767:) in persons without a confirmed infection is recommended, because of the possible side effects of that treatment. First topical terbinafine medication (MOB-015) was launched in February 2024 in Sweden under the name Terclara. This medication recorded 76% mycological cure rate in two phase 3 studies. The topical property of this medication ensures that typical terbinafine side effects are not present (1000 times lower terbinafine levels in plasma). Roll-out in other countries will continue in the coming years. 867:
the authors say that terbinafine has a relatively benign adverse effect profile, with liver damage very rare, so it makes more sense cost-wise for the dermatologist to prescribe the treatment without doing the PAS test. (Another option would be to prescribe the treatment only if the potassium hydroxide test is positive, but it gives a false negative in about 20% of cases of fungal infection.) On the other hand, as of 2015 the price of topical (non-oral) treatment with
305: 37: 630:(WSO) is caused by fungal invasion of the superficial layers of the nail plate to form "white islands" on the plate. It accounts for around 10 percent of onychomycosis cases. In some cases, WSO is a misdiagnosis of "keratins granulations" which are not a fungus, but a reaction to nail polish that can cause the nails to have a chalky white appearance. A laboratory test should be performed to confirm. 297: 915:
A 2003 survey of diseases of the foot in 16 European countries found onychomycosis to be the most frequent fungal foot infection and estimated its prevalence at 27%. Prevalence was observed to increase with age. In Canada, the prevalence was estimated to be 6.48%. Onychomycosis affects approximately
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Recurrence may occur following treatment, with a 20-25% relapse rate within 2 years of successful treatment. Nail fungus can be painful and cause permanent damage to nails. It may lead to other serious infections if the immune system is suppressed due to medication, diabetes or other conditions. The
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The most common symptom of a fungal nail infection is the nail becoming thickened and discoloured: white, black, yellow or green. As the infection progresses the nail can become brittle, with pieces breaking off or coming away from the toe or finger completely. If left untreated, the skin underneath
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is used first and the PAS test is used only if the KOH test is negative, there is a good chance that the PAS will be done (because of either a true or a false negative with the KOH test). But the terbinafine treatment costs only $ 10 (plus an additional $ 43 for liver function tests). In conclusion
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there was no statistical difference between the clotrimazole and TTO treatment groups in mycologic cure, clinical assessment, or patient subjective assessment of the nails. Although there was an 80% complete cure in the butenafine and TTO group, it was 0% in the TTO group at week 36. Trial design,
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and around the nail can become inflamed and painful. There may also be white or yellow patches on the nailbed or scaly skin next to the nail, and a foul smell. There is usually no pain or other bodily symptoms, unless the disease is severe. People with onychomycosis may experience significant
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Onychomycosis occurs in about 10 percent of the adult population, with older people more frequently affected. Males are affected more often than females. Onychomycosis represents about half of nail disease. It was first determined to be the result of a fungal infection in 1853 by
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longer treatment periods, incorporation into nanocapsules, or combination treatment with other antifungal agents may influence our future use of TTO for onychomycosis, but based on the present data we cannot recommend this treatment in clinical practice.
541:, longer exposure to fungi, nails which grow more slowly and thicken, and reduced immune function increasing susceptibility to infection. Nail fungus tends to affect men more often than women and is associated with a family history of this infection. 2546:
Verma S, Heffernan MP (2008). Superficial fungal infection: Dermatophytosis, onychomycosis, tinea nigra, piedra. In K Wolff et al., eds., Fitzpatrick's Dermatology in General Medicine, 7th ed., vol 2, pp. 1807–1821. New York: McGraw
556:(tinea pedis), minor skin or nail injury, damaged nail, or other infection, and having diabetes, circulation problems, which may also lead to lower peripheral temperatures on hands and feet, or a weakened immune system. 2827: 2812: 1846:"Efficacy and safety of topical terbinafine 10% solution (MOB-015) in the treatment of mild to moderate distal subungual onychomycosis: A randomized, multicenter, double-blind, vehicle-controlled phase 3 study" 811:
Topical ciclopirox results in a cure in 6% to 9% of cases. Ciclopirox when used with terbinafine appears to be better than either agent alone. Although eficonazole, P-3051 (ciclopirox 8% hydrolacquer), and
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risk is most serious for people with diabetes and with immune systems weakened by leukemia or AIDS, or medication after organ transplant. Diabetics have vascular and nerve impairment, and are at risk of
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by mouth is not recommended due to side effects. Oral terbinafine is better tolerated than itraconazole. For superficial white onychomycosis, systemic rather than topical antifungal therapy is advised.
2938: 808:, led to cure rates two or three times better than the next-best topical treatment, ciclopirox. In trials, about 17% of people were cured using efinaconazole, as opposed to 4% of people using placebo. 778:(48% effective). They share characteristics that enhance their effectiveness: prompt penetration of the nail and nail bed, and persistence in the nail for months after discontinuation of therapy. 982:
treatment is to try to heat the nail bed to these temperatures in order to disrupt fungal growth. As of 2013 research into laser treatment seemed promising. There is also ongoing development in
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Gupta AK, Konnikov N, MacDonald P, Rich P, Rodger NW, Edmonds MW, et al. (October 1998). "Prevalence and epidemiology of toenail onychomycosis in diabetic subjects: a multicentre survey".
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Gupta AK, Lynde CW, Jain HC, Sibbald RG, Elewski BE, Daniel CR, et al. (May 1997). "A higher prevalence of onychomycosis in psoriatics compared with non-psoriatics: a multicentre study".
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Other molds more commonly affect people older than 60 years, and their presence in the nail reflects a slight weakening in the nail's ability to defend itself against fungal invasion.
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A person's foot with a fungal nail infection ten weeks into a course of terbinafine oral medication. Note the band of healthy (pink) nail growth behind the remaining infected nails.
280:, but there is no evidence that it works. The condition returns in up to half of cases following treatment. Not using old shoes after treatment may decrease the risk of recurrence. 2931: 2494:
Burzykowski T, Molenberghs G, Abeck D, Haneke E, Hay R, Katsambas A, et al. (December 2003). "High prevalence of foot diseases in Europe: results of the Achilles Project".
552:, wearing socks and shoes that hinder ventilation and do not absorb perspiration, going barefoot in damp public places such as swimming pools, gyms and shower rooms, having 1957:"Nizoral (ketoconazole) Oral Tablets: Drug Safety Communication - Prescribing for Unapproved Uses including Skin and Nail Infections Continues; Linked to Patient Death" 2924: 671:
species invasion of the fingernails, usually occurring in persons who frequently immerse their hands in water. This normally requires the prior damage of the nail by
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Shemer A, Davidovici B, Grunwald MH, Trau H, Amichai B (January 2009). "New criteria for the laboratory diagnosis of nondermatophyte moulds in onychomycosis".
903:, a potentially serious bacterial infection; any relatively minor injury to feet, including a nail fungal infection, can lead to more serious complications. 887: 4611: 1982:
Haugh M, Helou S, Boissel JP, Cribier BJ (July 2002). "Terbinafine in fungal infections of the nails: a meta-analysis of randomized clinical trials".
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Gupta AK, Paquet M (2014). "Efinaconazole 10% nail solution: a new topical treatment with broad antifungal activity for onychomycosis monotherapy".
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Baran R, Faergemann J, Hay RJ (November 2007). "Superficial white onychomycosis--a syndrome with different fungal causes and paths of infection".
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appear more useful than culture or direct KOH examination. To reliably identify nondermatophyte molds, several samples may be necessary.
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problems due to the appearance of the nail, particularly when fingers – which are always visible – rather than toenails are affected.
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is not recommended as a treatment on present data. It was found to irritate the surrounding skin in some trial participants.
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The diagnosis is generally suspected based on the appearance and confirmed by laboratory testing. The four main tests are a
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and nondermatophytic molds are more frequently involved in the tropics and subtropics with a hot and humid climate.
371:. Dermatophytes are the fungi most commonly responsible for onychomycosis in the temperate western countries; while 4698: 4477: 4472: 4179: 3530: 633: 6338: 6049: 4803: 4444: 4391: 4169: 1676: 1658: 627: 580:. The sample examined is generally nail scrapings or clippings. These being from as far up the nail as possible. 325:
that sometimes form as a result of a fungus infection in another part of the body. This could take the form of a
1484:"Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis" 5360: 4174: 3489: 3115: 2255:
Foley K, Gupta AK, Versteeg S, Mays R, Villanueva E, John D, et al. (Cochrane Skin Group) (January 2020).
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Advancing age (usually over the age of 60) is the most common risk factor for onychomycosis due to diminished
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Szepietowski JC, Reich A (July 2009). "Stigmatisation in onychomycosis patients: a population-based study".
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Research suggests that fungi are sensitive to heat, typically 40–60 °C (104–140 °F). The basis of
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Vender, Ronald B.; Lynde, Charles W.; Poulin, Yves (2006). "Prevalence and epidemiology of onychomycosis".
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found the cost for a 48-week efinaconazole course to be $ 178 for a big toe, and $ 89 for a different toe.
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Chi CC, Wang SH, Chou MC (November 2005). "The causative pathogens of onychomycosis in southern Taiwan".
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In many cases of suspected nail fungus there is actually no fungal infection, but only nail deformity.
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Westerberg DP, Voyack MJ (December 2013). "Onychomycosis: Current trends in diagnosis and treatment".
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in an area of the body that is not infected with the fungus. Dermatophytids can be thought of as an
255:. The diagnosis is generally suspected based on the appearance and confirmed by laboratory testing. 6370: 6354: 6168: 6026: 4981: 4543: 4223: 3717: 3363: 3300: 3195: 2842: 2465: 407: 401: 507:
species mainly cause fingernail onychomycosis in people whose hands are often submerged in water.
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Frazier, Winfred Taylor; Santiago-Delgado, Zuleica M.; Kenneth C. Stupka, I. I. (October 2021).
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Kreijkamp-Kaspers S, Hawke K, Guo L, Kerin G, Bell-Syer SE, Magin P, et al. (July 2017).
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medications, either topically or by mouth. Avoiding use of antifungal therapy by mouth (e.g.,
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of the lower leg. A number of different types of fungus can cause onychomycosis, including
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are effective at treating fungal infection of toenails, complete cure rates are low.
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in healthy people, but is found more commonly when the patient is immunocompromised.
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When onychomycosis is due to a dermatophyte infection, it is termed tinea unguium.
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The cost of efinaconazole treatment can be reduced to $ 65 per 1-month dose using
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may be affected, but it is more common for toenails. Complications may include
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According to a 2015 study, the cost in the United States of testing with the
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Medications that may be taken by mouth include terbinafine (76% effective),
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Tosti, Antonella (31 Jul 2018). Elston, Dirk M; Vinson, Richard P (eds.).
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is unclear as the evidence is of low quality and varies by type of laser.
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is fungal penetration of the newly formed nail plate through the proximal
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involved in onychomycosis. Other dermatophytes that may be involved are
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taken by mouth appears to be the most effective but is associated with
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was $ 2307 per nail, so testing is recommended before prescribing it.
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can cause damaged toenails to become thick, discolored & brittle.
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Other conditions that may appear similar to onychomycosis include:
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Rodgers P, Bassler M (February 2001). "Treating onychomycosis".
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Onychomycosis does not necessarily require treatment. The
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White or yellow nail discoloration, thickening of the nail
2211:"A Closer Look At A New Topical Option For Onychomycosis" 1756:
Mikailov A, Cohen J, Joyce C, Mostaghimi A (March 2016).
1981: 1868:"Onychomycosis: pathogenesis, diagnosis, and management" 1249: 4027: 1482:
Velasquez-Agudelo V, Cardona-Arias JA (February 2017).
1427: 1425: 2466:"Table 5, CDR Cost Comparison Table for Onychomycosis" 2254: 1203:"Oral antifungal medication for toenail onychomycosis" 2746: 2640: 1663:"Five Things Physicians and Patients Should Question" 1005: 2794: 2727:"Device-based Therapies for Onychomycosis Treatment" 2107:
Crawford F, Hollis S (July 2007). Crawford F (ed.).
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Canadian Agency for Drugs and Technologies in Health
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to humans, it generally infects skin and not nails.
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Based on appearance, confirmed by laboratory testing
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Andrews' Diseases of the Skin: clinical Dermatology
2024: 1688: 832:of the affected nail appears to improve outcomes. 6212:Disseminate and recurrent infundibulofolliculitis 2947:Diseases of the skin and appendages by morphology 2556: 2405: 1406:"What is nail psoriasis, and how can I treat it?" 1318: 1253:Onychomycosis: Diagnosis and Effective Management 878:, bringing the treatment cost to $ 715 per nail. 6552: 5199: 1091: 548:heavily, being in a humid or moist environment, 5316:Congenital onychodysplasia of the index fingers 2406:Halteh P, Scher RK, Lipner SR (November 2016). 2102: 2100: 2098: 599:There are five classic types of onychomycosis: 2106: 2059: 2027:Journal of the American Academy of Dermatology 1280:NHS Choices: Symptoms of fungal nail infection 1173: 6222:Erythromelanosis follicularis faciei et colli 5185: 4013: 3432:Pityriasis lichenoides et varioliformis acuta 2932: 2203: 1689:Roberts DT, Taylor WD, Boyle J (March 2003). 451:; though this fungus may be transmitted from 3086:Dermatofibroma (benign fibrous histiocytoma) 2354: 2095: 2053: 2018: 1355: 1312: 719:, laboratory confirmation may be necessary. 2747:Piraccini BM, Alessandrini A (March 2015). 2399: 2261:The Cochrane Database of Systematic Reviews 2155: 2113:The Cochrane Database of Systematic Reviews 1751: 1749: 1691:"Guidelines for treatment of onychomycosis" 1575: 1361: 1250:Rigopoulos D, Elewski B, Richert B (2018). 1207:The Cochrane Database of Systematic Reviews 1006:Rapini RP, Bolognia JL, Jorizzo JL (2007). 862:(PAS) was about $ 148. Even if the cheaper 5192: 5178: 4020: 4006: 2939: 2925: 2224: 1914: 1653: 1651: 1143: 1141: 1139: 1137: 1135: 1087: 1085: 1083: 1081: 1079: 1077: 1075: 1073: 1071: 1069: 1067: 1065: 1063: 1061: 1059: 1057: 1055: 1053: 1051: 1049: 1047: 1001: 999: 647:Endonyx onychomycosis is characterized by 479:, in particular members of the mold genus 247:, exposure to someone with the condition, 112:, exposure to someone with the condition, 4245:Trichophyton interdigitale/mentagrophytes 2774: 2764: 2560:Journal of Cutaneous Medicine and Surgery 2515: 2382: 2372: 2331: 2321: 2280: 2200:Loceryl (5% amorolfine) package labelling 2159:Journal of Cutaneous Medicine and Surgery 2132: 1932: 1891: 1773: 1509: 1499: 1226: 1133: 1131: 1129: 1127: 1125: 1123: 1121: 1119: 1117: 1115: 1045: 1043: 1041: 1039: 1037: 1035: 1033: 1031: 1029: 1027: 683: 300:A case of fungal infection of the big toe 30:Dermatophytic onychomycosis tinea unguium 6217:Erosive pustular dermatosis of the scalp 5637:Central centrifugal cicatricial alopecia 2483:Mayo clinic – Nail fungus: complications 1746: 1471:Mayo Clinic – Nail fungus – risk factors 1149:"Onychomycosis – Dermatologic Disorders" 920:and is 56% more frequent in people with 745: 308:Advanced fungal infection of the big toe 303: 295: 219:separation of the nail from the nail bed 4799:Allergic bronchopulmonary aspergillosis 4483:Progressive disseminated histoplasmosis 2303: 1865: 1648: 1569: 996: 6553: 6197:Acrokeratosis paraneoplastica of Bazex 3739:Disseminated intravascular coagulation 2060:Rodgers P, Bassler M (February 2001). 1434:"Onychomycosis: Rapid Evidence Review" 1112: 1024: 5173: 4001: 2920: 1603: 1599: 1597: 1275: 1273: 291: 6566:Mycosis-related cutaneous conditions 6237:Intermittent hair–follicle dystrophy 4714:Erosio interdigitalis blastomycetica 4454:Primary pulmonary coccidioidomycosis 4450:Primary cutaneous coccidioidomycosis 2442:"Ortho Dermatologics Access Program" 1796: 6174:Recurrent palmoplantar hidradenitis 6055:Idiopathic facial aseptic granuloma 5692:Marie Unna hereditary hypotrichosis 44:A toenail affected by onychomycosis 13: 5915:Lupus miliaris disseminatus faciei 5662:Dissecting cellulitis of the scalp 3564: 3521:Postinflammatory hyperpigmentation 2655:10.1046/j.1365-2133.1997.6771624.x 2643:The British Journal of Dermatology 2600:The British Journal of Dermatology 2355:Liddell LT, Rosen T (April 2015). 2310:Journal of Foot and Ankle Research 1984:The British Journal of Dermatology 1915:Elewski BE, Hay RJ (August 1996). 1698:The British Journal of Dermatology 1594: 1535:The British Journal of Dermatology 1270: 1153:Merck Manuals Professional Edition 1010:. St. Louis: Mosby. p. 1135. 443:is now restricted to the agent of 14: 6577: 6561:Conditions of the skin appendages 6179:Neutrophilic eccrine hidradenitis 5938:Granulomatous perioral dermatitis 3422:Transient acantholytic dermatosis 2563:. 10 Suppl 2 (6_suppl): S28–S33. 640:. It is the least common form of 594: 4699:Congenital cutaneous candidiasis 4478:Primary pulmonary histoplasmosis 4473:Primary cutaneous histoplasmosis 4180:Proximal subungual onychomycosis 3531:Idiopathic guttate hypomelanosis 2612:10.1046/j.1365-2133.1998.02464.x 2508:10.1046/j.0933-7407.2003.00933.x 1996:10.1046/j.1365-2133.2002.04825.x 1710:10.1046/j.1365-2133.2003.05242.x 1547:10.1111/j.1365-2133.2008.08805.x 1376:10.1111/j.1439-0507.2005.01152.x 1333:10.1111/j.1439-0507.2008.01618.x 853: 634:Proximal subungual onychomycosis 378: 349:of onychomycosis are all in the 35: 6339:Traumatic anserine folliculosis 6050:Granulomatous facial dermatitis 4804:Primary cutaneous aspergillosis 4445:Disseminated coccidioidomycosis 4170:White superficial onychomycosis 3541:Hypopigmented mycosis fungoides 2740: 2719: 2677: 2634: 2591: 2550: 2540: 2487: 2476: 2458: 2434: 2348: 2297: 2248: 2194: 2149: 1975: 1949: 1908: 1859: 1838: 1817: 1800:Sauer's Manual of Skin Diseases 1790: 1677:American Academy of Dermatology 1659:American Academy of Dermatology 1633:. Cmecorner.com. Archived from 1623: 1526: 1475: 1464: 1398: 910: 628:White superficial onychomycosis 532: 5361:Malalignment of the nail plate 4175:Distal subungual onychomycosis 3782:Lichen sclerosis et atrophicus 3490:Subcorneal pustular dermatosis 3116:Infantile digital fibromatosis 2273:10.1002/14651858.CD012093.pub2 2125:10.1002/14651858.CD001434.pub2 1775:10.1001/jamadermatol.2015.4190 1295: 1284: 1243: 1219:10.1002/14651858.CD010031.pub2 1194: 1167: 907:is another rare complication. 754: 604:Distal subungual onychomycosis 1: 5987:Erythrotelangiectatic rosacea 4519:Paracoccidioides brasiliensis 3374:Epidermolysis bullosa simplex 3211:Langerhans cell histiocytosis 1872:Clinical Microbiology Reviews 989: 511:mainly affects people in the 6242:Keratosis pilaris atropicans 6145:Folliculitis nares perforans 5067:Encephalitozoon intestinalis 4560:South American blastomycosis 4555:North American blastomycosis 4160:Tinea pedis (athlete's foot) 3850:Systemic lupus erythematosus 3605:Systemic lupus erythematosus 3296:Systemic lupus erythematosus 1921:Clinical Infectious Diseases 1576:James WD, Berger TG (2006). 956: 943: 927: 893: 741: 559: 7: 6012:Persistent edema of rosacea 5139:Granuloma gluteale infantum 4165:Tinea unguium/onychomycosis 3131:Lymphangioma circumscriptum 973: 606:is the most common form of 544:Other risk factors include 432:Trichophyton mentagrophytes 249:peripheral vascular disease 114:peripheral vascular disease 10: 6582: 6444:Postmiliarial hypohidrosis 6272:Menkes kinky hair syndrome 5687:Frontal fibrosing alopecia 5496:Staining of the nail plate 5356:Longitudinal erythronychia 5351:Lichen planus of the nails 4187:Tinea corporis gladiatorum 3953:Mucous membrane pemphigoid 2693: 2685: 2039:10.1016/j.jaad.2007.05.026 963: 950: 937: 860:periodic acid–Schiff stain 819: 589:periodic acid-Schiff stain 485:(name recently changed to 6526: 6498: 6399: 6388: 6329:Rubinstein–Taybi syndrome 6189: 6157:Pseudofolliculitis barbae 6130: 6077: 6042: 5923: 5779: 5768: 5700: 5528: 5519: 5456:Pterygium inversum unguis 5208: 5107: 5080: 5046: 4991: 4975:Syncephalastrum racemosum 4937: 4922: 4882: 4771: 4626: 4535: 4419: 4408: 4399: 4379: 4329: 4286: 4215: 4109: 4094: 4085: 4039: 3916: 3883: 3827: 3812: 3803: 3760: 3731: 3710: 3701: 3654: 3613: 3582: 3571: 3553: 3498: 3440: 3382: 3319: 3239: 3168: 3157: 3148: 3063: 3027: 2959: 2952: 2868: 2798: 2749:"Onychomycosis: A Review" 2066:American Family Physician 1501:10.1186/s12879-017-2258-3 1438:American Family Physician 1256:. John Wiley & Sons. 1176:American Family Physician 1094:American Family Physician 1008:Dermatology: 2-Volume Set 961:"fungus", and the suffix 881: 835:As of 2014, evidence for 759:Most treatments are with 691:To avoid misdiagnosis as 620:and the underside of the 610:and is usually caused by 578:polymerase chain reaction 566:potassium hydroxide smear 340: 192: 182: 166: 154: 133: 123: 99: 91: 83: 70: 60: 48: 43: 34: 26: 21: 6371:Uncombable hair syndrome 6355:Trichorrhexis invaginata 6169:Hidradenitis suppurativa 6027:Periorificial dermatitis 4982:Apophysomyces variabilis 4544:Blastomyces dermatitidis 4259:Trichophyton schoenleini 4224:Epidermophyton floccosum 3718:Thrombocytopenic purpura 3364:Dermatitis herpetiformis 3349:Acute contact dermatitis 3301:Pityriasis rubra pilaris 3226:Wiskott–Aldrich syndrome 3196:Lichen simplex chronicus 3076:Epidermal inclusion cyst 2062:"Treating onychomycosis" 1934:10.1093/clinids/23.2.305 1866:Elewski BE (July 1998). 1291:Mayo clinic: Nail fungus 886:In 2019, a study by the 462: 408:Tricholosporum violaceum 402:Epidermophyton floccosum 367:), and nondermatophytic 6349:Trichomycosis axillaris 6282:Parakeratosis pustulosa 5799:Acne miliaris necrotica 5580:(male-pattern baldness) 5544:noncicatricial alopecia 5466:Purpura of the nail bed 5063:Enterocytozoon bieneusi 5026:Conidiobolus incongruus 4968:Lichtheimia corymbifera 4893:Cryptococcus neoformans 4862:Pseudallescheria boydii 4351:Malassezia folliculitis 4273:Trichophyton verrucosum 3983:Squamous-cell carcinoma 3978:Systemic histoplasmosis 3369:Porphyria cutanea tarda 2999:Squamous-cell carcinoma 2709:A Greek–English Lexicon 2569:10.2310/7750.2006.00056 2172:10.2310/7750.2013.13095 1670:: an initiative of the 1488:BMC Infectious Diseases 848: 786:Topical agents include 239:. Risk factors include 6366:Trichostasis spinulosa 6060:Periorbital dermatitis 5977:Papulopustular rosacea 5895:Acne with facial edema 5885:Acne keloidalis nuchae 5672:Folliculitis decalvans 5667:Graham-Little syndrome 5421:Onychoptosis defluvium 5091:Rhinosporidium seeberi 5022:Conidiobolus coronatus 4761:Pneumocystis pneumonia 4750:Pneumocystis jirovecii 4679:Candidal onychomycosis 4669:Antibiotic candidiasis 4525:Paracoccidioidomycosis 4497:African histoplasmosis 4462:Histoplasma capsulatum 4434:Coccidioides posadasii 4252:Trichophyton tonsurans 3958:Cicatricial pemphigoid 3875:Acne keloidalis nuchae 3870:Folliculitis decalvans 2323:10.1186/1757-1146-7-34 2232:"Drugs at FDA: JUBLIA" 970:"functional disease". 751: 684:Differential diagnosis 663:Candidal onychomycosis 447:skin infection of the 309: 301: 160:anti-fungal medication 135:Differential diagnosis 6536:Sebaceous hyperplasia 6451:Granulosis rubra nasi 6314:Pityriasis amiantacea 6267:Loose anagen syndrome 6207:Bubble hair deformity 5997:Gram-negative rosacea 5760:Nevoid hypertrichosis 5632:Pseudopelade of Brocq 5511:Twenty-nail dystrophy 5386:Nail–patella syndrome 5366:Median nail dystrophy 4834:Phialophora verrucosa 4664:Chronic mucocutaneous 4582:Talaromyces marneffei 4238:Microsporum audouinii 3860:Loose anagen syndrome 3787:Necrobiosis lipoidica 3723:Actinic/solar purpura 3397:Insect bite reactions 3186:Seborrheic dermatitis 3009:Merkel-cell carcinoma 2989:Molluscum contagiosum 2700:Liddell, Henry George 2446:www.orthorxaccess.com 1580:. Saunders Elsevier. 905:Infection of the bone 774:(60% effective), and 749: 651:along with a lack of 475:and nondermatophytic 307: 299: 260:antifungal medication 6419:Miliaria crystalline 6360:Trichorrhexis nodosa 5627:cicatricial alopecia 5609:Alopecia neoplastica 5604:Trichorrhexis nodosa 5237:Yellow nail syndrome 5008:Basidiobolus ranarum 4998:Entomophthoramycosis 4812:Exophiala jeanselmei 4709:Systemic candidiasis 4704:Perianal candidiasis 4568:Sporothrix schenckii 4491:Histoplasma duboisii 4430:Coccidioides immitis 3683:Annulare centrifugum 3206:Glucagonoma syndrome 3004:Basal-cell carcinoma 2979:Seborrheic keratosis 2470:www.ncbi.nlm.nih.gov 2072:(4): 663–72, 677–8. 1884:10.1128/CMR.11.3.415 1182:(4): 663–72, 677–8. 984:photodynamic therapy 732:yellow nail syndrome 717:yellow nail syndrome 616:, which invades the 253:poor immune function 162:, trimming the nails 118:poor immune function 6518:Fox–Fordyce disease 6303:Pili pseudoannulati 6257:Lichen planopilaris 6232:Hair follicle nevus 6150:Tufted folliculitis 5933:Perioral dermatitis 5682:Triangular alopecia 5599:Lichen planopilaris 5578:Androgenic alopecia 5486:Splinter hemorrhage 5481:Shell nail syndrome 5326:Half and half nails 5120:Fungal folliculitis 4848:Geotrichum candidum 4840:Chromoblastomycosis 4684:Candidal paronychia 4674:Candidal intertrigo 4266:Trichophyton rubrum 3928:Aphthous stomatitis 3865:Lichen planopilaris 3840:Androgenic alopecia 3646:Fixed drug eruption 3221:Pemphigus foliaceus 3121:Granular cell tumor 2304:Bristow IR (2014). 728:green nail syndrome 613:Trichophyton rubrum 414:Microsporum gypseum 389:is the most common 386:Trichophyton rubrum 6439:Occlusion miliaria 6429:Miliaria pustulosa 6319:Plica neuropathica 6017:Rosacea conglobata 5828:Acne medicamentosa 5647:Traumatic alopecia 5501:Subungual hematoma 5032:Conidiobolomycosis 5014:Basidiobolomycosis 4830:Fonsecaea compacta 4826:Fonsecaea pedrosoi 4694:Diaper candidiasis 4440:Coccidioidomycosis 3948:Pemphigus vulgaris 3777:Granuloma annulare 3641:Carcinoid syndrome 3526:Tuberous sclerosis 3485:Coccidioidomycosis 3359:Bullous pemphigoid 3354:Pemphigus vulgaris 3286:Secondary syphilis 3176:Contact dermatitis 2869:External resources 2766:10.3390/jof1010030 2502:(11–12): 496–505. 2374:10.3390/jof1010044 752: 701:contact dermatitis 310: 302: 292:Signs and symptoms 55:Infectious disease 6548: 6547: 6544: 6543: 6424:Miliaria profunda 6384: 6383: 6376:Woolly hair nevus 6262:Lichen spinulosus 6100:Trichilemmal cyst 6073: 6072: 5992:Glandular rosacea 5945:Phymatous rosacea 5875:Occupational acne 5657:Hot comb alopecia 5642:Pressure alopecia 5619:Alopecia mucinosa 5594:Traction alopecia 5589:Telogen effluvium 5167: 5166: 5159:Phaeohyphomycosis 5144:Hyalohyphomycosis 5076: 5075: 5042: 5041: 4878: 4877: 4622: 4621: 4375: 4374: 4340:Malassezia furfur 4325: 4324: 4295:Hortaea werneckii 4282: 4281: 4231:Microsporum canis 3995: 3994: 3991: 3990: 3835:Telogen effluvium 3799: 3798: 3795: 3794: 3756: 3755: 3752: 3751: 3697: 3696: 3549: 3548: 3417:Lichen spinulosus 3412:Keratosis pilaris 3291:Mycosis fungoides 3191:Stasis dermatitis 3181:Atopic dermatitis 3144: 3143: 3019:Trichoepithelioma 2994:Actinic keratosis 2914: 2913: 1661:(February 2013), 1017:978-1-4160-2999-1 932:The term is from 576:examination, and 539:blood circulation 517:temperate climate 441:T. mentagrophytes 335:allergic reaction 200: 199: 125:Diagnostic method 16:Medical condition 6573: 6397: 6396: 6334:Setleis syndrome 6298:Pili multigemini 6032:Pyoderma faciale 5777: 5776: 5614:Anagen effluvium 5526: 5525: 5461:Pterygium unguis 5381:Muehrcke's lines 5268:Onychotillomania 5194: 5187: 5180: 5171: 5170: 5097:Rhinosporidiosis 5053:Microsporidiosis 4993:Entomophthorales 4935: 4934: 4912:Trichosporonosis 4638:Candida albicans 4612:Adiaspiromycosis 4417: 4416: 4406: 4405: 4397: 4396: 4346:Tinea versicolor 4107: 4106: 4092: 4091: 4083: 4082: 4029:Fungal infection 4022: 4015: 4008: 3999: 3998: 3933:Oral candidiasis 3810: 3809: 3708: 3707: 3636:Erythema nodosum 3580: 3579: 3569: 3568: 3562: 3561: 3506:Tinea versicolor 3344:Bullous impetigo 3281:Pityriasis rosea 3216:Lichen sclerosus 3201:Darier's disease 3166: 3165: 3155: 3154: 3111:Kaposi's sarcoma 2957: 2956: 2941: 2934: 2927: 2918: 2917: 2796: 2795: 2789: 2788: 2778: 2768: 2753:Journal of Fungi 2744: 2738: 2737: 2735: 2733: 2723: 2717: 2696: 2695: 2688: 2687: 2681: 2675: 2674: 2638: 2632: 2631: 2595: 2589: 2588: 2554: 2548: 2544: 2538: 2537: 2519: 2491: 2485: 2480: 2474: 2473: 2462: 2456: 2455: 2453: 2452: 2438: 2432: 2431: 2403: 2397: 2396: 2386: 2376: 2361:Journal of Fungi 2352: 2346: 2345: 2335: 2325: 2301: 2295: 2294: 2284: 2252: 2246: 2245: 2243: 2241: 2236: 2228: 2222: 2221: 2219: 2217: 2207: 2201: 2198: 2192: 2191: 2153: 2147: 2146: 2136: 2104: 2093: 2092: 2090: 2089: 2080:. Archived from 2057: 2051: 2050: 2022: 2016: 2015: 1979: 1973: 1972: 1970: 1968: 1953: 1947: 1946: 1936: 1912: 1906: 1905: 1895: 1863: 1857: 1856: 1854: 1852: 1842: 1836: 1835: 1833: 1831: 1821: 1815: 1814: 1794: 1788: 1787: 1777: 1762:JAMA Dermatology 1753: 1744: 1743: 1741: 1740: 1734: 1728:. Archived from 1695: 1687:. Which cites:* 1686: 1685: 1683: 1655: 1646: 1645: 1643: 1642: 1627: 1621: 1620: 1618: 1616: 1601: 1592: 1591: 1573: 1567: 1566: 1530: 1524: 1523: 1513: 1503: 1479: 1473: 1468: 1462: 1461: 1429: 1420: 1419: 1417: 1416: 1402: 1396: 1395: 1359: 1353: 1352: 1316: 1310: 1299: 1293: 1288: 1282: 1277: 1268: 1267: 1247: 1241: 1240: 1230: 1198: 1192: 1191: 1171: 1165: 1164: 1162: 1160: 1145: 1110: 1109: 1089: 1022: 1021: 1003: 966: 965: 959: 953: 952: 946: 940: 939: 806:azole antifungal 726:, normal aging, 525:Nail injury and 467:Other causative 437:T. interdigitale 396:T. interdigitale 321:are fungus-free 211:fungal infection 205:, also known as 95:Fungal infection 39: 19: 18: 6581: 6580: 6576: 6575: 6574: 6572: 6571: 6570: 6551: 6550: 6549: 6540: 6522: 6494: 6391: 6380: 6353:Trichorrhexis ( 6185: 6126: 6095:Epidermoid cyst 6069: 6038: 6002:Steroid rosacea 5919: 5880:Acne aestivalis 5818:Excoriated acne 5794:Acne conglobata 5771: 5764: 5696: 5533: 5515: 5491:Spotted lunulae 5451:Psoriatic nails 5406:Onychomatricoma 5219:Onychogryphosis 5204: 5202:skin appendages 5198: 5168: 5163: 5103: 5072: 5050: 5038: 4995: 4987: 4954:Rhizopus oryzae 4941: 4926: 4918: 4874: 4767: 4618: 4531: 4412: 4389: 4384: 4371: 4321: 4309:Piedraia hortae 4278: 4211: 4202:Tinea incognito 4197:Tinea imbricata 4101:Dermatophytosis 4098: 4072: 4063: 4054: 4048: 4044: 4035: 4026: 3996: 3987: 3919: 3912: 3879: 3845:Alopecia areata 3823: 3805: 3791: 3748: 3727: 3703: 3693: 3650: 3609: 3595:Viral exanthems 3573: 3557: 3555: 3545: 3516:Pityriasis alba 3494: 3436: 3378: 3315: 3235: 3231:Zinc deficiency 3161: 3159: 3140: 3068: 3059: 3023: 3014:Nevus sebaceous 2948: 2945: 2915: 2910: 2909: 2864: 2863: 2807: 2793: 2792: 2745: 2741: 2731: 2729: 2725: 2724: 2720: 2714:Perseus Project 2682: 2678: 2639: 2635: 2596: 2592: 2555: 2551: 2545: 2541: 2492: 2488: 2481: 2477: 2464: 2463: 2459: 2450: 2448: 2440: 2439: 2435: 2404: 2400: 2353: 2349: 2302: 2298: 2267:(1): CD012093. 2253: 2249: 2239: 2237: 2234: 2230: 2229: 2225: 2215: 2213: 2209: 2208: 2204: 2199: 2195: 2154: 2150: 2119:(3): CD001434. 2105: 2096: 2087: 2085: 2058: 2054: 2023: 2019: 1980: 1976: 1966: 1964: 1955: 1954: 1950: 1913: 1909: 1864: 1860: 1850: 1848: 1844: 1843: 1839: 1829: 1827: 1823: 1822: 1818: 1811: 1797:Hall B (2012). 1795: 1791: 1754: 1747: 1738: 1736: 1732: 1693: 1681: 1679: 1672:ABIM Foundation 1668:Choosing Wisely 1656: 1649: 1640: 1638: 1629: 1628: 1624: 1614: 1612: 1606:"Onychomycosis" 1602: 1595: 1588: 1574: 1570: 1531: 1527: 1480: 1476: 1469: 1465: 1430: 1423: 1414: 1412: 1404: 1403: 1399: 1360: 1356: 1317: 1313: 1300: 1296: 1289: 1285: 1278: 1271: 1264: 1248: 1244: 1213:(7): CD010031. 1199: 1195: 1172: 1168: 1158: 1156: 1155:. February 2017 1147: 1146: 1113: 1090: 1025: 1018: 1004: 997: 992: 976: 930: 913: 896: 884: 856: 851: 837:laser treatment 822: 757: 744: 686: 597: 562: 535: 465: 381: 343: 337:to the fungus. 294: 17: 12: 11: 5: 6579: 6569: 6568: 6563: 6546: 6545: 6542: 6541: 6539: 6538: 6532: 6530: 6524: 6523: 6521: 6520: 6515: 6510: 6504: 6502: 6496: 6495: 6493: 6492: 6491: 6490: 6480: 6479: 6478: 6473: 6468: 6458: 6456:Ross' syndrome 6453: 6448: 6447: 6446: 6441: 6436: 6434:Miliaria rubra 6431: 6426: 6421: 6416: 6414:Colloid milium 6405: 6403: 6394: 6386: 6385: 6382: 6381: 6379: 6378: 6373: 6368: 6363: 6357: 6351: 6346: 6341: 6336: 6331: 6326: 6321: 6316: 6311: 6305: 6300: 6295: 6293:Pili bifurcati 6290: 6284: 6279: 6274: 6269: 6264: 6259: 6254: 6252:Koenen's tumor 6249: 6244: 6239: 6234: 6229: 6224: 6219: 6214: 6209: 6204: 6202:Acroosteolysis 6199: 6193: 6191: 6187: 6186: 6184: 6183: 6182: 6181: 6176: 6171: 6160: 6159: 6154: 6153: 6152: 6147: 6136: 6134: 6128: 6127: 6125: 6124: 6119: 6118: 6117: 6112: 6106:Steatocystoma 6104: 6103: 6102: 6097: 6089:Sebaceous cyst 6084: 6082: 6075: 6074: 6071: 6070: 6068: 6067: 6065:SAPHO syndrome 6062: 6057: 6052: 6046: 6044: 6040: 6039: 6037: 6036: 6035: 6034: 6029: 6019: 6014: 6009: 6007:Ocular rosacea 6004: 5999: 5994: 5989: 5984: 5982:Lupoid rosacea 5979: 5974: 5973: 5972: 5967: 5962: 5957: 5952: 5942: 5941: 5940: 5929: 5927: 5921: 5920: 5918: 5917: 5912: 5907: 5905:Acne necrotica 5902: 5897: 5892: 5890:Acne mechanica 5887: 5882: 5877: 5872: 5870:Acne cosmetica 5867: 5862: 5857: 5856: 5855: 5850: 5845: 5835: 5825: 5823:Acne fulminans 5820: 5815: 5809:Infantile acne 5806: 5801: 5796: 5791: 5785: 5783: 5774: 5766: 5765: 5763: 5762: 5757: 5752: 5751: 5750: 5745: 5740: 5732: 5731: 5730: 5725: 5720: 5712: 5706: 5704: 5702:Hypertrichosis 5698: 5697: 5695: 5694: 5689: 5684: 5675: 5674: 5669: 5664: 5659: 5654: 5652:Tumor alopecia 5649: 5644: 5639: 5634: 5622: 5621: 5616: 5611: 5606: 5601: 5596: 5591: 5586: 5581: 5574: 5573: 5572: 5571: 5566: 5561: 5556: 5539: 5537: 5523: 5517: 5516: 5514: 5513: 5508: 5503: 5498: 5493: 5488: 5483: 5478: 5473: 5468: 5463: 5458: 5453: 5448: 5446:Plummer's nail 5443: 5438: 5433: 5428: 5423: 5418: 5413: 5408: 5403: 5398: 5393: 5388: 5383: 5378: 5373: 5368: 5363: 5358: 5353: 5348: 5343: 5338: 5333: 5328: 5323: 5318: 5313: 5308: 5307: 5306: 5301: 5289: 5288: 5283: 5276: 5275: 5270: 5263: 5262: 5257: 5250: 5249: 5244: 5239: 5234: 5227: 5226: 5221: 5214: 5212: 5206: 5205: 5197: 5196: 5189: 5182: 5174: 5165: 5164: 5162: 5161: 5156: 5151: 5146: 5141: 5136: 5135: 5134: 5122: 5117: 5111: 5109: 5105: 5104: 5102: 5101: 5100: 5099: 5086: 5084: 5082:Mesomycetozoea 5078: 5077: 5074: 5073: 5071: 5070: 5058: 5056: 5044: 5043: 5040: 5039: 5037: 5036: 5035: 5034: 5018: 5017: 5016: 5003: 5001: 4989: 4988: 4986: 4985: 4978: 4971: 4964: 4957: 4949: 4947: 4932: 4920: 4919: 4917: 4916: 4915: 4914: 4909: 4901: 4899:Cryptococcosis 4888: 4886: 4880: 4879: 4876: 4875: 4873: 4872: 4871: 4870: 4868:Allescheriasis 4858: 4857: 4856: 4844: 4843: 4842: 4822: 4821: 4820: 4808: 4807: 4806: 4801: 4796: 4791: 4778: 4776: 4769: 4768: 4766: 4765: 4764: 4763: 4758: 4756:Pneumocystosis 4746: 4739: 4732: 4725: 4718: 4717: 4716: 4711: 4706: 4701: 4696: 4691: 4686: 4681: 4676: 4671: 4666: 4661: 4656: 4651: 4646: 4633: 4631: 4624: 4623: 4620: 4619: 4617: 4616: 4615: 4614: 4606:Emmonsia parva 4602: 4597: 4595:Scedosporiosis 4592: 4591: 4590: 4578: 4577: 4576: 4574:Sporotrichosis 4564: 4563: 4562: 4557: 4552: 4539: 4537: 4533: 4532: 4530: 4529: 4528: 4527: 4515: 4514: 4513: 4501: 4500: 4499: 4487: 4486: 4485: 4480: 4475: 4470: 4468:Histoplasmosis 4458: 4457: 4456: 4447: 4442: 4425: 4423: 4414: 4403: 4394: 4377: 4376: 4373: 4372: 4370: 4369: 4368: 4367: 4355: 4354: 4353: 4348: 4335: 4333: 4327: 4326: 4323: 4322: 4320: 4319: 4318: 4317: 4305: 4304: 4303: 4290: 4288: 4284: 4283: 4280: 4279: 4277: 4276: 4269: 4262: 4255: 4248: 4241: 4234: 4227: 4219: 4217: 4213: 4212: 4210: 4209: 4204: 4199: 4194: 4189: 4184: 4183: 4182: 4177: 4172: 4162: 4157: 4152: 4147: 4146: 4145: 4143:Dermatophytids 4140: 4133:Tinea corporis 4130: 4129: 4128: 4113: 4111: 4104: 4089: 4080: 4051:dermatomycosis 4037: 4036: 4033:mesomycetozoea 4025: 4024: 4017: 4010: 4002: 3993: 3992: 3989: 3988: 3986: 3985: 3980: 3975: 3970: 3968:Coxsackievirus 3965: 3960: 3955: 3950: 3945: 3940: 3935: 3930: 3924: 3922: 3914: 3913: 3911: 3910: 3905: 3900: 3895: 3889: 3887: 3881: 3880: 3878: 3877: 3872: 3867: 3862: 3857: 3852: 3847: 3842: 3837: 3831: 3829: 3825: 3824: 3822: 3821: 3818: 3816: 3807: 3801: 3800: 3797: 3796: 3793: 3792: 3790: 3789: 3784: 3779: 3774: 3764: 3762: 3758: 3757: 3754: 3753: 3750: 3749: 3747: 3746: 3741: 3735: 3733: 3729: 3728: 3726: 3725: 3720: 3714: 3712: 3705: 3699: 3698: 3695: 3694: 3692: 3691: 3685: 3680: 3678:Gyratum repens 3675: 3670: 3664: 3658: 3656: 3652: 3651: 3649: 3648: 3643: 3638: 3633: 3628: 3623: 3617: 3615: 3611: 3610: 3608: 3607: 3602: 3600:Toxic erythema 3597: 3592: 3590:Drug eruptions 3586: 3584: 3577: 3566: 3559: 3551: 3550: 3547: 3546: 3544: 3543: 3538: 3533: 3528: 3523: 3518: 3513: 3508: 3502: 3500: 3496: 3495: 3493: 3492: 3487: 3482: 3477: 3472: 3467: 3462: 3457: 3452: 3446: 3444: 3438: 3437: 3435: 3434: 3429: 3427:Lichen nitidus 3424: 3419: 3414: 3409: 3404: 3399: 3394: 3388: 3386: 3380: 3379: 3377: 3376: 3371: 3366: 3361: 3356: 3351: 3346: 3341: 3336: 3331: 3329:Herpes simplex 3325: 3323: 3317: 3316: 3314: 3313: 3308: 3303: 3298: 3293: 3288: 3283: 3278: 3272: 3267: 3262: 3257: 3251: 3245: 3243: 3237: 3236: 3234: 3233: 3228: 3223: 3218: 3213: 3208: 3203: 3198: 3193: 3188: 3183: 3178: 3172: 3170: 3163: 3152: 3146: 3145: 3142: 3141: 3139: 3138: 3133: 3128: 3123: 3118: 3113: 3108: 3103: 3098: 3093: 3088: 3083: 3078: 3072: 3070: 3061: 3060: 3058: 3057: 3052: 3047: 3042: 3037: 3031: 3029: 3025: 3024: 3022: 3021: 3016: 3011: 3006: 3001: 2996: 2991: 2986: 2981: 2976: 2971: 2965: 2963: 2954: 2950: 2949: 2944: 2943: 2936: 2929: 2921: 2912: 2911: 2908: 2907: 2896: 2885: 2873: 2872: 2870: 2866: 2865: 2862: 2861: 2850: 2839: 2824: 2808: 2803: 2802: 2800: 2799:Classification 2791: 2790: 2739: 2718: 2676: 2633: 2590: 2549: 2539: 2486: 2475: 2472:. 8 June 2019. 2457: 2433: 2418:(5): E16–E25. 2398: 2347: 2296: 2247: 2223: 2202: 2193: 2148: 2094: 2052: 2017: 1974: 1948: 1907: 1858: 1837: 1816: 1809: 1789: 1745: 1647: 1622: 1593: 1586: 1568: 1525: 1474: 1463: 1444:(4): 359–367. 1421: 1397: 1354: 1311: 1294: 1283: 1269: 1262: 1242: 1193: 1166: 1111: 1100:(11): 762–70. 1023: 1016: 994: 993: 991: 988: 975: 972: 929: 926: 912: 909: 895: 892: 883: 880: 855: 852: 850: 847: 828:) or surgical 821: 818: 756: 753: 743: 740: 734:, and chronic 693:nail psoriasis 685: 682: 681: 680: 660: 657:hyperkeratosis 645: 631: 625: 596: 595:Classification 593: 561: 558: 554:athlete's foot 534: 531: 527:nail psoriasis 494:Scopulariopsis 488:Neoscytalidium 464: 461: 380: 377: 351:fungus kingdom 345:The causative 342: 339: 319:Dermatophytids 293: 290: 286:Georg Meissner 267:liver problems 241:athlete's foot 198: 197: 196:~10% of adults 194: 190: 189: 186: 180: 179: 170: 164: 163: 156: 152: 151: 137: 131: 130: 127: 121: 120: 106:Athlete's foot 103: 97: 96: 93: 89: 88: 85: 81: 80: 74: 68: 67: 64: 58: 57: 52: 46: 45: 41: 40: 32: 31: 28: 24: 23: 15: 9: 6: 4: 3: 2: 6578: 6567: 6564: 6562: 6559: 6558: 6556: 6537: 6534: 6533: 6531: 6529: 6525: 6519: 6516: 6514: 6513:Chromhidrosis 6511: 6509: 6506: 6505: 6503: 6501: 6497: 6489: 6486: 6485: 6484: 6481: 6477: 6474: 6472: 6469: 6467: 6464: 6463: 6462: 6461:Hyperhidrosis 6459: 6457: 6454: 6452: 6449: 6445: 6442: 6440: 6437: 6435: 6432: 6430: 6427: 6425: 6422: 6420: 6417: 6415: 6412: 6411: 6410: 6407: 6406: 6404: 6402: 6398: 6395: 6393: 6387: 6377: 6374: 6372: 6369: 6367: 6364: 6361: 6358: 6356: 6352: 6350: 6347: 6345: 6342: 6340: 6337: 6335: 6332: 6330: 6327: 6325: 6322: 6320: 6317: 6315: 6312: 6309: 6306: 6304: 6301: 6299: 6296: 6294: 6291: 6289: 6288:Pili annulati 6285: 6283: 6280: 6278: 6275: 6273: 6270: 6268: 6265: 6263: 6260: 6258: 6255: 6253: 6250: 6248: 6245: 6243: 6240: 6238: 6235: 6233: 6230: 6228: 6225: 6223: 6220: 6218: 6215: 6213: 6210: 6208: 6205: 6203: 6200: 6198: 6195: 6194: 6192: 6188: 6180: 6177: 6175: 6172: 6170: 6167: 6166: 6165: 6162: 6161: 6158: 6155: 6151: 6148: 6146: 6143: 6142: 6141: 6138: 6137: 6135: 6133: 6129: 6123: 6120: 6116: 6113: 6111: 6108: 6107: 6105: 6101: 6098: 6096: 6093: 6092: 6090: 6086: 6085: 6083: 6081: 6076: 6066: 6063: 6061: 6058: 6056: 6053: 6051: 6048: 6047: 6045: 6041: 6033: 6030: 6028: 6025: 6024: 6023: 6020: 6018: 6015: 6013: 6010: 6008: 6005: 6003: 6000: 5998: 5995: 5993: 5990: 5988: 5985: 5983: 5980: 5978: 5975: 5971: 5968: 5966: 5963: 5961: 5958: 5956: 5955:Blepharophyma 5953: 5951: 5948: 5947: 5946: 5943: 5939: 5936: 5935: 5934: 5931: 5930: 5928: 5926: 5922: 5916: 5913: 5911: 5908: 5906: 5903: 5901: 5898: 5896: 5893: 5891: 5888: 5886: 5883: 5881: 5878: 5876: 5873: 5871: 5868: 5866: 5863: 5861: 5858: 5854: 5851: 5849: 5846: 5844: 5841: 5840: 5839: 5836: 5833: 5829: 5826: 5824: 5821: 5819: 5816: 5814: 5813:Neonatal acne 5810: 5807: 5805: 5804:Tropical acne 5802: 5800: 5797: 5795: 5792: 5790: 5789:Acne vulgaris 5787: 5786: 5784: 5782: 5778: 5775: 5773: 5767: 5761: 5758: 5756: 5753: 5749: 5746: 5744: 5741: 5739: 5736: 5735: 5733: 5729: 5726: 5724: 5721: 5719: 5716: 5715: 5713: 5711: 5708: 5707: 5705: 5703: 5699: 5693: 5690: 5688: 5685: 5683: 5680: 5677: 5676: 5673: 5670: 5668: 5665: 5663: 5660: 5658: 5655: 5653: 5650: 5648: 5645: 5643: 5640: 5638: 5635: 5633: 5630: 5628: 5624: 5623: 5620: 5617: 5615: 5612: 5610: 5607: 5605: 5602: 5600: 5597: 5595: 5592: 5590: 5587: 5585: 5584:Hypotrichosis 5582: 5579: 5576: 5575: 5570: 5567: 5565: 5562: 5560: 5557: 5555: 5552: 5551: 5550: 5547: 5545: 5541: 5540: 5538: 5536: 5531: 5527: 5524: 5522: 5518: 5512: 5509: 5507: 5506:Terry's nails 5504: 5502: 5499: 5497: 5494: 5492: 5489: 5487: 5484: 5482: 5479: 5477: 5474: 5472: 5469: 5467: 5464: 5462: 5459: 5457: 5454: 5452: 5449: 5447: 5444: 5442: 5439: 5437: 5434: 5432: 5431:Onychoschizia 5429: 5427: 5426:Onychorrhexis 5424: 5422: 5419: 5417: 5414: 5412: 5411:Onychomycosis 5409: 5407: 5404: 5402: 5401:Onychomadesis 5399: 5397: 5394: 5392: 5391:Onychoatrophy 5389: 5387: 5384: 5382: 5379: 5377: 5374: 5372: 5369: 5367: 5364: 5362: 5359: 5357: 5354: 5352: 5349: 5347: 5344: 5342: 5339: 5337: 5334: 5332: 5329: 5327: 5324: 5322: 5319: 5317: 5314: 5312: 5309: 5305: 5302: 5300: 5297: 5296: 5295: 5291: 5290: 5287: 5284: 5282: 5278: 5277: 5274: 5271: 5269: 5265: 5264: 5261: 5260:Nail clubbing 5258: 5256: 5252: 5251: 5248: 5245: 5243: 5240: 5238: 5235: 5233: 5229: 5228: 5225: 5222: 5220: 5216: 5215: 5213: 5211: 5207: 5203: 5200:Disorders of 5195: 5190: 5188: 5183: 5181: 5176: 5175: 5172: 5160: 5157: 5155: 5154:Keratomycosis 5152: 5150: 5147: 5145: 5142: 5140: 5137: 5133: 5130: 5129: 5128: 5127: 5123: 5121: 5118: 5116: 5115:Alternariosis 5113: 5112: 5110: 5106: 5098: 5095: 5094: 5093: 5092: 5088: 5087: 5085: 5083: 5079: 5069: 5068: 5064: 5060: 5059: 5057: 5054: 5049: 5048:Microsporidia 5045: 5033: 5030: 5029: 5028: 5027: 5023: 5019: 5015: 5012: 5011: 5010: 5009: 5005: 5004: 5002: 4999: 4994: 4990: 4984: 4983: 4979: 4977: 4976: 4972: 4970: 4969: 4965: 4963: 4962: 4961:Mucor indicus 4958: 4956: 4955: 4951: 4950: 4948: 4945: 4940: 4936: 4933: 4930: 4925: 4921: 4913: 4910: 4907: 4906: 4902: 4900: 4897: 4896: 4895: 4894: 4890: 4889: 4887: 4885: 4884:Basidiomycota 4881: 4869: 4866: 4865: 4864: 4863: 4859: 4855: 4852: 4851: 4850: 4849: 4845: 4841: 4838: 4837: 4836: 4835: 4831: 4827: 4823: 4819: 4816: 4815: 4814: 4813: 4809: 4805: 4802: 4800: 4797: 4795: 4792: 4790: 4789:Aspergillosis 4787: 4786: 4785: 4784: 4780: 4779: 4777: 4774: 4770: 4762: 4759: 4757: 4754: 4753: 4752: 4751: 4747: 4745: 4744: 4743:C. tropicalis 4740: 4738: 4737: 4736:C. lusitaniae 4733: 4731: 4730: 4726: 4724: 4723: 4719: 4715: 4712: 4710: 4707: 4705: 4702: 4700: 4697: 4695: 4692: 4690: 4687: 4685: 4682: 4680: 4677: 4675: 4672: 4670: 4667: 4665: 4662: 4660: 4657: 4655: 4652: 4650: 4647: 4645: 4642: 4641: 4640: 4639: 4635: 4634: 4632: 4629: 4625: 4613: 4610: 4609: 4608: 4607: 4603: 4601: 4598: 4596: 4593: 4589: 4588:Talaromycosis 4586: 4585: 4584: 4583: 4579: 4575: 4572: 4571: 4570: 4569: 4565: 4561: 4558: 4556: 4553: 4551: 4550:Blastomycosis 4548: 4547: 4546: 4545: 4541: 4540: 4538: 4534: 4526: 4523: 4522: 4521: 4520: 4516: 4512: 4509: 4508: 4507: 4506: 4505:Lacazia loboi 4502: 4498: 4495: 4494: 4493: 4492: 4488: 4484: 4481: 4479: 4476: 4474: 4471: 4469: 4466: 4465: 4464: 4463: 4459: 4455: 4451: 4448: 4446: 4443: 4441: 4438: 4437: 4436: 4435: 4431: 4427: 4426: 4424: 4422: 4418: 4415: 4411: 4407: 4404: 4402: 4398: 4395: 4393: 4392:opportunistic 4387: 4382: 4378: 4366: 4363: 4362: 4361: 4360: 4356: 4352: 4349: 4347: 4344: 4343: 4342: 4341: 4337: 4336: 4334: 4332: 4331:Basidiomycota 4328: 4316: 4313: 4312: 4311: 4310: 4306: 4302: 4299: 4298: 4297: 4296: 4292: 4291: 4289: 4285: 4275: 4274: 4270: 4268: 4267: 4263: 4261: 4260: 4256: 4254: 4253: 4249: 4247: 4246: 4242: 4240: 4239: 4235: 4233: 4232: 4228: 4226: 4225: 4221: 4220: 4218: 4214: 4208: 4205: 4203: 4200: 4198: 4195: 4193: 4190: 4188: 4185: 4181: 4178: 4176: 4173: 4171: 4168: 4167: 4166: 4163: 4161: 4158: 4156: 4153: 4151: 4148: 4144: 4141: 4139: 4136: 4135: 4134: 4131: 4127: 4124: 4123: 4122: 4121:tinea capitis 4118: 4115: 4114: 4112: 4108: 4105: 4102: 4097: 4093: 4090: 4088: 4084: 4081: 4079: 4075: 4070: 4066: 4061: 4057: 4052: 4047: 4042: 4038: 4034: 4030: 4023: 4018: 4016: 4011: 4009: 4004: 4003: 4000: 3984: 3981: 3979: 3976: 3974: 3971: 3969: 3966: 3964: 3961: 3959: 3956: 3954: 3951: 3949: 3946: 3944: 3941: 3939: 3938:Lichen planus 3936: 3934: 3931: 3929: 3926: 3925: 3923: 3921: 3915: 3909: 3906: 3904: 3901: 3899: 3896: 3894: 3893:Onychomycosis 3891: 3890: 3888: 3886: 3882: 3876: 3873: 3871: 3868: 3866: 3863: 3861: 3858: 3856: 3855:Tinea capitis 3853: 3851: 3848: 3846: 3843: 3841: 3838: 3836: 3833: 3832: 3830: 3826: 3820: 3819: 3817: 3815: 3811: 3808: 3804:Miscellaneous 3802: 3788: 3785: 3783: 3780: 3778: 3775: 3773: 3769: 3766: 3765: 3763: 3759: 3745: 3742: 3740: 3737: 3736: 3734: 3730: 3724: 3721: 3719: 3716: 3715: 3713: 3709: 3706: 3702:Nonblanchable 3700: 3689: 3686: 3684: 3681: 3679: 3676: 3674: 3671: 3669: 3665: 3663: 3660: 3659: 3657: 3653: 3647: 3644: 3642: 3639: 3637: 3634: 3632: 3629: 3627: 3624: 3622: 3619: 3618: 3616: 3612: 3606: 3603: 3601: 3598: 3596: 3593: 3591: 3588: 3587: 3585: 3581: 3578: 3576: 3570: 3567: 3563: 3560: 3552: 3542: 3539: 3537: 3534: 3532: 3529: 3527: 3524: 3522: 3519: 3517: 3514: 3512: 3509: 3507: 3504: 3503: 3501: 3499:Hypopigmented 3497: 3491: 3488: 3486: 3483: 3481: 3478: 3476: 3473: 3471: 3468: 3466: 3463: 3461: 3458: 3456: 3453: 3451: 3450:Acne vulgaris 3448: 3447: 3445: 3443: 3439: 3433: 3430: 3428: 3425: 3423: 3420: 3418: 3415: 3413: 3410: 3408: 3405: 3403: 3402:Lichen planus 3400: 3398: 3395: 3393: 3390: 3389: 3387: 3385: 3381: 3375: 3372: 3370: 3367: 3365: 3362: 3360: 3357: 3355: 3352: 3350: 3347: 3345: 3342: 3340: 3337: 3335: 3334:Herpes zoster 3332: 3330: 3327: 3326: 3324: 3322: 3318: 3312: 3309: 3307: 3306:Parapsoriasis 3304: 3302: 3299: 3297: 3294: 3292: 3289: 3287: 3284: 3282: 3279: 3276: 3273: 3271: 3268: 3266: 3263: 3261: 3258: 3256: 3252: 3250: 3247: 3246: 3244: 3242: 3238: 3232: 3229: 3227: 3224: 3222: 3219: 3217: 3214: 3212: 3209: 3207: 3204: 3202: 3199: 3197: 3194: 3192: 3189: 3187: 3184: 3182: 3179: 3177: 3174: 3173: 3171: 3167: 3164: 3156: 3153: 3151: 3147: 3137: 3134: 3132: 3129: 3127: 3124: 3122: 3119: 3117: 3114: 3112: 3109: 3107: 3104: 3102: 3099: 3097: 3094: 3092: 3089: 3087: 3084: 3082: 3079: 3077: 3074: 3073: 3071: 3066: 3062: 3056: 3053: 3051: 3048: 3046: 3043: 3041: 3038: 3036: 3033: 3032: 3030: 3026: 3020: 3017: 3015: 3012: 3010: 3007: 3005: 3002: 3000: 2997: 2995: 2992: 2990: 2987: 2985: 2982: 2980: 2977: 2975: 2972: 2970: 2967: 2966: 2964: 2962: 2958: 2955: 2951: 2942: 2937: 2935: 2930: 2928: 2923: 2922: 2919: 2906: 2905:Onychomycosis 2902: 2901: 2897: 2895: 2891: 2890: 2886: 2884: 2880: 2879: 2875: 2874: 2871: 2867: 2860: 2856: 2855: 2851: 2849: 2845: 2844: 2840: 2838: 2834: 2833: 2829: 2825: 2823: 2819: 2818: 2814: 2810: 2809: 2806: 2801: 2797: 2786: 2782: 2777: 2772: 2767: 2762: 2758: 2754: 2750: 2743: 2728: 2722: 2715: 2711: 2710: 2705: 2704:Scott, Robert 2701: 2697: 2689: 2680: 2672: 2668: 2664: 2660: 2656: 2652: 2648: 2644: 2637: 2629: 2625: 2621: 2617: 2613: 2609: 2606:(4): 665–71. 2605: 2601: 2594: 2586: 2582: 2578: 2574: 2570: 2566: 2562: 2561: 2553: 2543: 2535: 2531: 2527: 2523: 2518: 2513: 2509: 2505: 2501: 2497: 2490: 2484: 2479: 2471: 2467: 2461: 2447: 2443: 2437: 2430: 2425: 2421: 2417: 2413: 2409: 2402: 2394: 2390: 2385: 2380: 2375: 2370: 2366: 2362: 2358: 2351: 2343: 2339: 2334: 2329: 2324: 2319: 2315: 2311: 2307: 2300: 2292: 2288: 2283: 2278: 2274: 2270: 2266: 2262: 2258: 2251: 2233: 2227: 2212: 2206: 2197: 2189: 2185: 2181: 2177: 2173: 2169: 2165: 2161: 2160: 2152: 2144: 2140: 2135: 2130: 2126: 2122: 2118: 2114: 2110: 2103: 2101: 2099: 2084:on 2008-05-14 2083: 2079: 2075: 2071: 2067: 2063: 2056: 2048: 2044: 2040: 2036: 2033:(5): 879–82. 2032: 2028: 2021: 2013: 2009: 2005: 2001: 1997: 1993: 1990:(1): 118–21. 1989: 1985: 1978: 1963:. 19 May 2016 1962: 1958: 1952: 1944: 1940: 1935: 1930: 1927:(2): 305–13. 1926: 1922: 1918: 1911: 1903: 1899: 1894: 1889: 1885: 1881: 1878:(3): 415–29. 1877: 1873: 1869: 1862: 1847: 1841: 1826: 1820: 1812: 1810:9781451148688 1806: 1802: 1801: 1793: 1785: 1781: 1776: 1771: 1768:(3): 276–81. 1767: 1763: 1759: 1752: 1750: 1735:on 2017-08-10 1731: 1727: 1723: 1719: 1715: 1711: 1707: 1704:(3): 402–10. 1703: 1699: 1692: 1678: 1674: 1673: 1669: 1664: 1660: 1654: 1652: 1637:on 2011-07-08 1636: 1632: 1626: 1611: 1607: 1600: 1598: 1589: 1587:0-7216-2921-0 1583: 1579: 1572: 1564: 1560: 1556: 1552: 1548: 1544: 1540: 1536: 1529: 1521: 1517: 1512: 1507: 1502: 1497: 1493: 1489: 1485: 1478: 1472: 1467: 1459: 1455: 1451: 1447: 1443: 1439: 1435: 1428: 1426: 1411: 1407: 1401: 1393: 1389: 1385: 1381: 1377: 1373: 1370:(6): 413–20. 1369: 1365: 1358: 1350: 1346: 1342: 1338: 1334: 1330: 1326: 1322: 1315: 1309: 1305: 1304: 1303:Onychomycosis 1298: 1292: 1287: 1281: 1276: 1274: 1265: 1263:9781119226505 1259: 1255: 1254: 1246: 1238: 1234: 1229: 1224: 1220: 1216: 1212: 1208: 1204: 1197: 1189: 1185: 1181: 1177: 1170: 1154: 1150: 1144: 1142: 1140: 1138: 1136: 1134: 1132: 1130: 1128: 1126: 1124: 1122: 1120: 1118: 1116: 1107: 1103: 1099: 1095: 1088: 1086: 1084: 1082: 1080: 1078: 1076: 1074: 1072: 1070: 1068: 1066: 1064: 1062: 1060: 1058: 1056: 1054: 1052: 1050: 1048: 1046: 1044: 1042: 1040: 1038: 1036: 1034: 1032: 1030: 1028: 1019: 1013: 1009: 1002: 1000: 995: 987: 985: 981: 971: 969: 960: 958: 947: 945: 935: 934:Ancient Greek 925: 923: 919: 916:one-third of 908: 906: 902: 891: 889: 879: 877: 872: 870: 869:efinaconazole 865: 861: 854:United States 846: 844: 840: 838: 833: 831: 827: 817: 815: 809: 807: 803: 802:Efinaconazole 799: 797: 796:efinaconazole 793: 789: 784: 781: 777: 773: 768: 766: 762: 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4243: 4236: 4229: 4222: 4192:Tinea faciei 4164: 4155:Tinea manuum 4150:Tinea cruris 4117:Tinea barbae 4096:Dermatophyte 3908:Ingrown nail 3892: 3480:Dermatophyte 3475:Gonococcemia 3460:Folliculitis 3101:Neurofibroma 3069:subcutaneous 2898: 2887: 2876: 2852: 2841: 2826: 2811: 2759:(1): 30–43. 2756: 2752: 2742: 2730:. 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Retrieved 1152: 1097: 1093: 1007: 977: 967: 954: 941: 931: 914: 911:Epidemiology 897: 885: 876:drug coupons 873: 857: 843:Tea tree oil 841: 834: 823: 810: 804:, a topical 800: 790:nail paint, 785: 780:Ketoconazole 772:itraconazole 769: 758: 721: 690: 687: 666: 641: 611: 607: 598: 582: 563: 543: 536: 533:Risk factors 524: 521: 508: 504: 498: 492: 486: 480: 472: 466: 440: 436: 430: 424: 420:T. tonsurans 418: 412: 406: 400: 394: 391:dermatophyte 384: 382: 372: 358: 353:and include 344: 323:skin lesions 315:psychosocial 311: 282: 276:-containing 271: 257: 234: 206: 202: 201: 188:Often recurs 101:Risk factors 6466:Generalized 6277:Monilethrix 6078:Follicular 5960:Gnathophyma 5900:Pomade acne 5755:Prepubertal 5738:generalised 5734:Congenital 5723:generalised 5564:universalis 5476:Red lunulae 5436:Platonychia 5396:Onycholysis 5371:Mees' lines 5321:Green nails 5292:ungrouped: 5255:Koilonychia 5242:Leukonychia 5217:thickness: 4929:Zygomycosis 4783:Aspergillus 4729:C. glabrata 4644:Candidiasis 4600:Emmonsiosis 4511:Lobomycosis 4301:Tinea nigra 4216:By organism 4110:By location 4041:Superficial 3963:Herpesvirus 3943:Leukoplakia 3768:Scleroderma 3655:Specialized 3583:Generalized 3558:involvement 3470:Candidiasis 3162:involvement 3136:Myxoid cyst 2984:Acrochordon 2878:MedlinePlus 2732:23 December 1541:(1): 37–9. 1410:www.aad.org 830:debridement 826:keratolytic 776:fluconazole 765:terbinafine 755:Medications 703:, nail bed 653:onycholysis 649:leukonychia 583:Nail plate 509:Scytalidium 500:Aspergillus 482:Scytalidium 439:. The name 278:nail polish 272:There is a 263:terbinafine 223:Fingernails 173:Terbinafine 87:Older males 84:Usual onset 27:Other names 6555:Categories 6488:Anhidrosis 6308:Pili torti 6227:Hair casts 5950:Rhinophyma 5848:Bromoderma 5679:ungrouped: 5294:Paronychia 5266:behavior: 5224:Onychauxis 5149:Otomycosis 5132:Fusariosis 4924:Zygomycota 4818:Eumycetoma 4654:Esophageal 4421:Onygenales 4401:Ascomycota 4087:Ascomycota 3903:Paronychia 3744:Vasculitis 3668:Multiforme 3666:Erythema ( 3621:Cellulitis 3572:Blanchable 3321:Blistering 3311:Ichthyosis 3169:Eczematous 3081:Hemangioma 2900:Patient UK 2854:DiseasesDB 2451:2021-08-10 2088:2007-09-18 1739:2014-08-01 1682:5 December 1641:2010-08-05 1494:(1): 166. 1415:2022-06-18 990:References 901:cellulitis 824:Chemical ( 814:tavaborole 792:amorolfine 788:ciclopirox 761:antifungal 736:paronychia 622:nail plate 546:perspiring 455:and their 274:ciclopirox 227:cellulitis 177:ciclopirox 168:Medication 148:paronychia 146:, chronic 144:dermatitis 142:, chronic 78:cellulitis 76:Lower leg 6528:Sebaceous 6508:Body odor 6471:Gustatory 6190:Ungrouped 6115:multiplex 6043:Ungrouped 5965:Metophyma 5910:Blackhead 5853:Chloracne 5843:Iododerma 5770:Acneiform 5743:localised 5728:patterned 5718:localised 5714:Acquired 5710:Hirsutism 5530:Hair loss 5341:Hook nail 5286:Anonychia 5108:Ungrouped 4939:Mucorales 4410:Dimorphic 4074:endothrix 4046:cutaneous 3898:Psoriasis 3806:disorders 3761:Indurated 3662:Urticaria 3614:Localized 3556:epidermal 3339:Varicella 3249:Psoriasis 3160:epidermal 3126:Leiomyoma 3028:Pigmented 2961:Epidermal 2889:eMedicine 1825:"MOB-015" 1450:1532-0650 1308:eMedicine 928:Etymology 922:psoriasis 918:diabetics 894:Prognosis 742:Treatment 724:psoriasis 673:infection 638:nail fold 574:histology 560:Diagnosis 550:psoriasis 469:pathogens 347:pathogens 193:Frequency 184:Prognosis 155:Treatment 140:Psoriasis 50:Specialty 6500:Apocrine 6409:Miliaria 6324:Poliosis 6022:variants 5970:Otophyma 5865:Tar acne 5860:Oil acne 5772:eruption 5748:X-linked 5569:Ophiasis 5549:Alopecia 5535:Baldness 5331:Hangnail 5126:Fusarium 4722:C. auris 4689:Candidid 4386:systemic 4138:Ringworm 4069:exothrix 3973:Syphilis 3920:membrane 3575:Erythema 3511:Vitiligo 3465:Impetigo 3442:Pustular 3407:Miliaria 3255:Corporis 3106:Xanthoma 3055:Melanoma 3035:Freckles 2894:derm/300 2785:29376897 2628:22038748 2585:74819774 2577:17204229 2534:20055970 2526:14641624 2517:1942/429 2424:28040821 2393:29376898 2342:25104974 2291:31978269 2188:10079807 2180:24800702 2143:17636672 2078:11237081 2047:17610995 2012:19682557 2004:12100193 1784:26716567 1726:33750748 1718:12653730 1610:Medscape 1563:42320540 1555:18764841 1520:28222676 1458:34652111 1392:43885361 1384:16262878 1349:26932678 1341:18793262 1237:28707751 1188:11237081 1106:24364524 974:Research 948:"nail", 864:KOH test 709:melanoma 707:such as 618:nail bed 471:include 243:, other 236:Fusarium 108:, other 62:Symptoms 6401:Eccrine 6110:simplex 5925:Rosacea 5830:(e.g., 5559:totalis 5304:Chronic 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Index


Specialty
Infectious disease
Symptoms
Complications
cellulitis
Risk factors
Athlete's foot
nail diseases
peripheral vascular disease
poor immune function
Diagnostic method
Differential diagnosis
Psoriasis
dermatitis
paronychia
anti-fungal medication
Medication
Terbinafine
ciclopirox
Prognosis
fungal infection
nail
separation of the nail from the nail bed
Fingernails
cellulitis
dermatophytes
Fusarium
athlete's foot
nail diseases

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