218:, where he popularized the idea that any given protein's surrounding environment places constraints upon it, such that the shapes that it can assume are dramatically decreased. Dill introduced a toy model consisting of tethered beads on a lattice to mimic a folding protein, with beads of the same type (i.e. hydrophobic) attracting each other. Mathematically, the folding process can be visualized as a funnel, in which the several unfolded and misfolded high energy states of the protein occupy positions nearer the top of the funnel, but once the protein begins to fold, its options narrow down with the decrease in conformational entropy and the chain rapidly collapses into its most stable, low energy state. This state is sometimes identified with the native state of a natural protein. In Dill's words, "Like skiers all arriving at the same lodge, the folding protein gets systematically closer to the desired protein shape as it moves down the funnel".
202:, studying the biophysical properties of DNA molecules. Towards the end of his doctoral research, he had become interested in the mechanics of protein folding, specifically the way that the RNA-degrading enzyme
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in 2008. He was elected to the
American Academy of Arts and Sciences in 2014. He has been a co-editor or
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where he obtained a S.B. and S.M. in
Mechanical Engineering (1971). He obtained his Ph.D. in 1978 at
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Louis and
Beatrice Laufer Center for Physical and Quantitative Biology
248:(9):3194–3196 (February 28, 2012), DOI: 10.1073/pnas.1200576109, see
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Dill was born in
Oklahoma City, Oklahoma in 1947. He attended
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Members of the United States
National Academy of Sciences
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310:University of California, San Francisco faculty
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320:University of California, San Diego alumni
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355:Fellows of the American Physical Society
241:S. Gupta, 2012, Profile of Ken A. Dill,
216:University of California, San Francisco
198:in the Biology Department working with
72:Hydrophobic-polar protein folding model
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350:Presidents of the Biophysical Society
58:Massachusetts Institute of Technology
261:Rees, Douglas C. (2012). "Preface".
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275:10.1146/annurev-bb-41-050712-100001
62:University of California, San Diego
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168:. He was elected a member of the
315:MIT School of Engineering alumni
305:Stony Brook University faculty
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243:Proc. Natl. Acad. Sci. U.S.A.
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170:National Academy of Sciences
160:. He is the director of the
158:folding pathways of proteins
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263:Annual Review of Biophysics
179:Annual Review of Biophysics
156:best known for his work in
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340:Computational chemists
325:American biophysicists
166:Stony Brook University
122:Stony Brook University
112:Computational Biology
300:Molecular modelling
208:Stanford University
146:Kenneth Austin Dill
82:Max Delbruck Prize
148:(born 1947) is a
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182:since 2013.
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118:Institutions
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335:1947 births
44:Citizenship
20:Ken A. Dill
289:Categories
222:References
104:Chemistry
48:American
37:Oklahoma
176:of the
154:chemist
108:Biology
100:Physics
174:editor
96:Fields
84:(2019)
78:Awards
196:UCSD
186:Life
152:and
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26:Born
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