278:
overturned the widely held “puff bolus” hypothesis, which held that the nicotine from each puff of smoke should generate a spike in brain nicotine uptake within 10 seconds. In fact, the lung serves as a depot for nicotine, releasing the dose over several minutes. This new understanding of brain nicotine pharmacokinetics has implications both for the understanding of mechanisms underlying nicotine addiction as well as development of more effective nicotine replacement strategies.
212:, M.D., Ph.D. and K. Daniel Rose in the early 1980s. Rose et al. published the first study of the pharmacokinetics of a transdermal nicotine patch in humans in 1984 and the subsequently filed US Patent 4920989 which was upheld in a priority decision in 1993. This work helped pave the way for the development of commercial nicotine skin patches.
287:
changes in pharmacotherapy for patch non-responders. Rose continues to develop personalized approaches to smoking cessation treatment based on smokers’ characteristics, including level of nicotine dependence, and genomic markers, which he helped to identify in the first genome-wide association studies of smoking cessation treatment outcome.
259:
Rose aided in the conception of varenicline for smoking cessation: In the 1990s Rose et al. conducted clinical trials of an agonist-antagonist combination treatment, using nicotine (agonist) and mecamylamine (nicotinic antagonist). The combination proved more efficacious than either agent alone.
286:
Rose validated the first adaptive treatment algorithm for smoking cessation: Rose led a series of studies showing that the initial response to pre-cessation administration of nicotine skin patch treatment predicted long-term abstinence. Subsequently, this response was used to implement adaptive
268:
Rose demonstrated the role of nicotine and non-nicotine sensory factors in tobacco addiction: In a series of studies, Rose et al. dissociated non-nicotine factors, including sensory cues accompanying cigarette inhalation, from the pharmacologic effects of nicotine. Attenuating these cues, while
942:
Rose JE. Transdermal nicotine as a strategy for nicotine replacement. In: The
Pharmacologic Treatment of Tobacco Dependence: Proceedings of the World Congress, November 4–5, 1985, edited by JK Ockene. Cambridge, MA: Institute for the Study of Smoking Behavior and Policy, pp. 158–166,
225:
His first NIDA-funded grant, “Scaling the
Reinforcing Value of Cigarette Smoke” (1981-2000), measured the role of nicotine in tobacco dependence, by selectively varying nicotine concentrations in smoke while holding tar yield constant, using a two-barreled smoke-mixing device. This method was
277:
Rose elucidated the brain pharmacokinetics of inhaled nicotine: Rose et al. conducted the first direct assessment of the rate of brain nicotine uptake during cigarette smoking, using cigarettes spiked with the radiotracer nicotine and PET scanning to image nicotine in the brain. The results
2013:
McKinney, DL; Gogova, M; Davies, BD; Ramakrishnan, V; Fisher, K; Carter, WH; Karnes, HT; Garnett, WR; Iyer, SS; Somani, AA; Kobal, G; Barr, WH (2012). "Evaluation of the effect of ammonia on nicotine pharmacokinetics using rapid arterial sampling".
247:: In the early 1980s, he led the initial exploration of transdermal nicotine administration for smoking cessation. In a series of studies he and colleagues showed that transdermal nicotine administration reduced craving for
260:
Pfizer pharmaceuticals cited this work as helping to inspire the development of the partial nicotinic agonist varenicline, which is currently the most effective pharmacologic smoking cessation treatment available.
269:
holding nicotine intake constant, significantly reduced the psychological rewarding and satiating effects of cigarette smoke. Conversely, presenting sensory inhalational cues down-regulated smoking behavior.
1097:
1563:
Westman, EC; Behm, FM; Rose, JE (1995). "Airway sensory replacement combined with nicotine replacement for smoking cessation. A randomized, placebo-controlled trial using a citric acid inhaler".
700:
Westman, EC; Behm, FM; Rose, JE (1995). "Airway sensory replacement combined with nicotine replacement for smoking cessation: A randomized, placebo controlled trial using a citric acid inhaler".
170:
is an
American academic professor, inventor and researcher in the field of nicotine and smoking cessation. Rose is presently the President and CEO of the Rose Research Center, LLC in Raleigh,
1335:
Rose, JE; Behm, FM; Westman, EC; Levin, ED; Stein, RM; Ripka, GV (1994). "Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone".
737:
Rose, JE; Behm, FM; Westman, EC; Levin, ED; Stein, RM; Ripka, GV (1994). "Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone".
1933:
479:
Rose, JE; Herskovic, JE; Behm, FM; Westman, EC (2009). "Pre-cessation treatment with nicotine patch significantly increases abstinence rates relative to conventional treatment".
2232:
Rose, JE; Herskovic, JE; Behm, FM; Westman, EC (2009). "Precessation treatment with nicotine patch significantly increases abstinence rates relative to conventional treatment".
640:
Rose, JE; Behm, FM; Westman, EC; Coleman, RE (1999). "Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: Implications for addiction".
2340:
222:
Also in the 1980s, Rose developed novel methods for reaerosolizing selected constituents of tobacco smoke in cigarette-sized devices, a forerunner of modern e-cigarettes.
774:
Rose, JE; Behm, FM; Westman, EC; Levin, ED; Stein, RM; Lane, JD; Ripka, GV (1994). "Combined effects of nicotine and mecamylamine in attenuating smoking reward".
251:
and that it was efficacious for smoking cessation. Rose experimented on himself, applying nicotine to his skin and measuring his body's physiological responses.
1606:
Rose, JE; Westman, EC; Behm, FM; Johnson, MP; Goldberg, JS (1999). "Blockade of smoking satisfaction using the peripheral nicotinic antagonist trimethaphan".
603:
Rose, JE; Westman, EC; Behm, FM; Johnson, MP; Goldberg, JS (1999). "Blockade of smoking satisfaction using the peripheral nicotinic antagonist trimethaphan".
2370:
1378:
Rose, JE; Behm, FM; Westman, EC (2001). "Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking".
2365:
2360:
2345:
574:
Brauer, LH; Behm, FM; Lane, JD; Westman, EC; Perkins, C; Rose, JE (2001). "Individual differences in smoking reward from denicotinized cigarettes".
1770:
Coe, JW; Brooks, PR; Vetelino, MG; et al. (May 2005). "Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation".
2335:
2136:"Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances"
1071:
671:
2134:
Uhl, G. R.; Walther, D.; Musci, R.; Fisher, C.; Anthony, J. C.; Storr, C. L.; Behm, F. M.; Eaton, W. W.; Ialongo, N.; Rose, J. E. (2014).
428:"Kinetics of brain nicotine accumulation in dependent and non-dependent smokers assessed with PET and cigarettes containing 11C-nicotine"
1956:"Kinetics of brain nicotine accumulation in dependent and nondependent smokers assessed with PET and cigarettes containing 11C-nicotine"
1421:
Rose, JE; Behm, FM; Westman, EC (1998). "Nicotine-mecamylamine treatment for smoking cessation: the role of pre-cessation therapy".
669:
Rose, JE; Behm, FM; Westman, EC (1998). "Nicotine/mecamylamine treatment for smoking cessation: the role of pre-cessation therapy".
984:
Rose, JE; Herskovic, JE; Trilling, Y; Jarvik, ME (1985). "Transdermal nicotine reduces cigarette craving and nicotine preference".
2321:
832:
Rose, JE; Levin, ED (1992). "Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence".
1737:
Rose, Jed E.; Levin, Edward D.; Behm, Frederique M.; Westman, Eric C.; Stein, Roy M.; Lane, James D.; Ripka, Gail V. (1994).
194:
55:
1835:"Effectiveness of pharmacologic therapies on smoking cessation success: three years results of a smoking cessation clinic"
1649:
190:
50:
1954:
Rose, J. E.; Mukhin, A. G.; Lokitz, S. J.; Turkington, T. G.; Herskovic, J.; Behm, F. M.; Garg, S.; Garg, P. K. (2010).
186:
45:
1709:
1118:
795:
Rose, JE; Behm, FM; Levin, ED (1993). "The role of nicotine dose and sensory cues in the regulation of smoke intake".
1520:
Rose, JE; Behm, FM; Levin, ED (1993). "Role of nicotine dose and sensory cues in the regulation of smoke intake".
2185:"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score"
2057:
385:"Personalized smoking cessation: interactions between nicotine dose, dependence and quit success genotype score"
174:. Additionally, he is the Director of the Duke Center for Smoking Cessation at Duke University Medical Center.
143:
215:
Rose is also responsible for studying agonist-antagonist treatments that provided support for the development
1289:
1263:
1237:
2385:
1186:
947:
Rose, JE; Tashkin, DP; Ertle, A; Zinser, MC; Lafer, R (1985). "Sensory blockade of smoking satisfaction".
1813:
869:
Rose, JE; Levin, ED; Behm, F; Adivi, C (1990). "Transdermal nicotine facilitates smoking cessation".
426:
Rose, JE; Mukhin, AG; Lokitz, SJ; Turkington, TG; Herskovic, J; Behm, FM; Garg, S; Garg, PK (2010).
2087:"Adapting smoking cessation treatment according to initial response to precessation nicotine patch"
1075:
2071:
2269:"Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm"
1165:
299:"Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm"
2375:
226:
employed in research cited in the 1988 U.S. Surgeon
General's Report on nicotine addiction.
2380:
1967:
906:
Rose, JE; Behm, FM (1987). "Refined cigarette smoke as a means to reduce nicotine intake".
439:
342:"Adapting quit-smoking treatment based on initial response to pre-cessation nicotine patch"
1315:"Nicotine–mecamylamine treatment for smoking cessation: The role of pre-cessation therapy"
1211:
8:
1478:"The Health Consequences of Smoking: Nicotine Addiction: A Report of the Surgeon General"
1971:
443:
2293:
2268:
2209:
2184:
2160:
2135:
2111:
2086:
2039:
1990:
1955:
1910:
1885:
1861:
1834:
1833:
Yilmazel Ucar, E; Araz, O; Yilmaz, N; Akgun, M; Meral, M; Kaynar, H; Saglam, L (2014).
1795:
1631:
1588:
1545:
1403:
1360:
1009:
972:
931:
894:
857:
820:
762:
725:
628:
562:
508:
Rose, JE (2007). "Multiple brain pathways and receptor subtypes in tobacco addiction".
462:
427:
409:
384:
366:
341:
323:
298:
114:
1619:
1391:
653:
616:
2318:
2298:
2249:
2214:
2165:
2116:
2031:
1995:
1915:
1866:
1818:
1787:
1691:
1687:
1674:
Rose, JE; Jarvik, ME; Rose, KD (May 1984). "Transdermal administration of nicotine".
1623:
1580:
1537:
1533:
1456:
1438:
1395:
1352:
1038:
1034:
1001:
964:
960:
923:
919:
886:
849:
845:
812:
808:
754:
717:
688:
657:
620:
591:
566:
554:
525:
496:
467:
414:
371:
328:
244:
2043:
1799:
1592:
1549:
1407:
1364:
1013:
976:
935:
861:
824:
766:
729:
2288:
2284:
2280:
2241:
2204:
2196:
2155:
2147:
2106:
2102:
2098:
2023:
1985:
1975:
1905:
1897:
1856:
1846:
1779:
1750:
1683:
1635:
1615:
1572:
1529:
1430:
1387:
1344:
1030:
993:
956:
915:
898:
878:
841:
804:
783:
746:
709:
680:
649:
632:
612:
583:
546:
517:
488:
457:
447:
404:
396:
361:
357:
353:
318:
314:
310:
1290:"Method and apparatus for aiding in the reduction of incidence of tobacco smoking"
1098:"Method and apparatus for aiding in the reduction of incidence of tobacco smoking"
2325:
1314:
1021:
Rose, JE; Jarvik, ME; Rose, KD (1984). "Transdermal administration of nicotine".
1886:"Reinforcing effects of nicotine and non-nicotine components of cigarette smoke"
1739:"Combined Agonist-Antagonist Treatment for Nicotine and Other Drug Dependencies"
240:
205:
171:
74:
2200:
1901:
1653:
1499:
1434:
787:
684:
550:
521:
400:
2354:
1576:
713:
209:
1980:
537:
Rose, JE (2006). "Nicotine and nonnicotine factors in cigarette addiction".
452:
2302:
2253:
2218:
2169:
2120:
2035:
1999:
1919:
1870:
1791:
1755:
1738:
1477:
1399:
1122:
661:
595:
587:
558:
529:
500:
471:
418:
375:
332:
281:
119:
2058:"Smokers Double Their Quit Rate By Wearing Nicotine Patch Before Stopping"
1851:
1695:
1627:
1584:
1541:
1442:
1356:
1348:
1042:
1005:
997:
968:
927:
890:
853:
816:
758:
750:
721:
692:
624:
2245:
2027:
882:
492:
216:
2151:
1212:"Murray Jarvik, 84, Whose Research Helped Lead to Nicotine Patch, Dies"
248:
1783:
2330:
1714:
1710:"Believe It or Not, Big Tobacco May Help Make Anti-Addiction Drugs"
2012:
1934:"Duke nicotine research conference examines tobacco addiction"
1884:
Rose, JE; Salley, A; Behm, FM; Bates, JE; Westman, EC (2010).
1457:"Refined cigarette smoke as a means to reduce nicotine intake"
1832:
983:
135:
2183:
Rose, JE; Behm, FM; Drgon, T; Johnson, C; Uhl, GR (2010).
1953:
1144:
425:
383:
Rose, JE; Behm, FM; Drgon, T; Johnson, C; Uhl, GR (2010).
185:
Rose received his undergraduate bachelor's degree at the
140:
Nicotine
Research Laboratory, VA Medical Center Brentwood
2231:
478:
282:
First adaptive treatment algorithm for smoking cessation
263:
254:
229:
1605:
946:
639:
602:
2133:
2072:"Nicotine Patch Before Quitting Doubles Success Rate"
573:
272:
2182:
1736:
1334:
773:
736:
382:
1883:
182:Jed Eugene Rose was born on June 8, 1952, in Ohio.
868:
1769:
1255:
2352:
1065:
1063:
1061:
1059:
1960:Proceedings of the National Academy of Sciences
1562:
1420:
1377:
699:
668:
432:Proceedings of the National Academy of Sciences
1673:
1205:
1203:
1020:
189:. He later went on to obtain his Ph.D. at the
1519:
1414:
1371:
1328:
1307:
1229:
1056:
794:
2371:University of California, Los Angeles alumni
2341:Patents invented and co-invented by Jed Rose
1090:
776:Experimental and Clinical Psychopharmacology
672:Experimental and Clinical Psychopharmacology
1702:
1281:
1200:
2366:University of California, San Diego alumni
1763:
1500:"Sensory blockade of smoking satisfaction"
1449:
1179:
199:
193:and finished his PostDoctoral work at the
2361:University of California, Berkeley alumni
2292:
2208:
2159:
2110:
1989:
1979:
1909:
1860:
1850:
1754:
1158:
831:
461:
451:
408:
365:
322:
2266:
2084:
1264:"Transdermal administration of nicotine"
905:
339:
296:
290:
204:Rose is most known for co-inventing the
2127:
2064:
2050:
2006:
1947:
1877:
1826:
1806:
1730:
1667:
1642:
1137:
1111:
1072:"Duke Medical Center Faculty Directory"
2353:
2260:
2225:
2078:
1926:
1238:"Invention of the Nicotine Skin Patch"
986:Clinical Pharmacology and Therapeutics
949:Pharmacology Biochemistry and Behavior
908:Pharmacology Biochemistry and Behavior
871:Clinical Pharmacology and Therapeutics
834:Pharmacology Biochemistry and Behavior
797:Pharmacology Biochemistry and Behavior
739:Clinical Pharmacology and Therapeutics
605:Pharmacology Biochemistry and Behavior
239:Rose initiated the development of the
2176:
1599:
1556:
1513:
1492:
1209:
195:University of California, Los Angeles
56:University of California, Los Angeles
2336:Nicotine Skin Patch Patent US4920989
1470:
536:
507:
264:Sensory factors in tobacco addiction
255:Inspiring the development of Chantix
230:Significant contributions to science
1145:"Duke Center for Smoking Cessation"
191:University of California, San Diego
51:University of California, San Diego
13:
1288:Ii, Thomas H. Maugh (2008-05-14).
1287:
1262:Ii, Thomas H. Maugh (2008-05-14).
1261:
1236:Ii, Thomas H. Maugh (2008-05-14).
1235:
273:First radiotracer nicotine studies
187:University of California, Berkeley
46:University of California, Berkeley
14:
2397:
2312:
234:
148:Duke Center for Smoking Cessation
1069:
177:
576:Nicotine & Tobacco Research
481:Nicotine & Tobacco Research
2285:10.1176/appi.ajp.2014.13050595
2103:10.1176/appi.ajp.2013.12070919
1650:"Better World Project Article"
1166:"Jed Eugene Rose Birth Record"
358:10.1176/appi.ajp.2013.12070919
346:American Journal of Psychiatry
315:10.1176/appi.ajp.2014.13050595
303:American Journal of Psychiatry
144:Duke University Medical Center
1:
2331:The Rose Research Center, LLC
1620:10.1016/s0091-3057(98)00153-1
1392:10.1016/s0091-3057(00)00465-2
1050:
654:10.1016/s0376-8716(99)00025-3
617:10.1016/s0091-3057(98)00153-1
1688:10.1016/0376-8716(84)90061-9
1534:10.1016/0091-3057(93)90021-k
1187:"Murray E. Jarvik, Obituary"
1035:10.1016/0376-8716(84)90061-9
961:10.1016/0091-3057(85)90572-6
920:10.1016/0091-3057(87)90229-2
846:10.1016/0091-3057(92)90086-u
809:10.1016/0091-3057(93)90021-k
7:
2267:Rose, JE; Behm, FM (2014).
2085:Rose, JE; Behm, FM (2013).
1676:Drug and Alcohol Dependence
1210:Weber, Bruce (2008-05-13).
1023:Drug and Alcohol Dependence
642:Drug and Alcohol Dependence
340:Rose, JE; Behm, FM (2013).
297:Rose, JE; Behm, FM (2014).
10:
2402:
2201:10.2119/molmed.2009.00159
1902:10.1007/s00213-010-1810-2
1435:10.1037/1064-1297.6.3.331
788:10.1037/1064-1297.2.4.328
685:10.1037/1064-1297.6.3.331
551:10.1007/s00213-005-0250-x
522:10.1016/j.bcp.2007.07.039
401:10.2119/molmed.2009.00159
161:
151:Rose Research Center, LLC
128:
104:
97:
89:
67:
38:
28:
21:
1814:"Ready to Quit Smoking?"
1577:10.1378/chest.107.5.1358
1423:Exp Clin Psychopharmacol
714:10.1378/chest.107.5.1358
510:Biochemical Pharmacology
1981:10.1073/pnas.0909184107
1743:Neuropsychopharmacology
1608:Pharmacol Biochem Behav
1522:Pharmacol Biochem Behav
1380:Pharmacol Biochem Behav
453:10.1073/pnas.0909184107
200:Inventions and research
1839:Multidiscip Respir Med
1756:10.1038/sj.npp.1380199
1119:"Rose Research Center"
588:10.1080/14622200123249
2346:Dr. Rose Publications
1852:10.1186/2049-6958-9-9
1349:10.1038/clpt.1994.105
998:10.1038/clpt.1985.203
751:10.1038/clpt.1994.105
291:Selected publications
2319:Duke Faculty Website
2140:Molecular Psychiatry
1078:on 19 September 2016
883:10.1038/clpt.1990.35
2386:American scientists
2152:10.1038/mp.2012.155
1972:2010PNAS..107.5190R
1822:. 16 February 2009.
1337:Clin Pharmacol Ther
444:2010PNAS..107.5190R
206:nicotine skin patch
111:Nicotine Dependence
2324:2016-03-09 at the
2246:10.1093/ntr/ntp103
2028:10.1093/ntr/ntr257
1890:Psychopharmacology
1216:The New York Times
539:Psychopharmacology
493:10.1093/ntr/ntp103
389:Molecular Medicine
115:Psychopharmacology
1966:(11): 5190–5195.
1819:Los Angeles Times
1784:10.1021/jm050069n
1294:Los Angeles Times
1268:Los Angeles Times
1242:Los Angeles Times
245:smoking cessation
165:
164:
99:Scientific career
82:Nicotine Research
79:Nicotine Pyruvate
16:American academic
2393:
2307:
2306:
2296:
2279:(11): 1199–205.
2264:
2258:
2257:
2234:Nicotine Tob Res
2229:
2223:
2222:
2212:
2180:
2174:
2173:
2163:
2131:
2125:
2124:
2114:
2082:
2076:
2075:
2068:
2062:
2061:
2054:
2048:
2047:
2016:Nicotine Tob Res
2010:
2004:
2003:
1993:
1983:
1951:
1945:
1944:
1942:
1940:
1930:
1924:
1923:
1913:
1881:
1875:
1874:
1864:
1854:
1830:
1824:
1823:
1810:
1804:
1803:
1767:
1761:
1760:
1758:
1734:
1728:
1727:
1725:
1723:
1706:
1700:
1699:
1671:
1665:
1664:
1662:
1661:
1652:. Archived from
1646:
1640:
1639:
1603:
1597:
1596:
1560:
1554:
1553:
1517:
1511:
1510:
1508:
1506:
1496:
1490:
1489:
1487:
1485:
1474:
1468:
1467:
1465:
1463:
1453:
1447:
1446:
1418:
1412:
1411:
1375:
1369:
1368:
1332:
1326:
1325:
1323:
1321:
1311:
1305:
1304:
1302:
1300:
1285:
1279:
1278:
1276:
1274:
1259:
1253:
1252:
1250:
1248:
1233:
1227:
1226:
1224:
1222:
1207:
1198:
1197:
1195:
1193:
1183:
1177:
1176:
1174:
1172:
1162:
1156:
1155:
1153:
1151:
1141:
1135:
1134:
1132:
1130:
1125:on 27 April 2016
1121:. Archived from
1115:
1109:
1108:
1106:
1104:
1094:
1088:
1087:
1085:
1083:
1074:. Archived from
1067:
1046:
1017:
980:
939:
902:
865:
828:
791:
770:
733:
708:(5): 1358–1364.
696:
665:
636:
599:
570:
545:(3–4): 274–285.
533:
516:(8): 1263–1270.
504:
487:(9): 1067–1075.
475:
465:
455:
422:
412:
379:
369:
336:
326:
309:(11): 1199–205.
19:
18:
2401:
2400:
2396:
2395:
2394:
2392:
2391:
2390:
2351:
2350:
2326:Wayback Machine
2315:
2310:
2273:Am J Psychiatry
2265:
2261:
2230:
2226:
2195:(7–8): 247–53.
2181:
2177:
2132:
2128:
2091:Am J Psychiatry
2083:
2079:
2070:
2069:
2065:
2056:
2055:
2051:
2011:
2007:
1952:
1948:
1938:
1936:
1932:
1931:
1927:
1882:
1878:
1831:
1827:
1812:
1811:
1807:
1768:
1764:
1735:
1731:
1721:
1719:
1708:
1707:
1703:
1672:
1668:
1659:
1657:
1648:
1647:
1643:
1604:
1600:
1561:
1557:
1518:
1514:
1504:
1502:
1498:
1497:
1493:
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