244:
221:
143:
118:
509:
502:
495:
250:
149:
1157:
relative to VLC-1, which may explain the mechanism underlying the differences in cycling kinetics. The importance of this region has however raised skepticism. Further evidence for the contractile-enhancing properties of ALC-1 came from studies employing transgenesis to replace VLC-1 with ALC-1 in
2247:
Ritter O, Luther HP, Haase H, Baltas LG, Baumann G, Schulte HD, Morano I (September 1999). "Expression of atrial myosin light chains but not alpha-myosin heavy chains is correlated in vivo with increased ventricular function in patients with hypertrophic obstructive cardiomyopathy".
2533:
Seidel U, Bober E, Winter B, Lenz S, Lohse P, Goedde HW, Grzeschik KH, Arnold HH (June 1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms".
1996:
Abdelaziz AI, Segaric J, Bartsch H, Petzhold D, Schlegel WP, Kott M, Seefeldt I, Klose J, Bader M, Haase H, Morano I (April 2004). "Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model".
1132:
tissue. Fibers expressing high ALC-1 exhibited a higher maximal velocity and rate of shortening compared to fibers with low amounts of ALC-1, suggesting that ALC-1 increases cycling kinetics of myosin cross-bridges and regulates cardiac
1484:
Zimmermann K, Kautz S, Hajdu G, Winter C, Whalen RG, Starzinski-Powitz A (February 1990). "Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells".
2211:
Morano I, Hädicke K, Haase H, Böhm M, Erdmann E, Schaub MC (April 1997). "Changes in essential myosin light chain isoform expression provide a molecular basis for isometric force regulation in the failing human heart".
257:
156:
2373:
Rayment I, Rypniewski WR, Schmidt-Bäse K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM (July 1993). "Three-dimensional structure of myosin subfragment-1: a molecular motor".
2504:
Seharaseyon J, Bober E, Hsieh CL, Fodor WL, Francke U, Arnold HH, Vanin EF (June 1990). "Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location".
1233:
2598:
Strohman RC, Micou-Eastwood J, Glass CA, Matsuda R (September 1983). "Human fetal muscle and cultured myotubes derived from it contain a fetal-specific myosin light chain".
2836:
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006).
2093:"Hemodynamic performance and myosin light chain-1 expression of the hypertrophied left ventricle in aortic valve disease before and after valve replacement"
1525:
Timson DJ, Trayer HR, Trayer IP (August 1998). "The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function".
1606:"A skeletal muscle-specific enhancer regulated by factors binding to E and CArG boxes is present in the promoter of the mouse myosin light-chain 1A gene"
1871:
Petzhold D, Simsek B, MeiĂźner R, Mahmoodzadeh S, Morano I (July 2014). "Distinct interactions between actin and essential myosin light chain isoforms".
707:
79:
2793:
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, SĂĽltmann H, Poustka A (October 2004).
1065:. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. Relative to ventricular essential light chain
688:
1693:"Myosin transitions in the bovine and human heart. A developmental and anatomical study of heavy and light chain subunits in the atrium and ventricle"
2637:"The rĂ´le of the proline-rich region in A1-type myosin essential light chains: implications for information transmission in the actomyosin complex"
1170:
in whole heart experiments. These studies were supported by further studies in transgenic rats overexpressing ALC-1 which showed enhanced rates of
2901:
1383:
1365:
2565:"A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria"
4710:
928:
921:
4730:
4662:
4647:
4642:
4637:
4632:
4622:
4543:
4252:
4232:
4202:
4197:
4872:
4867:
4862:
4857:
4612:
4602:
4592:
4587:
4558:
4262:
4257:
3304:
3192:
3182:
3157:
3137:
3041:
3021:
1445:
3264:
5216:
2760:"Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1"
2067:
2134:"Myosin isoenzymes in human hypertrophic hearts. Shift in atrial myosin heavy chains and in ventricular myosin light chains"
1656:
Auckland LM, Lambert SJ, Cummins P (November 1986). "Cardiac myosin light and heavy chain isotypes in tetralogy of Fallot".
1348:
3529:
1158:
the mouse ventricle. This study demonstrated an increase in unloaded shortening velocity, both in skinned fibers and in an
2418:"Human essential myosin light chain isoforms revealed distinct myosin binding, sarcomeric sorting, and inotropic activity"
1459:
2894:
1327:
1175:
1167:
1565:"Size and charge requirements for kinetic modulation and actin binding by alkali 1-type myosin essential light chains"
243:
2332:
Yang JH, Zheng DD, Dong NZ, Yang XJ, Song JP, Jiang TB, Cheng XJ, Li HX, Zhou BY, Zhao CM, Jiang WP (November 2006).
1248:
was elevated, and following valve replacement decreased to lower levels; ALC-1 expression also correlated with left
1825:
Morano I, Haase H (May 1997). "Different actin affinities of human cardiac essential myosin light chain isoforms".
220:
4048:
2334:"Mutation of Arg723Gly in beta-myosin heavy chain gene in five Chinese families with hypertrophic cardiomyopathy"
1352:
1331:
4317:
4160:
2887:
752:
1406:"Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones"
5196:
4750:
1229:
142:
117:
2463:"The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions"
2091:
SĂĽtsch G, Brunner UT, von
Schulthess C, Hirzel HO, Hess OM, Turina M, Krayenbuehl HP, Schaub MC (May 1992).
733:
1113:
throughout all of adulthood. Normal atrial function is essential for embryogenesis, as inactivation of the
59:
3457:
1292:
1264:
1022:
1734:"Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis"
4928:
256:
155:
1949:"Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice"
249:
148:
46:
5161:
2172:"Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms"
1225:
1217:
1124:
came from experiments studying fibers from patients expressing a higher level of ALC-1 relative to
1034:
881:
855:
851:
822:
67:
1947:
Fewell JG, Hewett TE, Sanbe A, Klevitsky R, Hayes E, Warshaw D, Maughan D, Robbins J (June 1998).
1776:
Morano M, Zacharzowski U, Maier M, Lange PE, Alexi-Meskishvili V, Haase H, Morano I (July 1996).
1256:
1159:
1030:
885:
847:
826:
1260:
1026:
2051:
2042:
3580:
2934:
131:
1267:, ALC-1 protein expression is shown to be reactivated, and ALC-1 expression correlates with
3849:
2607:
2382:
1241:
2133:
1732:
Huang C, Sheikh F, Hollander M, Cai C, Becker D, Chu PH, Evans S, Chen J (December 2003).
87:
8:
5156:
3789:
2461:
Rotter M, Zimmerman K, Poustka A, Soussi-Yanicostas N, Starzinski-Powitz A (April 1991).
1221:
2678:
Morano I (July 1999). "Tuning the human heart molecular motors by myosin light chains".
2611:
2386:
3609:
3239:
2862:
2837:
2703:
2666:
2581:
2564:
2309:
2293:"A molecular mechanism improving the contractile state in human myocardial hypertrophy"
2292:
2273:
2022:
1850:
1538:
1171:
91:
2819:
2794:
2741:
2716:
2653:
2636:
2487:
2462:
2188:
2171:
1973:
1948:
1908:"Examining the in vivo role of the amino terminus of the essential myosin light chain"
1838:
1802:
1777:
1630:
1605:
1422:
1405:
622:
617:
612:
607:
591:
586:
581:
565:
560:
555:
550:
5007:
3371:
2867:
2824:
2781:
2746:
2695:
2658:
2623:
2586:
2551:
2547:
2521:
2517:
2492:
2439:
2398:
2355:
2350:
2333:
2314:
2265:
2229:
2193:
2152:
2148:
2114:
2073:
2063:
2014:
1978:
1929:
1888:
1842:
1807:
1755:
1714:
1673:
1635:
1586:
1542:
1502:
1498:
1427:
1280:
1276:
1249:
1245:
1206:
1191:
1183:
1179:
1129:
1106:
1046:
1045:
ALC-1 is a 21.6 kDa protein composed of 197 amino acids. ALC-1 is expressed in fetal
1011:
999:
39:
2707:
2670:
2277:
2026:
1854:
4955:
4079:
3434:
3429:
2857:
2849:
2814:
2806:
2771:
2736:
2728:
2687:
2648:
2615:
2576:
2543:
2513:
2482:
2474:
2429:
2390:
2345:
2304:
2257:
2221:
2183:
2144:
2104:
2055:
2050:. Advances in Experimental Medicine and Biology. Vol. 565. Springer. pp.
2006:
1968:
1960:
1919:
1880:
1834:
1797:
1789:
1745:
1704:
1665:
1625:
1617:
1576:
1534:
1494:
1417:
336:
267:
211:
166:
1778:"Regulation of human heart contractility by essential myosin light chain isoforms"
71:
5097:
3711:
3561:
3444:
1237:
1090:
1050:
1003:
311:
95:
1388:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1370:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5060:
4923:
3620:
3451:
2960:
2879:
2040:
Abdelaziz AI, Pagel I, Schlegel WP, Kott M, Monti J, Haase H, Morano I (2005).
1884:
1110:
1094:
1062:
1054:
1018:
1007:
412:
2010:
5210:
5124:
5119:
4084:
3954:
3903:
3853:
3793:
3715:
3683:
3624:
3410:
2929:
2109:
2092:
2059:
1604:
Catala F, Wanner R, Barton P, Cohen A, Wright W, Buckingham M (August 1995).
1581:
1564:
1404:
Kurabayashi M, Komuro I, Tsuchimochi H, Takaku F, Yazaki Y (September 1988).
1194:
developed pressure, maximal velocity of pressure development and relaxation.
1187:
1163:
1134:
537:
508:
501:
494:
2619:
2478:
2394:
1709:
1692:
1669:
472:
350:
4968:
4023:
3778:
3322:
2914:
2871:
2828:
2785:
2750:
2699:
2443:
2359:
2318:
2269:
2225:
2077:
2018:
1933:
1924:
1907:
1892:
1759:
1590:
1073:
region that contains four to eleven residues that are critical for binding
329:
108:
4940:
4918:
2776:
2759:
2691:
2662:
2627:
2590:
2555:
2525:
2496:
2402:
2261:
2233:
2197:
2156:
2118:
1982:
1846:
1811:
1718:
1677:
1639:
1621:
1546:
1506:
1431:
1186:
preparations. Importantly, overexpression of ALC-1 was shown to attenuate
968:
963:
5114:
5065:
4935:
4825:
4155:
3599:
3554:
3473:
3395:
2943:
2853:
2434:
2417:
2416:
Petzhold D, Lossie J, Keller S, Werner S, Haase H, Morano I (June 2011).
1272:
797:
778:
2758:
Arrell DK, Neverova I, Fraser H, Marbán E, Van Eyk JE (September 2001).
5166:
5085:
5075:
4963:
4074:
4053:
3819:
3756:
3751:
3746:
3726:
3701:
3689:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3497:
3379:
3368:
3354:
2970:
2810:
2460:
2043:"Human atrial myosin light chain 1 expression attenuates heart failure"
1209:
1150:
1146:
1070:
1014:
228:
125:
75:
2732:
1793:
1750:
1733:
4995:
4990:
4985:
4945:
4783:
4778:
4773:
4131:
4111:
3766:
3761:
3741:
3736:
3731:
3721:
3630:
3534:
3468:
1121:
1109:
decreases in early postnatal development, but is highly expressed in
652:
295:
282:
194:
181:
83:
1964:
1446:"Entrez Gene: MYL4 myosin, light chain 4, alkali; atrial, embryonic"
1105:
promoter region regulate transcription. ALC-1 expression in cardiac
5109:
5070:
5002:
4975:
4842:
4830:
4705:
4700:
4141:
4136:
4058:
3492:
3487:
3349:
952:
2597:
2372:
1403:
5136:
5090:
4980:
4910:
4879:
4809:
4804:
4768:
4763:
4758:
4725:
4695:
4690:
4685:
4680:
4365:
4297:
4292:
4287:
4282:
4277:
4169:
4106:
3594:
3539:
3480:
3463:
3424:
2910:
2090:
1870:
1268:
1213:
1142:
1138:
1120:
Evidence of ALC-1 isoform expression on contractile mechanics of
988:
764:
719:
637:
633:
2132:
Schaub MC, Tuchschmid CR, Srihari T, Hirzel HO (December 1984).
63:
5055:
5037:
5032:
5027:
5022:
5012:
4847:
4740:
4735:
4720:
4715:
4627:
4573:
4538:
4513:
4508:
4503:
4498:
4488:
4483:
4473:
4458:
4453:
4335:
4330:
4325:
4237:
4227:
4207:
4192:
4187:
4182:
4177:
4043:
3814:
3809:
3566:
3232:
3227:
3217:
2995:
1995:
1137:. Further biochemical studies unveiled a weaker binding of the
936:
674:
517:
2835:
5080:
4852:
4835:
4672:
4667:
4657:
4652:
4617:
4607:
4597:
4582:
4563:
4553:
4548:
4533:
4528:
4523:
4518:
4493:
4478:
4468:
4463:
4448:
4443:
4423:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4383:
4378:
4373:
4345:
4340:
4307:
4302:
4272:
4267:
4247:
4242:
4222:
4212:
4127:
4005:
4000:
3995:
3990:
3985:
3980:
3975:
3970:
3965:
3960:
3944:
3939:
3934:
3929:
3924:
3919:
3914:
3909:
3884:
3879:
3874:
3869:
3864:
3859:
3839:
3834:
3829:
3824:
3804:
3799:
3509:
3439:
3388:
3385:
3382:
3374:
3363:
3360:
3357:
3342:
3337:
3332:
3327:
3299:
3289:
3274:
3207:
3197:
3177:
3152:
3147:
3132:
3122:
3117:
3112:
3107:
3102:
3097:
3082:
3036:
3031:
3026:
3016:
3011:
3006:
2985:
2980:
2975:
2965:
2952:
2792:
2131:
1299:
1154:
1098:
1074:
2291:
Ritter O, Bottez N, Burkard N, Schulte HD, Neyses L (2002).
1775:
5181:
5176:
5171:
5131:
5102:
5017:
4894:
4889:
4884:
4788:
4438:
4433:
4428:
4355:
4350:
4217:
4099:
4094:
4089:
3549:
3544:
3502:
3415:
3405:
3400:
3294:
3284:
3279:
3269:
3254:
3249:
3244:
3167:
3092:
3087:
3077:
3072:
3067:
3062:
3057:
3052:
2170:
Schaub MC, Hefti MA, Zuellig RA, Morano I (February 1998).
1304:
1125:
1078:
1066:
1058:
995:
2757:
2503:
2415:
2290:
2039:
1946:
1483:
2795:"From ORFeome to biology: a functional genomics pipeline"
2717:"DNA cloning using in vitro site-specific recombination"
2169:
1905:
319:
2563:
Arnold HH, Lohse P, Seidel U, Bober E (December 1988).
2246:
1731:
1603:
1563:
Timson DJ, Trayer HR, Smith KJ, Trayer IP (June 1999).
1562:
1464:
Cardiac
Organellar Protein Atlas Knowledgebase (COPaKB)
2562:
2210:
1906:
Sanbe A, Gulick J, Fewell J, Robbins J (August 2001).
1655:
2532:
1460:"Protein sequence of human MYL4 (Uniprot ID: P12829)"
484:
1224:. Altered ALC-1 expression is also altered in other
2714:
1873:
1275:proteins in skinned fiber preparations, as well as
2715:Hartley JL, Temple GF, Brasch MA (November 2000).
2041:
1524:
1399:
1397:
1344:
1342:
1340:
1323:
1321:
1319:
1190:in pressure-overloaded animals, by enhancing left
2331:
1010:tissue. ALC-1 expression is reactivated in human
266:
165:
5208:
2909:
2048:Sliding Filament Mechanism in Muscle Contraction
1866:
1864:
1651:
1649:
50:, ALC1, AMLC, GT1, PRO1957, myosin light chain 4
1394:
1337:
1316:
16:Protein-coding gene in the species Homo sapiens
1771:
1769:
1690:
1558:
1556:
1349:GRCm38: Ensembl release 89: ENSMUSG00000061086
1057:tissue. ALC-1 binds the neck region of muscle
2895:
1861:
1646:
1520:
1518:
1516:
608:positive regulation of ATP-dependent activity
2634:
2214:Journal of Molecular and Cellular Cardiology
618:regulation of the force of heart contraction
1824:
1766:
1553:
1328:GRCh38: Ensembl release 89: ENSG00000198336
2902:
2888:
1513:
1216:up through adulthood in patients with the
1117:gene was embryonic lethal at ED10.5-11.5.
2861:
2818:
2775:
2740:
2652:
2580:
2486:
2433:
2349:
2308:
2187:
2108:
1972:
1923:
1801:
1749:
1708:
1629:
1580:
1421:
1069:, ALC-1 has an additional ~40 amino-acid
1197:
5209:
2677:
2883:
1953:The Journal of Clinical Investigation
1782:The Journal of Clinical Investigation
1438:
365:cardiac muscle tissue of right atrium
271:
232:
227:
170:
129:
124:
2297:Experimental and Clinical Cardiology
1912:The Journal of Biological Chemistry
1691:Cummins P, Lambert SJ (June 1986).
1569:The Journal of Biological Chemistry
1410:The Journal of Biological Chemistry
1212:has shown to abnormally persist in
13:
2582:10.1111/j.1432-1033.1988.tb14428.x
2453:
1539:10.1046/j.1432-1327.1998.2550654.x
14:
5228:
2635:Timson DJ, Trayer IP (Jan 1997).
1089:ALC-1 is expressed very early in
991:that in humans is encoded by the
3530:Wiskott–Aldrich syndrome protein
2569:European Journal of Biochemistry
2351:10.1097/00029330-200611010-00004
1527:European Journal of Biochemistry
507:
500:
493:
255:
248:
242:
219:
154:
147:
141:
116:
4751:Microtubule organising proteins
2409:
2366:
2325:
2284:
2240:
2204:
2163:
2125:
2084:
2033:
1989:
1940:
1899:
1818:
1725:
1684:
1597:
1286:
1255:Additionally, in patients with
1234:infundibular pulmonary stenosis
2149:10.1093/eurheartj/5.suppl_f.85
1610:Molecular and Cellular Biology
1477:
1452:
1376:
1358:
1236:. Moreover, in patients with
998:. ALC-1 is expressed in fetal
518:More reference expression data
473:More reference expression data
1:
4798:Microtubule severing proteins
2838:"The LIFEdb database in 2006"
2680:Journal of Molecular Medicine
2654:10.1016/S0014-5793(96)01314-2
2250:Journal of Molecular Medicine
2189:10.1016/s0008-6363(97)00258-7
2052:283–92, discussion 92, 405–15
1999:Journal of Molecular Medicine
1839:10.1016/s0014-5793(97)00390-6
1423:10.1016/S0021-9258(18)68333-4
1310:
1230:Double outlet right ventricle
1053:, as well as fetal and adult
1006:, as well as fetal and adult
985:Essential Light Chain, Atrial
566:myosin II heavy chain binding
240:
139:
5217:Genes on human chromosome 17
3458:actin depolymerizing factors
2548:10.1016/0378-1119(88)90231-4
2518:10.1016/0888-7543(90)90554-8
1499:10.1016/0022-2836(90)90261-J
1487:Journal of Molecular Biology
1040:
981:Atrial Light Chain-1 (ALC-1)
7:
4936:Plakoglobin (gamma catenin)
1265:hypertrophic cardiomyopathy
1244:, ALC-1 expression in left
1084:
1023:hypertrophic cardiomyopathy
10:
5233:
2848:(Database issue): D415–8.
1885:10.1016/j.bbrc.2014.05.040
613:cardiac muscle contraction
5192:
5149:
5048:
4954:
4909:
4818:
4797:
4749:
4572:
4364:
4316:
4168:
4154:
4120:
4067:
4036:
4016:
3895:
3777:
3608:
3590:
3579:
3522:
3315:
2994:
2951:
2942:
2928:
2921:
2011:10.1007/s00109-004-0525-4
1384:"Mouse PubMed Reference:"
1366:"Human PubMed Reference:"
1226:congenital heart diseases
1035:congenital heart diseases
967:
962:
958:
951:
935:
929:Chr 11: 104.55 – 104.6 Mb
916:
903:
899:
878:
874:
867:
844:
840:
819:
815:
808:
795:
791:
776:
772:
763:
750:
746:
731:
727:
718:
705:
701:
686:
682:
673:
658:
651:
647:
631:
536:
532:
515:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
5162:Prokaryotic cytoskeleton
2110:10.1161/01.res.70.5.1035
2060:10.1007/0-387-24990-7_21
1582:10.1074/jbc.274.26.18271
1218:congenital heart disease
2620:10.1126/science.6879193
2422:Cardiovascular Research
2395:10.1126/science.8316857
2338:Chinese Medical Journal
2176:Cardiovascular Research
1710:10.1161/01.res.58.6.846
1658:Cardiovascular Research
1257:ischemic cardiomyopathy
1160:in vitro motility assay
1031:ischemic cardiomyopathy
922:Chr 17: 47.2 – 47.22 Mb
623:muscle filament sliding
447:interventricular septum
439:internal carotid artery
2842:Nucleic Acids Research
2467:Nucleic Acids Research
2226:10.1006/jmcc.1996.0353
2141:European Heart Journal
1925:10.1074/jbc.M009975200
1261:dilated cardiomyopathy
1182:developed pressure in
1162:, as well as enhanced
1027:dilated cardiomyopathy
556:actin filament binding
431:atrioventricular valve
273:11 E1|11 67.79 cM
3782:(hard alpha-keratins)
3613:(soft alpha-keratins)
2777:10.1161/hh1801.097240
2692:10.1007/s001099900031
2479:10.1093/nar/19.7.1497
2262:10.1007/s001099900030
1670:10.1093/cvr/20.11.828
1622:10.1128/mcb.15.8.4585
1198:Clinical significance
561:actin monomer binding
234:Chromosome 11 (mouse)
132:Chromosome 17 (human)
5197:cytoskeletal defects
5157:Major sperm proteins
2764:Circulation Research
2143:. 5 Suppl F: 85–93.
2097:Circulation Research
1697:Circulation Research
1242:aortic insufficiency
1101:and CArG box in the
1021:diseases, including
3610:Epithelial keratins
2612:1983Sci...221..955S
2387:1993Sci...261...50R
1252:systolic pressure.
1222:tetralogy of Fallot
1047:cardiac ventricular
1000:cardiac ventricular
551:calcium ion binding
427:endocardial cushion
2854:10.1093/nar/gkj139
2811:10.1101/gr.2576704
2435:10.1093/cvr/cvr026
1178:, as well as left
753:ENSMUSG00000061086
601:Biological process
575:Cellular component
544:Molecular function
5204:
5203:
5145:
5144:
4905:
4904:
4150:
4149:
4032:
4031:
3575:
3574:
3518:
3517:
2733:10.1101/gr.143000
2069:978-0-387-24989-6
1794:10.1172/JCI118813
1751:10.1242/dev.00831
1281:ejection fraction
1184:Langendorff heart
1097:development; two
978:
977:
974:
973:
947:
946:
912:
911:
893:
892:
863:
862:
834:
833:
804:
803:
785:
784:
759:
758:
740:
739:
714:
713:
695:
694:
643:
642:
528:
527:
524:
523:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
5224:
4166:
4165:
3606:
3605:
3588:
3587:
2949:
2948:
2940:
2939:
2926:
2925:
2904:
2897:
2890:
2881:
2880:
2875:
2865:
2832:
2822:
2805:(10B): 2136–44.
2789:
2779:
2754:
2744:
2711:
2674:
2656:
2631:
2594:
2584:
2559:
2529:
2500:
2490:
2448:
2447:
2437:
2413:
2407:
2406:
2370:
2364:
2363:
2353:
2329:
2323:
2322:
2312:
2288:
2282:
2281:
2244:
2238:
2237:
2208:
2202:
2201:
2191:
2167:
2161:
2160:
2138:
2129:
2123:
2122:
2112:
2088:
2082:
2081:
2045:
2037:
2031:
2030:
1993:
1987:
1986:
1976:
1944:
1938:
1937:
1927:
1903:
1897:
1896:
1868:
1859:
1858:
1822:
1816:
1815:
1805:
1773:
1764:
1763:
1753:
1729:
1723:
1722:
1712:
1688:
1682:
1681:
1653:
1644:
1643:
1633:
1601:
1595:
1594:
1584:
1560:
1551:
1550:
1522:
1511:
1510:
1481:
1475:
1474:
1472:
1470:
1456:
1450:
1449:
1442:
1436:
1435:
1425:
1401:
1392:
1391:
1380:
1374:
1373:
1362:
1356:
1346:
1335:
1325:
1149:of ALC-1 to the
1128:in cardiac left
983:, also known as
960:
959:
931:
924:
907:
897:
896:
888:
872:
871:
868:RefSeq (protein)
858:
838:
837:
829:
813:
812:
789:
788:
770:
769:
744:
743:
725:
724:
699:
698:
680:
679:
649:
648:
534:
533:
520:
511:
504:
497:
490:
489:
475:
415:
413:Top expressed in
408:
407:
353:
351:Top expressed in
346:
345:
325:
324:
308:
307:
298:
285:
274:
259:
252:
246:
235:
223:
207:
206:
197:
184:
173:
158:
151:
145:
134:
120:
104:
103:
98:
96:MYL4 - orthologs
49:
42:
21:
20:
5232:
5231:
5227:
5226:
5225:
5223:
5222:
5221:
5207:
5206:
5205:
5200:
5188:
5141:
5044:
4950:
4901:
4814:
4793:
4745:
4568:
4360:
4312:
4158:
4146:
4116:
4063:
4028:
4012:
3896:Ungrouped alpha
3891:
3781:
3773:
3612:
3598:
3592:
3582:
3571:
3514:
3311:
2990:
2932:
2917:
2908:
2878:
2799:Genome Research
2727:(11): 1788–95.
2721:Genome Research
2606:(4614): 955–7.
2473:(7): 1497–504.
2456:
2454:Further reading
2451:
2414:
2410:
2371:
2367:
2330:
2326:
2289:
2285:
2245:
2241:
2209:
2205:
2168:
2164:
2136:
2130:
2126:
2089:
2085:
2070:
2038:
2034:
1994:
1990:
1965:10.1172/JCI2825
1945:
1941:
1918:(35): 32682–6.
1904:
1900:
1869:
1862:
1823:
1819:
1774:
1767:
1730:
1726:
1689:
1685:
1654:
1647:
1602:
1598:
1575:(26): 18271–7.
1561:
1554:
1523:
1514:
1482:
1478:
1468:
1466:
1458:
1457:
1453:
1444:
1443:
1439:
1416:(27): 13930–6.
1402:
1395:
1382:
1381:
1377:
1364:
1363:
1359:
1347:
1338:
1326:
1317:
1313:
1289:
1271:sensitivity of
1238:aortic stenosis
1200:
1091:skeletal muscle
1087:
1077:and modulating
1051:skeletal muscle
1043:
1004:skeletal muscle
969:View/Edit Mouse
964:View/Edit Human
927:
920:
917:Location (UCSC)
905:
884:
880:
854:
850:
846:
825:
821:
734:ENSG00000198336
627:
596:
570:
516:
506:
505:
499:
498:
471:
462:
457:
455:right lung lobe
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
391:
387:
385:trabecular bone
383:
379:
377:right ventricle
375:
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
5230:
5220:
5219:
5202:
5201:
5193:
5190:
5189:
5187:
5186:
5185:
5184:
5179:
5174:
5169:
5159:
5153:
5151:
5147:
5146:
5143:
5142:
5140:
5139:
5134:
5129:
5128:
5127:
5122:
5112:
5107:
5106:
5105:
5095:
5094:
5093:
5088:
5083:
5078:
5073:
5068:
5063:
5061:Corneodesmosin
5052:
5050:
5046:
5045:
5043:
5042:
5041:
5040:
5035:
5030:
5025:
5020:
5015:
5010:
5000:
4999:
4998:
4993:
4988:
4978:
4973:
4972:
4971:
4960:
4958:
4952:
4951:
4949:
4948:
4943:
4938:
4933:
4932:
4931:
4921:
4915:
4913:
4907:
4906:
4903:
4902:
4900:
4899:
4898:
4897:
4892:
4887:
4877:
4876:
4875:
4870:
4865:
4860:
4855:
4845:
4840:
4839:
4838:
4828:
4822:
4820:
4816:
4815:
4813:
4812:
4807:
4801:
4799:
4795:
4794:
4792:
4791:
4786:
4781:
4776:
4771:
4766:
4761:
4755:
4753:
4747:
4746:
4744:
4743:
4738:
4733:
4728:
4723:
4718:
4713:
4708:
4703:
4698:
4693:
4688:
4683:
4676:
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4635:
4630:
4625:
4620:
4615:
4610:
4605:
4600:
4595:
4590:
4585:
4578:
4576:
4570:
4569:
4567:
4566:
4561:
4556:
4551:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4511:
4506:
4501:
4496:
4491:
4486:
4481:
4476:
4471:
4466:
4461:
4456:
4451:
4446:
4441:
4436:
4431:
4426:
4421:
4416:
4411:
4406:
4401:
4396:
4391:
4386:
4381:
4376:
4370:
4368:
4362:
4361:
4359:
4358:
4353:
4348:
4343:
4338:
4333:
4328:
4322:
4320:
4314:
4313:
4311:
4310:
4305:
4300:
4295:
4290:
4285:
4280:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4174:
4172:
4163:
4152:
4151:
4148:
4147:
4145:
4144:
4139:
4134:
4128:Nuclear lamins
4124:
4122:
4118:
4117:
4115:
4114:
4109:
4104:
4103:
4102:
4097:
4092:
4082:
4077:
4071:
4069:
4065:
4064:
4062:
4061:
4056:
4051:
4046:
4040:
4038:
4034:
4033:
4030:
4029:
4027:
4026:
4020:
4018:
4014:
4013:
4011:
4010:
4009:
4008:
4003:
3998:
3993:
3988:
3983:
3978:
3973:
3968:
3963:
3950:
3949:
3948:
3947:
3942:
3937:
3932:
3927:
3922:
3917:
3912:
3899:
3897:
3893:
3892:
3890:
3889:
3888:
3887:
3882:
3877:
3872:
3867:
3862:
3845:
3844:
3843:
3842:
3837:
3832:
3827:
3822:
3817:
3812:
3807:
3802:
3785:
3783:
3775:
3774:
3772:
3771:
3770:
3769:
3764:
3759:
3754:
3749:
3744:
3739:
3734:
3729:
3724:
3707:
3706:
3705:
3704:
3694:
3693:
3692:
3680:
3679:
3678:
3673:
3668:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3616:
3614:
3603:
3585:
3577:
3576:
3573:
3572:
3570:
3569:
3564:
3559:
3558:
3557:
3552:
3547:
3537:
3532:
3526:
3524:
3520:
3519:
3516:
3515:
3513:
3512:
3507:
3506:
3505:
3500:
3490:
3485:
3484:
3483:
3478:
3477:
3476:
3471:
3454:
3452:Arp2/3 complex
3449:
3448:
3447:
3442:
3437:
3432:
3421:
3420:
3419:
3418:
3413:
3408:
3403:
3393:
3392:
3391:
3377:
3366:
3347:
3346:
3345:
3340:
3335:
3330:
3319:
3317:
3313:
3312:
3310:
3309:
3308:
3307:
3302:
3297:
3292:
3287:
3282:
3277:
3272:
3267:
3262:
3257:
3252:
3247:
3237:
3236:
3235:
3230:
3222:
3221:
3220:
3212:
3211:
3210:
3202:
3201:
3200:
3195:
3187:
3186:
3185:
3180:
3172:
3171:
3170:
3162:
3161:
3160:
3155:
3150:
3142:
3141:
3140:
3135:
3127:
3126:
3125:
3120:
3115:
3110:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3047:
3046:
3045:
3039:
3034:
3029:
3024:
3019:
3014:
3009:
3000:
2998:
2992:
2991:
2989:
2988:
2983:
2978:
2973:
2968:
2963:
2957:
2955:
2946:
2937:
2930:Microfilaments
2923:
2919:
2918:
2907:
2906:
2899:
2892:
2884:
2877:
2876:
2833:
2790:
2755:
2712:
2675:
2632:
2595:
2560:
2530:
2501:
2457:
2455:
2452:
2450:
2449:
2408:
2381:(5117): 50–8.
2365:
2344:(21): 1785–9.
2324:
2303:(2–3): 151–7.
2283:
2239:
2220:(4): 1177–87.
2203:
2182:(2): 381–404.
2162:
2124:
2103:(5): 1035–43.
2083:
2068:
2032:
1988:
1959:(12): 2630–9.
1939:
1898:
1860:
1817:
1765:
1744:(24): 6111–9.
1724:
1683:
1664:(11): 828–36.
1645:
1616:(8): 4585–96.
1596:
1552:
1512:
1476:
1451:
1437:
1393:
1375:
1357:
1336:
1314:
1312:
1309:
1308:
1307:
1302:
1288:
1285:
1205:expression in
1199:
1196:
1095:cardiac muscle
1086:
1083:
1055:cardiac atrial
1042:
1039:
1019:cardiac muscle
1008:cardiac atrial
976:
975:
972:
971:
966:
956:
955:
949:
948:
945:
944:
942:
940:
933:
932:
925:
918:
914:
913:
910:
909:
901:
900:
894:
891:
890:
876:
875:
869:
865:
864:
861:
860:
842:
841:
835:
832:
831:
817:
816:
810:
806:
805:
802:
801:
793:
792:
786:
783:
782:
774:
773:
767:
761:
760:
757:
756:
748:
747:
741:
738:
737:
729:
728:
722:
716:
715:
712:
711:
703:
702:
696:
693:
692:
684:
683:
677:
671:
670:
665:
660:
656:
655:
645:
644:
641:
640:
629:
628:
626:
625:
620:
615:
610:
604:
602:
598:
597:
595:
594:
592:myosin complex
589:
584:
578:
576:
572:
571:
569:
568:
563:
558:
553:
547:
545:
541:
540:
530:
529:
526:
525:
522:
521:
513:
512:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
389:left ventricle
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
9:
6:
4:
3:
2:
5229:
5218:
5215:
5214:
5212:
5199:
5198:
5191:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5164:
5163:
5160:
5158:
5155:
5154:
5152:
5148:
5138:
5135:
5133:
5130:
5126:
5123:
5121:
5118:
5117:
5116:
5113:
5111:
5108:
5104:
5101:
5100:
5099:
5096:
5092:
5089:
5087:
5084:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5062:
5059:
5058:
5057:
5054:
5053:
5051:
5047:
5039:
5036:
5034:
5031:
5029:
5026:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5005:
5004:
5001:
4997:
4994:
4992:
4989:
4987:
4984:
4983:
4982:
4979:
4977:
4974:
4970:
4967:
4966:
4965:
4962:
4961:
4959:
4957:
4953:
4947:
4944:
4942:
4941:Delta catenin
4939:
4937:
4934:
4930:
4927:
4926:
4925:
4922:
4920:
4919:Alpha catenin
4917:
4916:
4914:
4912:
4908:
4896:
4893:
4891:
4888:
4886:
4883:
4882:
4881:
4878:
4874:
4871:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4850:
4849:
4846:
4844:
4841:
4837:
4834:
4833:
4832:
4829:
4827:
4824:
4823:
4821:
4817:
4811:
4808:
4806:
4803:
4802:
4800:
4796:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4772:
4770:
4767:
4765:
4762:
4760:
4757:
4756:
4754:
4752:
4748:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:cytoplasmic:
4678:
4677:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4619:
4616:
4614:
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4594:
4591:
4589:
4586:
4584:
4580:
4579:
4577:
4575:
4571:
4565:
4562:
4560:
4557:
4555:
4552:
4550:
4547:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4505:
4502:
4500:
4497:
4495:
4492:
4490:
4487:
4485:
4482:
4480:
4477:
4475:
4472:
4470:
4467:
4465:
4462:
4460:
4457:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4410:
4407:
4405:
4402:
4400:
4397:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4371:
4369:
4367:
4363:
4357:
4354:
4352:
4349:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4327:
4324:
4323:
4321:
4319:
4315:
4309:
4306:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4284:
4281:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4175:
4173:
4171:
4167:
4164:
4162:
4157:
4153:
4143:
4140:
4138:
4135:
4133:
4129:
4126:
4125:
4123:
4119:
4113:
4110:
4108:
4105:
4101:
4098:
4096:
4093:
4091:
4088:
4087:
4086:
4085:Neurofilament
4083:
4081:
4078:
4076:
4073:
4072:
4070:
4066:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4041:
4039:
4035:
4025:
4022:
4021:
4019:
4015:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3958:
3957:
3956:
3955:chromosome 12
3952:
3951:
3946:
3943:
3941:
3938:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3907:
3906:
3905:
3904:chromosome 17
3901:
3900:
3898:
3894:
3886:
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3858:
3857:
3856:
3855:
3854:chromosome 12
3851:
3847:
3846:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3797:
3796:
3795:
3794:chromosome 17
3791:
3787:
3786:
3784:
3780:
3779:Hair keratins
3776:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3719:
3718:
3717:
3716:chromosome 12
3713:
3709:
3708:
3703:
3700:
3699:
3698:
3695:
3691:
3688:
3687:
3686:
3685:
3684:chromosome 12
3681:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3628:
3627:
3626:
3625:chromosome 17
3622:
3618:
3617:
3615:
3611:
3607:
3604:
3601:
3596:
3589:
3586:
3584:
3581:Intermediate
3578:
3568:
3565:
3563:
3560:
3556:
3553:
3551:
3548:
3546:
3543:
3542:
3541:
3538:
3536:
3533:
3531:
3528:
3527:
3525:
3521:
3511:
3508:
3504:
3501:
3499:
3496:
3495:
3494:
3491:
3489:
3486:
3482:
3479:
3475:
3472:
3470:
3467:
3466:
3465:
3462:
3461:
3460:
3459:
3455:
3453:
3450:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3427:
3426:
3423:
3422:
3417:
3414:
3412:
3409:
3407:
3404:
3402:
3399:
3398:
3397:
3394:
3390:
3387:
3384:
3381:
3378:
3376:
3373:
3370:
3367:
3365:
3362:
3359:
3356:
3353:
3352:
3351:
3348:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3325:
3324:
3321:
3320:
3318:
3314:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3263:
3261:
3258:
3256:
3253:
3251:
3248:
3246:
3243:
3242:
3241:
3238:
3234:
3231:
3229:
3226:
3225:
3223:
3219:
3216:
3215:
3213:
3209:
3206:
3205:
3203:
3199:
3196:
3194:
3191:
3190:
3188:
3184:
3181:
3179:
3176:
3175:
3173:
3169:
3166:
3165:
3163:
3159:
3156:
3154:
3151:
3149:
3146:
3145:
3143:
3139:
3136:
3134:
3131:
3130:
3128:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3050:
3048:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3004:
3002:
3001:
2999:
2997:
2993:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2959:
2958:
2956:
2954:
2950:
2947:
2945:
2941:
2938:
2936:
2931:
2927:
2924:
2920:
2916:
2912:
2905:
2900:
2898:
2893:
2891:
2886:
2885:
2882:
2873:
2869:
2864:
2859:
2855:
2851:
2847:
2843:
2839:
2834:
2830:
2826:
2821:
2816:
2812:
2808:
2804:
2800:
2796:
2791:
2787:
2783:
2778:
2773:
2769:
2765:
2761:
2756:
2752:
2748:
2743:
2738:
2734:
2730:
2726:
2722:
2718:
2713:
2709:
2705:
2701:
2697:
2693:
2689:
2686:(7): 544–55.
2685:
2681:
2676:
2672:
2668:
2664:
2660:
2655:
2650:
2646:
2642:
2638:
2633:
2629:
2625:
2621:
2617:
2613:
2609:
2605:
2601:
2596:
2592:
2588:
2583:
2578:
2574:
2570:
2566:
2561:
2557:
2553:
2549:
2545:
2542:(1): 135–46.
2541:
2537:
2531:
2527:
2523:
2519:
2515:
2512:(2): 289–93.
2511:
2507:
2502:
2498:
2494:
2489:
2484:
2480:
2476:
2472:
2468:
2464:
2459:
2458:
2445:
2441:
2436:
2431:
2428:(3): 513–20.
2427:
2423:
2419:
2412:
2404:
2400:
2396:
2392:
2388:
2384:
2380:
2376:
2369:
2361:
2357:
2352:
2347:
2343:
2339:
2335:
2328:
2320:
2316:
2311:
2306:
2302:
2298:
2294:
2287:
2279:
2275:
2271:
2267:
2263:
2259:
2256:(9): 677–85.
2255:
2251:
2243:
2235:
2231:
2227:
2223:
2219:
2215:
2207:
2199:
2195:
2190:
2185:
2181:
2177:
2173:
2166:
2158:
2154:
2150:
2146:
2142:
2135:
2128:
2120:
2116:
2111:
2106:
2102:
2098:
2094:
2087:
2079:
2075:
2071:
2065:
2061:
2057:
2053:
2049:
2044:
2036:
2028:
2024:
2020:
2016:
2012:
2008:
2005:(4): 265–74.
2004:
2000:
1992:
1984:
1980:
1975:
1970:
1966:
1962:
1958:
1954:
1950:
1943:
1935:
1931:
1926:
1921:
1917:
1913:
1909:
1902:
1894:
1890:
1886:
1882:
1878:
1874:
1867:
1865:
1856:
1852:
1848:
1844:
1840:
1836:
1832:
1828:
1821:
1813:
1809:
1804:
1799:
1795:
1791:
1788:(2): 467–73.
1787:
1783:
1779:
1772:
1770:
1761:
1757:
1752:
1747:
1743:
1739:
1735:
1728:
1720:
1716:
1711:
1706:
1703:(6): 846–58.
1702:
1698:
1694:
1687:
1679:
1675:
1671:
1667:
1663:
1659:
1652:
1650:
1641:
1637:
1632:
1627:
1623:
1619:
1615:
1611:
1607:
1600:
1592:
1588:
1583:
1578:
1574:
1570:
1566:
1559:
1557:
1548:
1544:
1540:
1536:
1533:(3): 654–62.
1532:
1528:
1521:
1519:
1517:
1508:
1504:
1500:
1496:
1493:(3): 505–13.
1492:
1488:
1480:
1465:
1461:
1455:
1447:
1441:
1433:
1429:
1424:
1419:
1415:
1411:
1407:
1400:
1398:
1389:
1385:
1379:
1371:
1367:
1361:
1354:
1350:
1345:
1343:
1341:
1333:
1329:
1324:
1322:
1320:
1315:
1306:
1303:
1301:
1298:
1297:
1296:
1294:
1284:
1282:
1279:dP/dtmax and
1278:
1274:
1270:
1266:
1262:
1258:
1253:
1251:
1247:
1243:
1239:
1235:
1231:
1227:
1223:
1219:
1215:
1211:
1208:
1204:
1195:
1193:
1189:
1188:heart failure
1185:
1181:
1177:
1173:
1169:
1165:
1164:contractility
1161:
1156:
1152:
1148:
1144:
1140:
1136:
1135:contractility
1131:
1127:
1123:
1118:
1116:
1112:
1108:
1104:
1100:
1096:
1092:
1082:
1080:
1076:
1072:
1068:
1064:
1060:
1056:
1052:
1048:
1038:
1036:
1032:
1028:
1024:
1020:
1016:
1013:
1009:
1005:
1001:
997:
994:
990:
986:
982:
970:
965:
961:
957:
954:
950:
943:
941:
938:
934:
930:
926:
923:
919:
915:
908:
902:
898:
895:
889:
887:
883:
877:
873:
870:
866:
859:
857:
853:
849:
843:
839:
836:
830:
828:
824:
818:
814:
811:
809:RefSeq (mRNA)
807:
800:
799:
794:
790:
787:
781:
780:
775:
771:
768:
766:
762:
755:
754:
749:
745:
742:
736:
735:
730:
726:
723:
721:
717:
710:
709:
704:
700:
697:
691:
690:
685:
681:
678:
676:
672:
669:
666:
664:
661:
657:
654:
650:
646:
639:
635:
630:
624:
621:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
593:
590:
588:
585:
583:
580:
579:
577:
574:
573:
567:
564:
562:
559:
557:
554:
552:
549:
548:
546:
543:
542:
539:
538:Gene ontology
535:
531:
519:
514:
510:
503:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
369:apex of heart
368:
364:
361:right auricle
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
5194:
4969:Dystroglycan
4924:Beta catenin
4156:Microtubules
4024:Beta-keratin
3953:
3902:
3848:
3788:
3710:
3696:
3682:
3619:
3456:
3323:Tropomodulin
3259:
2915:cytoskeleton
2845:
2841:
2802:
2798:
2770:(6): 480–7.
2767:
2763:
2724:
2720:
2683:
2679:
2644:
2641:FEBS Letters
2640:
2603:
2599:
2575:(1): 53–60.
2572:
2568:
2539:
2535:
2509:
2505:
2470:
2466:
2425:
2421:
2411:
2378:
2374:
2368:
2341:
2337:
2327:
2300:
2296:
2286:
2253:
2249:
2242:
2217:
2213:
2206:
2179:
2175:
2165:
2140:
2127:
2100:
2096:
2086:
2047:
2035:
2002:
1998:
1991:
1956:
1952:
1942:
1915:
1911:
1901:
1879:(3): 284–8.
1876:
1872:
1830:
1827:FEBS Letters
1826:
1820:
1785:
1781:
1741:
1737:
1727:
1700:
1696:
1686:
1661:
1657:
1613:
1609:
1599:
1572:
1568:
1530:
1526:
1490:
1486:
1479:
1467:. Retrieved
1463:
1454:
1440:
1413:
1409:
1387:
1378:
1369:
1360:
1290:
1287:Interactions
1254:
1202:
1201:
1119:
1114:
1102:
1088:
1044:
992:
984:
980:
979:
904:
882:NP_001002841
879:
856:NM_001355755
852:NM_001355754
845:
823:NM_001002841
820:
796:
777:
751:
732:
706:
687:
667:
662:
435:aortic valve
335:
328:
294:104,595,753
281:104,550,663
55:External IDs
18:
5115:Plakophilin
5066:Desmoplakin
4826:Tau protein
3600:Cytokeratin
3396:Tropomyosin
2944:Myofilament
2647:(1): 31–6.
1833:(1): 71–4.
1738:Development
1277:ventricular
1273:myofilament
1250:ventricular
1207:ventricular
1192:ventricular
1180:ventricular
1172:contraction
1130:ventricular
1017:in various
1012:ventricular
443:human fetus
397:bone marrow
193:47,223,679
180:47,200,446
33:Identifiers
5195:See also:
5167:Crescentin
5086:Periplakin
5076:Envoplakin
4964:Dystrophin
4581:axonemal:
4075:Internexin
4054:Peripherin
1355:, May 2017
1334:, May 2017
1311:References
1246:ventricles
1210:myocardium
1176:relaxation
1168:relaxation
1151:C-terminus
1147:N-terminus
1122:sarcomeres
1107:ventricles
1081:kinetics.
1071:N-terminal
1049:and fetal
1015:myocardium
1002:and fetal
451:right lung
339:(ortholog)
76:HomoloGene
4784:Centrin 3
4779:Centrin 2
4774:Centrin 1
4112:Syncoilin
4017:Not alpha
3583:filaments
3535:Fibrillin
1293:interacts
1061:in adult
1041:Structure
886:NP_002467
848:NM_010858
827:NM_002476
653:Orthologs
373:vena cava
84:GeneCards
5211:Category
5150:Nonhuman
5110:Vinculin
5071:Dystonin
5003:Spectrin
4976:Utrophin
4956:Membrane
4911:Catenins
4843:Stathmin
4831:Dynactin
4711:DYNC2LI1
4706:DYNC1LI2
4701:DYNC1LI1
4366:Kinesins
4170:Tubulins
4059:Vimentin
3591:Type 1/2
3493:Profilin
3488:Gelsolin
3350:Troponin
2911:Proteins
2872:16381901
2829:15489336
2786:11557734
2751:11076863
2708:23819033
2700:10494800
2671:28266152
2506:Genomics
2444:21262909
2360:17097032
2319:19649240
2278:19888645
2270:10569205
2078:16106982
2027:19506306
2019:14985854
1934:11432848
1893:24857983
1855:22222814
1760:14573518
1591:10373429
1351:–
1330:–
1214:neonates
1085:Function
953:Wikidata
632:Sources:
381:testicle
172:17q21.32
5137:PLEKHA7
5091:Plectin
5056:Plakins
4981:Ankyrin
4880:Dynamin
4810:Spastin
4805:Katanin
4769:CAMSAP3
4764:CAMSAP2
4759:CAMSAP1
4731:DYNLRB2
4726:DYNLRB1
4696:DYNC1I2
4691:DYNC1I1
4686:DYNC2H1
4681:DYNC1H1
4574:Dyneins
4298:TUBGCP6
4293:TUBGCP5
4288:TUBGCP4
4283:TUBGCP3
4278:TUBGCP2
4107:Synemin
3850:type II
3712:type II
3595:Keratin
3540:Filamin
3481:Destrin
3464:Cofilin
3425:Actinin
2996:Myosins
2913:of the
2863:1347501
2663:9000508
2628:6879193
2608:Bibcode
2600:Science
2591:2849544
2556:2458299
2526:2129532
2497:2027757
2403:8316857
2383:Bibcode
2375:Science
2310:2719172
2234:9160869
2198:9614495
2157:6241906
2119:1533180
1983:9637696
1847:9180271
1812:8755658
1719:3719931
1678:3621284
1640:7623850
1547:9738905
1507:2308163
1469:30 June
1432:3417683
1353:Ensembl
1332:Ensembl
1269:calcium
1143:Proline
1139:Alanine
1099:E-boxes
989:protein
765:UniProt
720:Ensembl
659:Species
638:QuickGO
582:cytosol
314:pattern
40:Aliases
5038:SPTBN5
5033:SPTBN4
5028:SPTBN2
5023:SPTBN1
5013:SPTAN1
4848:Tektin
4741:DYNLT3
4736:DYNLT1
4721:DYNLL2
4716:DYNLL1
4663:DNALI1
4648:DNAH17
4643:DNAH14
4638:DNAH13
4633:DNAH12
4628:DNAH11
4623:DNAH10
4544:KIF26B
4539:KIF26A
4514:KIF21B
4509:KIF21A
4504:KIF20B
4499:KIF20A
4489:KIF18B
4484:KIF18A
4474:KIF16B
4459:KIF13B
4454:KIF13A
4253:TUBB4Q
4238:TUBB2C
4233:TUBB2B
4228:TUBB2A
4208:TUBA4A
4203:TUBA3E
4198:TUBA3D
4193:TUBA3C
4188:TUBA1C
4183:TUBA1B
4178:TUBA1A
4121:Type 5
4080:Nestin
4068:Type 4
4044:Desmin
4037:Type 3
3790:type I
3621:type I
3567:TRIOBP
3233:MYO18B
3228:MYO18A
3224:XVIII
3218:MYO15A
2953:Actins
2870:
2860:
2827:
2820:528930
2817:
2784:
2749:
2742:310948
2739:
2706:
2698:
2669:
2661:
2626:
2589:
2554:
2524:
2495:
2488:333907
2485:
2442:
2401:
2358:
2317:
2307:
2276:
2268:
2232:
2196:
2155:
2117:
2076:
2066:
2025:
2017:
1981:
1974:508853
1971:
1932:
1891:
1853:
1845:
1810:
1803:507451
1800:
1758:
1717:
1676:
1638:
1631:230699
1628:
1589:
1545:
1505:
1430:
1295:with:
1291:ALC-1
1145:-rich
1079:myosin
1059:myosin
939:search
937:PubMed
798:P09541
779:P12829
675:Entrez
587:A band
485:BioGPS
423:atrium
64:160770
5098:Talin
5081:MACF1
5049:Other
5008:SPTA1
4873:TEKT5
4868:TEKT4
4863:TEKT3
4858:TEKT2
4853:TEKT1
4836:DCTN1
4819:Other
4673:DNAL4
4668:DNAL1
4658:DNAI2
4653:DNAI1
4618:DNAH9
4613:DNAH8
4608:DNAH7
4603:DNAH6
4598:DNAH5
4593:DNAH3
4588:DNAH2
4583:DNAH1
4564:KIFC3
4559:KIFC2
4554:KIFC1
4549:KIF27
4534:KIF25
4529:KIF24
4524:KIF23
4519:KIF22
4494:KIF19
4479:KIF17
4469:KIF15
4464:KIF14
4449:KIF12
4444:KIF11
4424:KIF5C
4419:KIF5B
4414:KIF5A
4409:KIF4B
4404:KIF4A
4399:KIF3C
4394:KIF3B
4389:KIF2C
4384:KIF2A
4379:KIF1B
4374:KIF1A
4346:MAP1B
4341:MAP1A
4308:TUBE1
4303:TUBD1
4273:TUBG2
4268:TUBG1
4263:TUBB8
4258:TUBB6
4248:TUBB4
4243:TUBB3
4223:TUBB1
4213:TUBA8
3562:Espin
3523:Other
3510:Titin
3316:Other
3305:MYLL1
3300:MYLK2
3290:MYLIP
3275:MYL6B
3208:MYO10
3198:MYO9B
3193:MYO9A
3183:MYO7B
3178:MYO7A
3158:MYO5C
3153:MYO5B
3148:MYO5A
3138:MYO3B
3133:MYO3A
3123:MYH16
3118:MYH15
3113:MYH14
3108:MYH13
3103:MYH11
3098:MYH10
3083:MYH7B
3042:MYO1H
3037:MYO1G
3032:MYO1F
3027:MYO1E
3022:MYO1D
3017:MYO1C
3012:MYO1B
3007:MYO1A
2922:Human
2704:S2CID
2667:S2CID
2274:S2CID
2137:(PDF)
2023:S2CID
1851:S2CID
1300:ACTC1
1155:actin
1126:VLC-1
1111:atria
1075:actin
1067:VLC-1
1063:atria
987:is a
708:17896
668:Mouse
663:Human
634:Amigo
459:fossa
393:blood
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
80:20558
72:97267
5182:ParM
5177:MreB
5172:FtsZ
5132:ACF7
5125:PKP2
5120:PKP1
5103:TLN1
5018:SPTB
4996:ANK3
4991:ANK2
4986:ANK1
4895:DNM3
4890:DNM2
4885:DNM1
4789:PCM1
4439:KIF9
4434:KIF7
4429:KIF6
4356:MAP4
4351:MAP2
4318:MAPs
4218:TUBB
4161:MAPs
4159:and
4100:NEFH
4095:NEFM
4090:NEFL
4049:GFAP
3697:none
3555:FLNC
3550:FLNB
3545:FLNA
3295:MYLK
3285:MYL9
3280:MYL7
3270:MYL6
3265:MYL5
3260:MYL4
3255:MYL3
3250:MYL2
3245:MYL1
3174:VII
3168:MYO6
3129:III
3093:MYH9
3088:MYH8
3078:MYH7
3073:MYH6
3068:MYH4
3063:MYH3
3058:MYH2
3053:MYH1
2935:ABPs
2933:and
2868:PMID
2825:PMID
2782:PMID
2747:PMID
2696:PMID
2659:PMID
2624:PMID
2587:PMID
2552:PMID
2536:Gene
2522:PMID
2493:PMID
2440:PMID
2399:PMID
2356:PMID
2315:PMID
2266:PMID
2230:PMID
2194:PMID
2153:PMID
2115:PMID
2074:PMID
2064:ISBN
2015:PMID
1979:PMID
1930:PMID
1889:PMID
1843:PMID
1808:PMID
1756:PMID
1715:PMID
1674:PMID
1636:PMID
1587:PMID
1543:PMID
1503:PMID
1471:2015
1428:PMID
1305:MYH7
1263:and
1232:and
1203:MYL4
1174:and
1166:and
1115:MYL7
1103:MYL4
1093:and
1033:and
996:gene
993:MYL4
689:4635
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
88:MYL4
60:OMIM
47:MYL4
24:MYL4
4946:GAN
4929:APC
4336:EB3
4331:EB2
4326:EB1
4132:A/C
3815:33B
3810:33A
3214:XV
3189:IX
3164:VI
3049:II
2858:PMC
2850:doi
2815:PMC
2807:doi
2772:doi
2737:PMC
2729:doi
2688:doi
2649:doi
2645:400
2616:doi
2604:221
2577:doi
2573:178
2544:doi
2514:doi
2483:PMC
2475:doi
2430:doi
2391:doi
2379:261
2346:doi
2342:119
2305:PMC
2258:doi
2222:doi
2184:doi
2145:doi
2105:doi
2056:doi
2007:doi
1969:PMC
1961:doi
1957:101
1920:doi
1916:276
1881:doi
1877:449
1835:doi
1831:408
1798:PMC
1790:doi
1746:doi
1742:130
1705:doi
1666:doi
1626:PMC
1618:doi
1577:doi
1573:274
1535:doi
1531:255
1495:doi
1491:211
1418:doi
1414:263
1240:or
1153:of
906:n/a
290:End
189:End
92:OMA
68:MGI
5213::
4142:B2
4137:B1
4130::
4006:80
4001:79
3996:78
3991:77
3986:76
3981:75
3976:74
3971:73
3966:72
3961:71
3945:40
3940:39
3935:28
3930:27
3925:26
3920:25
3915:24
3910:23
3885:86
3880:85
3875:84
3870:83
3865:82
3860:81
3840:38
3835:37
3830:36
3825:35
3820:34
3805:32
3800:31
3757:6C
3752:6B
3747:6A
3727:2A
3702:21
3690:18
3676:20
3671:19
3666:17
3661:16
3656:15
3651:14
3646:13
3641:12
3636:10
3240:LC
3204:X
3144:V
3003:I
2986:G2
2981:G1
2976:C1
2966:A2
2961:A1
2866:.
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