51:
initially found by Moore and colleagues as a speckled nuclear antigen present in primary effusion lymphoma cells that reacts with antibodies from patients with KS. It is the most immunodominant KSHV protein identified by
Western-blotting as 222–234 kDa double bands migrate slower than the predicted
157:
and stays on the chromosomes during cell division. It maintains the viral genomes during cell division by tethering the viral episomes to the chromosomes. It binds directly to replication origin recognition complexes (ORCs) that are primarily associated with the terminal repeat (TR) region of the
437:
Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D (August 1996). "The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission".
393:
Gao SJ, Kingsley L, Li M, Zheng W, Parravicini C, Ziegler J, Newton R, Rinaldo CR, Saah A, Phair J, Detels R, Chang Y, Moore PS (August 1996). "KSHV antibodies among
Americans, Italians and Ugandans with and without Kaposi's sarcoma".
611:"Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replication"
346:"The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen"
89:
with an acidic internal repeat domain flanked by a carboxy-terminal domain and an amino-terminal domain. LANA-1 acts as a transcriptional regulator, and it has been implicated directly in
796:"Restricted expression of Epstein-Barr virus (EBV)-encoded, growth transformation-associated antigens in an EBV- and human herpesvirus type 8-carrying body cavity lymphoma line"
657:"Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells"
755:"Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity"
872:"Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen modulates K1 expression through its cis-acting elements within the terminal repeats"
314:
Kellam P, Boshoff C, Whitby D, Matthews S, Weiss RA, Talbot SJ (1997). "Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genome".
706:"Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies"
226:"Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma"
835:
Ballestas ME, Chatis PA, Kaye KM (April 1999). "Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen".
44:
570:"Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus"
85:, LANA-1 is one of few HHV-8 encoded proteins that is highly expressed in all latently infected tumour cells; specifically, it is a
267:"Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus"
82:
56:
expression. It is commonly used as an antigen in blood tests to detect antibodies in persons that have been exposed to KSHV.
481:
Friborg J, Kong W, Hottiger MO, Nabel GJ (1999). "p53 inhibition by the LANA protein of KSHV protects against cell death".
175:
Moore PS, Gao SJ, Dominguez G, Cesarman E, Lungu O, Knowles DM, Garber R, Pellett PE, McGeoch DJ, Chang Y (January 1996).
224:
Gao SJ, Kingsley L, Hoover DR, Spira TJ, Rinaldo CR, Saah A, Phair J, Detels R, Parry P, Chang Y, Moore PS (July 1996).
74:, it invariably expresses high levels of the viral LANA protein, which is necessary and sufficient to maintain the KSHV
62:
or Human herpesvirus 8 (HHV-8) has been identified as the etiological agent of Kaposi’s sarcoma (KS) and certain
754:
795:
138:
transcription factor that interacts with the basic transcription machinery and to bind with two human
52:
molecular weight. LANA has been suspected of playing a crucial role in modulating viral and cellular
124:
105:. This leads to the inactivation of p53-dependent promoters and induction of E2F-dependent genes.
120:
925:
109:
8:
36:
896:
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419:
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681:
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177:"Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma"
848:
771:
116:
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98:
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Jeong JH, Orvis J, Kim JW, McMurtrey CP, Renne R, Dittmer DP (April 2004).
554:
502:
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821:
459:
415:
379:
300:
251:
210:
108:
Studies have also shown that LANA-1 can transactivate the promoter of the
71:
90:
40:
529:"The KSHV latency-associated nuclear antigen: a multifunctional protein"
704:
Schwam DR, Luciano RL, Mahajan SS, Wong L, Wilson AC (September 2000).
451:
407:
147:
139:
113:
282:
154:
67:
655:
Krithivas A, Young DB, Liao G, Greene D, Hayward SD (October 2000).
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93:
because of its ability to bind to the tumour-suppressing protein
75:
48:
143:
128:
344:
Rainbow L, Platt GM, Simpson GR, et al. (August 1997).
527:
Komatsu T, Ballestas ME, Barbera AJ, Kaye KM (March 2002).
526:
313:
135:
63:
53:
869:
870:
Verma SC, Lan K, Choudhuri T, Robertson ES (April 2006).
436:
174:
123:. Paradoxically, LANA-1 has been shown to be involved in
102:
94:
794:
Szekely L, Chen F, Teramoto N, et al. (June 1998).
703:
654:
480:
265:
Kedes DH, Lagunoff M, Renne R, Ganem D (November 1997).
134:
It has been also shown to interact with and inhibit the
264:
567:
223:
834:
793:
343:
70:. As KSHV establishes latent infection in tumorous
392:
127:repression and can, moreover, interact with the
917:
753:Lim C, Sohn H, Gwack Y, Choe J (November 2000).
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119:, thus overextending a critical step in
161:
918:
609:Garber AC, Hu J, Renne R (July 2002).
334:
271:The Journal of Clinical Investigation
615:The Journal of Biological Chemistry
574:The Journal of Biological Chemistry
230:The New England Journal of Medicine
153:LANA-1 is associated with cellular
13:
21:latency-associated nuclear antigen
14:
937:
722:10.1128/JVI.74.18.8532-8540.2000
673:10.1128/JVI.74.20.9637-9645.2000
129:mSin3/HDAC1 co-repressor complex
888:10.1128/JVI.80.7.3445-3458.2006
863:
828:
800:The Journal of General Virology
787:
759:The Journal of General Virology
746:
697:
602:
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362:10.1128/JVI.71.8.5915-5921.1997
142:-associated cellular proteins,
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1:
193:10.1128/JVI.70.1.549-558.1996
849:10.1126/science.284.5414.641
772:10.1099/0022-1317-81-11-2645
7:
813:10.1099/0022-1317-79-6-1445
243:10.1056/NEJM199607253350403
10:
942:
316:Journal of Human Virology
533:Frontiers in Bioscience
121:cellular transformation
628:10.1074/jbc.M203489200
587:10.1074/jbc.M312801200
29:latent nuclear antigen
112:subunit of the human
110:reverse transcriptase
162:Notes and references
876:Journal of Virology
710:Journal of Virology
661:Journal of Virology
350:Journal of Virology
181:Journal of Virology
765:(Pt 11): 2645–52.
452:10.1038/nm0896-918
408:10.1038/nm0896-925
806:(Pt 6): 1445–52.
283:10.1172/JCI119804
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621:(30): 27401–11.
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580:(16): 16822–31.
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539:(1–3): d726–30.
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489:(6764): 889–94.
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37:Kaposi's sarcoma
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843:(5414): 641–4.
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716:(18): 8532–40.
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667:(20): 9637–45.
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546:10.2741/komatsu
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440:Nature Medicine
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277:(10): 2606–10.
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125:transcriptional
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12:
11:
5:
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882:(7): 3445–58.
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827:
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473:
446:(8): 918–924.
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402:(8): 925–928.
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356:(8): 5915–21.
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306:
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236:(4): 233–241.
216:
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158:HHV-8 genome.
99:retinoblastoma
87:phosphoprotein
15:
9:
6:
4:
3:
2:
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322:(1): 19–29.
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66:-associated
59:
58:
39:-associated
32:
28:
24:
20:
18:
97:and to the
91:oncogenesis
81:Encoded by
41:herpesvirus
140:chromosome
136:ATF4/CREB2
117:holoenzyme
114:telomerase
33:LNA, LNA-1
155:chromatin
68:lymphomas
47:) latent
920:Category
906:16537612
857:10213686
781:11038375
740:10954554
691:11000236
637:12015325
596:14742422
555:11861213
503:10622254
468:36556102
424:10275045
328:10195227
101:protein
897:1440413
837:Science
822:9634087
511:4345286
460:8705863
416:8705864
380:9223481
301:9366576
252:8657239
211:8523568
76:episome
49:protein
35:) is a
16:Protein
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731:116365
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371:191847
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292:508462
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209:
202:189843
199:
25:LANA-1
507:S2CID
464:S2CID
420:S2CID
144:MeCP2
83:ORF73
27:) or
902:PMID
853:PMID
818:PMID
777:PMID
736:PMID
687:PMID
633:PMID
592:PMID
551:PMID
499:PMID
456:PMID
412:PMID
376:PMID
324:PMID
297:PMID
248:PMID
207:PMID
146:and
72:foci
64:AIDS
60:KSHV
54:gene
45:KSHV
19:The
892:PMC
884:doi
845:doi
841:284
808:doi
767:doi
726:PMC
718:doi
677:PMC
669:doi
623:doi
619:277
582:doi
578:279
541:doi
491:doi
487:402
448:doi
404:doi
366:PMC
358:doi
287:PMC
279:doi
275:100
238:doi
234:335
197:PMC
189:doi
148:DEK
103:pRb
95:p53
922::
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645:^
631:.
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519:^
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43:(
31:(
23:(
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