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Lipotropin

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229:, are all possible fragments of β-lipotropin. β-endorphin is the predominant opioid of the anterior human and rat pituitary gland. Birdsall and Hulme demonstrated that the C-fragment of lipotropin (β-endorphin) has a high affinity for opiate receptors in the brain, and the binding was reversed by naloxone, a classical antagonist of the opiates (Bradbury et al. 1976a). Alongside this, Feldberg found that β-endorphin administered in cat ventricles was 100 times more potent than morphine as an analgesic agent (Feldberg & Smyth 1976, 1977) and the analgesia persisted for several hours. Feldberg concluded that β-endorphin was the most potent analgesic agent known. β-Lipotropin is found in essentially equimolar concentrations to that of 2072: 293:, including weekly administration to players in the 2012 season. The matters are currently under investigation due to the relationship between Lipotropin and growth hormones, as noted by club medical staff. 280:
Lipotropin is on the Prohibited List of substances by the World Anti Doping Agency. Lipotropin has also, under its alternate name AOD-9604 (Anti-Obesity Drug-9604), been connected with controversies in
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peptide fragment of β-lipotropin. In humans, it has 56 amino acids. Gamma lipotropin is identical to the first 56 amino acid sequences of β-lipotropin. It can be cleaved to
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In sheep, gamma-lipotropic hormone is a 58-amino-acid long pituitary polypeptide formed from the first 58 residues of beta-lipotropic hormone. The
44: 2037: 649: 218:. However, no subsequent studies have been published that support these early findings and no receptor has been identified for β-lipotropin. 1957: 1080: 1052: 949: 379:"NH2-terminal amino acid sequence and peptide mapping of purified human beta-lipotropin: comparison with previously proposed sequences" 1583: 908: 290: 49: 1150: 625: 272:β-endorphin has been determined to have an analgesic effect. It produces effects similar to or characteristic of morphine. 2132: 2106: 832: 675: 68: 793: 765: 2142: 1253: 56: 2099: 1947: 827: 1359: 982: 918: 812: 254: 495:
Chrétien M, Lis M, Gilardeau C, Benjannet S (June 1976). "In vitro biosynthesis of gamma-lipotropic hormone".
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of gamma-lipotropic hormone is identical to the structure of beta-melanophore-stimulating hormone.
1402: 531: 2137: 2032: 1569: 1248: 1225: 977: 758: 286: 285:. Allegations have arisen around the use of the drug and its administration to players of the 994: 438:"beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins" 957: 733: 1977: 723: 449: 390: 331: 168: 114: 138: 8: 1834: 1534: 1140: 1135: 1107: 1070: 903: 888: 852: 118: 24: 453: 394: 335: 1666: 1641: 875: 643: 172: 472: 437: 413: 378: 354: 319: 2079: 1671: 1610: 1062: 751: 631: 621: 561: 553: 512: 477: 418: 359: 261: 2087: 1029: 1024: 543: 504: 467: 457: 408: 398: 349: 339: 301:
In 2020 AOD-9604 underwent clinical trials into its use for the treatment of pain.
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
1287: 579: 226: 2126: 1694: 1689: 1656: 1516: 1292: 635: 557: 230: 403: 221:β-Lipotropin can be cleaved into smaller peptides. In humans, γ-lipotropin, 2022: 1898: 1893: 1888: 1883: 1850: 1845: 1596: 1299: 1235: 1220: 1183: 1130: 1097: 837: 804: 565: 462: 344: 1561: 615: 516: 481: 422: 363: 2027: 1937: 1865: 1840: 1776: 1761: 1681: 1651: 1636: 1483: 1460: 962: 865: 617:
The straight dope : the inside story of sport's biggest drug scandal
203: 195: 176: 97: 548: 1829: 1793: 1783: 1766: 1732: 1704: 1661: 1511: 1397: 1047: 999: 923: 250: 238: 234: 199: 192: 92: 2042: 1967: 1952: 1798: 1788: 1771: 1628: 1314: 1243: 1125: 1037: 972: 898: 211: 210:. It was also reported to perform lipid-mobilizing functions such as 665:"Statement of Charges against James Hird and Essendon Football Club" 508: 237:
that can greatly affect mood and behavior and is thus regarded as a
1942: 1921: 1916: 1860: 1465: 1364: 1346: 1304: 1282: 1205: 1197: 1178: 1160: 1089: 967: 860: 822: 222: 1987: 1972: 1592: 1369: 1336: 1331: 1323: 1210: 1145: 1016: 774: 207: 164: 532:"60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective" 73: 1908: 1493: 1455: 1274: 1215: 80: 700: 2071: 1821: 1526: 1501: 1412: 1384: 1117: 494: 743: 2047: 603:
Peptides Direct information page, accessed 26 August 2013
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Spiess J, Mount CD, Nicholson WE, Orth DN (August 1982).
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fragment of POMC. It was initially reported to stimulate
376: 233:. Evidence shows that β-Lipotropin is metabolized into 792: 435: 620:(Updated full story ed.). Carlton, Victoria. 2124: 2038:Pituitary adenylate cyclase-activating peptide 2107: 1958:Cocaine- and amphetamine-regulated transcript 1577: 759: 436:Lazarus LH, Ling N, Guillemin R (June 1976). 1591: 2114: 2100: 1584: 1570: 766: 752: 648:: CS1 maint: location missing publisher ( 179:POMC, which is then cleaved again to form 736:at the U.S. National Library of Medicine 726:at the U.S. National Library of Medicine 547: 471: 461: 412: 402: 353: 343: 613: 317: 291:Essendon Football Club supplements saga 2125: 662: 1565: 747: 529: 267: 2066: 13: 536:Journal of Molecular Endocrinology 296: 14: 2154: 717: 183:(ACTH) and β-lipotropin (β-LPH). 2070: 1254:5-Methoxy-N,N-dimethyltryptamine 497:Canadian Journal of Biochemistry 255:β-melanocyte stimulating hormone 1948:Calcitonin gene-related peptide 693: 275: 244: 186: 16:Peptide hormone in Homo sapiens 656: 607: 596: 572: 523: 488: 429: 370: 311: 1: 318:Li CH, Chung D (April 1976). 304: 2086:. You can help Knowledge by 1963:Delta-sleep-inducing peptide 773: 167:produced by the cleavage of 7: 2133:Genes on human chromosome 2 663:Dillon A (13 August 2013). 10: 2159: 2065: 1422:Insulin-like growth factor 701:"Lateral Pharma | LAT8881" 672:Australian Football League 1983:Gastrin-releasing peptide 1930: 1907: 1876: 1820: 1811: 1754: 1731: 1703: 1680: 1627: 1618: 1603: 1525: 1492: 1474: 1446: 1411: 1383: 1345: 1322: 1313: 1273: 1266: 1234: 1196: 1159: 1116: 1088: 1079: 1061: 1015: 948: 874: 851: 803: 781: 283:Australian Rules Football 144: 134: 129: 125: 108: 103: 91: 79: 67: 55: 43: 35: 30: 23: 738:Medical Subject Headings 728:Medical Subject Headings 584:World Anti Doping Agency 173:anterior pituitary gland 2143:Molecular biology stubs 530:Smyth DG (2016-05-01). 404:10.1073/pnas.79.16.5071 2033:Pancreatic polypeptide 1249:N,N-Dimethyltryptamine 1226:Pancreatic polypeptide 463:10.1073/pnas.73.6.2156 345:10.1073/pnas.73.4.1145 287:Essendon Football Club 580:"The Prohibited List" 191:β-Lipotropin is a 90- 1978:Galanin-like peptide 249:Îł-lipotropin is the 169:pro-opiomelanocortin 163:is the name for two 25:pro-opiomelanocortin 1535:Natriuretic peptide 853:Posterior pituitary 838:Somatostatin (GHIH) 614:Le Grand C (2016). 549:10.1530/JME-16-0033 454:1976PNAS...73.2156L 395:1982PNAS...79.5071S 336:1976PNAS...73.1145L 181:adrenocorticotropin 876:Anterior pituitary 268:Use in pain relief 2095: 2094: 2080:molecular biology 2060: 2059: 2056: 2055: 1807: 1806: 1559: 1558: 1555: 1554: 1442: 1441: 1262: 1261: 1192: 1191: 944: 943: 627:978-0-522-87028-2 262:carboxyl-terminal 158: 157: 154: 153: 2150: 2116: 2109: 2102: 2074: 2067: 1818: 1817: 1625: 1624: 1586: 1579: 1572: 1563: 1562: 1320: 1319: 1315:Digestive system 1271: 1270: 1086: 1085: 1025:Thyroid hormones 801: 800: 790: 789: 768: 761: 754: 745: 744: 734:gamma-Lipotropin 711: 710: 708: 707: 697: 691: 690: 688: 686: 680: 674:. Archived from 669: 660: 654: 653: 647: 639: 611: 605: 600: 594: 593: 591: 590: 576: 570: 569: 551: 527: 521: 520: 492: 486: 485: 475: 465: 433: 427: 426: 416: 406: 374: 368: 367: 357: 347: 315: 200:carboxy-terminal 127: 126: 21: 20: 2158: 2157: 2153: 2152: 2151: 2149: 2148: 2147: 2123: 2122: 2121: 2120: 2063: 2061: 2052: 2008:Neuropeptide VF 2003:Neuropeptide SF 1998:Neuropeptide FF 1993:Neuropeptide AF 1926: 1903: 1872: 1813: 1803: 1750: 1727: 1699: 1676: 1645: 1620:Opioid peptides 1614: 1599: 1590: 1560: 1551: 1521: 1488: 1470: 1438: 1407: 1379: 1341: 1309: 1258: 1230: 1188: 1155: 1112: 1075: 1057: 1041: 1033: 1011: 995:Adrenal medulla 988:Androstenedione 940: 870: 847: 795: 784: 777: 772: 724:beta-Lipotropin 720: 715: 714: 705: 703: 699: 698: 694: 684: 682: 678: 667: 661: 657: 641: 640: 628: 612: 608: 601: 597: 588: 586: 578: 577: 573: 528: 524: 509:10.1139/o76-083 493: 489: 434: 430: 375: 371: 316: 312: 307: 299: 297:Clinical trials 278: 270: 247: 216:steroidogenesis 189: 17: 12: 11: 5: 2156: 2146: 2145: 2140: 2135: 2119: 2118: 2111: 2104: 2096: 2093: 2092: 2075: 2058: 2057: 2054: 2053: 2051: 2050: 2045: 2040: 2035: 2030: 2025: 2020: 2018:Neuropeptide Y 2015: 2013:Neuropeptide S 2010: 2005: 2000: 1995: 1990: 1985: 1980: 1975: 1970: 1965: 1960: 1955: 1950: 1945: 1940: 1934: 1932: 1928: 1927: 1925: 1924: 1919: 1913: 1911: 1905: 1904: 1902: 1901: 1896: 1891: 1886: 1880: 1878: 1874: 1873: 1871: 1870: 1869: 1868: 1863: 1855: 1854: 1853: 1848: 1843: 1832: 1826: 1824: 1815: 1809: 1808: 1805: 1804: 1802: 1801: 1796: 1791: 1786: 1781: 1780: 1779: 1769: 1764: 1758: 1756: 1752: 1751: 1749: 1748: 1746:Leu-enkephalin 1743: 1741:Met-enkephalin 1737: 1735: 1729: 1728: 1726: 1725: 1720: 1715: 1709: 1707: 1701: 1700: 1698: 1697: 1692: 1686: 1684: 1678: 1677: 1675: 1674: 1672:β-Neoendorphin 1669: 1667:α-Neoendorphin 1664: 1659: 1654: 1649: 1648: 1647: 1643: 1633: 1631: 1622: 1616: 1615: 1607: 1605: 1601: 1600: 1589: 1588: 1581: 1574: 1566: 1557: 1556: 1553: 1552: 1550: 1549: 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1002: 992: 991: 990: 985: 980: 975: 970: 965: 958:Adrenal cortex 954: 952: 946: 945: 942: 941: 939: 938: 933: 932: 931: 926: 921: 916: 911: 901: 896: 891: 886: 880: 878: 872: 871: 869: 868: 863: 857: 855: 849: 848: 846: 845: 840: 835: 830: 825: 820: 815: 809: 807: 798: 787: 779: 778: 771: 770: 763: 756: 748: 742: 741: 731: 719: 718:External links 716: 713: 712: 692: 655: 626: 606: 595: 571: 542:(4): T13–T25. 522: 503:(6): 566–570. 487: 428: 389:(16): 5071–5. 369: 309: 308: 306: 303: 298: 295: 277: 274: 269: 266: 251:amino-terminal 246: 243: 188: 185: 156: 155: 152: 151: 146: 142: 141: 136: 132: 131: 123: 122: 112: 106: 105: 101: 100: 95: 89: 88: 83: 77: 76: 71: 65: 64: 59: 53: 52: 47: 41: 40: 37: 33: 32: 28: 27: 15: 9: 6: 4: 3: 2: 2155: 2144: 2141: 2139: 2138:Tumor markers 2136: 2134: 2131: 2130: 2128: 2117: 2112: 2110: 2105: 2103: 2098: 2097: 2091: 2089: 2085: 2082:article is a 2081: 2076: 2073: 2069: 2068: 2064: 2049: 2046: 2044: 2041: 2039: 2036: 2034: 2031: 2029: 2026: 2024: 2021: 2019: 2016: 2014: 2011: 2009: 2006: 2004: 2001: 1999: 1996: 1994: 1991: 1989: 1986: 1984: 1981: 1979: 1976: 1974: 1971: 1969: 1966: 1964: 1961: 1959: 1956: 1954: 1951: 1949: 1946: 1944: 1941: 1939: 1936: 1935: 1933: 1929: 1923: 1920: 1918: 1915: 1914: 1912: 1910: 1906: 1900: 1897: 1895: 1892: 1890: 1887: 1885: 1882: 1881: 1879: 1875: 1867: 1864: 1862: 1859: 1858: 1856: 1852: 1849: 1847: 1844: 1842: 1839: 1838: 1836: 1833: 1831: 1828: 1827: 1825: 1823: 1819: 1816: 1814:neuropeptides 1810: 1800: 1797: 1795: 1792: 1790: 1787: 1785: 1782: 1778: 1775: 1774: 1773: 1770: 1768: 1765: 1763: 1760: 1759: 1757: 1753: 1747: 1744: 1742: 1739: 1738: 1736: 1734: 1730: 1724: 1721: 1719: 1716: 1714: 1711: 1710: 1708: 1706: 1702: 1696: 1695:Endomorphin-2 1693: 1691: 1690:Endomorphin-1 1688: 1687: 1685: 1683: 1679: 1673: 1670: 1668: 1665: 1663: 1660: 1658: 1657:Big dynorphin 1655: 1653: 1650: 1646: 1640: 1639: 1638: 1635: 1634: 1632: 1630: 1626: 1623: 1621: 1617: 1613: 1612: 1606: 1602: 1598: 1597:neuropeptides 1594: 1587: 1582: 1580: 1575: 1573: 1568: 1567: 1564: 1546: 1543: 1541: 1538: 1537: 1536: 1533: 1532: 1530: 1528: 1524: 1518: 1517:Prostaglandin 1515: 1513: 1510: 1508: 1505: 1503: 1500: 1499: 1497: 1495: 1491: 1485: 1482: 1481: 1479: 1477: 1473: 1467: 1464: 1462: 1459: 1457: 1454: 1453: 1451: 1449: 1445: 1433: 1430: 1428: 1425: 1424: 1423: 1420: 1419: 1417: 1414: 1410: 1404: 1401: 1399: 1396: 1394: 1391: 1390: 1388: 1386: 1382: 1376: 1373: 1371: 1368: 1366: 1363: 1361: 1358: 1356: 1353: 1352: 1350: 1348: 1344: 1338: 1335: 1333: 1330: 1329: 1327: 1325: 1321: 1318: 1316: 1312: 1306: 1303: 1301: 1298: 1294: 1291: 1289: 1286: 1285: 1284: 1281: 1280: 1278: 1276: 1272: 1269: 1265: 1255: 1252: 1250: 1247: 1245: 1242: 1241: 1239: 1237: 1233: 1227: 1224: 1222: 1219: 1217: 1214: 1212: 1209: 1207: 1204: 1203: 1201: 1199: 1195: 1185: 1182: 1180: 1177: 1175: 1172: 1170: 1167: 1166: 1164: 1162: 1158: 1152: 1149: 1147: 1144: 1142: 1139: 1137: 1134: 1132: 1129: 1127: 1124: 1123: 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2156–9. 447: 443: 439: 432: 424: 420: 415: 410: 405: 400: 396: 392: 388: 384: 380: 373: 365: 361: 356: 351: 346: 341: 337: 333: 330:(4): 1145–8. 329: 325: 321: 314: 310: 302: 294: 292: 288: 284: 273: 265: 263: 258: 256: 252: 242: 240: 236: 232: 231:corticotropin 228: 224: 219: 217: 213: 209: 205: 201: 197: 194: 184: 182: 178: 175:produces the 174: 171:(POMC). The 170: 166: 162: 150: 147: 143: 140: 137: 133: 128: 124: 121: 120: 116: 113: 111: 107: 102: 99: 96: 94: 90: 87: 84: 82: 78: 75: 72: 70: 66: 63: 60: 58: 54: 51: 48: 46: 42: 38: 34: 29: 26: 22: 19: 2088:expanding it 2077: 2062: 2023:Neurophysins 1851:Neurokinin B 1846:Neurokinin A 1682:Endomorphins 1608: 1300:Thymopoietin 1236:Pineal gland 1221:Somatostatin 1184:Progesterone 1131:Progesterone 1098:Testosterone 1081:Gonadal axis 1053:Thyroid axis 950:Adrenal axis 928: 805:Hypothalamus 704:. Retrieved 695: 683:. Retrieved 676:the original 671: 658: 616: 609: 598: 587:. Retrieved 583: 574: 539: 535: 525: 500: 496: 490: 445: 441: 431: 386: 382: 372: 327: 323: 313: 300: 279: 276:Use in sport 271: 259: 248: 245:Îł-Lipotropin 220: 198:that is the 190: 187:β-Lipotropin 160: 159: 117: 18: 2028:Neurotensin 1938:Angiotensin 1877:Neuromedins 1866:Physalaemin 1841:Substance P 1835:Tachykinins 1830:Bradykinins 1777:Hemorphin-4 1762:Adrenorphin 1733:Enkephalins 1723:Îł-Endorphin 1718:β-Endorphin 1713:α-Endorphin 1652:Dynorphin B 1642:Dynorphin A 1637:Dynorphin A 1484:Osteocalcin 1461:Adiponectin 1288:Thymosin α1 1063:Parathyroid 963:Aldosterone 866:Vasopressin 227:β-endorphin 206:to produce 204:melanocytes 196:polypeptide 177:pro-hormone 139:Swiss-model 31:Identifiers 2127:Categories 1857:amphibian 1794:Spinorphin 1784:Nociceptin 1767:Amidorphin 1705:Endorphins 1662:Leumorphin 1629:Dynorphins 1512:Calcitriol 1398:Peptide YY 1048:Calcitonin 1000:Adrenaline 929:Lipotropin 924:Endorphins 706:2021-03-27 589:2023-11-15 305:References 239:prohormone 235:endorphins 193:amino acid 161:Lipotropin 135:Structures 130:Search for 104:Other data 1968:FMRFamide 1953:Carnosine 1837:: mammal 1799:Valorphin 1789:Opiorphin 1772:Hemorphin 1283:Thymosins 1244:Melatonin 1126:Estradiol 973:Cortisone 899:Prolactin 796:pituitary 783:Endocrine 685:26 August 644:cite book 636:942533247 558:1479-6813 212:lipolysis 86:NM_000939 45:NCBI gene 1943:Bombesin 1861:Kassinin 1611:hormones 1604:Hormones 1593:Peptides 1476:Skeleton 1466:Resistin 1365:Secretin 1347:Duodenum 1305:Thymulin 1206:Glucagon 1198:Pancreas 1179:Estrogen 1161:Placenta 968:Cortisol 861:Oxytocin 823:Dopamine 775:Hormones 566:26903509 165:hormones 149:InterPro 2043:RVD-Hpα 1988:Ghrelin 1973:Galanin 1909:Orexins 1370:Motilin 1337:Ghrelin 1332:Gastrin 1324:Stomach 1211:Insulin 1146:Relaxin 1141:Inhibin 1136:Activin 1108:Inhibin 1017:Thyroid 517:1276982 482:1064883 450:Bibcode 423:6956916 391:Bibcode 364:1063395 332:Bibcode 289:in the 208:melanin 145:Domains 93:UniProt 1822:Kinins 1755:Others 1494:Kidney 1456:Leptin 1415:/other 1275:Thymus 1216:Amylin 1090:Testis 983:DHEA-S 785:glands 740:(MeSH) 730:(MeSH) 634:  624:  564:  556:  515:  480:  473:430469 470:  421:  414:346829 411:  362:  355:430217 352:  225:, and 115:Chr. 2 98:P01189 81:RefSeq 74:176830 36:Symbol 2078:This 1931:Other 1812:Other 1527:Heart 1502:Renin 1432:IGF-2 1427:IGF-1 1413:Liver 1403:GLP-1 1385:Ileum 1267:Other 1151:GnSAF 1118:Ovary 679:(PDF) 668:(PDF) 223:β-MSH 110:Locus 2084:stub 1609:see 978:DHEA 914:ACTH 909:CLIP 904:POMC 833:GHRH 813:GnRH 687:2013 650:link 632:OCLC 622:ISBN 562:PMID 554:ISSN 513:PMID 478:PMID 419:PMID 360:PMID 214:and 69:OMIM 62:9201 57:HGNC 50:5443 39:POMC 2048:VGF 1644:1–8 1545:BNP 1540:ANP 1507:EPO 1375:VIP 1360:GIP 1355:CCK 1174:HPL 1169:hCG 1103:AMH 1071:PTH 919:MSH 894:TSH 884:FSH 843:MCH 828:CRH 818:TRH 544:doi 505:doi 468:PMC 458:doi 409:PMC 399:doi 350:PMC 340:doi 257:. 119:p23 2129:: 1595:: 936:GH 889:LH 670:. 646:}} 642:{{ 630:. 582:. 560:. 552:. 540:56 538:. 534:. 511:. 501:54 499:. 476:. 466:. 456:. 446:73 444:. 440:. 417:. 407:. 397:. 387:79 385:. 381:. 358:. 348:. 338:. 328:73 326:. 322:. 241:. 2115:e 2108:t 2101:v 2090:. 1922:B 1917:A 1899:U 1894:S 1889:N 1884:B 1585:e 1578:t 1571:v 1040:4 1038:T 1032:3 1030:T 767:e 760:t 753:v 709:. 689:. 652:) 638:. 592:. 568:. 546:: 519:. 507:: 484:. 460:: 452:: 425:. 401:: 393:: 366:. 342:: 334::

Index

pro-opiomelanocortin
NCBI gene
5443
HGNC
9201
OMIM
176830
RefSeq
NM_000939
UniProt
P01189
Locus
Chr. 2
p23
Swiss-model
InterPro
hormones
pro-opiomelanocortin
anterior pituitary gland
pro-hormone
adrenocorticotropin
amino acid
polypeptide
carboxy-terminal
melanocytes
melanin
lipolysis
steroidogenesis
β-MSH
β-endorphin

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