30:
330:
and fluorine-containing analogs for 19F NMR-spectroscopy and protein folding studies. He was the first to demonstrate the use of genetic code engineering as a tool for the creation of therapeutic proteins and ribosomally synthesized peptide-drugs. He has succeeded with innovative engineering of
1013:
Baumann, T.; Hauf, M.; Schildhauer, F.; Eberl, K.; Durkin, P. M.; Deniz, E.; Löffler, J. G.; Acevedo-Rocha, C. G.; Jaric, J.; Martins, B. M.; Dobbek, H.; Bredenbeck, J.; Budisa, N. (2019). "Site-Resolved
Observation of Vibrational Energy Transfer Using a Genetically Encoded Ultrafast Heater".
871:
Exner, M. P.; Kuenzl, S.; Schwagerus, S.; To, T.; Ouyang, Z.; Hoesl, M. G.; Lensen, M. C.; Hackenberger, C. P. R.; Panke, S.; Budisa, N. (2017). "Design of an S-Allylcysteine in situ production and incorporation system based on a novel pyrrolysyl-tRNA synthetase variant".
404:. At the same time, this approach might be an interesting biosafety technology to evolve biocontained synthetic cells equipped with a "genetic firewall" which prevents their survival outside of man-made unnatural environments. Similar experiments with fluorinated
1092:
Budisa, N.; Steipe, B.; Demange, P.; Eckerskorn, C.; Kellermann, J.; Huber, R. (1995). "High level biosynthetic substitution of methionine in proteins by its analogues 2-aminohexanoic acid, selenomethionine, telluromethionine and ethionine in
Escherichia coli".
2015:
1253:
Hauf, M.; Richter, F.; Schneider, T.; Faidt, T.; Martins, B. M.; Baumann, T.; Durkin, P.; Dobbek, H.; Jacobs, K.; Moeglich, A.; Budisa, N. (2017). "Photoactivatable mussel-based underwater adhesive proteins by an expanded genetic code".
1834:
Agostini, F.; Sinn, L.; Petras, D.; Schipp, C. J.; Kubyshikin, V; Berger, A. A.; Dorrestein, P. C; Rappsilber, J.; Budisa, N.; Koksch, B. (2019). "Laboratory evolution of
Escherichia coli enables life based on fluorinated amino acids".
311:) as well as special spectroscopic features (e.g. blue and golden fluorescence or vibration energy transfer) into the proteins of living cells. In addition, his method allows the delivery of element-specific properties (
1423:
Doerfel, L. K.; Wohlgemuth, I.; Kubyshkin, V.; Starosta, A. L.; Wilson, D. N.; Budisa, N. (2015). "Entropic
Contribution of Elongation Factor P to Proline Positioning at the Catalytic Center of the Ribosome".
1128:
Seifert, M. H.; Ksiazek, D.; Smialowski, P.; Azim, M. K.; Budisa, N.; Holak, T. A. (2002). "Slow
Conformational Exchange Processes in Green Fluorescent Protein Variants evidenced by NMR Spectroscopy".
1165:"Residue specific bioincorporation of non-natural biologically active amino acids into proteins as possible drug carriers. Structure and stability of per-thiaproline mutant or annexin V"
2020:
223:
engineering. He is the author of the only textbook in his research field: âEngineering the genetic code: expanding the amino acid repertoire for the design of novel proteinsâ.
280:
384:
In 2015, the team led by Ned Budisa reported the successful completion of a long-term evolution experiment that resulted in full, proteome-wide substitution of all 20,899
1057:
Agostini, F.; Völler, J-S.; Koksch, B.; Acevedo-Rocha, C. G.; Kubyshkin, V.; Budisa, N. (2017). "Biocatalysis with
Unnatural Amino Acids: Enzymology Meets Xenobiology".
2035:
2065:
431:
Ned Budisa is also actively involved in the debate of possible societal, ethical and philosophical impacts of radical genetic code engineering in the context of
974:
Bae, J.; Rubini, M.; Jung, G.; Wiegand, G.; Seifert, M. H. J.; Azim, M. K.; Kim, J. S.; Zumbusch, A.; Holak, T. A.; Moroder, L.; Huber, R.; Budisa, N. (2003).
369:
was designed. Along with Budisa's previous work on bioexpression using proline analogues, the results of this project contributed to the establishment of the
730:
975:
781:"Sense codon emancipation for proteome-wide incorporation of noncanonical amino acids: rare isoleucine codon AUA as a target for genetic code expansion"
251:. He also habilitated at the Technical University of Munich in 2005 and worked afterwards as a junior group leader ("Molecular Biotechnology") at the
1742:"Alternative Biochemistries for Alien Life: Basic Concepts and Requirements for the Design of a Robust Biocontainment System in Genetic Isolation"
283:
that enables single and multiple in vivo incorporations of synthetic (i.e. non-canonical) amino acid analogs in proteins, preferably by sense
268:
2000:
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1925:
89:
68:
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Kubyshkin, V.; Budisa, N. (2017). "Synthetic alienation of microbial organisms by using genetic code engineering: Why and how?".
1799:
Acevedo-Rocha, C. G.; Budisa, N. (2011). "On the Road towards
Chemically Modified Organisms Endowed with a Genetic Firewall".
259:
at the TU Berlin in 2010 until the end of 2018, when he accepted the Tier 1 CRC position in
Chemical Synthetic Biology at the
1873:
326:
Ned Budisa is well known for the establishment of the use of selenium-containing non-canonical amino acids for protein X-ray
252:
744:
Lepthien, S.; Merkel, L.; Budisa, N. (2010). "In Vivo Double and Triple
Labeling of Proteins Using Synthetic Amino Acids".
299:. These experiments are often assisted with simple metabolic engineering. Ned's research goal is the transfer of various
1951:
703:
Budisa, N. (2004). "Prolegomena to future efforts on genetic code engineering by expanding its amino acid repertoire".
492:
401:
571:
555:
1299:"Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein"
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Völler, J.-S.; Budisa, N. (2017). "Coupling genetic code expansion and metabolic engineering for synthetic cells".
639:
124:
35:
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1995:
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263:. Ned Budisa is also a member of the Excellence Cluster âUnifying Systems in Catalysisâ (UniSysCat) and keeps
2045:
1467:
Kubyshkin, V.; Grage, S. L.; BĂŒrck, J.; Ulrich, A. S.; Budisa, N. (2018). "Transmembrane
Polyproline Helix".
64:
2080:
255:
in Munich. Between 2007 and 2010 he was a member of CIPS in Munich. He was appointed as full professor of
413:
1911:
976:"Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins"
378:
2005:
1594:"The Alanine World Model for the Development of the Amino Acid Repertoire in Protein Biosynthesis"
1214:
Budisa, N. (2013). "Expanded genetic code for the engineering of ribosomally synthetized [
287:. His methodology allows for fine chemical manipulations of the amino acid side chains, mainly of
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304:
416:) has led to the discovery of exceptional physiological plasticity in microbial cultures during
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Ned Budisa earned a High school teacher diploma in Chemistry and Biology in 1990, a B.S. in
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1504:"Anticipating alien cells with alternative genetic codes: away from the alanine world!"
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1358:"Synthetic Biology of Proteins: Tuning GFPÂŽs Folding and Stability with Fluoroproline"
1297:
Wolschner, C.; Giese, A.; Kretzschmar, H.; Huber, R.; Moroder, L.; Budisa, N. (2009).
991:
159:; born 21 November 1966) is a Croatian biochemist, professor and holder of the Tier 1
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396:. This is a solid basis for the evolution of life with alternative building blocks,
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Budisa, N.; Minks, C.; Medrano, F. J.; Lutz, J.; Huber, R.; Moroder, L. (1998).
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Xenobiology: State-of-the-art, Ethics and Philosophy of new-to-nature organisms
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Together with his co-worker Vladimir Kubyshkin, the new-to-nature hydrophobic
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339:. Ned Budisa made seminal contributions to our understanding of the role of
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1218:] and post-translationally modified peptide natural products (RiPPs)".
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Hoesl, M. G.; Oehm, S.; Durkin, P.; Darmon, E.; Peil, L.; Aerni, H.-R.;
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2001:
Genetic Code 2.0 â 3 Synthetic Amino Acids Combined Into One Protein
1841:
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Steiner, T.; Hess, P.; Bae, J. H.; Moroder, L.; Budisa, N. (2008).
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2006:
Oxidation sets off fatal structural change of human prion proteins
1422:
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288:
917:"Azatryptophans endow proteins with intrinsic blue fluorescence"
424:, making them potential environmentally friendly tools for new
79:
2010:
1985:
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status at the TU Berlin. In 2014, he founded the first Berlin
1091:
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915:
Lepthien, S.; Hoesl, M. G.; Merkel, L.; Budisa, N. (2008).
661:
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914:
335:, in particular photoactivatable mussel-based underwater
1833:
1655:; Rinehart, J.; Leach, D.; Söll, D.; Budisa, N. (2015).
1551:
Kubyshkin, V.; Acevedo-Rocha, C. G.; Budisa, N. (2017).
870:
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compounds (in collaboration with Beate Koksch from the
1162:
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183:), his research has a wide range of applications in
1798:
226:
1553:"On universal coding events in protein biogenesis"
729:: CS1 maint: DOI inactive as of September 2024 (
2027:
1855:
442:
2066:Faculty of Science, University of Zagreb alumni
2036:Academic staff of Technische UniversitÀt Berlin
1952:"UniCat â Publication Award Fluorine Chemistry"
1704:
1591:
1501:
2021:A Super Adhesive Made from Intestinal Bacteria
2016:Professor and hobby boxer (article in german)
640:"University of Manitoba welcoming Ned Budisa"
381:amino acids for ribosomal protein synthesis.
281:Selective Pressure Incorporation (SPI) method
1657:"Chemical evolution of a bacterial proteome"
835:
778:
347:aggregation and has discovered the roles of
307:reactions (chemoselective ligations such as
1991:General talk about Genetic Code Engineering
388:residues with thienopyrrole-alanine in the
1739:
451:2017: Publication Award Fluorine Chemistry
1856:Schmidt, M.; Pei, L.; Budisa, N. (2018).
1840:
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439:as well as technologies derived thereof.
90:Faculty of Science, University of Zagreb
1801:Angewandte Chemie International Edition
1661:Angewandte Chemie International Edition
1059:Angewandte Chemie International Edition
1016:Angewandte Chemie International Edition
746:Angewandte Chemie International Edition
705:Angewandte Chemie International Edition
247:where his thesis advisor was Professor
2028:
1213:
702:
574:. Max Planck Institute. Archived from
537:
359:, folding and stability of proteins.
253:Max Planck Institute for Biochemistry
243:. He received a PhD in 1997 from the
1986:Talk about the future of Xenobiology
540:The book at the Wiley Online Library
1996:Built-in drugs could target tissues
1860:. Vol. 162. pp. 301â315.
619:"Website of the Biocatalysis group"
373:. It explains why nature chose the
13:
1592:Kubyshkin, V.; Budisa, N. (2019).
1502:Kubyshkin, V.; Budisa, N. (2019).
493:Central dogma of molecular biology
14:
2097:
1969:
662:"UniSysCat Cluster of Excellence"
323:) into the biochemistry of life.
2056:21st-century Croatian scientists
1570:10.1016/j.biosystems.2017.10.004
1508:Current Opinion in Biotechnology
1220:Current Opinion in Biotechnology
1107:10.1111/j.1432-1033.1995.0788h.x
838:Current Opinion in Biotechnology
227:Early life, education and career
28:
1944:
1918:
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1207:
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1085:
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967:
908:
864:
829:
779:Bohlke, N.; Budisa, N. (2014).
772:
2071:Scientists from Split, Croatia
1446:11858/00-001M-0000-0028-E3C7-1
737:
719:(inactive September 19, 2024).
696:
675:
654:
632:
611:
590:
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245:Technical University of Munich
1:
1740:Diwo, C.; Budisa, N. (2019).
992:10.1016/s0022-2836(03)00364-4
524:
443:Awards and honors (selection)
171:. As pioneer in the areas of
125:Technische UniversitÀt Berlin
1521:10.1016/j.copbio.2019.05.006
1383:10.1371/journal.pone.0001680
1232:10.1016/j.copbio.2013.02.026
980:Journal of Molecular Biology
850:10.1016/j.copbio.2017.02.002
7:
2011:iGEM.Berlin Magnetic e.Coli
1481:10.1021/acs.jpclett.8b00829
455:
274:
10:
2102:
1303:Proc. Natl. Acad. Sci. USA
1169:Proc. Natl. Acad. Sci. USA
921:Proc. Natl. Acad. Sci. USA
351:side chain conformations (
1976:Homepage of the TU Berlin
1926:"BioFuture Award profile"
785:FEMS Microbiology Letters
598:"List of CIPS professors"
572:"Molecular Biotechnology"
538:Budisa, Nediljko (2005).
414:Free University of Berlin
191:in general. Being highly
175:engineering and chemical
134:
120:
102:
95:
85:
75:
43:
27:
20:
371:Alanine World hypothesis
1324:10.1073/pnas.0902688106
942:10.1073/pnas.0802804105
797:10.1111/1574-6968.12371
473:Bioorthogonal chemistry
305:bioorthogonal chemistry
279:Ned Budisa applies the
2051:Scientists from Zagreb
1813:10.1002/anie.201103010
1719:10.1002/biot.201600097
1673:10.1002/anie.201502868
1268:10.1002/cbic.201700327
1071:10.1002/anie.201610129
1028:10.1002/anie.201812995
886:10.1002/cbic.201600537
758:10.1002/anie.201000439
261:University of Manitoba
169:University of Manitoba
156:
129:University of Manitoba
2041:20th-century chemists
1759:10.3390/genes10010017
1707:Biotechnology Journal
1182:10.1073/pnas.95.2.455
717:10.1002/anie.20030064
503:Expanded genetic code
448:2004: BioFuture Award
161:Canada Research Chair
22:Nediljko "Ned" Budisa
2046:Croatian biochemists
1695:NIHMSID: NIHMS711205
1611:10.3390/ijms20215507
1438:10.1021/jacs.5b07427
364:polyproline-II helix
341:methionine oxidation
241:University of Zagreb
111:bioorganic chemistry
2076:People from Ć ibenik
1667:(34): 10030â10034.
1469:J. Phys. Chem. Lett
1432:(40): 12997â13006.
1374:2008PLoSO...3.1680S
1315:2009PNAS..106.7756W
933:2008PNAS..10516095L
927:(42): 16095â16100.
189:engineering biology
163:(CRC) for chemical
1866:10.1007/10_2016_14
683:"iGEM team Berlin"
642:. October 16, 2018
548:10.1002/3527607188
498:Directed evolution
353:endo-exo isomerism
285:codon reassignment
205:structural biology
38:Laboratory in 2012
2081:People from DrniĆĄ
1875:978-3-319-55317-7
1807:(31): 6960â6962.
1309:(19): 7756â7761.
1262:(18): 1819â1823.
1142:10.1021/ja0257725
1136:(27): 7932â7942.
1065:(33): 9680â9703.
752:(32): 5446â5450.
392:of the bacterium
265:adjunct professor
239:in 1993 from the
233:Molecular Biology
201:medical chemistry
193:interdisciplinary
177:synthetic biology
165:synthetic biology
138:
137:
115:synthetic biology
97:Scientific career
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1963:
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1932:on June 30, 2007
1928:. Archived from
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1598:Int. J. Mol. Sci
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1475:(9): 2170â2174.
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1426:J. Am. Chem. Soc
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1130:J. Am. Chem. Soc
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1022:(9): 2527â2903.
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912:
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583:
578:on June 10, 2007
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562:
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394:Escherichia coli
57:
54:21 November 1966
53:
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32:
18:
17:
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1126:
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1095:Eur. J. Biochem
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1007:
986:(5): 977â1202.
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433:synthetic cells
377:with "only" 20
328:crystallography
309:click chemistry
303:properties and
301:physicochemical
277:
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157:Nediljko BudiĆĄa
86:Alma mater
71:
58:
55:
49:
47:
39:
23:
12:
11:
5:
2099:
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2018:
2013:
2008:
2003:
1998:
1993:
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1983:
1981:UniCat profile
1978:
1971:
1970:External links
1968:
1965:
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1943:
1917:
1908:|journal=
1874:
1848:
1842:10.1101/665950
1826:
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1713:(8): 1600097.
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1653:Rappsilber, J.
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1459:
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1348:
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1226:(4): 591â598.
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468:Biocontainment
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463:Bioconjugation
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