217:
cell contraction. This reaction prevents disengaged cells that are adjacent to one another from reestablishing connections, thus contributing to the maintenance of the gaps between cells. With their strong ability to cross the plasma membrane with little resistance from the cell, along with their specificity for a single target-substrate, MLCK inhibitors can potentially evolve into novel
22:
252:
A novel mechanism of activated T cell recruitment into inflammatory tissues has been proposed, known was "CD69/Myl9/12 system". The proposed mechanism state that "Myl9/12-containing net-like structures are created in inflammatory vessels, which play an important role as a platform for recruitment of
216:
Myosin light chain kinase (MLCK) inhibitors are one of the few peptides that can cross the plasma membrane relatively quickly. Under stressful conditions, MLCK's in the human body promotes increased permeability of microvessels. It is thought that MLCK phosphorylates endothelial myosin, leading to
207:
One study, published in 2012, found that valvular myosin 'LC1', in the hearts of three patients with valvular heart diseases, had structures similar to those of valvular myosin of people who were in their early stages of DCMP and HCMP. The researchers hypothesized that the structure distortion of
81:
MLCs are structurally and functionally distinct from myosin heavy chains (MHCs). Nevertheless, the association of MLCs with the neck region of MHCs is necessary for the assembly of the macromolecular complexes that result in the functional motor protein, myosin. The interaction of MLCs with the
77:
Essential and regulatory MLCs have molecular masses of 22 and 19 kDa, respectively. Structurally, MLC2 contains a serine residue that is lacking in MLC1. The presence of this amino acids allows the regulation of the conformational changes (from compacted to an elongated form) by a Ca-mediated
195:
Several diseases have been associated with mutations in the genes encoding for myosin light chain proteins. The majority of these diseases are cardiomyopathies, such as hypertrophic (HCM) or dilated (DCM) cardiomyopathy and sudden cardiac death. Mutations in
253:
CD69-expressing leukocytes into inflammatory tissues. T cells that are activated in the lymph nodes proliferate, down-regulate CD69 expression, and then leave the lymph nodes to migrate into inflammatory sites in an S1PR1-dependent manner."
562:
Hayashizaki K, Kimura MY, Tokoyoda K, Hosokawa H, Shinoda K, Hirahara K, Ichikawa T, Onodera A, Hanazawa A, Iwamura C, Kakuta J, Muramoto K, Motohashi S, Tumes DJ, Iinuma T, Yamamoto H, Ikehara Y, Okamoto Y, Nakayama T (September 2016).
62:
Structurally, myosin light chains belong to the EF-hand family, a large family of Ca- binding proteins. MLCs contain two Ca - binding EF-hand motifs. MLCs isoforms modulate the Caof force transduction and cross-bridge kinetics.
518:
Lukas, T. J.; Mirzoeva, S.; Slomczynska, U.; Watterson, D. M. (11 March 1999). "Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge".
256:
The proposed mechanisms of action of CD69/Myl9/12 system are related to the regulation of airway inflammatory processes and thus can prove to be a novel therapeutic target for chronic inflammatory diseases, in general.
610:
Kimura MY, Hayashizaki K, Tokoyoda K, Takamura S, Motohashi S, Nakayama T (July 2017). "Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation".
90:
To this day, eight genes encoding for MLCs in mammalians have been described; several isoforms have also been characterized. Four out of the 8 genes are MLC1 genes, whilst the remaining are MLC2 genes.
457:
25:
Part of the myosin II structure. Atoms in the heavy chain are colored red on the left-hand side, and atoms in the light chains are colored orange and yellow.
672:
78:
phosphorylation mechanism. MLC1, in contrast with MLC2, has a N-terminal sequence able to bind actin, contributing to force production.
2481:
2501:
2433:
2418:
2413:
2408:
2403:
2393:
2314:
2023:
2003:
1973:
1968:
2643:
2638:
2633:
2628:
2383:
2373:
2363:
2358:
2329:
2033:
2028:
1075:
963:
953:
928:
908:
812:
792:
1035:
147:
1300:
208:
these valvular myosin were due to adaptational changes by the body in an attempt to improve the functioning of the heart.
665:
1819:
2088:
1931:
658:
271:
2967:
2521:
1228:
2699:
266:
171:
Other proteins and enzymes related to MLC function have been described. Among them are, for example,
504:
2932:
294:
2987:
46:
565:"Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation"
410:"Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations"
290:
1351:
705:
491:
1620:
8:
2927:
1560:
564:
1380:
636:
592:
472:
434:
409:
385:
360:
336:
311:
2778:
1142:
628:
584:
544:
536:
439:
390:
341:
596:
476:
2726:
1850:
1205:
1200:
640:
620:
576:
528:
464:
429:
421:
380:
372:
331:
323:
2868:
1482:
1332:
1215:
2831:
2694:
1391:
1222:
731:
650:
580:
307:
468:
425:
376:
327:
2981:
2895:
2890:
1855:
1725:
1674:
1624:
1564:
1486:
1454:
1395:
1181:
700:
540:
2739:
1794:
1549:
1093:
685:
632:
588:
548:
443:
394:
345:
2711:
2689:
2885:
2836:
2706:
2596:
1926:
1370:
1325:
1244:
1166:
714:
42:
34:
2937:
2856:
2846:
2734:
1845:
1824:
1590:
1527:
1522:
1517:
1497:
1472:
1460:
1446:
1441:
1436:
1431:
1426:
1421:
1416:
1411:
1406:
1268:
1150:
1139:
1125:
741:
624:
532:
66:
Myosin light chains (MLCs) can be broadly classified into two groups:
2766:
2761:
2756:
2716:
2554:
2549:
2544:
1902:
1882:
1537:
1532:
1512:
1507:
1502:
1492:
1401:
1305:
1239:
2880:
2841:
2773:
2746:
2613:
2601:
2476:
2471:
1912:
1907:
1829:
1263:
1258:
1120:
2907:
2861:
2751:
2681:
2650:
2580:
2575:
2539:
2534:
2529:
2496:
2466:
2461:
2456:
2451:
2136:
2068:
2063:
2058:
2053:
2048:
1940:
1877:
1365:
1310:
1251:
1234:
1195:
681:
609:
561:
517:
361:"Heavy and light roles: myosin in the morphogenesis of the heart"
245:
have been described as new functional interaction partners with
2826:
2808:
2803:
2798:
2793:
2783:
2618:
2511:
2506:
2491:
2486:
2398:
2344:
2309:
2284:
2279:
2274:
2269:
2259:
2254:
2244:
2229:
2224:
2106:
2101:
2096:
2008:
1998:
1978:
1963:
1958:
1953:
1948:
1814:
1585:
1580:
1337:
1003:
998:
988:
766:
240:
224:
130:(chromosome 12q13.2); expressed in non-muscle and smooth muscle
82:α-helical neck region of MHC molecule stabilizes the complex .
38:
2851:
2623:
2606:
2443:
2438:
2428:
2423:
2388:
2378:
2368:
2353:
2334:
2324:
2319:
2304:
2299:
2294:
2289:
2264:
2249:
2239:
2234:
2219:
2214:
2194:
2189:
2184:
2179:
2174:
2169:
2164:
2159:
2154:
2149:
2144:
2116:
2111:
2078:
2073:
2043:
2038:
2018:
2013:
1993:
1983:
1898:
1776:
1771:
1766:
1761:
1756:
1751:
1746:
1741:
1736:
1731:
1715:
1710:
1705:
1700:
1695:
1690:
1685:
1680:
1655:
1650:
1645:
1640:
1635:
1630:
1610:
1605:
1600:
1595:
1575:
1570:
1280:
1210:
1159:
1156:
1153:
1145:
1134:
1131:
1128:
1113:
1108:
1103:
1098:
1070:
1060:
1045:
978:
968:
948:
923:
918:
903:
893:
888:
883:
878:
873:
868:
853:
807:
802:
797:
787:
782:
777:
756:
751:
746:
736:
723:
218:
184:
176:
172:
41:. Myosin light chains were discovered by Chinese biochemist
2952:
2947:
2942:
2902:
2873:
2788:
2665:
2660:
2655:
2559:
2209:
2204:
2199:
2126:
2121:
1988:
1870:
1865:
1860:
1320:
1315:
1273:
1186:
1176:
1171:
1065:
1055:
1050:
1040:
1030:
1025:
1020:
1015:
938:
863:
858:
848:
843:
838:
833:
828:
823:
246:
230:
180:
163:
155:
139:
126:
118:
110:
99:
21:
45:(Tien-chin Tsao) when he was a graduate student at the
407:
312:"In memory of Professor Tianqin Cao (Tien-chin Tsao)"
249:
in the pathogenesis of inflammation of the airways.
122:(chromosome 17q21.32); expressed in striated muscle
167:(chromosome 20q11.23); expressed in smooth muscle
114:(chromosome 3p21.3); expressed in striated muscle
106:chromosome 2q24.11); expressed in striated muscle
2979:
680:
190:
358:
666:
408:Huang W, Szczesna-Cordary D (December 2015).
143:(chromosome 12q24.11); found in the sarcomere
57:
458:"Databases Login | Hunter College Libraries"
414:Journal of Muscle Research and Cell Motility
225:Interaction of MLCs with non-myosin proteins
211:
159:(chromosome 12q13.2); found in the sarcomere
151:(chromosome 4p16.3); found in the sarcomere
673:
659:
433:
384:
335:
293:at the U.S. National Library of Medicine
52:
20:
204:have been reported for these diseases.
2980:
85:
70:Essential or alkali MLC (MLC1 or ELC),
654:
306:
365:Cellular and Molecular Life Sciences
359:England J, Loughna S (April 2013).
16:Small polypeptide subunit of myosin
13:
14:
2999:
450:
1301:Wiskott–Aldrich syndrome protein
2522:Microtubule organising proteins
603:
555:
521:Journal of Medicinal Chemistry
511:
401:
352:
300:
284:
272:Myosin-light-chain phosphatase
1:
2569:Microtubule severing proteins
277:
191:Diseases associated with MLCs
73:Regulatory MLC (MLC2 or RLC).
1229:actin depolymerizing factors
7:
2707:Plakoglobin (gamma catenin)
260:
10:
3004:
581:10.1126/sciimmunol.aaf9154
58:Myosin light chain classes
2963:
2920:
2819:
2725:
2680:
2589:
2568:
2520:
2343:
2135:
2087:
1939:
1925:
1891:
1838:
1807:
1787:
1666:
1548:
1379:
1361:
1350:
1293:
1086:
765:
722:
713:
699:
692:
469:10.1134/S0006350912020194
426:10.1007/s10974-015-9423-3
377:10.1007/s00018-012-1131-1
328:10.1007/s13238-010-0074-2
267:Myosin light-chain kinase
212:MLCKs as Biological Drugs
2933:Prokaryotic cytoskeleton
295:Medical Subject Headings
33:is a light chain (small
47:University of Cambridge
499:Cite journal requires
53:Structure and function
26:
1553:(hard alpha-keratins)
1384:(soft alpha-keratins)
613:Immunological Reviews
24:
2968:cytoskeletal defects
2928:Major sperm proteins
1381:Epithelial keratins
291:Myosin+Light+Chains
86:Genes in mammalians
569:Science Immunology
316:Protein & Cell
31:myosin light chain
27:
2975:
2974:
2916:
2915:
2676:
2675:
1921:
1920:
1803:
1802:
1346:
1345:
1289:
1288:
625:10.1111/imr.12559
533:10.1021/jm980573a
2995:
1937:
1936:
1377:
1376:
1359:
1358:
720:
719:
711:
710:
697:
696:
675:
668:
661:
652:
651:
645:
644:
607:
601:
600:
559:
553:
552:
515:
509:
508:
502:
497:
495:
487:
485:
483:
462:
454:
448:
447:
437:
405:
399:
398:
388:
356:
350:
349:
339:
304:
298:
288:
3003:
3002:
2998:
2997:
2996:
2994:
2993:
2992:
2978:
2977:
2976:
2971:
2959:
2912:
2815:
2721:
2672:
2585:
2564:
2516:
2339:
2131:
2083:
1929:
1917:
1887:
1834:
1799:
1783:
1667:Ungrouped alpha
1662:
1552:
1544:
1383:
1369:
1363:
1353:
1342:
1285:
1082:
761:
703:
688:
679:
649:
648:
608:
604:
575:(3): eaaf9154.
560:
556:
516:
512:
500:
498:
489:
488:
481:
479:
460:
456:
455:
451:
406:
402:
357:
353:
305:
301:
289:
285:
280:
263:
227:
214:
193:
88:
60:
55:
17:
12:
11:
5:
3001:
2991:
2990:
2988:Motor proteins
2973:
2972:
2964:
2961:
2960:
2958:
2957:
2956:
2955:
2950:
2945:
2940:
2930:
2924:
2922:
2918:
2917:
2914:
2913:
2911:
2910:
2905:
2900:
2899:
2898:
2893:
2883:
2878:
2877:
2876:
2866:
2865:
2864:
2859:
2854:
2849:
2844:
2839:
2834:
2832:Corneodesmosin
2823:
2821:
2817:
2816:
2814:
2813:
2812:
2811:
2806:
2801:
2796:
2791:
2786:
2781:
2771:
2770:
2769:
2764:
2759:
2749:
2744:
2743:
2742:
2731:
2729:
2723:
2722:
2720:
2719:
2714:
2709:
2704:
2703:
2702:
2692:
2686:
2684:
2678:
2677:
2674:
2673:
2671:
2670:
2669:
2668:
2663:
2658:
2648:
2647:
2646:
2641:
2636:
2631:
2626:
2616:
2611:
2610:
2609:
2599:
2593:
2591:
2587:
2586:
2584:
2583:
2578:
2572:
2570:
2566:
2565:
2563:
2562:
2557:
2552:
2547:
2542:
2537:
2532:
2526:
2524:
2518:
2517:
2515:
2514:
2509:
2504:
2499:
2494:
2489:
2484:
2479:
2474:
2469:
2464:
2459:
2454:
2447:
2446:
2441:
2436:
2431:
2426:
2421:
2416:
2411:
2406:
2401:
2396:
2391:
2386:
2381:
2376:
2371:
2366:
2361:
2356:
2349:
2347:
2341:
2340:
2338:
2337:
2332:
2327:
2322:
2317:
2312:
2307:
2302:
2297:
2292:
2287:
2282:
2277:
2272:
2267:
2262:
2257:
2252:
2247:
2242:
2237:
2232:
2227:
2222:
2217:
2212:
2207:
2202:
2197:
2192:
2187:
2182:
2177:
2172:
2167:
2162:
2157:
2152:
2147:
2141:
2139:
2133:
2132:
2130:
2129:
2124:
2119:
2114:
2109:
2104:
2099:
2093:
2091:
2085:
2084:
2082:
2081:
2076:
2071:
2066:
2061:
2056:
2051:
2046:
2041:
2036:
2031:
2026:
2021:
2016:
2011:
2006:
2001:
1996:
1991:
1986:
1981:
1976:
1971:
1966:
1961:
1956:
1951:
1945:
1943:
1934:
1923:
1922:
1919:
1918:
1916:
1915:
1910:
1905:
1899:Nuclear lamins
1895:
1893:
1889:
1888:
1886:
1885:
1880:
1875:
1874:
1873:
1868:
1863:
1853:
1848:
1842:
1840:
1836:
1835:
1833:
1832:
1827:
1822:
1817:
1811:
1809:
1805:
1804:
1801:
1800:
1798:
1797:
1791:
1789:
1785:
1784:
1782:
1781:
1780:
1779:
1774:
1769:
1764:
1759:
1754:
1749:
1744:
1739:
1734:
1721:
1720:
1719:
1718:
1713:
1708:
1703:
1698:
1693:
1688:
1683:
1670:
1668:
1664:
1663:
1661:
1660:
1659:
1658:
1653:
1648:
1643:
1638:
1633:
1616:
1615:
1614:
1613:
1608:
1603:
1598:
1593:
1588:
1583:
1578:
1573:
1556:
1554:
1546:
1545:
1543:
1542:
1541:
1540:
1535:
1530:
1525:
1520:
1515:
1510:
1505:
1500:
1495:
1478:
1477:
1476:
1475:
1465:
1464:
1463:
1451:
1450:
1449:
1444:
1439:
1434:
1429:
1424:
1419:
1414:
1409:
1404:
1387:
1385:
1374:
1356:
1348:
1347:
1344:
1343:
1341:
1340:
1335:
1330:
1329:
1328:
1323:
1318:
1308:
1303:
1297:
1295:
1291:
1290:
1287:
1286:
1284:
1283:
1278:
1277:
1276:
1271:
1261:
1256:
1255:
1254:
1249:
1248:
1247:
1242:
1225:
1223:Arp2/3 complex
1220:
1219:
1218:
1213:
1208:
1203:
1192:
1191:
1190:
1189:
1184:
1179:
1174:
1164:
1163:
1162:
1148:
1137:
1118:
1117:
1116:
1111:
1106:
1101:
1090:
1088:
1084:
1083:
1081:
1080:
1079:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1008:
1007:
1006:
1001:
993:
992:
991:
983:
982:
981:
973:
972:
971:
966:
958:
957:
956:
951:
943:
942:
941:
933:
932:
931:
926:
921:
913:
912:
911:
906:
898:
897:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
818:
817:
816:
810:
805:
800:
795:
790:
785:
780:
771:
769:
763:
762:
760:
759:
754:
749:
744:
739:
734:
728:
726:
717:
708:
701:Microfilaments
694:
690:
689:
678:
677:
670:
663:
655:
647:
646:
602:
554:
527:(5): 910–919.
510:
501:|journal=
449:
400:
371:(7): 1221–39.
351:
299:
282:
281:
279:
276:
275:
274:
269:
262:
259:
226:
223:
213:
210:
192:
189:
169:
168:
160:
152:
144:
132:
131:
123:
115:
107:
87:
84:
75:
74:
71:
59:
56:
54:
51:
15:
9:
6:
4:
3:
2:
3000:
2989:
2986:
2985:
2983:
2970:
2969:
2962:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2935:
2934:
2931:
2929:
2926:
2925:
2923:
2919:
2909:
2906:
2904:
2901:
2897:
2894:
2892:
2889:
2888:
2887:
2884:
2882:
2879:
2875:
2872:
2871:
2870:
2867:
2863:
2860:
2858:
2855:
2853:
2850:
2848:
2845:
2843:
2840:
2838:
2835:
2833:
2830:
2829:
2828:
2825:
2824:
2822:
2818:
2810:
2807:
2805:
2802:
2800:
2797:
2795:
2792:
2790:
2787:
2785:
2782:
2780:
2777:
2776:
2775:
2772:
2768:
2765:
2763:
2760:
2758:
2755:
2754:
2753:
2750:
2748:
2745:
2741:
2738:
2737:
2736:
2733:
2732:
2730:
2728:
2724:
2718:
2715:
2713:
2712:Delta catenin
2710:
2708:
2705:
2701:
2698:
2697:
2696:
2693:
2691:
2690:Alpha catenin
2688:
2687:
2685:
2683:
2679:
2667:
2664:
2662:
2659:
2657:
2654:
2653:
2652:
2649:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2625:
2622:
2621:
2620:
2617:
2615:
2612:
2608:
2605:
2604:
2603:
2600:
2598:
2595:
2594:
2592:
2588:
2582:
2579:
2577:
2574:
2573:
2571:
2567:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2527:
2525:
2523:
2519:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2463:
2460:
2458:
2455:
2453:
2450:cytoplasmic:
2449:
2448:
2445:
2442:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2380:
2377:
2375:
2372:
2370:
2367:
2365:
2362:
2360:
2357:
2355:
2351:
2350:
2348:
2346:
2342:
2336:
2333:
2331:
2328:
2326:
2323:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2303:
2301:
2298:
2296:
2293:
2291:
2288:
2286:
2283:
2281:
2278:
2276:
2273:
2271:
2268:
2266:
2263:
2261:
2258:
2256:
2253:
2251:
2248:
2246:
2243:
2241:
2238:
2236:
2233:
2231:
2228:
2226:
2223:
2221:
2218:
2216:
2213:
2211:
2208:
2206:
2203:
2201:
2198:
2196:
2193:
2191:
2188:
2186:
2183:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2163:
2161:
2158:
2156:
2153:
2151:
2148:
2146:
2143:
2142:
2140:
2138:
2134:
2128:
2125:
2123:
2120:
2118:
2115:
2113:
2110:
2108:
2105:
2103:
2100:
2098:
2095:
2094:
2092:
2090:
2086:
2080:
2077:
2075:
2072:
2070:
2067:
2065:
2062:
2060:
2057:
2055:
2052:
2050:
2047:
2045:
2042:
2040:
2037:
2035:
2032:
2030:
2027:
2025:
2022:
2020:
2017:
2015:
2012:
2010:
2007:
2005:
2002:
2000:
1997:
1995:
1992:
1990:
1987:
1985:
1982:
1980:
1977:
1975:
1972:
1970:
1967:
1965:
1962:
1960:
1957:
1955:
1952:
1950:
1947:
1946:
1944:
1942:
1938:
1935:
1933:
1928:
1924:
1914:
1911:
1909:
1906:
1904:
1900:
1897:
1896:
1894:
1890:
1884:
1881:
1879:
1876:
1872:
1869:
1867:
1864:
1862:
1859:
1858:
1857:
1856:Neurofilament
1854:
1852:
1849:
1847:
1844:
1843:
1841:
1837:
1831:
1828:
1826:
1823:
1821:
1818:
1816:
1813:
1812:
1810:
1806:
1796:
1793:
1792:
1790:
1786:
1778:
1775:
1773:
1770:
1768:
1765:
1763:
1760:
1758:
1755:
1753:
1750:
1748:
1745:
1743:
1740:
1738:
1735:
1733:
1730:
1729:
1728:
1727:
1726:chromosome 12
1723:
1722:
1717:
1714:
1712:
1709:
1707:
1704:
1702:
1699:
1697:
1694:
1692:
1689:
1687:
1684:
1682:
1679:
1678:
1677:
1676:
1675:chromosome 17
1672:
1671:
1669:
1665:
1657:
1654:
1652:
1649:
1647:
1644:
1642:
1639:
1637:
1634:
1632:
1629:
1628:
1627:
1626:
1625:chromosome 12
1622:
1618:
1617:
1612:
1609:
1607:
1604:
1602:
1599:
1597:
1594:
1592:
1589:
1587:
1584:
1582:
1579:
1577:
1574:
1572:
1569:
1568:
1567:
1566:
1565:chromosome 17
1562:
1558:
1557:
1555:
1551:
1550:Hair keratins
1547:
1539:
1536:
1534:
1531:
1529:
1526:
1524:
1521:
1519:
1516:
1514:
1511:
1509:
1506:
1504:
1501:
1499:
1496:
1494:
1491:
1490:
1489:
1488:
1487:chromosome 12
1484:
1480:
1479:
1474:
1471:
1470:
1469:
1466:
1462:
1459:
1458:
1457:
1456:
1455:chromosome 12
1452:
1448:
1445:
1443:
1440:
1438:
1435:
1433:
1430:
1428:
1425:
1423:
1420:
1418:
1415:
1413:
1410:
1408:
1405:
1403:
1400:
1399:
1398:
1397:
1396:chromosome 17
1393:
1389:
1388:
1386:
1382:
1378:
1375:
1372:
1367:
1360:
1357:
1355:
1352:Intermediate
1349:
1339:
1336:
1334:
1331:
1327:
1324:
1322:
1319:
1317:
1314:
1313:
1312:
1309:
1307:
1304:
1302:
1299:
1298:
1296:
1292:
1282:
1279:
1275:
1272:
1270:
1267:
1266:
1265:
1262:
1260:
1257:
1253:
1250:
1246:
1243:
1241:
1238:
1237:
1236:
1233:
1232:
1231:
1230:
1226:
1224:
1221:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1198:
1197:
1194:
1193:
1188:
1185:
1183:
1180:
1178:
1175:
1173:
1170:
1169:
1168:
1165:
1161:
1158:
1155:
1152:
1149:
1147:
1144:
1141:
1138:
1136:
1133:
1130:
1127:
1124:
1123:
1122:
1119:
1115:
1112:
1110:
1107:
1105:
1102:
1100:
1097:
1096:
1095:
1092:
1091:
1089:
1085:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1013:
1012:
1009:
1005:
1002:
1000:
997:
996:
994:
990:
987:
986:
984:
980:
977:
976:
974:
970:
967:
965:
962:
961:
959:
955:
952:
950:
947:
946:
944:
940:
937:
936:
934:
930:
927:
925:
922:
920:
917:
916:
914:
910:
907:
905:
902:
901:
899:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
821:
819:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
775:
773:
772:
770:
768:
764:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
729:
727:
725:
721:
718:
716:
712:
709:
707:
702:
698:
695:
691:
687:
683:
676:
671:
669:
664:
662:
657:
656:
653:
642:
638:
634:
630:
626:
622:
619:(1): 87–100.
618:
614:
606:
598:
594:
590:
586:
582:
578:
574:
570:
566:
558:
550:
546:
542:
538:
534:
530:
526:
522:
514:
506:
493:
478:
474:
470:
466:
459:
453:
445:
441:
436:
431:
427:
423:
420:(6): 433–45.
419:
415:
411:
404:
396:
392:
387:
382:
378:
374:
370:
366:
362:
355:
347:
343:
338:
333:
329:
325:
321:
317:
313:
310:(June 2010).
309:
303:
296:
292:
287:
283:
273:
270:
268:
265:
264:
258:
254:
250:
248:
244:
242:
237:
233:
232:
222:
220:
209:
205:
203:
199:
188:
186:
182:
178:
174:
166:
165:
161:
158:
157:
153:
150:
149:
145:
142:
141:
137:
136:
135:
129:
128:
124:
121:
120:
116:
113:
112:
108:
105:
102:
101:
97:
96:
95:
92:
83:
79:
72:
69:
68:
67:
64:
50:
48:
44:
40:
36:
32:
23:
19:
2965:
2740:Dystroglycan
2695:Beta catenin
1927:Microtubules
1795:Beta-keratin
1724:
1673:
1619:
1559:
1481:
1467:
1453:
1390:
1227:
1094:Tropomodulin
1010:
686:cytoskeleton
616:
612:
605:
572:
568:
557:
524:
520:
513:
492:cite journal
480:. Retrieved
452:
417:
413:
403:
368:
364:
354:
322:(6): 507–9.
319:
315:
302:
286:
255:
251:
239:
235:
229:
228:
215:
206:
201:
197:
194:
170:
162:
154:
146:
138:
134:MLC2 genes:
133:
125:
117:
109:
103:
98:
94:MLC1 genes:
93:
89:
80:
76:
65:
61:
49:in England.
37:subunit) of
30:
28:
18:
2886:Plakophilin
2837:Desmoplakin
2597:Tau protein
1371:Cytokeratin
1167:Tropomyosin
715:Myofilament
43:Cao Tianqin
35:polypeptide
2966:See also:
2938:Crescentin
2857:Periplakin
2847:Envoplakin
2735:Dystrophin
2352:axonemal:
1846:Internexin
1825:Peripherin
278:References
219:antiedemic
2555:Centrin 3
2550:Centrin 2
2545:Centrin 1
1883:Syncoilin
1788:Not alpha
1354:filaments
1306:Fibrillin
541:0022-2623
243:(MYL9/12)
2982:Category
2921:Nonhuman
2881:Vinculin
2842:Dystonin
2774:Spectrin
2747:Utrophin
2727:Membrane
2682:Catenins
2614:Stathmin
2602:Dynactin
2482:DYNC2LI1
2477:DYNC1LI2
2472:DYNC1LI1
2137:Kinesins
1941:Tubulins
1830:Vimentin
1362:Type 1/2
1264:Profilin
1259:Gelsolin
1121:Troponin
682:Proteins
633:28658550
597:27796297
589:28783682
549:10072688
482:29 April
477:13591327
444:26385864
395:22955375
346:21246905
261:See also
2908:PLEKHA7
2862:Plectin
2827:Plakins
2752:Ankyrin
2651:Dynamin
2581:Spastin
2576:Katanin
2540:CAMSAP3
2535:CAMSAP2
2530:CAMSAP1
2502:DYNLRB2
2497:DYNLRB1
2467:DYNC1I2
2462:DYNC1I1
2457:DYNC2H1
2452:DYNC1H1
2345:Dyneins
2069:TUBGCP6
2064:TUBGCP5
2059:TUBGCP4
2054:TUBGCP3
2049:TUBGCP2
1878:Synemin
1621:type II
1483:type II
1366:Keratin
1311:Filamin
1252:Destrin
1235:Cofilin
1196:Actinin
767:Myosins
684:of the
641:4327394
435:4764388
386:3602621
337:4875321
308:Zhang Y
236:MYL12a,
221:drugs.
2809:SPTBN5
2804:SPTBN4
2799:SPTBN2
2794:SPTBN1
2784:SPTAN1
2619:Tektin
2512:DYNLT3
2507:DYNLT1
2492:DYNLL2
2487:DYNLL1
2434:DNALI1
2419:DNAH17
2414:DNAH14
2409:DNAH13
2404:DNAH12
2399:DNAH11
2394:DNAH10
2315:KIF26B
2310:KIF26A
2285:KIF21B
2280:KIF21A
2275:KIF20B
2270:KIF20A
2260:KIF18B
2255:KIF18A
2245:KIF16B
2230:KIF13B
2225:KIF13A
2024:TUBB4Q
2009:TUBB2C
2004:TUBB2B
1999:TUBB2A
1979:TUBA4A
1974:TUBA3E
1969:TUBA3D
1964:TUBA3C
1959:TUBA1C
1954:TUBA1B
1949:TUBA1A
1892:Type 5
1851:Nestin
1839:Type 4
1815:Desmin
1808:Type 3
1561:type I
1392:type I
1338:TRIOBP
1004:MYO18B
999:MYO18A
995:XVIII
989:MYO15A
724:Actins
639:
631:
595:
587:
547:
539:
475:
442:
432:
393:
383:
344:
334:
297:(MeSH)
241:MYL12b
183:, and
39:myosin
2869:Talin
2852:MACF1
2820:Other
2779:SPTA1
2644:TEKT5
2639:TEKT4
2634:TEKT3
2629:TEKT2
2624:TEKT1
2607:DCTN1
2590:Other
2444:DNAL4
2439:DNAL1
2429:DNAI2
2424:DNAI1
2389:DNAH9
2384:DNAH8
2379:DNAH7
2374:DNAH6
2369:DNAH5
2364:DNAH3
2359:DNAH2
2354:DNAH1
2335:KIFC3
2330:KIFC2
2325:KIFC1
2320:KIF27
2305:KIF25
2300:KIF24
2295:KIF23
2290:KIF22
2265:KIF19
2250:KIF17
2240:KIF15
2235:KIF14
2220:KIF12
2215:KIF11
2195:KIF5C
2190:KIF5B
2185:KIF5A
2180:KIF4B
2175:KIF4A
2170:KIF3C
2165:KIF3B
2160:KIF2C
2155:KIF2A
2150:KIF1B
2145:KIF1A
2117:MAP1B
2112:MAP1A
2079:TUBE1
2074:TUBD1
2044:TUBG2
2039:TUBG1
2034:TUBB8
2029:TUBB6
2019:TUBB4
2014:TUBB3
1994:TUBB1
1984:TUBA8
1333:Espin
1294:Other
1281:Titin
1087:Other
1076:MYLL1
1071:MYLK2
1061:MYLIP
1046:MYL6B
979:MYO10
969:MYO9B
964:MYO9A
954:MYO7B
949:MYO7A
929:MYO5C
924:MYO5B
919:MYO5A
909:MYO3B
904:MYO3A
894:MYH16
889:MYH15
884:MYH14
879:MYH13
874:MYH11
869:MYH10
854:MYH7B
813:MYO1H
808:MYO1G
803:MYO1F
798:MYO1E
793:MYO1D
788:MYO1C
783:MYO1B
778:MYO1A
693:Human
637:S2CID
593:S2CID
473:S2CID
461:(PDF)
185:MYLK2
177:MYLIP
173:MYL6B
2953:ParM
2948:MreB
2943:FtsZ
2903:ACF7
2896:PKP2
2891:PKP1
2874:TLN1
2789:SPTB
2767:ANK3
2762:ANK2
2757:ANK1
2666:DNM3
2661:DNM2
2656:DNM1
2560:PCM1
2210:KIF9
2205:KIF7
2200:KIF6
2127:MAP4
2122:MAP2
2089:MAPs
1989:TUBB
1932:MAPs
1930:and
1871:NEFH
1866:NEFM
1861:NEFL
1820:GFAP
1468:none
1326:FLNC
1321:FLNB
1316:FLNA
1066:MYLK
1056:MYL9
1051:MYL7
1041:MYL6
1036:MYL5
1031:MYL4
1026:MYL3
1021:MYL2
1016:MYL1
945:VII
939:MYO6
900:III
864:MYH9
859:MYH8
849:MYH7
844:MYH6
839:MYH4
834:MYH3
829:MYH2
824:MYH1
706:ABPs
704:and
629:PMID
585:PMID
545:PMID
537:ISSN
505:help
484:2020
440:PMID
391:PMID
342:PMID
247:CD69
238:and
231:MYL9
202:MYL3
200:and
198:MYL2
181:MYLK
164:MYL9
156:MYL7
148:MYL5
140:MYL2
127:MYL6
119:MYL4
111:MYL3
100:MYL1
2717:GAN
2700:APC
2107:EB3
2102:EB2
2097:EB1
1903:A/C
1586:33B
1581:33A
985:XV
960:IX
935:VI
820:II
621:doi
617:278
577:doi
529:doi
465:doi
430:PMC
422:doi
381:PMC
373:doi
332:PMC
324:doi
175:,
2984::
1913:B2
1908:B1
1901::
1777:80
1772:79
1767:78
1762:77
1757:76
1752:75
1747:74
1742:73
1737:72
1732:71
1716:40
1711:39
1706:28
1701:27
1696:26
1691:25
1686:24
1681:23
1656:86
1651:85
1646:84
1641:83
1636:82
1631:81
1611:38
1606:37
1601:36
1596:35
1591:34
1576:32
1571:31
1528:6C
1523:6B
1518:6A
1498:2A
1473:21
1461:18
1447:20
1442:19
1437:17
1432:16
1427:15
1422:14
1417:13
1412:12
1407:10
1011:LC
975:X
915:V
774:I
757:G2
752:G1
747:C1
737:A2
732:A1
635:.
627:.
615:.
591:.
583:.
571:.
567:.
543:.
535:.
525:42
523:.
496::
494:}}
490:{{
471:.
463:.
438:.
428:.
418:36
416:.
412:.
389:.
379:.
369:70
367:.
363:.
340:.
330:.
318:.
314:.
234:,
187:,
179:,
29:A
1623:/
1563:/
1538:8
1533:7
1513:5
1508:4
1503:3
1493:1
1485:/
1402:9
1394:/
1373:)
1368:,
1364:(
1274:2
1269:1
1245:2
1240:1
1216:4
1211:3
1206:2
1201:1
1187:4
1182:3
1177:2
1172:1
1160:3
1157:2
1154:1
1151:I
1146:2
1143:1
1140:C
1135:3
1132:2
1129:1
1126:T
1114:4
1109:3
1104:2
1099:1
815:)
742:B
674:e
667:t
660:v
643:.
623::
599:.
579::
573:1
551:.
531::
507:)
503:(
486:.
467::
446:.
424::
397:.
375::
348:.
326::
320:1
104:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
