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Hodgkin lymphoma

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rates were higher in developed regions, with the greatest rates in the Americas (1.5 per 100,000), East Mediterranean Region (1.5 per 100,000), and Europe (2.0 per 100,000). The East Mediterranean Region also has the highest age-standardized mortality rate of 1.0 per 100,000, which is mainly attributed to lifestyle and environmental risk factors associated with transitional economies such as smoking, obesity, physical inactivity, and reproductive behaviors, as well as availability of diagnostic practices and awareness of the disease.
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study, after two cycles of ABVD chemotherapy, 83% of people were free of disease at 3 years if they had a negative PET versus only 28% in those with positive PET scans. This prognostic method improves on FFP estimates based on the seven conventional factors. Several trials are underway to see if PET-based risk adapted response can be used to improve a person's outcomes by changing chemotherapy early in people who are not responding.
1043:(also known as Matulane). The treatment is usually administered in four week cycles, often for six cycles. MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. MOPP was the first combination chemotherapy brought in that achieved a high success rate. It was developed at the National Cancer Institute in the 1960s by a team that included Vincent DeVita Jr. 1231:(which is a monoclonal antibody against CD20) is not routinely used to treat Hodgkin lymphoma due to the lack of CD20 surface antigens in most cases. The use of rituximab in Hodgkin lymphoma, including the lymphocyte predominant subtype has been recently reviewed. The evidence is very uncertain about the effect of Nivolumab for patients with a Hodgkin's lymphoma e.g. on the overall survival. 1246:(sometimes shortened to EBRT or XRT). Radiation oncologists deliver external beam radiation therapy to the lymphoma from a machine called a linear accelerator which produces high energy X-rays and electrons. People usually describe treatments as painless and similar to getting an X-ray. Treatments last less than 30 minutes each. 1596:
independently reported on a series of patients with the same disease that Hodgkin had previously described. Wilks, a successor to Hodgkin at Guy's Hospital, was unaware of Hodgkin's prior work on the subject. Bright informed Wilks of Hodgkin's contribution and in 1865, Wilks published a second paper,
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within the radiation therapy field. Most people with early-stage disease are now treated with abbreviated chemotherapy and involved site radiation therapy rather than with radiation therapy alone. Clinical research strategies are exploring reduction of the duration of chemotherapy and dose and volume
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Increased age is an adverse risk factor for Hodgkin lymphoma, but in general elderly people (≥ 60 years of age) without major comorbidities are sufficiently fit to tolerate therapy with curative intent. Despite this, treatment outcome in the elderly patient is not comparable to that of younger people
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regimen is typically only half as long as the ABVD but involves a more intensive chemotherapy schedule and incorporates radiation therapy. In a randomised controlled study in Italy, Stanford V was inferior to ABVD; however, this study has been heavily criticized due to its incorrect administration of
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Fermé C, Eghbali H, Meerwaldt JH, Rieux C, Bosq J, Berger F, Girinsky T, Brice P, van't Veer MB, Walewski JA, Lederlin P, Tirelli U, Carde P, Van den Neste E, Gyan E, Monconduit M, Diviné M, Raemaekers JM, Salles G, Noordijk EM, Creemers GJ, Gabarre J, Hagenbeek A, Reman O, Blanc M, Thomas J, Vié B,
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In 2016, there were 8,389 new cases and 1,000 mortalities attributed to Hodgkin lymphoma, a decrease from the 8,625 new cases and 1,120 mortalities in 2015. As of January 1, 2016, the 5-year limited duration prevalence of Hodgkin lymphoma was 37,513 representing 0.71% of all diagnosed cancers in the
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Recently, two novel targeted drugs have been developed for relapsing and refractory HL patients; Brentuximab vedotin, a CD30 antibody conjugated with a cytotoxic component MMAE, and the checkpoint inhibitors, Nivolumab and Pembrolizumab. This has been an important step in the treatment for the few,
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is a form of treatment for stages > II mainly used in Europe. The cure rate with the BEACOPP esc. regimen is approximately 10–15% higher than with standard ABVD in advanced stages. This was shown in a paper in The New England Journal of Medicine (Diehl et al.), but US physicians still favor ABVD,
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Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, Carter A, Casey DC, Charlson FJ, Chen AZ, Coggeshall M, Cornaby L, Dandona L, Dicker DJ, Dilegge T, Erskine HE, Ferrari AJ, Fitzmaurice C, Fleming T, Forouzanfar MH, Fullman N, Gething PW, Goldberg EM, Graetz N, Haagsma JA, Hay SI, Johnson CO,
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Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, Casey DC, Charlson FJ, Chen AZ, Coates MM, Coggeshall M, Dandona L, Dicker DJ, Erskine HE, Ferrari AJ, Fitzmaurice C, Foreman K, Forouzanfar MH, Fraser MS, Fullman N, Gething PW, Goldberg EM, Graetz N, Haagsma JA, Hay SI, Huynh C, Johnson
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For lymphomas, there are a few different ways radiation oncologists target the cancer cells. Involved site radiation is when the radiation oncologists give radiation only to those parts of the person's body known to have the cancer. Very often, this is combined with chemotherapy. Radiation therapy
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In 2010, globally it resulted in about 18,000 deaths down from 19,000 in 1990. In 2012, there were an estimated 65,950 cases and 25,469 deaths from Hodgkin lymphoma worldwide, with 28,852 and 37,098 cases occurring in developed and developing countries, respectively. However, the age-standardized
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More recently, the use of positron emission tomography (PET) early after commencing chemotherapy has demonstrated to have powerful prognostic ability. This enables assessment of an individual's response to chemotherapy as the PET activity switches off rapidly in people who are responding. In this
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The evidence is very uncertain about the effect of negative (= good prognosis) or positive (= bad prognosis) interim PET scan results for patients with a Hodgkin's lymphoma on the progression-free survival. Negative interim PET scan results may result in an increase in progression-free survival
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In 1998, an international effort identified seven prognostic factors that accurately predict the success rate of conventional treatment in people with locally extensive or advanced-stage Hodgkin lymphoma. Freedom from progression (FFP) at five years was directly related to the number of factors
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Adding physical exercises to the standard treatment for adult patients with haematological malignancies like Hodgkin lymphoma may result in little to no difference in the mortality, the quality of life and the physical functioning. These exercises may result in a slight reduction in depression.
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The absence of systemic symptoms is signified by adding "A" to the stage; the presence of systemic symptoms is signified by adding "B" to the stage. For localised extranodal extension from mass of nodes that does not advance the stage, subscript "E" is added. Splenic involvement is signified by
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curve for the number of cases; that is, it occurs most frequently in two separate age groups, the first being young adulthood (age 15–35) and the second being in those over 55 years old although these peaks may vary slightly with nationality. Overall, it is more common in males, except for the
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specimen (the cell composition around the Reed–Sternberg cell(s)). Presence of EBV in Reed-Sternberg cells is most commonly found in the subtypes lymphocyte depleted HL (>70%) and mixed cellularity HL (70%), whilst being less prevalent in lymphocyte-rich HL (40%) and relatively uncommon by
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The two main types of Hodgkin lymphoma are classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. The prevalence of classic Hodgkin lymphoma and nodular-lymphocyte Hodgkin lymphoma are about 90 and 10%, respectively. The morphology, phenotype, molecular features, and,
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Estcourt L, Stanworth S, Doree C, Hopewell S, Murphy MF, Tinmouth A, Heddle N, et al. (Cochrane Haematological Malignancies Group) (May 2012). "Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell
922:(RSC) (typical and variants) admixed within a reactive cell infiltrate composed of variable proportions of lymphocytes, histiocytes, eosinophils, and plasma cells. The Reed–Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an unusual 4351:
Specht L, Yahalom J, Illidge T, Berthelsen AK, Constine LS, Eich HT, Girinsky T, Hoppe RT, Mauch P, Mikhaeel NG, Ng A (July 2014). "Modern radiation therapy for Hodgkin lymphoma: field and dose guidelines from the international lymphoma radiation oncology group (ILROG)".
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Other studies have reported the following to be the most important adverse prognostic factors: mixed-cellularity or lymphocyte-depleted histologies, male sex, large number of involved nodal sites, advanced stage, age of 40 years or more, the presence of B symptoms, high
1731:, Canadian child actor, was diagnosed in 1994 at age 9. Treatments that rendered him cancer-free, including chemotherapy, a bone marrow transplant, and radiation, left him with permanent lung and respiratory problems and he died in 2001 just after turning 16. 405:
sign of Hodgkin lymphoma. The pain typically has an onset within minutes after ingesting alcohol, and is usually felt as coming from the vicinity where there is an involved lymph node. The pain has been described as either sharp and stabbing or dull and
278:. The choice of treatment often depends on how advanced the cancer has become and whether or not it has favorable features. If the disease is detected early, a cure is often possible. In the United States, 88% of people diagnosed with Hodgkin lymphoma 937:
Characteristics of classic Reed–Sternberg cells include large size (20–50 micrometres), abundant, amphophilic, finely granular/homogeneous cytoplasm; two mirror-image nuclei (owl eyes) each with an eosinophilic nucleolus and a thick nuclear membrane
6027: 1254:. Radiation to below the diaphragm to the abdomen, spleen or pelvis is called inverted-Y field radiation. Total nodal irradiation is when the therapist gives radiation to all the lymph nodes in the body to destroy cells that may have spread. 4536:"Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation" 3583:
Wienand K, Chapuy B, Stewart C, Dunford AJ, Wu D, Kim J, Kamburov A, Wood TR, Cader FZ, Ducar MD, Thorner AR, Nag A, Heubeck AT, Buonopane MJ, Redd RA, Bojarczuk K, Lawton LN, Armand P, Rodig SJ, Fromm JR, Getz G, Shipp MA (December 2019).
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Treatment of Hodgkin's disease has been improving over the past few decades. Recent trials that have made use of new types of chemotherapy have indicated higher survival rates than have previously been seen. In a 2007 European trial, the
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In 2015, about 574,000 people globally had Hodgkin lymphoma, and 23,900 (4.2%) died. In the United States, 0.2% of people are affected at some point in their life. Most people are diagnosed with the disease between the ages of 20 and 40.
773:(which involves opening the abdominal cavity and visually inspecting for tumors) were performed. Lymphangiograms or laparotomies are very rarely performed, having been supplanted by improvements in imaging with the CT scan and PET scan. 6295: 392:
Pain following alcohol consumption: Classically, involved nodes are painful after alcohol consumption, though this phenomenon is very uncommon, occurring in only two to three percent of people with Hodgkin lymphoma, thus having a low
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maybe because some physicians think that BEACOPP induces more secondary leukemia. However, this seems negligible compared to the higher cure rates. BEACOPP is more expensive because of the requirement for concurrent treatment with
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Is a common subtype and is composed of numerous classic RS cells admixed with numerous inflammatory cells including lymphocytes, histiocytes, eosinophils, and plasma cells without sclerosis. This type is most often associated with
3849:"ABVD versus modified stanford V versus MOPPEBVCAD with optional and limited radiotherapy in intermediate- and advanced-stage Hodgkin's lymphoma: final results of a multicenter randomized trial by the Intergruppo Italiano Linfomi" 869:
Affected lymph nodes (most often, laterocervical lymph nodes) are enlarged, but their shape is preserved because the capsule is not invaded. Usually, the cut surface is white-grey and uniform; in some histological subtypes (e.g.
1974:, Portuguese professional footballer, diagnosed in 2017 Tengarrinha died on October 30, 2021, at the age of 32. Hours later, his former teams FC Porto and Boavista FC paid tribute to him before the local derby. playing for 570: 1520:
Hodgkin lymphoma accounts for 0.6% of all male cancer cases, and 0.4% of all female cancer cases in Canada. In 2017, approximately 990 Canadians will be diagnosed with Hodgkin lymphoma, and 140 will die of the disease.
705:(IL-21), which was once thought to be exclusive to T-cells. This feature may explain the behavior of classic Hodgkin lymphoma, including clusters of other immune cells gathered around HL cells (infiltrate) in cultures. 1496:
variant, which is slightly more common in females. The annual number of cases of Hodgkin lymphoma is 2.7 per 100,000 per persons per year, and the disease accounts for slightly less than 1% of all cancers worldwide.
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The high cure rates and long survival of many people with Hodgkin lymphoma has led to a high concern with late adverse effects of treatment, including cardiovascular disease and second malignancies such as acute
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present in a person. The five-year FFP for people with zero factors is 84%. Each additional factor lowers the five-year FFP rate by 7%, such that the five-year FFP for a person with five or more factors is 42%.
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of radiation therapy in an attempt to reduce late morbidity and mortality of treatment while maintaining high cure rates. Hospitals are also treating those who respond quickly to chemotherapy with no radiation.
412:: Nonspecific back pain (pain that cannot be localised or its cause determined by examination or scanning techniques) has been reported in some cases of Hodgkin lymphoma. The lower back is most often affected. 453:(PET) is used to detect small deposits that do not show on CT scanning. PET scans are also useful in functional imaging (by using a radiolabeled glucose to image tissues of high metabolism). In some cases, a 3697:
Aldin A, Umlauff L, Estcourt LJ, Collins G, Moons KG, Engert A, Kobe C, von Tresckow B, Haque M, Foroutan F, Kreuzberger N, Trivella M, Skoetz N, et al. (Cochrane Haematology Group) (January 2020).
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or chemotherapy. The choice of treatment depends on the age, sex, bulk and the histological subtype of the disease. Adding localised radiation therapy after the chemotherapy regimen may provide a longer
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It is possible that patients undergoing a chemotherapy need a platelet transfusion. If a stem cell transplantation is necessary for the treatment of a relapse, graft-versus-host diseases might occur.
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compared if the adjusted result was measured. Negative interim PET scan results probably result in a large increase in the overall survival compared to those with a positive interim PET scan result,
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Gobbi PG, Levis A, Chisesi T, Broglia C, Vitolo U, Stelitano C, Pavone V, Cavanna L, Santini G, Merli F, Liberati M, Baldini L, Deliliers GL, Angelucci E, Bordonaro R, Federico M (December 2005).
2251:"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015" 1045:
Although no longer the most effective combination, MOPP is still used after relapse or where the person has certain allergies or lung or heart problems which prevents the use of another regimen.
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The current approach for treatment aims to reduce the acute and long-term toxicities associated with Hodgkin lymphoma (e.g. cardiac damage and secondary cancers) and increase overall survival.
1589:. Hodgkin's paper went largely unnoticed, however, even though Bright highlighted it in an 1838 publication. Indeed, Hodgkin himself did not view his contribution as particularly significant. 7530: 6303: 4585:"Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition" 2910:
Lennon AM, Buchanan AH, Kinde I, Warren A, Honushefsky A, Cohain AT, Ledbetter DH, Sanfilippo F, Sheridan K, Rosica D, Adonizio CS, Hwang HJ, Lahouel K, Cohen JD, Douville C (2020-07-03).
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Lacunar RSC is large, with a single hyperlobulated nucleus, multiple, small nucleoli and eosinophilic cytoplasm which is retracted around the nucleus, creating an empty space ("lacunae").
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Hodgkin lymphoma must be distinguished from noncancerous causes of lymph node swelling (such as various infections) and from other types of cancer. Definitive diagnosis is by lymph node
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Hodgkin lymphoma accounts for less than 1% of all cancer cases and deaths in the UK. Around 1,800 people were diagnosed with the disease in 2011, and around 330 people died in 2012.
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to increase production of white blood cells. Currently, the German Hodgkin Study Group tests 8 cycles (8x) BEACOPP esc vs. 6x BEACOPP esc vs. 8x BEACOPP-14 baseline (HD15-trial).
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and may be confused with the early, so-called 'cellular' phase of the nodular sclerosing subtype. This type of Hodgkin lymphoma is most commonly seen in immunocompromised people.
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Grewal R, Irimie A, Naidoo N, Mohamed N, Petrushev B, Chetty M, Tomuleasa C, Abayomi EA (March 2018). "Hodgkin's lymphoma and its association with EBV and HIV infection".
741:: that is, they will undergo a series of tests and procedures that will determine what areas of the body are affected. These procedures may include documentation of their 3962:
Saini KS, Azim HA, Cocorocchio E, Vanazzi A, Saini ML, Raviele PR, Pruneri G, Peccatori FA (August 2011). "Rituximab in Hodgkin lymphoma: is the target always a hit?".
2839:"Occurrence of minimal change nephrotic syndrome in classic Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes" 259:. Diagnosis is conducted by confirming the presence of cancer and identifying RS cells in lymph node biopsies. The virus-positive cases are classified as a form of the 686:) are not expressed on all cells, Reed–Sternberg cells are usually of B cell origin. Although Hodgkin's is now frequently grouped with other B-cell malignancies, some 6828: 5622: 674:
CT image of a 46-year-old person with Hodgkin lymphoma, image at neck height. On the left side of the person's neck enlarged lymph nodes are visible (marked in red).
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Microscopic examination of the lymph node biopsy reveals complete or partial effacement of the lymph node architecture by scattered large malignant cells known as
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Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J, et al. (Cochrane Haematological Malignancies Group) (January 2019).
2022:"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010" 1295:
Furthermore, aerobic physical exercises probably reduce fatigue. The evidence is very uncertain about the effect on anxiety and serious adverse events. 
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is often present in people with Hodgkin lymphoma. The enlargement is seldom massive, and the size of the spleen may fluctuate during the course of treatment.
4825:"Chemotherapy alone or combined chemotherapy and involved field radiotherapy in favorable risk early-stage classical Hodgkin lymphoma-a 10 years experience" 1707:, a teenager whose refusal to undergo further conventional treatment after relapsing in 2006 resulted in a court battle and a change to Virginia laws about 5500: 6128: 716:(NLPHL) is another subtype of Hodgkin lymphoma distinct from classic Hodgkin lymphoma and is characterized by the presence of popcorn cells which express 7535: 2777:
Hodgon DC, Gospodarowicz MK (2007). "Clinical Evaluation and Staging of Hodgkin Lymphoma". In Hoppe RT, Mauch PT, Armitage JO, Diehl V, Weiss LM (eds.).
3345:"Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha" 7344: 6001: 5557: 2120: 1603:
and WS Greenfield first described the microscopic characteristics of Hodgkin lymphoma in 1872 and 1878, respectively. In 1898 and 1902, respectively,
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entitled "Cases of enlargement of the lymphatic glands and spleen", in which he named the illness "Hodgkin's disease" in honor of his predecessor.
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combines a biography of the American radiation oncologist (1918–84) with a history of the lymphatic cancer whose treatment he helped to transform.
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Estcourt LJ, Stanworth SJ, Doree C, Hopewell S, Trivella M, Murphy MF, et al. (Cochrane Haematological Malignancies Group) (November 2015).
908: 713: 475: 248: 3039: 1074:. Developed in Italy in the 1970s, the ABVD treatment typically takes between six and eight months, although longer treatments may be required. 617:
Is a rare subtype, composed of large numbers of often pleomorphic RS cells with only few reactive lymphocytes which may easily be confused with
317:) are most frequently involved (80–90% of the time, on average). The lymph nodes of the chest are often affected, and these may be noticed on a 282:. For those under the age of 20, rates of survival are 97%. Radiation and some chemotherapy drugs, however, increase the risk of other cancers, 7300: 5873: 6639: 5920: 765:
for staging. On the PET scan, sites involved with lymphoma light up very brightly enabling accurate and reproducible imaging. In the past, a
4774:"Decreased Prognostic Value of International Prognostic Score in Chinese Advanced Hodgkin Lymphoma Patients Treated in the Contemporary Era" 6990: 6102: 5582: 4632:
Knips L, Bergenthal N, Streckmann F, Monsef I, Elter T, Skoetz N, et al. (Cochrane Haematological Malignancies Group) (January 2019).
5124: 900: 7503: 5480: 2715: 2368: 1803:. In 2010, aged 38, Hall announced he was undergoing treatment for Hodgkin lymphoma; within two years, the disease was in full remission. 848: 836: 824: 6203: 5345: 812: 7542: 7088: 6967: 6833: 6452: 6434: 5430: 5214:
Hellman S (2007). "Brief Consideration of Thomas Hodgkin and His Times". In Hoppe RT, Mauch PT, Armitage JO, Diehl V, Weiss LM (eds.).
3700:"Interim PET-results for prognosis in adults with Hodgkin lymphoma: a systematic review and meta-analysis of prognostic factor studies" 1660: 5899: 5836: 5815: 4875:
Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M, Meignan M, Malkowski B, Hofman MS, Barrington SF (May 2013).
4102: 1777:, announced that he was diagnosed with Hodgkin lymphoma in a video he released on 19 May 2023. Green would announce his entrance into 7614: 6269: 3796:
Perri F, Della Vittoria Scarpati G, Buonerba C, Di Lorenzo G, Longo F, Muto P, Schiavone C, Sandomenico F, Caponigro F (2013-05-10).
1753:. Diagnosed in June 2014 at the age of 23. Continued to play until becoming too ill due to chemotherapy. Made recovery in early 2015. 1750: 1582: 6061: 1653:, co-founder of Microsoft was diagnosed with Hodgkin lymphoma in 1982. He later died from non-Hodgkin lymphoma, on October 15, 2018. 1614:
Tissue specimens from Hodgkin's seven cases were preserved at Guy's Hospital. Nearly 100 years after Hodgkin's initial publication,
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Hodgkin's report on the seven cases, entitled "On some morbid appearances of the absorbent glands and spleen", was presented to the
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Hodgkin lymphoma can be sub-classified by histological type. The cell histology in Hodgkin lymphoma is not as important as it is in
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Edwards-Bennett SM, Jacks LM, Moskowitz CH, Wu EJ, Zhang Z, Noy A, Portlock CS, Straus DJ, Zelenetz AD, Yahalom J (March 2010).
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Lamprecht B, Kreher S, Anagnostopoulos I, Jöhrens K, Monteleone G, Jundt F, Stein H, Janz M, Dörken B, Mathas S (October 2008).
2886: 1578:. Carswell's report of the seventh case was accompanied by numerous illustrations that aided early descriptions of the disease. 1275:
In childhood cases of Hodgkin lymphoma, long-term endocrine adverse effects are a major concern, mainly gonadal dysfunction and
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alone. People of any stage with a large mass in the chest are usually treated with combined chemotherapy and radiation therapy.
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is distributed close to the nuclear membrane). Almost all of these cells have an increased copy number of chromosome 9p/9p24.1.
7339: 3898:"Stanford V program for locally extensive and advanced Hodgkin lymphoma: the Memorial Sloan-Kettering Cancer Center experience" 2643: 1611:
independently described the cytogenetic features of the malignant cells of Hodgkin lymphoma, now called Reed–Sternberg cells.
7158: 6709: 6392: 5474: 5440: 5223: 4991: 4967: 3014: 2786: 2733: 2362: 2223: 969:: the treatment and prognosis in classic Hodgkin lymphoma usually depends on the stage of disease rather than the histotype. 5618: 1566:, London, Hodgkin studied seven people with painless lymph node enlargement. Of the seven cases, two were under the care of 720:. Due to these differences, among others, NLPHL is often treated differently from classic Hodgkin lymphoma, including using 7604: 7487: 5407: 4733:"A prognostic score for advanced Hodgkin's disease. International Prognostic Factors Project on Advanced Hodgkin's Disease" 1508:
infection. In contrast to many other lymphomas associated with HIV infection it occurs most commonly in people with higher
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May present with airway obstruction, pleural/pericardial effusion, hepatocellular dysfunction, or bone-marrow infiltration.
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Rezk SA, Zhao X, Weiss LM (September 2018). "Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update".
1962:, United States Senator from Pennsylvania (1981–2011), diagnosed in 2005. He later died from non-Hodgkin lymphoma in 2012. 7443: 7063: 6861: 6745: 2837:
Audard V, Zhang SY, Copie-Bergman C, Rucker-Martin C, Ory V, Candelier M, Baia M, Lang P, Pawlak A, Sahali D (May 2010).
2155: 1996:, American professional wrestler, reported to be ill with diagnosis from June 2022, completed treatment February 17, 2023 1887: 949:
Hodgkin cell (atypical mononuclear RSC) is a variant of RS cell, which has the same characteristics but is mononucleated.
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Stage I is involvement of a single lymph node region (I) (mostly the cervical region) or single extralymphatic site (Ie);
7391: 7102: 6325: 4391: 2176: 255:(EBV) and these are generally the classic form. Other risk factors include a family history of the condition and having 7334: 5715: 4924: 1308:
for those people with a favorable prognosis (FFP) was 98%, while that for people with worse outlooks was at least 85%.
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Is a rare subtype, show many features which may cause diagnostic confusion with nodular lymphocyte predominant B-cell
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Systemic symptoms: About one-third of people with Hodgkin disease may also present with systemic symptoms, including:
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Kluin-Nelemans JC, Viseu F, Baars JW, Poortmans P, Lugtenburg PJ, Carrie C, Jaubert J, Henry-Amar M (November 2007).
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and the disease is a different entity in older people where different considerations enter into treatment decisions.
934:+/− immunophenotype. In approximately 50% of cases, the Reed–Sternberg cells are infected by the Epstein–Barr virus. 761:(MRI) scans of the chest, abdomen and pelvis, and usually a bone marrow biopsy. PET scan is now used instead of the 7295: 4959: 1838: 1714: 777: 5145: 3997:
Ekstrand BC, Lucas JB, Horwitz SM, Fan Z, Breslin S, Hoppe RT, Natkunam Y, Bartlett NL, Horning SJ (2003-06-01).
1949: 1243: 5531: 3586:"Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion" 1956:, announced in August 2015 that he was diagnosed with Hodgkin's disease. He died of the disease in October 2015. 7525: 7517: 7376: 7254: 7193: 7179: 7073: 7014: 6851: 6777: 6124: 1357: 622: 1618:
reexamination confirmed Hodgkin lymphoma in only three of seven of these people. The remaining cases included
1279:. Gonadal dysfunction seems to be the most severe endocrine long-term effect, especially after treatment with 7573: 7483: 7433: 7329: 7058: 6842: 4772:
Wang Q, Qin Y, Kang SY, He XH, Liu P, Yang S, Zhou SY, Zhang CG, Gui L, Yang JL, Sun Y, Shi YK (2016-12-05).
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van Dorp W, van Beek RD, Laven JS, Pieters R, de Muinck Keizer-Schrama SM, van den Heuvel-Eibrink MM (2011).
1608: 1575: 6005: 5561: 3186: 2112: 7465: 7371: 7354: 7162: 6716: 6625: 754: 698:) are occasionally expressed. However, this may be an artifact of the ambiguity inherent in the diagnosis. 450: 5978: 2959:
McKay P, Fielding P, Gallop-Evans E, Hall GW, Lambert J, Leach M, Marafioti T, McNamara C (January 2016).
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by more than one third, or the presence of a nodal mass measuring more than 10 cm in any dimension.)
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compared with chemotherapy treatment alone. People with later disease (III, IVA, or IVB) are treated with
958:"Popcorn" RSC (lympho-histiocytic variant) is a small cell, with a very lobulated nucleus, small nucleoli. 7406: 7279: 6985: 5687: 618: 394: 314: 220:(RS cells) are present in the patient's lymph nodes. The condition was named after the English physician 3475: 7321: 3749:"Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early stage Hodgkin lymphoma" 1820:
Daniel Hauser, whose mother fled with him in 2009 in order to prevent him from undergoing chemotherapy.
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On the basis of this staging, the person will be classified according to a staging classification (the
758: 309:. The nodes may also feel rubbery and swollen when examined. The nodes of the neck, armpits and groin ( 5324: 3009:(Revised 4th ed.). Lyon: International Agency for Research on Cancer, World Health Organization. 7599: 7209: 7050: 6972: 6456: 6384: 5865: 5218:(2nd ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. pp. 3–6. 3294:
Tzankov A, Bourgau C, Kaiser A, Zimpfer A, Maurer R, Pileri SA, Went P, Dirnhofer S (December 2005).
1921: 1674: 1058:
is the standard treatment of Hodgkin's disease in the US. The abbreviation stands for the four drugs
986: 794:
Stage III is involvement of lymph node regions on both sides of the diaphragm, which may include the
724:
in combination with AVBD chemotherapy, though individual cases vary and clinical trials are ongoing.
2961:"Guidelines for the investigation and management of nodular lymphocyte predominant Hodgkin lymphoma" 1999:
Rick Czaplewski, Author Better Dirty Than Done, Motivational Speaker, 2009 Boston Marathon Finisher.
7411: 7239: 6532: 4167:"Hodgkin lymphoma: 2014 update on diagnosis, risk-stratification, and management: Hodgkin lymphoma" 1668: 1638: 1484: 990: 6877: 6447: 4263:
Eichenauer D, Engert A, André M, Federico M, Illidge T, Hutchings M, Ladetto M (September 2014).
3937: 3088: 1305: 919: 279: 217: 156: 5663: 5586: 1842:. After three months of chemotherapy and one month of radiation, the cancer went into remission. 419:, or more simply "P-E fever". However, there is debate as to whether the P-E fever truly exists. 7428: 7305: 7284: 7198: 6979: 2912:"Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention" 1953: 1546: 1348: 487: 426: 252: 106: 6583: 6488: 5464: 4265:"Hodgkin's lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up" 2712: 2352: 1759:, Australian singer, songwriter, and actress. She was diagnosed in July 2003 at the age of 18. 7609: 7437: 7027: 7000: 6921: 6823: 6228: 889: 878: 416: 361:; thus, presence of these indicate that the person's stage is, for example, 2B instead of 2A. 6617: 3668: 1746: 1558:, although Hodgkin noted that perhaps an earlier reference to the condition was provided by 658: 7234: 6846: 6757: 6665: 5844: 5807: 5720: 4082: 1985: 1971: 1778: 1619: 1488: 1480: 1055: 966: 596: 483: 479: 310: 5385: 2020:
Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. (December 2012).
8: 7034: 6818: 6788: 6513: 1925: 1849: 1784: 1704: 999: 788: 750: 332: 4046:
Borchmann S, Engert A, Böll B (September 2018). "Hodgkin lymphoma in elderly patients".
2064: 621:. Many cases previously classified within this category would now be reclassified under 7498: 6066: 5301: 5284: 5093: 5068: 5044: 5019: 4906: 4849: 4824: 4800: 4773: 4713: 4658: 4633: 4609: 4584: 4560: 4535: 4438: 4413: 4240: 4196: 4147: 4028: 3878: 3824: 3797: 3773: 3748: 3724: 3699: 3610: 3585: 3560: 3543: 3456: 3325: 3165: 3116: 3069: 3040:"From Hodgkin disease to Hodgkin lymphoma: biologic insights and therapeutic potential" 2936: 2911: 2863: 2838: 2683: 2666: 2512: 2469: 2328: 2303: 2275: 2250: 2077: 1799: 1664: 1276: 650: 633: 607: 581: 558: 422: 386: 351: 77: 6443: 5252: 5067:
Biggar RJ, Jaffe ES, Goedert JJ, Chaturvedi A, Pfeiffer R, Engels EA (December 2006).
4463:"Long-term endocrine side effects of childhood Hodgkin's lymphoma treatment: a review" 4134: 4117: 2752: 2319: 2266: 2037: 1893: 415:
Cyclical fever: People may also present with a cyclical high-grade fever known as the
7578: 7229: 7218: 7008: 6898: 6813: 6543: 6398: 6388: 5789: 5470: 5436: 5306: 5256: 5219: 5098: 5049: 4963: 4898: 4854: 4805: 4754: 4705: 4663: 4614: 4565: 4516: 4484: 4443: 4369: 4333: 4294: 4245: 4188: 4139: 4094: 4063: 4020: 3979: 3919: 3870: 3829: 3778: 3729: 3642: 3615: 3601: 3565: 3502: 3448: 3407: 3366: 3317: 3276: 3235: 3157: 3152: 3135: 3108: 3104: 3061: 3020: 3010: 2982: 2941: 2868: 2819: 2782: 2729: 2688: 2603: 2553: 2504: 2461: 2404: 2358: 2333: 2280: 2151: 2069: 2051: 2046: 1965: 1833: 1722: 1634: 1563: 1559: 1493: 981: 871: 522: 271: 136: 122: 117: 61: 7248: 6605: 6518: 6252:"Brandon Tartikoff, Former NBC Executive Who Transformed TV in the 80's, Dies at 48" 5808:"Cancer-Free Michael C. Hall Back to Work on Dexter—Health, Dexter, Michael C. Hall" 4717: 4200: 4151: 4032: 3882: 3460: 3329: 3120: 2635: 2516: 2473: 7348: 7127: 6594: 5606: 5505: 5296: 5248: 5088: 5080: 5039: 5031: 4983: 4910: 4888: 4844: 4836: 4795: 4785: 4744: 4695: 4653: 4649: 4645: 4604: 4600: 4596: 4555: 4551: 4547: 4512: 4508: 4474: 4433: 4425: 4361: 4325: 4284: 4276: 4235: 4227: 4178: 4129: 4055: 4010: 3971: 3909: 3860: 3819: 3809: 3768: 3764: 3760: 3719: 3715: 3711: 3605: 3597: 3555: 3438: 3397: 3356: 3307: 3266: 3225: 3169: 3147: 3100: 3073: 3051: 2972: 2931: 2923: 2858: 2850: 2811: 2678: 2593: 2543: 2496: 2453: 2425:
Hodgkin T (1832). "On some morbid experiences of the absorbent glands and spleen".
2396: 2323: 2315: 2270: 2262: 2215: 2081: 2059: 2041: 2033: 1993: 1929: 1911: 1810: 1728: 1600: 1392: 1331: 1280: 1183: 449:
are also performed to assess function of major organs and safety for chemotherapy.
318: 209: 5517: 4414:"Strategies for optimizing the response of cancer and normal tissues to radiation" 3253:
Bräuninger A, Schmitz R, Bechtel D, Renné C, Hansmann ML, Küppers R (April 2006).
2500: 2457: 1858:(1917–1950), Romanian classical pianist and composer. Diagnosed in 1947, received 787:
Stage II is involvement of two or more lymph node regions on the same side of the
41: 7121: 7116: 6925: 6809: 6675: 6670: 6537: 6423: 6150: 5084: 4365: 4059: 3999:"Rituximab in lymphocyte-predominant Hodgkin disease: results of a phase 2 trial" 3427:"Observer variation in interpreting 18F-FDG PET/CT findings for lymphoma staging" 3402: 3385: 3361: 3344: 2854: 2719: 2598: 2581: 1790: 1708: 1678: 1023: 389:: The enlargement of both the liver and spleen can be caused by the same disease. 302: 237: 94: 5943: 5941: 5178: 4749: 4732: 2815: 305:: The most common symptom of Hodgkin is the painless enlargement of one or more 7568: 6177:"Chip Roy's plan to get Washington out of the way includes going there himself" 6048: 5509: 4634:"Aerobic physical exercise for adult patients with haematological malignancies" 4015: 3998: 3975: 3634: 3494: 3255:"Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma" 3056: 1915: 1871: 1806: 1734: 1615: 1604: 1571: 1555: 1384: 806:
adding "S" to the stage. The inclusion of "bulky disease" is signified by "X".
766: 737: 702: 221: 185: 6548: 6270:"Portuguese midfielder Bernardo Tengarrinha diagnosed with linfoma de Hodgkin" 5764: 5736: 5495: 5239:
Dawson PJ (December 1999). "The original illustrations of Hodgkin's disease".
4893: 4876: 3795: 3747:
Blank O, von Tresckow B, Monsef I, Specht L, Engert A, Skoetz N (April 2017).
3526: 3443: 3426: 3312: 3295: 3230: 3213: 3024: 1633:
Hodgkin lymphoma was one of the first cancers to be treated successfully with
645: 628: 602: 576: 553: 425:
can occur in individuals with Hodgkin lymphoma and is most commonly caused by
7593: 7475: 7174: 7083: 7039: 6856: 6730: 6419: 6402: 5938: 5020:"Epidemiological Overview of Hodgkin Lymphoma across the Mediterranean Basin" 4790: 4684:"Chemotherapy plus involved-field radiation in early-stage Hodgkin's disease" 1959: 1941: 1907: 1903: 1883: 1877: 1865: 1845: 1794: 1756: 1694: 1684: 961:"Mummy" RSC has a compact nucleus with no nucleolus and basophilic cytoplasm. 402: 283: 144: 6503: 4840: 4479: 4462: 4280: 4083:"Hodgkin's lymphoma in the elderly: a different disease in patients over 60" 3914: 3897: 3865: 3848: 2927: 2055: 980:
People with early stage disease (IA or IIA) can be treated effectively with
791:(II) or of one lymph node region and a contiguous extralymphatic site (IIe); 466:
therefore, the clinical behaviour and presentation of the two types differ.
357:
Systemic symptoms such as fever, night sweats, and weight loss are known as
7078: 6740: 5260: 5102: 5053: 5035: 4902: 4858: 4809: 4709: 4667: 4618: 4569: 4520: 4488: 4447: 4373: 4337: 4298: 4264: 4249: 4192: 4143: 4098: 4067: 4024: 3983: 3923: 3874: 3833: 3798:"Combined chemo-radiotherapy in locally advanced nasopharyngeal carcinomas" 3782: 3733: 3646: 3619: 3569: 3506: 3452: 3411: 3370: 3321: 3280: 3239: 3161: 3112: 3065: 2986: 2945: 2872: 2607: 2557: 2508: 2465: 2408: 2337: 2284: 2073: 1855: 1766: 1740: 1718: 1623: 1593: 1268: 1187: 1178: 1168: 1098: 1040: 912: 762: 543: 534:
showing scattered lacunar classic RS cells set in a background of reactive
454: 376: 366: 267: 229: 132: 86: 5310: 4758: 3814: 2823: 2692: 2400: 1315:
The adverse prognostic factors identified in the international study are:
801:
Stage IV is disseminated involvement of one or more extralymphatic organs.
383:, due to liver involvement, is infrequent in people with Hodgkin lymphoma. 6752: 6578: 4700: 4683: 3473: 1823: 1793:(born February 1, 1971), American actor, best known for his lead role as 1698: 1585:
in January 1832 and was subsequently published in the society's journal,
1361: 1173: 1161: 1156: 1152: 1147: 1113: 1108: 1103: 1071: 1067: 539: 535: 338: 306: 247:
The two major types of Hodgkin lymphoma are classic Hodgkin lymphoma and
233: 101: 90: 53: 5636: 4313: 4289: 3425:
Hofman MS, Smeeton NC, Rankin SC, Nunan T, O'Doherty MJ (October 2009).
798:(IIIs) or limited contiguous extralymphatic organ or site (IIIe, IIIes); 6648: 6600: 5018:
Salati M, Cesaretti M, Macchia M, Mistiri ME, Federico M (2014-06-29).
4329: 2548: 2531: 1990:
reality television series. Zohn was diagnosed twice (in 2009 and 2011).
1981: 1945: 1897: 1762: 1656: 1650: 1325: 1250:
directed above the diaphragm to the neck, chest or underarms is called
1219: 1214: 1142: 1078: 1059: 1036: 1009: 904: 893: 770: 670: 589: 491: 446: 358: 213: 66: 49: 6471: 4215: 4183: 4166: 3271: 3254: 3212:
Küppers R, Schwering I, Bräuninger A, Rajewsky K, Hansmann ML (2002).
2977: 2960: 1914:, diagnosed in May 2008 while signed as a minor league player for the 6589: 6554: 5535: 5285:"Comments on the anniversary of the description of Hodgkin's disease" 4231: 3342: 2836: 2781:(2nd ed.). Lippincott Williams & Wilkins. pp. 123–132. 1968:, American television executive, diagnosed around 1974, died in 1997. 1859: 1829: 1774: 1677:, Welsh professional footballer, diagnosed in 2021 while playing for 1388: 1228: 1203: 1198: 1135: 1130: 1125: 1063: 1028: 939: 742: 721: 409: 341:
of at least 10% of the person's total body mass in six months or less
151: 4429: 3007:
WHO classification of tumours of haematopoietic and lymphoid tissues
2021: 1817:, died on October 25, 2002, after being diagnosed earlier that year. 1504:
The number of cases of Hodgkin lymphoma is increased in people with
732:
The staging is the same for both Hodgkin and non-Hodgkin lymphomas.
7563: 6652: 1975: 1935: 1627: 1264: 327: 256: 201: 110: 70: 5658: 3211: 1691:" (c)1936, Born 1888, Maryville, MO, died 1955, Forest Hills,NY. 907:
showing a "popcorn cell", the Reed–Sternberg cell variant seen in
6559: 5741: 3542:
Vockerodt M, Cader FZ, Shannon-Lowe C, Murray P (December 2014).
3476:"Table 4. Ann Arbor Staging Classification for Hodgkin Lymphomaa" 3296:"Rare expression of T-cell markers in classic Hodgkin's lymphoma" 3190: 1342: 1120: 1085: 1032: 1014: 6351: 6103:"Nikola Pokrivač: Nema predaje, sve ću podnijeti za ženu i kćer" 5921:"Comedian Sean Kent laughs off hecklers, cancer to stay on road" 5069:"Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS" 3541: 7111: 6498: 6483: 6438: 6089:"Denver health care activist speaking at Democratic convention" 5583:"Childhood Cancer Research Program—Michael Cuccione Foundation" 5534:. NBC News. Associated Press. September 5, 2006. Archived from 4631: 3895: 1852:
and founder of the Mario Lemieux Foundation, diagnosed in 1993.
1770: 1082:
radiotherapy, diverging from the original Stanford V protocol.
795: 687: 679: 663: 510: 494: 442: 370: 205: 180: 6204:"Minnesota Timberwolves Say Head Coach Flip Saunders Has Died" 5974: 5692: 4874: 4533: 4501: 4350: 298:
People with Hodgkin lymphoma may present with these symptoms:
6934: 6799: 6783: 6647: 5866:"Minnesota: Evaluation Ordered for a 13-Year-Old With Cancer" 5432:
Book: Words that Shaped our World, ref to Dale Carnagie+death
5017: 4823:
Ali S, Basit A, Kazmi AS, Sidhu A, Badar F, Hameed A (2016).
4354:
International Journal of Radiation Oncology, Biology, Physics
4262: 3746: 3252: 3181: 3179: 2958: 2387:
Armitage JO (August 2010). "Early-stage Hodgkin's lymphoma".
1868:, English snooker player, diagnosed in 2008 at the age of 16. 1862:
treatment in 1949; died from a burst abscess on his one lung.
746: 528: 515: 380: 345: 241: 225: 82: 5066: 4460: 1550:
Photograph of Hodgkin's disease from a 1938 medical textbook
7397: 7291: 7275:
Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
7270: 7188: 6930: 6905: 6885: 6881: 6768: 6686: 6681: 5364:"Bournemouth midfielder David Brooks diagnosed with cancer" 5024:
Mediterranean Journal of Hematology and Infectious Diseases
4314:"Brentuximab vedotin: An anti-CD30 antibody–drug conjugate" 3961: 3696: 3582: 3293: 1743:, British composer, was diagnosed in 1951 and died in 1956. 1337: 1242:
For Hodgkin lymphomas, radiation oncologists typically use
1090: 1051: 1004: 931: 927: 923: 717: 683: 4680: 4582: 3176: 3136:"Epstein-Barr virus-associated Hodgkin's lymphoma: Review" 3087:
Gobbi PG, Ferreri AJ, Ponzoni M, Levis A (February 2013).
2177:"Adult Hodgkin Lymphoma Treatment (PDQ) – Patient Version" 2113:"Adult Hodgkin Lymphoma Treatment (PDQ) – Patient Version" 1984:, American professional soccer player and a winner of the 1554:
Hodgkin lymphoma was first described in an 1832 report by
445:(usually excisional biopsy with microscopic examination). 261:
Epstein–Barr virus-associated lymphoproliferative diseases
7137: 7132: 7022: 2909: 2887:"Hodgkin Lymphoma Diagnosis | Tests for Hodgkin Lymphoma" 2530:
Ward E, DeSantis C, Robbins A, Kohler B, Jemal A (2014).
2529: 2443: 1509: 1505: 695: 691: 599:(B-NHL). This form also has the most favorable prognosis. 5656: 3846: 3474:((PDQ Pediatric Treatment Editorial Board (2022-04-08). 3424: 3086: 5325:"Microsoft co-founder Paul Allen diagnosed with cancer" 4988:
NCI Surveillance, Epidemiology, and End Results Program
4954:
Mauch P, Armitage J, Diehl V, Hoppe R, Weiss L (1999).
4953: 3996: 3544:"Epstein-Barr virus and the origin of Hodgkin lymphoma" 2302:
CO, Kassebaum NJ, Kinfu Y, Kulikoff XR (October 2016).
2019: 1928:. Diagnosed in March 2010 while he was a coach for the 1886:, health care activist diagnosed in 2017, spoke at the 224:, who first described it in 1832. Symptoms may include 3941: 3037: 2300: 1874:, Indian film actress and producer, diagnosed in 2010. 735:
After Hodgkin lymphoma is diagnosed, a person will be
6062:"FILM; An Italian Satirist Takes a Very Serious Turn" 4213: 1637:
and, later, it was one of the first to be treated by
251:. About half of cases of Hodgkin lymphoma are due to 6461: 5788:. 1st Ed. Praha: The World Circle Foundation, 2000. 4311: 3038:
Re D, Thomas RK, Behringer K, Diehl V (2005-06-15).
2249:
Kassebaum NJ, Kawashima T, Kemmer L (October 2016).
527:
Is the most common subtype and is composed of large
4045: 2776: 2747: 2745: 2247: 7345:Peripheral T-cell lymphoma not otherwise specified 4822: 4411: 3133: 2532:"Childhood and adolescent cancer statistics, 2014" 1836:and actor. Was diagnosed in 2002 while writing on 7167:Precursor T acute lymphoblastic leukemia/lymphoma 6721:Precursor B acute lymphoblastic leukemia/lymphoma 5585:. www.childhoodcancerresearch.org. Archived from 708: 7591: 6296:"Ethan Zohn is a survivor in more ways than one" 5685: 4730: 4080: 2742: 2446:Critical Reviews in Clinical Laboratory Sciences 2150:. World Health Organization. 2014. Chapter 2.4. 1787:, Czechoslovak theatre actor, poet, and composer 1737:, American tennis player, was diagnosed in 2014. 666:showing Hodgkin lymphoma, mixed-cellularity type 6911:Nodular lymphocyte predominant Hodgkin lymphoma 6381:Henry Kaplan and the Story of Hodgkin's Disease 6151:"'04 Red Sox hero Roberts treated for lymphoma" 6028:"Cancer fight gives Lisowski new angle on life" 4870: 4868: 4214:Küppers R, Engert A, Hansmann ML (2012-10-01). 3641:, Treasure Island (FL): StatPearls Publishing, 3632: 3531:. The Publishing House of the Romanian Academy. 3501:, Treasure Island (FL): StatPearls Publishing, 2708: 2706: 2704: 2702: 2171: 2169: 2167: 909:nodular lymphocyte predominant Hodgkin lymphoma 714:Nodular lymphocyte predominant Hodgkin lymphoma 476:nodular lymphocyte predominant Hodgkin lymphoma 286:, or lung disease over the subsequent decades. 249:nodular lymphocyte-predominant Hodgkin lymphoma 244:. Persons affected may feel tired or be itchy. 5532:"Teen, court reach agreement over cancer care" 5428: 5408:"Dale Carnagie page: strategies for influence" 4312:Bradley AM, Devine M, DeRemer D (2013-04-01). 4093:(8): 982–90, discussion 990, 996, 998 passim. 2420: 2418: 1749:, Icelandic football player and member of the 955:Pleomorphic RSC has multiple irregular nuclei. 678:For the other forms, although the traditional 7301:Secondary cutaneous CD30+ large-cell lymphoma 6633: 6326:"Richard Holliday completes cancer treatment" 6059: 5950:"Funnyman Sean Kent winning fight vs. cancer" 5278: 5276: 5274: 5272: 5270: 4771: 4115: 3492: 2723: 2486: 2107: 2105: 2103: 2101: 2099: 2097: 2095: 2093: 2091: 2015: 2013: 1697:, Egyptologist and discoverer of the Tomb of 1562:in 1666. While occupied as museum curator at 1027:. The abbreviation stands for the four drugs 745:, a physical examination, blood tests, chest 6991:Post-transplant lymphoproliferative disorder 6946:immunoproliferative immunoglobulin disorders 5762: 5734: 5657:Ásta Sigrún Magnúsdóttir (16 October 2015). 5504:(online ed.). Oxford University Press. 5232: 5209: 5207: 5205: 5203: 5201: 5199: 4865: 3840: 3528:TUMORS OF HEMATOPOIETIC AND LYMPHOID TISSUES 3287: 3246: 3205: 2830: 2802:Hilson AJ (July 1995). "Pel-Ebstein fever". 2699: 2667:"Alcohol-related pain and Hodgkin's disease" 2243: 2241: 2164: 2142: 2140: 2138: 1826:, Australian actress, was diagnosed in 2014. 240:occur in the neck, under the arm, or in the 7504:Diffuse infiltrative lymphocytosis syndrome 5999: 5469:. Tauris Parke Paperbacks. pp. 454–5. 5289:Journal of the National Medical Association 4638:The Cochrane Database of Systematic Reviews 4589:The Cochrane Database of Systematic Reviews 4540:The Cochrane Database of Systematic Reviews 4505:The Cochrane Database of Systematic Reviews 4390:. RTanswers.com. 2010-12-03. Archived from 3753:The Cochrane Database of Systematic Reviews 3704:The Cochrane Database of Systematic Reviews 3576: 3386:"Hodgkin Lymphoma: Diagnosis and Treatment" 3336: 3134:Gandhi MK, Tellam JT, Khanna R (May 2004). 2633: 2582:"Hodgkin Lymphoma: Diagnosis and Treatment" 2415: 2350: 2296: 2294: 1848:, Hall of Fame NHL player, co-owner of the 1487:increases with age, Hodgkin lymphoma has a 7543:Jessner lymphocytic infiltrate of the skin 7089:Primary cutaneous follicle center lymphoma 6834:Primary cutaneous follicle center lymphoma 6640: 6626: 6349: 6229:"Specter diagnosed with Hodgkin's disease" 5267: 4925:"WHO Disease and injury country estimates" 4318:American Journal of Health-System Pharmacy 2210: 2208: 2206: 2204: 2202: 2088: 2010: 546:with varying degrees of collagen fibrosis/ 401:is high enough for it to be regarded as a 40: 5896:"Tessa James reveals she is in remission" 5558:"James Conner Announces Cancer Diagnosis" 5300: 5213: 5196: 5092: 5043: 4976: 4892: 4848: 4799: 4789: 4748: 4699: 4657: 4608: 4559: 4478: 4437: 4288: 4239: 4182: 4133: 4014: 3913: 3864: 3823: 3813: 3772: 3723: 3663: 3661: 3609: 3559: 3535: 3524: 3442: 3401: 3360: 3311: 3270: 3229: 3151: 3055: 2976: 2935: 2862: 2682: 2597: 2547: 2424: 2382: 2380: 2378: 2327: 2274: 2238: 2216:"SEER Stat Fact Sheets: Hodgkin Lymphoma" 2135: 2063: 2045: 1583:Medical and Chirurgical Society of London 1021:The original treatment for Hodgkin's was 486:and the composition of the reactive cell 7069:Primary cutaneous marginal zone lymphoma 6867:Primary cutaneous marginal zone lymphoma 6323: 6174: 6168: 6125:"Emma: Anthony Rizzo's Indelible Impact" 5947: 5716:"Delta Goodrem Hospitalized With Cancer" 5429:Stovall J, Johnson K (6 February 2024). 4731:Hasenclever D, Diehl V (November 1998). 4412:Moding EJ, Kastan MB, Kirsch DG (2013). 4081:Klimm B, Diehl V, Engert A (July 2007). 3938:"Home | German Hodgkin Study Group" 3004: 2386: 2291: 1721:and 2014 ACC Player of the Year for the 1587:Medical-Chirurgical Society Transactions 1545: 1379: 1239:but still existing refractory patients. 899: 888: 669: 657: 482:subtypes based upon Reed–Sternberg cell 7531:with bandlike and perivascular patterns 7493:Autoimmune lymphoproliferative syndrome 5898:. Yahoo! News Australia. Archived from 5501:Oxford Dictionary of National Biography 3093:Critical Reviews in Oncology/Hematology 2664: 2480: 2437: 2199: 1689:How to Win Friends and Influence People 1289: 7592: 7340:Enteropathy-associated T-cell lymphoma 6378: 6249: 6131:from the original on 14 September 2015 5466:Howard Carter: The Path to Tutankhamun 5282: 5238: 4164: 4116:Townsend W, Linch D (September 2012). 3658: 3383: 2801: 2726:Cancer: A Comprehensive Clinical Guide 2579: 2375: 1701:, died in 1939 from Hodgkin's disease. 16:Type of blood and immune-system cancer 6621: 5805: 5493: 5462: 5173: 5171: 5013: 5011: 5009: 3692: 3690: 3000: 2998: 2996: 2629: 2627: 2625: 2623: 2621: 2619: 2617: 2575: 2573: 2571: 2569: 2567: 1360:, and bulky disease (widening of the 498:comparison in nodular sclerosing HL. 293: 266:Hodgkin lymphoma may be treated with 35:Hodgkin's lymphoma, Hodgkin's disease 7488:X-linked lymphoproliferative disease 5688:"Ótrúleg endurkoma eftir röð áfalla" 5686:Gunnar Birgisson (11 October 2020). 5156:from the original on 17 October 2014 4994:from the original on 17 October 2012 4829:Pakistan Journal of Medical Sciences 4674: 2757:The Lecturio Medical Concept Library 2357:(2nd ed.). Wiley. p. 195. 2226:from the original on 17 October 2012 1924:, MLB outfielder and manager of the 1395:per 100,000 inhabitants in 2004 474:Classic Hodgkin lymphoma (excluding 7444:Large granular lymphocytic leukemia 7064:Intravascular large B-cell lymphoma 5837:"Lionhearted—Death, Richard Harris" 5346:"Eric Berry has Hodgkin's lymphoma" 4737:The New England Journal of Medicine 4688:The New England Journal of Medicine 2804:The New England Journal of Medicine 2536:CA: A Cancer Journal for Clinicians 2389:The New England Journal of Medicine 1888:2020 Democratic National Convention 457:may be used instead of a PET scan. 208:originates from a specific type of 13: 6372: 6002:"Dinu Lipatti: Prince of Pianists" 5872:. Associated Press. May 16, 2009. 5168: 5006: 3802:World Journal of Clinical Oncology 3687: 2993: 2646:from the original on June 28, 2009 2614: 2564: 1257: 1227:The common non-Hodgkin treatment, 14: 7626: 6411: 5981:from the original on 3 April 2013 5876:from the original on May 31, 2015 4984:"SEER Stat Fact Sheets: Leukemia" 4960:Lippincott Williams & Wilkins 4220:Journal of Clinical Investigation 3480:PDQ Cancer Information Summaries 2187:from the original on 28 July 2016 2123:from the original on 28 July 2016 478:) can be subclassified into four 7615:Diseases named after discoverers 6343: 6317: 6288: 6262: 6243: 6221: 6195: 6143: 6117: 6095: 6081: 6053: 6042: 6020: 6004:. markainley.com. Archived from 5993: 5967: 5913: 5888: 5858: 5829: 5799: 5778: 5756: 5625:from the original on 2016-01-12. 5619:"Victoria Duval battling cancer" 5483:from the original on 2017-09-10. 5386:"Dale Carnagie at Biography.com" 5352:from the original on 2015-03-08. 4105:from the original on 2009-05-12. 3602:10.1182/bloodadvances.2019001012 3153:10.1111/j.1365-2141.2004.04902.x 3105:10.1016/j.critrevonc.2012.07.002 2371:from the original on 2017-09-10. 1839:The Best Damn Sports Show Period 1687:, Public Speaker and author of " 1644: 1532: 896:of a classic Reed–Sternberg cell 847: 835: 823: 811: 778:Ann Arbor staging classification 280:survive for five years or longer 7296:CD30+ cutaneous T-cell lymphoma 6210:from the original on 2015-10-26 5948:Chandler R (28 November 2007). 5818:from the original on 2015-02-08 5763:vlogbrothers (25 August 2023), 5728: 5708: 5679: 5650: 5629: 5611: 5600: 5575: 5550: 5524: 5487: 5456: 5422: 5400: 5378: 5356: 5338: 5317: 5138: 5109: 5060: 4947: 4935:from the original on 2009-11-11 4917: 4816: 4765: 4724: 4625: 4576: 4527: 4495: 4454: 4405: 4380: 4344: 4305: 4256: 4207: 4158: 4109: 4074: 4039: 3990: 3955: 3930: 3889: 3789: 3740: 3626: 3518: 3486: 3467: 3418: 3377: 3259:International Journal of Cancer 3214:"Biology of Hodgkin's lymphoma" 3127: 3080: 3031: 2952: 2903: 2879: 2795: 2770: 2671:The Western Journal of Medicine 2658: 2523: 1765:, one of the cofounders of the 1751:Icelandic women's national team 1375: 1244:external beam radiation therapy 874:) a nodular aspect may appear. 7526:Cutaneous lymphoid hyperplasia 7518:Cutaneous lymphoid hyperplasia 7377:Adult T-cell leukemia/lymphoma 7255:Adult T-cell leukemia/lymphoma 7194:Anaplastic large-cell lymphoma 7074:Primary cutaneous immunocytoma 7015:Splenic marginal zone lymphoma 6302:. 18 June 2014. Archived from 5667:(in Icelandic). pp. 30–31 5241:Annals of Diagnostic Pathology 4650:10.1002/14651858.CD009075.pub3 4601:10.1002/14651858.CD009768.pub2 4552:10.1002/14651858.CD010983.pub2 4513:10.1002/14651858.CD004269.pub3 4418:Nature Reviews. Drug Discovery 4171:American Journal of Hematology 4118:"Hodgkin's lymphoma in adults" 3765:10.1002/14651858.CD007110.pub3 3716:10.1002/14651858.CD012643.pub3 3633:Aggarwal P, Limaiem F (2022), 3140:British Journal of Haematology 2965:British Journal of Haematology 2344: 1358:erythrocyte sedimentation rate 1031:(also known as chlormethine), 709:Nodular lymphocyte predominant 623:anaplastic large cell lymphoma 167:574,000 (affected during 2015) 1: 7574:Lymphoproliferative disorders 7484:Lymphoproliferative disorders 7434:Extranodal NK-T-cell lymphoma 7306:Lymphomatoid papulosis type A 7285:Lymphomatoid papulosis type B 7199:Lymphomatoid papulosis type A 7059:Diffuse large B-cell lymphoma 5659:"Vá, hvað get ég gert meira?" 5366:. Sky Sports. 13 October 2021 5253:10.1016/S1092-9134(99)80018-5 5146:"Hodgkin lymphoma statistics" 4135:10.1016/S0140-6736(12)60035-X 2501:10.1016/j.humpath.2018.05.020 2458:10.1080/10408363.2017.1422692 2320:10.1016/s0140-6736(16)31012-1 2267:10.1016/S0140-6736(16)31678-6 2038:10.1016/S0140-6736(12)61728-0 2003: 1880:, Italian actor and director. 1797:, in Showtime's crime series 1035:(also known as vincristine), 972: 884: 864: 7466:Acute biphenotypic leukaemia 7355:Subcutaneous T-cell lymphoma 5735:vlogbrothers (19 May 2023). 5518:UK public library membership 5496:"Carter, Howard (1874–1939)" 5117:"Canadian Cancer Statistics" 5085:10.1182/blood-2006-05-024109 4366:10.1016/j.ijrobp.2013.05.005 4060:10.1097/CCO.0000000000000464 3853:Journal of Clinical Oncology 3493:Sapkota S, Shaikh H (2022), 3403:10.1016/j.mayocp.2015.07.005 3362:10.1182/blood-2008-01-134783 2855:10.1182/blood-2009-11-251132 2599:10.1016/j.mayocp.2015.07.005 1809:, Irish actor who portrayed 1485:number of new cases per year 1298: 859: 755:positron emission tomography 571:Epstein-Barr virus infection 451:Positron emission tomography 436: 7: 7605:Infectious causes of cancer 7407:Aggressive NK-cell leukemia 7280:Pleomorphic T-cell lymphoma 6986:Lymphomatoid granulomatosis 6350:Czaplewski R (2023-09-30). 6175:Chasnoff B (May 13, 2018). 6127:. CBS Chicago. 8 May 2014. 4881:Journal of Nuclear Medicine 4750:10.1056/NEJM199811193392104 3431:Journal of Nuclear Medicine 2816:10.1056/NEJM199507063330118 2580:Ansell SM (November 2015). 619:diffuse large cell lymphoma 10: 7631: 6324:Thompson A (17 Feb 2023). 6105:(in Croatian). 8 June 2017 6091:. Denver Post. 2020-08-18. 5975:"Mario Lemieux Foundation" 4016:10.1182/blood-2002-08-2644 3976:10.1016/j.ctrv.2010.11.005 3940:. Ghsg.org. Archived from 3187:"HMDS: Hodgkin's Lymphoma" 3057:10.1182/blood-2004-12-4750 3005:Swerdlow SH (2017-09-18). 2351:Bower M, Waxman J (2011). 1541: 759:magnetic resonance imaging 727: 469: 52:showing Hodgkin lymphoma ( 7551: 7516: 7474: 7456: 7420: 7390: 7363: 7318: 7263: 7217: 7208: 7148: 7110: 7101: 7049: 6959: 6920: 6876: 6798: 6767: 6729: 6708: 6697: 6664: 6660: 6569: 6465: 6457:National Cancer Institute 6385:Stanford University Press 5954:www.tahoedailytribune.com 5283:Geller SA (August 1984). 4929:World Health Organisation 4894:10.2967/jnumed.112.110890 4467:Human Reproduction Update 3548:Chinese Journal of Cancer 3525:Baba AI, Câtoi C (2007). 3444:10.2967/jnumed.109.064121 3313:10.1038/modpathol.3800473 2640:Merck Manual Professional 2634:Portlock CS (July 2008). 1705:Starchild Abraham Cherrix 1515: 987:progression-free survival 780:scheme is a common one): 565:Mixed-cellularity subtype 399:positive predictive value 397:. On the other hand, its 276:stem-cell transplantation 179: 171: 163: 150: 128: 116: 100: 76: 60: 48: 39: 31: 26: 7559:Hematological malignancy 7412:Blastic NK cell lymphoma 7240:Granulomatous slack skin 6996:Classic Hodgkin lymphoma 6895:Classic Hodgkin lymphoma 6181:San Antonio Express-News 5637:"Gerald Finzi biography" 4791:10.4103/0366-6999.194661 3964:Cancer Treatment Reviews 2728:. Taylor & Francis. 2665:Bobrove AM (June 1983). 2148:World Cancer Report 2014 1669:National Football League 1639:combination chemotherapy 1283:or pelvic radiotherapy. 991:combination chemotherapy 854:Stage 4 Hodgkin lymphoma 842:Stage 3 Hodgkin lymphoma 830:Stage 2 Hodgkin lymphoma 818:Stage 1 Hodgkin lymphoma 460: 6448:American Cancer Society 6429:considered for deletion 6250:Carter B (1997-08-28). 6231:. CNN. 16 February 2005 4841:10.12669/pjms.326.11080 4778:Chinese Medical Journal 4165:Ansell SM (July 2014). 3866:10.1200/JCO.2005.02.907 3390:Mayo Clinic Proceedings 3231:10.1093/annonc/13.S1.11 2928:10.1126/science.abb9601 2586:Mayo Clinic Proceedings 2354:Lecture Notes: Oncology 1773:and production company 1306:five-year survival rate 216:, where multinucleated 157:Five-year survival rate 6356:www.rickczaplewski.com 6060:Laura Winters (2002). 5925:Columbia Daily Tribune 5806:Huver S (2010-07-23). 5510:10.1093/ref:odnb/32312 5036:10.4084/mjhid.2014.048 3635:"Reed Sternberg Cells" 3495:"Non-Hodgkin Lymphoma" 2724:John Kearsley (1998). 1954:Minnesota Timberwolves 1551: 1476: 1334:< 600/μL or < 8% 1252:mantle field radiation 915: 897: 701:Hodgkin cells produce 675: 667: 427:minimal change disease 7438:Angiocentric lymphoma 7028:AIDS-related lymphoma 6852:Splenic marginal zone 5737:"So, I've got cancer" 4480:10.1093/humupd/dmr038 4281:10.1093/annonc/mdu181 3915:10.1093/annonc/mdp337 3815:10.5306/wjco.v4.i2.47 2401:10.1056/NEJMra1003733 2047:10536/DRO/DU:30050819 1549: 1524: 1383: 903: 892: 879:fibrin ring granuloma 673: 661: 523:Nodular sclerosing HL 379:: Enlargement of the 369:: Enlargement of the 7536:with nodular pattern 7235:Pagetoid reticulosis 6847:marginal zone B-cell 6000:Mark Ainley (2002). 5348:. ESPN. 2014-12-08. 4701:10.1056/NEJMoa064601 2314:(10053): 1459–1544. 2261:(10053): 1545–1602. 1972:Bernardo Tengarrinha 1938:, Texas congressman. 1900:, diagnosed in 2015. 1671:, diagnosed in 2014. 1620:non-Hodgkin lymphoma 1473: more than 19.8 1290:Supportive treatment 1056:chemotherapy regimen 967:non-Hodgkin lymphoma 920:Reed-Sternberg cells 597:non-Hodgkin lymphoma 238:enlarged lymph nodes 236:. Often, nonpainful 218:Reed–Sternberg cells 141:stem-cell transplant 95:enlarged lymph nodes 7035:Helicobacter pylori 6862:Nodal marginal zone 6789:Hairy cell leukemia 6655:and related disease 5786:Nevyjasněná úmrtí V 1926:Los Angeles Dodgers 1850:Pittsburgh Penguins 1815:Harry Potter movies 1407: less than 1.8 751:computed tomography 614:Lymphocyte depleted 7579:Lymphoid leukemias 7499:Leukemoid reaction 7335:Angioimmunoblastic 7001:Burkitt's lymphoma 6570:External resources 6379:Jacobs CD (2010). 6256:The New York Times 6067:The New York Times 6038:on April 30, 2013. 6008:on 22 October 2015 5870:The New York Times 5463:James TG (2012) . 5150:Cancer Research UK 4962:. pp. 62–64. 4503:transplantation". 4330:10.2146/ajhp110608 4269:Annals of Oncology 4216:"Hodgkin lymphoma" 3902:Annals of Oncology 3669:"Hodgkin lymphoma" 3218:Annals of Oncology 3089:"Hodgkin lymphoma" 2922:(6499): eabb9601. 2753:"Hodgkin Lymphoma" 2718:2015-09-20 at the 2636:"Hodgkin Lymphoma" 2549:10.3322/caac.21219 2183:. August 3, 2016. 2119:. August 3, 2016. 2032:(9859): 2095–128. 1896:, Croatian soccer 1781:on 25 August 2023. 1747:Mist Edvardsdóttir 1665:Kansas City Chiefs 1552: 1477: 1277:growth retardation 916: 898: 676: 668: 423:Nephrotic syndrome 387:Hepatosplenomegaly 294:Signs and symptoms 253:Epstein–Barr virus 109:, family history, 107:Epstein–Barr virus 7587: 7586: 7512: 7511: 7452: 7451: 7386: 7385: 7314: 7313: 7230:Mycosis fungoides 7097: 7096: 6955: 6954: 6899:Nodular sclerosis 6814:follicular B cell 6615: 6614: 6394:978-0-8047-7448-2 6276:. 30 October 2021 6183:. ExpressNews.com 5784:Skálová, Johana. 5516:(Subscription or 5476:978-1-84511-258-5 5442:978-1-64095-416-8 5410:. 6 February 2024 5388:. 6 February 2024 5225:978-0-7817-6422-3 4969:978-0-7817-1502-7 4956:Hodgkin's Disease 4226:(10): 3439–3447. 4184:10.1002/ajh.23750 4128:(9844): 836–847. 4009:(11): 4285–4289. 3675:. 23 October 2017 3596:(23): 4065–4080. 3396:(11): 1574–1583. 3384:Ansell S (2015). 3272:10.1002/ijc.21716 3224:(Suppl 1): 11–8. 3016:978-92-832-4494-3 2978:10.1111/bjh.13842 2788:978-0-7817-6422-3 2779:Hodgkin's disease 2735:978-90-5702-215-9 2364:978-1-118-29300-3 1966:Brandon Tartikoff 1834:stand up comedian 1813:in the first two 1723:Arizona Cardinals 1635:radiation therapy 1574:, and one was of 1560:Marcello Malpighi 1494:nodular sclerosis 1349:White blood count 1281:alkylating agents 1267:, lymphomas, and 1225: 1224: 982:radiation therapy 872:nodular sclerosis 690:markers (such as 682:markers (such as 656: 655: 417:Pel–Ebstein fever 272:radiation therapy 191: 190: 137:radiation therapy 123:Lymph node biopsy 118:Diagnostic method 21:Medical condition 7622: 7600:Hodgkin lymphoma 7349:Lennert lymphoma 7215: 7214: 7146: 7145: 7108: 7107: 6973:Primary effusion 6706: 6705: 6695: 6694: 6662: 6661: 6642: 6635: 6628: 6619: 6618: 6606:Hodgkin lymphoma 6463: 6462: 6455:at the American 6453:Hodgkin Lymphoma 6444:Hodgkin Lymphoma 6435:Hodgkin lymphoma 6432: 6406: 6366: 6365: 6363: 6362: 6347: 6341: 6340: 6338: 6336: 6321: 6315: 6314: 6312: 6311: 6292: 6286: 6285: 6283: 6281: 6266: 6260: 6259: 6247: 6241: 6240: 6238: 6236: 6225: 6219: 6218: 6216: 6215: 6199: 6193: 6192: 6190: 6188: 6172: 6166: 6165: 6163: 6162: 6147: 6141: 6140: 6138: 6136: 6121: 6115: 6114: 6112: 6110: 6099: 6093: 6092: 6085: 6079: 6078: 6076: 6074: 6057: 6051: 6046: 6040: 6039: 6034:. 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Sound Wisdom. 5426: 5420: 5419: 5417: 5415: 5404: 5398: 5397: 5395: 5393: 5382: 5376: 5375: 5373: 5371: 5360: 5354: 5353: 5342: 5336: 5335: 5333: 5332: 5321: 5315: 5314: 5304: 5280: 5265: 5264: 5236: 5230: 5229: 5216:Hodgkin Lymphoma 5211: 5194: 5193: 5191: 5190: 5179:"Lymphoma | CDC" 5175: 5166: 5165: 5163: 5161: 5142: 5136: 5135: 5133: 5132: 5123:. Archived from 5113: 5107: 5106: 5096: 5064: 5058: 5057: 5047: 5015: 5004: 5003: 5001: 4999: 4980: 4974: 4973: 4951: 4945: 4944: 4942: 4940: 4921: 4915: 4914: 4896: 4872: 4863: 4862: 4852: 4820: 4814: 4813: 4803: 4793: 4769: 4763: 4762: 4752: 4728: 4722: 4721: 4703: 4678: 4672: 4671: 4661: 4629: 4623: 4622: 4612: 4580: 4574: 4573: 4563: 4546:(11): CD010983. 4531: 4525: 4524: 4499: 4493: 4492: 4482: 4458: 4452: 4451: 4441: 4409: 4403: 4402: 4400: 4399: 4384: 4378: 4377: 4348: 4342: 4341: 4309: 4303: 4302: 4292: 4260: 4254: 4253: 4243: 4232:10.1172/jci61245 4211: 4205: 4204: 4186: 4162: 4156: 4155: 4137: 4113: 4107: 4106: 4078: 4072: 4071: 4043: 4037: 4036: 4018: 3994: 3988: 3987: 3959: 3953: 3952: 3950: 3949: 3934: 3928: 3927: 3917: 3893: 3887: 3886: 3868: 3859:(36): 9198–207. 3844: 3838: 3837: 3827: 3817: 3793: 3787: 3786: 3776: 3744: 3738: 3737: 3727: 3694: 3685: 3684: 3682: 3680: 3665: 3656: 3655: 3654: 3653: 3630: 3624: 3623: 3613: 3580: 3574: 3573: 3563: 3539: 3533: 3532: 3522: 3516: 3515: 3514: 3513: 3490: 3484: 3483: 3471: 3465: 3464: 3446: 3422: 3416: 3415: 3405: 3381: 3375: 3374: 3364: 3340: 3334: 3333: 3315: 3300:Modern Pathology 3291: 3285: 3284: 3274: 3250: 3244: 3243: 3233: 3209: 3203: 3202: 3200: 3198: 3193:on March 4, 2009 3189:. Archived from 3183: 3174: 3173: 3155: 3131: 3125: 3124: 3084: 3078: 3077: 3059: 3035: 3029: 3028: 3002: 2991: 2990: 2980: 2956: 2950: 2949: 2939: 2907: 2901: 2900: 2898: 2897: 2883: 2877: 2876: 2866: 2834: 2828: 2827: 2799: 2793: 2792: 2774: 2768: 2767: 2765: 2763: 2749: 2740: 2739: 2710: 2697: 2696: 2686: 2662: 2656: 2655: 2653: 2651: 2631: 2612: 2611: 2601: 2577: 2562: 2561: 2551: 2527: 2521: 2520: 2484: 2478: 2477: 2441: 2435: 2434: 2422: 2413: 2412: 2384: 2373: 2372: 2348: 2342: 2341: 2331: 2298: 2289: 2288: 2278: 2245: 2236: 2235: 2233: 2231: 2212: 2197: 2196: 2194: 2192: 2173: 2162: 2161: 2144: 2133: 2132: 2130: 2128: 2109: 2086: 2085: 2067: 2049: 2017: 1994:Richard Holliday 1930:San Diego Padres 1912:New York Yankees 1811:Albus Dumbledore 1729:Michael Cuccione 1601:Theodor Langhans 1472: 1466: 1460: 1454: 1448: 1442: 1436: 1430: 1424: 1418: 1412: 1406: 1400: 1393:multiple myeloma 1385:Age-standardized 1332:Lymphocyte count 1322:Stage IV disease 1184:Cyclophosphamide 996: 995: 851: 839: 827: 815: 501: 500: 319:chest radiograph 210:white blood cell 194:Hodgkin lymphoma 44: 27:Hodgkin lymphoma 24: 23: 7630: 7629: 7625: 7624: 7623: 7621: 7620: 7619: 7590: 7589: 7588: 7583: 7547: 7508: 7470: 7458: 7448: 7416: 7395: 7382: 7359: 7320: 7310: 7259: 7204: 7152: 7150: 7125: 7120: 7114: 7093: 7045: 6951: 6928: 6916: 6872: 6810:germinal center 6794: 6763: 6725: 6701: 6699: 6679: 6674: 6668: 6656: 6646: 6616: 6611: 6610: 6565: 6564: 6528:: 9650/3-9667/3 6474: 6417: 6414: 6395: 6375: 6373:Further reading 6370: 6369: 6360: 6358: 6348: 6344: 6334: 6332: 6322: 6318: 6309: 6307: 6300:Chicago Tribune 6294: 6293: 6289: 6279: 6277: 6268: 6267: 6263: 6248: 6244: 6234: 6232: 6227: 6226: 6222: 6213: 6211: 6202: 6200: 6196: 6186: 6184: 6173: 6169: 6160: 6158: 6149: 6148: 6144: 6134: 6132: 6123: 6122: 6118: 6108: 6106: 6101: 6100: 6096: 6087: 6086: 6082: 6072: 6070: 6058: 6054: 6047: 6043: 6032:Daily Telegraph 6026: 6025: 6021: 6011: 6009: 5998: 5994: 5984: 5982: 5973: 5972: 5968: 5958: 5956: 5946: 5939: 5929: 5927: 5919: 5918: 5914: 5905: 5903: 5894: 5893: 5889: 5879: 5877: 5864: 5863: 5859: 5850: 5848: 5835: 5834: 5830: 5821: 5819: 5804: 5800: 5783: 5779: 5771: 5769: 5761: 5757: 5747: 5745: 5733: 5729: 5714: 5713: 5709: 5699: 5697: 5684: 5680: 5670: 5668: 5664:Dagblaðið Vísir 5655: 5651: 5641: 5639: 5635: 5634: 5630: 5617: 5616: 5612: 5605: 5601: 5592: 5590: 5581: 5580: 5576: 5567: 5565: 5556: 5555: 5551: 5541: 5539: 5530: 5529: 5525: 5515: 5492: 5488: 5477: 5461: 5457: 5447: 5445: 5443: 5427: 5423: 5413: 5411: 5406: 5405: 5401: 5391: 5389: 5384: 5383: 5379: 5369: 5367: 5362: 5361: 5357: 5344: 5343: 5339: 5330: 5328: 5323: 5322: 5318: 5281: 5268: 5237: 5233: 5226: 5212: 5197: 5188: 5186: 5177: 5176: 5169: 5159: 5157: 5144: 5143: 5139: 5130: 5128: 5115: 5114: 5110: 5079:(12): 3786–91. 5065: 5061: 5030:(1): e2014048. 5016: 5007: 4997: 4995: 4982: 4981: 4977: 4970: 4952: 4948: 4938: 4936: 4923: 4922: 4918: 4873: 4866: 4821: 4817: 4770: 4766: 4743:(21): 1506–14. 4729: 4725: 4694:(19): 1916–27. 4679: 4675: 4644:(1): CD009075. 4630: 4626: 4595:(1): CD009768. 4581: 4577: 4532: 4528: 4507:(5): CD004269. 4500: 4496: 4459: 4455: 4430:10.1038/nrd4003 4410: 4406: 4397: 4395: 4388:"RTanswers.com" 4386: 4385: 4381: 4349: 4345: 4310: 4306: 4261: 4257: 4212: 4208: 4163: 4159: 4114: 4110: 4079: 4075: 4048:Curr Opin Oncol 4044: 4040: 3995: 3991: 3960: 3956: 3947: 3945: 3936: 3935: 3931: 3894: 3890: 3845: 3841: 3794: 3790: 3759:(4): CD007110. 3745: 3741: 3710:(8): CD012643. 3695: 3688: 3678: 3676: 3667: 3666: 3659: 3651: 3649: 3631: 3627: 3581: 3577: 3540: 3536: 3523: 3519: 3511: 3509: 3491: 3487: 3472: 3468: 3423: 3419: 3382: 3378: 3341: 3337: 3292: 3288: 3251: 3247: 3210: 3206: 3196: 3194: 3185: 3184: 3177: 3132: 3128: 3085: 3081: 3050:(12): 4553–60. 3036: 3032: 3017: 3003: 2994: 2957: 2953: 2908: 2904: 2895: 2893: 2885: 2884: 2880: 2849:(18): 3756–62. 2835: 2831: 2800: 2796: 2789: 2775: 2771: 2761: 2759: 2751: 2750: 2743: 2736: 2720:Wayback Machine 2711: 2700: 2663: 2659: 2649: 2647: 2632: 2615: 2592:(11): 1574–83. 2578: 2565: 2528: 2524: 2489:Human Pathology 2485: 2481: 2442: 2438: 2423: 2416: 2385: 2376: 2365: 2349: 2345: 2299: 2292: 2246: 2239: 2229: 2227: 2214: 2213: 2200: 2190: 2188: 2175: 2174: 2165: 2158: 2157:978-928320429-9 2146: 2145: 2136: 2126: 2124: 2111: 2110: 2089: 2018: 2011: 2006: 1906:, MLB All-Star 1894:Nikola Pokrivač 1791:Michael C. Hall 1709:medical neglect 1679:AFC Bournemouth 1647: 1616:histopathologic 1576:Robert Carswell 1544: 1535: 1527: 1518: 1512:T cell counts. 1481:other lymphomas 1475: 1474: 1470: 1468: 1464: 1462: 1458: 1456: 1455: 14.4–16.2 1452: 1450: 1449: 12.6–14.4 1446: 1444: 1443: 10.8–12.6 1440: 1438: 1434: 1432: 1428: 1426: 1422: 1420: 1416: 1414: 1410: 1408: 1404: 1402: 1398: 1378: 1301: 1292: 1260: 1258:Adverse effects 1049:Currently, the 975: 887: 867: 862: 855: 852: 843: 840: 831: 828: 819: 816: 730: 711: 472: 463: 439: 315:supraclavicular 303:Lymphadenopathy 296: 200:) is a type of 22: 17: 12: 11: 5: 7628: 7618: 7617: 7612: 7607: 7602: 7585: 7584: 7582: 7581: 7576: 7571: 7569:Leukemia cutis 7566: 7561: 7555: 7553: 7549: 7548: 7546: 7545: 7540: 7539: 7538: 7533: 7522: 7520: 7514: 7513: 7510: 7509: 7507: 7506: 7501: 7496: 7490: 7480: 7478: 7472: 7471: 7469: 7468: 7462: 7460: 7454: 7453: 7450: 7449: 7447: 7446: 7441: 7424: 7422: 7418: 7417: 7415: 7414: 7409: 7403: 7401: 7388: 7387: 7384: 7383: 7381: 7380: 7367: 7365: 7361: 7360: 7358: 7357: 7352: 7342: 7337: 7332: 7326: 7324: 7316: 7315: 7312: 7311: 7309: 7308: 7303: 7298: 7288: 7287: 7282: 7277: 7267: 7265: 7261: 7260: 7258: 7257: 7249:Sézary disease 7243: 7242: 7237: 7232: 7223: 7221: 7212: 7206: 7205: 7203: 7202: 7196: 7184: 7183: 7180:Prolymphocytic 7170: 7156: 7154: 7143: 7142: 7141: 7135: 7105: 7099: 7098: 7095: 7094: 7092: 7091: 7086: 7081: 7076: 7071: 7066: 7061: 7055: 7053: 7047: 7046: 7044: 7043: 7031: 7019: 7018: 7017: 7005: 7004: 7003: 6998: 6993: 6988: 6976: 6963: 6961: 6957: 6956: 6953: 6952: 6950: 6949: 6940: 6938: 6918: 6917: 6915: 6914: 6902: 6891: 6889: 6874: 6873: 6871: 6870: 6864: 6859: 6854: 6838: 6837: 6831: 6826: 6821: 6805: 6803: 6796: 6795: 6793: 6792: 6780: 6778:Prolymphocytic 6774: 6772: 6765: 6764: 6762: 6761: 6749: 6736: 6734: 6727: 6726: 6724: 6714: 6712: 6703: 6692: 6691: 6690: 6658: 6657: 6645: 6644: 6637: 6630: 6622: 6613: 6612: 6609: 6608: 6597: 6586: 6574: 6573: 6571: 6567: 6566: 6563: 6562: 6551: 6540: 6529: 6521: 6506: 6491: 6475: 6470: 6469: 6467: 6466:Classification 6460: 6459: 6450: 6441: 6413: 6412:External links 6410: 6409: 6408: 6393: 6374: 6371: 6368: 6367: 6342: 6330:Post Wrestling 6316: 6287: 6261: 6242: 6220: 6206:. abc.go.com. 6194: 6167: 6142: 6116: 6094: 6080: 6052: 6049:Mamta Mohandas 6041: 6019: 5992: 5966: 5937: 5912: 5887: 5857: 5828: 5798: 5777: 5755: 5727: 5707: 5696:(in Icelandic) 5678: 5649: 5628: 5621:. 2014-07-04. 5610: 5599: 5574: 5549: 5523: 5486: 5475: 5455: 5441: 5421: 5399: 5377: 5355: 5337: 5316: 5266: 5231: 5224: 5195: 5167: 5137: 5108: 5059: 5005: 4975: 4968: 4946: 4916: 4864: 4835:(6): 1408–13. 4815: 4784:(23): 2780–5. 4764: 4723: 4673: 4624: 4575: 4526: 4494: 4453: 4424:(7): 526–542. 4404: 4379: 4343: 4324:(7): 589–597. 4304: 4255: 4206: 4177:(7): 771–779. 4157: 4108: 4073: 4054:(5): 308–316. 4038: 3989: 3954: 3929: 3908:(3): 574–581. 3888: 3839: 3788: 3739: 3686: 3657: 3625: 3590:Blood Advances 3575: 3534: 3517: 3485: 3466: 3437:(10): 1594–7. 3417: 3376: 3355:(8): 3339–47. 3335: 3306:(12): 1542–9. 3286: 3265:(8): 1853–61. 3245: 3204: 3175: 3146:(3): 267–281. 3126: 3099:(2): 216–237. 3079: 3030: 3015: 2992: 2951: 2902: 2891:www.cancer.org 2878: 2829: 2794: 2787: 2769: 2741: 2734: 2698: 2657: 2613: 2563: 2522: 2479: 2452:(2): 102–114. 2436: 2427:Med Chir Trans 2414: 2395:(7): 653–662. 2374: 2363: 2343: 2290: 2237: 2222:. April 2016. 2198: 2163: 2156: 2134: 2087: 2008: 2007: 2005: 2002: 2001: 2000: 1997: 1991: 1979: 1969: 1963: 1957: 1939: 1933: 1919: 1916:Boston Red Sox 1901: 1891: 1881: 1875: 1872:Mamta Mohandas 1869: 1863: 1853: 1843: 1827: 1821: 1818: 1807:Richard Harris 1804: 1788: 1785:Jiří Grossmann 1782: 1760: 1754: 1744: 1738: 1735:Victoria Duval 1732: 1726: 1712: 1702: 1692: 1682: 1672: 1654: 1646: 1643: 1605:Carl Sternberg 1572:Thomas Addison 1568:Richard Bright 1564:Guy's Hospital 1556:Thomas Hodgkin 1543: 1540: 1534: 1531: 1526: 1523: 1517: 1514: 1469: 1463: 1457: 1451: 1445: 1439: 1433: 1427: 1421: 1415: 1409: 1403: 1397: 1396: 1377: 1374: 1353: 1352: 1346: 1340: 1335: 1329: 1328:< 10.5 g/dl 1323: 1320: 1319:Age ≥ 45 years 1300: 1297: 1291: 1288: 1259: 1256: 1223: 1222: 1217: 1212: 1210: 1207: 1206: 1201: 1196: 1194: 1191: 1190: 1181: 1176: 1171: 1165: 1164: 1159: 1150: 1145: 1139: 1138: 1133: 1128: 1123: 1117: 1116: 1111: 1106: 1101: 1095: 1094: 1083: 1075: 1047: 1018: 1017: 1012: 1007: 1002: 974: 971: 963: 962: 959: 956: 953: 950: 886: 883: 866: 863: 861: 858: 857: 856: 853: 846: 844: 841: 834: 832: 829: 822: 820: 817: 810: 803: 802: 799: 792: 785: 767:lymphangiogram 729: 726: 710: 707: 703:interleukin-21 654: 653: 648: 643: 641: 637: 636: 631: 626: 615: 611: 610: 605: 600: 593: 586: 585: 579: 574: 566: 562: 561: 556: 551: 525: 519: 518: 513: 508: 505: 471: 468: 462: 459: 438: 435: 434: 433: 430: 420: 413: 407: 390: 384: 374: 364: 363: 362: 355: 349: 342: 335: 330: 322: 295: 292: 222:Thomas Hodgkin 189: 188: 186:Thomas Hodgkin 183: 177: 176: 173: 169: 168: 165: 161: 160: 154: 148: 147: 130: 126: 125: 120: 114: 113: 104: 98: 97: 80: 74: 73: 64: 58: 57: 46: 45: 37: 36: 33: 29: 28: 20: 15: 9: 6: 4: 3: 2: 7627: 7616: 7613: 7611: 7608: 7606: 7603: 7601: 7598: 7597: 7595: 7580: 7577: 7575: 7572: 7570: 7567: 7565: 7562: 7560: 7557: 7556: 7554: 7550: 7544: 7541: 7537: 7534: 7532: 7529: 7528: 7527: 7524: 7523: 7521: 7519: 7515: 7505: 7502: 7500: 7497: 7494: 7491: 7489: 7485: 7482: 7481: 7479: 7477: 7476:Lymphocytosis 7473: 7467: 7464: 7463: 7461: 7455: 7445: 7442: 7439: 7435: 7431: 7430: 7426: 7425: 7423: 7419: 7413: 7410: 7408: 7405: 7404: 7402: 7399: 7393: 7389: 7378: 7374: 7373: 7369: 7368: 7366: 7362: 7356: 7353: 7350: 7346: 7343: 7341: 7338: 7336: 7333: 7331: 7330:Hepatosplenic 7328: 7327: 7325: 7323: 7317: 7307: 7304: 7302: 7299: 7297: 7293: 7290: 7289: 7286: 7283: 7281: 7278: 7276: 7272: 7269: 7268: 7266: 7262: 7256: 7253: 7252: 7251: 7250: 7247: 7241: 7238: 7236: 7233: 7231: 7228: 7225: 7224: 7222: 7220: 7216: 7213: 7211: 7207: 7200: 7197: 7195: 7191: 7190: 7186: 7185: 7181: 7177: 7176: 7175:prolymphocyte 7172: 7171: 7168: 7164: 7160: 7157: 7155: 7147: 7144: 7139: 7136: 7134: 7131: 7130: 7129: 7123: 7118: 7113: 7109: 7106: 7104: 7100: 7090: 7087: 7085: 7084:Plasmacytosis 7082: 7080: 7077: 7075: 7072: 7070: 7067: 7065: 7062: 7060: 7057: 7056: 7054: 7052: 7048: 7041: 7040:MALT lymphoma 7037: 7036: 7032: 7029: 7025: 7024: 7020: 7016: 7013: 7012: 7011: 7010: 7006: 7002: 6999: 6997: 6994: 6992: 6989: 6987: 6984: 6983: 6982: 6981: 6977: 6974: 6970: 6969: 6965: 6964: 6962: 6958: 6948: 6947: 6942: 6941: 6939: 6936: 6932: 6927: 6923: 6919: 6912: 6908: 6907: 6903: 6900: 6896: 6893: 6892: 6890: 6887: 6883: 6879: 6875: 6868: 6865: 6863: 6860: 6858: 6855: 6853: 6849: 6848: 6844: 6843:marginal zone 6840: 6839: 6835: 6832: 6830: 6827: 6825: 6822: 6820: 6816: 6815: 6811: 6807: 6806: 6804: 6801: 6797: 6790: 6786: 6785: 6781: 6779: 6776: 6775: 6773: 6770: 6766: 6759: 6755: 6754: 6750: 6747: 6743: 6742: 6738: 6737: 6735: 6732: 6728: 6722: 6718: 6715: 6713: 6711: 6707: 6704: 6696: 6693: 6688: 6685: 6684: 6683: 6677: 6672: 6667: 6663: 6659: 6654: 6650: 6643: 6638: 6636: 6631: 6629: 6624: 6623: 6620: 6607: 6603: 6602: 6598: 6596: 6592: 6591: 6587: 6585: 6581: 6580: 6576: 6575: 6572: 6568: 6561: 6557: 6556: 6552: 6550: 6546: 6545: 6541: 6539: 6535: 6534: 6530: 6527: 6526: 6522: 6520: 6516: 6515: 6511: 6507: 6505: 6501: 6500: 6496: 6492: 6490: 6486: 6485: 6481: 6477: 6476: 6473: 6468: 6464: 6458: 6454: 6451: 6449: 6445: 6442: 6440: 6436: 6430: 6426: 6425: 6421: 6416: 6415: 6404: 6400: 6396: 6390: 6386: 6382: 6377: 6376: 6357: 6353: 6346: 6331: 6327: 6320: 6306:on 2016-03-17 6305: 6301: 6297: 6291: 6275: 6271: 6265: 6257: 6253: 6246: 6230: 6224: 6209: 6205: 6198: 6187:September 18, 6182: 6178: 6171: 6156: 6152: 6146: 6130: 6126: 6120: 6104: 6098: 6090: 6084: 6069: 6068: 6063: 6056: 6050: 6045: 6037: 6033: 6029: 6023: 6007: 6003: 5996: 5980: 5976: 5970: 5955: 5951: 5944: 5942: 5926: 5922: 5916: 5902:on 2015-12-22 5901: 5897: 5891: 5875: 5871: 5867: 5861: 5847:on 2015-02-04 5846: 5842: 5838: 5832: 5817: 5813: 5809: 5802: 5795: 5794:80-902731-7-3 5791: 5787: 5781: 5768: 5767: 5759: 5744: 5743: 5738: 5731: 5724:. 2003-07-14. 5723: 5722: 5717: 5711: 5695: 5694: 5689: 5682: 5666: 5665: 5660: 5653: 5638: 5632: 5624: 5620: 5614: 5608: 5603: 5589:on 2016-08-18 5588: 5584: 5578: 5564:on 2016-09-12 5563: 5559: 5553: 5537: 5533: 5527: 5519: 5511: 5507: 5503: 5502: 5497: 5490: 5482: 5478: 5472: 5468: 5467: 5459: 5444: 5438: 5434: 5433: 5425: 5409: 5403: 5387: 5381: 5365: 5359: 5351: 5347: 5341: 5326: 5320: 5312: 5308: 5303: 5298: 5294: 5290: 5286: 5279: 5277: 5275: 5273: 5271: 5262: 5258: 5254: 5250: 5247:(6): 386–93. 5246: 5242: 5235: 5227: 5221: 5217: 5210: 5208: 5206: 5204: 5202: 5200: 5184: 5180: 5174: 5172: 5155: 5151: 5147: 5141: 5127:on 2018-01-25 5126: 5122: 5121:www.cancer.ca 5118: 5112: 5104: 5100: 5095: 5090: 5086: 5082: 5078: 5074: 5070: 5063: 5055: 5051: 5046: 5041: 5037: 5033: 5029: 5025: 5021: 5014: 5012: 5010: 4993: 4989: 4985: 4979: 4971: 4965: 4961: 4957: 4950: 4934: 4930: 4926: 4920: 4912: 4908: 4904: 4900: 4895: 4890: 4887:(5): 683–90. 4886: 4882: 4878: 4871: 4869: 4860: 4856: 4851: 4846: 4842: 4838: 4834: 4830: 4826: 4819: 4811: 4807: 4802: 4797: 4792: 4787: 4783: 4779: 4775: 4768: 4760: 4756: 4751: 4746: 4742: 4738: 4734: 4727: 4719: 4715: 4711: 4707: 4702: 4697: 4693: 4689: 4685: 4677: 4669: 4665: 4660: 4655: 4651: 4647: 4643: 4639: 4635: 4628: 4620: 4616: 4611: 4606: 4602: 4598: 4594: 4590: 4586: 4579: 4571: 4567: 4562: 4557: 4553: 4549: 4545: 4541: 4537: 4530: 4522: 4518: 4514: 4510: 4506: 4498: 4490: 4486: 4481: 4476: 4472: 4468: 4464: 4457: 4449: 4445: 4440: 4435: 4431: 4427: 4423: 4419: 4415: 4408: 4394:on 2012-09-09 4393: 4389: 4383: 4375: 4371: 4367: 4363: 4360:(4): 854–62. 4359: 4355: 4347: 4339: 4335: 4331: 4327: 4323: 4319: 4315: 4308: 4300: 4296: 4291: 4286: 4282: 4278: 4274: 4270: 4266: 4259: 4251: 4247: 4242: 4237: 4233: 4229: 4225: 4221: 4217: 4210: 4202: 4198: 4194: 4190: 4185: 4180: 4176: 4172: 4168: 4161: 4153: 4149: 4145: 4141: 4136: 4131: 4127: 4123: 4119: 4112: 4104: 4100: 4096: 4092: 4088: 4084: 4077: 4069: 4065: 4061: 4057: 4053: 4049: 4042: 4034: 4030: 4026: 4022: 4017: 4012: 4008: 4004: 4000: 3993: 3985: 3981: 3977: 3973: 3970:(5): 385–90. 3969: 3965: 3958: 3944:on 2011-08-17 3943: 3939: 3933: 3925: 3921: 3916: 3911: 3907: 3903: 3899: 3892: 3884: 3880: 3876: 3872: 3867: 3862: 3858: 3854: 3850: 3843: 3835: 3831: 3826: 3821: 3816: 3811: 3807: 3803: 3799: 3792: 3784: 3780: 3775: 3770: 3766: 3762: 3758: 3754: 3750: 3743: 3735: 3731: 3726: 3721: 3717: 3713: 3709: 3705: 3701: 3693: 3691: 3674: 3670: 3664: 3662: 3648: 3644: 3640: 3636: 3629: 3621: 3617: 3612: 3607: 3603: 3599: 3595: 3591: 3587: 3579: 3571: 3567: 3562: 3557: 3554:(12): 591–7. 3553: 3549: 3545: 3538: 3530: 3529: 3521: 3508: 3504: 3500: 3496: 3489: 3481: 3477: 3470: 3462: 3458: 3454: 3450: 3445: 3440: 3436: 3432: 3428: 3421: 3413: 3409: 3404: 3399: 3395: 3391: 3387: 3380: 3372: 3368: 3363: 3358: 3354: 3350: 3346: 3339: 3331: 3327: 3323: 3319: 3314: 3309: 3305: 3301: 3297: 3290: 3282: 3278: 3273: 3268: 3264: 3260: 3256: 3249: 3241: 3237: 3232: 3227: 3223: 3219: 3215: 3208: 3192: 3188: 3182: 3180: 3171: 3167: 3163: 3159: 3154: 3149: 3145: 3141: 3137: 3130: 3122: 3118: 3114: 3110: 3106: 3102: 3098: 3094: 3090: 3083: 3075: 3071: 3067: 3063: 3058: 3053: 3049: 3045: 3041: 3034: 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2217: 2211: 2209: 2207: 2205: 2203: 2186: 2182: 2178: 2172: 2170: 2168: 2159: 2153: 2149: 2143: 2141: 2139: 2122: 2118: 2114: 2108: 2106: 2104: 2102: 2100: 2098: 2096: 2094: 2092: 2083: 2079: 2075: 2071: 2066: 2061: 2057: 2053: 2048: 2043: 2039: 2035: 2031: 2027: 2023: 2016: 2014: 2009: 1998: 1995: 1992: 1989: 1988: 1983: 1980: 1977: 1973: 1970: 1967: 1964: 1961: 1960:Arlen Specter 1958: 1955: 1951: 1947: 1943: 1942:Flip Saunders 1940: 1937: 1934: 1931: 1927: 1923: 1920: 1917: 1913: 1909: 1908:first baseman 1905: 1904:Anthony Rizzo 1902: 1899: 1895: 1892: 1889: 1885: 1884:Laura Packard 1882: 1879: 1878:Nanni Moretti 1876: 1873: 1870: 1867: 1866:Jack Lisowski 1864: 1861: 1857: 1854: 1851: 1847: 1846:Mario Lemieux 1844: 1841: 1840: 1835: 1831: 1828: 1825: 1822: 1819: 1816: 1812: 1808: 1805: 1802: 1801: 1796: 1795:Dexter Morgan 1792: 1789: 1786: 1783: 1780: 1776: 1772: 1768: 1764: 1761: 1758: 1757:Delta Goodrem 1755: 1752: 1748: 1745: 1742: 1739: 1736: 1733: 1730: 1727: 1724: 1720: 1716: 1713: 1710: 1706: 1703: 1700: 1696: 1695:Howard Carter 1693: 1690: 1686: 1685:Dale Carnegie 1683: 1680: 1676: 1673: 1670: 1666: 1662: 1661:strong safety 1658: 1655: 1652: 1649: 1648: 1645:Notable cases 1642: 1640: 1636: 1631: 1629: 1625: 1621: 1617: 1612: 1610: 1606: 1602: 1598: 1595: 1590: 1588: 1584: 1579: 1577: 1573: 1570:, one was of 1569: 1565: 1561: 1557: 1548: 1539: 1533:United States 1530: 1522: 1513: 1511: 1507: 1502: 1498: 1495: 1490: 1486: 1482: 1467: 18–19.8 1461: 16.2–18 1425: 5.4–7.2 1419: 3.6–5.4 1413: 1.8–3.6 1401: no data 1394: 1390: 1386: 1382: 1373: 1369: 1365: 1363: 1359: 1350: 1347: 1345:< 4.0 g/dl 1344: 1341: 1339: 1336: 1333: 1330: 1327: 1324: 1321: 1318: 1317: 1316: 1313: 1309: 1307: 1296: 1287: 1284: 1282: 1278: 1273: 1270: 1266: 1255: 1253: 1247: 1245: 1240: 1236: 1232: 1230: 1221: 1218: 1216: 1213: 1211: 1209: 1208: 1205: 1202: 1200: 1197: 1195: 1193: 1192: 1189: 1185: 1182: 1180: 1177: 1175: 1172: 1170: 1167: 1166: 1163: 1160: 1158: 1154: 1151: 1149: 1146: 1144: 1141: 1140: 1137: 1134: 1132: 1129: 1127: 1124: 1122: 1119: 1118: 1115: 1112: 1110: 1107: 1105: 1102: 1100: 1097: 1096: 1092: 1087: 1084: 1080: 1076: 1073: 1069: 1065: 1061: 1057: 1054: 1053: 1048: 1046: 1042: 1038: 1034: 1030: 1026: 1025: 1020: 1019: 1016: 1013: 1011: 1008: 1006: 1003: 1001: 998: 997: 994: 992: 988: 983: 978: 970: 968: 960: 957: 954: 951: 948: 947: 946: 943: 941: 935: 933: 929: 925: 921: 914: 913:H&E stain 910: 906: 902: 895: 891: 882: 881:may be seen. 880: 875: 873: 850: 845: 838: 833: 826: 821: 814: 809: 808: 807: 800: 797: 793: 790: 786: 783: 782: 781: 779: 774: 772: 768: 764: 760: 756: 752: 749:radiographs, 748: 744: 740: 739: 733: 725: 723: 719: 715: 706: 704: 699: 697: 693: 689: 685: 681: 672: 665: 660: 652: 649: 647: 644: 642: 639: 638: 635: 632: 630: 627: 624: 620: 616: 613: 612: 609: 606: 604: 601: 598: 594: 591: 588: 587: 583: 580: 578: 575: 572: 567: 564: 563: 560: 557: 555: 552: 549: 545: 541: 537: 533: 530: 526: 524: 521: 520: 517: 514: 512: 509: 506: 503: 502: 499: 496: 493: 489: 485: 481: 477: 467: 458: 456: 452: 448: 444: 431: 428: 424: 421: 418: 414: 411: 408: 404: 403:pathognomonic 400: 396: 391: 388: 385: 382: 378: 375: 372: 368: 365: 360: 356: 353: 350: 347: 343: 340: 336: 334: 331: 329: 326: 325: 323: 320: 316: 312: 308: 304: 301: 300: 299: 291: 287: 285: 284:heart disease 281: 277: 273: 269: 264: 262: 258: 254: 250: 245: 243: 239: 235: 231: 227: 223: 219: 215: 211: 207: 203: 199: 195: 187: 184: 182: 178: 175:23,900 (2015) 174: 170: 166: 162: 158: 155: 153: 149: 146: 145:immunotherapy 142: 138: 134: 131: 127: 124: 121: 119: 115: 112: 108: 105: 103: 99: 96: 93:, nonpainful 92: 88: 84: 81: 79: 75: 72: 68: 65: 63: 59: 55: 51: 47: 43: 38: 34: 30: 25: 19: 7610:Rare cancers 7427: 7370: 7364:By infection 7245: 7244: 7226: 7187: 7173: 7151:development/ 7079:Plasmacytoma 7033: 7021: 7007: 6995: 6978: 6966: 6960:By infection 6943: 6904: 6894: 6841: 6808: 6782: 6751: 6741:naive B cell 6739: 6700:development/ 6599: 6588: 6577: 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Retrieved 3672: 3650:, retrieved 3638: 3628: 3593: 3589: 3578: 3551: 3547: 3537: 3527: 3520: 3510:, retrieved 3498: 3488: 3479: 3469: 3434: 3430: 3420: 3393: 3389: 3379: 3352: 3348: 3338: 3303: 3299: 3289: 3262: 3258: 3248: 3221: 3217: 3207: 3195:. Retrieved 3191:the original 3143: 3139: 3129: 3096: 3092: 3082: 3047: 3043: 3033: 3006: 2971:(1): 32–43. 2968: 2964: 2954: 2919: 2915: 2905: 2894:. Retrieved 2890: 2881: 2846: 2842: 2832: 2807: 2803: 2797: 2778: 2772: 2760:. Retrieved 2756: 2725: 2677:(6): 874–5. 2674: 2670: 2660: 2648:. Retrieved 2639: 2589: 2585: 2539: 2535: 2525: 2492: 2488: 2482: 2449: 2445: 2439: 2430: 2426: 2392: 2388: 2353: 2346: 2311: 2307: 2258: 2254: 2228:. Retrieved 2219: 2189:. Retrieved 2180: 2147: 2125:. Retrieved 2116: 2029: 2025: 1986: 1922:Dave Roberts 1856:Dinu Lipatti 1837: 1798: 1767:Vlogbrothers 1741:Gerald Finzi 1719:running back 1715:James Conner 1675:David Brooks 1632: 1624:tuberculosis 1613: 1609:Dorothy Reed 1599: 1594:Samuel Wilks 1591: 1586: 1580: 1553: 1536: 1528: 1519: 1503: 1499: 1479:Unlike some 1478: 1437: 9–10.8 1376:Epidemiology 1370: 1366: 1354: 1314: 1310: 1302: 1293: 1285: 1274: 1269:solid tumors 1261: 1248: 1241: 1237: 1233: 1226: 1188:Procarbazine 1179:Chlormethine 1169:Procarbazine 1099:Chlormethine 1050: 1044: 1041:Procarbazine 1022: 979: 976: 964: 944: 936: 917: 876: 868: 804: 775: 769:or surgical 763:gallium scan 736: 734: 731: 712: 700: 677: 547: 544:plasma cells 531: 490:seen in the 473: 464: 455:gallium scan 440: 377:Hepatomegaly 367:Splenomegaly 337:Unexplained 333:Night sweats 297: 288: 268:chemotherapy 265: 246: 230:night sweats 197: 193: 192: 133:Chemotherapy 102:Risk factors 87:night sweats 18: 7246:aggressive: 7219:MF+variants 6758:Mantle cell 6753:mantle zone 6579:MedlinePlus 6073:6 September 5642:27 November 5183:www.cdc.gov 4275:: iii70–5. 3482:. NBK65726. 3197:February 1, 2810:(1): 66–7. 1832:, American 1824:Tessa James 1699:Tutankhamun 1431: 7.2–9 1387:death from 1362:mediastinum 1351:≥ 15,000/μL 1174:Dacarbazine 1162:Vincristine 1157:Vincristine 1153:Vinblastine 1148:Vinblastine 1114:Doxorubicin 1109:Doxorubicin 1104:Doxorubicin 1072:dacarbazine 1068:vinblastine 662:Lymph node 640:Unspecified 540:eosinophils 536:lymphocytes 507:Description 447:Blood tests 395:sensitivity 354:(lassitude) 339:weight loss 307:lymph nodes 234:weight loss 214:lymphocytes 181:Named after 91:weight loss 54:Field stain 32:Other names 7594:Categories 7322:peripheral 6819:Follicular 6649:Leukaemias 6601:Patient UK 6544:DiseasesDB 6361:2024-01-18 6310:2016-03-26 6280:30 October 6214:2015-10-25 6161:2020-10-28 5906:2015-12-16 5851:2015-03-04 5822:2015-03-04 5772:2023-08-26 5593:2016-07-22 5568:2016-09-29 5520:required.) 5448:8 February 5414:8 February 5392:6 February 5370:13 October 5331:2017-12-23 5189:2019-11-25 5160:27 October 5131:2018-02-08 4398:2012-08-26 4122:The Lancet 3948:2012-08-26 3652:2022-11-09 3639:StatPearls 3512:2022-11-09 3499:StatPearls 3025:1011064243 2896:2022-11-09 2004:References 1982:Ethan Zohn 1946:head coach 1898:midfielder 1763:Hank Green 1659:, All-Pro 1657:Eric Berry 1651:Paul Allen 1326:Hemoglobin 1220:Prednisone 1215:Prednisone 1143:Prednisone 1079:Stanford V 1077:The newer 1060:Adriamycin 1037:Prednisone 1010:Stanford V 973:Management 945:Variants: 905:Micrograph 894:Micrograph 885:Microscopy 865:Macroscopy 771:laparotomy 590:Lymphocyte 492:lymph node 488:infiltrate 484:morphology 480:pathologic 359:B symptoms 344:Low-grade 328:Itchy skin 67:Hematology 50:Micrograph 7457:Lymphoid+ 7227:indolent: 7210:Cutaneous 7051:Cutaneous 6829:GCB DLBCL 6824:Burkitt's 6653:lymphomas 6590:eMedicine 6555:SNOMED CT 6427:is being 6403:648759629 6235:31 August 6135:30 August 6012:30 August 5766:Remission 5721:Billboard 4998:18 August 2495:: 18–41. 2230:13 August 2191:13 August 2127:12 August 1860:cortisone 1830:Sean Kent 1779:remission 1775:Complexly 1592:In 1856, 1389:lymphomas 1299:Prognosis 1265:leukemias 1229:rituximab 1204:Etoposide 1199:Etoposide 1136:Bleomycin 1131:Bleomycin 1126:Bleomycin 1064:bleomycin 1029:Mustargen 940:chromatin 860:Pathology 789:diaphragm 743:histology 722:rituximab 548:sclerosis 437:Diagnosis 410:Back pain 204:in which 164:Frequency 152:Prognosis 129:Treatment 62:Specialty 7564:leukemia 7122:leukemia 7117:lymphoma 6676:leukemia 6671:lymphoma 6595:med/1022 6560:14537002 6420:template 6208:Archived 6155:ESPN.com 6129:Archived 5985:11 April 5979:Archived 5880:June 18, 5874:Archived 5816:Archived 5700:23 April 5671:23 April 5623:Archived 5542:June 18, 5481:Archived 5350:Archived 5261:10594291 5154:Archived 5103:16917006 5054:25045456 4992:Archived 4933:Archived 4931:. 2009. 4903:23516309 4859:28083035 4810:27900988 4718:11153555 4710:17989384 4668:30702150 4619:30697701 4570:26576687 4521:22592695 4489:21896559 4448:23812271 4374:23790512 4338:23515511 4299:25185243 4250:23023715 4201:43857382 4193:24953862 4152:15815020 4144:22835602 4103:Archived 4099:17715698 4087:Oncology 4068:29994901 4033:16108474 4025:12586628 3984:21183282 3924:19759185 3883:24367707 3875:16172458 3834:23696962 3783:28447341 3734:31930780 3647:31194473 3620:31816062 3570:25418190 3507:32644754 3461:11505564 3453:19759113 3412:26541251 3371:18684866 3330:22493125 3322:16056244 3281:16385563 3240:12078890 3162:15086409 3121:27274760 3113:22867814 3066:15728122 2987:26538004 2946:32345712 2873:20200355 2716:Archived 2713:Page 242 2650:June 18, 2644:Archived 2608:26541251 2558:24488779 2517:47010934 2509:29885408 2474:46790198 2466:29316828 2433:: 69–97. 2409:20818856 2369:Archived 2338:27733281 2285:27733282 2224:Archived 2185:Archived 2121:Archived 2074:23245604 2065:10790329 2056:23245604 1987:Survivor 1976:FC Porto 1936:Chip Roy 1910:for the 1663:for the 1628:syphilis 1483:, whose 311:cervical 257:HIV/AIDS 202:lymphoma 159:88% (US) 111:HIV/AIDS 78:Symptoms 71:oncology 7552:General 7459:myeloid 7421:T or NK 7392:NK cell 6746:CLL/SLL 6538:D006689 5742:YouTube 5311:6381744 5302:2609834 5094:1895473 5045:4103499 4939:Nov 11, 4911:9959867 4850:5216291 4801:5146782 4759:9819449 4659:6354325 4610:6353308 4561:4717525 4439:3906736 4241:3534167 3825:3659263 3774:6478261 3725:6984446 3679:25 July 3611:6963251 3561:4308654 3170:2355660 3074:8192701 2937:7509949 2916:Science 2864:2890576 2824:7777006 2762:25 July 2693:6613116 2684:1010854 2329:5388903 2276:5055577 2082:1541253 1948:of the 1667:of the 1542:History 1489:bimodal 1343:Albumin 1121:Oncovin 1086:BEACOPP 1033:Oncovin 1015:BEACOPP 728:Staging 651:M9650/3 634:M9653/3 608:M9651/3 582:M9652/3 559:M9663/3 532:nodules 470:Classic 406:aching. 352:Fatigue 212:called 7396:(most 7372:HTLV-1 7264:Non-MF 7153:marker 7126:(most 7112:T cell 6784:CD11c+ 6702:marker 6680:(most 6666:B cell 6584:000580 6439:Curlie 6433:  6424:Curlie 6401:  6391:  6352:"Home" 6335:23 May 5959:19 May 5930:19 May 5841:People 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Index


Micrograph
Field stain
Specialty
Hematology
oncology
Symptoms
Fever
night sweats
weight loss
enlarged lymph nodes
Risk factors
Epstein–Barr virus
HIV/AIDS
Diagnostic method
Lymph node biopsy
Chemotherapy
radiation therapy
stem-cell transplant
immunotherapy
Prognosis
Five-year survival rate
Named after
Thomas Hodgkin
lymphoma
cancer
white blood cell
lymphocytes
Reed–Sternberg cells
Thomas Hodgkin

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