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28:. For example, in a human disease network, two diseases are linked if they share at least one associated gene. A typical human disease network usually derives from bipartite networks which consist of both diseases and genes information. Additionally, some human disease networks use other features such as
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database and termed human disease network. In 2009, Barrenas et al. derived complex disease-gene network using GWAs (Genome Wide
Association studies). In the same year, Hidalgo et al. published a novel way of building human phenotypic disease networks in which diseases were connected according to
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A large-scale human disease network shows scale-free property. The degree distribution follows a power law suggesting that only a few diseases connect to a large number of diseases, whereas most diseases have few links to others. Such network also shows a clustering tendency by disease classes.
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their calculated distance. In 2011, Cusick et al. summarized studies on genotype-phenotype associations in cellular context. In 2014, Zhou, et al. built a symptom-based human disease network by mining biomedical literature database.
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Kannan, Venkateshan et al. "Conditional
Disease Development extracted from Longitudinal Health Care Cohort Data using Layered Network Construction". Scientific Reports 6, 26170 (2016)
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In a symptom-based disease network, disease are also clustered according to their categories. Moreover, diseases sharing the same symptom are more likely to share the same genes and
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Barrenas, Fredrik, et al. "Network properties of complex human disease genes identified through genome-wide association studies." PLoS ONE 4.11 (2009): e8090.
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with reference to their genetic origins or other features. More specifically, it is the map of human disease associations referring mostly to disease
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Hidalgo, CĂ©sar A., et al. "A dynamic network approach for the study of human phenotypes." PLoS Computational
Biology 5.4 (2009): e1000353.
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Vidal, Marc, Michael E. Cusick, and Albert-Laszlo
Barabasi. "Interactome networks and human disease." Cell 144.6 (2011): 986-998.
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Goh, Kwang-Il, et al. "The human disease network." Proceedings of the
National Academy of Sciences 104.21 (2007): 8685-8690.
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http://www.barabasilab.com/pubs/CCNR-ALB_Publications/200705-14_PNAS-HumanDisease/200705-14_PNAS-HumanDisease-poster.pdf
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Zhou, XueZhong, et al. "Human symptoms–disease network." Nature
Communications 5 (2014).
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plot . Nodes are diseases. Two diseases are connected if they share a genetic component.
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