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hypothalamic-pituitary-adrenal axis, is also located in extrahypothalamic brain structures and may play an important role in brain emotional function. Recent use of specific corticotropin-releasing factor receptor antagonists suggests that endogenous brain corticotropin-releasing factor may be involved in specific behavioral responses to stress, the psychopathology of anxiety and affective disorders, and drug addiction. He has also characterized functional roles for other stress-related neurotransmitters/neuroregulators, such as norepinephrine, vasopressin, hypocretin (orexin), neuropeptide Y, and neuroactive steroids.
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stress systems during with the transition to dependence. To this end, he has validated key animal models for dependence associated with drugs of abuse and has begun to explore a key role of anti-reward systems in the development of dependence. The neurotransmitter systems in the extended amygdala under current investigation include corticotropin-releasing factor, norepinephrine, dynorphin, orexin, neuropeptide Y, and the sigma receptor system.
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was, until 2014, the
Director of the NIAAA Alcohol Research Center at the Scripps Research Institute, Consortium Coordinator for NIAAA's multi-center Integrative Neuroscience Initiative on Alcoholism, and Co-Director of the Pearson Center for Alcoholism and Addiction Research. He has trained 10 predoctoral and 64 postdoctoral fellows. Koob is the former Editor-in-Chief for the journal
331:
the past 3 years, his work has been focused on the role of the extended amygdala (medial shell portion of the nucleus accumbens, bed nucleus of the stria terminalis, and central nucleus of the amygdala) in behavioral responses to stress, the neuroadaptations associated with drug dependence, and compulsive drug self-administration.
351:
After reports broke that members of NIAAA staff had approached the alcohol industry for the purpose of funding a study into moderate drinking, an investigation was conducted that identified the conduct occurred prior to Koob's tenure. Koob expressed disapproval at the ethically-compromised study, and
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An authority on addiction and stress, Koob has published over 750 scientific papers and has received continuous funding for his research from the
National Institutes of Health, including the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA). He
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Finally, Koob's recent contributions include scholarly treatises on the conceptual framework and theoretical bases for understanding the neurobiology of drug addiction. He has contributed key reviews on the “dark side of addiction” in very prominent journals in the field, including Annual Review of
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In the domain of drug addiction, Koob's past work contributed significantly to our understanding of the neurocircuitry associated with the acute reinforcing effects of drugs of abuse. More recently, the focus has been on the neuroadaptations of these reward circuits and the recruitment of the brain
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His research interests continue to be directed at the neurobiology of emotion, with a focus on the theoretical constructs of reward and stress with a specific interest in understanding the neuroanatomical connections comprising the emotional systems and neurochemistry of emotional function. During
334:
Koob's work on the neurobiology of stress has included the characterization of behavioral functions in the central nervous system for catecholamines, opioid peptides, and corticotropin-releasing factor. Corticotropin-releasing factor, in addition to its classical hormonal functions in the
327:, was presented with the Distinguished Investigator Award from the Research Society on Alcoholism, and won the Mark Keller Award from NIAAA. He published a landmark book in 2006 with his colleague Michel Le Moal entitled: Neurobiology of Addiction (Academic Press-Elsevier, Amsterdam).
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Postdoctoral Fellow with Susan D. Iversen, University of
Cambridge, Department of Experimental Psychology, Medical Research Council, Neurochemical Pharmacology Unit. Studies in: catecholamines and behavior.
53:
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Staff
Scientist, Department of Neurophysiology, Walter Reed Army Institute of Research. Studies in: brain lesions, brain stimulation, behavior, neurochemistry, psychopharmacology.
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Predoctoral Fellow, Johns
Hopkins University, Department of Environmental Medicine. Training in: physiology, behavior, neurochemistry, environmental physiology.
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Norman E. Zinberg
Memorial Lecture, Department of Psychiatry, Division on Addictions, Cambridge Health Alliance, Harvard Medical School (2010).
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Professor, Molecular and
Integrative Neurosciences Department (formerly the Department of Neuropharmacology), The Scripps Research Institute.
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319:. He won the Daniel Efron Award for excellence in research from the American College of Neuropsychopharmacology, was honored as a
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Mark
Nickerson Memorial Lecture Award, Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada (2006)
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Daniel H. Efron Award, Excellence in
Research in Neuropsychopharmacology, American College of Neuropsychopharmacology (1991)
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Faculty
Excellence Award, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego (2006)
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Brain Research (Section Editor, 2008–present; Special Issue Guest Editor, Biomedical Alcohol Research, 2009, vol. 1305S)
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Associate Member (with tenure), Division of Preclinical Neuroscience and Endocrinology, The Scripps Research Institute.
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Associate Member (with tenure), Division of Preclinical Neuroscience and Endocrinology, The Scripps Research Institute.
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Staff Scientist, Arthur Vining Davis Center for Behavioral Neurobiology, The Salk Institute for Biological Studies.
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Adjunct Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego.
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Paul Stark Lecture, Department of Pharmacology and Physiology, University of Rochester Medical Center (2008)
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John C. Forbes Honors Lectureship, School of Basic Health Sciences, Virginia Commonwealth University (1991)
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Professor and Chair, Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute.
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Wendy and Stanley Marsh Endowed Lectureship, Texas Tech University Health Sciences Center, Amarillo (1999)
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Outstanding Faculty Teaching Award, Warren College, University of California, San Diego (1992, 1993, 1995)
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Adjunct Professor, Departments of Psychology and Psychiatry, University of California, San Diego.
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Outstanding UCSD Professor Award, Panhellenic Council, University of California, San Diego (2010)
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Jellinek Lectureship, Substance Abuse Treatment Unit, Yale University School of Medicine (2000)
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Outstanding Faculty Teaching Award, Revelle College, University of California, San Diego (1988)
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Outstanding Faculty Teaching Award, Muir College, University of California, San Diego (1989)
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Assistant Adjunct Professor, Department of Psychology, University of California, San Diego.
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Associate Adjunct Professor, Department of Psychiatry, University of California, San Diego.
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Associate Adjunct Professor, Department of Psychology, University of California, San Diego.
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Psychology, Nature, Neuron, and Neuropsychopharmacology, and Nature Reviews Drug Discovery.
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Grass Foundation Lecturer, Society for Neuroscience, Northern Rocky Mountain Chapter (1994)
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Louis S. Harris Sterling Drug Visiting Professor, Virginia Commonwealth University (2009).
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Grass Foundation Lecturer, Society for Neuroscience, Central New York Chapter (1990)
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Boots Distinguished Neuroscientist, Louisiana State University Medical Center (1989)
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Bowles Lectureship, Center for Alcohol Studies, University of North Carolina (2000)
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Undergraduate, Pennsylvania State University, Training in: zoology and psychology.
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Grass Foundation Lecturer, Society for Neuroscience, South Carolina Chapter (1992)
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Tharp Award, James H. Tharp Trust Committee, Research Society on Alcoholism (2002)
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Grass Foundation Lecturer, Society for Neuroscience, West Virginia Chapter (1993)
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Most Valuable Professor, Muir College, University of California, San Diego (2004)
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Grass Foundation Lecturer, Society for Neuroscience, Indianapolis Chapter (1990)
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Commencement Speaker, Warren College, University of California, San Diego (1993)
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canceled it in June 2018, while the investigation exonerated him of wrongdoing.
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Mark Keller Award, National Institute on Alcohol Abuse and Alcoholism (2004)
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Distinguished Investigator Award, Research Society on Alcoholism (2002)
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Pharmacology Biochemistry and Behavior (Editor-in-Chief, 1994–present)
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Highly Cited Researcher, Institute for Scientific Information (2001)
255:(born 1947) is a Professor and former Chair of the Committee on the
779:"Controversial NIH study of 'moderate drinking' will be terminated"
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Honorary Doctorate of Science, Pennsylvania State University (2009)
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Director, Alcohol Research Center, The Scripps Research Institute.
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Lyon-Voorhees Lectureship, University of Colorado Denver (2010).
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from the article and its talk page, especially if potentially
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Director, National Institute on Alcohol Abuse and Alcoholism
805:"Controversial alcohol study cancelled by US health agency"
519:
Journal of Addiction Medicine (Senior Editor, 2007–present)
299:(1972). Subsequently he was a post-doctoral fellow at the
840:"The Troubled End of an Ethically Compromised Booze Study"
722:"The Troubled End of an Ethically Compromised Booze Study"
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295:(1969) and a Ph.D. in Behavioral Physiology from the
755:"NIH pulls the plug on controversial alcohol trial"
281:National Institute on Alcohol Abuse and Alcoholism
237:National Institute on Alcohol Abuse and Alcoholism
199:National Institute on Alcohol Abuse and Alcoholism
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297:Johns Hopkins Bloomberg School of Public Health
908:Members of the National Academy of Medicine
883:University of California, San Diego faculty
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56:about living persons that is unsourced or
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384:ABMRF/The Foundation for Alcohol Research
127:Learn how and when to remove this message
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279:. In 2014 he became the director of the
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310:Pharmacology Biochemistry and Behavior
913:Pennsylvania State University alumni
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325:Institute for Scientific Information
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356:Professional training and positions
277:University of California, San Diego
275:and Pharmaceutical Sciences at the
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667:. The Scripps Research Institute -
291:Koob holds a B.S. in zoology from
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903:Johns Hopkins University alumni
753:Wadman, Meredith (2018-06-15).
579:Honorary Doctorate of Science,
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259:of Addictive Disorders at the
241:The Scripps Research Institute
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316:Journal of Addiction Medicine
293:Pennsylvania State University
170:Pennsylvania State University
803:Reardon, Sara (2018-06-15).
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34:biography of a living person
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838:Rogers, Adam (2018-06-25).
720:Rogers, Adam (2018-06-25).
161:1947 (age 76–77)
61:must be removed immediately
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817:10.1038/d41586-018-05461-x
382:Medical Advisory Counsel,
261:Scripps Research Institute
273:Skaggs School of Pharmacy
263:and Adjunct Professor of
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893:Scripps Research faculty
465:University Affiliation:
179:Johns Hopkins University
898:Medical journal editors
321:highly cited researcher
301:University of Cambridge
581:University of Bordeaux
48:Please help by adding
665:"Faculty:George Koob"
533:Alpha Zeta Fraternity
347:Cancelled NIAAA Study
54:Contentious material
554:ASAM Annual Award,
696:"Director's Page"
530:Phi Sigma Society
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228:of drug addiction
216:Scientific career
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855:. Retrieved
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43:verification
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878:1947 births
671:7 September
586:Chevalier,
143:George Koob
872:Categories
857:2019-05-21
789:2019-05-21
764:2019-05-21
739:2019-05-21
648:References
503:1980-1983
495:1987-1989
487:1983-1989
456:1965-1969
448:1969-1972
440:1972-1975
431:1975-1977
423:1977-1983
415:1983-1989
407:1983-1989
399:1990-2006
379:1999–2003
371:2006–2014
269:Psychiatry
265:Psychology
194:Occupation
87:newspapers
852:1059-1028
825:158913351
734:1059-1028
323:from the
287:Biography
166:Education
39:citations
705:20 April
526:Awards:
65:libelous
101:scholar
850:
823:
809:Nature
732:
583:(2013)
558:(2002)
271:, and
222:Fields
205:Awards
103:
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844:Wired
821:S2CID
726:Wired
108:JSTOR
94:books
32:This
848:ISSN
783:STAT
730:ISSN
707:2015
673:2010
158:Born
80:news
41:for
813:doi
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187:PhD
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