48:
484:
It appears that these and other viruses have learned to exploit some defect in the region surrounding A11 that allows the near complete shut-down of gene expression. Oddly, in Africa A11 is at very low frequencies, and homozygotes are rare, suggesting that other genetic susceptibilities may exist
452:
infection. Examination of the virus itself has led to the discovery of strains that can all but turn off the A11-mediated class I response to the virus in A11 enriched peoples (see tables below). This ability to turn off the immune system and for the virus to remain active is a factor in
471:
down-regulation in
Burkitt's lymphoma was subsequently discovered, More recent studies show A11 is down-regulated, and that other genetic defects are a likely cause. The ability to present EB virus antigens revealed a defect in the process after antigen process but before
435:
A11 is also part of a haplotype A11-Cw4-B35-DR1-DQ1 that is a second factor in the rapid progression of HIV. The involvement of non-Hodgkin's lymphoma primarily as a result of
Epstein-Barr virus reinfection does not appear to be a cause in this acceleration.
476:
involvement. Other studies indicated that peptides bind A11 in delivery to the cell surface for CTL screening, but fall off, and are destroyed intracellularly. However, A3 and A11 can process and load antigens even when
431:
There is a strong association between anti-depressant induced hepatitis and HLA-A11. In autoimmune hepatitis, A11 has a synergistic effect, acting together with DR4 and DR3 to increase the odds of disease to over 300.
399:
Serotyping of A11 demonstrates better recognition of the *1101 gene products and poorer recognition of other A*11 gene products. There are ~40 recognized alleles of A*11. There is only one null classified as A11.
2165:
Marcos Y, Fainboim HA, Capucchio M, et al. (June 1994). "Two-locus involvement in the association of human leukocyte antigen with the extrahepatic manifestations of autoimmune chronic active hepatitis".
2432:"Recognition of the Epstein-Barr virus-encoded nuclear antigens EBNA-4 and EBNA-6 by HLA-A11-restricted cytotoxic T lymphocytes: implications for down-regulation of HLA-A11 in Burkitt lymphoma"
2567:"Natural variants of the immunodominant HLA A11-restricted CTL epitope of the EBV nuclear antigen-4 are nonimmunogenic due to intracellular dissociation from MHC class I:peptide complexes"
1820:"T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues"
1783:
Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin".
2130:
Berson A, Fréneaux E, Larrey D, et al. (March 1994). "Possible role of HLA in hepatotoxicity. An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis".
297: "A" serotype group. The serotype is determined by the antibody recognition of α subset of HLA-A α-chains. For A11, the alpha "A" chain are encoded by the HLA-A
1885:
Gregoriadis S, Zervas J, Varletzidis E, Toubis M, Pantazopoulos P, Fessas P (December 1982). "HLA antigens and otosclerosis. A possible new genetic factor".
425:
2481:
Imreh MP, Zhang QJ, de Campos-Lima PO, et al. (July 1995). "Mechanisms of allele-selective down-regulation of HLA class I in
Burkitt's lymphoma".
481:
activity is diminished suggesting an alternative mechanism for loading which may benefit in recovery from some disease but impair recovery of others.
424:. These and other studies suggest an involvement between A11 and secondary effects of certain herpes virus infections. A11 was also found increase in
2350:"Identification and characterization of an Epstein-Barr virus-specific T-cell response in the pathologic tissue of a patient with Hodgkin's disease"
2642:"Risk association between human leukocyte antigen-A allele and high-risk human papillomavirus infection for cervical neoplasia in Chinese women"
20:
2542:
2525:
459:
and recent studies have shown a complex involvement of
Epstein-Barr virus infection as a consequence of low A11 control over infection.
2068:
Konieczna A, Turowski G (1993). "HLA-ABC antigens in supraglottic cancer patients and their relationship with incidence and survival".
2699:
2603:
Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net".
2381:"Down-regulation of class I HLA antigens and of the Epstein-Barr virus-encoded latent membrane protein in Burkitt lymphoma lines"
2252:"Epstein-Barr virus (EBV) nuclear antigen (EBNA)-4 mutation in EBV-associated malignancies in three different populations"
2095:
Barona P, SierrasesĂşmaga L, AntillĂłn F, Villa-ElĂzaga I (1993). "Study of HLA antigens in patients with osteosarcoma".
1873:
275:
2025:
Iannetti P, Morellini M, Raucci U, Cappellacci S (1988). "HLA antigens, epilepsy and cytomegalovirus infection".
467:
eventually lead to the discovery of the virus, however this disease is more evident in Africa. An involvement in
2349:
2692:
312:
are almost synonymous in meaning. A11 is more common in East Asia than elsewhere, it is part of several long
1955:
Xu XP, Li SB, Wang CY, Li QH (June 1986). "Study on the association of HLA with pulmonary tuberculosis".
445:
2526:"Defective presentation of MHC class I-restricted cytotoxic T-cell epitopes in Burkitt's lymphoma cells"
1990:
Kim SJ, Choi IH, Dahlberg S, Nisperos B, Kim JD, Hansen JA (March 1987). "HLA and leprosy in
Koreans".
2605:
2566:
2685:
2202:
468:
287:
1920:
Singhal SK, Mann SB, Datta U, Panda NK, Gupta AK (1999). "Genetic correlation in otosclerosis".
2876:
449:
256:
242:
198:
160:
78:
1869:
463:
455:
271:
302:
111:
89:
8:
1898:
2506:
2276:
2251:
2232:
2050:
2003:
1844:
1819:
1796:
2407:
2380:
2325:
2300:
2267:
2143:
2038:
1933:
2663:
2622:
2618:
2578:
2547:
2498:
2463:
2458:
2431:
2412:
2379:
Masucci MG, Torsteindottir S, Colombani J, Brautbar C, Klein E, Klein G (July 1987).
2361:
2330:
2281:
2224:
2183:
2179:
2147:
2112:
2077:
2042:
2007:
1972:
1937:
1902:
1849:
1800:
2510:
2430:
Gavioli R, De Campos-Lima PO, Kurilla MG, Kieff E, Klein G, Masucci MG (July 1992).
2653:
2614:
2537:
2490:
2453:
2443:
2402:
2392:
2320:
2312:
2271:
2263:
2236:
2214:
2175:
2139:
2104:
2054:
2034:
1999:
1964:
1929:
1894:
1839:
1831:
1792:
1721:
1633:
1569:
1329:
453:
carcinogenesis. Early studies of A serotypes revealed and association of A11 with
2524:
Frisan T, Zhang QJ, Levitskaya J, Coram M, Kurilla MG, Masucci MG (October 1996).
2301:"Analysis of HL-A antigens in patients with Hodgkin's disease and their families"
1737:
417:
102:
1741:
2640:
Chan D, Cheung T, Tam A, Cheung J, Yim S, Lo K, Siu N, Zhou D, Chan P (2005).
1968:
2870:
2565:
Levitsky V, Zhang QJ, Levitskaya J, Kurilla MG, Masucci MG (December 1997).
2448:
2397:
2219:
1866:
2667:
2626:
2543:
10.1002/(SICI)1097-0215(19961009)68:2<251::AID-IJC19>3.0.CO;2-D
2494:
2285:
1941:
1835:
409:
2582:
2551:
2502:
2467:
2416:
2365:
2334:
2228:
2187:
2151:
2116:
2081:
2046:
2011:
1976:
1906:
1853:
2094:
95:
34:
1804:
323:
478:
2378:
2316:
2108:
305:
185:
179:
173:
167:
54:
1652:
1588:
1348:
502:
313:
2711:
2658:
2641:
1818:
de Campos-Lima PO, Levitsky V, Brooks J, et al. (April 1994).
428:
with poor 3 year survival. In osteosarcoma A11 was found elevated.
421:
290:
52:
Rendering of A11 (A*1101-B2M) in complex with HBV peptide homologue
2677:
2024:
1884:
316:
that appear to have been frequent in the ancient peoples of Asia.
2855:
2850:
2843:
2838:
2833:
2826:
2821:
2816:
2811:
2806:
2801:
2796:
2784:
2779:
2774:
2769:
2764:
2759:
2752:
2747:
2429:
413:
73:
1782:
2742:
2737:
2732:
2727:
2602:
82:
2564:
2722:
2708:
294:
107:
38:
2348:
Dolcetti R, Frisan T, Sjöberg J, et al. (August 1995).
1817:
473:
2523:
47:
2250:
Chu PG, Chang KL, Chen WG, et al. (September 1999).
408:
Associations have been observed between A11 and familial
308:. This group currently is dominated by A*1101. A11 and A
2480:
2164:
1989:
2203:"Influence of host genes on HIV-1 disease progression"
2347:
1919:
2129:
2639:
2067:
2868:
485:that steer the virus toward Burkitt's lymphoma.
2598:
2596:
2594:
2592:
325:A11 recognition of some HLA A*11 gene products
2693:
1736:A*1104 is associated with increased risk for
439:
2589:
2298:
2249:
2243:
301:allele group and the β-chain are encoded by
62:-microglobulin (Rose), HBV peptide (yellow).
2558:
2517:
2474:
2423:
2372:
2341:
2292:
2194:
2158:
2123:
2088:
1913:
2700:
2686:
2061:
2018:
1983:
1954:
1948:
1878:
1811:
1759:A11-Cw9-B13 (Southern China & SE Asia)
46:
2657:
2541:
2457:
2447:
2406:
2396:
2324:
2275:
2218:
1843:
1776:
444:There are at least a couple of forms of
403:
2200:
1731:
58: HLA-A11 'alpha chain' (Cyan), β
2869:
2681:
448:that appear to arise from unresolved
1899:10.1001/archotol.1982.00790600013004
2707:
1747:
13:
2004:10.1111/j.1399-0039.1987.tb01567.x
1797:10.1111/j.1399-0039.1978.tb01233.x
14:
2888:
2299:Forbes JF, Morris PJ (May 1972).
1874:European Bioinformatics Institute
2619:10.1034/j.1399-0039.2003.00062.x
16:Human leukocyte antigen serotype
2633:
1860:
1:
2268:10.1016/S0002-9440(10)65193-0
2144:10.1016/S0168-8278(94)80004-9
2039:10.1016/s0387-7604(88)80008-1
1934:10.1016/S0196-0709(99)90019-4
1769:
2436:Proc. Natl. Acad. Sci. U.S.A
2385:Proc. Natl. Acad. Sci. U.S.A
2180:10.1016/0270-9139(94)90230-5
446:lymphoproliferative diseases
7:
319:
10:
2893:
1765:A11-CBL-B13 Northern China
1708:China Beijing Shijiazhuan…
1700:Israel Ashkenazi and Non …
1620:China Beijing Shijiazhuan…
1492:China Beijing Shijiazhuan…
1316:Morocco Berber Nador Meta…
1228:Spain Basque Gipuzkoa Pro…
948:Sri Lanka Colombo Sinhale…
892:India Andhra Pradesh Goll…
820:Singapore Javanese Indone…
796:Spain Basque Arratia Vall…
732:Australia Indig. Cape Yor…
716:China, Shandong, Linqu Co…
676:Australia Indig. Groote E…
652:Taiwanese of Middle China…
488:
440:Epstein–Barr virus anomaly
412:, pulmonary tuberculosis,
18:
2718:
1969:10.3109/08820138609052951
1719:
1715:
1707:
1699:
1691:
1683:
1675:
1667:
1663:
1648:
1631:
1627:
1619:
1611:
1603:
1599:
1584:
1567:
1563:
1555:
1547:
1539:
1531:
1523:
1515:
1507:
1499:
1491:
1483:
1475:
1467:
1459:
1451:
1443:
1435:
1428:Ch. Guangdong Meizhou Han
1427:
1419:
1411:
1403:
1395:
1387:
1379:
1371:
1363:
1359:
1344:
1327:
1323:
1315:
1307:
1299:
1291:
1283:
1275:
1267:
1259:
1251:
1243:
1235:
1227:
1219:
1211:
1203:
1196:Georgia Tbilisi Georgian…
1195:
1187:
1179:
1171:
1163:
1156:Australia New South Wales
1155:
1147:
1139:
1131:
1123:
1115:
1107:
1099:
1092:Australia Indig. Yuendumu
1091:
1083:
1075:
1067:
1059:
1051:
1043:
1035:
1027:
1019:
1011:
1003:
995:
987:
979:
972:Australia Indig. Kimberly
971:
963:
955:
947:
939:
931:
923:
915:
907:
899:
891:
883:
875:
867:
859:
851:
843:
835:
827:
819:
811:
803:
795:
787:
779:
771:
763:
755:
747:
739:
731:
723:
715:
707:
699:
691:
683:
675:
667:
659:
651:
643:
635:
627:
619:
611:
603:
595:
587:
579:
571:
563:
555:
547:
536:
517:
513:
498:
269:
251:
237:
232:Available structures
220:
216:
211:
193:
155:
150:Available structures
138:
134:
129:
121:
101:
88:
72:
67:
45:
32:
27:
940:Mongolia Khoton Tarialan
2449:10.1073/pnas.89.13.5862
2398:10.1073/pnas.84.13.4567
2220:10.1096/fasebj.12.9.625
1524:India West Coast Parsis
469:cytotoxic T-lymphocytes
288:human leukocyte antigen
21:HLA serotypes explained
2495:10.1002/ijc.2910620117
1836:10.1084/jem.179.4.1297
1644:HLA A*1104 frequencies
1580:HLA A*1103 frequencies
1340:HLA A*1102 frequencies
1140:USA Caucasian Bethesda
1020:Spain North Cantabrian
996:Spain North Cabuernigo
884:China Harbin N. Korean
660:PNG New Britain Rabaul
494:HLA A*1101 frequencies
79:transmembrane receptor
2201:Roger M (June 1998).
1740:resulting from human
1668:Georgia Svaneti Svans
956:Georgia Tbilisi Kurds
876:India Mumbai Marathas
844:Georgia Svaneti Svans
812:Russia Murmansk Saomi
404:In infectious disease
41:cell surface antigen)
19:Further information:
1732:Disease associations
1676:Singapore Riau Malay
1516:China Inner Mongolia
1404:China Guangxi Maonan
868:China Yunnan Han (2)
780:China Inner Mongolia
748:Singapore Riau Malay
580:China Guangxi Maonan
540:West Schrader Ranges
270:Alleles link-out to
1645:
1581:
1341:
1252:Portugal South pop2
1148:Portugal Centre (2)
740:PNG Karimui Plateau
495:
426:supraglottic cancer
326:
1738:cervical neoplasia
1722:Allele frequencies
1692:India North Hindus
1643:
1634:Allele frequencies
1579:
1570:Allele frequencies
1420:Philippines Ivatan
1339:
1330:Allele frequencies
1172:USA Hawaii Okinawa
1132:Philippines Ivatan
1108:USA Caucasians (3)
1084:Italy Sardinia (3)
852:India North Hindus
636:Thailand Northeast
493:
464:Burkitt's lymphoma
456:Hodgkin's lymphoma
450:Epstein–Barr virus
324:
2864:
2863:
2317:10.1172/JCI106908
2109:10.1159/000154149
1867:Allele Query Form
1729:
1728:
1725:
1659:
1641:
1640:
1637:
1604:China Yunnan Lisu
1595:
1577:
1576:
1573:
1548:China Yunnan Lisu
1540:China Qinghai Hui
1500:Italy North pop 1
1468:Singapore Chinese
1452:Taiwan Minnan (1)
1444:Hong Kong Chinese
1355:
1337:
1336:
1333:
1268:Italy North Pavia
1260:England Newcastle
980:India North Delhi
916:Israel Arab Druse
804:China Qinghai Hui
644:Singapore Chinese
596:Taiwan Minnan (1)
509:
397:
396:
281:
280:
265:
264:
207:
206:
2884:
2702:
2695:
2688:
2679:
2678:
2672:
2671:
2661:
2637:
2631:
2630:
2600:
2587:
2586:
2562:
2556:
2555:
2545:
2521:
2515:
2514:
2478:
2472:
2471:
2461:
2451:
2427:
2421:
2420:
2410:
2400:
2376:
2370:
2369:
2345:
2339:
2338:
2328:
2296:
2290:
2289:
2279:
2247:
2241:
2240:
2222:
2198:
2192:
2191:
2162:
2156:
2155:
2127:
2121:
2120:
2092:
2086:
2085:
2065:
2059:
2058:
2022:
2016:
2015:
1987:
1981:
1980:
1952:
1946:
1945:
1922:Am J Otolaryngol
1917:
1911:
1910:
1887:Arch Otolaryngol
1882:
1876:
1864:
1858:
1857:
1847:
1815:
1809:
1808:
1780:
1762:A11-C10-B13 Buyi
1756:A11-Cw2-B13 (Li)
1748:A11-B haplotypes
1720:
1657:
1649:Study population
1646:
1642:
1632:
1593:
1585:Study population
1582:
1578:
1568:
1353:
1345:Study population
1342:
1338:
1328:
1284:Sweden Stockholm
1244:Russia Northwest
1100:Mongolia Tsaatan
1052:Ireland Northern
964:Mongolia Khalkha
860:Pakistan Burusho
564:ChinaYunnan Naxi
507:
499:Study population
496:
492:
327:
311:
300:
259:
245:
218:
217:
201:
188:
182:
176:
170:
163:
136:
135:
57:
50:
25:
24:
2892:
2891:
2887:
2886:
2885:
2883:
2882:
2881:
2867:
2866:
2865:
2860:
2714:
2706:
2676:
2675:
2652:(10): 1749–56.
2638:
2634:
2606:Tissue Antigens
2601:
2590:
2577:(11): 5383–90.
2563:
2559:
2522:
2518:
2479:
2475:
2428:
2424:
2391:(13): 4567–71.
2377:
2373:
2360:(16): 3675–81.
2346:
2342:
2305:J. Clin. Invest
2297:
2293:
2248:
2244:
2199:
2195:
2163:
2159:
2128:
2124:
2093:
2089:
2066:
2062:
2023:
2019:
1992:Tissue Antigens
1988:
1984:
1957:Immunol. Invest
1953:
1949:
1918:
1914:
1883:
1879:
1865:
1861:
1830:(4): 1297–305.
1816:
1812:
1785:Tissue Antigens
1781:
1777:
1772:
1750:
1734:
1724:presented, only
1655:
1636:presented, only
1612:China Yunnan Nu
1591:
1572:presented, only
1351:
1332:presented, only
1076:Italy North (1)
1012:Russia Tuva (2)
924:South Korea (3)
772:Pakistan Pathan
724:Pakistan Sindhi
700:Pakistan Baloch
684:India New Delhi
668:Pakistan Brahui
628:China South Han
588:China Guangzhou
505:
491:
442:
420:infection with
418:cytomegalovirus
406:
322:
309:
298:
255:
241:
233:
228:
223:
197:
184:
178:
172:
166:
159:
151:
146:
141:
115:
63:
61:
53:
23:
17:
12:
11:
5:
2890:
2880:
2879:
2862:
2861:
2859:
2858:
2853:
2848:
2847:
2846:
2841:
2831:
2830:
2829:
2824:
2819:
2814:
2809:
2804:
2794:
2789:
2788:
2787:
2782:
2777:
2772:
2767:
2757:
2756:
2755:
2750:
2740:
2735:
2730:
2725:
2719:
2716:
2715:
2705:
2704:
2697:
2690:
2682:
2674:
2673:
2659:10.1086/497342
2632:
2613:(5): 403–407.
2588:
2557:
2530:Int. J. Cancer
2516:
2483:Int. J. Cancer
2473:
2442:(13): 5862–6.
2422:
2371:
2340:
2311:(5): 1156–63.
2291:
2242:
2193:
2157:
2122:
2087:
2060:
2017:
1982:
1947:
1912:
1893:(12): 769–71.
1877:
1859:
1810:
1774:
1773:
1771:
1768:
1767:
1766:
1763:
1760:
1757:
1749:
1746:
1742:papillomavirus
1733:
1730:
1727:
1726:
1717:
1716:
1713:
1712:
1709:
1705:
1704:
1701:
1697:
1696:
1693:
1689:
1688:
1685:
1684:American Samoa
1681:
1680:
1677:
1673:
1672:
1669:
1665:
1664:
1661:
1660:
1650:
1639:
1638:
1629:
1628:
1625:
1624:
1621:
1617:
1616:
1613:
1609:
1608:
1605:
1601:
1600:
1597:
1596:
1586:
1575:
1574:
1565:
1564:
1561:
1560:
1557:
1553:
1552:
1549:
1545:
1544:
1541:
1537:
1536:
1533:
1529:
1528:
1525:
1521:
1520:
1517:
1513:
1512:
1509:
1505:
1504:
1501:
1497:
1496:
1493:
1489:
1488:
1485:
1481:
1480:
1477:
1473:
1472:
1469:
1465:
1464:
1461:
1457:
1456:
1453:
1449:
1448:
1445:
1441:
1440:
1437:
1433:
1432:
1429:
1425:
1424:
1421:
1417:
1416:
1413:
1409:
1408:
1405:
1401:
1400:
1397:
1393:
1392:
1389:
1385:
1384:
1381:
1377:
1376:
1373:
1369:
1368:
1365:
1364:Taiwan Saisiat
1361:
1360:
1357:
1356:
1346:
1335:
1334:
1325:
1324:
1321:
1320:
1317:
1313:
1312:
1309:
1305:
1304:
1301:
1297:
1296:
1293:
1289:
1288:
1285:
1281:
1280:
1277:
1273:
1272:
1269:
1265:
1264:
1261:
1257:
1256:
1253:
1249:
1248:
1245:
1241:
1240:
1237:
1233:
1232:
1229:
1225:
1224:
1221:
1217:
1216:
1213:
1209:
1208:
1205:
1201:
1200:
1197:
1193:
1192:
1189:
1185:
1184:
1181:
1177:
1176:
1173:
1169:
1168:
1165:
1161:
1160:
1157:
1153:
1152:
1149:
1145:
1144:
1141:
1137:
1136:
1133:
1129:
1128:
1125:
1121:
1120:
1117:
1113:
1112:
1109:
1105:
1104:
1101:
1097:
1096:
1093:
1089:
1088:
1085:
1081:
1080:
1077:
1073:
1072:
1069:
1065:
1064:
1061:
1057:
1056:
1053:
1049:
1048:
1045:
1041:
1040:
1037:
1033:
1032:
1029:
1025:
1024:
1021:
1017:
1016:
1013:
1009:
1008:
1005:
1001:
1000:
997:
993:
992:
989:
985:
984:
981:
977:
976:
973:
969:
968:
965:
961:
960:
957:
953:
952:
949:
945:
944:
941:
937:
936:
933:
929:
928:
925:
921:
920:
917:
913:
912:
909:
905:
904:
901:
900:Taiwan Saisiat
897:
896:
893:
889:
888:
885:
881:
880:
877:
873:
872:
869:
865:
864:
861:
857:
856:
853:
849:
848:
845:
841:
840:
837:
833:
832:
829:
825:
824:
821:
817:
816:
813:
809:
808:
805:
801:
800:
797:
793:
792:
789:
788:American Samoa
785:
784:
781:
777:
776:
773:
769:
768:
765:
761:
760:
757:
753:
752:
749:
745:
744:
741:
737:
736:
733:
729:
728:
725:
721:
720:
717:
713:
712:
709:
705:
704:
701:
697:
696:
693:
689:
688:
685:
681:
680:
677:
673:
672:
669:
665:
664:
661:
657:
656:
653:
649:
648:
645:
641:
640:
637:
633:
632:
629:
625:
624:
621:
617:
616:
613:
609:
608:
605:
601:
600:
597:
593:
592:
589:
585:
584:
581:
577:
576:
573:
569:
568:
565:
561:
560:
557:
553:
552:
549:
545:
544:
541:
534:
533:
530:
515:
514:
511:
510:
500:
490:
487:
441:
438:
405:
402:
395:
394:
391:
388:
384:
383:
380:
377:
373:
372:
369:
366:
362:
361:
358:
355:
351:
350:
347:
344:
340:
339:
336:
331:
321:
318:
279:
278:
267:
266:
263:
262:
260:
253:
249:
248:
246:
239:
235:
234:
231:
229:
226:
224:
221:
214:
213:
209:
208:
205:
204:
202:
195:
191:
190:
164:
157:
153:
152:
149:
147:
144:
142:
139:
132:
131:
127:
126:
123:
119:
118:
116:-microglobulin
113:
105:
99:
98:
92:
86:
85:
76:
70:
69:
65:
64:
59:
51:
43:
42:
30:
29:
15:
9:
6:
4:
3:
2:
2889:
2878:
2877:HLA-A alleles
2875:
2874:
2872:
2857:
2854:
2852:
2849:
2845:
2842:
2840:
2837:
2836:
2835:
2832:
2828:
2825:
2823:
2820:
2818:
2815:
2813:
2810:
2808:
2805:
2803:
2800:
2799:
2798:
2795:
2793:
2790:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2762:
2761:
2758:
2754:
2751:
2749:
2746:
2745:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2720:
2717:
2713:
2710:
2703:
2698:
2696:
2691:
2689:
2684:
2683:
2680:
2669:
2665:
2660:
2655:
2651:
2647:
2643:
2636:
2628:
2624:
2620:
2616:
2612:
2608:
2607:
2599:
2597:
2595:
2593:
2584:
2580:
2576:
2572:
2568:
2561:
2553:
2549:
2544:
2539:
2535:
2531:
2527:
2520:
2512:
2508:
2504:
2500:
2496:
2492:
2488:
2484:
2477:
2469:
2465:
2460:
2455:
2450:
2445:
2441:
2437:
2433:
2426:
2418:
2414:
2409:
2404:
2399:
2394:
2390:
2386:
2382:
2375:
2367:
2363:
2359:
2355:
2351:
2344:
2336:
2332:
2327:
2322:
2318:
2314:
2310:
2306:
2302:
2295:
2287:
2283:
2278:
2273:
2269:
2265:
2261:
2257:
2256:Am. J. Pathol
2253:
2246:
2238:
2234:
2230:
2226:
2221:
2216:
2213:(9): 625–32.
2212:
2208:
2204:
2197:
2189:
2185:
2181:
2177:
2174:(6): 1371–4.
2173:
2169:
2161:
2153:
2149:
2145:
2141:
2138:(3): 336–42.
2137:
2133:
2126:
2118:
2114:
2110:
2106:
2102:
2098:
2091:
2083:
2079:
2075:
2071:
2070:Mater Med Pol
2064:
2056:
2052:
2048:
2044:
2040:
2036:
2032:
2028:
2021:
2013:
2009:
2005:
2001:
1998:(3): 146–53.
1997:
1993:
1986:
1978:
1974:
1970:
1966:
1963:(4): 327–32.
1962:
1958:
1951:
1943:
1939:
1935:
1931:
1927:
1923:
1916:
1908:
1904:
1900:
1896:
1892:
1888:
1881:
1875:
1871:
1868:
1863:
1855:
1851:
1846:
1841:
1837:
1833:
1829:
1825:
1821:
1814:
1806:
1802:
1798:
1794:
1791:(2): 96–112.
1790:
1786:
1779:
1775:
1764:
1761:
1758:
1755:
1754:
1753:
1745:
1743:
1739:
1723:
1718:
1714:
1710:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1674:
1670:
1666:
1662:
1654:
1651:
1647:
1635:
1630:
1626:
1622:
1618:
1614:
1610:
1606:
1602:
1598:
1590:
1587:
1583:
1571:
1566:
1562:
1558:
1554:
1550:
1546:
1542:
1538:
1534:
1530:
1526:
1522:
1518:
1514:
1510:
1508:Taiwan Taroko
1506:
1502:
1498:
1494:
1490:
1486:
1482:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1414:
1412:Taiwan Atayal
1410:
1406:
1402:
1398:
1396:Taiwan Siraya
1394:
1390:
1388:Taiwan Puyuma
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1358:
1350:
1347:
1343:
1331:
1326:
1322:
1318:
1314:
1310:
1308:Italy Bergamo
1306:
1302:
1300:Macedonia (4)
1298:
1294:
1290:
1286:
1282:
1278:
1274:
1270:
1266:
1262:
1258:
1254:
1250:
1246:
1242:
1238:
1234:
1230:
1226:
1222:
1218:
1214:
1210:
1206:
1204:Ireland South
1202:
1198:
1194:
1190:
1186:
1182:
1178:
1174:
1170:
1166:
1162:
1158:
1154:
1150:
1146:
1142:
1138:
1134:
1130:
1126:
1124:Taiwan Taroko
1122:
1118:
1114:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1082:
1078:
1074:
1070:
1066:
1062:
1060:Taiwan Atayal
1058:
1054:
1050:
1046:
1042:
1038:
1034:
1030:
1028:Japan Central
1026:
1022:
1018:
1014:
1010:
1006:
1002:
998:
994:
990:
986:
982:
978:
974:
970:
966:
962:
958:
954:
950:
946:
942:
938:
934:
930:
926:
922:
918:
914:
910:
906:
902:
898:
894:
890:
886:
882:
878:
874:
870:
866:
862:
858:
854:
850:
846:
842:
838:
834:
830:
828:New Caledonia
826:
822:
818:
814:
810:
806:
802:
798:
794:
790:
786:
782:
778:
774:
770:
766:
764:China Beijing
762:
758:
756:Taiwan Siraya
754:
750:
746:
742:
738:
734:
730:
726:
722:
718:
714:
710:
706:
702:
698:
694:
690:
686:
682:
678:
674:
670:
666:
662:
658:
654:
650:
646:
642:
638:
634:
630:
626:
622:
618:
614:
610:
606:
602:
598:
594:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
550:
546:
542:
539:
535:
531:
528:
524:
520:
516:
512:
504:
501:
497:
486:
482:
480:
475:
470:
466:
465:
460:
458:
457:
451:
447:
437:
433:
429:
427:
423:
419:
415:
411:
401:
392:
389:
386:
385:
381:
378:
375:
374:
370:
367:
364:
363:
359:
356:
353:
352:
348:
345:
342:
341:
337:
335:
332:
329:
328:
317:
315:
307:
304:
296:
292:
289:
285:
277:
273:
268:
261:
258:
254:
250:
247:
244:
240:
236:
230:
225:
219:
215:
210:
203:
200:
196:
192:
187:
181:
175:
169:
165:
162:
158:
154:
148:
143:
137:
133:
128:
124:
120:
117:
109:
106:
104:
100:
97:
93:
91:
87:
84:
80:
77:
75:
71:
66:
56:
49:
44:
40:
36:
31:
26:
22:
2791:
2649:
2646:J Infect Dis
2645:
2635:
2610:
2604:
2574:
2570:
2560:
2536:(2): 251–8.
2533:
2529:
2519:
2486:
2482:
2476:
2439:
2435:
2425:
2388:
2384:
2374:
2357:
2353:
2343:
2308:
2304:
2294:
2262:(3): 941–7.
2259:
2255:
2245:
2210:
2206:
2196:
2171:
2167:
2160:
2135:
2131:
2125:
2103:(5): 311–4.
2100:
2096:
2090:
2073:
2069:
2063:
2033:(4): 256–8.
2030:
2026:
2020:
1995:
1991:
1985:
1960:
1956:
1950:
1928:(2): 102–5.
1925:
1921:
1915:
1890:
1886:
1880:
1862:
1827:
1823:
1813:
1788:
1784:
1778:
1751:
1735:
1532:Taiwan Bunun
1436:Taiwan Hakka
1372:Taiwan Pazeh
1276:Israeli Jews
1068:Jordan Amman
1044:Greece North
1004:Saudi Arabia
620:Taiwan Pazeh
548:Taiwan Hakka
537:
529:uinea Madang
526:
522:
518:
483:
462:
461:
454:
443:
434:
430:
410:otosclerosis
407:
398:
333:
283:
282:
274:database at
212:Rare alleles
2489:(1): 90–6.
2076:(2): 73–9.
1824:J. Exp. Med
1658:(in %)
1594:(in %)
1484:Taiwan Tsou
1354:(in %)
988:Japan Hyogo
932:Taiwan Tsou
836:Japan Aichi
708:Taiwan Thao
612:China Wuhan
508:(in %)
286:(A11) is a
194:A11K, A11.2
156:A11E, A11.1
122:Older names
96:heterodimer
35:MHC Class I
2571:J. Immunol
2354:Cancer Res
2168:Hepatology
2132:J. Hepatol
2097:Hum. Hered
1770:References
1744:infection
1476:Taiwan Tao
1380:Taiwan Ami
1236:Turkey (2)
1212:Algeria(1)
572:Taiwan Tao
556:PNG Wosera
479:proteosome
314:haplotypes
2712:serotypes
2027:Brain Dev
1556:Japan (3)
692:USA Asian
349:size (N)
183:,
177:,
171:,
90:Structure
2871:Category
2668:16235173
2627:12753660
2511:25993298
2286:10487851
1942:10203160
1870:IMGT/HLA
1752:A11-B13
1460:Thailand
1116:Bulgaria
1036:Romanian
604:Thailand
422:epilepsy
320:Serotype
291:serotype
272:IMGT/HLA
130:Subtypes
103:Subunits
2583:9548478
2552:8900437
2503:7601573
2468:1321426
2417:3037521
2366:7627978
2335:5020429
2277:1866909
2237:7210509
2229:9619442
2207:FASEB J
2188:8188167
2152:8014443
2117:8406520
2082:8072312
2055:4706944
2047:2851270
2012:3603547
1977:3759149
1907:6983341
1854:7511684
1845:2191457
1292:Finland
1164:Morocco
489:Alleles
414:leprosy
338:Sample
293:within
284:HLA-A11
222:Subtype
189:
140:Subtype
110:*11--,
74:Protein
28:HLA-A11
2666:
2625:
2581:
2550:
2509:
2501:
2466:
2456:
2415:
2408:305131
2405:
2364:
2333:
2326:292245
2323:
2284:
2274:
2235:
2227:
2186:
2150:
2115:
2080:
2053:
2045:
2010:
1975:
1940:
1905:
1852:
1842:
1803:
1656:
1592:
1352:
1220:Brazil
1188:Serbia
506:
416:, and
343:allele
227:allele
145:allele
125:HL-A11
83:ligand
2723:HLA-A
2709:HLA-A
2507:S2CID
2459:49397
2233:S2CID
2051:S2CID
1805:77067
1653:Freq.
1589:Freq.
1349:Freq.
1180:Wales
521:apua
503:Freq.
387:*1104
376:*1103
365:*1102
360:2530
354:*1101
330:A*11
306:locus
295:HLA-A
257:*1104
252:A11.4
243:*1103
238:A11.3
199:*1102
161:*1101
108:HLA-A
68:About
2664:PMID
2623:PMID
2579:PMID
2548:PMID
2499:PMID
2464:PMID
2413:PMID
2362:PMID
2331:PMID
2282:PMID
2225:PMID
2184:PMID
2148:PMID
2113:PMID
2078:PMID
2043:PMID
2008:PMID
1973:PMID
1938:PMID
1903:PMID
1850:PMID
1801:PMID
1375:10.9
1367:12.7
967:10.0
959:10.0
951:10.4
943:10.7
935:10.8
927:10.8
919:11.0
911:11.4
908:Oman
903:11.8
895:11.9
887:12.1
879:12.3
871:12.3
863:12.5
855:12.5
847:12.5
839:12.7
831:13.1
823:14.0
815:14.0
807:15.9
799:16.0
791:16.0
783:16.2
775:16.3
767:16.4
759:17.6
751:17.7
743:17.9
735:18.0
727:19.6
719:20.4
711:21.7
703:22.2
695:23.0
687:23.5
679:24.0
671:25.2
663:26.0
655:26.2
647:26.5
639:27.1
631:27.7
623:28.2
615:29.3
607:29.9
599:30.9
591:33.8
583:35.2
575:36.0
567:38.0
559:38.5
551:40.0
543:55.0
532:63.6
474:TAP1
186:1q94
180:1qvo
174:1x7q
168:2hn7
55:2HN7
2856:A80
2851:A36
2844:A69
2839:A68
2834:A28
2827:A74
2822:A33
2817:A32
2812:A31
2807:A30
2802:A29
2797:A19
2792:A11
2785:A66
2780:A43
2775:A34
2770:A26
2765:A25
2760:A10
2753:A24
2748:A23
2654:doi
2650:192
2615:doi
2575:159
2538:doi
2491:doi
2454:PMC
2444:doi
2403:PMC
2393:doi
2321:PMC
2313:doi
2272:PMC
2264:doi
2260:155
2215:doi
2176:doi
2140:doi
2105:doi
2035:doi
2000:doi
1965:doi
1930:doi
1895:doi
1891:108
1840:PMC
1832:doi
1828:179
1793:doi
1711:0.2
1703:0.4
1695:1.0
1687:1.0
1679:1.2
1671:1.3
1623:0.2
1615:3.8
1607:5.1
1559:0.2
1551:0.6
1543:0.9
1535:1.0
1527:1.0
1519:1.0
1511:1.8
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