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1 and 2 (HDAC1/2) is induced by the interaction of mSin3A with a multi-protein complex containing HDAC1/2. Transcription is also repressed by histone deacetylase-independent means.
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Wotton D, Knoepfler PS, Laherty CD, Eisenman RN, Massagué J (September 2001). "The Smad transcriptional corepressor TGIF recruits mSin3".
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A 13-Amino Acid
Amphipathic α-Helix Is Required for the Functional Interaction between the Transcriptional Repressor Mad1 and mSin3A
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Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, Urrutia R (August 2001).
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repressor domain that is attached to transcription repressor proteins such as the
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