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Hypokalemia

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561:, while in type A intercalated cells protons are secreted via both H-KATPases and H ATP-ases on the apical/luminal surface of the cell. By definition, the H-KATPase reabsorbs one potassium ion into the cell for every proton it secretes into the lumen of the collecting duct of a nephron. In addition, when H is expelled from the cell (by HATP-ase), cations—in this case potassium—are taken up by the cell in order to maintain electroneutrality (but not through direct exchange as with the H-KATPase). In order to correct the pH during alkalosis, these cells will use these mechanisms to reabsorb great amounts of H, which will concomitantly increase their intracellular concentrations of potassium. This concentration gradient drives potassium to be secreted across the apical surface of the cell into the tubular lumen through potassium channels (this facilitated diffusion occurs in both Type B intercalated cells and Principal cells in the collecting duct). 925:, or stopping an offending medication. People without a significant source of potassium loss and who show no symptoms of hypokalemia may not require treatment. Acutely, repletion with 10 mEq of potassium is typically expected to raise serum potassium by 0.1 mEq/L immediately after administration. However, for those with chronic hypokalemia, repletion takes time due to tissue redistribution. For example, correction by 1 mEq/L can take more than 1000 mEq of potassium over many days. 1079:. When peripheral infusions are necessary, the burning can be reduced by diluting the potassium in larger amounts of fluid, or adding a small dose of lidocaine to the intravenous fluid, although adding lidocaine may increase the likelihood of medical errors. Even in severe hypokalemia, oral supplementation is preferred given its safety profile. Sustained-release formulations should be avoided in acute settings. 42: 1205:
Soar J, Perkins GD, Abbas G, Alfonzo A, Barelli A, Bierens JJ, Brugger H, Deakin CD, Dunning J, Georgiou M, Handley AJ, Lockey DJ, Paal P, Sandroni C, Thies KC, Zideman DA, Nolan JP (October 2010). "European Resuscitation Council Guidelines for Resuscitation 2010 Section 8. Cardiac arrest in special
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Meanwhile, the daily body requirement of potassium is calculated by multiplying 1 mmol to body weight in kilograms. Adding potassium deficit and daily potassium requirement would give the total amount of potassium need to be corrected in mmol. Dividing mmol by 13.4 will give the potassium in
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that may occur due to vomiting, diuretic therapy, or nasogastric drainage. Additionally, replacing potassium solely through diet may be costly and result in weight gain due to potentially large amounts of food needed. An effort should also be made to limit dietary sodium intake due to an inverse
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Pseudohypokalemia is a decrease in the amount of potassium that occurs due to excessive uptake of potassium by metabolically active cells in a blood sample after it has been drawn. It is a laboratory artifact that may occur when blood samples remain in warm conditions for several hours before
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can also lead to hypokalemia due to excess cortisol binding the Na/K pump and acting like aldosterone. Hypertension and hypokalemia can also be seen with a deficiency of the 11-beta-hydroxysteroid dehydrogenase type 2 enzyme which allows cortisols to stimulate aldosterone receptors. This
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In the heart, hypokalemia causes arrhythmias because of less-than-complete recovery from sodium-channel inactivation, making the triggering of an action potential less likely. In addition, the reduced extracellular potassium (paradoxically) inhibits the activity of the
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Eating potassium-rich foods may not be sufficient for correcting low potassium; potassium supplements may be recommended. Potassium contained in foods is almost entirely coupled with phosphate and is thus ineffective in correcting hypokalemia associated with
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The earliest ECG findings, associated with hypokalemia, are decreased T wave height. Then, ST depressions and T inversions appear as serum potassium levels reduce further. Due to prolonged repolarization of ventricular
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solution is used, with 20–40 meq/L KCl per liter over 3–4 hours. Giving IV potassium at faster rates (20–25 meq/hr) may inadvertently expose the heart to a sudden increase in potassium, potentially causing dangerous
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Potassium chloride supplements by mouth have the advantage of containing precise quantities of potassium, but the disadvantages of a taste which may be unpleasant, and the potential for side-effects including
878:, prominent U waves occur (usually seen at V2 and V3 leads), frequently superimposed upon T waves, therefore producing the appearance of prolonged QT intervals, when serum potassium levels fall below 3 mEq/L. 277:. If given intravenously, potassium is generally replaced at rates of less than 20 mmol/hour. Solutions containing high concentrations of potassium (>40 mmol/L) should generally be given using a 2117:
Sodi R, Davison AS, Holmes E, Hine TJ, Roberts NB (June 2009). "The phenomenon of seasonal pseudohypokalemia: effects of ambient temperature, plasma glucose and role for sodium-potassium-exchanging-ATPase".
273:. Potassium levels that are only slightly below the normal range can be managed with changes in the diet. Lower levels of potassium require replacement with supplements either taken by mouth or given 655:, can cause hypokalemia, in a manner similar to that of diuretics. As opposed to disease states of primary excesses of aldosterone, blood pressure is either normal or low in Bartter's or Gitelman's. 371:
from severe impairment of skeletal muscle function is found in some people. Psychological symptoms associated with severe hypokalemia can include delirium, hallucinations, depression, or psychosis.
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Mild hypokalemia (>3.0 mEq/L) may be treated by eating potassium-containing foods or by taking potassium chloride supplements in a tablet or syrup form (by mouth supplements). Foods rich in
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activity. The electrochemical gradient of potassium between the intracellular and extracellular space is essential for nerve function; in particular, potassium is needed to repolarize the
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is required for adequate processing of potassium. This may become evident when hypokalemia persists despite potassium supplementation. Other electrolyte abnormalities may also be present.
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In addition to alkalosis, other factors can cause transient shifting of potassium into cells, presumably by stimulation of the Na/K pump. These hormones and medications include
258:) with levels below 3.5 mmol/L defined as hypokalemia. It is classified as severe when levels are less than 2.5 mmol/L. Low levels may also be suspected based on an 1206:
circumstances: Electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution".
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can precipitate occasional attacks of severe hypokalemia and muscle weakness. These defects cause a heightened sensitivity to the normal changes in potassium produced by
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A more common cause is excessive loss of potassium, often associated with heavy fluid losses that flush potassium out of the body. Typically, this is a consequence of
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centers around the setting's scarcity of available potassium, and the resulting deficiency and its effects on the world's colonists and their society.
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a diet with enough potassium-containing foods or fasting can cause the gradual onset of hypokalemia. This is a rare cause and may occur in those with
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Shirley DG, Walter SJ, Noormohamed FH (November 2002). "Natriuretic effect of caffeine: assessment of segmental sodium reabsorption in humans".
2778: 2476: 2327: 499:. Hypokalemia is observed with low total body potassium and a low intracellular concentration of potassium. In addition to urinary losses from 1067:. Faster infusion rates are therefore generally only performed in locations in which the heart rhythm can be continuously monitored such as a 431:
can also cause hypokalemia, although not much potassium is lost from the vomitus. Rather, heavy urinary losses of K in the setting of post-
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Kraft MD, Btaiche IF, Sacks GS, Kudsk KA (2005-08-15). "Treatment of electrolyte disorders in adult patients in the intensive care unit".
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Whyte KF, Addis GJ, Whitesmith R, Reid JL (April 1987). "Failure of chronic theophylline therapy to alter circulating catecholamines".
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A handful of published reports describe individuals with severe hypokalemia related to chronic extreme consumption (4–10 L/day) of
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Mascolo M, Chu ES, Mehler PS (April 2011). "Abuse and clinical value of diuretics in eating disorders therapeutic applications".
829:. As a result, a greater-than-normal stimulus is required for depolarization of the membrane to initiate an action potential. 817:
has passed. Lower potassium levels in the extracellular space cause hyperpolarization of the resting membrane potential. This
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Zieg J, Gonsorcikova L, Landau D (July 2016). "Current views on the diagnosis and management of hypokalaemia in children".
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relationship with serum potassium. Increasing magnesium intake may also be beneficial for similar physiological reasons.
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2) Metabolic alkalosis is often present in states of volume depletion, such as vomiting, so potassium is also lost via
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The speed at which potassium should be replaced depends on whether or not there are symptoms or abnormalities on an
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Krishna GG, Miller E, Kapoor S (1989). "Increased blood pressure during potassium depletion in normotensive men".
1107:. Concomitant hypomagnesemia will inhibit potassium replacement, as magnesium is a cofactor for potassium uptake. 3535: 3503: 3307: 3249: 3126: 2994: 2982: 289: 2096: 1075:
is encouraged to avoid the occurrence of a burning sensation at the site of infusion, or the rare occurrence of
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potassium current and delays ventricular repolarization. This delayed repolarization may promote
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Hypokalemia which is recurrent or resistant to treatment may be amenable to a potassium-sparing
3395: 3187: 2543: 1339: 791: 368: 250:, and not enough intake in the diet. Normal potassium levels in humans are between 3.5 and 5.0 75: 2880: 2505: 2279: 1490: 1370: 3555: 3488: 3356: 3192: 2948: 2307: 1031: 616: 596: 2738: 1516: 3466: 3460: 3452: 3437: 3418: 3090: 3067: 2989: 1144: 516: 8: 3669: 3572: 3560: 3550: 2891: 2829: 1068: 787: 732:, which lead to movement of potassium from the extracellular fluid into the muscle cells. 477: 274: 270: 1219: 49:
An ECG in a person with a potassium level of 1.1 meq/L showing the classical changes of
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levels can cause hypertension and excessive urinary losses of potassium. These include
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concentration (caused by vomiting, for example) will exceed the capacity of the renal
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Khan E, Spiers C, Khan M (March 2013). "The heart and potassium: a banana republic".
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Content of Selected Foods per Common Measure, sorted by nutrient content (Potassium)
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can also cause long-term hypokalemia. Diuretic abuse among athletes and people with
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occurring with profound hypokalemia with serum potassium levels less than 2 meq/L.
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with levels below 3.5 mmol/L (less than 3.5 mEq/L) defined as hypokalemia.
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changes (PR prolongation, ST-segment and T-wave depression, U-wave formation).
522: 481: 400: 364: 324: 247: 216: 145: 111: 2856: 2819: 2720:"Narrative review: evolving concepts in potassium homeostasis and hypokalemia" 2048:
Packer, C.D. (June 2009). "Cola-induced hypokalaemia: a super-sized problem".
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Treatment includes addressing the cause, such as improving the diet, treating
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The amount of potassium deficit can be calculated using the following formula:
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Rare hereditary defects of muscular ion channels and transporters that cause
465: 352: 340: 191:. Mild low potassium does not typically cause symptoms. Symptoms may include 2691:. In David A. Warrell, Timothy M. Cox, John D. Firth, Graham S. Ogg (eds.). 2529: 1456: 3518: 3493: 3447: 3241: 3182: 3121: 2905: 2756: 2623: 2603: 2433: 2393: 2264: 2177: 2139: 2069: 2026: 1983: 1942: 1925: 1908: 1893: 1828: 1639: 1604: 1475: 1309: 1227: 690: 625: 540: 420: 416: 360: 348: 320: 263: 204: 95: 1842:
Charach G, Karniel E, Grosskopf I, Rabinovich A, Charach L (2 July 2020).
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Pathy MJ (2006). "Appendix 1: Conversion of SI Units to Standard Units".
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Greenlee M, Wingo, CS, McDonough, AA, Youn, JH, Kone, BC (May 5, 2009).
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Taal MW, Chertow GM, Marsden PA, Skorecki K, Yu AS, Brenner BM (2011).
1104: 998: 950: 694: 682: 678: 644: 480:) commonly cause hypokalemia. Other medications such as the antifungal 469: 227: 125: 50: 2802: 2717: 2018: 1631: 1301: 3113: 2886: 1092: 1076: 1002: 934: 686: 629: 536: 526: 507:, also an obligate loss of potassium from kidney tubules occurs as a 485: 282: 184: 166:
Dietary changes, potassium supplements, based on the underlying cause
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Cadwallader AB, De La Torre X, Tieri A, Botrè F (September 2010).
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Certain medications can cause excess potassium loss in the urine.
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Mild hypokalemia is often without symptoms, although it may cause
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is caused by the effect of the altered potassium gradient on
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and copious fluid intake, although it may also be related to
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P & T: A Peer-Reviewed Journal for Formulary Management
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Rosen's Emergency Medicine - Concepts and Clinical Practice
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may present with hypokalemia due to urinary potassium loss.
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Potassium is essential for many body functions, including
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Jain VV, Gupta OP, Jajoo SU, Khiangate B (January 2011).
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is preferred when correcting hypokalemia associated with
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Cohn JN, Kowey PR, Whelton PK, Prisant LM (2000-09-11).
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3) During metabolic alkalosis, the acute rise of plasma
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into the urine via a number of interrelated mechanisms.
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bicarbonaturia force urinary potassium excretion. (See
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that means high level of potassium in the blood serum.
2411: 1344:(8 ed.). Elsevier Health Sciences. p. 1639. 1287: 624:—can either be congenital or caused by consumption of 2788:
National Organization for Rare Disorders: Hypokalemia
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Originally published as "Excessive Candor" no. 48 in
2116: 2792: 1538:"Hypokalemia and Psychosis: A Forgotten Association" 1041: 1517:"Symptoms and Signs of Low Potassium (Hypokalemia)" 1402: 1337: 2312:: CS1 maint: DOI inactive as of September 2024 ( 1956:Tsimihodimos V, Kakaidi V, Elisaf M (June 2009). 1542:American Journal of Psychiatry Residents' Journal 928: 379:Hypokalemia can result from one or more of these 3651: 1617: 854:Normal potassium levels are between 3.5 and 5.0 584:, and potassium will be excreted as an obligate 406: 2776:List of foods rich in potassium (U. Mass. Med.) 2701:10.1093/med/9780199204854.003.210202_update_001 1046:Severe hypokalemia (<3.0 mEq/L) may require 2155: 1909:"Unusual causes of hypokalaemia and paralysis" 1082: 386: 207:. Low potassium also increases the risk of an 3226: 2933: 1722: 1681: 1246:Principles and Practice of Geriatric Medicine 495:A special case of potassium loss occurs with 35:Hypokalaemia, hypopotassaemia, hypopotassemia 2047: 709:) can also cause hypokalemia by stimulating 647:defects of renal salt transporters, such as 591:Disease states that lead to abnormally high 2277: 1792: 1723:Halperin ML, Kamel KS (1998). "Potassium". 1652: 1646: 782:About 98% of the body's potassium is found 3233: 3219: 2947: 2940: 2926: 2556: 2414:American Journal of Health-System Pharmacy 2228: 2090: 2050:International Journal of Clinical Practice 1962:International Journal of Clinical Practice 660:Distribution away from extracellular fluid 622:apparent mineralocorticoid excess syndrome 2746: 2658:"Review of Destiny's Road by Larry Niven" 2383: 2254: 1973: 1924: 1883: 1818: 1699: 1620:International Journal of Eating Disorders 1594: 1553: 1495:. Elsevier Health Sciences. p. 618. 1465: 1455: 1375:. Elsevier Health Sciences. p. 487. 1333: 1331: 1329: 1327: 1239: 1237: 1200: 1198: 1196: 1194: 1192: 1190: 1716: 1655:Human Physiology: An Integrated Approach 1188: 1186: 1184: 1182: 1180: 1178: 1176: 1174: 1172: 1170: 327:, and can provoke the development of an 222:Causes of hypokalemia include vomiting, 2739:10.7326/0003-4819-150-9-200905050-00008 1906: 1368: 1283: 1281: 1279: 1277: 1275: 1273: 3652: 1492:Brenner and Rector's The Kidney E-Book 1338:Marx J, Walls R, Hockberger R (2013). 1324: 1234: 1115:The plot of the science fiction novel 288:Hypokalemia is one of the most common 3214: 2921: 2686: 2601: 2500: 2407: 2405: 2403: 2361: 2359: 2357: 2355: 2151: 2149: 1682:Walmsley RN, White GH (August 1984). 1243: 1167: 1150:Potassium deficiency (plant disorder) 523:A low level of magnesium in the blood 314: 3035:Familial hypocalciuric hypercalcemia 2689:"Disorders of potassium homeostasis" 1535: 1440:"Hypokalemia induced rhabdomyolysis" 1398: 1396: 1372:The Human Body in Health and Illness 1270: 866:Hypokalemia leads to characteristic 861: 766: 262:(ECG). The opposite state is called 158:Blood potassium < 3.5 mmol/L 3151:Hypokalemic sensory overstimulation 2514:. Harold Wood, London, UK: Beccon. 2210:from the original on 1 October 2016 1405:The New England Journal of Medicine 1220:10.1016/j.resuscitation.2010.08.015 1155:Superior mesenteric artery syndrome 937:include dried fruits (particularly 628:, which is contained in extract of 16:Insufficient potassium in the blood 13: 2680: 2400: 2352: 2146: 2095:. Health.yahoo.com. Archived from 1110: 777: 537:An increase in the pH of the blood 285:replacement may also be required. 174:20% of people admitted to hospital 14: 3686: 2764: 2132:10.1016/j.clinbiochem.2009.01.024 1793:Veltri KT, Mason C (March 2015). 1393: 1042:Intravenous potassium replacement 794:is maintained principally by the 355:). With more severe hypokalemia, 3240: 2062:10.1111/j.1742-1241.2009.02066.x 1975:10.1111/j.1742-1241.2009.02051.x 1795:"Medication-induced hypokalemia" 1587:10.1111/j.1476-5381.2010.00789.x 1389:from the original on 2016-10-01. 1358:from the original on 2016-08-15. 603:(generally nonmalignant) of the 343:(owing to disturbed function of 40: 3127:Hyperkalemic periodic paralysis 2995:Disorders of calcium metabolism 2650: 2595: 2550: 2494: 2440: 2320: 2284:New England Journal of Medicine 2271: 2222: 2192: 2110: 2084: 2041: 1998: 1949: 1900: 1835: 1786: 1759: 1684:"Occult causes of hypokalaemia" 1675: 1611: 1575:British Journal of Pharmacology 1562: 1555:10.1176/appi.ajp-rj.2016.111103 1529: 454: 148:, not enough intake in the diet 3198:Cerebral salt-wasting syndrome 3146:Hypokalemic periodic paralysis 2328:"Sources of Dietary Potassium" 2278:Ingelfinger JR (1 July 2015). 1509: 1482: 1431: 1362: 1050:supplementation. Typically, a 993:, citrus fruits (particularly 929:Oral potassium supplementation 718:hypokalemic periodic paralysis 436: 1: 2372:Archives of Internal Medicine 2292:10.1056/feature.2015.06.16.43 2200:"Potassium (Unit Conversion)" 1907:Alazami M (8 February 2006). 1737:10.1016/S0140-6736(98)85044-7 1160: 407:Gastrointestinal or skin loss 363:may result. Reports exist of 2385:10.1001/archinte.160.16.2429 2231:"ECG Diagnosis: Hypokalemia" 2170:10.3109/17482941.2012.741250 1444:Indian Journal of Nephrology 916: 844: 813:to a resting state after an 786:, with the remainder in the 525:can also cause hypokalemia. 351:(from disturbed function of 290:water–electrolyte imbalances 7: 3308:Wernicke–Korsakoff syndrome 3000:Hypercalcemia of malignancy 2727:Annals of Internal Medicine 2693:Oxford Textbook of Medicine 2566:The Universe of Larry Niven 1860:10.1097/MD.0000000000020931 1417:10.1056/NEJM198905043201804 1128: 1083:Potassium-sparing diuretics 588:partner to the bicarbonate. 387:Inadequate potassium intake 61:, and a slightly prolonged 10: 3691: 2602:Niven L (17 August 2010). 1701:10.1093/clinchem/30.8.1406 1030:and abdominal discomfort. 957:, leafy green vegetables, 909:) × body weight (kg) × 0.4 823:resting membrane potential 790:including the blood. This 557:reabsorb H and secrete HCO 462:Blood pressure medications 3616: 3581: 3479: 3410: 3313:Wernicke's encephalopathy 3287: 3278: 3248: 3161: 3112: 3089: 3066: 3043: 2955: 2866: 2796: 2584:review from the July 1997 2511:Scores: Reviews 1993–2003 2091:HealthGuru (2012-03-01). 881: 513:negatively charged ketone 419:, losses associated with 374: 170: 162: 152: 117: 105: 81: 69: 48: 39: 31: 26: 3660:Electrolyte disturbances 3029:Dystrophic calcification 3025:Metastatic calcification 1254:10.1002/047009057X.app01 949:cereals and wheat germ, 849: 736: 2759:. NIHMSID: NIHMS800438. 2664:(Blog). 26 January 2013 1653:Silverthorn DU (2016). 1457:10.4103/0971-4065.78085 437:discussion of alkalosis 279:central venous catheter 2949:Electrolyte imbalances 2544:Science Fiction Weekly 2235:The Permanente Journal 1057:abnormal heart rhythms 792:concentration gradient 640:, and chewing tobacco. 369:Respiratory depression 76:Critical care medicine 3489:Electrolyte imbalance 3357:Pyridoxine deficiency 3331:Riboflavin deficiency 2547:no. 48, 16 June 1997. 2294:(inactive 2024-09-12) 1032:Potassium bicarbonate 839:reentrant arrhythmias 632:, sometimes found in 597:renal artery stenosis 567:-mediated mechanisms. 497:diabetic ketoacidosis 329:abnormal heart rhythm 209:abnormal heart rhythm 100:abnormal heart rhythm 53:depression, inverted 3665:Mineral deficiencies 3467:Vitamin K deficiency 3461:Vitamin E deficiency 3438:Vitamin D deficiency 3419:Vitamin A deficiency 3318:Korsakoff's syndrome 2990:Milk-alkali syndrome 1926:10.1093/qjmed/hcl011 1661:. pp. 646–647. 1145:Hypokalemic acidosis 620:deficiency—known as 447:and the presence of 2974:Symptoms and signs 2589:Science Fiction Age 2572:on 22 November 2019 788:extracellular fluid 545:interstitial fluids 484:or the cancer drug 478:hydrochlorothiazide 445:pancreatic fistulae 425:surgical procedures 226:, medications like 124:, medications like 3481:Mineral deficiency 3280:Vitamin deficiency 2867:External resources 2781:2017-01-03 at the 2426:10.2146/ajhp040300 2247:10.7812/tpp/12-015 2229:Levi's JT (2012). 2158:Acute Cardiac Care 2093:"Health.yahoo.com" 1369:Herlihy B (2014). 1077:damage to the vein 1069:critical care unit 1036:metabolic acidosis 900:normal lower limit 825:as defined by the 634:herbal supplements 617:Cushing's syndrome 613:hyperaldosteronism 551:intercalated cells 505:volume contraction 474:thiazide diuretics 315:Signs and symptoms 244:hyperaldosteronism 240:diabetes insipidus 183:is a low level of 142:hyperaldosteronism 138:diabetes insipidus 3647: 3646: 3596:Failure to thrive 3591:Delayed milestone 3475: 3474: 3453:Harrison's groove 3383:Folate deficiency 3370:Biotin deficiency 3208: 3207: 2915: 2914: 2710:978-0-19-920485-4 2521:978-1-870824-47-7 2420:(16): 1663–1682. 2340:on 3 January 2017 2019:10.1042/cs1030461 1668:978-0-321-98122-6 1659:Pearson Education 1632:10.1002/eat.20814 1502:978-1-4557-2304-1 1382:978-1-4557-5642-1 1351:978-1-4557-4987-4 1302:10.1111/apa.13398 1263:978-0-470-09055-8 1140:Gitelman syndrome 1013:, and red meats. 862:Electrocardiogram 819:hyperpolarization 767:Pseudohypokalemia 653:Gitelman syndrome 580:to reabsorb this 517:β-hydroxybutyrate 357:flaccid paralysis 309:'blood condition' 271:electrocardiogram 260:electrocardiogram 211:, which is often 178: 177: 154:Diagnostic method 21:Medical condition 3682: 3285: 3284: 3235: 3228: 3221: 3212: 3211: 3015:Calcinosis cutis 2942: 2935: 2928: 2919: 2918: 2794: 2793: 2760: 2750: 2724: 2714: 2687:Firth J (2010). 2674: 2673: 2671: 2669: 2654: 2648: 2647: 2641: 2637: 2635: 2627: 2599: 2593: 2581: 2579: 2577: 2568:. Archived from 2562:"Destiny's Road" 2554: 2548: 2540: 2538: 2536: 2498: 2492: 2491: 2489: 2488: 2479:. Archived from 2473: 2467: 2466: 2464: 2463: 2454:. Archived from 2444: 2438: 2437: 2409: 2398: 2397: 2387: 2363: 2350: 2349: 2347: 2345: 2339: 2332: 2324: 2318: 2317: 2311: 2303: 2301: 2299: 2275: 2269: 2268: 2258: 2226: 2220: 2219: 2217: 2215: 2196: 2190: 2189: 2153: 2144: 2143: 2114: 2108: 2107: 2105: 2104: 2088: 2082: 2081: 2045: 2039: 2038: 2002: 1996: 1995: 1977: 1953: 1947: 1946: 1928: 1904: 1898: 1897: 1887: 1839: 1833: 1832: 1822: 1790: 1784: 1783: 1768:Eur J Respir Dis 1763: 1757: 1756: 1731:(9122): 135–40. 1720: 1714: 1713: 1703: 1679: 1673: 1672: 1657:(7th ed.). 1650: 1644: 1643: 1615: 1609: 1608: 1598: 1566: 1560: 1559: 1557: 1533: 1527: 1526: 1524: 1523: 1513: 1507: 1506: 1486: 1480: 1479: 1469: 1459: 1435: 1429: 1428: 1400: 1391: 1390: 1366: 1360: 1359: 1335: 1322: 1321: 1290:Acta Paediatrica 1285: 1268: 1267: 1241: 1232: 1231: 1202: 1135:Bartter syndrome 910: 827:Goldman equation 815:action potential 758:caused by heavy 711:beta-2 receptors 649:Bartter syndrome 490:eating disorders 441:gastrointestinal 397:anorexia nervosa 44: 24: 23: 3690: 3689: 3685: 3684: 3683: 3681: 3680: 3679: 3650: 3649: 3648: 3643: 3612: 3577: 3471: 3406: 3399: 3392: 3379: 3366: 3353: 3340: 3327: 3299: 3274: 3251: 3244: 3239: 3209: 3204: 3157: 3108: 3085: 3062: 3039: 2951: 2946: 2916: 2911: 2910: 2862: 2861: 2805: 2783:Wayback Machine 2767: 2722: 2711: 2683: 2681:Further reading 2678: 2677: 2667: 2665: 2656: 2655: 2651: 2639: 2638: 2629: 2628: 2616: 2600: 2596: 2575: 2573: 2560:(8 June 1997). 2555: 2551: 2534: 2532: 2522: 2499: 2495: 2486: 2484: 2475: 2474: 2470: 2461: 2459: 2446: 2445: 2441: 2410: 2401: 2378:(16): 2429–36. 2364: 2353: 2343: 2341: 2337: 2330: 2326: 2325: 2321: 2305: 2304: 2297: 2295: 2276: 2272: 2227: 2223: 2213: 2211: 2198: 2197: 2193: 2154: 2147: 2115: 2111: 2102: 2100: 2089: 2085: 2046: 2042: 2003: 1999: 1954: 1950: 1905: 1901: 1840: 1836: 1791: 1787: 1764: 1760: 1721: 1717: 1680: 1676: 1669: 1651: 1647: 1616: 1612: 1567: 1563: 1536:Hong E (2016). 1534: 1530: 1521: 1519: 1515: 1514: 1510: 1503: 1487: 1483: 1436: 1432: 1411:(18): 1177–82. 1401: 1394: 1383: 1367: 1363: 1352: 1336: 1325: 1286: 1271: 1264: 1242: 1235: 1214:(10): 1400–33. 1203: 1168: 1163: 1131: 1113: 1111:Popular culture 1085: 1044: 931: 919: 911: 908: 901: 894: 888: 887: 884: 876:Purkinje fibers 864: 852: 847: 836: 780: 778:Pathophysiology 769: 739: 730:thyroid hormone 703:methylphenidate 662: 609:Conn's syndrome 578:proximal tubule 574: 568: 562: 560: 555:collecting duct 548: 511:partner to the 457: 443:causes include 409: 389: 377: 345:skeletal muscle 333:muscle weakness 317: 22: 17: 12: 11: 5: 3688: 3678: 3677: 3672: 3667: 3662: 3645: 3644: 3642: 3641: 3636: 3631: 3626: 3620: 3618: 3614: 3613: 3611: 3610: 3609: 3608: 3598: 3593: 3587: 3585: 3579: 3578: 3576: 3575: 3570: 3569: 3568: 3566:Keshan disease 3558: 3553: 3548: 3543: 3538: 3533: 3528: 3523: 3522: 3521: 3516: 3511: 3506: 3501: 3496: 3485: 3483: 3477: 3476: 3473: 3472: 3470: 3469: 3463: 3457: 3456: 3455: 3450: 3445: 3434: 3428: 3427: 3426: 3414: 3412: 3408: 3407: 3405: 3404: 3403: 3402: 3397: 3390: 3387: 3386: 3385: 3377: 3374: 3373: 3372: 3364: 3361: 3360: 3359: 3351: 3348: 3347: 3346: 3338: 3335: 3334: 3333: 3325: 3322: 3321: 3320: 3315: 3310: 3305: 3297: 3293: 3291: 3282: 3276: 3275: 3273: 3272: 3267: 3262: 3256: 3254: 3250:Protein-energy 3246: 3245: 3238: 3237: 3230: 3223: 3215: 3206: 3205: 3203: 3202: 3201: 3200: 3195: 3190: 3180: 3179: 3178: 3176:Salt poisoning 3167: 3165: 3159: 3158: 3156: 3155: 3154: 3153: 3148: 3138: 3137: 3136: 3135: 3134: 3118: 3116: 3110: 3109: 3107: 3106: 3101: 3095: 3093: 3087: 3086: 3084: 3083: 3078: 3072: 3070: 3064: 3063: 3061: 3060: 3055: 3049: 3047: 3041: 3040: 3038: 3037: 3032: 3018: 3004: 3003: 3002: 2992: 2987: 2986: 2985: 2983:Trousseau sign 2980: 2972: 2967: 2961: 2959: 2953: 2952: 2945: 2944: 2937: 2930: 2922: 2913: 2912: 2909: 2908: 2897: 2892:article/242008 2883: 2871: 2870: 2868: 2864: 2863: 2860: 2859: 2848: 2837: 2822: 2806: 2801: 2800: 2798: 2797:Classification 2791: 2790: 2785: 2773: 2766: 2765:External links 2763: 2762: 2761: 2715: 2709: 2682: 2679: 2676: 2675: 2649: 2640:|website= 2614: 2605:Destiny's road 2594: 2549: 2520: 2493: 2468: 2452:www.sps.nhs.uk 2439: 2399: 2351: 2319: 2270: 2221: 2191: 2145: 2109: 2083: 2040: 1997: 1948: 1919:(3): 181–192. 1899: 1854:(27): e20931. 1834: 1805:(3): 185–190. 1785: 1758: 1715: 1674: 1667: 1645: 1626:(3): 200–202. 1610: 1561: 1528: 1508: 1501: 1481: 1430: 1392: 1381: 1361: 1350: 1323: 1269: 1262: 1233: 1165: 1164: 1162: 1159: 1158: 1157: 1152: 1147: 1142: 1137: 1130: 1127: 1118:Destiny's Road 1112: 1109: 1101:spironolactone 1084: 1081: 1043: 1040: 930: 927: 918: 915: 906: 899: 892: 883: 880: 863: 860: 851: 848: 846: 843: 834: 779: 776: 775: 774: 768: 765: 764: 763: 738: 735: 734: 733: 722:catecholamines 714: 661: 658: 657: 656: 641: 607:glands, e.g., 589: 572: 558: 531: 530: 520: 493: 482:amphotericin B 466:loop diuretics 456: 453: 439:below.) Other 408: 405: 401:ketogenic diet 399:or those on a 388: 385: 376: 373: 365:rhabdomyolysis 339:, tremor, and 325:blood pressure 316: 313: 304:'potassium' + 248:hypomagnesemia 217:cardiac arrest 215:and can cause 176: 175: 172: 168: 167: 164: 160: 159: 156: 150: 149: 146:hypomagnesemia 119: 115: 114: 112:Cardiac arrest 109: 103: 102: 85: 79: 78: 73: 67: 66: 46: 45: 37: 36: 33: 29: 28: 20: 15: 9: 6: 4: 3: 2: 3687: 3676: 3673: 3671: 3668: 3666: 3663: 3661: 3658: 3657: 3655: 3640: 3637: 3635: 3632: 3630: 3627: 3625: 3622: 3621: 3619: 3615: 3607: 3604: 3603: 3602: 3601:Short stature 3599: 3597: 3594: 3592: 3589: 3588: 3586: 3584: 3580: 3574: 3571: 3567: 3564: 3563: 3562: 3559: 3557: 3554: 3552: 3549: 3547: 3544: 3542: 3539: 3537: 3534: 3532: 3529: 3527: 3524: 3520: 3517: 3515: 3512: 3510: 3507: 3505: 3502: 3500: 3497: 3495: 3492: 3491: 3490: 3487: 3486: 3484: 3482: 3478: 3468: 3464: 3462: 3458: 3454: 3451: 3449: 3446: 3444: 3441: 3440: 3439: 3435: 3433: 3429: 3425: 3424:Bitot's spots 3422: 3421: 3420: 3416: 3415: 3413: 3409: 3401: 3394: 3393: 3388: 3384: 3381: 3380: 3375: 3371: 3368: 3367: 3362: 3358: 3355: 3354: 3349: 3345: 3342: 3341: 3336: 3332: 3329: 3328: 3323: 3319: 3316: 3314: 3311: 3309: 3306: 3304: 3301: 3300: 3295: 3294: 3292: 3290: 3286: 3283: 3281: 3277: 3271: 3268: 3266: 3263: 3261: 3258: 3257: 3255: 3253: 3247: 3243: 3236: 3231: 3229: 3224: 3222: 3217: 3216: 3213: 3199: 3196: 3194: 3191: 3189: 3186: 3185: 3184: 3181: 3177: 3174: 3173: 3172: 3169: 3168: 3166: 3164: 3160: 3152: 3149: 3147: 3144: 3143: 3142: 3139: 3133: 3130: 3129: 3128: 3125: 3124: 3123: 3120: 3119: 3117: 3115: 3111: 3105: 3102: 3100: 3097: 3096: 3094: 3092: 3088: 3082: 3079: 3077: 3074: 3073: 3071: 3069: 3065: 3059: 3056: 3054: 3051: 3050: 3048: 3046: 3042: 3036: 3033: 3030: 3026: 3022: 3021:Calcification 3019: 3016: 3012: 3011:Calciphylaxis 3008: 3005: 3001: 2998: 2997: 2996: 2993: 2991: 2988: 2984: 2981: 2979: 2978:Chvostek sign 2976: 2975: 2973: 2971: 2968: 2966: 2963: 2962: 2960: 2958: 2954: 2950: 2943: 2938: 2936: 2931: 2929: 2924: 2923: 2920: 2907: 2903: 2902: 2898: 2896: 2893: 2889: 2888: 2884: 2882: 2878: 2877: 2873: 2872: 2869: 2865: 2858: 2854: 2853: 2849: 2847: 2843: 2842: 2838: 2836: 2832: 2831: 2827: 2823: 2821: 2817: 2816: 2812: 2808: 2807: 2804: 2799: 2795: 2789: 2786: 2784: 2780: 2777: 2774: 2772: 2769: 2768: 2758: 2754: 2749: 2744: 2740: 2736: 2733:(9): 619–25. 2732: 2728: 2721: 2716: 2712: 2706: 2702: 2698: 2694: 2690: 2685: 2684: 2663: 2659: 2653: 2645: 2633: 2625: 2621: 2617: 2615:9780312851224 2611: 2607: 2606: 2598: 2591: 2590: 2585: 2582:Reprints the 2571: 2567: 2563: 2559: 2553: 2546: 2545: 2531: 2527: 2523: 2517: 2513: 2512: 2507: 2503: 2497: 2483:on 2008-12-22 2482: 2478: 2472: 2458:on 2018-10-16 2457: 2453: 2449: 2443: 2435: 2431: 2427: 2423: 2419: 2415: 2408: 2406: 2404: 2395: 2391: 2386: 2381: 2377: 2373: 2369: 2362: 2360: 2358: 2356: 2336: 2329: 2323: 2315: 2309: 2293: 2289: 2285: 2281: 2274: 2266: 2262: 2257: 2252: 2248: 2244: 2240: 2236: 2232: 2225: 2209: 2205: 2201: 2195: 2187: 2183: 2179: 2175: 2171: 2167: 2163: 2159: 2152: 2150: 2141: 2137: 2133: 2129: 2125: 2121: 2120:Clin. Biochem 2113: 2099:on 2009-06-12 2098: 2094: 2087: 2079: 2075: 2071: 2067: 2063: 2059: 2055: 2051: 2044: 2036: 2032: 2028: 2024: 2020: 2016: 2012: 2008: 2001: 1993: 1989: 1985: 1981: 1976: 1971: 1967: 1963: 1959: 1952: 1944: 1940: 1936: 1932: 1927: 1922: 1918: 1914: 1910: 1903: 1895: 1891: 1886: 1881: 1877: 1873: 1869: 1865: 1861: 1857: 1853: 1849: 1845: 1838: 1830: 1826: 1821: 1816: 1812: 1808: 1804: 1800: 1796: 1789: 1781: 1777: 1773: 1769: 1762: 1754: 1750: 1746: 1742: 1738: 1734: 1730: 1726: 1719: 1711: 1707: 1702: 1697: 1694:(8): 1406–8. 1693: 1689: 1685: 1678: 1670: 1664: 1660: 1656: 1649: 1641: 1637: 1633: 1629: 1625: 1621: 1614: 1606: 1602: 1597: 1592: 1588: 1584: 1580: 1576: 1572: 1565: 1556: 1551: 1547: 1543: 1539: 1532: 1518: 1512: 1504: 1498: 1494: 1493: 1485: 1477: 1473: 1468: 1463: 1458: 1453: 1449: 1445: 1441: 1434: 1426: 1422: 1418: 1414: 1410: 1406: 1399: 1397: 1388: 1384: 1378: 1374: 1373: 1365: 1357: 1353: 1347: 1343: 1342: 1334: 1332: 1330: 1328: 1319: 1315: 1311: 1307: 1303: 1299: 1296:(7): 762–72. 1295: 1291: 1284: 1282: 1280: 1278: 1276: 1274: 1265: 1259: 1255: 1251: 1247: 1240: 1238: 1229: 1225: 1221: 1217: 1213: 1209: 1208:Resuscitation 1201: 1199: 1197: 1195: 1193: 1191: 1189: 1187: 1185: 1183: 1181: 1179: 1177: 1175: 1173: 1171: 1166: 1156: 1153: 1151: 1148: 1146: 1143: 1141: 1138: 1136: 1133: 1132: 1126: 1124: 1120: 1119: 1108: 1106: 1102: 1098: 1094: 1090: 1080: 1078: 1074: 1070: 1066: 1062: 1058: 1053: 1049: 1039: 1037: 1033: 1029: 1023: 1020: 1019:hypochloremia 1014: 1012: 1008: 1004: 1000: 996: 992: 991:coconut water 988: 984: 980: 976: 972: 968: 964: 963:winter squash 960: 956: 952: 948: 944: 940: 936: 926: 924: 914: 905: 898: 895:(in mmol) = ( 891: 879: 877: 871: 869: 859: 857: 842: 840: 830: 828: 824: 820: 816: 812: 811:cell membrane 808: 804: 799: 797: 793: 789: 785: 771: 770: 761: 757: 753: 749: 745: 741: 740: 731: 727: 723: 719: 715: 712: 708: 704: 700: 696: 692: 688: 684: 680: 676: 675:beta agonists 672: 668: 664: 663: 654: 650: 646: 642: 639: 635: 631: 627: 623: 618: 614: 610: 606: 602: 598: 594: 590: 587: 583: 579: 575: 566: 556: 552: 546: 542: 538: 535: 534: 533: 528: 524: 521: 518: 514: 510: 506: 502: 498: 494: 491: 487: 483: 479: 475: 471: 467: 463: 459: 458: 452: 450: 446: 442: 438: 434: 430: 426: 422: 418: 414: 404: 402: 398: 394: 384: 382: 372: 370: 366: 362: 358: 354: 353:smooth muscle 350: 346: 342: 341:muscle cramps 338: 334: 330: 326: 322: 312: 310: 308: 303: 299: 295: 291: 286: 284: 280: 276: 275:intravenously 272: 267: 265: 261: 257: 254:(3.5 and 5.0 253: 249: 245: 241: 237: 233: 229: 225: 220: 218: 214: 210: 206: 202: 198: 194: 193:feeling tired 190: 186: 182: 173: 169: 165: 161: 157: 155: 151: 147: 143: 139: 135: 131: 127: 123: 120: 116: 113: 110: 108: 107:Complications 104: 101: 97: 93: 89: 88:Feeling tired 86: 84: 80: 77: 74: 72: 68: 64: 60: 56: 52: 47: 43: 38: 34: 30: 25: 19: 3513: 3448:Osteomalacia 3252:malnutrition 3242:Malnutrition 3140: 2899: 2885: 2874: 2850: 2839: 2824: 2809: 2730: 2726: 2692: 2666:. Retrieved 2661: 2652: 2604: 2597: 2587: 2574:. Retrieved 2570:the original 2565: 2558:Di Filippo P 2552: 2542: 2533:. Retrieved 2510: 2506:"Wiser Book" 2496: 2485:. Retrieved 2481:the original 2471: 2460:. Retrieved 2456:the original 2451: 2442: 2417: 2413: 2375: 2371: 2342:. Retrieved 2335:the original 2322: 2308:cite journal 2296:. Retrieved 2283: 2273: 2238: 2234: 2224: 2214:27 September 2212:. Retrieved 2203: 2194: 2164:(1): 17–24. 2161: 2157: 2126:(9): 813–8. 2123: 2119: 2112: 2101:. Retrieved 2097:the original 2086: 2056:(6): 833–5. 2053: 2049: 2043: 2013:(5): 461–6. 2010: 2006: 2000: 1968:(6): 900–2. 1965: 1961: 1951: 1916: 1912: 1902: 1851: 1847: 1837: 1802: 1798: 1788: 1774:(4): 221–8. 1771: 1767: 1761: 1728: 1724: 1718: 1691: 1687: 1677: 1654: 1648: 1623: 1619: 1613: 1578: 1574: 1564: 1545: 1541: 1531: 1520:. 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Index


ST segment
T waves
U waves
PR interval
Specialty
Critical care medicine
Symptoms
Feeling tired
leg cramps
constipation
abnormal heart rhythm
Complications
Cardiac arrest
Diarrhea
furosemide
steroids
dialysis
diabetes insipidus
hyperaldosteronism
hypomagnesemia
Diagnostic method
potassium
blood serum
feeling tired
leg cramps
weakness
constipation
abnormal heart rhythm
too slow

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