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Obsessive–compulsive disorder

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behavioral observations and reports, is a key component to the success of such treatments. Parental interventions also provide positive reinforcement for a child who exhibits appropriate behaviors as alternatives to compulsive responses. In a recent meta-analysis of evidenced-based treatment of OCD in children, family-focused individual CBT was labeled as "probably efficacious," establishing it as one of the leading psychosocial treatments for youth with OCD. After one or two years of therapy, in which a child learns the nature of their obsession and acquires strategies for coping, they may acquire a larger circle of friends, exhibit less shyness, and become less self-critical. Trials have shown that children and adolescents with OCD should begin treatment with the combination of CBT with a selective serotonin reuptake inhibitor or CBT alone, rather than only an SSRI.
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depression, anxiety, and disruptive behavior disorder. Continually, children are more likely to struggle in school and experience difficulties in social situations (Lack 2012). When looking at both adults and children a study found the average ages of onset to be 21 and 24 for males and females respectively. While some studies have shown that OCD with earlier onset is associated with greater severity, other studies have not been able to validate this finding. Looking at women specifically, a different study suggested that 62% of participants found that their symptoms worsened at a premenstrual age. Across the board, all demographics and studies showed a mean age of onset of less than 25.
2139: 1894:. According to inference-based therapy, obsessional thinking occurs when the person replaces reality and real probabilities with imagined possibilities. The goal of inference-based therapy is to reorient clients towards trusting the senses and relating to reality in a normal, non-effortful way. Differences between normal and obsessional doubts are presented, and clients are encouraged to use their senses and reasoning as they do in non-obsessive-compulsive disorder situations. Research on Inference-Based Cognitive-Behavior Therapy (I-CBT) suggests it can lead to improvements for those with OCD. 1361: 941:
slowness, and doubting, are not included in a rating of overall severity. The CY-BOCS has demonstrated good convergent validity with clinician-rated OCD severity, and good to fair discriminant validity from measures of closely related anxiety, depression, and tic severity. The CY-BOCS Total Severity score is an important monitoring tool as it is responsive to pharmacotherapy and psychotherapy. Positive treatment response is characterized by 25% reduction in CY-BOCS total score, and diagnostic remission is associated with a 45%-50% reduction in Total Severity score (or a score <15).
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necessarily perform these actions compulsively; for example, morning or nighttime routines and religious practices are not usually compulsions. Whether behaviors qualify as compulsions or mere habit depends on the context in which they are performed. For instance, arranging and ordering books for eight hours a day would be expected of someone who works in a library, but this routine would seem abnormal in other situations. In other words, habits tend to bring efficiency to one's life, while compulsions tend to disrupt it. Furthermore, compulsions are different from
819:(DSM-5), identifies a continuum for the level of insight in OCD, ranging from good insight (the least severe) to no insight (the most severe). Good or fair insight is characterized by the acknowledgment that obsessive–compulsive beliefs are not or may not be true, while poor insight, in the middle of the continuum, is characterized by the belief that obsessive–compulsive beliefs are probably true. The absence of insight altogether, in which the individual is completely convinced that their beliefs are true, is also identified as a 757:
directly related to the obsession, such as someone obsessed with contamination compulsively washing their hands, but they can be unrelated as well. In addition to experiencing the anxiety and fear that typically accompanies OCD, affected individuals may spend hours performing compulsions every day. In such situations, it can become difficult for the person to fulfill their work, familial, or social roles. These behaviors can also cause adverse physical symptoms; for example, people who obsessively wash their hands with
1318:(pediatric acute-onset neuropsychiatric syndrome) and CANS (childhood acute neuropsychiatric syndrome). The CANS and PANS hypotheses include different possible mechanisms underlying acute-onset neuropsychiatric conditions, but do not exclude GABHS infections as a cause in a subset of individuals. PANDAS, PANS, and CANS are the focus of clinical and laboratory research, but remain unproven. Whether PANDAS is a distinct entity differing from other cases of tic disorders or OCD is debated. 571: 1721:
actions often associated with OCD (such as ordering items in a pantry by height), the distinction with clinically significant OCD lies in the fact that the person with OCD must perform these actions to avoid significant psychological distress. These behaviors or mental acts are aimed at preventing or reducing distress or preventing some dreaded event or situation; however, these activities are not logically or practically connected to the issue, or, they are excessive.
485:, approximately 1 in 40 U.S. adults and 1 in 100 U.S. children have OCD. Although possible at times with triggers such as pregnancy, onset rarely occurs after age 35, and about 50% of patients experience detrimental effects to daily life before age 20. While OCD occurs worldwide, a recent meta-analysis showed that women are 1.6 times more likely to experience OCD. Based on data from 34 studies, the worldwide prevalence rate is 1.5% in women and 1% in men. 590:, to seek relief from obsession-related anxiety. Within and among individuals, initial obsessions vary in clarity and vividness. A relatively vague obsession could involve a general sense of disarray or tension, accompanied by a belief that life cannot proceed as normal while the imbalance remains. A more intense obsession could be a preoccupation with the thought or image of a close family member or friend dying, or intrusive thoughts related to 1833:(ERP), which involves teaching the person to deliberately come into contact with situations that trigger obsessive thoughts and fears (exposure), without carrying out the usual compulsive acts associated with the obsession (response prevention). This technique causes patients to gradually learn to tolerate the discomfort and anxiety associated with not performing their compulsions. For many patients, ERP is the add-on treatment of choice when 2837:(IOCDF) is the largest 501(c)3 nonprofit organization dedicated to serving a broad community of individuals with OCD and related disorders, their family members and loved ones, and mental health professionals and researchers around the world. Since 1986, the IOCDF provides up-to-date education and resources, strengthens community engagement worldwide, delivers quality professional training to clinicians, and funds groundbreaking research. 2773: 2460:, stating, "These things may seem ridiculous to others, even as ridiculous as they were in themselves, but to me they were the most tormenting cogitations." He wrote two pamphlets advising those with similar anxieties. In one of them, he warns against indulging in compulsions: "Have care of putting off your trouble of spirit in the wrong way: by promising to reform yourself and lead a new life, by your performances or duties". 1756:
Poor indicates that the patient believes their obsessional beliefs are probably true. Absent/delusional indicates that they fully believe their obsessional thoughts to be true. Approximately 4% or fewer individuals with OCD will be diagnosed as absent/delusional. Additionally, as many as 30% of those with OCD also have a lifetime tic disorder, meaning they have been diagnosed with a tic disorder at some point in their life.
780:(CBT), OCD patients are asked to overcome intrusive thoughts by not indulging in any compulsions. They are taught that rituals keep OCD strong, while not performing them causes OCD to become weaker. This position is supported by the pattern of memory distrust; the more often compulsions are repeated, the more weakened memory trust becomes, and this cycle continues as memory distrust increases compulsion frequency. For 58: 2554: 1942: 694: 503:
compulsions. The forbidden thoughts factor correlates highly with intrusive thoughts of a violent, religious, or sexual nature. The cleaning factor correlates highly with obsessions about contamination and compulsions related to cleaning. The hoarding factor only involves hoarding-related obsessions and compulsions, and was identified as being distinct from other symptom groupings.
1168:. In cases in which OCD develops during childhood, there is a much stronger familial link in the disorder than with cases in which OCD develops later in adulthood. In general, genetic factors account for 45–65% of the variability in OCD symptoms in children diagnosed with the disorder. A 2007 study found evidence supporting the possibility of a heritable risk for OCD. 1841:(SNRIs) medication does not effectively treat OCD symptoms, or vice versa, for individuals who begin treatment with psychotherapy. This technique is considered superior to others due to the lack of medication used. However, up to 25% of patients will discontinue treatment due to the severity of their tics. CBT normally lasts anywhere from 12-16 sessions, with 2470:(1709–1784) also had OCD. He had elaborate rituals for crossing the thresholds of doorways, and repeatedly walked up and down staircases counting the steps. He would touch every post on the street as he walked past, only step in the middle of paving stones, and repeatedly perform tasks as though they had not been done properly the first time. 1077:. Between 60 and 80% of those with OCD experience a major depressive episode in their lifetime. Comorbidity rates have been reported at between 19 and 90%, as a result of methodological differences. Between 9–35% of those with bipolar disorder also have OCD, compared to 1–2% in the general population. About 50% of those with OCD experience 1702:, or other licensed mental health professional. OCD, like other mental and behavioral health disorders, cannot be diagnosed by a medical exam, nor are there any medical exams that can predict if one will fall victim to such illnesses. To be diagnosed with OCD, a person must have obsessions, compulsions, or both, according to the 1706:(DSM). The DSM notes that there are multiple characteristics that can turn obsessions and compulsions from normalized behavior to "clinically significant". There has to be recurring and strong thoughts or impulsive that intrude on the day-to-day lives of the patients and cause noticeable levels of anxiousness. 1736:
There are several types of obsessive thoughts that are found commonly in those with OCD. Some of these include fear of germs, hurting loved ones, embarrassment, neatness, societally unacceptable sexual thoughts etc. Within OCD, these specific categories are often diagnosed into their own type of OCD.
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Moreover, the obsessions or compulsions must be time-consuming, often taking up more than one hour per day, or cause impairment in social, occupational, or scholastic functioning. It is helpful to quantify the severity of symptoms and impairment before and during treatment for OCD. In addition to the
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Some medications, toxin exposures, and drugs, such as methamphetamine or cocaine, can induce obsessive-compulsive disorder (OCD) in people without previous symptoms. Some atypical antipsychotics (second-generation antipsychotics) such as olanzapine (Zyprexa) and clozapine (Clozaril) can induce OCD in
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to explain their behavior; however, these rationalizations do not apply to the behavioral pattern, but to each individual occurrence. For example, someone compulsively checking the front door may argue that the time and stress associated with one check is less than the time and stress associated with
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Compulsions occur often and typically take up at least one hour per day, impairing one's quality of life. Compulsions cause relief in the moment, but cause obsessions to grow over time due to the repeated reward-seeking behavior of completing the ritual for relief. Many adults with OCD are aware that
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he said: "I'm obsessive-compulsive. I have very, very strong obsessive-compulsive issues. I'm very particular. ... It's very hard for me, you know? It makes you very addictive in behavior, because routine and ritual become entrenched. But in work, it manifests itself in obsessive attention to detail
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attributed obsessive–compulsive behavior to unconscious conflicts that manifest as symptoms. Freud describes the clinical history of a typical case of "touching phobia" as starting in early childhood, when the person has a strong desire to touch an item. In response, the person develops an "external
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Obsessive–compulsive disorder affects about 2.3% of people at some point in their life, with the yearly rate about 1.2%. OCD occurs worldwide. It is unusual for symptoms to begin after the age of 35 and half of people develop problems before 20. Males and females are affected about equally. However,
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Although the known causes of OCD in younger age groups range from brain abnormalities to psychological preoccupations, life stress such as bullying and traumatic familial deaths may also contribute to childhood cases of OCD, and acknowledging these stressors can play a role in treating the disorder.
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As a result, people with OCD are often aware that their behavior is not rational, and are unhappy about their obsessions, but nevertheless feel compelled by them. By contrast, people with OCPD are not aware of anything abnormal; they will readily explain why their actions are rational. It is usually
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Approximately 1–2% of children are affected by OCD. There is a lot of similarity between the clinical presentation of OCD in children and adults, and it is considered a highly familial disorder, with a phenotypic heritability of around 50%. Obsessive–compulsive disorder symptoms tend to develop more
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was "effective in the short-term", and found that "here was a small effect-size for risperidone or anti-psychotics in general in the short-term"; however, the study authors found "no evidence for the effectiveness of quetiapine or olanzapine in comparison to placebo." While quetiapine may be useful
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For example, a patient might be asked to touch something very mildly contaminated (exposure), and wash their hands only once afterward (response prevention). Another example might entail asking the patient to leave the house and check the lock only once (exposure), without going back to check again
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A different aspect of the diagnoses is the degree of insight had by the individual in regards to the truth of the obsessions. There are three levels, good/fair, poor and absent/delusional. Good/fair indicated that the patient is aware that the obsessions they have are not true or probably not true.
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Historically, OVI has been thought to be linked to poorer treatment outcome in patients with OCD, but it is currently considered a poor indicator of prognosis. The Overvalued Ideas Scale (OVIS) has been developed as a reliable quantitative method of measuring levels of OVI in patients with OCD, and
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Some people with OCD perform compulsive rituals because they inexplicably feel that they must do so, while others act compulsively to mitigate the anxiety that stems from obsessive thoughts. The affected individual might feel that these actions will either prevent a dreaded event from occurring, or
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SSRIs are a second-line treatment of adult OCD with mild functional impairment, and as first-line treatment for those with moderate or severe impairment. In children, SSRIs can be considered as a second-line therapy in those with moderate to severe impairment, with close monitoring for psychiatric
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The recent development of remotely technology-delivered CBT is increasing access to therapy options for those living with OCD and remote versions appear to equally as effective as in-person therapy options. The development of smartphone interventions for OCD that utilize CBT techniques are another
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Compulsions become clinically significant when a person feels driven to perform them in response to an obsession, or according to rules that must be applied rigidly, and when the person consequently feels or causes significant distress. Therefore, while many people who do not have OCD may perform
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In regards to the cause of onset, researchers asked participants in one study what they felt was responsible for triggering the initial onset of their illness. 29% of patients answered that there was an environmental factor in their life that did so. Specifically, the majority of participants who
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Al-Balkhi describes obsessions particular to the disorder as "Annoying thoughts that are not real. These intrusive thoughts prevent enjoying life, and performing daily activities. They affect concentration and interfere with ability to carry out different tasks." As treatment, Al-Balkhi suggests
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mystical text from the late 14th century, recommends dealing with recurring obsessions by attempting to ignore them, and, if that fails, to "cower under them like a poor wretch and a coward overcome in battle, and reckon it to be a waste of your time for you to strive any longer against them", a
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Another model proposes that affective dysregulation links excessive reliance on habit-based action selection with compulsions. This is supported by the observation that those with OCD demonstrate decreased activation of the ventral striatum when anticipating monetary reward, as well as increased
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with the heightened levels of anxiety. However, drug addiction among people with OCD may be a compulsive behavior. Depression is also extremely prevalent among people with OCD. One explanation for the high depression rate among OCD populations was posited by Mineka, Watson, and Clark (1998), who
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The Children's Yale–Brown Obsessive–Compulsive Scale (CY-BOCS) is the gold standard measure for assessment of pediatric OCD. It follows the Y-BOCS format, but with a Symptom Checklist that is adapted for developmental appropriateness. Insight, avoidance, indecisiveness, responsibility, pervasive
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is reduced across all domains in OCD. While psychological or pharmacological treatment can lead to a reduction of OCD symptoms and an increase in reported quality of life, symptoms may persist at moderate levels even following adequate treatment courses, and completely symptom-free periods are
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Therapeutic treatment may be effective in reducing ritual behaviors of OCD for children and adolescents. Similar to the treatment of adults with OCD, cognitive behavioral therapy stands as an effective and validated first line of treatment of OCD in children. Family involvement, in the form of
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There has been a significant amount of progress over the last few decades, and as of 2022 there is statically significant improvement in the diagnostic process for individuals with OCD. One study found that of two groups of individuals, one with participants under the age of 27.25 and one with
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Psychotherapy in combination with psychiatric medication may be more effective than either option alone for individuals with severe OCD. ERP coupled with weight restoration and serotonin reuptake inhibitors has proven the most effective when treating OCD and an eating disorder simultaneously.
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structures of the brain in patients with OCD. There appears to be a connection between the OCD symptoms and abnormalities in certain areas of the brain, but such a connection is not clear. Some people with OCD have areas of unusually high activity in their brain, or low levels of the chemical
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People with OCD rely on compulsions as an escape from their obsessive thoughts; however, they are aware that relief is only temporary, and that intrusive thoughts will return. Some affected individuals use compulsions to avoid situations that may trigger obsessions. Compulsions may be actions
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Common compulsions may include hand washing, cleaning, checking things (such as locks on doors), repeating actions (such as repeatedly turning on and off switches), ordering items in a certain way, and requesting reassurance. Although some individuals perform actions repeatedly, they do not
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It has been found that between 18 and 34% of females currently experiencing OCD scored positively on an inventory measuring disordered eating. Another study found that 7% are likely to have an eating disorder, while another found that fewer than 5% of males have OCD and an eating disorder.
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When looking into the onset of OCD, one study suggests that there are differences in the age of onset between males and females, with the average age of onset of OCD being 9.6 for male children and 11.0 for female children. Children with OCD often have other mental disorders, such as ADHD,
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review of symptom structures found a four-factor grouping structure to be most reliable: symmetry factor, forbidden thoughts factor, cleaning factor, and hoarding factor. The symmetry factor correlates highly with obsessions related to ordering, counting, and symmetry, as well as repeating
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ERP has a strong evidence base, and is considered the most effective treatment for OCD. However, this claim was doubted by some researchers in 2000, who criticized the quality of many studies. While ERP can lead a majority of clients to improvements, many do not reach remission or become
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From the observation of the efficacy of antidepressants in OCD, a serotonin hypothesis of OCD has been formulated. Studies of peripheral markers of serotonin, as well as challenges with proserotonergic compounds have yielded inconsistent results, including evidence pointing towards basal
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binding potentials that were normalized by treatment with SSRIs. Despite inconsistencies in the types of abnormalities found, evidence points towards dysfunction of serotonergic systems in OCD. Orbitofrontal cortex overactivity is attenuated in people who have successfully responded to
753:(such as head banging, body rocking, or self-biting), which are usually not as complex and not precipitated by obsessions. It can sometimes be difficult to tell the difference between compulsions and complex tics, and about 10–40% of people with OCD also have a lifetime tic disorder. 678:
might be inclined to treat inorganic matter as if it had the sentience or rights of living organisms, despite accepting that such behavior is irrational on an intellectual level. There is debate as to whether hoarding should be considered an independent syndrome from OCD.
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is no better than placebo with regard to primary outcomes, but small effects were found in terms of Y-BOCS score. The efficacy of quetiapine and olanzapine are limited by an insufficient number of studies. A 2014 review article found two studies that indicated that
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Pediatric OCD Treatment Study (POTS) Team (27 October 2004). "Cognitive-Behavior Therapy, Sertraline, and Their Combination for Children and Adolescents With Obsessive-Compulsive Disorder: The Pediatric OCD Treatment Study (POTS) Randomized Controlled Trial".
839:(ERP) on such people, as they may be unwilling to cooperate, at least initially. Similar to how insight is identified on a continuum, obsessive-compulsive beliefs are characterized on a spectrum, ranging from obsessive doubt to delusional conviction. In the 12095: 2454:, displayed symptoms of OCD (which had not yet been named). During the most severe period of his condition, he would mutter the same phrase over and over again to himself while rocking back and forth. He later described his obsessions in his autobiography 1171:
Research has found there to be a genetic correlation between anorexia nervosa and OCD, suggesting a strong etiology. First and second hand relatives of probands with OCD have a greater risk of developing anorexia nervosa as genetic relatedness increases.
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comparing washing and checking symptoms reported that washers outperformed checkers on eight out of ten cognitive tests. The symptom dimension of contamination and cleaning may be associated with higher scores on tests of inhibition and verbal memory.
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stated that he had OCD, saying: "I have an obsessive–compulsive disorder that's completely under control. Thank God I've been able to undergo treatment and it doesn't make me unable to carry out my responsibilities as the President of the Republic."
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assigned to the patient in between meetings with a therapist. (Lack 2012). Modalities differ in ERP treatment but both virtual reality based as well as unguided computer assisted treatment programs have shown effective results in treatment programs.
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thought pattern, and occurs in about 4% of people with OCD. When cases of OCD with no insight become severe, affected individuals have an unshakable belief in the reality of their delusions, which can make their cases difficult to differentiate from
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findings and treatment response, though neuroimaging studies have not been comprehensive enough to draw conclusions. Subtype-dependent treatment response has been studied, and the hoarding subtype has consistently been least responsive to treatment.
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gyri. These findings contrast with those in people with other anxiety disorders, who evince decreased (rather than increased) grey matter volumes in bilateral lenticular/caudate nuclei, as well as decreased grey matter volumes in bilateral dorsal
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augmentation. While SSRIs continue to be first-line, recent data for treatment-resistant OCD supports adjunctive use of neuroleptic medications, deep-brain stimulation, and neurosurgical ablation. There is growing evidence to support the use of
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contact with people of any age. Similar to other intrusive thoughts or images, some disquieting sexual thoughts are normal at times, but people with OCD may attach extraordinary significance to such thoughts. For example, obsessive fears about
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exposed two hospitalized patients to anxiety-inducing situations while preventing them from performing any compulsions. Eventually, both patients' anxiety level dropped to manageable levels. Meyer devised this procedure from his analysis of
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published a systematic review of 24 studies researching associations between internet gaming disorder (IGD) and various psychopathologies that found a significant correlation between IGD and obsessive–compulsive disorder symptoms in 3 of 4
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Jones AM, De Nadai AS, Arnold EB, McGuire JF, Lewin AB, Murphy TK, et al. (February 2013). "Psychometric properties of the obsessive compulsive inventory: child version in children and adolescents with obsessive-compulsive disorder".
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of OCD symptoms, studies differentiating various symptoms have been performed. Symptom-specific neuroimaging abnormalities include the hyperactivity of caudate and ACC in checking rituals, while finding increased activity of cortical and
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remained the dominant treatment for OCD until the mid-1980s, even though medicinal and therapeutic treatments were known and available, because it was widely thought that these treatments would be detrimental to the effectiveness of the
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frequently in children 10–14 years of age, with males displaying symptoms at an earlier age, and at a more severe level than females. In children, symptoms can be grouped into at least four types, including sporadic and tic-related OCD.
2281:" consulting an older monk, who told him: "My son, I take upon myself all the sins which these temptations have led you, or may lead you, to commit. All I require of you is that for the future you pay no attention to them whatsoever." 7819:
Stewart SE, Mayerfeld C, Arnold PD, Crane JR, O'Dushlaine C, Fagerness JA, et al. (June 2013). "Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1".
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Some parts of the brain showing abnormal activity in OCD: Orbitofrontal cortex integrates rewards, emotions, and behaviors; anterior cingulate cortex is involved in error detection; amygdala is involved in emotional interpretation of
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Perera MP, Mallawaarachchi S, Miljevic A, Bailey NW, Herring SE, Fitzgerald PB (October 2021). "Repetitive Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: A Meta-analysis of Randomized, Sham-Controlled Trials".
11773: 6407:"A Meta-analysis of Cognitive Behavior Therapy and Medication for Child Obsessive-compulsive Disorder: Moderators of Treatment Efficacy, Response, and Remission: Research Article: Treatment Outcomes and Moderators in Pediatric OCD" 7962:"Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder" 2326:. The vast majority of people who thought that they were possessed by the devil did not have hallucinations or other "spectacular symptoms" but "complained of anxiety, religious fears, and evil thoughts." In 1584, a woman from 8668:
Rasgon A, Lee WH, Leibu E, Laird A, Glahn D, Goodman W, et al. (October 2017). "Neural correlates of affective and non-affective cognition in obsessive compulsive disorder: A meta-analysis of functional imaging studies".
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Another criterion in the DSM is that a person's mental illness does not fit one of the other categories of a mental disorder better. That is to say, if the obsessions and compulsions of a patient could be better described by
843:, overvalued ideation (OVI) is considered most akin to poor insight—especially when considering belief strength as one of an idea's key identifiers. Furthermore, severe and frequent overvalued ideas are considered similar to 614:, the pathological guilt/anxiety about moral or religious issues. In scrupulosity, a person's obsessions focus on moral or religious fears, such as the fear of being an evil person or the fear of divine retribution for sin. 10272:
Aardema, F., O'Connor, K. P., Emmelkamp, P. M., Marchand, A., & Todorov, C. (2005). Inferential confusion in obsessive-compulsive disorder: the inferential confusion questionnaire. Behaviour Research & Therapy, 43,
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with exposure and ritual/response prevention. Likewise, in the United Kingdom, psychosurgery cannot be performed unless a course of treatment from a suitably qualified cognitive–behavioral therapist has been carried out.
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for treatment-resistant OCD. Atypical antipsychotics are not useful when used alone, and no evidence supports the use of first-generation antipsychotics. For OCD treatment specifically, there is tentative evidence for
436:, are more effective than non-CBT interventions. SSRIs are more effective when used in excess of the recommended depression dosage; however, higher doses can increase side effect intensity. Commonly used SSRIs include 7683:
Bloch MH, Landeros-Weisenberger A, Sen S, Dombrowski P, Kelmendi B, Coric V, et al. (September 2008). "Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review".
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In regards to diagnosing, the health professional also looks to make sure that the signs of obsessions and compulsions are not the results of any drugs, prescription or recreational, that the patient may be taking.
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There are several different types of tics that have been observed in individuals with OCD. These include but are not limited to, "grunting", "jerking" or "shrugging" body parts, sniffling, and excessive blinking.
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Though OCD was once believed to be associated with above-average intelligence, this does not appear to necessarily be the case. A 2013 review reported that people with OCD may sometimes have mild but wide-ranging
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Generally, two categories of models for OCD have been postulated. The first category involves deficits in executive dysfunction and is based on the observed structural and functional abnormalities in the dlPFC,
725:. Some individuals with OCD are aware that their behaviors are not rational, but they feel compelled to follow through with them to fend off feelings of panic or dread. Furthermore, compulsions often stem from 270:, and the fear of possibly harming others or themselves. Compulsions are repeated actions or routines that occur in response to obsessions to achieve a relief from anxiety. Common compulsions include excessive 1729:(Y-BOCS; expert rating) or the obsessive-compulsive inventory (OCI-R; self-rating). With measurements such as these, psychiatric consultation can be more appropriately determined, as it has been standardized. 493:
OCD can present with a wide variety of symptoms. Certain groups of symptoms usually occur together as dimensions or clusters, which may reflect an underlying process. The standard assessment tool for OCD, the
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person's estimate of the time spent each day harboring obsessive-compulsive thoughts or behaviors, concrete tools can be used to gauge the person's condition. This may be done with rating scales, such as the
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prohibition" against this type of touching. However, this "prohibition does not succeed in abolishing" the desire to touch; all it can do is repress the desire and "force it into the unconscious." Freudian
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Most people with OCD understand that their thoughts do not correspond with reality; however, they feel that they must act as though these ideas are correct or realistic. For example, someone who engages in
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Pooley EC, Fineberg N, Harrison PJ (June 2007). "The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis".
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was effective in treating OCD. Many reports of its success in treatment followed, and several studies had confirmed its effectiveness by the 1980s. However, clomipramine was subsequently displaced by new
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2) The onset of symptoms cannot be explained by an obsessive-compulsive and related disorder that is not substance/medication-induced and should last for a substantial period of time (about 1 month)
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Obsessive–compulsive disorder affects about 2.3% of people at some point in their lives, while rates during any given year are about 1.2%. More than three million Americans suffer from OCD. According to
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Movies and television shows may portray idealized or incomplete representations of disorders such as OCD. Compassionate and accurate literary and on-screen depictions may help counteract the potential
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OCD is chronic and long-lasting with periods of severe symptoms followed by periods of improvement. Treatment can improve ability to function and quality of life, and is usually reflected by improved
286:, neutralizing, seeking assurance, praying, and checking things. People with OCD may only perform mental compulsions such as needing to know or remember things. While this is sometimes referred to as 1850:(response prevention). After succeeding at one stage of treatment, the patient's level of discomfort in the exposure phase can be increased. When this therapy is successful, the patient will quickly 807:
OCD sometimes manifests without overt compulsions, which may be termed "primarily obsessional OCD." OCD without overt compulsions could, by one estimate, characterize as many as 50–60% of OCD cases.
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being robbed, and checking is consequently the better option. This reasoning often occurs in a cyclical manner, and can continue for as long as the affected person needs it to in order to feel safe.
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Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, et al. (November 2003). "Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype".
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Geller DA, Biederman J, Stewart SE, Mullin B, Martin A, Spencer T, et al. (November 2003). "Which SSRI? A Meta-Analysis of Pharmacotherapy Trials in Pediatric Obsessive-Compulsive Disorder".
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Radua J, van den Heuvel OA, Surguladze S, Mataix-Cols D (July 2010). "Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders".
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O'Connor, K., Aardema, F., & Pelissier, M.-C. (2005). Beyond reasonable doubt: Reasoning processes in obsessive-compulsive disorder and related disorders. Chichester: John Wiley & Sons.
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for OCD is a treatment of last resort, and will not be performed until the person has failed several attempts at medication (at the full dosage) with augmentation, and many months of intensive
9844:"The Effectiveness of Virtual Reality Exposure-Based Cognitive Behavioral Therapy for Severe Anxiety Disorders, Obsessive-Compulsive Disorder, and Posttraumatic Stress Disorder: Meta-analysis" 1982:, so this treatment is qualified as efficacious. Efficacy has been demonstrated both in short-term (6–24 weeks) treatment trials, and in discontinuation trials with durations of 28–52 weeks. 1752:, it would not be diagnosed as OCD. That being said, OCD does often go hand in hand with other mental disorders. For this reason, one may be diagnosed with multiple mental disorders at once. 606:—will harm either the patient or the people or things the patient cares about. Others with OCD may experience the sensation of invisible protrusions emanating from their bodies, or feel that 11522: 4630:
McKay D, Abramowitz JS, Calamari JE, Kyrios M, Radomsky A, Sookman D, et al. (July 2004). "A critical evaluation of obsessive-compulsive disorder subtypes: symptoms versus mechanisms".
3696:
Alonso P, Segalàs C, Real E, Pertusa A, Labad J, Jiménez-Murcia S, et al. (August 2010). "Suicide in patients treated for obsessive-compulsive disorder: a prospective follow-up study".
5574:
Sarris J, Camfield D, Berk M (May 2012). "Complementary medicine, self-help, and lifestyle interventions for obsessive compulsive disorder (OCD) and the OCD spectrum: a systematic review".
3613:
Starcevic V, Eslick GD, Viswasam K, Berle D (December 2020). "Symptoms of Obsessive-Compulsive Disorder during Pregnancy and the Postpartum Period: a Systematic Review and Meta-Analysis".
8809:
Piras F, Piras F, Chiapponi C, Girardi P, Caltagirone C, Spalletta G (January 2015). "Widespread structural brain changes in OCD: a systematic review of voxel-based morphometry studies".
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1) General OCD symptoms (obsessions, compulsions, skin picking, hair pulling, etc.) that developed soon after exposure to the substance or medication which can produce such symptoms.
3972:
Gava I, Barbui C, Aguglia E, Carlino D, Churchill R, De Vanna M, et al. (April 2007). "Psychological treatments versus treatment as usual for obsessive compulsive disorder (OCD)".
2492:
is known to have had OCD, primarily an obsessive fear of germs and contamination. Friends of Hughes have also mentioned his obsession with minor flaws in clothing. This was conveyed in
847:, which are so rigidly held by, and so important to affected individuals, that they end up becoming a defining identity. In adolescent OCD patients, OVI is considered a severe symptom. 9441:
Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. (November 1989). "The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability".
5915:
Neziroglu F, McKay D, Yaryura-Tobias JA, Stevens KP, Todaro J (September 1999). "The Overvalued Ideas Scale: development, reliability and validity in obsessive-compulsive disorder".
5164:
Hermans D, Engelen U, Grouwels L, Joos E, Lemmens J, Pieters G (January 2008). "Cognitive confidence in obsessive-compulsive disorder: distrusting perception, attention and memory".
1568:
fear-extinction tasks, hyperresponsiveness in the amygdala to fearful stimuli, and hyporesponsiveness in the amygdala when exposed to positively valanced stimuli. Stimulation of the
7505:
Lee EB, Barney JL, Twohig MP, Lensegrav-Benson T, Quakenbush B (April 2020). "Obsessive compulsive disorder and thought action fusion: Relationships with eating disorder outcomes".
944:
CBT is the first line treatment for mild to moderate cases of OCD in children, while medication plus CBT is recommended for moderate to severe cases. Serotonin reuptake inhibitors (
294:
their compulsions do not make sense, but they still perform them to relieve the distress caused by obsessions. For this reason, thoughts and behaviors in OCD are usually considered
12757: 9958:"People with obsessive-compulsive disorder often remain symptomatic following psychological treatment: A clinical significance analysis of manualised psychological interventions" 14882: 1901:
found that psychological interventions derived from CBT models, such as ERP, ACT, and IBT, were more effective than non-CBT interventions. Other forms of psychotherapy, such as
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Foa EB, Huppert JD, Leiberg S, Langner R, Kichic R, Hajcak G, et al. (December 2002). "The Obsessive-Compulsive Inventory: development and validation of a short version".
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specifically developed for treating OCD. The therapy posits that individuals with OCD put a greater emphasis on an imagined possibility than on what can be perceived with the
12113: 2124:. The risk of having at least one comorbid personality disorder in OCD is 52%, which is the highest among anxiety disorders and greatly impacts its management and prognosis. 1521:
and thalamus. The second category involves dysfunctional modulatory control and primarily relies on observed functional and structural differences in the ACC, mPFC, and OFC.
1460:
loop in OCD, as well as the high rates of comorbidity between OCD and ADHD, have led some to draw a link in their mechanism. Observed similarities include dysfunction of the
15079: 10893:
Pignon B, Tezenas du Montcel C, Carton L, Pelissolo A (November 2017). "The Place of Antipsychotics in the Therapy of Anxiety Disorders and Obsessive-Compulsive Disorders".
5459: 2075:. However, because deep brain stimulation results in such an instant and intense change, individuals may experience identity challenges afterward. In the United States, the 1717:
such obsessions, neutralize them with another thought or action, or try to rationalize their anxiety away. People with OCD tend to recognize their obsessions as irrational.
1629:, may improve some cases of OCD, they frequently exacerbate others. Antipsychotics, in the low doses used to treat OCD, may actually increase the release of dopamine in the 670:. Furthermore, the doubt that accompanies OCD leads to uncertainty regarding whether one might act on the troubling thoughts, resulting in self-criticism or self-loathing. 1262:
may have had evolutionary advantages. In this view, OCD may be the extreme statistical tail of such behaviors, possibly the result of a high number of predisposing genes.
14236: 10303:"Evaluation of Inference-Based Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder: A Multicenter Randomized Controlled Trial with Three Treatment Modalities" 10664:"Efficacy and acceptability of pharmacological, psychosocial, and brain stimulation interventions in children and adolescents with mental disorders: an umbrella review" 1034:
Someone exhibiting OCD signs does not necessarily have OCD. Behaviors that present as obsessive–compulsive can also be found in a number of other conditions, including
377:. Personality disorders are a common comorbidity, with schizotypal and OCPD having poor treatment response. The condition is also associated with a general increase in 1472:, and may explain the high degree of comorbidity. Decreased volumes of the dorsolateral prefrontal cortex related to executive function has also been observed in OCD. 10836: 9379:"Reduction of N-acetylaspartate in the medial prefrontal cortex correlated with symptom severity in obsessive-compulsive disorder: meta-analyses of (1)H-MRS studies" 389:, absorbed, or otherwise fixated. However, the actual disorder can vary in presentation, and individuals with OCD may not be concerned with cleanliness or symmetry. 12533:
Camfield DA, Sarris J, Berk M (June 2011). "Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): a review of mechanistic and clinical evidence".
1409:. However, an older meta-analysis of functional neuroimaging in OCD reported that the only consistent functional neuroimaging finding was increased activity in the 13435: 10013:"Serious negative consequences associated with exposure and response prevention for obsessive-compulsive disorder: A survey of therapist attitudes and experiences" 6114:
Leopold R, Backenstrass M (March 2015). "Neuropsychological differences between obsessive-compulsive washers and checkers: a systematic review and meta-analysis".
1164:
more often affected than fraternal twins. Furthermore, individuals with OCD are more likely to have first-degree family members exhibiting the same disorders than
11336:
Eddy KT, Dutra L, Bradley R, Westen D (December 2004). "A multidimensional meta-analysis of psychotherapy and pharmacotherapy for obsessive-compulsive disorder".
2382:. In the mid-1980s, this approach changed, and practitioners began treating OCD primarily with medicine and practical therapy rather than through psychoanalysis. 1657:
after deep brain stimulation correlates with improvement in symptoms, pointing to reduced dopamine release in the striatum playing a role in generating symptoms.
1247:(COMT) has been inconsistent, with one meta-analysis reporting a significant association, albeit only in men, and another meta analysis reporting no association. 10070:"Obsessive-compulsive disorder-contamination fears, features, and treatment:novel smartphone therapies in light of global mental health and pandemics (COVID-19)" 2959: 2506: 287: 12279: 11379:
Subramaniam M, Soh P, Vaingankar JA, Picco L, Chong SA (May 2013). "Quality of life in obsessive-compulsive disorder: impact of the disorder and of treatment".
5950:
Abramovitch A, Anholt G, Raveh-Gottfried S, Hamo N, Abramowitz JS (March 2018). "Meta-Analysis of Intelligence Quotient (IQ) in Obsessive-Compulsive Disorder".
2653:, teenage main character Aza Holmes struggles with OCD that manifests as a fear of the human microbiome. Throughout the story, Aza repeatedly opens an unhealed 7917:
Azzam A, Mathews CA (November 2003). "Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder".
1764:
participants over that age, those in the younger group experienced a significantly faster time between the onset of OCD tendencies and their formal diagnoses.
10389:"Pharmacological and psychotherapeutic interventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis" 9793:"Unguided Computer-Assisted Self-Help Interventions Without Human Contact in Patients With Obsessive-Compulsive Disorder: Systematic Review and Meta-analysis" 7597:
Meier M, Kossakowski JJ, Jones PJ, Kay B, Riemann BC, McNally RJ (March 2020). "Obsessive-compulsive symptoms in eating disorders: A network investigation".
1703: 1544:
regions in contamination-related symptoms. Neuroimaging differentiating content of intrusive thoughts has found differences between aggressive as opposed to
884:, while auditory attention was not significantly affected. People with OCD show impairment in formulating an organizational strategy for coding information, 1333:
OCD may be more common in people who have been bullied, abused, or neglected, and it sometimes starts after a significant life event, such as childbirth or
10358:
Koran LM, Hanna GL, Hollander E, Nestadt G, Simpson HB (July 2007). "Practice guideline for the treatment of patients with obsessive-compulsive disorder".
12363: 4967: 4753:
Doron G, Szepsenwol O, Karp E, Gal N (December 2013). "Obsessing about intimate-relationships: testing the double relationship-vulnerability hypothesis".
1468:, as well as shared deficits in executive functions. The involvement of the orbitofrontal cortex and dorsolateral prefrontal cortex in OCD is shared with 6701:
Angelakis I, Gooding P, Tarrier N, Panagioti M (July 2015). "Suicidality in obsessive compulsive disorder (OCD): a systematic review and meta-analysis".
3061:
Angelakis I, Gooding P, Tarrier N, Panagioti M (July 2015). "Suicidality in obsessive compulsive disorder (OCD): a systematic review and meta-analysis".
2675: 586:
Obsessions are stress-inducing thoughts that recur and persist, despite efforts to ignore or confront them. People with OCD frequently perform tasks, or
565: 5480:
van den Hout M, Kindt M (June 2004). "Obsessive-compulsive disorder and the paradoxical effects of perseverative behaviour on experienced uncertainty".
4886:
Huppert JD, Siev J, Kushner ES (October 2007). "When religion and obsessive-compulsive disorder collide: treating scrupulosity in Ultra-Orthodox Jews".
12188: 5140: 2794: 15072: 12456: 10291:
O'Connor, K., & Aardema, F. (2012). Clinician's handbook for obsessive compulsive disorder: Inference-based therapy. Chichester: Wiley-Blackwell.
1996: 10861: 1572:
has also been observed to effectively alleviate both obsessions and compulsions, supporting the role of affective dysregulation in generating both.
12508: 10577: 6071:
Pauls DL, Abramovitch A, Rauch SL, Geller DA (June 2014). "Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective".
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in aggressive symptoms, while observing increased connectivity between the ventral striatum and insula in sexual or religious intrusive thoughts.
14915: 14229: 4339:
Fawcett EJ, Power H, Fawcett JM (23 June 2020). "Women Are at Greater Risk of OCD Than Men: A Meta-Analytic Review of OCD Prevalence Worldwide".
2023: 1954: 1838: 1674:, less consistent abnormalities observed in neuroimaging studies, and the efficacy of some glutamatergic drugs (such as the glutamate-inhibiting 1254:
that moderate versions of compulsive behavior may have had evolutionary advantages. Examples would be moderate constant checking of hygiene, the
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Many organizations and charities around the world advocate for the wellbeing of people with OCD, stigma reduction, research, and awareness. The
290:(Pure O), it is also considered a misnomer due to associated mental compulsions and reassurance seeking behaviors that are consistent with OCD. 14862: 11637: 5837:
Borda T, Neziroglu F, Taboas W, McKay D, Frenkiel L (September 2017). "Overvalued ideation in adolescents with obsessive-compulsive disorder".
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use to communicate with each other, and is thought to be involved in regulating many functions, influencing emotions, mood, memory, and sleep.
591: 6454:
McGuire JF, Lewin AB, Horng B, Murphy TK, Storch EA (January 2012). "The Nature, Assessment, and Treatment of Obsessive–Compulsive Disorder".
2314:
From the 14th to the 16th century in Europe, it was believed that people who experienced blasphemous, sexual or other obsessive thoughts were
14837: 9125:"From Thought to Action: How the Interplay Between Neuroscience and Phenomenology Changed Our Understanding of Obsessive-Compulsive Disorder" 2259: 2026:
in treatment-resistant OCD, these drugs are often poorly tolerated, and have metabolic side effects that limit their use. A guideline by the
1773: 1428:, habit, goal-directed behavior, self-referential thinking, and cognitive control. For nonaffective tasks, hyperactivity was observed in the 1035: 374: 350: 179: 33: 17: 12425: 10936:
Komossa K, Depping AM, Meyer M, Kissling W, Leucht S (December 2010). "Second-generation antipsychotics for obsessive compulsive disorder".
15065: 14978: 14274: 12402: 1350: 474: 2748:. Research on the potential for other supplements, such as milk thistle, to help with OCD and various neurological disorders, is ongoing. 653:" with "strangers, acquaintances, parents, children, family members, friends, coworkers, animals, and religious figures", and can include 1457: 1302:
A controversial hypothesis is that some cases of rapid onset of OCD in children and adolescents may be caused by a syndrome connected to
309:
Although the exact cause of OCD is unknown, several regions of the brain have been implicated in its neuroanatomical model including the
9751:
Carter, K. "Obsessive–compulsive personality disorder." PSYC 210 lecture: Oxford College of Emory University. Oxford, GA. 11 April 2006.
6965: 4195:"Repetitive transcranial magnetic stimulation for obsessive-compulsive disorder: A systematic review and pairwise/network meta-analysis" 15508: 14819: 14222: 13907: 13863: 12966: 11167: 8406:
Despite continued research in the field, the relationship between GAS and specific neuropsychiatric disorders (PANDAS) remains elusive.
7727:
Lin PY (April 2007). "Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder".
6497:
Watson HJ, Rees CS (May 2008). "Meta-analysis of randomized, controlled treatment trials for pediatric obsessive-compulsive disorder".
3364: 3165:"Atypical antipsychotic augmentation in SSRI treatment refractory obsessive-compulsive disorder: a systematic review and meta-analysis" 4488:
Swedo SE (1 April 1989). "Obsessive-Compulsive Disorder in Children and Adolescents: Clinical Phenomenology of 70 Consecutive Cases".
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on her finger to drain out what she believes are pathogens. The novel is based on Green's own experiences with OCD. He explained that
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in the mPFC, which is thought to reflect neuron density or functionality, although the exact interpretation has not been established.
895:
Specific subtypes of symptom dimensions in OCD have been associated with specific cognitive deficits. For example, the results of one
349:. Diagnosis is based on clinical presentation and requires ruling out other drug-related or medical causes; rating scales such as the 14264: 10126:"Increasing willingness to experience obsessions: acceptance and commitment therapy as a treatment for obsessive-compulsive disorder" 9549:
Starcevic V, Janca A (January 2011). "Obsessive-compulsive spectrum disorders: still in search of the concept-affirming boundaries".
9176:
Neuropsychopharmacology: the fifth generation of progress: an official publication of the American College of Neuropsychopharmacology
8625:
Whiteside SP, Port JD, Abramowitz JS (November 2004). "A meta-analysis of functional neuroimaging in obsessive-compulsive disorder".
5391:"Hygiene of the Skin: When Is Clean Too Clean? Subtopic: "Skin Barrier Properties and Effect of Hand Hygiene Practices", Paragraph 5" 1876:
strategies to teach patients not to overreact to or avoid unpleasant thoughts and feelings but rather "move toward valued behavior."
1726: 495: 299: 1969:
SSRIs help people with OCD by inhibiting the reabsorption of serotonin by the nerve cells after they carry messages from neurons to
1868:(ACT), a newer therapy also used to treat anxiety and depression, has also been found to be effective in treatment of OCD. ACT uses 15293: 13722: 13339: 13152: 10282:
O'Connor, K. (2002). Intrusions and inferences in obsessive compulsive disorder. Clinical Psychology & Psychotherapy, 9, 38-46.
9261:"A Framework for Understanding the Emerging Role of Corticolimbic-Ventral Striatal Networks in OCD-Associated Repetitive Behaviors" 9025:"A Framework for Understanding the Emerging Role of Corticolimbic-Ventral Striatal Networks in OCD-Associated Repetitive Behaviors" 8038: 5536:
Himle MB, Flessner CA, Woods DW (2004). "Advances in the behavior analytic treatment of trichotillomania and Tourette's Syndrome".
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The cause of OCD is unknown. Both environmental and genetic factors are believed to play a role. Risk factors include a history of
1050:). Some cases of OCD present symptoms typically associated with Tourette syndrome, such as compulsions that may appear to resemble 539: 12482: 9766:"Obsessive-compulsive disorder: Core interventions in the treatment of obsessive-compulsive disorder and body dysmorphic disorder" 6178:"Association between Internet Gaming Disorder or Pathological Video-Game Use and Comorbid Psychopathology: A Comprehensive Review" 14943: 13132: 3780:
Bynum WF, Porter R, Shepherd M (1985). "Obsessional Disorders: A Conceptual History. Terminological and Classificatory Issues.".
2456: 1222: 11957: 4667:"Autism and ADHD symptoms in patients with OCD: are they associated with specific OC symptom dimensions or OC symptom severity?" 709:
or distorted that it results in significant distress, either personally, or for those around the affected individual. Excessive
14515: 14259: 13458: 7296:
Lykouras L, Zervas IM, Gournellis R, Malliori M, Rabavilas A (September 2000). "Olanzapine and obsessive-compulsive symptoms".
4154:"Efficacy of deep brain stimulation for treatment-resistant obsessive-compulsive disorder: systematic review and meta-analysis" 2575: 2419: 1950: 1834: 1110: 1015:
at a substantially higher rate than the general public. Moreover, severe OCD symptoms are consistently associated with greater
193: 12576:
Davidson J, Bjorgvinsson T (June 2003). "Current and potential pharmacological treatments for obsessive-compulsive disorder".
12073: 6149:
Abramovitch A, Cooperman A (April 2015). "The cognitive neuropsychology of obsessive-compulsive disorder: A critical review".
5394: 5343:"Tic-related obsessive-compulsive disorder (OCD): phenomenology and treatment outcome in the Pediatric OCD Treatment Study II" 15423: 12798: 12050: 12015: 11861: 11783: 11666:
Awaad R, Ali S (15 July 2015). "Obsessional Disorders in al-Balkhi's 9th century treatise: Sustenance of the Body and Soul".
11647: 11580: 11553: 10237: 9208: 9183: 8519: 8372:
Shulman ST (February 2009). "Pediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS): update".
5666: 5218: 4834: 4801: 3793: 3042: 1784:. As egodystonic disorders go against a person's self-concept, they tend to cause much distress. OCPD, on the other hand, is 1314:
autoimmune process. The PANDAS hypothesis is unconfirmed and unsupported by data, and two new categories have been proposed:
916: 12281:
Turn box office movies into mental health opportunities: A literature review and resource guide for clinicians and educators
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Muller CP, Jacobs BL, Dijk A, Klompmakers A, Deny D (2009). "4.4 The Serotonergic System in Obsessive-Compulsive Disorder".
2720:
Much current research is devoted to the therapeutic potential of the agents that affect the release of the neurotransmitter
1019:. Reduced total sleep time and sleep efficiency have been observed in people with OCD, with delayed sleep onset and offset. 14371: 9076:"Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings" 8942:
Friedlander L, Desrocher M (January 2006). "Neuroimaging studies of obsessive-compulsive disorder in adults and children".
8586:"Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies" 4109:
Hirschtritt ME, Bloch MH, Mathews CA (4 April 2017). "Obsessive-Compulsive Disorder: Advances in Diagnosis and Treatment".
1790:, marked by the person's acceptance that the characteristics and behaviors displayed as a result are compatible with their 12781: 8012: 3293: 2545:
shared details about his compelling cleaning rituals, need for symmetry in the fridge, and the impact of OCD on his life.
15088: 14908: 13919: 13067: 12870: 12776: 12253: 10485:
Hirschtritt ME, Bloch MH, Mathews CA (April 2017). "Obsessive-Compulsive Disorder: Advances in Diagnosis and Treatment".
7157:"Impact of adverse childhood experiences on the symptom severity of different mental disorders: a cross-diagnostic study" 6658:
Chen YW, Dilsaver SC (November 1995). "Comorbidity for obsessive-compulsive disorder in bipolar and unipolar disorders".
5993:
Shin NY, Lee TY, Kim E, Kwon JS (April 2014). "Cognitive functioning in obsessive-compulsive disorder: a meta-analysis".
3682: 3331: 2705:, may improve OCD symptoms. Administration of opiate treatment may be contraindicated in individuals concurrently taking 2632: 2578:
associated with an OCD diagnosis, and lead to increased public awareness, understanding and sympathy for such disorders.
1978:
adverse effects. Patients treated with SSRIs are about twice as likely to respond to treatment as are those treated with
1026:
and OCD. For example, there is a higher risk of drug addiction among those with any anxiety disorder, likely as a way of
10829: 10760: 1325:
in OCD found an increased risk of having anti-basal ganglia antibodies in those with OCD versus the general population.
13169: 13144: 12979: 12134: 10984: 10613:"Antidepressants in Children and Adolescents: Meta-Review of Efficacy, Tolerability and Suicidality in Acute Treatment" 10360: 9921: 4560:"Age at child obsessive-compulsive disorder onset and its relation to gender, symptom severity, and family functioning" 4440: 2953: 2027: 1424:
A meta-analysis comparing affective and nonaffective tasks observed differences with controls in regions implicated in
2948: 15450: 15335: 14648: 14309: 13955: 13775: 12288: 8893:
Radua J, Grau M, van den Heuvel OA, Thiebaut de Schotten M, Stein DJ, Canales-Rodríguez EJ, et al. (June 2014).
6843:"A prospective study of delayed sleep phase syndrome in patients with severe resistant obsessive-compulsive disorder" 2886: 2820: 2046: 1865: 1741: 722: 429: 12340: 9524: 7029: 6619:"Practice Parameter for the Assessment and Treatment of Children and Adolescents With Obsessive-Compulsive Disorder" 2802: 2402:. The success of ERP clinically and scientifically has been summarized as "spectacular" by prominent OCD researcher 15413: 14657: 14047: 13284: 13255: 13196: 5210: 4974: 4523:
Rasmussen SA, Eisen JL (December 1992). "The epidemiology and clinical features of obsessive compulsive disorder".
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functional connectivity between the VS and the OFC. Furthermore, those with OCD demonstrate reduced performance in
1148:
4) Clinically induces distress or impairment in social, occupational, or other important areas of functioning.
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episodes. OCD is also associated with anxiety disorders. Lifetime comorbidity for OCD has been reported at 22% for
956:
People with OCD may be diagnosed with other conditions as well, such as obsessive–compulsive personality disorder,
781: 511: 425: 370: 12762: 6885:
Paterson JL, Reynolds AC, Ferguson SA, Dawson D (December 2013). "Sleep and obsessive-compulsive disorder (OCD)".
5080:"Obsessive-compulsive disorder and its related disorders: a reappraisal of obsessive-compulsive spectrum concepts" 4249:
Diagnosis and Treatment of Obsessive-Compulsive Disorder in Children and Adolescents (A Systematic Review) | PCORI
15182: 13289: 13084: 13009: 11183: 10711:
Arroll B, Elley CR, Fishman T, Goodyear-Smith FA, Kenealy T, Blashki G, et al. (July 2009). Arroll B (ed.).
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and transporter binding studies have yielded conflicting results, including higher and lower serotonin receptor
15197: 14901: 13942: 13727: 13698: 12959: 12371: 7550:"Obsessions are strongly related to eating disorder symptoms in anorexia nervosa and atypical anorexia nervosa" 5880:
Kozak MJ, Foa EB (March 1994). "Obsessions, overvalued ideas, and delusions in obsessive-compulsive disorder".
3259:"The ICD-10 Classification of Mental and Behavioural Disorders Clinical descriptions and diagnostic guidelines" 2798: 2306:, in a fashion unique to his era and which was not popular in Greek medicine. In his medical treatise entitled 2251: 2055:
may be used as a last resort in people who do not improve with other treatments. In this procedure, a surgical
1557: 1374: 1218: 243:) repeatedly to relieve the distress caused by the obsession, to the extent where it impairs general function. 11734:
Berrios GE (1989). "Obsessive-compulsive disorder: its conceptual history in France during the 19th century".
8337:
Zibordi F, Zorzi G, Carecchio M, Nardocci N (March 2018). "CANS: Childhood acute neuropsychiatric syndromes".
5416:
Pélissier MC, O'Connor KP (March 2002). "Deductive and inductive reasoning in obsessive-compulsive disorder".
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alternative that is expanding access to therapy while allowing therapies to be personalized for each patient.
1798:
impossible to convince them otherwise, and they tend to derive pleasure from their obsessions or compulsions.
13468: 13186: 13162: 8545:"Anti-basal ganglia antibodies in primary obsessive-compulsive disorder: systematic review and meta-analysis" 8467:
Robertson MM (February 2011). "Gilles de la Tourette syndrome: the complexities of phenotype and treatment".
2143: 2080: 1842: 1536: 1528:
leads to improper valuation of behaviors and decreased behavioral control, while the observed alterations in
1116: 750: 12771: 12313: 5131: 4245:"Diagnosis and Treatment of Obsessive-Compulsive Disorder in Children and Adolescents (A Systematic Review)" 3258: 1306:(GABHS), known as pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections ( 15438: 15276: 15136: 14653: 14131: 13668: 13201: 13046: 10387:
Skapinakis P, Caldwell DM, Hollingworth W, Bryden P, Fineberg NA, Salkovskis P, et al. (August 2016).
7106:"Association Between Childhood Maltreatment and Symptoms of Obsessive-Compulsive Disorder: A Meta-Analysis" 4193:
Fitzsimmons SM, van der Werf YD, van Campen AD, Arns M, Sack AT, Hoogendoorn AW, et al. (April 2022).
3816: 2361: 2303: 2138: 2076: 1806: 1244: 1202:, the L allele was associated with OCD. Another meta-analysis observed an increased risk in those with the 1098: 1012: 965: 777: 769: 421: 354: 10528:
Simpson HB, Wetterneck CT, Cahill SP, Steinglass JE, Franklin ME, Leonard RC, et al. (1 March 2013).
9714:
Aardema F, O'Connor K (2003). "Seeing white bears that are not there: Inference processes in obsessions".
5271: 2302:, the 9th century Islamic polymath, was likely the first to classify OCD into different types and pioneer 15109: 14563: 13376: 13174: 10868: 9895:
Huppert & Roth: (2003) Treating Obsessive-Compulsive Disorder with Exposure and Response Prevention.
6792:"Comparative Prevalence of Eating Disorders in Obsessive-Compulsive Disorder and Other Anxiety Disorders" 5769:
Kozak MJ, Foa EB (1994). "Obsessions, overvalued ideas, and delusions in obsessive-compulsive disorder".
4851: 1786: 1777: 303: 295: 14189: 9315:"Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment" 2120:
uncommon. In pediatric OCD, around 40% still have the disorder in adulthood, and around 40% qualify for
385:
is sometimes used in an informal manner unrelated to OCD to describe someone as excessively meticulous,
15513: 15124: 14126: 13041: 11011:
Cybulska EM (February 2006). "Obsessive-compulsive disorder, the brain and electroconvulsive therapy".
2614:) with OCD who opens and closes doors three times while counting aloud before he can walk through them. 2322:. Based on this reasoning, treatment involved banishing the "evil" from the "possessed" person through 1449: 1402: 881: 498:(Y-BOCS), has 13 predefined categories of symptoms. These symptoms fit into three to five groupings. A 386: 12685:"Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight" 10164: 10163:
Twohig MP, Abramowitz JS, Bluett EJ, Fabricant LE, Jacoby RJ, Morrison KL, et al. (1 July 2015).
9957: 851:
research has suggested that overvalued ideas are more stable for those with more extreme OVIS scores.
15518: 15308: 14993: 14852: 14136: 14105: 13483: 13366: 12952: 9224:
Kim KW, Lee DY (2002). "Obsessive-compulsive disorder associated with a left orbitofrontal infarct".
8895:"Multimodal voxel-based meta-analysis of white matter abnormalities in obsessive-compulsive disorder" 8237:
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1000:. More than 50% of people with OCD experience suicidal tendencies, and 15% have attempted 8: 15408: 15236: 14832: 14459: 14439: 14069: 14051: 14014: 14004: 13858: 13760: 13737: 13585: 13577: 13356: 13334: 13062: 12932: 12859: 12457:"Double Dare Host Marc Summers Crossed Paths With Broadway, and Now He's Got a Solo Show" 12364:"Royal College of Psychiatrists, Discover Psychiatry, Minds on Film Blog, Matchstick Men" 9791:
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based around the character of Felix, who shows some of the common symptoms of OCD.
1709:
These thoughts, impulses, or images are of a degree or type that lies outside the
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portrays a man with OCD who performs ritualistic behaviors that disrupt his life.
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estimated rates for obsessive-compulsive disorder per 100,000 inhabitants in 2004
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range of worries about conventional problems. A person may attempt to ignore or
1532:
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in a trio-based analysis, but no SNP reached significance when analyzed with
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treating obsessive thoughts with positive thoughts and mind-based therapy.
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People with OCD may face intrusive thoughts, such as thoughts about the
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353:(Y-BOCS) assess severity. Other disorders with similar symptoms include 15361: 15231: 15219: 15172: 15129: 15041: 15037: 14972: 14968: 14960: 14952: 14571: 14553: 14548: 14543: 14538: 14528: 14418: 14199: 13892: 13797: 13498: 13223: 13218: 13014: 11424:"A review of obsessive-compulsive disorder in children and adolescents" 10892: 9394: 8910: 8187:"A review of obsessive-compulsive disorder in children and adolescents" 7919:
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medication, a result believed to be caused by increased stimulation of
1541: 1047: 762: 730: 705:
push the event from their thoughts. In any case, their reasoning is so
615: 518:(obsessive thought subtype). Subgroups have also been distinguished by 453: 449: 441: 437: 75: 14514: 12817: 12333:"Is This 'As Good as It Gets?': Popular Media's Representation of OCD" 11156:"FDA Approves Pioneering Treatment for Obsessive- Compulsive Disorder" 10761:"Review Finds SSRIs Modestly Effective in Short-Term Treatment of OCD" 10679: 10319: 10302: 9092: 9075: 7610: 6612: 6610: 6530: 6528: 6349: 6347: 6345: 5630:"Table 3.13, DSM-IV to DSM-5 Obsessive-Compulsive Disorder Comparison" 5502: 4586: 4483: 4481: 4334: 4332: 4076: 3608: 3606: 3456: 3454: 2505:
has openly spoken about his life-long struggle with OCD, particularly
2433:
Obsessive-compulsive symptoms worsened during the early stages of the
1858:
asymptomatic; some therapists are also hesitant to use this approach.
721:, and other body-focused repetitive behavior disorders are all on the 14710: 14506: 14413: 14152: 14084: 13902: 13361: 13099: 13024: 12927: 11213: 10778:
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is also known to have OCD, among other mental health conditions.
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approved deep-brain stimulation for the treatment of OCD under a
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2706: 2654: 2553: 2437:, particularly for individuals with contamination-related OCD. 2056: 1590: 1315: 1307: 1255: 1237: 1226: 1214: 1195: 741:, even in cases where there is no clear evidence of a deficit. 738: 646: 393: 345:-inducing events such as during the postpartum period or after 57: 11049:
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3) This disturbance does not only occur during delirium.
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Individuals with OCD have also been found to be affected by
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A blister pack of sertraline under the brand name Zoloft
1794:, or are otherwise appropriate, correct, or reasonable. 1667:
have been implicated in OCD. Findings such as increased
254:, or discomfort. Some common obsessions include fear of 15087: 13829: 11700: 10484: 9955: 8624: 7547: 6453: 6038:
Turk Psikiyatri Dergisi = Turkish Journal of Psychiatry
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plagued by constant and overwhelming "temptations to
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primarily obsessional obsessive compulsive disorder
2507:
primarily obsessional obsessive–compulsive disorder
2262:. This man is described as "turning pale under his 761:and hot water can make their skin red and raw with 566:
Primarily obsessional obsessive compulsive disorder
288:
primarily obsessional obsessive–compulsive disorder
12992: 12532: 11875: 11873: 9891: 9889: 8417: 5573: 5535: 4885: 4789: 2406:decades following Meyer's creation of the method. 1772:OCD is often confused with the separate condition 1265: 810: 239:) and feels the need to perform certain routines ( 87:Feel the need to check things repeatedly, perform 14994: 14244: 11103:Bosanac P, Hamilton B, Lucak J, Castle D (2018). 10123: 9669: 8282: 8280: 8278: 8276: 6919: 5479: 4952:. unknown library. New York, G. P. Putnam's sons. 3360:"Obsessive-Compulsive Disorder in Children | CDC" 1997:National Institute for Health and Care Excellence 1653:. Furthermore, increased dopamine release in the 1637:. Further complicating things is the efficacy of 1321:A review of studies examining anti-basal ganglia 15500: 13401: 12448: 11308: 8851: 8013:"Overview - Obsessive compulsive disorder (OCD)" 6880: 6878: 5681: 5656: 4384: 3294:"Overview – Obsessive compulsive disorder (OCD)" 2477:", real name Ernst Lanzer, a notable patient of 1548:thoughts, finding increased connectivity of the 796:(nail biting), behavioral interventions such as 14949:Tooltip Selective serotonin reuptake inhibitors 12186: 11870: 11631: 11629: 11627: 11225: 11223: 9886: 9073: 8714:"The neurobiological link between OCD and ADHD" 8332: 8330: 8328: 8326: 8087:Sigra S, Hesselmark E, Bejerot S (March 2018). 7206:"Obsessive-compulsive symptoms with olanzapine" 2724:or the binding to its receptors. These include 2569: 2385:One of the first successful treatments of OCD, 14174: 11881:"The history of obsessive-compulsive disorder" 11625: 11623: 11621: 11619: 11617: 11615: 11613: 11611: 11609: 11607: 10351: 9548: 8460: 8273: 7338: 6981: 5992: 5024: 4522: 3919: 3656: 3654: 3652: 2949:"What is Obsessive-Compulsive Disorder (OCD)?" 2430:, which were shown to have less side effects. 2389:, emerged during the 1960s, when psychologist 2364:. Westphal's description went on to influence 1452:, while decreased activation was found in the 1022:Some research has demonstrated a link between 831:Some people with OCD exhibit what is known as 32:"OCD" redirects here. Not to be confused with 15073: 14909: 14230: 12960: 12569: 11329: 11302: 9912: 9308: 9306: 8761: 8759: 8757: 8718:Attention Deficit and Hyperactivity Disorders 7633: 7599:The International Journal of Eating Disorders 7407: 7103: 6956: 6875: 6036:Çetinay Aydın P, Güleç Öyekçin D (2013). "". 5133:Highlights of Changes from DSM-IV-TR to DSM-5 4945: 4852:"On the nature and treatment of scrupulosity" 4671:Journal of Autism and Developmental Disorders 4057: 3660: 1258:, or the environment for enemies. Similarly, 14505: 12682: 12395:"Happy to Be Neurotic, at Least Once a Week" 12208:"Obsessive-Compulsive Disorder in the Media" 11642:. New York City, New York: Dell Publishing. 11470: 11296:Obsessive Children: A Sociopsychiatric Study 11220: 10124:Twohig MP, Hayes SC, Masuda A (March 2006). 9759: 9757: 9376: 8365: 8323: 8232: 8230: 8178: 7916: 7154: 6913: 6834: 6657: 5675: 4849: 3460: 2565:and other body-focused repetitive behaviors. 1955:serotonin-norepinephrine reuptake inhibitors 1839:serotonin-norepinephrine reuptake inhibitors 1645:activity observed in OCD, and low levels of 475:repetitive transcranial magnetic stimulation 14282: 12324: 12205: 11976:– via Westsuffolkpsych.homestead.com. 11604: 11490:10.4103/psychiatry.IndianJPsychiatry_526_18 10938:The Cochrane Database of Systematic Reviews 10717:The Cochrane Database of Systematic Reviews 9361: 8976: 8495: 8129: 6616: 6321: 4557: 3974:The Cochrane Database of Systematic Reviews 3896:"Medications Approved for Treatment of OCD" 3649: 3480:10.4103/psychiatry.IndianJPsychiatry_526_18 2942: 2940: 2938: 2936: 2934: 2932: 2801:. Unsourced material may be challenged and 2691:has been suggested as a treatment for OCD. 15080: 15066: 14916: 14902: 14863:Relationship obsessive–compulsive disorder 14237: 14223: 13864:Other specified feeding or eating disorder 13131: 12967: 12953: 12424:Anxiety Disorders Association of America. 11719:Jenike MA, Baer L, Minichiello WE (1986). 11714: 11712: 11701:Al-Balkhi A, Misri M, al-Hayyat M (2005). 10232:(2nd ed.). New York: Guilford Press. 9747: 9745: 9591: 9303: 9258: 9022: 8754: 8080: 7018: 6499:Journal of Child Psychology and Psychiatry 6496: 5418:The British Journal of Clinical Psychology 5206:Psychiatric Nursing: Contemporary Practice 4609:Obsessive-Compulsive and Related Disorders 4380: 4378: 4053: 4051: 3821:National Institute of Mental Health (NIMH) 3365:Centers for Disease Control and Prevention 3214: 3212: 3210: 3114: 3112: 3110: 3108: 3106: 3104: 2930: 2928: 2926: 2924: 2922: 2920: 2918: 2916: 2914: 2912: 2360:) used in the first conceptions of OCD by 1829:One specific CBT technique used is called 282:, ordering, repeating, avoiding triggers, 56: 14923: 14838:Obsessive–compulsive personality disorder 12718: 12700: 12659: 12612: 12271: 12164:. Amanpour and Company. 26 September 2022 12096:"George Ezra opens up about OCD struggle" 11932: 11922: 11568: 11498: 11488: 11447: 11283:. Washington: American Psychiatric Press. 11255: 11130: 11120: 10805: 10795: 10736: 10687: 10638: 10628: 10553: 10461: 10412: 10318: 10093: 10028: 9869: 9859: 9818: 9808: 9754: 9617: 9424: 9422: 9402: 9338: 9286: 9276: 9150: 9140: 9091: 9074:Nakao T, Okada K, Kanba S (August 2014). 9050: 9040: 8918: 8869: 8737: 8601: 8560: 8466: 8443: 8411: 8227: 8210: 8161: 8104: 7985: 7841: 7795: 7573: 7478: 7364: 7272: 7262: 7221: 7180: 7131: 7121: 7080: 7070: 6858: 6817: 6807: 6766: 6756: 6634: 6430: 6381: 6371: 6360:Journal of Central Nervous System Disease 6298: 6288: 6203: 6193: 5699: 5652: 5650: 5501: 5366: 5309: 5107: 5054: 4961: 4959: 4870: 4816: 4746: 4690: 4585: 4575: 4461: 4410: 4312: 4220: 4210: 4169: 4085: 4075: 4031: 3945: 3900:Beyond OCD: OCD Information and Resources 3756: 3586: 3537: 3488: 3478: 3413: 3403: 3190: 3180: 3056: 3054: 2821:Learn how and when to remove this message 1988:, a medication belonging to the class of 1921:(BFRB), behavioral interventions such as 1774:obsessive–compulsive personality disorder 1767: 1440:, while hypoactivity was observed in the 1036:obsessive–compulsive personality disorder 917:Digital media use and mental health § OCD 375:obsessive–compulsive personality disorder 306:, helping differentiate between the two. 300:obsessive-compulsive personality disorder 298:. In contrast, thoughts and behaviors in 180:obsessive–compulsive personality disorder 34:Obsessive–compulsive personality disorder 15294:Attention deficit hyperactivity disorder 14127:Disorganized (hebephrenic) schizophrenia 13723:Depersonalization-derealization disorder 12756:) is being considered for deletion. See 12640:Pharmacology, Biochemistry, and Behavior 12277: 12254:"Don't Be Afraid of the Word "Disorder"" 12036: 12005: 11727: 11665: 11595: 11278: 11010: 10228:Hayes SC, Strosahl K, Wilson KG (2012). 9707: 9018: 9016: 8979:The Psychiatric Clinics of North America 8852:Radua J, Mataix-Cols D (November 2009). 8590:Journal of Psychiatry & Neuroscience 8418:Maia TV, Cooney RE, Peterson BS (2008). 8339:European Journal of Paediatric Neurology 5879: 5768: 4965: 4707: 4558:Kenyon KM, Eaton WO (16 November 2015). 4525:The Psychiatric Clinics of North America 3926:The Psychiatric Clinics of North America 3920:Pittenger C, Bloch MH (September 2014). 3867:"What Is Obsessive-Compulsive Disorder?" 3332:"What Is Obsessive-Compulsive Disorder?" 3221:The Psychiatric Clinics of North America 3158: 3156: 3154: 3152: 3150: 3023: 3021: 3019: 3017: 3015: 3013: 3011: 3009: 3007: 3005: 3003: 3001: 2999: 2997: 2552: 2512:World renowned Swedish climate activist 2137: 1940: 1820: 1359: 1351:Biology of obsessive–compulsive disorder 951: 854: 837:exposure and response prevention therapy 692: 569: 540:attention–deficit/hyperactivity disorder 14516:Selective serotonin reuptake inhibitors 12627: 12578:Expert Opinion on Investigational Drugs 12392: 12135:"James Spader: The Strangest Man on TV" 12132: 12057: 11733: 11709: 11661: 11659: 11548:. Oxford University Press. p. 19. 11421: 11083: 9742: 9519: 9517: 9515: 8371: 8184: 8007: 8005: 7500: 7498: 5814:"Over-valuedideas: aconceptualanalysis" 5608: 5272:"Obsessive-Compulsive Disorder, (2005)" 4879: 4859:Pragmatic Case Studies in Psychotherapy 4375: 4048: 3207: 3101: 2995: 2993: 2991: 2989: 2987: 2985: 2983: 2981: 2979: 2977: 2909: 2457:Grace Abounding to the Chief of Sinners 1951:selective serotonin reuptake inhibitors 1835:selective serotonin reuptake inhibitors 1813:are the first-line treatments for OCD. 1690:Formal diagnosis may be performed by a 903: 194:selective serotonin reuptake inhibitors 14: 15501: 14260:Dimensional Obsessive-Compulsive Scale 12506: 12330: 12206:Fennell D, Boyd M (2 September 2014). 12063: 12053:from the original on 29 December 2008. 11847: 11835:"Behavior Therapy for OCD: Its Origin" 11635: 11153: 11093:. California: Thomson Wadsworth, 2006. 9419: 9377:Aoki Y, Aoki A, Suwa H (August 2012). 9259:Wood J, Ahmari SE (17 December 2015). 9223: 8501: 8093:Neuroscience and Biobehavioral Reviews 7959: 6802:. Hindawi Psychiatry Journal: 186927. 6734: 6732: 6230:Child Psychiatry and Human Development 5647: 5018: 4956: 4599: 4597: 4385:Leckman JF, Bloch MH, King RA (2009). 4064:Neuropsychiatric Disease and Treatment 3967: 3965: 3811: 3809: 3807: 3805: 3051: 2548: 2254:an ancient Roman man who possibly had 1273:studies have shown differences in the 1111:Cause of obsessive-compulsive disorder 578:(shown is a painted interpretation of 396:scores. Treatment for OCD may involve 15424:Psychological effects of Internet use 15061: 14897: 14265:Yale–Brown Obsessive Compulsive Scale 14218: 14173: 14041: 13976: 13828: 13555: 13400: 13310: 13130: 12991: 12948: 12786: 12618: 12480: 12454: 12405:from the original on 11 December 2008 12343:from the original on 22 February 2015 12076:from the original on 22 February 2015 11986: 11798: 11768: 11523:"Obsessive-Compulsive Disorder (OCD)" 11293: 9918: 9640: 9173: 9080:Psychiatry and Clinical Neurosciences 9013: 6029: 5832: 5830: 5811: 5733: 5729: 5727: 5569: 5567: 5531: 5529: 4487: 4001: 3999: 3890: 3888: 3661:Fenske JN, Schwenk TL (August 2009). 3252: 3250: 3147: 3118: 2610:(2003) portrays a con man named Roy ( 2258:, which could be a symptom of OCD or 2059:is made in an area of the brain (the 1727:Yale–Brown Obsessive Compulsive Scale 1210:to be inversely associated with OCD. 864:, most significantly those affecting 626:, is another common obsession theme. 496:Yale–Brown Obsessive Compulsive Scale 488: 351:Yale–Brown Obsessive–Compulsive Scale 13311: 11827: 11656: 11013:British Journal of Hospital Medicine 10968: 10862:"Paroxetine prescribing information" 10830:"Sertraline prescribing information" 10655: 10604: 10570: 9848:Journal of Medical Internet Research 9797:Journal of Medical Internet Research 9772:from the original on 12 January 2017 9512: 9455:10.1001/archpsyc.1989.01810110048007 8469:British Journal of Hospital Medicine 8236: 8002: 7495: 7032:from the original on 1 November 2013 5986: 5233: 5202: 5146:from the original on 19 October 2013 4998: 4992: 4810: 4787: 4502:10.1001/archpsyc.1989.01810040041007 4301:The Journal of Reproductive Medicine 3567:Psychiatric Clinics of North America 3326: 3324: 3322: 3320: 3318: 3288: 3286: 2974: 2799:adding citations to reliable sources 2766: 2498:(2004), a film biography of Hughes. 1621:and OCD has been observed. Although 1198:was associated with OCD overall, in 337:. Risk factors include a history of 15089:Digital media use and mental health 13830:Physiological and physical behavior 12772:National Institute Of Mental Health 12361: 12187:Banfield-Nwachi M (28 April 2023). 12018:from the original on 5 January 2015 7726: 7339:Schirmbeck F, Zink M (March 2012). 6729: 6617:Geller DA, March J (January 2012). 5657:Ruiz P, Sadock B, Sadock V (2017). 5025:Williams MT, Farris SG (May 2011). 4914: 4594: 3962: 3802: 3357: 3121:The New England Journal of Medicine 2633:The Life and Slimes of Marc Summers 2623:(2002–2009), the titular character 2541:In a documentary released in 2023, 2334:, named Mrs. Davie, described by a 1511: 1126: 24: 13776:Psychogenic non-epileptic seizures 13170:Emotional and behavioral disorders 12012:American Psychological Association 11955: 11428:Dialogues in Clinical Neuroscience 11170:from the original on 10 July 2009. 10985:The American Journal of Psychiatry 10361:The American Journal of Psychiatry 9922:The American Journal of Psychiatry 9897:The Behavior Analyst Today, 4 (1), 9716:Journal of Cognitive Psychotherapy 9681:Journal of Cognitive Psychotherapy 8512:10.1016/B978-0-444-52014-2.00046-X 8191:Dialogues in Clinical Neuroscience 5827: 5724: 5682:O'Dwyer AM, Marks I (March 2000). 5564: 5526: 5397:from the original on 21 April 2009 5084:Dialogues in Clinical Neuroscience 4441:The American Journal of Psychiatry 4391:Dialogues in Clinical Neuroscience 4341:The Journal of Clinical Psychiatry 4058:Decloedt EH, Stein DJ (May 2010). 3996: 3885: 3773: 3430: 3247: 2954:U.S. National Institutes of Health 2627:fears both human contact and dirt. 2028:American Psychological Association 1575: 1160:components of OCD causation, with 25: 15535: 15451:Smartphones and pedestrian safety 15336:Narcissistic personality disorder 14999:Tooltip Tricyclic antidepressants 14649:Acceptance and commitment therapy 14310:Brain-derived neurotrophic factor 13956:Hypoactive sexual desire disorder 12760:to help reach a consensus. › 12739: 12314:"Felix Unger from The Odd Couple" 11091:Essentials of Abnormal Psychology 10842:from the original on 16 June 2015 10201: 9265:Frontiers in Systems Neuroscience 9029:Frontiers in Systems Neuroscience 8858:The British Journal of Psychiatry 8780:10.1001/archgenpsychiatry.2010.70 8639:10.1016/j.pscychresns.2004.07.001 8549:The British Journal of Psychiatry 5211:Lippincott Williams & Wilkins 4796:. 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International OCD Foundation. 6511:10.1111/j.1469-7610.2007.01875.x 3871:American Psychiatric Association 3530:10.1176/appi.neuropsych.20.4.390 3438:"What are compulsions? | OCD-UK" 2771: 2751: 2582:The play and film adaptations of 2440: 2422:developed in the 1970s, such as 2387:exposure and response prevention 2308:Sustenance of the Body and Soul, 2008:, and insufficient evidence for 1911:American Psychiatric Association 1831:exposure and response prevention 1458:cortico-striato-thalamo-cortical 1304:Group A streptococcal infections 1187:in unrelated families with OCD. 931: 915:This section is an excerpt from 629:Some people with OCD experience 426:exposure and response prevention 371:body-focused repetitive behavior 15183:Computer-mediated communication 14924: 13085:Intermittent explosive disorder 13010:Ego-dystonic sexual orientation 12793:. 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Psychotherapies derived from 13728:Dissociative identity disorder 12993:Adult personality and behavior 12368:Royal College of Psychiatrists 11801:Behaviour Research and Therapy 11668:Journal of Affective Disorders 10946:10.1002/14651858.CD008141.pub2 9962:Journal of Affective Disorders 9598:Psychiatry, Psychology and Law 9443:Archives of General Psychiatry 8768:Archives of General Psychiatry 8301:10.1016/j.psyneuen.2018.04.013 8142:Paediatrics & Child Health 7251:Indian Journal of Pharmacology 6934:10.1146/annurev.psych.49.1.377 6573:American Journal of Psychiatry 5917:Behaviour Research and Therapy 5882:Behaviour Research and Therapy 5851:10.1016/j.psychres.2017.05.001 5821:Behaviour Research and Therapy 5771:Behaviour Research and Therapy 5736:Behaviour Research and Therapy 5576:Journal of Affective Disorders 5166:Behaviour Research and Therapy 5047:10.1016/j.psychres.2010.10.019 4946:Hammond WA, Morton WJ (1879). 4888:Journal of Clinical Psychology 4490:Archives of General Psychiatry 4454:10.1176/appi.ajp.2008.08020320 4199:Journal of Affective Disorders 3982:10.1002/14651858.CD005333.pub2 3698:Journal of Affective Disorders 2687:The naturally occurring sugar 2636:(2016), a stage adaptation of 1558:ventromedial prefrontal cortex 1375:dorsolateral prefrontal cortex 1328: 682: 610:. Another common obsession is 608:inanimate objects are ensouled 302:(OCPD) are usually considered 27:Mental and behavioral disorder 13: 1: 15509:Obsessive–compulsive disorder 15282:Obsessive–compulsive disorder 14246:Obsessive–compulsive disorder 12763:Obsessive–compulsive disorder 12745: 11600:. Classics Club. p. 375. 11569:Friedrich P (29 April 2016). 11025:10.12968/hmed.2006.67.2.20466 10454:10.1016/S2215-0366(16)30280-2 10405:10.1016/S2215-0366(16)30069-4 9610:10.1080/13218719.2020.1745497 9551:Current Opinion in Psychiatry 8374:Current Opinion in Pediatrics 8239:Current Opinion in Pediatrics 7428:10.1016/S0140-6736(09)60240-3 7310:10.1016/s0924-977x(00)00096-1 6128:10.1016/j.janxdis.2014.12.016 5929:10.1016/S0005-7967(98)00191-0 5748:10.1016/S0005-7967(01)00016-X 4537:10.1016/S0193-953X(18)30205-3 2902: 2887:Obsessive–compulsive spectrum 2338:as "a good wife", was nearly 2144:disability-adjusted life year 2081:humanitarian device exemption 2037: 1936: 1801: 1742:obsessive–compulsive spectrum 1344: 1297: 1117:adverse childhood experiences 1042:is a possible feature (ADHD, 723:obsessive–compulsive spectrum 553: 214:Obsessive–compulsive disorder 51:Obsessive–compulsive disorder 18:Obsessive Compulsive Disorder 15439:Social aspects of television 15277:Generalized anxiety disorder 15137:Problematic social media use 14654:Cognitive behavioral therapy 14564:Monoamine oxidase inhibitors 14132:Pseudoneurotic schizophrenia 13669:Generalized anxiety disorder 13402:Neurological and symptomatic 13047:Sexual relationship disorder 12507:Mangan L (30 January 2019). 12224:10.1080/01639625.2013.872526 12064:Chosak A (12 October 2012). 11962:International OCD Foundation 11813:10.1016/0005-7967(66)90023-4 11748:10.1016/0010-440x(89)90052-7 11703:Masālih al-Abdān Wa-al-Anfus 11477:Indian Journal of Psychiatry 11248:10.1080/15374416.2013.804386 10546:10.1080/16506073.2012.751124 9563:10.1097/yco.0b013e32833f3b58 8823:10.1016/j.cortex.2013.01.016 8683:10.1016/j.eurpsy.2017.08.001 8386:10.1097/MOP.0b013e32831db2c4 8251:10.1097/MOP.0000000000000546 7566:10.1016/j.eatbeh.2019.05.001 7519:10.1016/j.eatbeh.2020.101386 6672:10.1016/0165-1781(95)02752-1 6585:10.1176/appi.ajp.160.11.1919 6336:10.1016/0887-6185(89)90020-0 6324:Journal of Anxiety Disorders 6116:Journal of Anxiety Disorders 6073:Nature Reviews. 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Oxford University Press. 9023:Wood J, Ahmari SE (2015). 8944:Clinical Psychology Review 8351:10.1016/j.ejpn.2018.01.011 7357:10.2174/157015912799362724 7173:10.1136/gpsych-2021-100741 6899:10.1016/j.smrv.2012.12.002 6703:Clinical Psychology Review 6636:10.1016/j.jaac.2011.09.019 6290:10.1038/s41398-023-02433-2 5359:10.1016/j.jaac.2014.09.014 5182:10.1016/j.brat.2007.11.001 4949:Neurological contributions 4817:Mash EJ, Wolfe DA (2005). 4720:Clinical Psychology Review 4632:Clinical Psychology Review 3627:10.1007/s11126-020-09769-8 3518:Journal of Neuropsychiatry 3063:Clinical Psychology Review 2755: 2501:English singer-songwriter 2349:arose as a translation of 2234: 2131: 1816: 1450:posterior cingulate cortex 1403:posterior cingulate cortex 1348: 1252:evolutionary psychologists 1250:It has been postulated by 1108: 914: 907: 686: 563: 557: 526:While OCD is considered a 31: 15344: 15262: 15155: 15095: 15012: 14934: 14853:Primarily Obsessional OCD 14818: 14756: 14727: 14695: 14688: 14681: 14641: 14620: 14598: 14582:Tricyclic antidepressants 14580: 14562: 14498: 14392: 14318: 14273: 14252: 14180: 14169: 14145: 14137:Simple-type schizophrenia 14114: 14106:Schizophreniform disorder 14083: 14062: 14058: 14037: 13990: 13972: 13941: 13918: 13872: 13839: 13835: 13824: 13746: 13713: 13661: 13604: 13595: 13576: 13572: 13551: 13517: 13484:Mild cognitive impairment 13469:Creutzfeldt–Jakob disease 13449: 13411: 13407: 13396: 13367:Major depressive disorder 13320: 13306: 13272:Psychological development 13271: 13246: 13143: 13139: 13126: 13055: 13002: 12998: 12987: 12907: 12811: 12689:Frontiers in Neuroscience 12652:10.1016/j.pbb.2011.10.007 12590:10.1517/13543784.12.6.993 11993:www.psychologistworld.com 11987:Waude A (29 March 2016). 11680:10.1016/j.jad.2015.03.003 11598:Selected Lives and Essays 11393:10.1007/s40263-013-0056-z 11350:10.1016/j.cpr.2004.08.004 11154:Barlas S (8 April 2009). 11122:10.1186/s12888-018-1771-2 10907:10.1007/s11920-017-0847-x 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3268:World Health Organization 3233:10.1016/j.psc.2014.06.004 3182:10.1186/s12888-014-0317-5 3079:10.1016/j.cpr.2015.03.002 2882:Major depressive disorder 2617:In the television series 2244:ancient Greek philosopher 2043:Electroconvulsive therapy 1990:tricyclic antidepressants 1462:anterior cingulate cortex 1419:anterior cingulate cortex 1194:found that while neither 1104: 1075:major depressive disorder 958:major depressive disorder 359:major depressive disorder 333:to be affected than both 311:anterior cingulate cortex 203: 185: 168:major depressive disorder 160: 150: 126: 118: 98: 81: 69: 64: 55: 50: 15466:Suicide and the Internet 15456:Social media and suicide 15203:Media naturalness theory 14185:Impulse-control disorder 14101:Schizoaffective disorder 14096:Brief reactive psychosis 13793:Mass psychogenic illness 13756:Body dysmorphic disorder 13535:Post-concussion syndrome 13145:Emotional and behavioral 12758:templates for discussion 12455:Gioia M (6 April 2016). 11736:Comprehensive Psychiatry 10630:10.3389/fpsyt.2020.00717 9478:Psychological Assessment 9383:Translational Psychiatry 9278:10.3389/fnsys.2015.00171 9142:10.3389/fpsyg.2015.01798 9042:10.3389/fnsys.2015.00171 8289:Psychoneuroendocrinology 7264:10.4103/0253-7613.100406 7072:10.3389/fpsyt.2011.00070 6996:10.1177/0145445505279261 6550:10.1001/jama.292.16.1969 6468:10.3810/pgm.2012.01.2528 6277:Translational Psychiatry 4171:10.1136/jnnp-2021-328738 2857:Body dysmorphic disorder 2659:Turtles All the Way Down 2646:Turtles All the Way Down 1811:psychotropic medications 1442:medial prefrontal cortex 1407:superior parietal lobule 1387:globus pallidus externus 1156:There appear to be some 994:body dysmorphic disorder 986:transformation obsession 544:autism spectrum disorder 347:streptococcal infections 15287:Social anxiety disorder 15120:Online problem gambling 15030:Atypical antipsychotics 14868:Social anxiety disorder 14736:Everything in Its Place 14664:Inference-based therapy 14600:Atypical antipsychotics 14122:Childhood schizophrenia 13474:Frontotemporal dementia 13431:High-functioning autism 13248:Intellectual disability 10617:Frontiers in Psychiatry 9129:Frontiers in Psychology 8899:Neuropsychopharmacology 7960:Bracha HS (July 2006). 7110:Frontiers in Psychiatry 7058:Frontiers in Psychiatry 5434:10.1348/014466502163769 5209:. Baltimore, Maryland: 4968:"Thinking Bad Thoughts" 3358:CDC (2 December 2020). 2413:reported that the drug 2292:technique now known as 2269:In the 7th century AD, 2069:vagus nerve stimulation 1923:habit-reversal training 1880:Inference-based therapy 1432:, ACC, and head of the 1091:social anxiety disorder 1054:; this has been termed 1046:, bodily disorders, or 974:social anxiety disorder 798:habit reversal training 434:inference based-therapy 15444:Television consumption 15399:Evolution of cognition 15324:Body image disturbance 15265:psychiatric conditions 15193:Engineering psychology 15115:Internet sex addiction 15096:Proposed or recognised 15020:Typical antipsychotics 14633:Deep brain stimulation 14464:Experiential avoidance 13639:Specific social phobia 13530:Organic brain syndrome 13372:Melancholic depression 13133:Childhood and learning 10499:10.1001/jama.2017.2200 10442:The Lancet. Psychiatry 10393:The Lancet. Psychiatry 10017:Depression and Anxiety 6887:Sleep Medicine Reviews 6411:Depression and Anxiety 6195:10.3390/ijerph15040668 5995:Psychological Medicine 5952:Neuropsychology Review 5661:(10th ed.). LWW. 5298:Depression and Anxiety 4872:10.14713/pcsp.v4i2.932 4123:10.1001/jama.2017.2200 3392:Depression and Anxiety 2664:The British TV series 2566: 2451:The Pilgrim's Progress 2409:In 1967, psychiatrist 2284:The Cloud of Unknowing 2227: 2086:In the United States, 2065:Deep brain stimulation 1946: 1913:(APA) noted a lack of 1826: 1768:Differential diagnosis 1366: 1065:OCD frequently occurs 701: 592:relationship rightness 583: 516:spatial working memory 514:(washing subtype) and 471:deep brain stimulation 466:atypical antipsychotic 424:(CBT) models, such as 416:or, in extreme cases, 414:deep brain stimulation 162:Differential diagnosis 36:. For other uses, see 15488:Texting while driving 15419:Promotion of anorexia 15404:Evolutionary mismatch 15367:Criticism of Facebook 15098:diagnostic categories 14669:Metacognitive therapy 14195:Psychomotor agitation 13985:and substance-related 13928:Postpartum depression 13808:Somatization disorder 13694:Acute stress reaction 13459:AIDS dementia complex 12043:Monitor on Psychology 10208:contextualscience.org 9906:23 March 2010 at the 7888:10.1038/sj.mp.4001951 7654:10.1038/sj.mp.4001365 6984:Behavior Modification 6456:Postgraduate Medicine 5701:10.1192/bjp.176.3.281 3615:Psychiatric Quarterly 3133:10.1056/NEJMcp1402176 2556: 2141: 2132:Further information: 1944: 1892:inferential confusion 1824: 1680:N-Acetylaspartic acid 1633:, through inhibiting 1595:serotonin transporter 1506:fractional anisotropy 1504:volume and decreased 1479:volumes in bilateral 1363: 1048:stereotyped behaviors 952:Associated conditions 855:Cognitive performance 751:stereotyped movements 699:skin-picking disorder 696: 622:of contamination and 573: 262:, the fear of acting 15357:Behavioral modernity 15352:Behavioral addiction 15178:Cognitive ergonomics 15163:Digital anthropology 15156:Disciplines involved 15147:Video game addiction 15142:Television addiction 14843:Obsessional jealousy 14300:Orbitofrontal cortex 14190:Klüver–Bucy syndrome 14020:Substance dependence 13933:Postpartum psychosis 13479:Huntington's disease 13261:Lujan–Fryns syndrome 13110:Personality disorder 12790:Obsession: A History 12278:Goldberg FR (2007). 11279:Rapoport JE (1989). 11186:25 July 2008 at the 7931:10.1002/ajmg.b.20013 7876:Molecular Psychiatry 7834:10.1002/ajmg.b.32137 7776:Molecular Psychiatry 7698:10.1002/ajmg.b.30699 7642:Molecular Psychiatry 7480:10.1093/brain/awm205 7473:(Pt 12): 3223–3236. 6373:10.4137/JCNSD.S38359 5092:Taylor & Francis 4353:10.4088/JCP.19r13085 4012:Molecular Psychiatry 3788:. pp. 166–187. 2795:improve this section 2411:Juan José López-Ibor 2347:obsessive–compulsive 2336:justice of the peace 1643:dopamine transporter 1371:orbitofrontal cortex 910:Video game addiction 904:Video game addiction 890:cognitive inhibition 697:A person exhibiting 383:obsessive–compulsive 325:. The presence of a 315:orbitofrontal cortex 38:OCD (disambiguation) 15409:Fear of missing out 14833:Illusion of control 14460:Thought suppression 14070:Delusional disorder 14015:Stimulant psychosis 14005:Physical dependence 13859:Rumination syndrome 13761:Conversion disorder 13738:Psychogenic amnesia 13588:with depressed mood 13586:Adjustment disorder 13489:Parkinson's disease 13464:Alzheimer's disease 13357:Atypical depression 13193:Social functioning 13068:Munchausen syndrome 13063:Factitious disorder 12436:on 17 December 2008 12374:on 22 February 2015 12122:. 24 February 2020. 10874:on 19 February 2015 8671:European Psychiatry 8627:Psychiatry Research 6809:10.1155/2015/186927 6660:Psychiatry Research 5839:Psychiatry Research 5031:Psychiatry Research 4980:on 15 November 2011 4823:Belmont, California 2872:Delusional disorder 2709:inhibitors such as 2549:Society and culture 2396:fear extinguishment 2340:burned at the stake 1882:(IBT) is a form of 922:In April 2018, the 826:psychotic disorders 689:Compulsive behavior 676:compulsive hoarding 512:pattern recognition 412:procedures such as 15105:Computer addiction 14858:Questionable cause 14765:As Good as It Gets 14089:schizophrenia-like 13733:Dissociative fugue 13182:Movement disorders 12908:External resources 12399:The New York Times 11422:Boileau B (2011). 9395:10.1038/tp.2012.78 8911:10.1038/npp.2014.5 8185:Boileau B (2011). 8154:10.1093/pch/pxy145 8019:. 16 February 2021 7788:10.1038/mp.2012.85 7161:General Psychiatry 6796:Psychiatry Journal 4900:10.1002/jclp.20404 4577:10.1037/arc0000022 4251:. 15 February 2023 4024:10.1038/mp.2009.50 3303:. 16 February 2021 2862:Compulsive hoarder 2697:agonists, such as 2594:As Good as It Gets 2567: 2300:Abu Zayd Al-Balkhi 2294:emotional flooding 2228: 1947: 1915:controlled studies 1827: 1587:Serotonin receptor 1498:anterior cingulate 1489:anterior cingulate 1367: 1225:, and two SNPs in 1123:-inducing events. 878:executive function 862:cognitive deficits 759:antibacterial soap 702: 664:sexual orientation 584: 532:neuropsychological 489:Signs and symptoms 268:sexual orientation 233:intrusive thoughts 166:Anxiety disorder, 15514:Anxiety disorders 15496: 15495: 15168:Digital sociology 15055: 15054: 14928:pharmacotherapies 14891: 14890: 14878:Tourette syndrome 14814: 14813: 14752: 14751: 14677: 14676: 14616: 14615: 14388: 14387: 14212: 14211: 14208: 14207: 14165: 14164: 14161: 14160: 14033: 14032: 13968: 13967: 13964: 13963: 13820: 13819: 13816: 13815: 13709: 13708: 13547: 13546: 13543: 13542: 13504:Vascular dementia 13426:Asperger syndrome 13392: 13391: 13302: 13301: 13298: 13297: 13236:Tourette syndrome 13122: 13121: 13118: 13117: 12942: 12941: 12800:978-0-226-13782-7 12787:Davis LJ (2008). 12119:Independent.co.uk 12102:. 31 August 2020. 11863:978-0-440-50847-2 11848:Osborn I (1999). 11785:978-0-393-00143-3 11649:978-0-440-50847-2 11636:Osborn I (1998). 11596:Plutarch (1951). 11582:978-1-137-42733-5 11555:978-0-19-005869-2 11311:Pediatric Nursing 11294:Adams PL (1973). 11160:Psychiatric Times 10767:on 13 April 2013. 10680:10.1002/wps.20881 10493:(13): 1358–1367. 10368:(7 Suppl): 5–53. 10320:10.1159/000524425 10239:978-1-60918-962-4 9449:(11): 1006–1011. 9210:978-0-12-374634-4 9185:978-0-7817-2837-9 9174:Davis KL (2002). 9093:10.1111/pcn.12195 8521:978-0-444-52014-2 7611:10.1002/eat.23196 7422:(9688): 491–499. 7395:. 2 February 2022 6579:(11): 1919–1928. 6544:(16): 1969–1976. 5668:978-1-4511-0047-1 5353:(12): 1308–1316. 5220:978-0-397-55178-1 4836:978-1-305-10542-3 4827:Thomson Wadsworth 4803:978-0-525-94562-8 4448:(12): 1532–1542. 4164:(11): 1166–1173. 4117:(13): 1358–1367. 4077:10.2147/NDT.S3149 3795:978-0-415-32382-6 3044:978-0-89042-555-8 2831: 2830: 2823: 2630:The one-man show 2435:COVID-19 pandemic 2354:Zwangsvorstellung 2345:The English term 2142:Age-standardized 2032:dextroamphetamine 1929:are recommended. 1884:cognitive therapy 1665:neurotransmission 1660:Abnormalities in 1655:nucleus accumbens 1631:prefrontal cortex 1581:hyperactivity of 1570:nucleus accumbens 1481:lenticular nuclei 1466:prefrontal cortex 1192:systematic review 1183:transporter gene 1017:sleep disturbance 982:Tourette syndrome 631:sexual obsessions 620:pathological fear 560:Intrusive thought 266:, the sufferer's 258:, obsession with 211: 210: 152:Diagnostic method 45:Medical condition 16:(Redirected from 15531: 15519:Magical thinking 15319:Anorexia nervosa 15304:Bipolar disorder 15272:Anxiety disorder 15082: 15075: 15068: 15059: 15058: 15000: 14996: 14985: 14981: 14950: 14946: 14927: 14918: 14911: 14904: 14895: 14894: 14693: 14692: 14686: 14685: 14512: 14511: 14503: 14502: 14305:Cingulate cortex 14280: 14279: 14239: 14232: 14225: 14216: 14215: 14171: 14170: 14060: 14059: 14039: 14038: 13974: 13973: 13849:Anorexia nervosa 13837: 13836: 13826: 13825: 13803:Psychogenic pain 13771:Globus pharyngis 13619:Childhood phobia 13602: 13601: 13574: 13573: 13553: 13552: 13409: 13408: 13398: 13397: 13308: 13307: 13207:Selective mutism 13158:Conduct disorder 13141: 13140: 13128: 13127: 13105:Trichotillomania 13080:Gender dysphoria 13075:Fear of intimacy 13032:Sexual anhedonia 13000: 12999: 12989: 12988: 12976:Mental disorders 12969: 12962: 12955: 12946: 12945: 12809: 12808: 12804: 12733: 12732: 12722: 12704: 12680: 12674: 12673: 12663: 12631: 12625: 12624: 12616: 12610: 12609: 12573: 12567: 12566: 12530: 12524: 12523: 12521: 12519: 12504: 12498: 12497: 12495: 12493: 12478: 12472: 12471: 12469: 12467: 12452: 12446: 12445: 12443: 12441: 12432:. Archived from 12421: 12415: 12414: 12412: 12410: 12390: 12384: 12383: 12381: 12379: 12370:. Archived from 12359: 12353: 12352: 12350: 12348: 12328: 12322: 12321: 12310: 12304: 12303: 12301: 12299: 12293: 12286: 12275: 12269: 12268: 12266: 12264: 12250: 12244: 12243: 12212:Deviant Behavior 12203: 12197: 12196: 12184: 12178: 12177: 12171: 12169: 12158: 12152: 12151: 12149: 12147: 12130: 12124: 12123: 12110: 12104: 12103: 12092: 12086: 12085: 12083: 12081: 12061: 12055: 12054: 12034: 12028: 12027: 12025: 12023: 12003: 11997: 11996: 11984: 11978: 11977: 11975: 11973: 11964:. Archived from 11953: 11947: 11946: 11936: 11926: 11902: 11896: 11895: 11893: 11891: 11877: 11868: 11867: 11845: 11839: 11838: 11831: 11825: 11824: 11796: 11790: 11789: 11766: 11760: 11759: 11731: 11725: 11724: 11716: 11707: 11706: 11698: 11692: 11691: 11663: 11654: 11653: 11633: 11602: 11601: 11593: 11587: 11586: 11566: 11560: 11559: 11541: 11535: 11534: 11532: 11530: 11519: 11513: 11512: 11502: 11492: 11483:(7): S114–S118. 11468: 11462: 11461: 11451: 11419: 11413: 11412: 11376: 11370: 11369: 11344:(8): 1011–1030. 11333: 11327: 11326: 11306: 11300: 11299: 11291: 11285: 11284: 11276: 11270: 11269: 11259: 11227: 11218: 11217: 11214:10.1037/h0100155 11197: 11191: 11178: 11172: 11171: 11151: 11145: 11144: 11134: 11124: 11100: 11094: 11087: 11081: 11080: 11043: 11037: 11036: 11008: 11002: 11001: 10981: 10972: 10966: 10965: 10940:(12): CD008141. 10933: 10927: 10926: 10890: 10884: 10883: 10881: 10879: 10873: 10867:. Archived from 10866: 10858: 10852: 10851: 10849: 10847: 10841: 10834: 10826: 10820: 10819: 10809: 10799: 10790:(8): 1173–1191. 10775: 10769: 10768: 10763:. Archived from 10757: 10751: 10750: 10740: 10708: 10702: 10701: 10691: 10668:World Psychiatry 10659: 10653: 10652: 10642: 10632: 10608: 10602: 10601: 10574: 10568: 10567: 10557: 10525: 10519: 10518: 10482: 10476: 10475: 10465: 10433: 10427: 10426: 10416: 10384: 10378: 10377: 10355: 10349: 10348: 10322: 10298: 10292: 10289: 10283: 10280: 10274: 10270: 10264: 10261: 10252: 10251: 10225: 10219: 10218: 10216: 10214: 10199: 10193: 10192: 10160: 10154: 10153: 10130:Behavior Therapy 10121: 10115: 10114: 10112: 10110: 10097: 10065: 10059: 10058: 10032: 10030:10.1002/da.23000 10008: 10002: 10001: 9953: 9947: 9946: 9929:(8): 1204–1211. 9916: 9910: 9893: 9884: 9883: 9873: 9863: 9839: 9833: 9832: 9822: 9812: 9788: 9782: 9781: 9779: 9777: 9761: 9752: 9749: 9740: 9739: 9711: 9705: 9704: 9676: 9667: 9666: 9638: 9632: 9631: 9621: 9589: 9583: 9582: 9546: 9540: 9539: 9537: 9535: 9529:Cleveland Clinic 9521: 9510: 9509: 9473: 9467: 9466: 9438: 9432: 9426: 9417: 9416: 9406: 9374: 9368: 9367: 9359: 9353: 9352: 9342: 9310: 9301: 9300: 9290: 9280: 9256: 9250: 9249: 9221: 9215: 9214: 9196: 9190: 9189: 9171: 9165: 9164: 9154: 9144: 9120: 9114: 9113: 9095: 9071: 9065: 9064: 9054: 9044: 9020: 9011: 9010: 8974: 8968: 8967: 8939: 8933: 8932: 8922: 8905:(7): 1547–1557. 8890: 8884: 8883: 8873: 8849: 8843: 8842: 8806: 8800: 8799: 8763: 8752: 8751: 8741: 8709: 8703: 8702: 8665: 8659: 8658: 8622: 8616: 8615: 8605: 8581: 8575: 8574: 8564: 8540: 8534: 8533: 8499: 8493: 8492: 8464: 8458: 8457: 8447: 8430:(4): 1251–1283. 8415: 8409: 8408: 8369: 8363: 8362: 8334: 8321: 8320: 8284: 8271: 8270: 8234: 8225: 8224: 8214: 8182: 8176: 8175: 8165: 8133: 8127: 8126: 8108: 8084: 8078: 8077: 8075: 8073: 8063: 8054: 8053: 8051: 8049: 8035: 8029: 8028: 8026: 8024: 8009: 8000: 7999: 7989: 7957: 7951: 7950: 7914: 7908: 7907: 7870: 7864: 7863: 7845: 7816: 7810: 7809: 7799: 7767: 7761: 7760: 7724: 7718: 7717: 7680: 7674: 7673: 7637: 7631: 7630: 7594: 7588: 7587: 7577: 7554:Eating Behaviors 7545: 7539: 7538: 7507:Eating Behaviors 7502: 7493: 7492: 7482: 7454: 7448: 7447: 7411: 7405: 7404: 7402: 7400: 7385: 7379: 7378: 7368: 7336: 7330: 7329: 7293: 7287: 7286: 7276: 7266: 7242: 7236: 7235: 7225: 7201: 7195: 7194: 7184: 7152: 7146: 7145: 7135: 7125: 7101: 7095: 7094: 7084: 7074: 7048: 7042: 7041: 7039: 7037: 7022: 7016: 7015: 6979: 6973: 6960: 6954: 6953: 6917: 6911: 6910: 6882: 6873: 6872: 6862: 6847:World Psychiatry 6838: 6832: 6831: 6821: 6811: 6787: 6781: 6780: 6770: 6760: 6736: 6727: 6726: 6698: 6692: 6691: 6655: 6649: 6648: 6638: 6614: 6605: 6604: 6568: 6562: 6561: 6532: 6523: 6522: 6494: 6488: 6487: 6451: 6445: 6444: 6434: 6423:10.1002/da.22389 6402: 6396: 6395: 6385: 6375: 6351: 6340: 6339: 6319: 6313: 6312: 6302: 6292: 6268: 6262: 6261: 6224: 6218: 6217: 6207: 6197: 6188:(4). MDPI: 668. 6173: 6167: 6166: 6146: 6140: 6139: 6111: 6105: 6104: 6068: 6062: 6061: 6033: 6027: 6026: 6001:(6): 1121–1130. 5990: 5984: 5983: 5947: 5941: 5940: 5912: 5906: 5905: 5877: 5871: 5870: 5834: 5825: 5824: 5818: 5812:Veale D (2002). 5809: 5803: 5802: 5766: 5760: 5759: 5731: 5722: 5721: 5703: 5679: 5673: 5672: 5654: 5645: 5644: 5642: 5640: 5625: 5619: 5618: 5606: 5600: 5599: 5571: 5562: 5561: 5550:10.1037/h0100282 5533: 5524: 5523: 5505: 5477: 5471: 5470: 5468: 5466: 5452: 5446: 5445: 5413: 5407: 5406: 5404: 5402: 5387: 5381: 5380: 5370: 5338: 5332: 5331: 5313: 5311:10.1002/da.20304 5289: 5283: 5282: 5280: 5278: 5268: 5262: 5261: 5231: 5225: 5224: 5203:Boyd MA (2007). 5200: 5194: 5193: 5161: 5155: 5154: 5153: 5151: 5145: 5138: 5128: 5122: 5121: 5111: 5075: 5069: 5068: 5058: 5022: 5016: 5015: 5013: 5011: 4996: 4990: 4989: 4987: 4985: 4979: 4972: 4966:Osgood-Hynes D. 4963: 4954: 4953: 4943: 4937: 4936: 4934: 4932: 4926:Cleveland Clinic 4918: 4912: 4911: 4883: 4877: 4876: 4874: 4856: 4847: 4841: 4840: 4821:(3rd ed.). 4814: 4808: 4807: 4795: 4785: 4779: 4778: 4750: 4744: 4743: 4711: 4705: 4704: 4694: 4662: 4656: 4655: 4627: 4621: 4620: 4618: 4616: 4601: 4592: 4591: 4589: 4579: 4555: 4549: 4548: 4520: 4514: 4513: 4485: 4476: 4475: 4465: 4431: 4425: 4424: 4414: 4382: 4373: 4372: 4336: 4327: 4326: 4316: 4292: 4286: 4285: 4283: 4281: 4267: 4261: 4260: 4258: 4256: 4241: 4235: 4234: 4224: 4214: 4190: 4184: 4183: 4173: 4149: 4143: 4142: 4106: 4100: 4099: 4089: 4079: 4055: 4046: 4045: 4035: 4003: 3994: 3993: 3969: 3960: 3959: 3949: 3917: 3911: 3910: 3908: 3906: 3892: 3883: 3882: 3880: 3878: 3863: 3857: 3856: 3854: 3852: 3838: 3832: 3831: 3829: 3827: 3813: 3800: 3799: 3777: 3771: 3770: 3760: 3728: 3722: 3721: 3693: 3687: 3686: 3658: 3647: 3646: 3610: 3601: 3600: 3590: 3558: 3552: 3551: 3541: 3509: 3503: 3502: 3492: 3482: 3473:(7): S114–S118. 3458: 3449: 3448: 3446: 3444: 3434: 3428: 3427: 3417: 3407: 3405:10.1002/da.20820 3383: 3377: 3376: 3374: 3372: 3355: 3349: 3348: 3346: 3344: 3328: 3313: 3312: 3310: 3308: 3290: 3281: 3280: 3278: 3276: 3263: 3254: 3245: 3244: 3216: 3205: 3204: 3194: 3184: 3160: 3145: 3144: 3116: 3099: 3098: 3058: 3049: 3048: 3025: 2972: 2971: 2969: 2967: 2944: 2897:Trichotillomania 2852:Bipolar disorder 2847:Anxiety Disorder 2826: 2819: 2815: 2812: 2806: 2775: 2767: 2738:N-acetylcysteine 2563:trichotillomania 2264:crown of flowers 2223: 2217: 2211: 2205: 2199: 2193: 2187: 2181: 2175: 2169: 2163: 2157: 2151: 2061:cingulate cortex 1974: 1750:trichotillomania 1554:ventral striatum 1512:Cognitive models 1500:gyri. Increased 1470:bipolar disorder 1413:and head of the 1381:, left superior 1339:childhood trauma 1288:neurotransmitter 1166:matched controls 1127:Drug-induced OCD 1071:bipolar disorder 998:trichotillomania 970:anorexia nervosa 962:bipolar disorder 888:, and motor and 882:processing speed 845:idealized values 833:overvalued ideas 788:(hair pulling), 786:trichotillomania 770:rationalizations 530:disorder from a 363:eating disorders 172:eating disorders 145:childhood trauma 109:anxiety disorder 60: 48: 47: 21: 15539: 15538: 15534: 15533: 15532: 15530: 15529: 15528: 15499: 15498: 15497: 15492: 15340: 15314:Eating disorder 15264: 15258: 15208:Neuroergonomics 15188:Cyberpsychology 15151: 15097: 15091: 15086: 15056: 15051: 15008: 14998: 14983: 14948: 14936:Antidepressants 14930: 14922: 14892: 14887: 14828:Guilt (emotion) 14810: 14748: 14723: 14682:Popular culture 14673: 14637: 14612: 14594: 14576: 14558: 14494: 14384: 14375: 14367: 14359: 14346: 14338: 14329: 14314: 14269: 14248: 14243: 14213: 14204: 14176: 14157: 14141: 14110: 14088: 14079: 14054: 14029: 13986: 13983:substance abuse 13960: 13937: 13914: 13868: 13854:Bulimia nervosa 13831: 13812: 13788:Hypochondriasis 13783:False pregnancy 13766:Ganser syndrome 13748:Somatic symptom 13742: 13705: 13657: 13646:Specific phobia 13591: 13568: 13539: 13513: 13445: 13441:Savant syndrome 13413:Autism spectrum 13403: 13388: 13316: 13294: 13273: 13267: 13242: 13135: 13114: 13090:Dermatillomania 13051: 13037:Sexual anorexia 12994: 12983: 12973: 12943: 12938: 12937: 12903: 12902: 12820: 12801: 12761: 12742: 12737: 12736: 12681: 12677: 12632: 12628: 12617: 12613: 12584:(6): 993–1001. 12574: 12570: 12531: 12527: 12517: 12515: 12505: 12501: 12491: 12489: 12479: 12475: 12465: 12463: 12453: 12449: 12439: 12437: 12422: 12418: 12408: 12406: 12391: 12387: 12377: 12375: 12360: 12356: 12346: 12344: 12329: 12325: 12312: 12311: 12307: 12297: 12295: 12291: 12284: 12276: 12272: 12262: 12260: 12252: 12251: 12247: 12204: 12200: 12185: 12181: 12167: 12165: 12160: 12159: 12155: 12145: 12143: 12131: 12127: 12112: 12111: 12107: 12094: 12093: 12089: 12079: 12077: 12062: 12058: 12035: 12031: 12021: 12019: 12004: 12000: 11985: 11981: 11971: 11969: 11968:on 18 June 2005 11954: 11950: 11903: 11899: 11889: 11887: 11879: 11878: 11871: 11864: 11854:Dell Publishing 11846: 11842: 11833: 11832: 11828: 11797: 11793: 11786: 11767: 11763: 11732: 11728: 11717: 11710: 11699: 11695: 11664: 11657: 11650: 11634: 11605: 11594: 11590: 11583: 11567: 11563: 11556: 11542: 11538: 11528: 11526: 11521: 11520: 11516: 11469: 11465: 11420: 11416: 11377: 11373: 11334: 11330: 11307: 11303: 11292: 11288: 11277: 11273: 11228: 11221: 11198: 11194: 11188:Wayback Machine 11179: 11175: 11152: 11148: 11101: 11097: 11088: 11084: 11055:(10): 947–960. 11044: 11040: 11009: 11005: 10979: 10973: 10969: 10934: 10930: 10891: 10887: 10877: 10875: 10871: 10864: 10860: 10859: 10855: 10845: 10843: 10839: 10832: 10828: 10827: 10823: 10776: 10772: 10759: 10758: 10754: 10723:(3): CD007954. 10709: 10705: 10660: 10656: 10609: 10605: 10576: 10575: 10571: 10526: 10522: 10483: 10479: 10434: 10430: 10385: 10381: 10356: 10352: 10299: 10295: 10290: 10286: 10281: 10277: 10271: 10267: 10262: 10255: 10240: 10226: 10222: 10212: 10210: 10200: 10196: 10161: 10157: 10122: 10118: 10108: 10106: 10066: 10062: 10009: 10005: 9954: 9950: 9917: 9913: 9908:Wayback Machine 9894: 9887: 9840: 9836: 9789: 9785: 9775: 9773: 9762: 9755: 9750: 9743: 9712: 9708: 9677: 9670: 9639: 9635: 9590: 9586: 9547: 9543: 9533: 9531: 9523: 9522: 9513: 9474: 9470: 9439: 9435: 9427: 9420: 9375: 9371: 9360: 9356: 9311: 9304: 9257: 9253: 9222: 9218: 9211: 9197: 9193: 9186: 9172: 9168: 9121: 9117: 9072: 9068: 9021: 9014: 8975: 8971: 8940: 8936: 8891: 8887: 8850: 8846: 8807: 8803: 8764: 8755: 8710: 8706: 8666: 8662: 8623: 8619: 8582: 8578: 8541: 8537: 8522: 8500: 8496: 8465: 8461: 8416: 8412: 8370: 8366: 8335: 8324: 8285: 8274: 8235: 8228: 8183: 8179: 8134: 8130: 8085: 8081: 8071: 8069: 8065: 8064: 8057: 8047: 8045: 8037: 8036: 8032: 8022: 8020: 8011: 8010: 8003: 7958: 7954: 7915: 7911: 7871: 7867: 7817: 7813: 7768: 7764: 7725: 7721: 7681: 7677: 7648:(11): 933–936. 7638: 7634: 7595: 7591: 7546: 7542: 7503: 7496: 7455: 7451: 7412: 7408: 7398: 7396: 7387: 7386: 7382: 7337: 7333: 7294: 7290: 7243: 7239: 7202: 7198: 7153: 7149: 7102: 7098: 7049: 7045: 7035: 7033: 7024: 7023: 7019: 6980: 6976: 6970:Wayback Machine 6961: 6957: 6918: 6914: 6883: 6876: 6839: 6835: 6788: 6784: 6737: 6730: 6699: 6695: 6656: 6652: 6615: 6608: 6569: 6565: 6533: 6526: 6495: 6491: 6452: 6448: 6403: 6399: 6352: 6343: 6320: 6316: 6269: 6265: 6225: 6221: 6174: 6170: 6147: 6143: 6112: 6108: 6085:10.1038/nrn3746 6069: 6065: 6034: 6030: 5991: 5987: 5948: 5944: 5913: 5909: 5878: 5874: 5835: 5828: 5816: 5810: 5806: 5767: 5763: 5732: 5725: 5680: 5676: 5669: 5655: 5648: 5638: 5636: 5626: 5622: 5607: 5603: 5572: 5565: 5534: 5527: 5478: 5474: 5464: 5462: 5454: 5453: 5449: 5426:Wiley-Blackwell 5414: 5410: 5400: 5398: 5389: 5388: 5384: 5339: 5335: 5290: 5286: 5276: 5274: 5270: 5269: 5265: 5232: 5228: 5221: 5201: 5197: 5162: 5158: 5149: 5147: 5143: 5136: 5130: 5129: 5125: 5076: 5072: 5023: 5019: 5009: 5007: 4997: 4993: 4983: 4981: 4977: 4970: 4964: 4957: 4944: 4940: 4930: 4928: 4920: 4919: 4915: 4884: 4880: 4854: 4848: 4844: 4837: 4829:. p. 197. 4815: 4811: 4804: 4788:Baer L (2001). 4786: 4782: 4751: 4747: 4712: 4708: 4663: 4659: 4628: 4624: 4614: 4612: 4603: 4602: 4595: 4556: 4552: 4521: 4517: 4486: 4479: 4432: 4428: 4383: 4376: 4337: 4330: 4307:(3–4): 115–22. 4293: 4289: 4279: 4277: 4269: 4268: 4264: 4254: 4252: 4243: 4242: 4238: 4191: 4187: 4150: 4146: 4107: 4103: 4056: 4049: 4004: 3997: 3976:(2): CD005333. 3970: 3963: 3918: 3914: 3904: 3902: 3894: 3893: 3886: 3876: 3874: 3865: 3864: 3860: 3850: 3848: 3846:medlineplus.gov 3840: 3839: 3835: 3825: 3823: 3815: 3814: 3803: 3796: 3778: 3774: 3729: 3725: 3694: 3690: 3659: 3650: 3611: 3604: 3559: 3555: 3510: 3506: 3459: 3452: 3442: 3440: 3436: 3435: 3431: 3384: 3380: 3370: 3368: 3356: 3352: 3342: 3340: 3330: 3329: 3316: 3306: 3304: 3292: 3291: 3284: 3274: 3272: 3261: 3255: 3248: 3217: 3208: 3161: 3148: 3117: 3102: 3059: 3052: 3045: 3027: 3026: 2975: 2965: 2963: 2945: 2910: 2905: 2877:Hypochondriasis 2843: 2827: 2816: 2810: 2807: 2792: 2776: 2765: 2760: 2754: 2685: 2572: 2551: 2519:American actor 2443: 2404:Stanley Rachman 2398:in animals via 2237: 2226: 2225: 2221: 2219: 2218: 112.5–120 2215: 2213: 2212: 105–112.5 2209: 2207: 2203: 2201: 2197: 2195: 2191: 2189: 2185: 2183: 2179: 2177: 2173: 2171: 2167: 2165: 2161: 2159: 2155: 2153: 2149: 2136: 2130: 2117:Quality of life 2114: 2101: 2040: 2030:suggested that 1968: 1939: 1899:Cochrane review 1819: 1804: 1776:(OCPD). OCD is 1770: 1688: 1649:binding in the 1625:, which act by 1578: 1576:Neurobiological 1514: 1415:caudate nucleus 1379:premotor cortex 1377:(dlPFC), right 1358: 1353: 1347: 1331: 1300: 1268: 1162:identical twins 1154: 1129: 1113: 1107: 1087:specific phobia 1056:tic-related OCD 990:dermatillomania 978:bulimia nervosa 954: 934: 929: 928: 920: 912: 906: 857: 813: 784:(BFRB) such as 727:memory distrust 691: 685: 668:sexual identity 568: 562: 556: 491: 406:antidepressants 402:pharmacotherapy 387:perfectionistic 335:fraternal twins 331:identical twins 122:Before 35 years 46: 41: 28: 23: 22: 15: 12: 11: 5: 15537: 15527: 15526: 15521: 15516: 15511: 15494: 15493: 15491: 15490: 15485: 15480: 15479: 15478: 15468: 15463: 15458: 15453: 15448: 15447: 15446: 15441: 15436: 15434:Binge-watching 15426: 15421: 15416: 15411: 15406: 15401: 15396: 15394:Digital zombie 15391: 15386: 15384:Cyberpathology 15381: 15376: 15375: 15374: 15364: 15359: 15354: 15348: 15346: 15345:Related topics 15342: 15341: 15339: 15338: 15333: 15328: 15327: 15326: 15321: 15311: 15306: 15301: 15296: 15291: 15290: 15289: 15284: 15279: 15268: 15266: 15260: 15259: 15257: 15256: 15255: 15254: 15249: 15244: 15239: 15229: 15228: 15227: 15217: 15212: 15211: 15210: 15205: 15200: 15195: 15190: 15185: 15180: 15170: 15165: 15159: 15157: 15153: 15152: 15150: 15149: 15144: 15139: 15134: 15133: 15132: 15122: 15117: 15112: 15107: 15101: 15099: 15093: 15092: 15085: 15084: 15077: 15070: 15062: 15053: 15052: 15050: 15049: 15027: 15016: 15014: 15010: 15009: 15007: 15006: 14991: 14976: 14940: 14938: 14932: 14931: 14921: 14920: 14913: 14906: 14898: 14889: 14888: 14886: 14885: 14880: 14875: 14870: 14865: 14860: 14855: 14850: 14845: 14840: 14835: 14830: 14824: 14822: 14816: 14815: 14812: 14811: 14809: 14808: 14801: 14794: 14787: 14782: 14779:Matchstick Men 14775: 14768: 14760: 14758: 14754: 14753: 14750: 14749: 14747: 14746: 14739: 14731: 14729: 14725: 14724: 14722: 14721: 14714: 14707: 14704:Matchstick Men 14699: 14697: 14690: 14683: 14679: 14678: 14675: 14674: 14672: 14671: 14666: 14661: 14651: 14645: 14643: 14639: 14638: 14636: 14635: 14630: 14624: 14622: 14618: 14617: 14614: 14613: 14611: 14610: 14604: 14602: 14596: 14595: 14593: 14592: 14586: 14584: 14578: 14577: 14575: 14574: 14568: 14566: 14560: 14559: 14557: 14556: 14551: 14546: 14541: 14536: 14531: 14526: 14520: 14518: 14509: 14500: 14496: 14495: 14493: 14492: 14486: 14481: 14476: 14467: 14457: 14451: 14446: 14437: 14431: 14426: 14421: 14416: 14411: 14406: 14396: 14394: 14390: 14389: 14386: 14385: 14383: 14382: 14377: 14373: 14369: 14365: 14361: 14357: 14353: 14348: 14344: 14340: 14336: 14332: 14327: 14322: 14320: 14316: 14315: 14313: 14312: 14307: 14302: 14297: 14286: 14284: 14277: 14271: 14270: 14268: 14267: 14262: 14256: 14254: 14250: 14249: 14242: 14241: 14234: 14227: 14219: 14210: 14209: 14206: 14205: 14203: 14202: 14197: 14192: 14187: 14181: 14178: 14177: 14167: 14166: 14163: 14162: 14159: 14158: 14156: 14155: 14149: 14147: 14143: 14142: 14140: 14139: 14134: 14129: 14124: 14118: 14116: 14112: 14111: 14109: 14108: 14103: 14098: 14092: 14090: 14081: 14080: 14078: 14077: 14072: 14066: 14064: 14056: 14055: 14035: 14034: 14031: 14030: 14028: 14027: 14022: 14017: 14012: 14010:Rebound effect 14007: 14002: 13997: 13991: 13988: 13987: 13970: 13969: 13966: 13965: 13962: 13961: 13959: 13958: 13953: 13951:Hypersexuality 13947: 13945: 13939: 13938: 13936: 13935: 13930: 13924: 13922: 13916: 13915: 13913: 13912: 13911: 13910: 13905: 13900: 13890: 13885: 13879: 13877: 13870: 13869: 13867: 13866: 13861: 13856: 13851: 13845: 13843: 13833: 13832: 13822: 13821: 13818: 13817: 13814: 13813: 13811: 13810: 13805: 13800: 13795: 13790: 13785: 13780: 13779: 13778: 13773: 13768: 13758: 13752: 13750: 13744: 13743: 13741: 13740: 13735: 13730: 13725: 13719: 13717: 13711: 13710: 13707: 13706: 13704: 13703: 13702: 13701: 13696: 13686: 13684:Panic disorder 13681: 13676: 13671: 13665: 13663: 13659: 13658: 13656: 13655: 13654: 13653: 13651:Claustrophobia 13643: 13642: 13641: 13636: 13634:Anthropophobia 13626: 13624:Social anxiety 13621: 13616: 13610: 13608: 13599: 13593: 13592: 13590: 13589: 13582: 13580: 13570: 13569: 13549: 13548: 13545: 13544: 13541: 13540: 13538: 13537: 13532: 13527: 13521: 13519: 13515: 13514: 13512: 13511: 13506: 13501: 13496: 13494:Pick's disease 13491: 13486: 13481: 13476: 13471: 13466: 13461: 13455: 13453: 13447: 13446: 13444: 13443: 13438: 13433: 13428: 13423: 13417: 13415: 13405: 13404: 13394: 13393: 13390: 13389: 13387: 13386: 13381: 13380: 13379: 13374: 13369: 13364: 13359: 13349: 13348: 13347: 13342: 13337: 13332: 13321: 13318: 13317: 13304: 13303: 13300: 13299: 13296: 13295: 13293: 13292: 13287: 13281: 13279: 13269: 13268: 13266: 13265: 13264: 13263: 13252: 13250: 13244: 13243: 13241: 13240: 13239: 13238: 13228: 13227: 13226: 13221: 13211: 13210: 13209: 13204: 13199: 13191: 13190: 13189: 13179: 13178: 13177: 13167: 13166: 13165: 13155: 13149: 13147: 13137: 13136: 13124: 13123: 13120: 13119: 13116: 13115: 13113: 13112: 13107: 13102: 13097: 13092: 13087: 13082: 13077: 13072: 13071: 13070: 13059: 13057: 13053: 13052: 13050: 13049: 13044: 13039: 13034: 13029: 13028: 13027: 13022: 13012: 13006: 13004: 12996: 12995: 12985: 12984: 12980:Classification 12972: 12971: 12964: 12957: 12949: 12940: 12939: 12936: 12935: 12933:article/287681 12924: 12912: 12911: 12909: 12905: 12904: 12901: 12900: 12889: 12878: 12867: 12852: 12837: 12821: 12816: 12815: 12813: 12812:Classification 12806: 12805: 12799: 12784: 12779: 12774: 12769: 12741: 12740:External links 12738: 12735: 12734: 12675: 12646:(4): 726–735. 12626: 12611: 12568: 12541:(4): 887–895. 12525: 12499: 12473: 12447: 12426:"What Is OCD?" 12416: 12385: 12354: 12323: 12305: 12294:on 8 July 2011 12270: 12245: 12218:(9): 669–686. 12198: 12179: 12153: 12125: 12105: 12087: 12056: 12029: 11998: 11979: 11948: 11897: 11885:ocdhistory.net 11869: 11862: 11840: 11826: 11807:(4): 273–280. 11791: 11784: 11761: 11742:(4): 283–295. 11726: 11708: 11693: 11655: 11648: 11603: 11588: 11581: 11561: 11554: 11536: 11514: 11463: 11434:(4): 401–411. 11414: 11387:(5): 367–383. 11371: 11328: 11301: 11286: 11271: 11219: 11208:(3): 335–347. 11192: 11173: 11146: 11109:BMC Psychiatry 11095: 11082: 11038: 11003: 10967: 10928: 10885: 10853: 10821: 10770: 10752: 10703: 10674:(2): 244–275. 10654: 10603: 10569: 10520: 10477: 10428: 10399:(8): 730–739. 10379: 10350: 10313:(5): 348–359. 10293: 10284: 10275: 10265: 10253: 10238: 10220: 10194: 10155: 10116: 10060: 10023:(5): 418–428. 10003: 9948: 9911: 9885: 9834: 9783: 9753: 9741: 9706: 9687:(3): 182–197. 9668: 9633: 9604:(5): 831–852. 9584: 9541: 9511: 9484:(4): 485–496. 9468: 9433: 9418: 9369: 9354: 9325:(3): 314–332. 9302: 9251: 9216: 9209: 9191: 9184: 9166: 9115: 9086:(8): 587–605. 9066: 9012: 8985:(3): 337–352. 8969: 8934: 8885: 8864:(5): 393–402. 8844: 8801: 8774:(7): 701–711. 8753: 8724:(3): 175–202. 8704: 8660: 8617: 8596:(5): 405–412. 8576: 8535: 8520: 8494: 8475:(2): 100–107. 8459: 8410: 8380:(1): 127–130. 8364: 8345:(2): 316–320. 8322: 8272: 8245:(6): 665–673. 8226: 8197:(4): 401–411. 8177: 8128: 8079: 8055: 8030: 8001: 7972:(5): 827–853. 7952: 7909: 7882:(6): 556–561. 7865: 7828:(4): 367–379. 7811: 7782:(7): 788–798. 7762: 7735:(3): 683–689. 7719: 7692:(6): 850–858. 7675: 7632: 7605:(3): 362–371. 7589: 7540: 7494: 7449: 7406: 7380: 7331: 7304:(5): 385–387. 7288: 7257:(5): 649–650. 7237: 7216:(3): 375–377. 7196: 7167:(2): e100741. 7147: 7096: 7043: 7017: 6990:(5): 784–799. 6974: 6955: 6912: 6893:(6): 465–474. 6874: 6853:(2): 108–111. 6833: 6782: 6745:BMC Psychiatry 6728: 6693: 6666:(1–2): 57–64. 6650: 6606: 6563: 6524: 6505:(5): 489–498. 6489: 6462:(1): 152–165. 6446: 6417:(8): 580–593. 6397: 6341: 6330:(4): 295–302. 6314: 6263: 6236:(1): 137–151. 6219: 6168: 6141: 6106: 6079:(6): 410–424. 6063: 6044:(4): 266–274. 6028: 5985: 5958:(1): 111–120. 5942: 5923:(9): 881–902. 5907: 5888:(3): 343–353. 5872: 5826: 5804: 5777:(3): 343–353. 5761: 5742:(4): 383–400. 5723: 5674: 5667: 5646: 5620: 5601: 5582:(3): 213–221. 5563: 5525: 5488:(2): 165–181. 5472: 5447: 5408: 5382: 5333: 5304:(9): 761–767. 5284: 5263: 5226: 5219: 5195: 5156: 5123: 5070: 5017: 4991: 4955: 4938: 4913: 4894:(10): 925–41. 4878: 4842: 4835: 4809: 4802: 4780: 4761:(4): 433–440. 4745: 4706: 4677:(5): 580–589. 4657: 4638:(3): 283–313. 4622: 4593: 4570:(1): 150–158. 4550: 4515: 4496:(4): 335–341. 4477: 4426: 4374: 4328: 4287: 4262: 4236: 4185: 4144: 4101: 4047: 4018:(8): 850–855. 3995: 3961: 3932:(3): 375–391. 3912: 3884: 3873:. October 2022 3858: 3833: 3801: 3794: 3772: 3743:(8): 681–696. 3723: 3704:(3): 300–308. 3688: 3673:(3): 239–245. 3648: 3621:(4): 965–981. 3602: 3573:(3): 319–335. 3553: 3524:(4): 390–408. 3504: 3450: 3429: 3398:(6): 495–500. 3378: 3350: 3337:psychiatry.org 3314: 3282: 3246: 3227:(3): 257–267. 3206: 3169:BMC Psychiatry 3146: 3127:(7): 646–653. 3100: 3071:Pergamon Press 3050: 3043: 2973: 2907: 2906: 2904: 2901: 2900: 2899: 2894: 2889: 2884: 2879: 2874: 2869: 2864: 2859: 2854: 2849: 2842: 2839: 2829: 2828: 2811:September 2024 2779: 2777: 2770: 2764: 2761: 2753: 2750: 2684: 2681: 2680: 2679: 2662: 2641: 2628: 2615: 2607:Matchstick Men 2602: 2599:Jack Nicholson 2597:(1997), actor 2589: 2585:The Odd Couple 2571: 2568: 2550: 2547: 2514:Greta Thunberg 2468:Samuel Johnson 2442: 2439: 2375:psychoanalysis 2236: 2233: 2220: 2214: 2208: 2206: 97.5–105 2202: 2196: 2190: 2184: 2178: 2172: 2166: 2160: 2154: 2148: 2147: 2129: 2126: 2113: 2110: 2100: 2097: 2039: 2036: 2001:antipsychotics 1938: 1935: 1907:psychoanalysis 1903:psychodynamics 1818: 1815: 1803: 1800: 1769: 1766: 1687: 1684: 1623:antipsychotics 1577: 1574: 1513: 1510: 1494:medial frontal 1485:medial frontal 1383:temporal gyrus 1357: 1354: 1349:Main article: 1346: 1343: 1330: 1327: 1299: 1296: 1275:frontal cortex 1267: 1264: 1153: 1150: 1128: 1125: 1109:Main article: 1106: 1103: 1097:, and 30% for 1095:panic disorder 1024:drug addiction 953: 950: 933: 930: 921: 913: 905: 902: 866:spatial memory 856: 853: 812: 809: 687:Main article: 684: 681: 558:Main article: 555: 552: 490: 487: 209: 208: 205: 201: 200: 187: 183: 182: 164: 158: 157: 154: 148: 147: 130: 124: 123: 120: 116: 115: 102: 96: 95: 85: 79: 78: 73: 67: 66: 62: 61: 53: 52: 44: 26: 9: 6: 4: 3: 2: 15536: 15525: 15522: 15520: 15517: 15515: 15512: 15510: 15507: 15506: 15504: 15489: 15486: 15484: 15481: 15477: 15474: 15473: 15472: 15469: 15467: 15464: 15462: 15459: 15457: 15454: 15452: 15449: 15445: 15442: 15440: 15437: 15435: 15432: 15431: 15430: 15427: 15425: 15422: 15420: 15417: 15415: 15412: 15410: 15407: 15405: 15402: 15400: 15397: 15395: 15392: 15390: 15389:Digital detox 15387: 15385: 15382: 15380: 15379:Cyberbullying 15377: 15373: 15370: 15369: 15368: 15365: 15363: 15360: 15358: 15355: 15353: 15350: 15349: 15347: 15343: 15337: 15334: 15332: 15329: 15325: 15322: 15320: 15317: 15316: 15315: 15312: 15310: 15307: 15305: 15302: 15300: 15297: 15295: 15292: 15288: 15285: 15283: 15280: 15278: 15275: 15274: 15273: 15270: 15269: 15267: 15261: 15253: 15250: 15248: 15245: 15243: 15240: 15238: 15235: 15234: 15233: 15230: 15226: 15223: 15222: 15221: 15218: 15216: 15213: 15209: 15206: 15204: 15201: 15199: 15196: 15194: 15191: 15189: 15186: 15184: 15181: 15179: 15176: 15175: 15174: 15171: 15169: 15166: 15164: 15161: 15160: 15158: 15154: 15148: 15145: 15143: 15140: 15138: 15135: 15131: 15128: 15127: 15126: 15123: 15121: 15118: 15116: 15113: 15111: 15108: 15106: 15103: 15102: 15100: 15094: 15090: 15083: 15078: 15076: 15071: 15069: 15064: 15063: 15060: 15047: 15043: 15039: 15035: 15031: 15028: 15025: 15021: 15018: 15017: 15015: 15011: 15004: 14997: 14992: 14989: 14982: 14977: 14974: 14970: 14966: 14962: 14958: 14954: 14947: 14942: 14941: 14939: 14937: 14933: 14929: 14919: 14914: 14912: 14907: 14905: 14900: 14899: 14896: 14884: 14881: 14879: 14876: 14874: 14871: 14869: 14866: 14864: 14861: 14859: 14856: 14854: 14851: 14849: 14846: 14844: 14841: 14839: 14836: 14834: 14831: 14829: 14826: 14825: 14823: 14821: 14817: 14807: 14806: 14802: 14799: 14795: 14793: 14792: 14788: 14786: 14783: 14781: 14780: 14776: 14774: 14773: 14769: 14767: 14766: 14762: 14761: 14759: 14755: 14745: 14744: 14743:Just Checking 14740: 14738: 14737: 14733: 14732: 14730: 14726: 14720: 14719: 14715: 14713: 14712: 14708: 14706: 14705: 14701: 14700: 14698: 14694: 14691: 14687: 14684: 14680: 14670: 14667: 14665: 14662: 14659: 14655: 14652: 14650: 14647: 14646: 14644: 14640: 14634: 14631: 14629: 14626: 14625: 14623: 14619: 14609: 14606: 14605: 14603: 14601: 14597: 14591: 14588: 14587: 14585: 14583: 14579: 14573: 14570: 14569: 14567: 14565: 14561: 14555: 14552: 14550: 14547: 14545: 14542: 14540: 14537: 14535: 14532: 14530: 14527: 14525: 14522: 14521: 14519: 14517: 14513: 14510: 14508: 14507:Serotonergics 14504: 14501: 14497: 14490: 14487: 14485: 14482: 14480: 14477: 14475: 14471: 14468: 14465: 14461: 14458: 14455: 14452: 14450: 14447: 14445: 14441: 14438: 14435: 14432: 14430: 14427: 14425: 14422: 14420: 14417: 14415: 14412: 14410: 14407: 14405: 14401: 14398: 14397: 14395: 14391: 14381: 14378: 14376: 14370: 14368: 14362: 14360: 14354: 14352: 14349: 14347: 14341: 14339: 14333: 14331: 14324: 14323: 14321: 14317: 14311: 14308: 14306: 14303: 14301: 14298: 14295: 14291: 14290:Basal ganglia 14288: 14287: 14285: 14281: 14278: 14276: 14272: 14266: 14263: 14261: 14258: 14257: 14255: 14251: 14247: 14240: 14235: 14233: 14228: 14226: 14221: 14220: 14217: 14201: 14198: 14196: 14193: 14191: 14188: 14186: 14183: 14182: 14179: 14172: 14168: 14154: 14151: 14150: 14148: 14144: 14138: 14135: 14133: 14130: 14128: 14125: 14123: 14120: 14119: 14117: 14115:Schizophrenia 14113: 14107: 14104: 14102: 14099: 14097: 14094: 14093: 14091: 14086: 14082: 14076: 14073: 14071: 14068: 14067: 14065: 14061: 14057: 14053: 14049: 14045: 14044:Schizophrenia 14040: 14036: 14026: 14023: 14021: 14018: 14016: 14013: 14011: 14008: 14006: 14003: 14001: 13998: 13996: 13995:Drug overdose 13993: 13992: 13989: 13984: 13980: 13975: 13971: 13957: 13954: 13952: 13949: 13948: 13946: 13944: 13943:Sexual desire 13940: 13934: 13931: 13929: 13926: 13925: 13923: 13921: 13917: 13909: 13906: 13904: 13901: 13899: 13896: 13895: 13894: 13891: 13889: 13886: 13884: 13881: 13880: 13878: 13876: 13871: 13865: 13862: 13860: 13857: 13855: 13852: 13850: 13847: 13846: 13844: 13842: 13838: 13834: 13827: 13823: 13809: 13806: 13804: 13801: 13799: 13796: 13794: 13791: 13789: 13786: 13784: 13781: 13777: 13774: 13772: 13769: 13767: 13764: 13763: 13762: 13759: 13757: 13754: 13753: 13751: 13749: 13745: 13739: 13736: 13734: 13731: 13729: 13726: 13724: 13721: 13720: 13718: 13716: 13712: 13700: 13697: 13695: 13692: 13691: 13690: 13687: 13685: 13682: 13680: 13677: 13675: 13672: 13670: 13667: 13666: 13664: 13660: 13652: 13649: 13648: 13647: 13644: 13640: 13637: 13635: 13632: 13631: 13630: 13629:Social phobia 13627: 13625: 13622: 13620: 13617: 13615: 13612: 13611: 13609: 13607: 13603: 13600: 13598: 13594: 13587: 13584: 13583: 13581: 13579: 13575: 13571: 13567: 13564:-related and 13563: 13559: 13554: 13550: 13536: 13533: 13531: 13528: 13526: 13523: 13522: 13520: 13516: 13510: 13507: 13505: 13502: 13500: 13497: 13495: 13492: 13490: 13487: 13485: 13482: 13480: 13477: 13475: 13472: 13470: 13467: 13465: 13462: 13460: 13457: 13456: 13454: 13452: 13448: 13442: 13439: 13437: 13434: 13432: 13429: 13427: 13424: 13422: 13419: 13418: 13416: 13414: 13410: 13406: 13399: 13395: 13385: 13382: 13378: 13375: 13373: 13370: 13368: 13365: 13363: 13360: 13358: 13355: 13354: 13353: 13350: 13346: 13343: 13341: 13338: 13336: 13333: 13331: 13328: 13327: 13326: 13323: 13322: 13319: 13314: 13309: 13305: 13291: 13288: 13286: 13283: 13282: 13280: 13277: 13270: 13262: 13259: 13258: 13257: 13254: 13253: 13251: 13249: 13245: 13237: 13234: 13233: 13232: 13229: 13225: 13222: 13220: 13217: 13216: 13215: 13212: 13208: 13205: 13203: 13200: 13198: 13195: 13194: 13192: 13188: 13185: 13184: 13183: 13180: 13176: 13173: 13172: 13171: 13168: 13164: 13161: 13160: 13159: 13156: 13154: 13151: 13150: 13148: 13146: 13142: 13138: 13134: 13129: 13125: 13111: 13108: 13106: 13103: 13101: 13098: 13096: 13093: 13091: 13088: 13086: 13083: 13081: 13078: 13076: 13073: 13069: 13066: 13065: 13064: 13061: 13060: 13058: 13054: 13048: 13045: 13043: 13040: 13038: 13035: 13033: 13030: 13026: 13023: 13021: 13018: 13017: 13016: 13013: 13011: 13008: 13007: 13005: 13001: 12997: 12990: 12986: 12981: 12977: 12970: 12965: 12963: 12958: 12956: 12951: 12950: 12947: 12934: 12930: 12929: 12925: 12923: 12919: 12918: 12914: 12913: 12910: 12906: 12899: 12895: 12894: 12890: 12888: 12884: 12883: 12879: 12877: 12873: 12872: 12868: 12866: 12862: 12861: 12857: 12853: 12851: 12847: 12846: 12842: 12838: 12836: 12832: 12831: 12827: 12823: 12822: 12819: 12814: 12810: 12802: 12796: 12792: 12791: 12785: 12783: 12780: 12778: 12775: 12773: 12770: 12768: 12764: 12759: 12755: 12754: 12749: 12744: 12743: 12730: 12726: 12721: 12716: 12712: 12708: 12703: 12698: 12694: 12690: 12686: 12679: 12671: 12667: 12662: 12657: 12653: 12649: 12645: 12641: 12637: 12630: 12622: 12615: 12607: 12603: 12599: 12595: 12591: 12587: 12583: 12579: 12572: 12564: 12560: 12556: 12552: 12548: 12544: 12540: 12536: 12529: 12514: 12510: 12503: 12488: 12484: 12477: 12462: 12458: 12451: 12435: 12431: 12427: 12420: 12404: 12400: 12396: 12389: 12373: 12369: 12365: 12358: 12342: 12338: 12334: 12327: 12319: 12315: 12309: 12290: 12283: 12282: 12274: 12259: 12255: 12249: 12241: 12237: 12233: 12229: 12225: 12221: 12217: 12213: 12209: 12202: 12194: 12190: 12183: 12175: 12163: 12157: 12142: 12141: 12140:Rolling Stone 12136: 12129: 12121: 12120: 12115: 12109: 12101: 12097: 12091: 12075: 12071: 12067: 12060: 12052: 12048: 12044: 12040: 12033: 12017: 12013: 12009: 12002: 11994: 11990: 11983: 11967: 11963: 11959: 11952: 11944: 11940: 11935: 11930: 11925: 11920: 11916: 11912: 11908: 11901: 11886: 11882: 11876: 11874: 11865: 11859: 11855: 11851: 11844: 11836: 11830: 11822: 11818: 11814: 11810: 11806: 11802: 11795: 11787: 11781: 11777: 11776: 11771: 11765: 11757: 11753: 11749: 11745: 11741: 11737: 11730: 11722: 11715: 11713: 11704: 11697: 11689: 11685: 11681: 11677: 11673: 11669: 11662: 11660: 11651: 11645: 11641: 11640: 11632: 11630: 11628: 11626: 11624: 11622: 11620: 11618: 11616: 11614: 11612: 11610: 11608: 11599: 11592: 11584: 11578: 11574: 11573: 11565: 11557: 11551: 11547: 11540: 11524: 11518: 11510: 11506: 11501: 11496: 11491: 11486: 11482: 11478: 11474: 11467: 11459: 11455: 11450: 11445: 11441: 11437: 11433: 11429: 11425: 11418: 11410: 11406: 11402: 11398: 11394: 11390: 11386: 11382: 11375: 11367: 11363: 11359: 11355: 11351: 11347: 11343: 11339: 11332: 11324: 11320: 11316: 11312: 11305: 11297: 11290: 11282: 11275: 11267: 11263: 11258: 11253: 11249: 11245: 11241: 11237: 11233: 11226: 11224: 11215: 11211: 11207: 11203: 11196: 11189: 11185: 11182: 11177: 11169: 11165: 11161: 11157: 11150: 11142: 11138: 11133: 11128: 11123: 11118: 11114: 11110: 11106: 11099: 11092: 11086: 11078: 11074: 11070: 11066: 11062: 11058: 11054: 11050: 11042: 11034: 11030: 11026: 11022: 11018: 11014: 11007: 10999: 10995: 10991: 10987: 10986: 10978: 10971: 10963: 10959: 10955: 10951: 10947: 10943: 10939: 10932: 10924: 10920: 10916: 10912: 10908: 10904: 10900: 10896: 10889: 10870: 10863: 10857: 10838: 10831: 10825: 10817: 10813: 10808: 10803: 10798: 10793: 10789: 10785: 10781: 10774: 10766: 10762: 10756: 10748: 10744: 10739: 10734: 10730: 10726: 10722: 10718: 10714: 10707: 10699: 10695: 10690: 10685: 10681: 10677: 10673: 10669: 10665: 10658: 10650: 10646: 10641: 10636: 10631: 10626: 10622: 10618: 10614: 10607: 10599: 10595: 10591: 10587: 10583: 10582:NIHR Evidence 10579: 10573: 10565: 10561: 10556: 10551: 10547: 10543: 10539: 10535: 10531: 10524: 10516: 10512: 10508: 10504: 10500: 10496: 10492: 10488: 10481: 10473: 10469: 10464: 10459: 10455: 10451: 10447: 10443: 10439: 10432: 10424: 10420: 10415: 10410: 10406: 10402: 10398: 10394: 10390: 10383: 10375: 10371: 10367: 10363: 10362: 10354: 10346: 10342: 10338: 10334: 10330: 10326: 10321: 10316: 10312: 10308: 10304: 10297: 10288: 10279: 10269: 10260: 10258: 10249: 10245: 10241: 10235: 10231: 10224: 10209: 10205: 10198: 10190: 10186: 10182: 10178: 10174: 10170: 10166: 10159: 10151: 10147: 10143: 10139: 10135: 10131: 10127: 10120: 10105: 10101: 10096: 10091: 10087: 10083: 10079: 10075: 10074:CNS Spectrums 10071: 10064: 10056: 10052: 10048: 10044: 10040: 10036: 10031: 10026: 10022: 10018: 10014: 10007: 9999: 9995: 9991: 9987: 9983: 9979: 9975: 9971: 9967: 9963: 9959: 9952: 9944: 9940: 9936: 9932: 9928: 9924: 9923: 9915: 9909: 9905: 9902: 9898: 9892: 9890: 9881: 9877: 9872: 9867: 9862: 9861:10.2196/26736 9857: 9854:(2): e26736. 9853: 9849: 9845: 9838: 9830: 9826: 9821: 9816: 9811: 9810:10.2196/35940 9806: 9803:(4): e35940. 9802: 9798: 9794: 9787: 9771: 9767: 9760: 9758: 9748: 9746: 9737: 9733: 9729: 9725: 9721: 9717: 9710: 9702: 9698: 9694: 9690: 9686: 9682: 9675: 9673: 9664: 9660: 9656: 9652: 9648: 9644: 9637: 9629: 9625: 9620: 9615: 9611: 9607: 9603: 9599: 9595: 9588: 9580: 9576: 9572: 9568: 9564: 9560: 9556: 9552: 9545: 9530: 9526: 9520: 9518: 9516: 9507: 9503: 9499: 9495: 9491: 9487: 9483: 9479: 9472: 9464: 9460: 9456: 9452: 9448: 9444: 9437: 9430: 9425: 9423: 9414: 9410: 9405: 9400: 9396: 9392: 9388: 9384: 9380: 9373: 9365: 9358: 9350: 9346: 9341: 9336: 9332: 9328: 9324: 9320: 9316: 9309: 9307: 9298: 9294: 9289: 9284: 9279: 9274: 9270: 9266: 9262: 9255: 9247: 9243: 9239: 9235: 9231: 9227: 9220: 9212: 9206: 9202: 9195: 9187: 9181: 9177: 9170: 9162: 9158: 9153: 9148: 9143: 9138: 9134: 9130: 9126: 9119: 9111: 9107: 9103: 9099: 9094: 9089: 9085: 9081: 9077: 9070: 9062: 9058: 9053: 9048: 9043: 9038: 9034: 9030: 9026: 9019: 9017: 9008: 9004: 9000: 8996: 8992: 8988: 8984: 8980: 8973: 8965: 8961: 8957: 8953: 8949: 8945: 8938: 8930: 8926: 8921: 8916: 8912: 8908: 8904: 8900: 8896: 8889: 8881: 8877: 8872: 8867: 8863: 8859: 8855: 8848: 8840: 8836: 8832: 8828: 8824: 8820: 8816: 8812: 8805: 8797: 8793: 8789: 8785: 8781: 8777: 8773: 8769: 8762: 8760: 8758: 8749: 8745: 8740: 8735: 8731: 8727: 8723: 8719: 8715: 8708: 8700: 8696: 8692: 8688: 8684: 8680: 8676: 8672: 8664: 8656: 8652: 8648: 8644: 8640: 8636: 8632: 8628: 8621: 8613: 8609: 8604: 8599: 8595: 8591: 8587: 8580: 8572: 8568: 8563: 8558: 8554: 8550: 8546: 8539: 8531: 8527: 8523: 8517: 8513: 8509: 8505: 8498: 8490: 8486: 8482: 8478: 8474: 8470: 8463: 8455: 8451: 8446: 8441: 8437: 8433: 8429: 8425: 8421: 8414: 8407: 8403: 8399: 8395: 8391: 8387: 8383: 8379: 8375: 8368: 8360: 8356: 8352: 8348: 8344: 8340: 8333: 8331: 8329: 8327: 8318: 8314: 8310: 8306: 8302: 8298: 8294: 8290: 8283: 8281: 8279: 8277: 8268: 8264: 8260: 8256: 8252: 8248: 8244: 8240: 8233: 8231: 8222: 8218: 8213: 8208: 8204: 8200: 8196: 8192: 8188: 8181: 8173: 8169: 8164: 8159: 8155: 8151: 8147: 8143: 8139: 8132: 8124: 8120: 8116: 8112: 8107: 8102: 8098: 8094: 8090: 8083: 8068: 8062: 8060: 8044: 8040: 8034: 8018: 8014: 8008: 8006: 7997: 7993: 7988: 7983: 7979: 7975: 7971: 7967: 7963: 7956: 7948: 7944: 7940: 7936: 7932: 7928: 7924: 7920: 7913: 7905: 7901: 7897: 7893: 7889: 7885: 7881: 7877: 7869: 7861: 7857: 7853: 7849: 7844: 7843:2027.42/98412 7839: 7835: 7831: 7827: 7823: 7815: 7807: 7803: 7798: 7793: 7789: 7785: 7781: 7777: 7773: 7766: 7758: 7754: 7750: 7746: 7742: 7738: 7734: 7730: 7723: 7715: 7711: 7707: 7703: 7699: 7695: 7691: 7687: 7679: 7671: 7667: 7663: 7659: 7655: 7651: 7647: 7643: 7636: 7628: 7624: 7620: 7616: 7612: 7608: 7604: 7600: 7593: 7585: 7581: 7576: 7571: 7567: 7563: 7559: 7555: 7551: 7544: 7536: 7532: 7528: 7524: 7520: 7516: 7512: 7508: 7501: 7499: 7490: 7486: 7481: 7476: 7472: 7468: 7464: 7460: 7453: 7445: 7441: 7437: 7433: 7429: 7425: 7421: 7417: 7410: 7394: 7390: 7384: 7376: 7372: 7367: 7362: 7358: 7354: 7350: 7346: 7342: 7335: 7327: 7323: 7319: 7315: 7311: 7307: 7303: 7299: 7292: 7284: 7280: 7275: 7270: 7265: 7260: 7256: 7252: 7248: 7241: 7233: 7229: 7224: 7219: 7215: 7211: 7207: 7200: 7192: 7188: 7183: 7178: 7174: 7170: 7166: 7162: 7158: 7151: 7143: 7139: 7134: 7129: 7124: 7119: 7115: 7111: 7107: 7100: 7092: 7088: 7083: 7078: 7073: 7068: 7064: 7060: 7059: 7054: 7047: 7031: 7027: 7021: 7013: 7009: 7005: 7001: 6997: 6993: 6989: 6985: 6978: 6971: 6967: 6964: 6959: 6951: 6947: 6943: 6939: 6935: 6931: 6927: 6923: 6916: 6908: 6904: 6900: 6896: 6892: 6888: 6881: 6879: 6870: 6866: 6861: 6856: 6852: 6848: 6844: 6837: 6829: 6825: 6820: 6815: 6810: 6805: 6801: 6797: 6793: 6786: 6778: 6774: 6769: 6764: 6759: 6754: 6750: 6746: 6742: 6735: 6733: 6724: 6720: 6716: 6712: 6708: 6704: 6697: 6689: 6685: 6681: 6677: 6673: 6669: 6665: 6661: 6654: 6646: 6642: 6637: 6632: 6629:(1): 98–113. 6628: 6624: 6620: 6613: 6611: 6602: 6598: 6594: 6590: 6586: 6582: 6578: 6574: 6567: 6559: 6555: 6551: 6547: 6543: 6539: 6531: 6529: 6520: 6516: 6512: 6508: 6504: 6500: 6493: 6485: 6481: 6477: 6473: 6469: 6465: 6461: 6457: 6450: 6442: 6438: 6433: 6428: 6424: 6420: 6416: 6412: 6408: 6401: 6393: 6389: 6384: 6379: 6374: 6369: 6365: 6361: 6357: 6350: 6348: 6346: 6337: 6333: 6329: 6325: 6318: 6310: 6306: 6301: 6296: 6291: 6286: 6282: 6278: 6274: 6267: 6259: 6255: 6251: 6247: 6243: 6239: 6235: 6231: 6223: 6215: 6211: 6206: 6201: 6196: 6191: 6187: 6183: 6179: 6172: 6164: 6160: 6156: 6152: 6145: 6137: 6133: 6129: 6125: 6121: 6117: 6110: 6102: 6098: 6094: 6090: 6086: 6082: 6078: 6074: 6067: 6059: 6055: 6051: 6050:10.5080/u7172 6047: 6043: 6039: 6032: 6024: 6020: 6016: 6012: 6008: 6004: 6000: 5996: 5989: 5981: 5977: 5973: 5969: 5965: 5961: 5957: 5953: 5946: 5938: 5934: 5930: 5926: 5922: 5918: 5911: 5903: 5899: 5895: 5891: 5887: 5883: 5876: 5868: 5864: 5860: 5856: 5852: 5848: 5844: 5840: 5833: 5831: 5822: 5815: 5808: 5800: 5796: 5792: 5788: 5784: 5780: 5776: 5772: 5765: 5757: 5753: 5749: 5745: 5741: 5737: 5730: 5728: 5719: 5715: 5711: 5707: 5702: 5697: 5693: 5689: 5685: 5678: 5670: 5664: 5660: 5653: 5651: 5635: 5631: 5624: 5616: 5612: 5605: 5597: 5593: 5589: 5585: 5581: 5577: 5570: 5568: 5559: 5555: 5551: 5547: 5543: 5539: 5532: 5530: 5521: 5517: 5513: 5509: 5504: 5499: 5495: 5491: 5487: 5483: 5476: 5461: 5457: 5451: 5443: 5439: 5435: 5431: 5427: 5423: 5419: 5412: 5396: 5392: 5386: 5378: 5374: 5369: 5364: 5360: 5356: 5352: 5348: 5344: 5337: 5329: 5325: 5321: 5317: 5312: 5307: 5303: 5299: 5295: 5288: 5273: 5267: 5259: 5255: 5251: 5247: 5243: 5239: 5238: 5230: 5222: 5216: 5212: 5208: 5207: 5199: 5191: 5187: 5183: 5179: 5175: 5171: 5167: 5160: 5142: 5135: 5134: 5127: 5119: 5115: 5110: 5105: 5101: 5097: 5093: 5089: 5085: 5081: 5074: 5066: 5062: 5057: 5052: 5048: 5044: 5040: 5036: 5032: 5028: 5021: 5006: 5002: 4995: 4976: 4969: 4962: 4960: 4951: 4950: 4942: 4927: 4923: 4917: 4909: 4905: 4901: 4897: 4893: 4889: 4882: 4873: 4868: 4864: 4860: 4853: 4846: 4838: 4832: 4828: 4824: 4820: 4813: 4805: 4799: 4794: 4793: 4784: 4776: 4772: 4768: 4764: 4760: 4756: 4749: 4741: 4737: 4733: 4729: 4725: 4721: 4717: 4710: 4702: 4698: 4693: 4688: 4684: 4680: 4676: 4672: 4668: 4661: 4653: 4649: 4645: 4641: 4637: 4633: 4626: 4610: 4606: 4600: 4598: 4588: 4583: 4578: 4573: 4569: 4565: 4561: 4554: 4546: 4542: 4538: 4534: 4531:(4): 743–58. 4530: 4526: 4519: 4511: 4507: 4503: 4499: 4495: 4491: 4484: 4482: 4473: 4469: 4464: 4459: 4455: 4451: 4447: 4443: 4442: 4437: 4430: 4422: 4418: 4413: 4408: 4404: 4400: 4396: 4392: 4388: 4381: 4379: 4370: 4366: 4362: 4358: 4354: 4350: 4346: 4342: 4335: 4333: 4324: 4320: 4315: 4310: 4306: 4302: 4298: 4291: 4276: 4272: 4266: 4250: 4246: 4240: 4232: 4228: 4223: 4218: 4213: 4208: 4204: 4200: 4196: 4189: 4181: 4177: 4172: 4167: 4163: 4159: 4155: 4148: 4140: 4136: 4132: 4128: 4124: 4120: 4116: 4112: 4105: 4097: 4093: 4088: 4083: 4078: 4073: 4069: 4065: 4061: 4054: 4052: 4043: 4039: 4034: 4029: 4025: 4021: 4017: 4013: 4009: 4002: 4000: 3991: 3987: 3983: 3979: 3975: 3968: 3966: 3957: 3953: 3948: 3943: 3939: 3935: 3931: 3927: 3923: 3916: 3901: 3897: 3891: 3889: 3872: 3868: 3862: 3847: 3843: 3837: 3822: 3818: 3812: 3810: 3808: 3806: 3797: 3791: 3787: 3783: 3776: 3768: 3764: 3759: 3754: 3750: 3746: 3742: 3738: 3734: 3727: 3719: 3715: 3711: 3707: 3703: 3699: 3692: 3684: 3680: 3676: 3672: 3668: 3664: 3657: 3655: 3653: 3644: 3640: 3636: 3632: 3628: 3624: 3620: 3616: 3609: 3607: 3598: 3594: 3589: 3584: 3580: 3576: 3572: 3568: 3564: 3557: 3549: 3545: 3540: 3535: 3531: 3527: 3523: 3519: 3515: 3508: 3500: 3496: 3491: 3486: 3481: 3476: 3472: 3468: 3464: 3457: 3455: 3439: 3433: 3425: 3421: 3416: 3411: 3406: 3401: 3397: 3393: 3389: 3382: 3367: 3366: 3361: 3354: 3339: 3338: 3333: 3327: 3325: 3323: 3321: 3319: 3302: 3300: 3295: 3289: 3287: 3271:. p. 142 3270: 3269: 3260: 3253: 3251: 3242: 3238: 3234: 3230: 3226: 3222: 3215: 3213: 3211: 3202: 3198: 3193: 3188: 3183: 3178: 3174: 3170: 3166: 3159: 3157: 3155: 3153: 3151: 3142: 3138: 3134: 3130: 3126: 3122: 3115: 3113: 3111: 3109: 3107: 3105: 3096: 3092: 3088: 3084: 3080: 3076: 3072: 3068: 3064: 3057: 3055: 3046: 3040: 3036: 3032: 3031: 3024: 3022: 3020: 3018: 3016: 3014: 3012: 3010: 3008: 3006: 3004: 3002: 3000: 2998: 2996: 2994: 2992: 2990: 2988: 2986: 2984: 2982: 2980: 2978: 2961: 2957: 2955: 2950: 2943: 2941: 2939: 2937: 2935: 2933: 2931: 2929: 2927: 2925: 2923: 2921: 2919: 2917: 2915: 2913: 2908: 2898: 2895: 2893: 2890: 2888: 2885: 2883: 2880: 2878: 2875: 2873: 2870: 2868: 2865: 2863: 2860: 2858: 2855: 2853: 2850: 2848: 2845: 2844: 2838: 2836: 2825: 2822: 2814: 2804: 2800: 2796: 2790: 2789: 2785: 2780:This section 2778: 2774: 2769: 2768: 2759: 2752:Other animals 2749: 2747: 2743: 2739: 2735: 2731: 2727: 2723: 2718: 2716: 2712: 2708: 2704: 2700: 2696: 2692: 2690: 2677: 2673: 2670:(2019) stars 2669: 2668: 2663: 2660: 2656: 2652: 2648: 2647: 2643:In the novel 2642: 2639: 2635: 2634: 2629: 2626: 2622: 2621: 2616: 2613: 2609: 2608: 2603: 2600: 2596: 2595: 2590: 2587: 2586: 2581: 2580: 2579: 2577: 2564: 2560: 2555: 2546: 2544: 2543:David Beckham 2539: 2536: 2535:Gabriel Boric 2531: 2528: 2527: 2526:Rolling Stone 2522: 2517: 2515: 2510: 2508: 2504: 2499: 2497: 2496: 2491: 2490:Howard Hughes 2486: 2484: 2480: 2479:Sigmund Freud 2476: 2471: 2469: 2466: 2465:lexicographer 2461: 2459: 2458: 2453: 2452: 2447: 2441:Notable cases 2438: 2436: 2431: 2429: 2425: 2421: 2416: 2412: 2407: 2405: 2401: 2397: 2392: 2388: 2383: 2381: 2380:psychotherapy 2376: 2371: 2370:Sigmund Freud 2367: 2363: 2362:Karl Westphal 2359: 2355: 2352: 2348: 2343: 2341: 2337: 2333: 2329: 2325: 2321: 2317: 2312: 2309: 2305: 2301: 2297: 2295: 2290: 2286: 2285: 2280: 2276: 2272: 2271:John Climacus 2267: 2265: 2261: 2257: 2253: 2249: 2245: 2241: 2232: 2224: >120 2200: 90–97.5 2194: 82.5–90 2188: 75–82.5 2182: 67.5–75 2176: 60–67.5 2170: 52.5–60 2164: 45–52.5 2152: no data 2145: 2140: 2135: 2125: 2123: 2118: 2109: 2105: 2096: 2093: 2089: 2088:psychosurgery 2084: 2082: 2078: 2074: 2070: 2066: 2062: 2058: 2054: 2050: 2048: 2044: 2035: 2033: 2029: 2025: 2020: 2015: 2011: 2007: 2002: 1998: 1995:In 2006, the 1993: 1991: 1987: 1983: 1981: 1975: 1972: 1966: 1964: 1960: 1956: 1952: 1943: 1934: 1930: 1928: 1924: 1920: 1916: 1912: 1908: 1904: 1900: 1895: 1893: 1889: 1885: 1881: 1877: 1875: 1871: 1867: 1863: 1859: 1855: 1853: 1847: 1844: 1840: 1836: 1832: 1823: 1814: 1812: 1808: 1799: 1795: 1793: 1789: 1788: 1783: 1779: 1775: 1765: 1761: 1757: 1753: 1751: 1745: 1743: 1738: 1734: 1730: 1728: 1722: 1718: 1716: 1712: 1707: 1705: 1701: 1700:social worker 1697: 1693: 1683: 1681: 1677: 1673: 1670: 1669:cerebrospinal 1666: 1663: 1662:glutamatergic 1658: 1656: 1652: 1648: 1644: 1640: 1636: 1635:autoreceptors 1632: 1628: 1624: 1620: 1615: 1613: 1609: 1605: 1601: 1596: 1592: 1588: 1584: 1573: 1571: 1567: 1561: 1559: 1555: 1551: 1547: 1543: 1538: 1537:heterogeneity 1533: 1531: 1527: 1522: 1520: 1509: 1507: 1503: 1499: 1495: 1490: 1486: 1482: 1478: 1473: 1471: 1467: 1463: 1459: 1455: 1451: 1447: 1443: 1439: 1435: 1431: 1427: 1422: 1420: 1416: 1412: 1411:orbital gyrus 1408: 1404: 1400: 1396: 1392: 1388: 1384: 1380: 1376: 1372: 1362: 1352: 1342: 1340: 1336: 1326: 1324: 1319: 1317: 1313: 1312:streptococcal 1309: 1305: 1295: 1293: 1289: 1286:, which is a 1285: 1280: 1276: 1272: 1263: 1261: 1257: 1253: 1248: 1246: 1241: 1239: 1234: 1232: 1228: 1224: 1220: 1216: 1211: 1209: 1205: 1201: 1197: 1193: 1188: 1186: 1182: 1178: 1173: 1169: 1167: 1163: 1159: 1149: 1146: 1143: 1139: 1136: 1133: 1124: 1122: 1118: 1112: 1102: 1100: 1096: 1092: 1088: 1084: 1080: 1076: 1072: 1068: 1063: 1061: 1060:Tourettic OCD 1057: 1053: 1049: 1045: 1041: 1040:perseveration 1037: 1032: 1029: 1025: 1020: 1018: 1014: 1009: 1005: 1003: 999: 995: 991: 988:, ASD, ADHD, 987: 983: 979: 975: 971: 967: 963: 959: 949: 947: 942: 938: 932:Pediatric OCD 925: 918: 911: 901: 898: 897:meta-analysis 893: 891: 887: 883: 879: 875: 871: 870:verbal memory 867: 863: 852: 848: 846: 842: 841:United States 838: 834: 829: 827: 822: 818: 808: 805: 803: 799: 795: 791: 787: 783: 779: 774: 771: 766: 764: 760: 754: 752: 748: 742: 740: 736: 732: 728: 724: 720: 716: 712: 708: 707:idiosyncratic 700: 695: 690: 680: 677: 671: 669: 665: 660: 656: 652: 648: 644: 640: 636: 632: 627: 625: 621: 617: 613: 609: 605: 601: 597: 593: 589: 581: 577: 572: 567: 561: 551: 547: 545: 541: 537: 533: 529: 524: 521: 517: 513: 508: 504: 501: 500:meta-analytic 497: 486: 484: 478: 476: 472: 467: 463: 459: 455: 451: 447: 443: 439: 435: 431: 427: 423: 419: 418:psychosurgery 415: 411: 407: 403: 399: 398:psychotherapy 395: 390: 388: 384: 381:. The phrase 380: 376: 372: 368: 367:tic disorders 364: 360: 356: 352: 348: 344: 340: 336: 332: 328: 324: 320: 316: 312: 307: 305: 301: 297: 291: 289: 285: 281: 277: 273: 269: 265: 264:blasphemously 261: 257: 256:contamination 253: 249: 244: 242: 238: 234: 230: 227: 223: 219: 215: 206: 202: 199: 195: 191: 188: 184: 181: 177: 176:tic disorders 173: 169: 165: 163: 159: 155: 153: 149: 146: 142: 138: 134: 131: 129: 125: 121: 117: 114: 110: 106: 103: 101: 100:Complications 97: 94: 90: 86: 84: 80: 77: 74: 72: 68: 63: 59: 54: 49: 43: 39: 35: 30: 19: 15483:Technostress 15476:Technophobia 15471:Technophilia 15281: 15247:Evolutionary 15225:Evolutionary 15215:Neuroscience 15034:aripiprazole 15003:clomipramine 14957:escitalopram 14873:Superstition 14803: 14798:$ pringfield 14789: 14777: 14770: 14763: 14741: 14734: 14716: 14709: 14702: 14608:Aripiprazole 14590:Clomipramine 14524:Escitalopram 14283:Neuroanatomy 14245: 14075:Folie à deux 14000:Intoxication 13981:substances, 13979:Psychoactive 13898:Night terror 13715:Dissociative 13679:Panic attack 13673: 13231:Tic disorder 12926: 12915: 12891: 12880: 12869: 12854: 12839: 12824: 12789: 12751: 12692: 12688: 12678: 12643: 12639: 12629: 12620: 12614: 12581: 12577: 12571: 12538: 12534: 12528: 12516:. 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Retrieved 2952: 2892:Tic disorder 2832: 2817: 2808: 2793:Please help 2781: 2719: 2693: 2686: 2672:Charly Clive 2665: 2658: 2644: 2638:Marc Summers 2631: 2618: 2612:Nicolas Cage 2605: 2592: 2591:In the film 2583: 2573: 2540: 2532: 2524: 2521:James Spader 2518: 2511: 2500: 2493: 2487: 2472: 2462: 2455: 2449: 2444: 2432: 2415:clomipramine 2408: 2384: 2366:Pierre Janet 2357: 2353: 2346: 2344: 2313: 2307: 2298: 2282: 2268: 2256:scrupulosity 2238: 2229: 2158: <45 2128:Epidemiology 2115: 2106: 2102: 2085: 2073:brain tissue 2051: 2041: 2019:aripiprazole 1994: 1986:Clomipramine 1984: 1976: 1967: 1953:(SSRIs) and 1948: 1931: 1896: 1878: 1864: 1860: 1856: 1848: 1828: 1805: 1796: 1785: 1782:self-concept 1771: 1762: 1758: 1754: 1746: 1739: 1735: 1731: 1723: 1719: 1708: 1696:psychiatrist 1692:psychologist 1689: 1659: 1641:, decreased 1639:amphetamines 1616: 1583:serotonergic 1579: 1562: 1534: 1523: 1515: 1502:white matter 1474: 1423: 1393:, and right 1373:(OFC), left 1368: 1356:Neuroimaging 1332: 1320: 1301: 1269: 1249: 1242: 1235: 1231:case-control 1221:(SNPs) near 1212: 1189: 1174: 1170: 1155: 1147: 1144: 1140: 1137: 1134: 1130: 1114: 1064: 1059: 1055: 1033: 1021: 1010: 1006: 955: 943: 939: 935: 923: 894: 886:set-shifting 858: 849: 844: 832: 830: 814: 806: 794:onychophagia 790:skin picking 775: 767: 755: 743: 715:hair pulling 711:skin picking 703: 672: 655:heterosexual 628: 612:scrupulosity 585: 548: 525: 520:neuroimaging 509: 505: 492: 479: 462:clomipramine 458:escitalopram 391: 382: 308: 292: 272:hand washing 245: 240: 236: 217: 213: 212: 198:clomipramine 128:Risk factors 42: 29: 15429:Screen time 15046:risperidone 15024:haloperidol 14988:venlafaxine 14965:fluvoxamine 14805:Straight Up 14785:Adrian Monk 14772:The Aviator 14534:Fluvoxamine 14489:possessions 14440:Compulsions 14404:associative 14048:schizotypal 13883:Hypersomnia 13873:Nonorganic 13614:Agoraphobia 13345:Cyclothymia 13340:Bipolar NOS 13315:(affective) 13187:Stereotypic 13095:Kleptomania 12917:MedlinePlus 12746:‹ The 12466:27 February 12430:USA Network 12362:Almeida J. 12298:17 February 12263:11 November 11972:29 November 11674:: 185–189. 11242:(1): 7–26. 10901:(12): 103. 10448:(10): 920. 10175:: 167–173. 10136:(1): 3–13. 10109:29 February 9389:(8): e153. 8555:(1): 8–16. 7457:Menzies L, 7399:28 February 6928:: 377–412. 5639:11 December 5277:15 December 5094:: 131–148. 5041:: 156–159. 4984:30 December 4615:13 December 4611:(in Samoan) 4605:"About OCD" 4222:2066/247522 4205:: 302–312. 4070:: 233–242. 3905:11 December 2867:Cyclothymia 2746:lamotrigine 2699:hydrocodone 2625:Adrian Monk 2561:represents 2503:George Ezra 2495:The Aviator 2446:John Bunyan 2006:risperidone 1874:mindfulness 1837:(SSRIs) or 1787:egosyntonic 1778:egodystonic 1698:, clinical 1535:Due to the 1477:grey matter 1391:hippocampus 1335:bereavement 1329:Environment 1292:nerve cells 1279:subcortical 1079:cyclothymic 719:nail biting 683:Compulsions 643:intercourse 588:compulsions 542:(ADHD) and 528:homogeneous 446:fluvoxamine 379:suicidality 339:child abuse 304:egosyntonic 296:egodystonic 241:compulsions 141:temperament 119:Usual onset 15503:Categories 15362:Body image 15309:Depression 15263:Associated 15232:Psychology 15220:Psychiatry 15173:Ergonomics 15130:Nomophobia 15042:quetiapine 15038:olanzapine 14973:sertraline 14969:paroxetine 14961:fluoxetine 14953:citalopram 14728:Nonfiction 14689:Literature 14642:Behavioral 14572:Phenelzine 14554:Nefazodone 14549:Citalopram 14544:Sertraline 14539:Paroxetine 14529:Fluoxetine 14429:scrupulous 14419:pathogenic 14409:diagnostic 14400:Obsessions 14200:Stereotypy 14063:Delusional 14052:delusional 14025:Withdrawal 13893:Parasomnia 13798:Nosophobia 13578:Adjustment 13566:somatoform 13499:Sundowning 13352:Depression 13335:Bipolar II 13224:Stuttering 13219:Cluttering 13015:Paraphilia 12893:DiseasesDB 12440:8 December 12409:8 December 12378:14 January 12318:CharacTour 12258:Beyond OCD 11956:Penzel F. 11917:(11): 71. 11890:4 November 11115:(1): 186. 10878:30 January 10846:30 January 10202:Hayes SC. 10080:(2): 138. 9968:: 94–108. 9649:: 100709. 9534:12 October 8817:: 89–108. 8341:(Review). 8291:(Review). 8241:(Review). 7560:: 101298. 7513:: 101386. 7116:: 612586. 7036:30 October 6283:(1): 230. 5503:1874/11267 5176:: 98–113. 5010:4 February 4587:1993/30297 3784:. London: 3443:5 November 3371:6 November 3343:6 November 3307:6 November 2903:References 2756:See also: 2742:topiramate 2734:gabapentin 2715:paroxetine 2711:fluoxetine 2651:John Green 2649:(2017) by 2509:(Pure O). 2428:sertraline 2424:fluoxetine 2038:Procedures 2014:Quetiapine 2010:olanzapine 1963:fluoxetine 1959:Sertraline 1937:Medication 1927:decoupling 1870:acceptance 1809:(CBT) and 1802:Management 1792:self-image 1606:receptors 1542:cerebellar 1345:Mechanisms 1323:antibodies 1298:Autoimmune 1290:that some 1204:homozygous 1200:Caucasians 1093:, 12% for 1089:, 18% for 1081:traits or 1069:with both 1067:comorbidly 1052:motor tics 908:See also: 821:delusional 802:decoupling 763:dermatitis 731:perception 659:homosexual 616:Mysophobia 564:See also: 554:Obsessions 454:citalopram 450:paroxetine 442:fluoxetine 438:sertraline 226:behavioral 190:Counseling 76:Psychiatry 15242:Cognitive 14711:Plyushkin 14696:Fictional 14499:Treatment 14414:injurious 14319:Receptors 14153:Catatonia 14085:Psychosis 13920:Postnatal 13903:Nightmare 13509:Wandering 13362:Dysthymia 13330:Bipolar I 13285:Pervasive 13100:Pyromania 13025:Voyeurism 13020:Fetishism 12928:eMedicine 12711:1662-453X 12347:9 January 12240:145735144 12232:0163-9625 12080:9 January 12022:9 January 11381:CNS Drugs 11077:232408932 10962:205193449 10598:253347210 10345:248890026 10329:1423-0348 10248:713181786 10189:2211-3649 10055:211085261 10039:1091-4269 9998:220521468 9982:0165-0327 9736:143040967 9722:: 23–37. 9701:143731458 9663:245996392 9007:207442722 8839:206984783 8677:: 25–32. 8295:: 39–44. 8099:: 51–65. 7627:208214719 7535:218585620 7444:203833429 7012:146592937 6751:(1): 36. 6484:207639773 6366:: 13–29. 6157:: 24–36. 6122:: 48–58. 5845:: 66–71. 5791:0005-7967 5617:(1): 6–9. 5558:1554-4893 5465:31 August 5428:: 15–27. 5005:OCD Types 4369:220288984 3786:Routledge 3643:218772347 3087:0272-7358 2782:does not 2730:memantine 2722:glutamate 2695:μ-Opioids 2604:The film 2391:Vic Meyer 2358:obsession 2316:possessed 2289:Christian 2279:blasphemy 2252:describes 2248:historian 2122:remission 2112:Prognosis 1957:(SNRIs). 1852:habituate 1686:Diagnosis 1672:glutamate 1604:serotonin 1585:systems. 1566:Pavlovian 1446:precuneus 1284:serotonin 1240:and OCD. 1181:serotonin 1119:or other 1083:hypomanic 735:attention 341:or other 237:obsession 204:Frequency 186:Treatment 71:Specialty 15331:Insomnia 15237:Clinical 14718:Xenocide 14628:Inositol 14470:Hoarding 14444:impulses 14434:symmetry 14393:Symptoms 14351:μ Opioid 14294:striatum 13888:Insomnia 13558:Neurotic 13525:Delirium 13451:Dementia 13290:Specific 12748:template 12729:37274201 12720:10232807 12670:22024159 12606:35971588 12598:12783603 12563:30024004 12555:21352883 12461:Playbill 12403:Archived 12341:Archived 12100:BBC News 12074:Archived 12051:Archived 12016:Archived 11943:34613498 11772:(1950). 11688:25911133 11529:15 March 11509:30745684 11458:22275846 11401:23580175 11358:15533282 11323:19378573 11266:23746138 11184:Archived 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