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Environmental toxicants and fetal development

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479:(Benzene, toluene, ethylbenzene, xylenes) exposure during the first trimester of pregnancy has been clearly indicating negative association with biparietal brain diameter between 20 and 32 weeks of pregnancy. Women with high exposure to toluene had three to five times the miscarriage rate of those with low exposure, and women with occupational benzene exposure have been shown to have an increased rate of miscarriages. Paternal occupational exposure to toluene and formaldehyde has also been linked to miscarriage in their partners. Normal development is highly controlled by hormones, and disruption by man made chemicals can permanently change the course of development. Ambient ozone has been negatively associated with sperm concentration in men, chemicals associated with UOG operations (e.g., benzene, toluene, formaldehyde, ethylene glycol and ozone) have been associated with negative impacts on semen quality, particularly reduced sperm counts. 416:(PM) consist of a mixture of particle pollutants that remain in the air, and vary be region. These particles are very small, ranging from PM10 to PM 2.5, which can easily enter the lungs. Particulate matter has been shown to be associated with acute cardio-respiratory morbidity and mortality. Intrauterine growth has been shown to be affected by particulate matter, leading to unhealthy outcomes for fetal development such as poor or slow fetal growth, and increasing fetal morbidity and mortality. A study from 2012 found that exposures to PM 2.5 differed by race/ethnicity, age, as well as socioeconomic status, leading to certain populations experiencing greater negative health outcomes due to environmental pollution, especially relating to 367:
cause damage to the kidneys, bones, and neurological systems. Pregnant women are at higher risk of health issues from cadmium due to increased absorption of the metal during pregnancy. Cadmium can also pose health risks to the fetus,  some of which may be lifelong, as it interferes with placental function and fetal development. There has been evidence of changes in birth size associated with high levels of cadmium exposure, particularly in female children. Although studies show that relatively low levels of cadmium exposure can affect pregnancy outcomes, more studies must be done to confirm these effects, establish updated exposure limitation guidelines, and explore ways to decrease exposure, particularly during pregnancy.
444:(a fungicide). Although pesticide toxicity is not as frequently mentioned as some of the other methods of environmental toxicity, such as air pollution, contamination can occur at any time from merely engaging in everyday activities such as walking down a pathway near a contaminated area, or eating foods that have not been washed properly. In 2007 alone, 1.1 billion pounds (500 kt) of pesticides were found present in the environment, causing pesticide exposure to gain notoriety as a new cause of caution to those wishing to preserve their health. 708:, it is unable to detoxify substances very efficiently; and as the placenta plays such an important role in substance exchange between the mother and the fetus, it goes without saying that any toxic substances that the mother is exposed to are transported to the fetus, where they can then affect development. Carbon-dioxide, lead, ethanol (alcohol), and cigarette smoke in particular are all substances that have a high likelihood of placental transferral. 50:. The human embryo or fetus is relatively susceptible to impact from adverse conditions within the mother's environment. Substandard fetal conditions often cause various degrees of developmental delays, both physical and mental, for the growing baby. Although some variables do occur as a result of genetic conditions pertaining to the father, a great many are directly brought about from environmental toxins that the mother is exposed to. 402:
found virtually everywhere, there are specific sources that have been known to release toxic substances and should be avoided if possible by those who wish to remain relatively free of toxins. These substances include, but are not limited to: steel mills, waste/water treatment plants, sewage incinerators, automotive fabrication plants, oil refineries, and chemical manufacturing plants.
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nervous system of an embryo or fetus, sometimes leading to learning disabilities. Mercury is present in many types of fish, but it is mostly found in certain large fish. One well-documented case of widespread mercury ingestion and subsequent fetal development complication took place in the 1950s in Minamata Bay, Japan. Used by a nearby industrial plant in the manufacture of plastics,
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toxin; however, the mercury especially impacted pregnant women and their fetuses, resulting in a high rate of miscarriage. Surviving infants exposed to mercury in-utero had extremely high rates of physical and intellectual disabilities, as well as physical abnormalities from exposure in the womb during key stages in fetal physical development. The United States
632:, as well as change hormone concentrations within the body, leading to incorrect hormone responses in the body as well as disrupt normal enzyme functioning. Oil and gas extraction has been known to contribute to EDCs in the environment, largely due to the high risk of ground and surface water contamination that comes with these extractions. In addition to 609:(NTDs). Along with this finding, a small association was found between mean birth weight and the density and proximity to the natural gas wells. Maternal exposure through natural gas wells may come in the form of benzene, solvents, polycyclic aromatic hydrocarbons (PAHs), and other air pollutants such as toluene, nitrogen dioxide, and sulfur dioxide. 95:(BPA) was identified in 96 percent of the women surveyed. Several of the chemicals were at the same concentrations that have been associated with negative effects in children from other studies and it is thought that exposure to multiple chemicals can have a greater impact than exposure to only one substance. 451:
pesticides found all but one showed negative neurodevelopmental outcomes. In the ten studies that assessed prenatal exposure, "cognitive deficits (related to working memory) were found in children at age 7 years, behavioral deficits (related to attention) seen mainly in toddlers, and motor deficits
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persists in the environment for a long time and are widespread, so all people have some amount of dioxins in the body. Intrauterine exposure to dioxins and dioxin-like compounds have been associated with subtle developmental changes on the fetus. Effects on the child later in life include changes in
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Manduca, Paola, Awny Naim, and Simona Signoriello. "Specific Association of Teratogen and Toxicant Metals in Hair of Newborns with Congenital Birth Defects or Developmentally Premature Birth in a Cohort of Couples with Documented Parental Exposure to Military Attacks: Observational Study at Al Shifa
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was conducted to assess the need for an endocrine component to health assessments for drilling and extraction of oil and gas in densely populated areas. With the high potential for release of oil and gas chemicals with extraction, specifically chemicals that have been shown to disrupt normal hormone
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and nitrogen dioxide all have the potential to cause serious damage when inhaled by an expecting mother. Low birth weight, preterm birth, intrauterine growth retardation, and congenital abnormalities have all been found to be associated with fetal exposure to air pollution. Although pollution can be
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The developing nervous system of the fetus is particularly vulnerable to lead toxicity. Neurological toxicity is observed in children of exposed women as a result of the ability of lead to cross the placental barrier. A special concern for pregnant women is that some of the bone lead accumulation is
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are created for the specific purpose of causing harm (to insects, rodents, and other pests), pesticides have the potential to cause serious damages to a developing fetus, should they be introduced into the fetal environment. Studies have shown that pesticides, particularly fungicides, have shown up
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in pregnancy. Methylmercury, a worldwide contaminant of seafood and freshwater fish, is known to produce adverse nervous system effects, especially during brain development. Eating fish is the main source of mercury exposure in humans and some fish may contain enough mercury to harm the developing
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Cadmium is a heavy metal that the United States Environmental Protection Agency classifies as a probable human carcinogen. People are often exposed to cadmium through various industrial and agricultural sources, and diet is considered the primary exposure method. The heavy metal has been shown to
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In 2017, a study looked at the possible effects of agricultural pesticides in over 500,000 births in a largely agricultural region of California and compared their findings to birth outcomes in other less agriculturally dominated California areas. Overall, they found that pesticide exposure
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Control of air pollution can be difficult. For example, in Los Angeles, regulations have been made to control pollution by putting rules on industrial and vehicle emissions. Improvements have been made to meet these regulations. Despite these improvements, the region still does not meet federal
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was discharged into the waters of Minamata Bay, where it went on to be ingested regularly by many villagers who used the fish living in the bay as a dietary staple. Soon, many of the inhabitants who had been consuming the mercury-laden meat began experiencing negative effects from ingesting the
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One in ten US babies is born preterm and about 5% have low birth weight. Preterm birth, defined as birth at less than 37 weeks of gestation, is a major basis of infant mortality throughout childhood. Exposures to environmental toxins such as lead, tobacco smoke, and DDT have been linked with an
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of neurodevelopmental effects of prenatal and postnatal organophosphate pesticide exposure was done in 2014. The review found that "Most of the studies evaluating prenatal exposure observed a negative effect on mental development and an increase in attention problems in preschool and school
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In Pennsylvania, unconventional natural gas producing wells increased from zero in 2005 to 3689 in 2013. A 2016 study of 9384 mothers and 10946 neonates in the Geisinger Health System in Pennsylvania found prenatal residential exposure to unconventional natural gas development activity was
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may experience a wide range of behavioral, neurological, and physical difficulties. Adverse effects include stillbirth, placental disruption, prematurity, lower mean birth weight, physical birth defects (cleft palate etc.), decrements in lung function, increased risk of infant mortality.
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to cause autism in vulnerable individuals. These findings regarding autism are controversial, however, with many researchers believing that increasing rates in certain areas are a consequence of more accurate screening and diagnostic methods, and are not due to any sort of
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If living in a home built before 1978, checking whether lead paint has been used. If such is the case, paint that is crumbling or peeling should not be touched, a professional should remove the paint and the site should be avoided while the paint is removed or
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González-Alzaga B, Lacasaña M, Aguilar-Garduño C, Rodríguez-Barranco M, Ballester F, Rebagliato M, Hernández AF (2014). "A systematic review of neurodevelopmental effects of prenatal and postnatal organophosphate pesticide exposure".
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Substances which have been found to be particularly harmful are lead (which is stored in the mother's bones), cigarette smoke, alcohol, mercury (a neurological toxicant consumed through fish), carbon dioxide, and ionizing radiation.
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drilling has been found to be associated with decreased birth weight. It was unclear which route of exposure: air, soil or water could be attributed to the association. Further research and larger studies on this topic are needed.
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Various toxins pose a significant hazard to fetuses during development. A 2011 study found that virtually all US pregnant women carry multiple chemicals, including some banned since the 1970s, in their bodies. Researchers detected
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MinguillĂłn, M.C.; Schembari, A.; Triguero-Mas, M.; de Nazelle, A.; Dadvand, P.; Figueras, F.; Salvado, J.A.; Grimalt, J.O.; Nieuwenhuijsen, M.; Querol, X. (2012). "Source apportionment of indoor, outdoor and personal
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PBDEs, compounds used as flame retardants, and dichlorodiphenyltrichloroethane (DDT), a pesticide banned in the United States in 1972, in the bodies of 99 to 100 percent of the pregnant women they tested. Among other
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production and function, the authors highly emphasized the need for a component centering around endocrine function and overall health with health assessments, and how this in turn impacts the environment.
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Gustin, Klara; Barman, Malin; StrĂĄvik, Mia; Levi, Michael; Englund-Ă–gge, Linda; Murray, Fiona; Jacobsson, Bo; Sandberg, Ann-Sofie; Sandin, Anna; Wold, Agnes E.; Vahter, Marie; Kippler, Maria (2020-10-01).
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Environmental toxicants can be described separately by what effects they have, such as structural abnormalities, altered growth, functional deficiencies, congenital neoplasia, or even death for the fetus.
2560:"Environmental causes of human congenital malformations: The pediatrician's role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors" 640:, creating another route of exposure for these endocrine disruptors. This problem often goes under-reported, and therefore, the true magnitude of the impact is underestimated. In 2016, a 358:
released into the blood during pregnancy. Several studies have provided evidence that even low maternal exposures to lead produce intellectual and behavioral deficits in children.
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Pohl, Hana R.; Smith-Simon, Cassandra; Hicks, Heraline (1998). "Health Effects Classification and Its Role in the Derivation of Minimal Risk Levels: Developmental Effects".
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substances. However, it is by design an imperfect barrier since it must transport substances required for growth and development. Placental transport can be by passive
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Avoiding any cleaning supply labeled "toxic" or any product with a warning on the label, and instead trying natural products, baking soda, vinegar and/or water to clean.
2494:"Endocrine- disrupting chemicals and oil and natural gas operations: potential environmental contamination and recommendations to assess complex environmental mixtures" 711:
Identifying potential hazards for fetal development requires a basis of scientific information. In 2004, Brent proposed a set of criteria for identifying causes of
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standards for ozone and particulate matter. Approximately 150,000 births occur every year in Los Angeles. Thus, any effects air pollution has on human development
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Le, Hien Q.; Batterman, Stuart A.; Wirth, Julia J.; Wahl, Robert L.; Hoggatt, Katherine J.; Sadeghnejad, Alireza; Hultin, Mary Lee; Depa, Michael (2012).
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are compounds that can disrupt the normal development and normal hormone levels in humans. Endocrine-disrupting chemicals (EDCs) can interact with
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advise pregnant women not to eat swordfish, shark, king mackerel and tilefish and limit consumption of albacore tuna to 6 ounces or less a week.
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Avoiding paint supplies such as stained glass material, oil paints and ceramic glazes, and instead using watercolor or acrylic paints and glazes.
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can negatively affect a pregnancy resulting in higher rates of preterm births, growth restriction, and heart and lung problems in the infant.
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development, maternal residence within a 10-mile radius of natural gas wells was found to have a positive association to the prevalence of
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Hospital, Gaza, Palestine." International Journal of Environmental Research and Public Health. N.p., 14 May 2014. Web. 25 July 2014. <
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of a substance received by the fetus is determined by the amount of the substance transported across the placenta as well as the rate of
998: 1655:"Air pollutant exposure and preterm and term small-for-gestational-age births in Detroit, Michigan: Long-term trends and associations" 1459:
Kippler, Maria; Tofail, Fahmida; Gardner, Renee; Rahman, Anisur; Hamadani, Jena D.; Bottai, Matteo; Vahter, Marie (February 2012).
3698: 3693: 2355: 1032:"Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls" 2418: 2193: 1961:
Muñoz-Quezada MT, Lucero BA, Barr DB, Steenland K, Levy K, Ryan PB, Iglesias V, Alvarado S, Concha C, Rojas E, Vega C (2013).
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increased adverse birth outcomes by 5–9%, but only among those mothers exposed to the highest quantities of pesticides.
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in pregnancy include miscarriage, low birth weight, neurological delays, anemia, encephalopathy, paralysis, blindness,
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are related to particular geographic locations, implying that something in the environment is complementing an at-risk
3466: 3331: 2702: 2679: 2660: 2641: 929: 375: 231: 1963:"Neurodevelopmental effects in children associated with exposure to organophosphate pesticides: a systematic review" 1519:"Low-level maternal exposure to cadmium, lead, and mercury and birth outcomes in a Swedish prospective birth-cohort" 1186: 3570: 3270: 2795: 2559: 2141:"Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations" 185: 79: 3622: 3336: 272: 160: 3386: 71: 1355:"Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models" 3411: 3318: 2820: 2138: 147:
s. They are agents extrinsic to embryo or fetus which exert deleterious effects leading to increased risk of
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More Than Genes: What Science Can Tell Us About Toxic Chemicals, Development, and the Risk to Our Children
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Casey J. A., Savitz D. A., Rasmussen S. G., Ogburn E. L., Pollak J., Mercer D. G., Schwartz B. S. (2015).
2196:"Maternal Exposure to Ambient Levels of Benzene and Neural Tube Defects among Offspring: Texas, 1999–2004" 3245: 3056: 3029: 2534: 942:
Wing L.; Potter D. (2002). "The epidemiology of autistic spectrum disorders: is the prevalence rising?".
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recommends the following precautions to minimize exposure to relevant environmental toxins in pregnancy:
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exposure in mothers has been linked to fetal brain defects especially neural tube defects. In one study,
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Stacy S. L., Brink L. L., Larkin J. C., Sadovsky Y., Goldstein B. D., Pitt B. R., Talbott E. O. (2015).
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Lupo P. J., Symanski E., Waller D. K., Chan W., Langlois P. H., Canfield M. A., Mitchell L. E. (2010).
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Animal studies provide evidence of the correlation between substance exposures and particular effects.
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Daftary, Shirish; Chakravarti, Sudip (2011). Manual of Obstetrics, 3rd Edition. Elsevier. pp. 38-41.
59: 55: 1906:"Reduced birth weight in relation to pesticide mixtures detected in cord blood of full-term infants" 2863: 1904:
Wickerham, Erin L.; Lozoff, Betsy; Shao, Jie; Kaciroti, Niko; Xia, Yankai; Meeker, John D. (2012).
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studies consistently show a relationship between particular effects and exposure to the substance.
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Data trends support a relationship between changing levels of exposure and the specific effect.
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Jacobo-Estrada, Tania; Santoyo-Sánchez, Mitzi; Thévenod, Frank; Barbier, Olivier (July 2017).
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and physician-recorded high-risk pregnancy. In Southwest Pennsylvania, maternal proximity to
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A 2011 study found a relationship between Neural Tube Defects and maternal exposure to
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Webb E., Bushkin-Bedient S., Cheng A., Kassotis C. D., Balise V., Nagel S. C. (2014).
38:. This article deals with potential adverse effects of environmental toxicants on the 3525: 3401: 3140: 3081: 2921: 2901: 2896: 2698: 2691: 2675: 2656: 2637: 2631: 2616: 2579: 2526: 2460: 2387: 2338: 2225: 2162: 2121: 2103: 2042: 1992: 1943: 1879: 1808: 1692: 1632: 1564: 1556: 1498: 1480: 1441: 1433: 1394: 1376: 1335: 1327: 1288: 1280: 1241: 1233: 1146: 1105: 1061: 959: 925: 885: 829: 794: 629: 456: 315: 307: 2591: 1158: 3496: 3108: 2981: 2976: 2870: 2571: 2516: 2508: 2450: 2440: 2377: 2369: 2328: 2320: 2266: 2215: 2207: 2152: 2111: 2095: 2034: 1982: 1974: 1933: 1925: 1869: 1853: 1798: 1782: 1736: 1732: 1682: 1674: 1622: 1614: 1546: 1538: 1488: 1472: 1425: 1384: 1366: 1319: 1272: 1225: 1136: 1095: 1051: 1043: 951: 875: 865: 821: 784: 776: 685: 437: 380: 765:"Environmental Chemicals in Pregnant Women in the United States: NHANES 2003–2004" 3545: 3260: 3155: 3024: 2916: 2805: 2754: 2445: 2373: 2038: 1929: 1678: 1618: 1588: 1542: 1082:
Abelsohn, A; Vanderlinden, LD; Scott, F; Archbold, JA; Brown, TL (January 2011).
870: 689: 648: 448: 200: 2358:"Unconventional Natural Gas Development and Birth Outcomes in Pennsylvania, USA" 1978: 210:
Interfering with cell proliferation rate, such as viral infection and ionization
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Heat and noise have also been found to have significant effects on development.
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increased risk for spontaneous abortion, low birth weight, or preterm birth.
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levels were more likely to have offspring with neural tube defects, such as
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Drinking alcohol in pregnancy can result in a range of disorders known as
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A 2013 review of 27 studies on prenatal and early childhood exposures to
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levels, and decreased performance in tests of learning and intelligence.
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McKenzie LM, Guo R, Witter RZ, Savitz DA, Newman LS, Adgate JL (2014).
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Dejmek J., Selevan S. G., Benes I., Solansky I., Sram R. J. (1999).
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Mental Retardation and Developmental Disabilities Research Reviews
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thoroughly, peeling the skin from fruits and vegetables or buying
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Chudley, T. V. N.; Persaud, A. E.; Skalko, Richard G. (1985).
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Kassotis CD, Tillitt DE, Lin CH, McElroy JA, Nagel SC (2016).
1600: 1308:"Current status of cadmium as an environmental health problem" 1261:"Current status of cadmium as an environmental health problem" 840: 664:
is a semipermeable membrane that does form a barrier for most
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Abnormal cellular or tissue interactions, as seen in diabetes
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Altered biosynthetic pathways, as seen in chromosomal defects
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Threshold interaction of genes with environmental teratogens
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Teratogens affect the fetus by various mechanism including:
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Mercury exposure in pregnancy may also cause limb defects.
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Perchlorate Levels in Pregnancy Linked to Low Childhood IQ
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Backes, CH; Nelin, T; Gorr, MW; Wold, LE (Jan 10, 2013).
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from Minnesota Department of Health. Updated October 2006
692:. Some toxic chemicals may be actively transported. The 1314:. New Insights into the Mechanisms of Cadmium Toxicity. 1267:. New Insights into the Mechanisms of Cadmium Toxicity. 851: 137:
Toxic substances that are capable of causing structural
2306: 1758:. UCLA Institute of the Environment and Sustainability. 1515: 636:, oil and gas extraction also lead to higher levels of 535: 410:
are of great concern to those who live in this region.
1603:"Early life exposure to air pollution: how bad is it?" 763:
Woodruff, T. J.; Zota, A. R.; Schwartz, J. M. (2011).
167:. Teratogens are classified in four main categories: 2650: 1652: 1030:
Hackshaw, A; Rodeck, C; Boniface, S (Sep–Oct 2011).
811: 762: 122: 688:for substances that are larger and/or electrically 543:
Avoiding relevant environmental toxins in pregnancy
174:– in addition to environmental chemicals, includes 2693:Having Faith: An Ecologist's Journey to Motherhood 2690: 2630:Buelke-Sam, Judy; Kimmel, Carol A., eds. (1994). 1839: 1743: 1715:exposure of pregnant women in Barcelona, Spain". 3670: 2629: 941: 704:of the substance. As the fetus has an immature 566:and changing water drinking habits if necessary. 314:are two forms of mercury that may pose risks of 1752:"Air Pollution Impacts on Infants and Children" 854:"Protecting Children from Environmental Toxins" 452:(abnormal reflexes), seen mainly in neonates." 34:from the environment on the development of the 2259:"Controlled Antenatal Thyroid Screening study" 1703: 1017:Alcohol Use in Pregnancy | FASD | NCBDDD | CDC 339:are theorized to originate from war weaponry. 257: 226: 2727: 2074:Larsen, Ashley; Gaines, Steven (2017-08-29). 1756:Southern California Environmental Report Card 1187:"Chapter 1, Lead-based Paint Hazards, 98–112" 28:Environmental toxicants and fetal development 2741: 2477:: CS1 maint: multiple names: authors list ( 2404:: CS1 maint: multiple names: authors list ( 2242:: CS1 maint: multiple names: authors list ( 2179:: CS1 maint: multiple names: authors list ( 2073: 2059:: CS1 maint: multiple names: authors list ( 2009:: CS1 maint: multiple names: authors list ( 1825:: CS1 maint: multiple names: authors list ( 1594: 1305: 1258: 1122: 2688: 1749: 1359:International Journal of Molecular Sciences 1306:Järup, Lars; Ă…kesson, Agneta (2009-08-01). 1259:Järup, Lars; Ă…kesson, Agneta (2009-08-01). 1077: 1075: 985: 983: 981: 979: 977: 975: 973: 2734: 2720: 999:Centers for Disease Control and Prevention 592: 498:, than mothers living in areas with lower 2674:(3rd ed.). New York: Marcel Dekker. 2669: 2551: 2520: 2454: 2444: 2381: 2332: 2270: 2219: 2156: 2115: 1986: 1937: 1873: 1802: 1686: 1626: 1550: 1492: 1418:Environmental Toxicology and Pharmacology 1388: 1370: 1218:Environmental Toxicology and Pharmacology 1140: 1099: 1055: 879: 869: 788: 2297:Volume 51, No. 1, January/February 2006. 2285:, by Nancy A. Melville, October 22, 2013 1411: 1211: 1072: 970: 379:liver function, thyroid hormone levels, 2636:(2nd ed.). New York: Raven Press. 1750:Ritz, Beate; Wilhelm, Michelle (2008). 1412:Geng, Hui-Xia; Wang, Lai (2019-04-01). 1212:Geng, Hui-Xia; Wang, Lai (2019-04-01). 1023: 655: 14: 3671: 2295:Environmental Hazards During Pregnancy 814:Regulatory Toxicology and Pharmacology 2715: 2697:. Cambridge, MA: Perseus Publishing. 2615:. New York: Oxford University Press. 2557: 989: 2608: 3566:Psychiatric disorders of childbirth 2256: 1312:Toxicology and Applied Pharmacology 1265:Toxicology and Applied Pharmacology 1005: 397:Compounds such as carbon monoxide, 335:High mercury levels in newborns in 24: 2602: 1174:http://www.mdpi.com/journal/ijerph 549:American College of Nurse-Midwives 25: 3710: 2670:Schardein, James L., ed. (2000). 2200:Environmental Health Perspectives 1846:Environmental Health Perspectives 1775:Environmental Health Perspectives 1465:Environmental Health Perspectives 769:Environmental Health Perspectives 719:in general. Those criteria are: 534:causes a significant risk of low 376:Dioxins and dioxin-like compounds 232:Neuroplastic effects of pollution 186:Vertically transmitted infections 123:Structural congenital abnormality 18:Environmental toxins in pregnancy 3571:Postpartum physiological changes 3271:Postpartum physiological changes 2796:Assisted reproductive technology 2672:Chemically Induced Birth Defects 386: 282: 273:fetal alcohol spectrum disorders 113: 80:polycyclic aromatic hydrocarbons 3623:Adaptation to extrauterine life 2485: 2412: 2349: 2300: 2288: 2250: 2187: 2145:Reviews on Environmental Health 2132: 2067: 2017: 1954: 1833: 1762: 1575: 1509: 1452: 1405: 1346: 1299: 1252: 1205: 1179: 1165: 1125:"Mercury Toxicity, An Overview" 1116: 330:Environmental Protection Agency 3699:Occupational safety and health 3694:Environmental impact by effect 3266:Maternal physiological changes 1737:10.1016/j.atmosenv.2012.04.052 935: 918: 896: 756: 275:. The most severe of these is 72:polybrominated diphenyl ethers 13: 1: 2821:partner-assisted reproduction 749: 597:In a rural Colorado study of 423: 2689:Steingraber, Sandra (2001). 2653:Basic Concepts in Teratology 2446:10.1371/journal.pone.0126425 2374:10.1097/ede.0000000000000387 2039:10.1016/j.toxlet.2013.11.019 1930:10.1016/j.envint.2012.06.007 1679:10.1016/j.envint.2012.01.003 1619:10.1016/j.toxlet.2012.11.007 1543:10.1016/j.envpol.2020.114986 871:10.1371/journal.pmed.0020061 715:that also are applicable to 558:Checking the quality of the 326:Food and Drug Administration 236:neurodevelopmental disorders 7: 3057:Traditional birth attendant 1979:10.1016/j.neuro.2013.09.003 737: 467: 432:in analyses of an infant's 258:Toxicants and their effects 227:Neurodevelopmental disorder 199:Mechanical forces, such as 30:is the impact of different 10: 3715: 3289:Brain health and pollution 2655:. New York: Alan R. Liss. 2100:10.1038/s41467-017-00349-2 1840:Bell M., Ebisu K. (2012). 1430:10.1016/j.etap.2019.02.006 1324:10.1016/j.taap.2009.04.020 1277:10.1016/j.taap.2009.04.020 1230:10.1016/j.etap.2019.02.006 1142:10.1177/216507998603401106 526:Environmental exposure to 361: 301: 286: 266: 126: 105:Brain health and pollution 102: 98: 3650: 3615: 3579: 3533: 3524: 3502:Chorionic villus sampling 3484: 3279: 3236: 3205: 3198: 3065: 2990: 2959: 2950: 2884: 2854:Obstetric ultrasonography 2841: 2786: 2778:Pre-conception counseling 2753: 2558:Brent, Robert L. (2004). 1910:Environment International 1659:Environment International 1189:. Cdc.gov. Archived from 1088:Canadian Family Physician 1036:Human Reproduction Update 370: 60:organochlorine pesticides 56:polychlorinated biphenyls 3392:Intrahepatic cholestasis 2633:Developmental Toxicology 713:congenital malformations 603:congenital heart defects 573:To decrease exposure to 505: 139:congenital abnormalities 64:perfluorinated compounds 3462:Motor vehicle emissions 3323:Concomitant conditions 3297:environmental toxicants 3040:Auxiliary nurse midwife 2801:artificial insemination 2768:Natural family planning 2576:10.1542/peds.113.S3.957 2501:Environ Health Perspect 2313:Environ Health Perspect 2158:10.1515/reveh-2014-0057 1717:Atmospheric Environment 1523:Environmental Pollution 593:Natural gas development 345: 89:environmental estrogens 48:pregnancy complications 3556:Postpartum confinement 2816:in vitro fertilisation 2272:10.1186/ISRCTN46178175 826:10.1006/rtph.1998.1232 717:developmental toxicity 295:prenatal tobacco smoke 277:fetal alcohol syndrome 133:Congenital abnormality 3551:Postpartum depression 3432:Pruritic folliculitis 3176:Unassisted childbirth 2080:Nature Communications 1123:Burt Susan D (1986). 1048:10.1093/humupd/dmr022 289:Smoking and pregnancy 176:recreational drug use 127:Further information: 46:or fetus, as well as 3658:Gravidity and parity 3638:Congenital disorders 3597:Lactation consultant 3467:Pre-existing disease 3146:Childbirth positions 3136:Rupture of membranes 2833:Unintended pregnancy 2811:fertility medication 2277:. Also described in 1582:Facts about Dioxins. 1372:10.3390/ijms18071590 993:(January 17, 2013). 656:Role of the placenta 626:Endocrine disruptors 585:produce if possible. 490:with higher ambient 252:environmental factor 180:pharmaceutical drugs 159:, altered function, 40:prenatal development 3561:Sex after pregnancy 3368:Endocrine diseases 3314:Prenatal depression 3186:Placental expulsion 3104:Uterine contraction 3087:cervical effacement 2828:Fertility awareness 2570:(4 Suppl): 957–68. 2513:10.1289/ehp.1409535 2437:2015PLoSO..1026425S 2325:10.1289/ehp.1306722 2212:10.1289/ehp.1002212 2092:2017NatCo...8..302L 1922:2012EnInt..47...80W 1858:10.1289/ehp.1205201 1729:2012AtmEn..59..426M 1671:2012EnInt..44....7L 1535:2020EPoll.26514986G 1477:10.1289/ehp.1103711 1013:"Facts About FASDs" 781:10.1289/ehp.1002727 634:water contamination 607:neural tube defects 350:Adverse effects of 3337:Hypercoagulability 3166:Natural childbirth 3015:Postterm pregnancy 2773:Male contraceptive 2609:Agin, Dan (2009). 1607:Toxicology Letters 1587:2019-02-02 at the 1193:on 29 October 2011 956:10.1002/mrdd.10029 744:Drugs in pregnancy 647:2017-05-06 at the 619:unconventional gas 521:Ionizing radiation 418:particulate matter 414:Particulate matter 293:Fetal exposure to 172:Drugs in pregnancy 3666: 3665: 3651:Obstetric history 3646: 3645: 3607:Confinement nanny 3520: 3519: 3387:Acute fatty liver 3194: 3193: 3082:cervical dilation 2622:978-0-19-538150-4 1852:(12): 1699–1704. 630:hormone receptors 457:systematic review 316:mercury poisoning 234:can give rise to 219:Extrinsic factors 165:pregnancy wastage 16:(Redirected from 3706: 3531: 3530: 3497:Cardiotocography 3203: 3202: 3109:Vaginal delivery 2982:Nesting instinct 2957: 2956: 2942:Rudimentary horn 2871:Prenatal testing 2736: 2729: 2722: 2713: 2712: 2708: 2696: 2685: 2666: 2647: 2626: 2596: 2595: 2555: 2549: 2548: 2546: 2545: 2539: 2533:. Archived from 2524: 2498: 2489: 2483: 2482: 2476: 2468: 2458: 2448: 2416: 2410: 2409: 2403: 2395: 2385: 2353: 2347: 2346: 2336: 2304: 2298: 2292: 2286: 2276: 2274: 2254: 2248: 2247: 2241: 2233: 2223: 2191: 2185: 2184: 2178: 2170: 2160: 2136: 2130: 2129: 2119: 2071: 2065: 2064: 2058: 2050: 2021: 2015: 2014: 2008: 2000: 1990: 1958: 1952: 1951: 1941: 1901: 1888: 1887: 1877: 1837: 1831: 1830: 1824: 1816: 1806: 1766: 1760: 1759: 1747: 1741: 1740: 1707: 1701: 1700: 1690: 1650: 1641: 1640: 1630: 1598: 1592: 1579: 1573: 1572: 1554: 1529:(Pt B): 114986. 1513: 1507: 1506: 1496: 1456: 1450: 1449: 1409: 1403: 1402: 1392: 1374: 1350: 1344: 1343: 1303: 1297: 1296: 1256: 1250: 1249: 1209: 1203: 1202: 1200: 1198: 1183: 1177: 1169: 1163: 1162: 1144: 1120: 1114: 1113: 1103: 1079: 1070: 1069: 1059: 1027: 1021: 1020: 1019:. 9 August 2017. 1009: 1003: 1002: 987: 968: 967: 939: 933: 922: 916: 915: 913: 911: 906:. dictionary.com 900: 894: 893: 883: 873: 849: 838: 837: 809: 803: 802: 792: 760: 686:active transport 668:and for certain 613:associated with 438:diethyltoluamide 381:white blood cell 161:deficient growth 32:toxic substances 21: 3714: 3713: 3709: 3708: 3707: 3705: 3704: 3703: 3669: 3668: 3667: 3662: 3642: 3611: 3575: 3546:Postpartum care 3516: 3480: 3383:Liver diseases 3377:Thyroid disease 3275: 3261:Gestational age 3232: 3190: 3156:Labor induction 3061: 3052:Perinatal nurse 3025:Birth attendant 2986: 2946: 2880: 2876:Medical imaging 2837: 2806:fertility fraud 2782: 2749: 2740: 2705: 2682: 2663: 2644: 2623: 2605: 2603:Further reading 2600: 2599: 2556: 2552: 2543: 2541: 2537: 2496: 2490: 2486: 2470: 2469: 2431:(6): e0126425. 2417: 2413: 2397: 2396: 2354: 2350: 2305: 2301: 2293: 2289: 2257:Lazarus, J. H. 2255: 2251: 2235: 2234: 2192: 2188: 2172: 2171: 2137: 2133: 2072: 2068: 2052: 2051: 2022: 2018: 2002: 2001: 1967:Neurotoxicology 1959: 1955: 1902: 1891: 1838: 1834: 1818: 1817: 1787:10.2307/3434630 1767: 1763: 1748: 1744: 1714: 1708: 1704: 1651: 1644: 1599: 1595: 1589:Wayback Machine 1580: 1576: 1514: 1510: 1457: 1453: 1410: 1406: 1351: 1347: 1304: 1300: 1257: 1253: 1210: 1206: 1196: 1194: 1185: 1184: 1180: 1170: 1166: 1135:(11): 543–546. 1121: 1117: 1080: 1073: 1028: 1024: 1011: 1010: 1006: 988: 971: 940: 936: 923: 919: 909: 907: 902: 901: 897: 850: 841: 810: 806: 761: 757: 752: 740: 723:Well-conducted 658: 649:Wayback Machine 595: 545: 508: 470: 449:organophosphate 426: 389: 373: 364: 348: 304: 291: 285: 269: 260: 229: 201:oligohydramnios 135: 125: 116: 107: 101: 23: 22: 15: 12: 11: 5: 3712: 3702: 3701: 3696: 3691: 3686: 3681: 3664: 3663: 3661: 3660: 3654: 3652: 3648: 3647: 3644: 3643: 3641: 3640: 3635: 3630: 3625: 3619: 3617: 3613: 3612: 3610: 3609: 3604: 3599: 3594: 3592:Health visitor 3589: 3583: 3581: 3577: 3576: 3574: 3573: 3568: 3563: 3558: 3553: 3548: 3543: 3537: 3535: 3528: 3522: 3521: 3518: 3517: 3515: 3514: 3509: 3507:Nonstress test 3504: 3499: 3494: 3488: 3486: 3482: 3481: 3479: 3478: 3477: 3476: 3475: 3474: 3469: 3464: 3459: 3454: 3449: 3441: 3440: 3439: 3434: 3429: 3423:Skin diseases 3421: 3420: 3419: 3414: 3409: 3404: 3396: 3395: 3394: 3389: 3381: 3380: 3379: 3374: 3366: 3365: 3364: 3359: 3354: 3349: 3339: 3334: 3329: 3321: 3316: 3311: 3310: 3309: 3304: 3299: 3291: 3285: 3283: 3277: 3276: 3274: 3273: 3268: 3263: 3258: 3253: 3248: 3242: 3240: 3234: 3233: 3231: 3230: 3225: 3220: 3215: 3213:Amniotic fluid 3209: 3207: 3200: 3196: 3195: 3192: 3191: 3189: 3188: 3183: 3178: 3173: 3168: 3163: 3161:Multiple birth 3158: 3153: 3148: 3143: 3138: 3133: 3132: 3131: 3126: 3121: 3111: 3106: 3101: 3096: 3095: 3094: 3089: 3084: 3069: 3067: 3063: 3062: 3060: 3059: 3054: 3049: 3044: 3043: 3042: 3032: 3027: 3022: 3017: 3012: 3011: 3010: 3000: 2994: 2992: 2988: 2987: 2985: 2984: 2979: 2974: 2969: 2967:Bradley method 2963: 2961: 2954: 2948: 2947: 2945: 2944: 2939: 2934: 2929: 2924: 2919: 2914: 2909: 2904: 2899: 2894: 2888: 2886: 2882: 2881: 2879: 2878: 2873: 2868: 2867: 2866: 2859:Pregnancy test 2856: 2851: 2845: 2843: 2839: 2838: 2836: 2835: 2830: 2825: 2824: 2823: 2818: 2813: 2808: 2803: 2792: 2790: 2784: 2783: 2781: 2780: 2775: 2770: 2765: 2759: 2757: 2751: 2750: 2739: 2738: 2731: 2724: 2716: 2710: 2709: 2703: 2686: 2680: 2667: 2661: 2648: 2642: 2627: 2621: 2604: 2601: 2598: 2597: 2550: 2507:(3): 256–264. 2484: 2411: 2348: 2319:(4): 412–417. 2299: 2287: 2249: 2206:(3): 397–402. 2186: 2131: 2066: 2016: 1953: 1889: 1832: 1761: 1742: 1712: 1702: 1642: 1593: 1574: 1508: 1471:(2): 284–289. 1451: 1404: 1345: 1318:(3): 201–208. 1298: 1271:(3): 201–208. 1251: 1204: 1178: 1164: 1115: 1071: 1042:(5): 589–604. 1022: 1004: 969: 950:(3): 151–161. 934: 917: 895: 839: 804: 775:(6): 878–885. 754: 753: 751: 748: 747: 746: 739: 736: 735: 734: 731: 728: 684:soluble or by 657: 654: 594: 591: 590: 589: 586: 577:; washing all 571: 567: 556: 544: 541: 540: 539: 532:hypothyroidism 530:in women with 524: 518: 515:Carbon dioxide 512: 507: 504: 469: 466: 425: 422: 399:sulfur dioxide 388: 385: 372: 369: 363: 360: 347: 344: 321:methyl mercury 303: 300: 287:Main article: 284: 281: 268: 265: 259: 256: 241:Many cases of 228: 225: 224: 223: 220: 217: 214: 211: 204: 203: 197: 188: 183: 153:carcinogenesis 141:can be termed 124: 121: 115: 112: 100: 97: 9: 6: 4: 3: 2: 3711: 3700: 3697: 3695: 3692: 3690: 3687: 3685: 3682: 3680: 3677: 3676: 3674: 3659: 3656: 3655: 3653: 3649: 3639: 3636: 3634: 3631: 3629: 3626: 3624: 3621: 3620: 3618: 3614: 3608: 3605: 3603: 3602:Monthly nurse 3600: 3598: 3595: 3593: 3590: 3588: 3585: 3584: 3582: 3578: 3572: 3569: 3567: 3564: 3562: 3559: 3557: 3554: 3552: 3549: 3547: 3544: 3542: 3539: 3538: 3536: 3532: 3529: 3527: 3523: 3513: 3510: 3508: 3505: 3503: 3500: 3498: 3495: 3493: 3492:Amniocentesis 3490: 3489: 3487: 3483: 3473: 3470: 3468: 3465: 3463: 3460: 3458: 3455: 3453: 3452:Vaginal flora 3450: 3448: 3445: 3444: 3442: 3438: 3435: 3433: 3430: 3428: 3425: 3424: 3422: 3418: 3415: 3413: 3410: 3408: 3405: 3403: 3400: 3399: 3397: 3393: 3390: 3388: 3385: 3384: 3382: 3378: 3375: 3373: 3370: 3369: 3367: 3363: 3360: 3358: 3355: 3353: 3350: 3348: 3345: 3344: 3343: 3342:Substance use 3340: 3338: 3335: 3333: 3330: 3328: 3325: 3324: 3322: 3320: 3317: 3315: 3312: 3308: 3305: 3303: 3300: 3298: 3295: 3294: 3292: 3290: 3287: 3286: 3284: 3282: 3278: 3272: 3269: 3267: 3264: 3262: 3259: 3257: 3256:Fundal height 3254: 3252: 3249: 3247: 3244: 3243: 3241: 3239: 3235: 3229: 3226: 3224: 3221: 3219: 3216: 3214: 3211: 3210: 3208: 3204: 3201: 3197: 3187: 3184: 3182: 3179: 3177: 3174: 3172: 3169: 3167: 3164: 3162: 3159: 3157: 3154: 3152: 3149: 3147: 3144: 3142: 3139: 3137: 3134: 3130: 3127: 3125: 3122: 3120: 3117: 3116: 3115: 3112: 3110: 3107: 3105: 3102: 3100: 3097: 3093: 3090: 3088: 3085: 3083: 3080: 3079: 3078: 3074: 3071: 3070: 3068: 3064: 3058: 3055: 3053: 3050: 3048: 3045: 3041: 3038: 3037: 3036: 3033: 3031: 3028: 3026: 3023: 3021: 3018: 3016: 3013: 3009: 3008:Preterm birth 3006: 3005: 3004: 3001: 2999: 2996: 2995: 2993: 2989: 2983: 2980: 2978: 2975: 2973: 2972:Hypnobirthing 2970: 2968: 2965: 2964: 2962: 2958: 2955: 2953: 2949: 2943: 2940: 2938: 2935: 2933: 2930: 2928: 2925: 2923: 2920: 2918: 2915: 2913: 2910: 2908: 2905: 2903: 2900: 2898: 2895: 2893: 2890: 2889: 2887: 2883: 2877: 2874: 2872: 2869: 2865: 2862: 2861: 2860: 2857: 2855: 2852: 2850: 2849:3D ultrasound 2847: 2846: 2844: 2840: 2834: 2831: 2829: 2826: 2822: 2819: 2817: 2814: 2812: 2809: 2807: 2804: 2802: 2799: 2798: 2797: 2794: 2793: 2791: 2789: 2785: 2779: 2776: 2774: 2771: 2769: 2766: 2764: 2763:Birth control 2761: 2760: 2758: 2756: 2752: 2748: 2744: 2737: 2732: 2730: 2725: 2723: 2718: 2717: 2714: 2706: 2704:1-903985-14-5 2700: 2695: 2694: 2687: 2683: 2681:0-8247-0265-4 2677: 2673: 2668: 2664: 2662:0-8451-0241-9 2658: 2654: 2649: 2645: 2643:0-7817-0137-6 2639: 2635: 2634: 2628: 2624: 2618: 2614: 2613: 2607: 2606: 2593: 2589: 2585: 2581: 2577: 2573: 2569: 2565: 2561: 2554: 2540:on 2017-05-06 2536: 2532: 2528: 2523: 2518: 2514: 2510: 2506: 2502: 2495: 2488: 2480: 2474: 2466: 2462: 2457: 2452: 2447: 2442: 2438: 2434: 2430: 2426: 2422: 2415: 2407: 2401: 2393: 2389: 2384: 2379: 2375: 2371: 2368:(2): 163–72. 2367: 2363: 2359: 2352: 2344: 2340: 2335: 2330: 2326: 2322: 2318: 2314: 2310: 2303: 2296: 2291: 2284: 2280: 2273: 2268: 2264: 2260: 2253: 2245: 2239: 2231: 2227: 2222: 2217: 2213: 2209: 2205: 2201: 2197: 2190: 2182: 2176: 2168: 2164: 2159: 2154: 2151:(4): 307–18. 2150: 2146: 2142: 2135: 2127: 2123: 2118: 2113: 2109: 2105: 2101: 2097: 2093: 2089: 2085: 2081: 2077: 2070: 2062: 2056: 2048: 2044: 2040: 2036: 2033:(2): 104–21. 2032: 2028: 2020: 2012: 2006: 1998: 1994: 1989: 1984: 1980: 1976: 1972: 1968: 1964: 1957: 1949: 1945: 1940: 1935: 1931: 1927: 1923: 1919: 1915: 1911: 1907: 1900: 1898: 1896: 1894: 1885: 1881: 1876: 1871: 1867: 1863: 1859: 1855: 1851: 1847: 1843: 1836: 1828: 1822: 1814: 1810: 1805: 1800: 1796: 1792: 1788: 1784: 1781:(6): 475–80. 1780: 1776: 1772: 1765: 1757: 1753: 1746: 1738: 1734: 1730: 1726: 1722: 1718: 1706: 1698: 1694: 1689: 1684: 1680: 1676: 1672: 1668: 1664: 1660: 1656: 1649: 1647: 1638: 1634: 1629: 1624: 1620: 1616: 1612: 1608: 1604: 1597: 1590: 1586: 1583: 1578: 1570: 1566: 1562: 1558: 1553: 1552:11250/2735605 1548: 1544: 1540: 1536: 1532: 1528: 1524: 1520: 1512: 1504: 1500: 1495: 1490: 1486: 1482: 1478: 1474: 1470: 1466: 1462: 1455: 1447: 1443: 1439: 1435: 1431: 1427: 1423: 1419: 1415: 1408: 1400: 1396: 1391: 1386: 1382: 1378: 1373: 1368: 1364: 1360: 1356: 1349: 1341: 1337: 1333: 1329: 1325: 1321: 1317: 1313: 1309: 1302: 1294: 1290: 1286: 1282: 1278: 1274: 1270: 1266: 1262: 1255: 1247: 1243: 1239: 1235: 1231: 1227: 1223: 1219: 1215: 1208: 1192: 1188: 1182: 1175: 1168: 1160: 1156: 1152: 1148: 1143: 1138: 1134: 1130: 1129:AAOHN Journal 1126: 1119: 1111: 1107: 1102: 1097: 1093: 1089: 1085: 1078: 1076: 1067: 1063: 1058: 1053: 1049: 1045: 1041: 1037: 1033: 1026: 1018: 1014: 1008: 1000: 996: 992: 986: 984: 982: 980: 978: 976: 974: 965: 961: 957: 953: 949: 945: 938: 931: 930:9788131225561 927: 921: 905: 899: 891: 887: 882: 877: 872: 867: 863: 859: 858:PLOS Medicine 855: 848: 846: 844: 835: 831: 827: 823: 819: 815: 808: 800: 796: 791: 786: 782: 778: 774: 770: 766: 759: 755: 745: 742: 741: 732: 729: 726: 722: 721: 720: 718: 714: 709: 707: 703: 699: 695: 691: 687: 683: 679: 675: 671: 667: 663: 653: 650: 646: 643: 639: 638:air pollution 635: 631: 627: 623: 620: 616: 615:preterm birth 610: 608: 604: 600: 587: 584: 580: 576: 572: 568: 565: 564:bottled water 561: 557: 554: 553: 552: 550: 538:in the child. 537: 533: 529: 525: 522: 519: 516: 513: 510: 509: 503: 501: 497: 493: 489: 488:census tracts 485: 480: 478: 474: 465: 461: 458: 453: 450: 445: 443: 439: 435: 430: 421: 419: 415: 411: 409: 403: 400: 395: 393: 392:Air pollution 387:Air pollution 384: 382: 377: 368: 359: 355: 353: 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Index

Environmental toxins in pregnancy
toxic substances
fetus
prenatal development
embryo
pregnancy complications
polychlorinated biphenyls
organochlorine pesticides
perfluorinated compounds
phenols
polybrominated diphenyl ethers
phthalates
polycyclic aromatic hydrocarbons
perchlorate
environmental estrogens
Bisphenol A
Brain health and pollution
Teratology
Congenital abnormality
congenital abnormalities
teratogen
malformation
carcinogenesis
mutagenesis
deficient growth
pregnancy wastage
Drugs in pregnancy
recreational drug use
pharmaceutical drugs
Vertically transmitted infections

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